CN105395714A - Lung diffusing and asthma relieving preparation for treating pneumoconiosis and preparing method thereof - Google Patents

Lung diffusing and asthma relieving preparation for treating pneumoconiosis and preparing method thereof Download PDF

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CN105395714A
CN105395714A CN201510830239.6A CN201510830239A CN105395714A CN 105395714 A CN105395714 A CN 105395714A CN 201510830239 A CN201510830239 A CN 201510830239A CN 105395714 A CN105395714 A CN 105395714A
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Abstract

The invention discloses a lung diffusing and asthma relieving preparation for treating pneumoconiosis. The preparation is mainly prepared from, by mass, 7-12 parts of vitex leaves, 9-13 parts of rust-brown crotalaria, 6-10 parts of aizoon stonecrop herb, 4-9 parts of horsetail, 6-12 parts of scammoniae radix, 5-10 parts of ardisia crispa, 8-13 parts of calceolaria crenatiflora, 5-9 parts of rhizoma corydalis, 7-11 parts of dragon tongue leaves, 4-8 parts of rhizoma atractylodis, 9-14 parts of Japan clover herb, 5-8 parts of exocarpium citri rubrum, 8-15 parts of longan aril and 7-13 parts of aleuritopteris. The preparation is obtained based on years of clinical practice, can tonify spleen to remove dampness and moisten lung to clear heat, and has a remarkable treatment effect.

Description

A kind of lung qi dispersing Dingchuan ' and method for making curing mainly pneumoconiosis
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of the lung qi dispersing Dingchuan ' and the method for making that cure mainly pneumoconiosis.
Background technology
In vocational activity, particularly production process, because sucking harmful dust for a long time, causing the disease turning to major lesions with the extensive fiber of lung, being referred to as pneumoconiosis.Pneumoconiosis is without special clinical manifestation, and its clinical manifestation is how relevant with complication.How not obvious the cough of early stage pneumoconiosis patients is, but along with the exhibition of spouting of the course of disease, patient's many merging chronic bronchitis, end-stage patients' many merging pulmonary infection, all can make cough obviously increase the weight of.Cough relevant with season, weather etc.Expectoration mainly respiratory system to caused by the continuous removing of dust.General expectoration amount is few, mostly is the thin expectorant of Lycoperdon polymorphum Vitt.As merged intrapulmonary infection and chronic bronchitis, amount of expectoration is showed increased then, and expectorant is yellow, viscous or bulk.Chang Buyi expectoration.Pneumoconiosis patients usually feels chest pain, and chest pain is many without relevant or parallel relation with pneumoconiosis clinical manifestation.Differing in position, and often changes, and mostly is limitation.Be generally dull pain, also can distending pain, prickling-like pain etc.With increasing the weight of of lung fibrosis degree, effective Respiratory area reduces, and ventilation/blood flow is out of proportion, and dyspnea also increases the weight of gradually.The generation of complication can obviously increase the weight of dyspneic degree and development speed.Except above-mentioned Respiratory symptoms, can have the General Symptoms that degree is different, common have digestive function to subtract.
Publication No. CN104491097A(application number 201510021867.X) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of pneumoconiosis, be made up of the raw material of following weight portion: Semen Raphani 6-15 part, Folium Pyrrosiae 3-8 part, Radix Paeoniae Alba 10-15 part, Semen Cassiae 5-10 part, Folium Eriobotryae 8-13 part, Cortex Cinnamomi 10-20 part, Pumex 9-11 part, Periostracum Cicadae 1-5 part, Fructus Aurantii 5-10 part, Radix Trichosanthis 8-15 part, Spica Prunellae 10-20 part.Publication No. CN104189457A(application number 201410477626.1) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of pneumoconiosis, adopt Bulbus Fritillariae Cirrhosae, Fructus Trichosanthis, Thallus Laminariae (Thallus Eckloniae), Radix Ophiopogonis, Radix Asparagi, Cortex Lycii, Bulbus Lilii, Radix Scrophulariae, Herba Albiziae, Radix Saposhnikoviae, Radix Platycodonis, Exocarpium Citri Rubrum, Herba Tripterospermi, Herba Ephedrae, Gecko, Semen Armeniacae Amarum, Sargassum composition.Publication No. CN104958351A(application number 201510368605.0) Chinese patent literature disclose a kind of pharmaceutical composition for the treatment of pneumoconiosis, the each component of this medicine is according to parts by weight, and its proportioning is: Radix Platycodonis 10-20 part, Teroo hydrochloride 1-3 part, Radix Astragali 5-10 part, Radix Glycyrrhizae 3-9 part, Radix Bupleuri 10-20 part.
The medicine being used for the treatment of pneumoconiosis is at present main mainly with improving symptom, and treatment time is longer, and effect improved very not remarkable, larger burden is caused for patient, by studying a kind of Chinese medicine formula, thus reach and both can strengthen patient's body constitution, effectively can alleviate again the effect of the uncomfortable disease of silicosis.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of curative effect reliable, take the safe lung qi dispersing Dingchuan ' curing mainly pneumoconiosis and method for making.
Technical scheme of the present invention is:
Cure mainly a lung qi dispersing Dingchuan ' for pneumoconiosis, be prepared from primarily of following bulk drugs, be mass parts: Folium Viticis Negundo 7-12; Herba Crotalariae Ferrugineae 9-13; Herba Sedi Aizoon 6-10; Herba Equiseti Hiemalis 4-9; Radix Calystegiae sepii 6-12; Radix Ardisiae Crispae 5-10; Flos clerodendri japonici 8-13; Rhizoma Corydalis 5-9; Flos Sauropi changiani leaf 7-11; Rhizoma Atractylodis 4-8; Herba Kummerowiae Striatae 9-14; Exocarpium Citri Rubrum 5-8; Arillus Longan 8-15; Aleuritopteris farinsa (Forsk.) Fee 7-13.
Preferred version is, Folium Viticis Negundo 9-10; Herba Crotalariae Ferrugineae 10-12; Herba Sedi Aizoon 7-9; Herba Equiseti Hiemalis 5-8; Radix Calystegiae sepii 8-10; Radix Ardisiae Crispae 6-9; Flos clerodendri japonici 9-12; Rhizoma Corydalis 6-8; Flos Sauropi changiani leaf 8-10; Rhizoma Atractylodis 5-7; Herba Kummerowiae Striatae 10-13; Exocarpium Citri Rubrum 6-7; Arillus Longan 10-13; Aleuritopteris farinsa (Forsk.) Fee 9-11.
More preferably, Folium Viticis Negundo 9.5; Herba Crotalariae Ferrugineae 11; Herba Sedi Aizoon 8; Herba Equiseti Hiemalis 6.5; Radix Calystegiae sepii 9; Radix Ardisiae Crispae 7.5; Flos clerodendri japonici 10.5; Rhizoma Corydalis 7; Flos Sauropi changiani leaf 9; Rhizoma Atractylodis 6; Herba Kummerowiae Striatae 11.5; Exocarpium Citri Rubrum 6.5; Arillus Longan 11.5; Aleuritopteris farinsa (Forsk.) Fee 10.
The preparation method of the decoction of described preparation, step is as follows:
(1) by Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf removing impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, add crude drug quality 0.3-0.5 rice vinegar doubly (preferred: the rice vinegar adding 0.4 times of crude drug quality), little fire heating is changed after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, after filtration, obtain Jiang Shui, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, be placed in Jiang Shuizhong and soak 8-18 minute (preferably: soak 10-16 minute; Be more preferably: soak 13 minutes), take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 10-18 minute (preferably: water proof heating 12-16 minute; Be more preferably: water proof heats 14 minutes), take out slow fire fried dry, cool;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, it is (preferred: Steam by water bath 20-24 minute to add washing water of rice Steam by water bath 16-28 minute; Be more preferably: Steam by water bath 22 minutes), take out and dry, pulverize together with step (1) (2) (3) made crude drug, make medicated powder;
(5) step (4) gained medicated powder is loaded in bag filter, adds the alcoholic solution reflux, extract, twice that concentration is 80%, each persistent period be 1-2 hour (preferred: each persistent period is 1.2-1.8 hour; Be more preferably: each persistent period is 1.5 hours), collecting by filtration filtrate, and be recycled to without alcohol taste, obtain decoction.
The preparation method of described preparation decoction, the amount that step (5) adds alcoholic solution is that the 8-10 of medicated powder quality is doubly (preferred: the amount adding alcoholic solution is 8.5-9.5 times of medicated powder quality; Be more preferably: the amount adding alcoholic solution is 9 times of medicated powder quality).
The preparation method of the soft extract of described preparation, step is as follows:
(1) by Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf removing impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, add crude drug quality 0.3-0.5 rice vinegar doubly (preferred: the rice vinegar adding 0.4 times of crude drug quality), little fire heating is changed after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, after filtration, obtain Jiang Shui, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, be placed in Jiang Shuizhong and soak 8-18 minute (preferably: soak 10-16 minute; Be more preferably: soak 13 minutes), take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 10-18 minute (preferably: water proof heating 12-16 minute; Be more preferably: water proof heats 14 minutes), take out slow fire fried dry, cool;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, it is (preferred: Steam by water bath 20-24 minute to add washing water of rice Steam by water bath 16-28 minute; Be more preferably: Steam by water bath 22 minutes), take out and dry, pulverize together with step (1) (2) (3) made crude drug, make medicated powder;
(5) loaded in bag filter by step (4) gained medicated powder, the concentration adding medicated powder quality 8 times is the alcoholic solution of 80%, reflux, extract, twice, each persistent period be 1-2 hour (preferred: each persistent period is 1.2-1.8 hour; Be more preferably: each persistent period is 1.5 hours), collecting by filtration filtrate, and be recycled to without alcohol taste, continue heating and be concentrated into clear paste, add refined honey mix homogeneously, obtain soft extract.
The preparation method of described preparation soft extract, it is that the 0.2-0.4 of clear paste quality is doubly (preferred: to add 0.25-0.35 times that refined honey amount is thick paste quality that step (5) adds refined honey amount; Be more preferably: add 0.3 times that refined honey amount is clear paste quality).
The preparation method of the granule of described preparation, step is as follows:
(1) by Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf removing impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, add crude drug quality 0.3-0.5 rice vinegar doubly (preferred: the rice vinegar adding 0.4 times of crude drug quality), little fire heating is changed after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, after filtration, obtain Jiang Shui, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, be placed in Jiang Shuizhong and soak 8-18 minute (preferably: soak 10-16 minute; Be more preferably: soak 13 minutes), take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 10-18 minute (preferably: water proof heating 12-16 minute; Be more preferably: water proof heats 14 minutes), take out slow fire fried dry, cool;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, it is (preferred: Steam by water bath 20-24 minute to add washing water of rice Steam by water bath 16-28 minute; Be more preferably: Steam by water bath 22 minutes), take out and dry, pulverize together with step (1) (2) (3) made crude drug, make medicated powder;
(5) loaded in bag filter by step (4) gained medicated powder, the concentration adding medicated powder quality 8 times is the alcoholic solution of 80%, reflux, extract, twice, each persistent period be 1-2 hour (preferred: each persistent period is 1.2-1.8 hour; Be more preferably: each persistent period is 1.5 hours), collecting by filtration filtrate, and be recycled to without alcohol taste, heating is concentrated into the thick paste (78 DEG C) that relative density is 1.32, then adds adjuvant sucrose and dextrin, makes soft material, screen drying of sieving, granulate is packed, and obtains granule.
The preparation method of described preparation granules agent, it is (preferred: to screen 70-90 mesh sieve that step (5) screened 60-100 mesh sieve; Be more preferably: screened 80 mesh sieves).
The preparation method of the tablet of described preparation, step is as follows:
(1) by Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf removing impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, add crude drug quality 0.3-0.5 rice vinegar doubly (preferred: the rice vinegar adding 0.4 times of crude drug quality), little fire heating is changed after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, after filtration, obtain Jiang Shui, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, be placed in Jiang Shuizhong and soak 8-18 minute (preferably: soak 10-16 minute; Be more preferably: soak 13 minutes), take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 10-18 minute (preferably: water proof heating 12-16 minute; Be more preferably: water proof heats 14 minutes), take out slow fire fried dry, cool;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, it is (preferred: Steam by water bath 20-24 minute to add washing water of rice Steam by water bath 16-28 minute; Be more preferably: Steam by water bath 22 minutes), take out and dry, pulverize and sieve together with step (1) (2) (3) made crude drug, make medicated powder;
(5) step (4) gained medicated powder is added adjuvant, mix homogeneously, be crushed to oval tablet dosage form, obtain tablet.
The preparation method of described formulation tablet, it is (preferred: to pulverize 100-120 mesh sieve that step (4) pulverized 80-140 mesh sieve; Be more preferably: pulverized 110 mesh sieves).
A kind of lung qi dispersing Dingchuan ' not only scientific formula curing mainly pneumoconiosis provided by the invention, and preparation method is simple, product taking convenience.In addition, excellent results of the present invention also shows:
1, products obtained therefrom therapeutic effect of the present invention is good, anti-recurrence, takes safety and has no side effect;
2, this prescription meets Chinese medicine principle completely, has the effect such as invigorating spleen to remove dampness, moistening lung and clearing heat;
3, the present invention's crude drug source used is extensive, and cost is low, can long-term taking, does not increase financial burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Folium Viticis Negundo: base is former: be the leaf of Verbenaceae Herba Viticis Cannabifoliae.Nature and flavor: acrid in the mouth; Bitter; Property is put down.Function cures mainly: removing dampness of inducing sweat, eliminating phlegm and relieving asthma; Removing toxic substances.Main Common Cold, cough, asthma; Stomachache; Stomachache; Heat-damp in summer dysentery; Beriberi swelling; Rubella pruritus; Tinea pedis; Acute mastitis swells and ache; Snake bite and insect sting.
Herba Crotalariae Ferrugineae: base is former: for the false ground of pulse family Crotalaria plant is blue or the root of bar leaf Herba crotalariae mucronatae or herb.The property of medicine: bitter, micro-acid, flat.Return lung, liver, kidney channel.Function cures mainly: nourishing the liver and kidney, and cough-relieving is breathed heavily, and dampness removing cures mainly tinnitus, deaf, the vertigo, seminal emission, menorrhagia, leucorrhea, chronic cough expectorant blood, asthma, nephritis, dysuria, tonsillitis, parotitis, furuncle swelling toxin.
Herba Sedi Aizoon: base is former: be root or the herb of crassulaceae plants Herba sedi kamtschatici, horizontal root Herba sedi kamtschatici.Nature and flavor: flat; Sweet; Micro-acid.Gui Jing: the heart; Liver; Spleen channel.Function cures mainly: dissipating blood stasis; Hemostasis; Mind tranquilizing and the heart calming; Removing toxic substances.Main haematemesis; Epistaxis; Have blood in stool; Hematuria; Metrorrhagia; Purpura; Traumatic hemorrhage; Traumatic injury; Cardiopalmus; Insomnia; Furuncle carbuncle; Burn and scald; Insect bite.
Herba Equiseti Hiemalis: base is former: be the herb of Equisetaceae plant Herba Equiseti Hiemalis.Nature and flavor: sweetness and bitterness are flat.Gui Jing: enter lung, liver, gallbladder meridian.Function cures mainly: wind-dispelling heat-dissipating, expelling pathogenic factors from muscles, nebula removing.Control the raw nebula of order, epiphora induced by wind, discharging fresh blood stool, dysentery, de-liver, malaria, laryngalgia, carbuncle.
Radix Calystegiae sepii: base is former: be the root of dicotyledon scammonia section plant bellbine.Nature and flavor: sweet; Micro-hardship; Temperature.Gui Jing: lung; Liver; Kidney channel.Function cures mainly: QI invigorating tonify deficiency; Reunion of fractured tendons and bones; Removing toxic substances; Parasite killing.Main erysipelas; Strain; Incised wound; Ascariasis.
Radix Ardisiae Crispae: base is former: be the root and rhizome of Myrsinacea plant Radix Ardisiae Crispae or its mutation great Ye Radix Ardisiae Crispae, thin handle Radix Ardisiae Crispae.Nature and flavor: bitter; Pungent; Cool in nature.Function cures mainly: relieving sore-throat by clearing away heat; Eliminate the phlegm dampness removing; Promoting blood circulation and detoxication.Main laryngopharynx swelling and pain; Cough is coughed up phlegm not smooth, jaundice due to damp-heat; Urine leaching pain; Rheumatic arthralgia; Traumatic injury; Furuncle; Innominate toxic swelling; Venom.
Flos clerodendri japonici: base is former: be the flower of Verenaceae Caulis et folium clerodendri bungei Shu Zhi Wu Cheng paulownia.Nature and flavor: sweet; Flat.Gui Jing: spleen channel.Function cures mainly: calm the nerves; Hemostasis.Main palpitation and insomnia; Bleeding hemorrhoids.
Rhizoma Corydalis: base is former: be the tuber of papaveraceae plant corydalis.Nature and flavor: arduous, temperature.Gui Jing: enter liver, stomach warp.Function cures mainly: invigorate blood circulation, and dissipating blood stasis is regulated the flow of vital energy, pain relieving.Control all pains of trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.
Flos Sauropi changiani leaf: base is former: be the leaf of euphorbia plant Flos Sauropi changiani leaf.Nature and flavor: sweet; Flat.Gui Jing: lung meridian.Function cures mainly: clearing heat and moistening lung; Preventing phlegm from forming and stopping coughing.Main lung-heat cough with asthma abundant expectoration; Xerostomia; Constipation.
Rhizoma Atractylodis: base is former: be the rhizome of feverfew RHIZOMA ATRACTYLODIS IANCEAE or Atractylis chinensis etc.Nature and flavor: arduous, temperature.Gui Jing: enter spleen, stomach warp.Function cures mainly: spleen invigorating, dampness, resolving depression, wards off dirty.Control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, and seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.
Herba Kummerowiae Striatae: base is former: be the herb of leguminous plant Herba Kummerowiae Striatae.Chemical analysis: clavus blade of grass is containing flavonoid, glycoside.Nature and flavor: sweet, pungent are flat.Function cures mainly: heat-clearing and toxic substances removing, invigorating spleen to remove dampness.Cure cold heating, and heat-damp in summer is vomited and diarrhoea, malaria, dysentery, infectious hepatitis, pyretic stranguria, nebulousurine.
Exocarpium Citri Rubrum: base is former: be the outside rind of rutaceae orange and variety thereof.Nature and flavor: pungent; Bitter; Temperature.Gui Jing: return lung, spleen channel.Function cures mainly: cold expelling dampness; Activating QI to eliminate phlegm; Alleviating distention in middle-JIAO stomach invigorating.Main cough due to wind and cold; Abundant expectoration QI rising in reverse order; Nausea and vomiting; Breast gastral cavity painful abdominal mass is swollen.
Arillus Longan: base is former: be the aril of sapindaceous plant Arillus Longan.Nature and flavor: sweet; Temperature.Gui Jing: the heart; Kidney; Liver; Spleen channel.Function cures mainly: reinforcing the heart spleen; Replenishing QI and blood; Tranquilizing mind.Main deficiency of both the heart and spleen; Palpitation with fear caused by insufficiency of vital energy and blood; Palpitation with a distress feeling; Insomnia; Forgetful; Blood deficiency and yellow complexion; Have through uncomfortable; Metrorrhagia.
Aleuritopteris farinsa (Forsk.) Fee: base is former: be the herb of Sinopteridaceae plant Aleuritopteris farinsa (Forsk.) Fee.Nature and flavor: temperature; Light; Flat micro-puckery; Nontoxic.Gui Jing: lung; Spleen; Liver Channel.Function cures mainly: expelling phlegm for arresting cough; Invigorating spleen to remove dampness; Promoting blood circulation and hemostasis.Main cough; Have loose bowels; Dysentery; Dyspepsia; Menoxenia; Spit blood; Have blood in stool; Leucorrhea; Stranguria; Traumatic injury; Scrofula.
embodiment 1cure mainly a lung qi dispersing Dingchuan ' for pneumoconiosis, be prepared from (every part of 10g) primarily of following bulk drugs: Folium Viticis Negundo 7 parts, Herba Crotalariae Ferrugineae 9 parts, Herba Sedi Aizoon 6 parts, Herba Equiseti Hiemalis 4 parts, Radix Calystegiae sepii 6 parts, Radix Ardisiae Crispae 5 parts, Flos clerodendri japonici 8 parts, Rhizoma Corydalis 5 parts, Flos Sauropi changiani leaf 7 parts, Rhizoma Atractylodis 4 parts, Herba Kummerowiae Striatae 9 parts, Exocarpium Citri Rubrum 5 parts, Arillus Longan 8 parts, Aleuritopteris farinsa (Forsk.) Fee 7 parts.Above-mentioned a kind of preparation method curing mainly the lung qi dispersing Dingchuan ' decoction of pneumoconiosis is:
(1) Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf are removed impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, adds the rice vinegar of crude drug quality 0.4 times, and change little fire heating after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, obtain Jiang Shui after filtration, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, and be placed in Jiang Shuizhong and soak 13 minutes, take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 14 minutes, takes out slow fire fried dry, cools;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, add washing water of rice Steam by water bath 22 minutes, take out and dry, pulverize together with step (1) (2) (3) made crude drug, make medicated powder;
(5) loaded in bag filter by step (4) gained medicated powder, the concentration adding medicated powder quality 9 times is the alcoholic solution of 80%, reflux, extract, twice, and each persistent period is 1.5 hours, collecting by filtration filtrate, and is recycled to without alcohol taste, obtains decoction.
embodiment 2cure mainly a lung qi dispersing Dingchuan ' for pneumoconiosis, be prepared from (every part of 10g) primarily of following bulk drugs: Folium Viticis Negundo 12 parts, Herba Crotalariae Ferrugineae 13 parts, Herba Sedi Aizoon 10 parts, Herba Equiseti Hiemalis 9 parts, Radix Calystegiae sepii 12 parts, Radix Ardisiae Crispae 10 parts, Flos clerodendri japonici 13 parts, Rhizoma Corydalis 9 parts, Flos Sauropi changiani leaf 11 parts, Rhizoma Atractylodis 8 parts, Herba Kummerowiae Striatae 14 parts, Exocarpium Citri Rubrum 8 parts, Arillus Longan 15 parts, Aleuritopteris farinsa (Forsk.) Fee 13 parts.A kind of preparation method curing mainly the lung qi dispersing Dingchuan ' soft extract of pneumoconiosis is:
(1) Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf are removed impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, adds the rice vinegar of crude drug quality 0.4 times, and change little fire heating after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, obtain Jiang Shui after filtration, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, and be placed in Jiang Shuizhong and soak 13 minutes, take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 14 minutes, takes out slow fire fried dry, cools;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, add washing water of rice Steam by water bath 22 minutes, take out and dry, pulverize together with step (1) (2) (3) made crude drug, make medicated powder;
(5) step (4) gained medicated powder is loaded in bag filter, the concentration adding medicated powder quality 8 times is the alcoholic solution of 80%, reflux, extract, twice, each persistent period is 1.5 hours, collecting by filtration filtrate, and be recycled to without alcohol taste, continue heating and be concentrated into clear paste, add the refined honey mix homogeneously of clear paste quality 0.3 times, obtain soft extract.
Model case: xxx, female, 42 years old.Main suit: bring up phlegm when one coughs, breathe and have some setbacks; Medical history: patient once in cotton mill's working, affected by dust throughout the year, and passive protective physical fitness declines, breathing has some setbacks, cough and expectoration is serious, and the recent state of an illness increases the weight of gradually, sensation of oppression over the chest with shortness of breath, nighttime sleep Quality Down, to examination in hospital, through x-ray display, there is circular small opacities in pulmonary, each diameter, less than 2cm, is finally diagnosed as pneumoconiosis.
Take a kind of lung qi dispersing Dingchuan ' soft extract curing mainly pneumoconiosis of the present embodiment gained, every day 2 times, each 6-10g, warm boiled water, 15 days courses for the treatment of.Patient takes a course for the treatment of, and cough and expectoration symptom alleviates, and conscious health is light, and after adhering to taking three courses for the treatment of, the uncomfortable disease of patient obviously alleviates, can orthobiosis, and check display, shade is eliminated substantially, and after consolidating three days, patient fully recovers.
embodiment 3cure mainly a lung qi dispersing Dingchuan ' for pneumoconiosis, be prepared from (every part of 10g) primarily of following bulk drugs: Folium Viticis Negundo 9 parts, Herba Crotalariae Ferrugineae 10 parts, Herba Sedi Aizoon 7 parts, Herba Equiseti Hiemalis 5 parts, Radix Calystegiae sepii 8 parts, Radix Ardisiae Crispae 6 parts, Flos clerodendri japonici 9 parts, Rhizoma Corydalis 6 parts, Flos Sauropi changiani leaf 8 parts, Rhizoma Atractylodis 5 parts, Herba Kummerowiae Striatae 10 parts, Exocarpium Citri Rubrum 6 parts, Arillus Longan 10 parts, Aleuritopteris farinsa (Forsk.) Fee 9 parts.A kind of preparation method curing mainly the lung qi dispersing Dingchuan ' granule of pneumoconiosis is:
(1) Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf are removed impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, adds the rice vinegar of crude drug quality 0.4 times, and change little fire heating after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, obtain Jiang Shui after filtration, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, and be placed in Jiang Shuizhong and soak 13 minutes, take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 14 minutes, takes out slow fire fried dry, cools;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, add washing water of rice Steam by water bath 22 minutes, take out and dry, pulverize together with step (1) (2) (3) made crude drug, make medicated powder;
(5) step (4) gained medicated powder is loaded in bag filter, the concentration adding medicated powder quality 8 times is the alcoholic solution of 80%, reflux, extract, twice, and each persistent period is 1.5 hours, collecting by filtration filtrate, and being recycled to without alcohol taste, heating is concentrated into the thick paste (78 DEG C) that relative density is 1.32, then adds adjuvant sucrose and dextrin, make soft material, screened 80 mesh sieves dry, granulate is packed, and obtains granule.
Model case: xxx, man, 38 years old.Medical history: patient works 3 years in colliery factory, in the recent period prominent sense chest dull pain, cough is serious, and throat is itched, every morning WA, have yellow sticky expectorant, before two weeks, start to occur dyspnea, chest distress and palpitation symptoms, health is weak, dry weight cannot live, then arrive examination in hospital, through x-ray display, be diagnosed as pneumoconiosis.Take many western medicines, remission is not obvious.
Recommend to take a kind of lung qi dispersing Dingchuan ' granule curing mainly pneumoconiosis of the present embodiment gained through people, adopt every day 2 times, each 3-4g, with warm boiled water, 15 days courses for the treatment of.After patient takes two courses for the treatment of, alleviation uncomfortable in chest, cough alleviates, and uncomfortable disease obviously alleviates, after continuing to take two courses for the treatment of, the body constitution of patient is strengthened, and normally can work, have rosy cheeks, energy increases comparatively before, and patient's self-induction is fully recovered, and follow up a case by regular visits in 1 year, the state of an illness does not recur.
embodiment 4cure mainly a lung qi dispersing Dingchuan ' for pneumoconiosis, be prepared from (every part of 10g) primarily of following bulk drugs: Folium Viticis Negundo 10 parts, Herba Crotalariae Ferrugineae 12 parts, Herba Sedi Aizoon 9 parts, Herba Equiseti Hiemalis 8 parts, Radix Calystegiae sepii 10 parts, Radix Ardisiae Crispae 9 parts, Flos clerodendri japonici 12 parts, Rhizoma Corydalis 8 parts, Flos Sauropi changiani leaf 10 parts, Rhizoma Atractylodis 7 parts, Herba Kummerowiae Striatae 13 parts, Exocarpium Citri Rubrum 7 parts, Arillus Longan 13 parts, Aleuritopteris farinsa (Forsk.) Fee 11 parts.A kind of preparation method curing mainly the lung qi dispersing Dingchuan ' tablet of pneumoconiosis is:
(1) Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf are removed impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, adds the rice vinegar of crude drug quality 0.4 times, and change little fire heating after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, obtain Jiang Shui after filtration, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, and be placed in Jiang Shuizhong and soak 13 minutes, take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 14 minutes, takes out slow fire fried dry, cools;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, add washing water of rice Steam by water bath 22 minutes, take out and dry, pulverized 110 mesh sieves together with step (1) (2) (3) made crude drug, make medicated powder;
(5) step (4) gained medicated powder is added adjuvant, mix homogeneously, be crushed to oval tablet dosage form, obtain tablet.
Model case: xxx, man, 56 years old.Medical history: check out the pneumoconiosis II phase during patient's health check-up the year before last, just started symptom significantly, be just not placed in the heart, the rear state of an illness increases the weight of gradually, cough does not stop, chest distress and palpitation symptoms, slightly tired, just dyspnea, asthma is serious, by taking western medicine, effect improved not obvious, then finds tcm methods treatment.
Take a kind of lung qi dispersing Dingchuan ' tablet curing mainly pneumoconiosis of the present embodiment gained, adopt every day 2 times, each 2-3 sheet, with warm boiled water, 15 days courses for the treatment of.After patient takes a course for the treatment of, the symptoms such as cough obviously alleviate, and breathe smooth and easy, continue to take two courses for the treatment of, and patient's muscle power strengthens, and has rosy cheeks, and check display pulmonary shadow disappears substantially, and after consolidating a course for the treatment of, patient fully recovers, and all diseases disappear entirely.
embodiment 5cure mainly a lung qi dispersing Dingchuan ' for pneumoconiosis, be prepared from (every part of 10g) primarily of following bulk drugs: Folium Viticis Negundo 9.5 parts, Herba Crotalariae Ferrugineae 11 parts, Herba Sedi Aizoon 8 parts, Herba Equiseti Hiemalis 6.5 parts, Radix Calystegiae sepii 9 parts, Radix Ardisiae Crispae 7.5 parts, Flos clerodendri japonici 10.5 parts, Rhizoma Corydalis 7 parts, Flos Sauropi changiani leaf 9 parts, Rhizoma Atractylodis 6 parts, Herba Kummerowiae Striatae 11.5 parts, Exocarpium Citri Rubrum 6.5 parts, Arillus Longan 11.5 parts, Aleuritopteris farinsa (Forsk.) Fee 10 parts.A kind of preparation method curing mainly the lung qi dispersing Dingchuan ' decoction of pneumoconiosis is:
(1) Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf are removed impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, adds the rice vinegar of crude drug quality 0.4 times, and change little fire heating after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, obtain Jiang Shui after filtration, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, and be placed in Jiang Shuizhong and soak 13 minutes, take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 14 minutes, takes out slow fire fried dry, cools;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, add washing water of rice Steam by water bath 22 minutes, take out and dry, pulverize together with step (1) (2) (3) made crude drug, make medicated powder;
(5) loaded in bag filter by step (4) gained medicated powder, the concentration adding medicated powder quality 9 times is the alcoholic solution of 80%, reflux, extract, twice, and each persistent period is 1.5 hours, collecting by filtration filtrate, and is recycled to without alcohol taste, obtains decoction.
test example 1a kind of clinical practice curing mainly the lung qi dispersing Dingchuan ' (embodiment 5) of pneumoconiosis of gained of the present invention:
Choose crowd: in April ,-2015 in June, 2014, according to medical case history, screen lymphatic cancer patient 249 example of accepting for medical treatment in four hospitals, age 27-62 year, 43.6 ± 1.4 years old mean age, the course of disease 4 months-5 years, wherein male patient 138 example, female patient 111 example.
Reference GBZ70-2009 are pneumoconiosis diagnostic criteria, check that pneumoconiosis was divided into for three phases, represent with code name " I ", " II ", " III " through x-ray.1. without pneumoconiosis (" 0 ").0: the x line without pneumoconiosis shows; The performance of 0+:X line is diagnosed as " I " person still not.2. first phase (" I ").I: the similar round small opacities having closeness 1 grade, distribution has at least Liang Gefei district respectively to have a place, often locates diameter and is greater than 2cm; Or having the irregular small opacities of closeness 1 grade, its distribution is no less than Liang Gefei district; I ': small opacities showed increased, but have one to be decided to be " II " person still not in closeness and distribution.8. the second phase (" II ").II: the similar round or the irregular small opacities that have closeness 2 grades, distribution is more than 4 Ge Fei districts; II ': have closeness to be the small opacities of 3 grades, distribution is more than 4 Ge Fei districts, or to have large shade still be not " III " person.4. three phases (" III ").III: have large shade to occur, its major diameter >=2cm, wide footpath >=lcm; III ' has single large shade or multiple large shade, and area summation exceedes the area in right upper lung district.
Before test, patient is divided into two groups at random, experimental group 140 example and matched group 109 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group takes products obtained therefrom of the present invention, each 200-250ml, one day twice, warmly takes, and within 15 days, is a course for the treatment of; Matched group uses other conventional medicines (the white lung lavage buccal tablet of drop, reach pulmonaria officianlis, tetrandrine sheet etc.).During medication, Continuous Observation is carried out to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cures: symptom and clinical sign improve completely, and conducting lung X-ray examination inspection is completely normal; (2) effective: symptom and clinical sign significantly improve, conducting lung X-ray examination inspection obviously improves; (3) effective: symptom and clinical sign make moderate progress, and conducting lung X-ray examination inspection take a favorable turn; (4) invalid: symptom and clinical sign are without improvement, and conducting lung X-ray examination checks unchanged.Total effective rate=cure rate+obvious effective rate+effective percentage.
Clinical effectiveness: after the treatment of four courses for the treatment of, the therapeutic outcome of two groups:
Experimental group: cure 85 examples (60.7%), effective 32 examples (22.9%), effective 20 examples (14.3%), invalid 3 examples (2.1%), total effective rate is 97.9%;
Matched group: cure 44 examples (40.4%), effective 28 examples (25.7%), effective 18 examples (16.5%), invalid 19 examples (17.4%), total effective rate is 82.6%.
By more known, matched group obtains the therapeutic effect that therapeutic effect is starkly lower than experimental group, and illustrate that products obtained therefrom of the present invention is evident in efficacy, therapeutic effect is good.Follow up a case by regular visits to after 1 year, matched group has 21 routine patient condition recurrences, and the recurrence example of experimental group is 8 examples, illustrates that products obtained therefrom of the present invention can treating both the principal and secondary aspects of a disease pneumoconiosis, prevents the state of an illness from again showing effect.
The Chinese medicine used in the present invention, Folium Viticis Negundo can eliminating phlegm and relieving asthma, Herba Crotalariae Ferrugineae can liver-nourishing kidney-boosting, Herba Sedi Aizoon can mind tranquilizing and the heart calming, Herba Equiseti Hiemalis can wind-dispelling heat-dissipating, and Radix Calystegiae sepii can QI invigorating tonify deficiency, and Radix Ardisiae Crispae can relieving sore-throat by clearing away heat, Flos clerodendri japonici can be calmed the nerves hemostasis, Rhizoma Corydalis can regulating QI to relieve pain, and Flos Sauropi changiani leaf can clearing heat and moistening lung, and Rhizoma Atractylodis can the spleen strengthening and damp drying, Herba Kummerowiae Striatae can invigorating spleen to remove dampness, Exocarpium Citri Rubrum can cold expelling dampness, and Arillus Longan can reinforcing the heart strengthening the spleen, and Aleuritopteris farinsa (Forsk.) Fee can expelling phlegm for arresting cough, multiple medical material synergism, plays effect of invigorating spleen to remove dampness, moistening lung and clearing heat altogether.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. cure mainly a lung qi dispersing Dingchuan ' for pneumoconiosis, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Folium Viticis Negundo 7-12; Herba Crotalariae Ferrugineae 9-13; Herba Sedi Aizoon 6-10; Herba Equiseti Hiemalis 4-9; Radix Calystegiae sepii 6-12; Radix Ardisiae Crispae 5-10; Flos clerodendri japonici 8-13; Rhizoma Corydalis 5-9; Flos Sauropi changiani leaf 7-11; Rhizoma Atractylodis 4-8; Herba Kummerowiae Striatae 9-14; Exocarpium Citri Rubrum 5-8; Arillus Longan 8-15; Aleuritopteris farinsa (Forsk.) Fee 7-13.
2. a kind of lung qi dispersing Dingchuan ' curing mainly pneumoconiosis as claimed in claim 1, is characterized in that, Folium Viticis Negundo 9-10; Herba Crotalariae Ferrugineae 10-12; Herba Sedi Aizoon 7-9; Herba Equiseti Hiemalis 5-8; Radix Calystegiae sepii 8-10; Radix Ardisiae Crispae 6-9; Flos clerodendri japonici 9-12; Rhizoma Corydalis 6-8; Flos Sauropi changiani leaf 8-10; Rhizoma Atractylodis 5-7; Herba Kummerowiae Striatae 10-13; Exocarpium Citri Rubrum 6-7; Arillus Longan 10-13; Aleuritopteris farinsa (Forsk.) Fee 9-11(is preferably: Folium Viticis Negundo 9.5; Herba Crotalariae Ferrugineae 11; Herba Sedi Aizoon 8; Herba Equiseti Hiemalis 6.5; Radix Calystegiae sepii 9; Radix Ardisiae Crispae 7.5; Flos clerodendri japonici 10.5; Rhizoma Corydalis 7; Flos Sauropi changiani leaf 9; Rhizoma Atractylodis 6; Herba Kummerowiae Striatae 11.5; Exocarpium Citri Rubrum 6.5; Arillus Longan 11.5; Aleuritopteris farinsa (Forsk.) Fee 10).
3. the preparation method of the decoction of the preparation as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) by Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf removing impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, add crude drug quality 0.3-0.5 rice vinegar doubly (preferred: the rice vinegar adding 0.4 times of crude drug quality), little fire heating is changed after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, after filtration, obtain Jiang Shui, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, be placed in Jiang Shuizhong and soak 8-18 minute (preferably: soak 10-16 minute; Be more preferably: soak 13 minutes), take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 10-18 minute (preferably: water proof heating 12-16 minute; Be more preferably: water proof heats 14 minutes), take out slow fire fried dry, cool;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, it is (preferred: Steam by water bath 20-24 minute to add washing water of rice Steam by water bath 16-28 minute; Be more preferably: Steam by water bath 22 minutes), take out and dry, pulverize together with step (1) (2) (3) made crude drug, make medicated powder;
(5) step (4) gained medicated powder is loaded in bag filter, adds the alcoholic solution reflux, extract, twice that concentration is 80%, each persistent period be 1-2 hour (preferred: each persistent period is 1.2-1.8 hour; Be more preferably: each persistent period is 1.5 hours), collecting by filtration filtrate, and be recycled to without alcohol taste, obtain decoction.
4. the preparation method of preparation decoction as claimed in claim 3, is characterized in that, the amount that step (5) adds alcoholic solution is that the 8-10 of medicated powder quality is doubly (preferred: the amount adding alcoholic solution is 8.5-9.5 times of medicated powder quality; Be more preferably: the amount adding alcoholic solution is 9 times of medicated powder quality).
5. the preparation method of the soft extract of the preparation as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) by Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf removing impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, add crude drug quality 0.3-0.5 rice vinegar doubly (preferred: the rice vinegar adding 0.4 times of crude drug quality), little fire heating is changed after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, after filtration, obtain Jiang Shui, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, be placed in Jiang Shuizhong and soak 8-18 minute (preferably: soak 10-16 minute; Be more preferably: soak 13 minutes), take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 10-18 minute (preferably: water proof heating 12-16 minute; Be more preferably: water proof heats 14 minutes), take out slow fire fried dry, cool;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, it is (preferred: Steam by water bath 20-24 minute to add washing water of rice Steam by water bath 16-28 minute; Be more preferably: Steam by water bath 22 minutes), take out and dry, pulverize together with step (1) (2) (3) made crude drug, make medicated powder;
(5) loaded in bag filter by step (4) gained medicated powder, the concentration adding medicated powder quality 8 times is the alcoholic solution of 80%, reflux, extract, twice, each persistent period be 1-2 hour (preferred: each persistent period is 1.2-1.8 hour; Be more preferably: each persistent period is 1.5 hours), collecting by filtration filtrate, and be recycled to without alcohol taste, continue heating and be concentrated into clear paste, add refined honey mix homogeneously, obtain soft extract.
6. the preparation method of preparation soft extract as claimed in claim 5, is characterized in that, it is that the 0.2-0.4 of clear paste quality is doubly (preferred: to add 0.25-0.35 times that refined honey amount is thick paste quality that step (5) adds refined honey amount; Be more preferably: add 0.3 times that refined honey amount is clear paste quality).
7. the preparation method of the granule of the preparation as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) by Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf removing impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, add crude drug quality 0.3-0.5 rice vinegar doubly (preferred: the rice vinegar adding 0.4 times of crude drug quality), little fire heating is changed after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, after filtration, obtain Jiang Shui, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, be placed in Jiang Shuizhong and soak 8-18 minute (preferably: soak 10-16 minute; Be more preferably: soak 13 minutes), take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 10-18 minute (preferably: water proof heating 12-16 minute; Be more preferably: water proof heats 14 minutes), take out slow fire fried dry, cool;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, it is (preferred: Steam by water bath 20-24 minute to add washing water of rice Steam by water bath 16-28 minute; Be more preferably: Steam by water bath 22 minutes), take out and dry, pulverize together with step (1) (2) (3) made crude drug, make medicated powder;
(5) loaded in bag filter by step (4) gained medicated powder, the concentration adding medicated powder quality 8 times is the alcoholic solution of 80%, reflux, extract, twice, each persistent period be 1-2 hour (preferred: each persistent period is 1.2-1.8 hour; Be more preferably: each persistent period is 1.5 hours), collecting by filtration filtrate, and be recycled to without alcohol taste, heating is concentrated into the thick paste that relative density is 1.32, then adds adjuvant sucrose and dextrin, makes soft material, screens drying of sieving, and granulate is packed, and obtains granule.
8. the preparation method of preparation granules agent as claimed in claim 7, is characterized in that, it is (preferred: to screen 70-90 mesh sieve that step (5) screened 60-100 mesh sieve; Be more preferably: screened 80 mesh sieves).
9. the preparation method of the tablet of the preparation as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) by Folium Viticis Negundo, Flos clerodendri japonici and Flos Sauropi changiani leaf removing impurity, be placed in parch container, big fire stir-fries to micro-Jiao in crude drug surface, add crude drug quality 0.3-0.5 rice vinegar doubly (preferred: the rice vinegar adding 0.4 times of crude drug quality), little fire heating is changed after mixing thoroughly, boil and exhaust to soup, taking-up is dried in the air cool
(2) get Rhizoma Zingiberis and add water boil, after filtration, obtain Jiang Shui, Herba Crotalariae Ferrugineae, Herba Sedi Aizoon, Herba Equiseti Hiemalis, Herba Kummerowiae Striatae and Aleuritopteris farinsa (Forsk.) Fee rinse is clean, be placed in Jiang Shuizhong and soak 8-18 minute (preferably: soak 10-16 minute; Be more preferably: soak 13 minutes), take out and mix thoroughly with Sal, little fire stir-fries to drying, and taking-up cools;
(3) Exocarpium Citri Rubrum and Arillus Longan are cleaned remove impurity, be cut into filament, be placed in container, add yellow wine and refined honey mixing, put into steamer after mixing thoroughly, water proof heats 10-18 minute (preferably: water proof heating 12-16 minute; Be more preferably: water proof heats 14 minutes), take out slow fire fried dry, cool;
(4) get Radix Calystegiae sepii, Radix Ardisiae Crispae, Rhizoma Corydalis and Rhizoma Atractylodis and pick up clean impurity, it is (preferred: Steam by water bath 20-24 minute to add washing water of rice Steam by water bath 16-28 minute; Be more preferably: Steam by water bath 22 minutes), take out and dry, pulverize and sieve together with step (1) (2) (3) made crude drug, make medicated powder;
(5) step (4) gained medicated powder is added adjuvant, mix homogeneously, be crushed to oval tablet dosage form, obtain tablet.
10. the preparation method of formulation tablet as claimed in claim 9, is characterized in that, it is (preferred: to pulverize 100-120 mesh sieve that step (4) pulverized 80-140 mesh sieve; Be more preferably: pulverized 110 mesh sieves).
CN201510830239.6A 2015-11-25 2015-11-25 Lung diffusing and asthma relieving preparation for treating pneumoconiosis and preparing method thereof Pending CN105395714A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104689247A (en) * 2015-03-17 2015-06-10 季福玲 Traditional Chinese preparation for treating pneumoconiosis and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104689247A (en) * 2015-03-17 2015-06-10 季福玲 Traditional Chinese preparation for treating pneumoconiosis and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
周镔等: "消沉止咳汤治疗尘肺咳嗽的临床疗效观察", 《中国临床研究》 *

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