CN105395458A - Herbal composition and application thereof - Google Patents
Herbal composition and application thereof Download PDFInfo
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- CN105395458A CN105395458A CN201510933521.7A CN201510933521A CN105395458A CN 105395458 A CN105395458 A CN 105395458A CN 201510933521 A CN201510933521 A CN 201510933521A CN 105395458 A CN105395458 A CN 105395458A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/982—Reproductive organs; Embryos, Eggs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/985—Skin or skin outgrowth, e.g. hair, nails
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention provides a herbal composition and an application thereof; the composition includes radix asparagi and rhizoma rehmanniae or also includes ginseng; the composition can improve the activity of superoxide dismutase SOD and hyaluronic acid synthase HAS3 in skin fibroblasts by promoting proliferation of the skin fibroblasts so as to achieve good biological-activity antioxidant anti-aging and moisturizing effects, and can achieve antioxidant anti-aging and moisturizing double effects when added to cosmetics and/or skin care products.
Description
Technical field
The present invention relates to a kind of herbal compositions and application thereof, particularly relate to one and can strengthen human skin cell's superoxide dismutase SOD and hyaluronic acid synthetase HAS3 activity, thus there is the herbal compositions of antioxidant and anti-aging and biological activity moisturizing double effects, and the application in skin anti-aging and biological activity moisturizing.
Background technology
Superoxide dismutase (SuperoxideDismutase, SOD) orgotein is also called, it is a kind of active substance coming from life entity, the harmful substance that organism produces in metabolic processes can be eliminated, be regarded as the rubbish street cleaner in human body, SOD is the natural enemy of oxygen-derived free radicals, is a kind of important antioxidant enzymes.
Because modern life pressure, environmental pollution, various radiation and excess motion all can cause oxygen-derived free radicals to be formed in a large number, now confirm, the disease caused by oxygen-derived free radicals reaches kind more than 60.SOD can resist and the infringement blocked because oxygen-derived free radicals causes cell, and repairs damaged cell in time, restores the cell damage because free radical causes, and therefore, in biological antioxidant mechanism, the status of SOD is more and more important.
Skin is one of tissue that contact oxygen is maximum, and directly can suffer the invasion and attack of the physical factors such as ultraviolet, lonizing radiation and heat, also the injury of cosmetics, medicine, chemical substance, free radical and lipid peroxide etc. can be subject to, this outer skin is the same with other organs, leukocyte inflammation can occur and become the target of oxidative stress due to ischemic reperfusion.Therefore, SOD usually joins in skin care item and cosmetics as external additive and protects skin, at present, the SOD facial film utilizing SOD to manufacture, SOD honey, SOD snake powder etc., not lower hundreds of.As: Lu Yingxia etc. propose a kind of SOD cosmetics (Lu Yingxia etc., daily chemical industry, nineteen ninety-five, the 3rd phase, 8-10 page), with SOD extracting solution and hyaluronic acid for raw material; CN104997652A discloses the crease-resistant moisturizing liposome that a kind of SOD and hyaluronic acid are primary raw material and the cosmetics made thereof.
But exogenous sod also exists many defects, 1) cost is high; 2) SOD is as macromole, is difficult to be absorbed by the skin; 3) SOD easily degrade, inactivation, the half-life is short; 4) animality SOD has the potential risks such as exclusiveness, not easily preservation, hematopathy cross infection, is appealed to stop using by WHO; 5) vegetalitas SOD absorption difference, is difficult to enter skin and plays real effect, need to smear dosage greatly.Therefore, exogenous sod action effect is limited.
Hyaluronic acid (hyaluronic acid, HA) be a kind of acid mucopolysaccharide, in body, multiple important physiological function is demonstrated with the molecular structure of its uniqueness and physicochemical property, as lubricating joint, regulate the permeability of blood vessel wall, Function protein matter, Water-Electrolyte diffusion and running, promote wound healing etc.Significantly, hyaluronic acid has special water retention, it is the best material of the occurring in nature moisture retention that finds at present, be called as desirable nature moisturizing factor (Naturalmoisturizingfactor, NMF), such as: the pure hyaluronic acid aqueous solution of 2% can keep 98% moisture securely.Hyaluronic acid is a kind of multi-functional substrate, and hyaluronic acid is distributed widely in partes corporis humani position, and wherein skin is also containing a large amount of hyaluronic acids, and water retention is hyaluronic acid one of most important function in human body.Human skin maturation and ageing process also change along with hyaluronic content and metabolism, it can improve skin-nourishing metabolism, make that skin is tender, smooth, wrinkle removing, increase elasticity, prevent aging, be again good Percutaneous absorption enhancer while moisturizing.With other nutritional labelings with the use of, can play and promote the better effect of alimentation.
The method that hyaluronic acid refines has three kinds:
1, animal tissue: primary raw material is cockscomb and bovine vitreous body etc., with acetone or alcohol by raw material defat, dehydration, with distilled water immersion, filtration, then with sodium-chloride water solution and chloroformic solution process; Mixed liquor is obtained after adding trypsin insulation afterwards; Finally with ion-exchanger carry out processing, purification obtains the hyaluronic acid refined.This method extraction ratio extremely low (only about 1%), separation process is complicated, causes hyaluronic acid expensive, reaches 5000 dollars/kilogram, limits amount large in cosmetics and uses.
2, fermentable: using glucose as carbon source through fermentation liquid. ferment 48 hours in the medium, after fermentation ends, cross and filter mycelium and impurity, then namely obtain highly purified product with simple operationss such as the alcohol sedimentation method.The hyaluronic advantage adopting fermentation method manufacture is can by commodity design to set molecular size range.The key of fermentation method is the selection of strain, multiselect streptococcus, Lactococcus class etc.
3, chemosynthesis: adopt native enzyme polyreaction, first use polysaccharide polymer synthesis " hyaluronic acid oxaza amylene derivant ", then add water decomposition enzyme, produce the complex of derivant and enzyme, the last enzyme removed in 90 DEG C of reactant liquors wherein, obtains hyaluronic acid.Adopt synthetic method can greatly reduce hyaluronic manufacturing cost, but structure is more not consummate.
Be hyaluronic product equally, because raw material sources and make the difference of technology, have obvious impact to effect, the concentration of product can not as the reference selecting product, and purity, molecular weight, 3D stereochemical structure just can the direct hyaluronic soaking effects of impact.Usual molecular weight is larger, network structure is more complete, and soaking effect is better.In the streets skin care products, cosmetics are prevailing, but the homemade hyaluronic acid of many dealers, although low price, but it is not necessarily effective, even someone oral hyaluronic acid of carrying out, can resolve into carbohydrate and amino acid whose subsection molecule after the intestines and stomach absorbs, still must be transmitted through the steps such as autologous synthesis and just can be created in skin, connective tissue, its effect also must be given a discount.
Research shows, the cosmetics of the composition outstanding containing how usually all can not and to dermal partial, particularly because hyaluronic molecular weight is large, being only applied to epidermis is impossible by dermal absorption.Hyaluronic acid cosmetics only act on the skin surface smearing position, and skin surface hyaluronic acid contents in increasing, plays moist, moisture-keeping function, be locality with exogen.
Hyaluronic acid is originally just present in skin, can help skin in body and skin surface inhales to obtain moisture, can also strengthen the long water holding capacity of skin.After hyaluronic acid absorbs moisture, elastic fibers and collagen protein are in and are full of in moistening environment, therefore skin be provided with elasticity.But with age, in body, hyaluronic acid gradually reduces, the hyaluronic acid of skin from 25 years old later just run off, when 30 years old only remaining juvenile stage 65%, 60 years old time only remaining 25%.The moisture of skin also can be followed hyaluronic acid and scatter and disappear, and follows the string and gloss, gets off just to occur the catabiosis of wrinkle for a long time.In health, the hyaluronic acid of 50% is all distribute in skin, only needs the time, and the hyaluronic acid just complete metabolism of half in skin, therefore in Skin Cell, normal synthesis hyaluronic acid is extremely important for skin.
Summary of the invention
For current exogenous limitation of adding SOD and the application of hyaluronic acid in Skin Cell defying age and moisturizing, the invention provides the application of a kind of herbal compositions and described herbal compositions.
The present invention first aspect is to provide a kind of herbal compositions, preferably can strengthen human skin cell SOD and HAS3 activity thus reach the herbal compositions with antioxidant and anti-aging and biological moisture-keeping double effects, comprise and preferably consist of: Radix Asparagi, Radix Rehmanniae.
In an advantageous embodiment, described herbal compositions can also comprise Radix Ginseng, and preferably consists of: Radix Asparagi, Radix Rehmanniae and Radix Ginseng.
Wherein, in described herbal compositions, each herbal composition weight proportioning is preferably:
Radix Asparagi 1-5 part, is more preferably 2-4 part, as 2-3 part;
Radix Rehmanniae 2-5 part, is more preferably 2-4 part, as 3-4 part;
Radix Ginseng 0-10 part, is more preferably 1-8 part, is more preferably 3-6 part, as 4-5 part.
In an advantageous embodiment, described herbal compositions can also comprise one or more in following herbal component: Radix Notoginseng, Olibanum, Radix Platycodonis, Folium Artemisiae Argyi, the Radix Astragali, Flos Chrysanthemi, Rhizoma Polygonati, Fructus Lycii, Poria, Radix et Caulis Opuntiae Dillenii, Fructus Mangifera Indicae, Fructus Canarii albi, Herba Taraxaci, Radix Paeoniae, Rhizoma Chuanxiong, Paeonia suffruticosa, Herba Dendrobii, Radix Angelicae Sinensis, Flos Carthami, Fructus Chaenomelis, Pericarpium Granati, Rhizoma Zingiberis Recens, Aloe, Cortex cocois radicis Herba Saussureae Involueratae, Flos Inulae, tea, Ganoderma, Radix Glycyrrhizae, Semen Maydis, Fructus Forsythiae, Radix Puerariae, Semen Juglandis, Fructus Citri Limoniae, Fructus Cucumidis sativi, Fructus Melo, Radix Salviae Miltiorrhizae, Fructus Pruni pseudocerasi, Rhizoma Dioscoreae, Rhizoma Gastrodiae, Fructus Luffae, Semen Phaseoli, Fructus Caricae, Polianthes tuberosa L., Fructus Gleditsia, Cordyceps, Fructus Citri Sarcodactylis, jasmine, Herba Menthae, lavandula angustifolia, Chinese rose (comprising Flos Rosae Rugosae), Radix Zanthoxyli, Herba thymi vulgaris, Placenta caprae seu ovis hydrolyzed solution, Placenta Hominis, Fructus Hippophae, Cornu Cervi Pantotrichum, lac, Herb Gynostemmae Pentaphylli, Radix Arnebiae (Radix Lithospermi), Radix Oenotherae erythrosepalae, Sargassum, Mylabris tincture.
Wherein, in described herbal compositions, each herbal component can be water extract, ethanol extract, oily extract, supercritical CO
2any one or a few combination in extract, physical pulverization powder, extractum.
Described ethanol extract is preferably ethanol extraction, water extract, critical CO
2one or more combination in extract.
The present invention second aspect is to provide the application of any one herbal compositions above-mentioned.
Described herbal compositions is preferably applied to skin appearance face, is more preferably and is applied to the goods that preparation is coated on skin appearance face.
Wherein, herbal compositions of the present invention is applied to preparation cosmetics of everyday use, is preferably applied to and prepares cosmetics and/or skin care item.
Third aspect of the present invention is to provide a kind of goods being coated on skin appearance face, and described goods comprise any one herbal compositions above-mentioned.
Wherein, goods of the present invention are preferably cosmetics of everyday use, are more preferably cosmetics and/or skin care item.
Wherein, described goods, be preferably cosmetics of everyday use, be more preferably cosmetics and/or skin care item, preferably there is anti-skin-cell aging effect.
In an advantageous embodiment, described herbal compositions is scattered in base starting material as additive.
Wherein, described base starting material can be any one or a few in oily raw material, opaque raw material, colloid raw material, solvent materials.
Described oily raw material can be any one or a few combination in following base starting material: soybean oil, olive oil, almond oil, Oleum Ricini, Oleum Arachidis hypogaeae semen, Oleum Gossypii semen, Oleum Camelliae, Jojoba oil, American Avocado Tree oil, Oleum Cocois, Petiolus Trachycarpi oil, cocoa butter, Testa oryzae oil, Radix Oenotherae erythrosepalae oil, Semen Tritici aestivi germ oil, Fructus Maydis oil, palm wax, haze tallow, mink oil, turtle oil, Adeps Serpentis, egg oil, Adeps Bovis seu Bubali, horse fat, leaf fat, Adeps Cervi, lecithin, lanoline, Cera Flava, spermaceti, shellac wax, paraffin, vaseline, microwax, ceresine, squalane, lanolin wax, lanolin alcohol, lanolin alcohol carboxylate, acetylated lanolin, Acetylated lanolin alcohols., lanoceric acid, lanoceric acid carboxylate, Wool wax alcohols,ethoxylated, polyoxyethylene Pilus Caprae seu Ovis alcohol ether, polyoxypropylene lanonol ether, hydrogenated lanolin, alkoxylated hydrogenated lanoline, silicone oil (as: dimethicone, prestox silicone oil, methyl phenyl silicone), polysiloxanes-polyoxy alkyl block copolymers, Methyl Hydrogen Polysiloxane Fluid, Cn fitter acids and its ester, Cn fatty alcohol and ester thereof, wherein, n >=10, and be preferably 10-24, be more preferably 12-20, as 14,16,17,18.
Described Cn fatty acid is as lauric acid, myristic acid, Palmic acid, stearic acid, oleic acid, linoleic acid, erucic acid, capric acid.
Described Cn fatty alcohol is as lauryl alcohol, spermol, stearyl alcohol, isooctadecanol, oleyl alcohol, cocoanut oil alcohol.
Described Cn fatty acid ester, Cn aliphatic alcohol ester are as isopropyl myristate, myristyl myristate, tetradecyl alchohol lactate, hexadecanol lactate, isopropyl palmitate, the different monooctyl ester of palm, butyl stearate, Ethylhexyl stearate, stearic acid list glyceride, stearic acid macrogol ester, decyl oleate, caprylin, caprin, triolein.
Described opaque raw material can be any one or a few combination in following base starting material: Muscovitum, magnesium carbonate, titanium dioxide, zinc oxide powder, calcium hydroxide, calcium carbonate, Kaolin, calcium stearate, zinc stearate, magnesium stearate, Pulvis Talci, silicon dioxide, aluminium hydroxide, calcium pyrophosphate, calcium bicarbonate, bentonite.
Wherein, described glyceride stock can be any one or a few in vegetable oil raw material, animal oil raw material, mineral oil raw material, artificial oil raw material, semi synthetic base oils raw material.As: starch, cyclodextrin, xanthan gum, carrageenin, guar gum, arabic gum, tragacanth, agar, Lac, sodium alginate, gelatin, methylcellulose, ethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, poly-cellulose ether quaternary ammonium salt, polyvinyl alcohol, polyvinylpyrrolidone, sodium polyacrylate, polyoxyethylene, vinyl pyrrolidone/vinyl acetate copolymer, carbomer, Magnesiumaluminumsilicate, C
12-15alcohol benzoate.
Described solvent materials can be any one or a few combination in following base starting material: water, ethanol, propanol, isopropyl alcohol, isobutanol, ethylene glycol, 1,2-PD, cyclohexane extraction, dichlorodifluoromethane, tetrafluorodichloroethane, ethylene glycol monoethyl ether, diethylene glycol monoethyl ether, acetone, hexone, ethyl acetate, butyl acetate, pentyl acetate, dibutyl phthalate.
In an advantageous embodiment, described goods, be preferably cosmetics of everyday use, be more preferably in cosmetics and/or skin care item, can also comprise: any one or a few in surfactant, essence and spice, pigment, wetting agent, antiseptic, antioxidant, UV absorbent, chelating agen, astringent, permeation-promoter.
Wherein, described surfactant can be: 1) anion surfactant, as: C
12-14ammonium alkyl sulfate, C
12-14aliphatic alcohol polyethenoxy ether carboxylate, lauryl sulphate acid diethanolamine salt, C
12-14aESA, dodecyltriethanolamine sulfate, alcohol ether phthalic monoester sodium salt, acylated peptide, lauric monoethanolamide sodium sulfate, n-octyl alcohol polyethenoxy ether sulfosuccinate monoeaster, hexadecanol sulfosuccinate monoeaster, mono sulfosuccinates, mono succinate octadecyl ester disodium salt, alcohol ether mono sulfosuccinates, fatty alcohol-polyoxyethylene ether (sodium) sulfosuccinic acid monoesters ammonium salt, oleamide mono sulfosuccinates, N-acyl glutamic acid potassium salt, pyrrolidone sodium carboxylate, sodium polyacrylate, aliphatic alcohol polyoxyvinethene phosphate, fatty alcohol-polyoxyethylene ether phosphate monoester and salt thereof, fatty alcohol-polyoxyethylene ether phosphate monoester ethanolamine salt, alkylphenol polyoxyethylene phosphate monoester and salt thereof, nonyl phenol ether phosphoric acid monoesters ethanolamine salt, alkyl phosphate salt, mono laury alcohol phthalate salt, Zinc Undecenoate, anionic amino acid surfactant, N-C
12-18acyl glutamic acid sodium, N-lauroyl ALANINE sodium, N-stearyl monosodium glutamate, N-coconut acyl monosodium glutamate, N-mixing-in fat acyl glutamic acid list sodium salt, long linear alkyl aromatic ether sodium sulfonate TH, 2) non-ionic surface active agent, as: oleic alcohol polyoxyethylene ether (as emulsifying agent VO series), alkylphenol polyoxyethylene (as polyoxyethylene nonylphenol ether E series), polyoxyethylene stearic acid ester, ethylene glycol monostearate, diglycol stearate, polyethylene glycol mono stearate, polyethylene glycol stearate diester, Polyethylene Glycol bilaurate, glycerol distearate, glyceryl tristearate, sucrose stearate, polyoxyethylene glycerol ether monostearate, the two alkanol ester of N-lauroyl glutamate, benzoate fatty alcohol, sorbitan mono-fatty acid ester (span, Span, as Arlacel-20, sorbester p18, sorbester p38, Arlacel-80, Arlacel-83, Arlacel-85), polyoxyethylene ether sorbitan mono-fatty acid ester (tween, Tween, as tween 20, Tween-40, Tween-60, tween-61, tween 80), diethanolamine, triethanolamine, fatty monoethanol amide is (as coconut monoethanolamide, lauric monoethanolamide, palmitic monoethanolamide), cocoanut oil diethan olamide, lauric acid diethyl amide, methyl glucoside stearate, polyoxyethylene methyl glucoside stearate, ethylene glycol glucosides stearic acid ester, propylene-glycol-based glucoside stearate, C
8-16alkyl-glucoside, glycosylglycerol stearate, succinic acid lauryl alcohol monoesters, lauryl alcohol glyceride polyoxyethylene ether, stearic acid mannitol acid anhydride ester, polyoxyethylene ermine oil, ermine methyl oleate, ermine acid isopropyl, 3) cationic surfactant, as chlorination C
12-18alkyl trialkyl ammonium (as hexadecyl dimethyl alkylammonium, octadecyl trimethyl ammonium chloride, cetyltrimethylammonium chloride), chlorinated oil amido propyl dihydroxypropyl Dimethyl Ammonium, chlorination dihydroxypropyl dimethyl dodecyl base ammonium, dimethyldiallylammonium chloride/acrylamide copolymer, chlorinated oil amido propyl-2,3-dihydroxypropyl Dimethyl Ammonium, ethyl sulfuric acid oleamide propyl-dimethyl ethyl ammonium, the two C of chlorination
12-18base Dimethyl Ammonium, Onamer M 1 conditioner, M-505 polyquaternary amine-7 conditioner, ermine oleamide propyl group amine-chitosan, ermine oleamide propyl group amine-hydrolyzed protein, cationic protein peptide, guar gum-hydroxypropyl-trimethyl ammonium chloride salt, poly-cellulose ether quaternary ammonium salt, single triethanolamine oleate ester, DNP series, 4) zwitterionic surfactant, as C
12-18alkyldihydxyethyl betaines, N-C
12-18alkyl-N-(2-ethoxy)-N-(2-formamido ethyl) ammonium acetate, C
12-18alkoxyl hydroxypropyl betanin, oxidation Cocamidopropyl amine, cocos nucifera oil sodium isethionate, oxidation octadecyldimethylamine, cocos nucifera oil acyl diethanolamine amine oxide, N-alkyl-beta-amino propionyl diethanolamine, oxidation lauroyl propylamine, N-C
12-18acyl glutamic acid, ethoxy capric acid imidazolinium betaine, ethoxy myristic acid imidazolinium betaine, ethoxy Palmic acid imidazolinium betaine.
Wherein, described essence and spice can be selected from: 1) natural perfume material, as Common Wormwood oil, eucalyptus oil, Oleum Anisi Stellati, white lemon oil, Syringa amurensis concrete, Oleum Caryophylli, Flos micheliae Albae oil, Michelia concrete, Michelia leap oil, Cedar oil, Oleum menthae, atractylis concrete, melilotus extractum, petitgrain oil, Oleum Ocimi Gratissimi, Jasminum grandiflorum concrete, wintergreen oil, Radix Angelicae Sinensis oil, eumenol, lichenic acid, Gaultheria forrestii oil, Citrus aurantium L. var. amara Engl. Oil, Folium Dai Dai oil, hyacinth concrete, liquidambar concrete, Lignum cinnamomi camphorae oil, Sassafras oil, Radix Et Rhizoma Nardostachyos oil, osmanthus concrete, tangerine oil, Fructus Dauci Sativae oil, castoreum, Radix seu folium abelmoschi moschati oil, yellow blue oil, oil of Herba Pogostemonis, Oleum Cari, murraya paniculata concrete, cassie concrete, oil of ginger, mandarin oil, mentha piperita oil, chrysanthemum concrete, cymin oil, Ambra Grisea, Oleum Menthae Rotundifoliae, Zibethum, Chimonanthus praecox (L.) Link. oil, lily of the valley concrete, costus root oil, Aglaia odorata oil, geranium absolute, Oleum Rosae Rugosae, concrete of jasmine, oyster oil, crimson glory, ink chilli oil, lemon eucalyptus oil, Fructus Citri Limoniae oil, Radix Buddlejae Butterflybush extractum, machilus leaf oil, seed oil of Herba Apii graveolentis, Semen Myristicae oil, Oleum Cinnamomi, litsea cubeba oil, mink balsam tincture, narcissus concrete, pinke needle oil, tree moss concrete, jasmine extractum, Moschus moschiferous is fragrant, fragrant paste of muskrat, oleum Citri sinensis, Oleum Santali albi, tuberose oil, tuberose concrete, Flos Tagetis Erectae quintessence oil, fennel oil, blood Chinese juniper oil, citronella oil, Oleum Pelargonii Graveolentis, carnation oil, perilla oil, Salvia Sclare L.oil, nutgrass galingale oil, bergamot mint oil, vetiver oil, Herba Moslae oil, Herba Moslae extractum, Fructus Rubi corchorifolii Immaturus Flos Rosae Multiflorae caul-fat, Fructus Rubi corchorifolii Immaturus Flos rosae multiflorae extractum, Oleum lavandula angustifolia, laurel, ylang ylang oil, coriander seed oil, Herba Menthae Rotundifoliae oil, labdanum concrete, cinnamomum petrophilum oil, pomelo oil, orris oil, tobacco flower oil, citron petitgrain oil, gardenia concrete, Amorpha frutcosa oil, violet leaves concrete, guaiacol, 4-methyl guaiacol and 4, 4-ethyl guaiacol, natural vanillin, Camphora, 2) compound essence, as limonene, longifolene, second position caryophyllene, isolonglifolene, Isolongifolenone, isolongitolanone, hyacinthine, diphenyl-methane, diphenyl ether, m-phenoxy toluene, eugenol, isoeugenol, neroline bromelia, second position naphthol ethyl ether, p-Tolyl methyl ether, isoeugenol benzyl oxide, rose oxide, sandaler, narcissus ether (or jasmin oxide), ambrox, Cedramber, epoxycedrane, Eyring tal fibre, Eyring tal fibre N, 3-hexenol, decanol, lauryl alcohol, benzyl alcohol, phenethanol, para-methoxybenzyl alcohol, cinnamyl alcohol, dimethyl benzyl carbinol, geraniol, nerol, linalool, rhodinol, terpineol, citronellol, racementhol, Mentholum, Borneolum Syntheticum, cedar wood alcohol, cedralone, vertofix coeur, 3,4-dioxymethylene benzyl alcohol, Alpha-Methyl-3,4-dihydro methylene-benzene propionic aldehyde, the 2-tert-butyl group-4 methyl cyclohexanol, sclareol, santalol, 3-methyl-5-(2 ', 2 ', 3 '-trimethyl-cyclopentene-1 '-Ji) penta-2-alcohol, benzaldehyde, 1-Phenylethanone., phenylacetic acid, melilotal benzophenone, lauryl aldehyde, cinnamic aldehyde, cinnamic acid, α-amyl group-beta-phenyl acrylic aldehyde, α-hydrocinnamicaldehyde, lilestralis, LYRAL, cyclamen aldehyde, 3,4-methylenedioxy benzaldehyde, 3,7-dimethyl-6-octenal, 3,7-dimethyl-7-hydroxyl octanal, citral, second position homocyclocitral, evertal, myrac aldehyde, 3-methoxy-4-hydroxybenzaldehyde, α-dihydro turkone, β-Damascenone, ionoionone, 6-methyl ionone, nerone, carvone, piperonylacetone, raspberry ketone, medicinal herbs ketone, cis-jasmone, enanthaldehyde Glycol Acetal, phenylacetaldehyde dimethyl acetal, octacetal, α amyl cinnamic aldehyde dimethylacetal, citral dimethyl acetal, citral diethyl acetal, anisaldehyde dimethylacetal, mushroom aldehyde, cyanophyll, fenxizisu, apple ester, jeep ketal, geranyl formate, citronellyl formate, Aphermate, Leaf Acetate, benzyl acetate, phenethyl acetate, cinnamyl acetate, terpinenyl aceatae, borneol acetate, linalyl acetate, geranyl acetate, vertenex, verdox, vetacetyl, Amboryl acetate, acetic acid Aphermate, acetic acid decahydronaphthalene ester, Cedryl acetate., geranyl propionate, acetic acid trichloromethyl benzene methyl, benzyl butyrate, butanoic acid folic alcohol ester, geranyl butyrate, 2 methyl valeric acid phenethyl ester, p-cresyl isobutyrate, methyl 2-nonenoate, ethyl benzoate, essence of Niobe, benzoic acid folic alcohol ester, benzyl benzoate, ethyl phenylacetate, p-cresyl phenylacetate, ethyl cinnamate, butyl salicylate, isonefolia, isoamyl salicylate, salicylic acid folic alcohol ester, 1-Hexyl salicylate, benzyl salicylate, phenylethyl salicylate, salicylic acid cyclohexyl, Jasmonate, jasmonyl, 2-amyl group Ketocyclopentane methyl acetate, anrantiol, nonyl lactone, gamma-undecalactone, coumarin, indole, 3-methylindole, 3,7-dimethyl-2,6-octadiene nitrile, to methoxy benzonitrile, musk xylene, musk ketone, 2,6-dinitro-3-methoxyl-4-t-butyltoluene, 1,1-dimethyl-4-acetyl group-6-tert-butyl group indane, hexamethyl tricyclic isochroman musk, 1,1,2,3,3,6-hexamethyl-5-acetyl group indane, Moschus-T, Moschus-M, Moschus-L, Moschus-F, 11-cyclooxahexadecanolide, tonalid, 3) essence, rose essence, jasmin essence, sandalwood fragrance, michelia essence.
Wherein, described pigment can be selected from one or more in following component: zirconium dioxide, lead acetate, silver nitrate, chlorophyll, copper chlorophyll, ferric ferrocyanide, guanine, fast red, Food Red I, vat red I, carmine, edible Fructus Myricae rubrae is red, edible bright cherry-red, Food Red 17, amaranth, fast green, food Huang 3, Tatrazine, edible Sudan yellow, Food Indigo, food indigo plant 2, phloxine, beta-carotene, Flos Impatientis, gardenia red pigment, gardenia green pigment, gardenia blue pigment, Gardenia Yellow, odenite pearlescent pigment, iron oxide red, iron oxide yellow, iron oxide black, chrome oxide green, Bismuth Oxychloride, alkaline pink, Vermilion R, D C Yellow No. 10, shikonin, lac color, ultramarine, acid red 87, ACID GREEN 25, acid fluorescence yellow, acid orange 7, bronze red 53, lithol red BK directions, lithol rubine 2R, solid orange forever.
Wherein, described antiseptic can be selected from the one or more combination in following component: sorbic acid and salt, propionate, p-Hydroxybenzoate, benzyl alcohol, benzoic acid and salt thereof, CMIT ,-MIT, Kazon, imidazolidinyl urea, dehydroacetic acid and salt, sodium sulfite, sodium sulfite, sodium pyrosulfite, 2,2-bromo-2-nitro-1,3-propylene glycol (Bronopol), arabo-ascorbic acid and salt, kojic acid and ester thereof, Azelaic Acid, usnic acid, resorcinol.
Wherein, described antioxidant can be selected from the one or more combination in following component: SOD, Butylated hydroxyanisole, epicatechol gallate, ascorbic acid and salt thereof, arabo-ascorbic acid and salt thereof, sitosterol, rutin, tocopherol.
Wherein, described wetting agent can be selected from the one or more combination in following component: 1,2-butanediol, sorbitol, xylitol, glycerol, lactate, Polyethylene Glycol, DL-pyrrolidone carboxylic acid salt, D-Glucose, kojic acid and ester thereof, uric acid, orotic acid, pectic acid, laminine, collagen protein, trehalose, 12, hydroxy stearic acid cholesterol ester.
Wherein, described UV absorbent can be selected from the one or more combination in following component: pyridoxine hydrochloride, kojic acid and ester thereof, rutin, barbaloin, coffee propylhomoserin, hesperetin, Escalol 587,2-ethylhexyl to dimethylamino benzoic ether, 2-Parsol MCX, phenyl salicytate,
base o-aminobenzoa, ESCALOL 567, BP-4,2-hydroxyl-4-octyloxybenzophenone.
Wherein, described chelating agen can be selected from the one or more combination in following component: EDETATE DISODIUM, Bispyrithione zinc, sodium thiosulfate.
Wherein, described astringent can be selected from the one or more combination in following component: zinc phenolsulfonate, polymeric aluminum chloride, aluminum sulfate, aluminium potassium sulfate, zinc sulfate, aluminum chloride, zinc chloride, Prepared-Calamine.
Wherein, described permeation-promoter can be selected from the one or more combination in following component: dimethyl sulfoxide, 1-orthododecyl nitrogen heterocyclo heptane-2-ketone, 2-ethylaminoethanol.
Wherein, described pH value regulator can be selected from the one or more combination in following component: tartaric acid, lactic acid, boric acid, succinic acid.
In an advantageous embodiment, described cosmetics of everyday use, to be preferably in cosmetics and/or skin care item, can also nutritive additive to be comprised.
Wherein, described nutritive additive can be selected from the one or more combination in following component: chitin, chitosan, silk peptide, fibroin, lecithin, epithelical cell growth factor, trehalose, lactose, Margarita powder, collagen protein, collagen hydrolysate, hyaluronic acid and salt thereof, egg membranogen, plant sterol, lysozyme chloride, sodium chondroitin sulfate, Lac regis apis, propolis, Mel, glycyrrhizic acid, enoxolone, gamma-Linolenic acid, kojic acid and ester thereof, gibberellin, glycine, L-Aspartic acid and salt thereof, CYSTINE and salt thereof, DL-Alanine, Serine, DL-serine, L-Methionine, DL-methionine, L lysine hydrochloride, L-Thr, inositol, maltol, pantothenate, D-panthenol, retinyl acetate, allantoin, pyridoxine hydrochloride, cortisone, nicotiamide, vitamin, estrogen, haematoxylin, uric acid, orotic acid, barbaloin, Azelaic Acid, rosin acid, usnic acid, laminine, thymosin, rubican, limonene, baicalein, deoxycholic acid, lignum-vitae cornel, hesperetin, tannic acid, selenium sulfide, theasaponin, triethyl citrate, butylated hydroxytoluene, phytic acid, polychloride dimethyldiallylammonium.
Herbal compositions provided by the present invention, raising superoxide dismutase (SOD) and hyaluronic acid synthetase (HAS3) horizontal in have remarkable result, the propagation of fibroblast can be promoted, can be used as goods or additive application in food, medicine, cosmetics and/or skin care item, play the double effects of defying age and biological moisture-keeping.
The present invention's book on Chinese herbal medicine complex, can strengthen Skin Cell self and synthesize hyaluronic ability, promotes human skin cell self synthesis hyaluronic acid, and the hyaluronic acid exempting exogenous interpolation absorbs and waits application problem with irritated.
Accompanying drawing explanation
Fig. 1 is the present invention's book on Chinese herbal medicine compositions and Radix Asparagi extract, Radix Rehmanniae extract, Radix Ginseng extract contrast fibroblast proliferative effect ability;
Fig. 2 be the present invention book on Chinese herbal medicine compositions and Radix Asparagi extract, Radix Rehmanniae extract, Radix Ginseng extract in Skin Cell SOD activity influence ability contrast;
Fig. 3 be the present invention book on Chinese herbal medicine compositions and Radix Asparagi extract, Radix Rehmanniae extract, Radix Ginseng extract in Skin Cell hyaluronic acid synthetase HAS3 activity influence ability contrast.
Detailed description of the invention
the preparation of Radix Asparagi extract
Radix Asparagi rhizome is pulverized, and with the water backflow lixiviate of 10 times of weight, extracting solution (0.04 to 0.08MPa, 75 ± 6 DEG C) under condition of negative pressure removes solvent, and extraction obtains extract solid, after spraying dry, pulverizes, sieves.
Radix Asparagi extract also can be buied from market, or according to the standard in China's " pharmacopeia ", method preparation.
the preparation of Radix Rehmanniae extract
Radix Rehmanniae is pulverized, and with the water extraction of 8 times of weight, under condition of negative pressure, (0.04 to 0.08MPa, 75 ± 6 DEG C) are concentrated into proportion to extracting solution is 1.07 to 1.09g/cm
3(75 ± 6 DEG C), after spraying dry, pulverize, sieve.Dihuang polysaccharide weight content >=50%.
Radix Rehmanniae extract also can be buied or prepare according to the standard in China's " pharmacopeia ", method from market.
the preparation of Radix Ginseng extract
Rhizome of Radix Ginseng is pulverized, 70% alcohol reflux, dry, pulverize, sieves after concentrated.Ginsenoside total weight content >=8%.
Radix Ginseng extract also can be buied or prepare according to the standard in China's " pharmacopeia ", method from market.
Embodiment 1, the compositions of Radix Asparagi, Radix Rehmanniae, Radix Ginseng extract and three kinds of extracts is tested the effect of proliferative activity of fibroblasts
material and reagent
methods and steps
With the cell monolayer of trypsinization logarithmic (log) phase, by cell harvesting in cell culture fluid.
1000rpm, centrifugal 2min, abandons supernatant.With culture fluid Eddy diffusion cell, counting.Concentration to 2.5 × 10 of adjustment cell suspension
3to 50 × 10
3individual/mL, specifically determines with the speed of growth of cell line.
Spread 96 orifice plates, every porocyte suspension 135 μ L.The final cell hole count spread depends on sample number, the multiple hole of 3, each sample.Finally leave 3 holes and do not spread cell, as blank.
96 orifice plates are placed in 37 DEG C containing 5%CO
2cell culture incubator in hatch 24h.
After testing sample dilution being added by culture medium, continue to cultivate 48h.
Every hole adds the CCK8 of 20 μ L, continues cultivation 0.5 to 4h.
Jiggle 96 orifice plates, under 450nm, measure absorbance by microplate reader.
test result
Table 1, Radix Asparagi, Radix Rehmanniae, Radix Ginseng extract and compositions thereof are to fibroblast cultivation effect
Can find out with reference to Fig. 1 and table 1, the Radix Asparagi extract of 0.1mg/ml and Radix Rehmanniae extract can both promote fibroblastic propagation, and Radix Ginseng extract fibroblast proliferation does not almost act on.Meanwhile, the compositions of Radix Asparagi, Radix Rehmanniae, Radix Ginseng extract can promote fibroblastic propagation.
Embodiment 2, the compositions of Radix Asparagi, Radix Rehmanniae, Radix Ginseng extract and three kinds of extracts is on the impact of SOD level in skin flbroblast
material and reagent
methods and steps
Bed board kind cell: with the cell monolayer of trypsinization logarithmic (log) phase, by cell harvesting in cell culture fluid.With culture fluid Eddy diffusion cell, counting.Concentration to 5 × 10 of adjustment cell suspension
4individual/mL, specifically determines with the speed of growth of cell line.Spread 24 orifice plates, every porocyte suspension 0.9mL.The final cell hole count spread depends on sample number, the multiple hole of 4, each sample.
Add determinand: continue to cultivate 12h after adding determinand.
Extract cell RNA, extract the ultrapure RNA of sample total serum IgE and extract test kit, every hole adds 150 pl of lysis liquid cell lysis 2 minutes, and in conjunction with RNA5 minute, wash once with Washbuffer1, WashBuffer2 washs 2 times, finally uses 30 microlitres without RNA enzyme water elution.
CDNA reverse transcription, gets 400ngRNA, 3.5 microliter of buffer liquid, 10 microlitre system reverse transcriptions.
ABI7500 detects real time fluorescent quantitative.
Be that internal reference calculates adjustment multiple with GAPDH, adopt 2-△ △ CT method to carry out the relative quantitative assay of data.The horizontal F computing formula of SOD is:
F=2 × to be measured group of object target Average Ct values-to be measured group house keeper's internal reference [Average Ct values]-matched group object target Average Ct values-matched group house keeper internal reference { [Average Ct values] }
test result
Table 2, Radix Asparagi, Radix Rehmanniae, Radix Ginseng extract and compositions thereof are on SOD level impact in skin fibroblast
Can be found out by Fig. 2 and table 2, the Radix Asparagi extract of 0.1mg/ml, Radix Rehmanniae extract, Radix Ginseng extract and the present invention's book on Chinese herbal medicine compositions can significantly improve SOD level in skin flbroblast, wherein the present invention's book on Chinese herbal medicine extract combination activity is the highest, shows stronger compatibility synergism.
Comprehensive above test result can draw, the present invention's book on Chinese herbal medicine compositions has remarkable result in promotion skin flbroblast is bred and raising SOD is horizontal, therefore, the present invention's book on Chinese herbal medicine compositions is added in skin care item and can play antidotal effect.
Embodiment 3, compositions biological activity moistening effect test (skin hyaluronic acid synthetase HAS3 horizontal checkout) of Radix Asparagi, Radix Rehmanniae, Radix Ginseng extract and three kinds of extracts
material and reagent
methods and steps
Bed board kind cell: with the cell monolayer of trypsinization logarithmic (log) phase, by cell harvesting in cell culture fluid.With culture fluid Eddy diffusion cell, counting.Concentration to 5 × 10 of adjustment cell suspension
4individual/mL, specifically determines with the speed of growth of cell line.Spread 24 orifice plates, every porocyte suspension 0.9mL.The final cell hole count spread depends on sample number, the multiple hole of 4, each sample.
Add determinand: continue to cultivate 12h after adding determinand.
Extract cell RNA, extract the ultrapure RNA of sample total serum IgE and extract test kit, every hole adds 150 pl of lysis liquid cell lysis 2 minutes, and in conjunction with RNA5 minute, wash once with Washbuffer1, WashBuffer2 washs 2 times, finally uses 30 microlitres without RNA enzyme water elution.
CDNA reverse transcription, gets 400ngRNA, 3.5 microliter of buffer liquid, 10 microlitre system reverse transcriptions.
ABI7500 detects real time fluorescent quantitative.
Be that internal reference calculates adjustment multiple with GAPDH, adopt 2-△ △ CT method to carry out the relative quantitative assay of data.HAS3 level (F) computing formula is:
F=2 × to be measured group of object target Average Ct values-to be measured group house keeper's internal reference [Average Ct values]-matched group object target Average Ct values-matched group house keeper internal reference { [Average Ct values] }
result
Table 3, Radix Asparagi, Radix Rehmanniae, Radix Ginseng extract and compositions thereof are on HAS3 level impact in skin fibroblast
Can be found out by Fig. 3 and table 3, the Radix Asparagi extract of 0.1mg/ml and the present composition can significantly improve the level of hyaluronic acid synthetase in skin flbroblast, water retention is hyaluronic acid one of most important function in human body, therefore, the present composition can realize good skin moisturization.And compared to independent three kinds of components, the present composition, in raising skin fibroblast HSA3 horizontal capability, is greater than the simple superposition of effect when three kinds of components are used alone, namely obtains synergy.
In sum, the present composition can reach good antioxidation and anti-aging effects by improving SOD activity in skin fibroblast, promote the hyaluronic acid enzyme level of Skin Cell own simultaneously, there is good biological activity moistening effect, add the double effects that can reach antioxidant and anti-aging and moisturizing in cosmetics/skin care item to.
Be described in detail specific embodiments of the invention above, but it is just as example, the present invention is not restricted to specific embodiment described above.To those skilled in the art, any equivalent modifications that the present invention is carried out and substituting also all among category of the present invention.Therefore, equalization conversion done without departing from the spirit and scope of the invention and amendment, all should contain within the scope of the invention.
Claims (10)
1. a herbal compositions, is characterized in that, comprises Radix Asparagi, Radix Rehmanniae.
2. herbal compositions according to claim 1, is characterized in that, also comprise Radix Ginseng.
3. herbal compositions according to claim 1 and 2, is characterized in that, in described herbal compositions, each herbal composition weight proportioning is:
Radix Asparagi 1-5 part, Radix Rehmanniae 2-5 part, Radix Ginseng 0-10 part.
4. herbal compositions according to claim 3, it is characterized in that, described herbal compositions also comprises one or more in following herbal component: Radix Notoginseng, Olibanum, Radix Platycodonis, Folium Artemisiae Argyi, the Radix Astragali, Flos Chrysanthemi, Rhizoma Polygonati, Fructus Lycii, Poria, Radix et Caulis Opuntiae Dillenii, Fructus Mangifera Indicae, Fructus Canarii albi, Herba Taraxaci, Radix Paeoniae, Rhizoma Chuanxiong, Paeonia suffruticosa, Herba Dendrobii, Radix Angelicae Sinensis, Flos Carthami, Fructus Chaenomelis, Pericarpium Granati, Rhizoma Zingiberis Recens, Aloe, Cortex cocois radicis Herba Saussureae Involueratae, Flos Inulae, tea, Ganoderma, Radix Glycyrrhizae, Semen Maydis, Fructus Forsythiae, Radix Puerariae, Semen Juglandis, Fructus Citri Limoniae, Fructus Cucumidis sativi, Fructus Melo, Radix Salviae Miltiorrhizae, Fructus Pruni pseudocerasi, Rhizoma Dioscoreae, Rhizoma Gastrodiae, Fructus Luffae, Semen Phaseoli, Fructus Caricae, Polianthes tuberosa L., Fructus Gleditsia, Cordyceps, Fructus Citri Sarcodactylis, jasmine, Herba Menthae, lavandula angustifolia, Chinese rose, Radix Zanthoxyli, Herba thymi vulgaris, Placenta caprae seu ovis hydrolyzed solution, Placenta Hominis, Fructus Hippophae, Cornu Cervi Pantotrichum, lac, Herb Gynostemmae Pentaphylli, Radix Arnebiae (Radix Lithospermi), Radix Oenotherae erythrosepalae, Sargassum, Mylabris tincture.
5. herbal compositions according to claim 3, is characterized in that, in described herbal compositions, each herbal component is selected from water extract, ethanol extract, oily extract, supercritical CO
2any one or a few combination in extract, physical pulverization powder, extractum.
6. an application for herbal compositions as claimed in claim 1, is characterized in that, described herbal compositions is applied to the goods that preparation is coated on skin appearance face.
7. application according to claim 6, is characterized in that, described goods are cosmetics and/or skin care item.
8. the application according to claim 6 or 7, is characterized in that, described herbal compositions is scattered in base starting material as additive, described substrate be selected from oily raw material, opaque raw material, colloid raw material, solvent materials any one or a few.
9. the application according to claim 6 or 7, it is characterized in that, described goods also comprise: any one or a few in surfactant, essence and spice, pigment, wetting agent, antiseptic, antioxidant, UV absorbent, chelating agen, astringent, permeation-promoter, nutritive additive.
10. be coated on the goods in skin appearance face, it is characterized in that, comprise herbal compositions according to claim 1.
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