CN105381310A - Traditional Chinese medicine preparation for treating phthisis and preparing method thereof - Google Patents
Traditional Chinese medicine preparation for treating phthisis and preparing method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine preparation for treating phthisis and a preparing method thereof. The traditional Chinese medicine preparation is prepared from Jew's ears on mulberry trees, rhizomes of longspurred fairybells, cynanchum thesioides, rhynchosia volubilis, pagoda tree fruits, gymnadenia conopsea, winged yam rhizomes, tribulus terrestris, arenaria brevipetala, patrinia heterophylla, jasminum laurifolium and arthraxon hispidus. The traditional Chinese medicine preparation for treating phthisis has the advantages of being combined with the western medicine treatment scheme, and being safe and convenient to use, good in treating effect, free of toxic and side effects and simple in preparing technology.
Description
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to one and treat phthisical Chinese medicine preparation and preparation method thereof.
Background technology
Tuberculosis is the chronic infectious disease caused by mycobacterium tuberculosis, can invade and many internal organs, and form pulmonary tuberculosis (pulrnonarytuberculosis) with pulmonary involvement the most common, discharge of bacteria patient is its important source of infection.The mankind infect mainly through sucking nucleus droplet (distributing when tuberculosis patient cough, sneeze).The tulase of invasion respiratory tract is engulfed by pulmonary alveolar macrophage.Pulmonary tuberculosis (pulmonarytuberculosisPTB) is the pneumonia infection disease caused by mycobacterium tuberculosis.It is the disease of serious threat human health.The lunger of the source of infection of mycobacterium tuberculosis (be called for short tulase, lower with) mainly discharge of bacteria, passes through respiratory infectious.Healthy People infects tulase and might not fall ill, and only just falls ill when immunity of organisms declines.World Health Organization (WHO) (WHO) statistics shows, tuberculosis 800 ~ 1,000 ten thousand occurs every year in the whole world, about has 3,000,000 people to die from tuberculosis every year, is the single infectious disease that the number of causing death is maximum.Within 1993, WHO announces " the global tuberculosis state of emergency ", thinks that tuberculosis has become the important public health problem in the whole world.China is one of country that tuberculosis epidemic situation is the most serious in the world.
Pulmonary tuberculosis belongs to the category of Chinese medicine " pulmonary tuberculosis ", " asthenia ", " deficient ".The pathogeny of pulmonary tuberculosis is first corrode lung body after the invasion of consumptive disease worm, and lung body is impaired, consumption of lung-YIN, and lung loses and moistens.Morbidity is for years on end afterwards, obstinate disease, and lung yin is more empty, continues, and the deficiency of YIN is given birth to interior-heat and causes hyperactivity of fire caused by deficiency of YIN, or because of deficiency of YIN leading to consumption of QI, the deficiency of YIN can not cause deficiency of both QI and YIN by activating QI, very then deficiency of YIN affecting YANG.Pulmonary tuberculosis is prolonged for a long time, and the change of disease that continues is in other internal organs, particularly kidney and spleen.Severe one can develop into lung, spleen, the dirty friendship of kidney three thanks to because essence and blood loses.Therefore its pathologic feature of primary disease is based on the deficiency of YIN, but the deficiency of YIN can cause hyperactivity of fire, the deficiency of vital energy or deficiency of both YIN and YANG.
Summary of the invention
Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides one in conjunction with western medical treatment scheme, effective and phthisical Chinese medicine preparation of the treatment had no side effect and preparation method thereof to tuberculosis treatment.
In order to solve the problems of the technologies described above, the invention provides one and treat phthisical Chinese medicine preparation, described Chinese medicine preparation comprises following raw medicinal material: Mulberry, Rhizoma Dispori Calcarati, Herba Cynanchi Thesioidis, Herba rhynchosiae volubilis, the Fructus Sophorae, Rhizoma Gymnadeniae, Rhizoma Dioscoreae Alatae, Fructus Tribuli, Herba arenariae kansuensis, Radix Patriniae heterophyllae, Herba Jasmini laurifolii and Herba Arthraxonis Hispidi.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Mulberry 30 ~ 40 parts, Rhizoma Dispori Calcarati 15 ~ 30 parts, Herba Cynanchi Thesioidis 20 ~ 30 parts, Herba rhynchosiae volubilis 15 ~ 25 parts, the Fructus Sophorae 10 ~ 20 parts, Rhizoma Gymnadeniae 5 ~ 15 parts, Rhizoma Dioscoreae Alatae 15 ~ 30 parts, Fructus Tribuli 20 ~ 30 parts, Herba arenariae kansuensis 20 ~ 35 parts, Radix Patriniae heterophyllae 10 ~ 20 parts, Herba Jasmini laurifolii 15 ~ 25 parts and Herba Arthraxonis Hispidi 20 ~ 30 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Mulberry 30 ~ 35 parts, Rhizoma Dispori Calcarati 20 ~ 25 parts, Herba Cynanchi Thesioidis 25 ~ 30 parts, Herba rhynchosiae volubilis 15 ~ 20 parts, the Fructus Sophorae 10 ~ 15 parts, Rhizoma Gymnadeniae 5 ~ 10 parts, Rhizoma Dioscoreae Alatae 20 ~ 25 parts, Fructus Tribuli 25 ~ 30 parts, Herba arenariae kansuensis 20 ~ 25 parts, Radix Patriniae heterophyllae 10 ~ 15 parts, Herba Jasmini laurifolii 20 ~ 25 parts and Herba Arthraxonis Hispidi 25 ~ 30 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Mulberry 32 parts, Rhizoma Dispori Calcarati 25 parts, Herba Cynanchi Thesioidis 26 parts, Herba rhynchosiae volubilis 19 parts, the Fructus Sophorae 12 parts, Rhizoma Gymnadeniae 10 parts, Rhizoma Dioscoreae Alatae 22 parts, Fructus Tribuli 29 parts, Herba arenariae kansuensis 21 parts, Radix Patriniae heterophyllae 15 parts, Herba Jasmini laurifolii 21 parts and Herba Arthraxonis Hispidi 28 parts.
When the dosage form of described Chinese medicine preparation is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:
The first step, Mulberry, Rhizoma Dispori Calcarati, Herba Cynanchi Thesioidis and Herba rhynchosiae volubilis are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Herba arenariae kansuensis, Radix Patriniae heterophyllae, Herba Jasmini laurifolii and Herba Arthraxonis Hispidi are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
Beneficial effect of the present invention: the Chinese medicine preparation that pulmonary tuberculosis of the present invention uses, in conjunction with western medical treatment scheme, safe and convenient to use, therapeutic effect is good, has no side effect, and preparation technology is simple.
Detailed description of the invention
The invention provides one and treat phthisical Chinese medicine preparation, Chinese medicine preparation comprises following raw medicinal material: Mulberry, Rhizoma Dispori Calcarati, Herba Cynanchi Thesioidis, Herba rhynchosiae volubilis, the Fructus Sophorae, Rhizoma Gymnadeniae, Rhizoma Dioscoreae Alatae, Fructus Tribuli, Herba arenariae kansuensis, Radix Patriniae heterophyllae, Herba Jasmini laurifolii and Herba Arthraxonis Hispidi.
The pharmacology of various raw medicinal material is as follows:
Mulberry: Auricularia, Mulberry chicken on parasitism, Mulberry Xiao, Mulberry on [another name] Mulberry bacterium, wooden wheat, Mulberry.[source] medical material Ji Yuan: for Tremellaceae Tremella and Auriculariaceae Auricularia must the sporophore of edible fungus.[nature and flavor] are sweet; Flat.[return through] liver; Spleen channel.[function cures mainly] cooling blood for hemostasis; Blood circulation promoting and dispersing pathogen accumulation.Main epistaxis; Hematuria; Have blood in stool; Hemorrhoidal bleeding; Metrorrhagia; Sore throat; Lump in the abdomen.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Dispori Calcarati: [source] medical material Ji Yuan: for liliaceous plant is apart from rhizome or the root of spending cantonese fairy bells.[nature and flavor] sweet in the mouth; Property is put down.[function cures mainly] QI invigorating is cloudy; Lung moistening is dry.The main deficiency of both vital energy and Yin dryness of the lung; Osteopyrexia and fever; Soreness of the waist and knees; Night sweat.[take passages " China's book on Chinese herbal medicine "
Herba Cynanchi Thesioidis: [another name] female green grass or young crops, angle, mountain, Radix Pachyrhizi Erosi, sheep not milk fruit, little Fructus Luffae, floating wooden dipper, old melon gourd dipper, husky grandmother, horse milk milk, husky Herba Euphorbiae Humifusae, spire cynanchum auriculatum Royle ex Wight, passeris montani saturati melon, arhat grass, Semen Pachyrhizi Erosi, careless, the sheep of Pueraria lobota, Radix Pachyrhizi Erosi wooden dipper, interwined dragon grass, cattle tip melon, sheep milk cling to milk.[source] medical material Ji Yuan: be the herb of dicotyledon medicine asclepiadaceae plant spire Rhizoma Cynanchi Stauntonii.[nature and flavor] sweet in the mouth; Cool in nature.[return through] lung meridian.[function cures mainly] tonifying the lung gas; Resolving heat and reducing pathogenic fire; Promoting the production of body fluid to quench thirst; Anti-inflammatory analgetic.Main hyperactivity of deficient fire; Have sore throat; Deficiency of both vital energy and Yin; Mental fatigue is forgetful; Fidgets due to deficiency is thirsty; Dizzy insomnia; Puerperal asthenia; Hypogalactia.[extracts] " China's book on Chinese herbal medicine "
Herba rhynchosiae volubilis: [another name] Crafts-Co., deer bean, terrible Radix Sophorae Tonkinensis, Resina garciniae bean, black eyeball pearl, light eye bell bell rattan, mountain Semen sojae atricolor, terrible eyes, Glycine tomentella.[source] medical material Ji Yuan: be the stem and leaf of leguminous plant Herba rhynchosiae volubilis.[nature and flavor] bitter in the mouth; Acid; Property is put down.[return through] stomach; Spleen; Liver Channel.[function cures mainly] expelling wind and removing dampness; Invigorate blood circulation; Removing toxic substances.Main air pain of dampness syndrome; Headache; Toothache; Lumbar vertebrae pain; Abdominal pain due to blood stasis; Lochiopyra; Scrofula; Carbuncle sore tumefacting virus; Traumatic injury; Scald.[each discussion] Jiangxi " medical herbs handbook ": eliminate the phlegm, removing toxic substances, parasite killing, wind-damp dispelling, and vim and vigour.Control acute appendicitis, scrofula, headache, ophthalmalgia, stomachache.[extracts] " China's book on Chinese herbal medicine "
The Fructus Sophorae: [source] this product is the dry mature fruit of leguminous plant Chinese scholartree.[nature and flavor] are bitter, cold.[return through] returns liver, large intestine channel.[function cures mainly] clearing away heat-fire, cooling blood for hemostasis.Have blood in stool for intestinal heat, hemorrhoid swell hemorrhage, and liver-heat is had a headache, dizzy conjunctival congestion.[extracts] " Chinese Pharmacopoeia "
Rhizoma Gymnadeniae: [another name] hides Radix Notoginseng, Fructus Citri Sarcodactylis ginseng, blue, palm ginseng, hands ginseng, negative and positive ginseng.[source] medical material Ji Yuan: be the tuber of orchid Rhizoma Gymnadeniae or gymnadenia crassinervis Finet.[nature and flavor] are sweet; Flat.[return through] lung; Spleen; Stomach warp.[function cures mainly] relieving cough and asthma; Yishen Jianpi; Regulate the flow of vital energy and blood; Pain relieving.Main cough and asthma due to lung deficiency; Asthenia is become thin; Neurasthenia; Suffer from a deficiency of the kidney lassitude loin and legs; Sexual impotence; Spermatorrhea; Frequent micturition; Chronic hepatitis; Chronic diarrhea; Lose blood; Leukorrhagia; Breast is few; Traumatic injury.[each discussion] 1. " Chinese herbal medicine is commonly used in Sichuan ": blood yiqi, promoting the production of body fluid to quench thirst.Control cough and asthma due to lung deficiency, chronic consumptive disease is won thin, hypogalactia juice.2. " Shaanxi Chinese herbal medicine ": strengthening by means of tonics, spleen reinforcing lung moistening, calms the nerves relieving convulsion, QI invigorating pain relieving.Control physical weakness, neurasthenia, impairment caused by overstrain, cough, asthma.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Dioscoreae Alatae: [another name] multitude hole potato, yampi, potato, sole potato, chicken coop potato, go cake Rhizoma Dioscoreae.[source] medical material Ji Yuan: be the tuber of Dioscoreaceae plant ginseng potato.[nature and flavor] are sweet; Micro-puckery; Flat.[return through] spleen; Lung; Kidney channel.[function cures mainly] invigorating the spleen to arrest diarrhea; Lung benefiting nourishing kidney; Removing toxic substances sore.Main diarrhea due to hypofunction of the spleen; Emission due to deficiency of the kidney; Leukorrhagia; Frequent micturition; Cough due to consumptive disease; Quench one's thirst; Skin infection festers; Scald.[each discussion] " register planted by Guangxi medicine ": spleen reinforcing lung, arresting seminal emission gas, detumescence, pain relieving.[extracts] " China's book on Chinese herbal medicine "
Fructus Tribuli: [another name] thatch, Fructus Tribuli, Fructus Tribuli, drought grass, triangle Fructus Tribuli, three Fructus Gleditsia acupuncture, anise thorn, puncture frame, wild Pedicellus et Pericarpium Trapae, Pedicellus et Pericarpium Trapae.[source] medical material Ji Yuan: be the fruit of zygophyllaceae plant Fructus Tribuli and Flos Caryophylli disease Herba chenopodii.[nature and flavor] bitter in the mouth; Pungent; Property is put down.[return through] liver; Lung; Kidney; Heart channel.[function cures mainly] suppressing the hyperactive liver; Resolving depression; Dispelling pathogenic wind for improving eyesight.Main headache; Dizzy; Distending pain in the chest and hypochondrium; Distending pain of the breast; Breast closes obstructed; Amenorrhea; Cataract; Rubella pruritus; Vitiligo; Skin ulcer cellulitis; Scrofula.[each discussion] 1. " book on Chinese herbal medicine is just read ": Fructus Atriplicis Sibiricae, and benefaction is kind broken, specially enters lung, liver, lung qi dispersing stagnant, the soothing the liver stasis of blood, therefore can control migratory arthralgia order disease, and acute mastitis such as to gather at the disease.The product that temperature toil is loose, to dispel by for use, without tonic merit also.2. " about can cure mirror ": eliminating the pathogens from the lung gas and loose liver-wind, except conjunctivitis, lung abscess, breast carcinoma, eczema.3. " book on Chinese herbal medicine is new again ": town liver-wind, removing fire from the liver, QI invigorating is reduced phlegm, wet dissipation removing blood stasis, eliminating carbuncle cellulitis, sore-toxin dispersing.[extracts] " China's book on Chinese herbal medicine "
Herba arenariae kansuensis: [source] medical material Ji Yuan: be the herb of pinkwort Gansu sandwort.[nature and flavor] are sweet; Bitter; Cold in nature.[return through] liver; Gallbladder; Kidney channel.[function cures mainly] clearing and antitussive; Dampness removing jaundice eliminating; Exempt from numbness pain relieving.Main fever caused by exogenous pathogens; Cough due to lung-heat; Jaundice; Stranguria with turbid discharge; Rheumatic arthralgia; Hypertension.[extracts] " China's book on Chinese herbal medicine "
Radix Patriniae heterophyllae: [another name] Herba Astragali Sinici, tomb head ash, arrow wind, nine-headed bird, wind catching arrow, sweaty foot grass, Tong Ban road, Dens Tigris grass, malaria is careless, wood returns, from heel.[source] medical material Ji Yuan: be the root of Valerianaceae plant Radix Patriniae Scabrae or a little beans of different leaf.[nature and flavor] bitter in the mouth; Micro-sour and astringent; Cool in nature.[return through] GUIXIN; Liver Channel.[function cures mainly] dampness leukorrhagia stopping; Astringing to arrest bleeding; Heat-clearing and toxic substances removing.Main leucorrhea with red and white discharge; Metrorrhagia; Dysentery; Jaundice; Malaria; Intestinal carbuncle; Sore swollen toxin; Traumatic injury; Cervical cancer; Gastric cancer.[each discussion] " Guangxi Chinese medicinal herbal ": blood stasis dispelling, detumescence.Control traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Herba Jasmini laurifolii: [another name] large Caulis et Radix Periplocae Forrestii.[source] medical material Ji Yuan: be the Herb of Oleaceae plants branch and leaf Qin Xin.[nature and flavor] are bitter; Cold in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Dissipating blood stasis for subsidence of swelling.Main dysentery; Pyretic stranguria; Edema; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Herba Arthraxonis Hispidi: [another name] Lu bamboo, king's hay, crime grass, Dendrobium denneanum Kerr., straw mat, sparrow hawk foot Sha, Unreasoning grass, Jin Zhuo, straw mat grass, spire show bamboo, horse Auricled Hedyotis Herb, horse ear grass.[source] medical material Ji Yuan: be the herb of grass Herba Arthraxonis Hispidi.[nature and flavor] are bitter; Flat.[function cures mainly] relieving cough and relieving asthma; Parasite killing detoxifies.Main chronic cough asthma; Hepatitis; Pharyngolaryngitis; Stomatitis; Rhinitis; Lymphadenitis; Mastitis; Skin infection scabies.[each discussion] 1. " herbal classic ": main chronic cough dyspnea due to adverse flow of lung-QI is inverse, trembles with fear for a long time, and palpitation with fear, crusted scabies, white bald infections gas, kills skin small worm.2. " Jilin Chinese herbal medicine ": Dingchuan of dispeling cold.[extracts] " China's book on Chinese herbal medicine "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Mulberry 30 ~ 40 parts, Rhizoma Dispori Calcarati 15 ~ 30 parts, Herba Cynanchi Thesioidis 20 ~ 30 parts, Herba rhynchosiae volubilis 15 ~ 25 parts, the Fructus Sophorae 10 ~ 20 parts, Rhizoma Gymnadeniae 5 ~ 15 parts, Rhizoma Dioscoreae Alatae 15 ~ 30 parts, Fructus Tribuli 20 ~ 30 parts, Herba arenariae kansuensis 20 ~ 35 parts, Radix Patriniae heterophyllae 10 ~ 20 parts, Herba Jasmini laurifolii 15 ~ 25 parts and Herba Arthraxonis Hispidi 20 ~ 30 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Mulberry 30 ~ 35 parts, Rhizoma Dispori Calcarati 20 ~ 25 parts, Herba Cynanchi Thesioidis 25 ~ 30 parts, Herba rhynchosiae volubilis 15 ~ 20 parts, the Fructus Sophorae 10 ~ 15 parts, Rhizoma Gymnadeniae 5 ~ 10 parts, Rhizoma Dioscoreae Alatae 20 ~ 25 parts, Fructus Tribuli 25 ~ 30 parts, Herba arenariae kansuensis 20 ~ 25 parts, Radix Patriniae heterophyllae 10 ~ 15 parts, Herba Jasmini laurifolii 20 ~ 25 parts and Herba Arthraxonis Hispidi 25 ~ 30 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Mulberry 32 parts, Rhizoma Dispori Calcarati 25 parts, Herba Cynanchi Thesioidis 26 parts, Herba rhynchosiae volubilis 19 parts, the Fructus Sophorae 12 parts, Rhizoma Gymnadeniae 10 parts, Rhizoma Dioscoreae Alatae 22 parts, Fructus Tribuli 29 parts, Herba arenariae kansuensis 21 parts, Radix Patriniae heterophyllae 15 parts, Herba Jasmini laurifolii 21 parts and Herba Arthraxonis Hispidi 28 parts.
When the dosage form of described Chinese medicine preparation is granule, it comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
When the dosage form of described Chinese medicine preparation is capsule, it comprises the following steps:
The first step, Mulberry, Rhizoma Dispori Calcarati, Herba Cynanchi Thesioidis and Herba rhynchosiae volubilis are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Herba arenariae kansuensis, Radix Patriniae heterophyllae, Herba Jasmini laurifolii and Herba Arthraxonis Hispidi are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1: granule prepared by the present invention
Get Mulberry 320g, Rhizoma Dispori Calcarati 250g, Herba Cynanchi Thesioidis 260g, Herba rhynchosiae volubilis 190g, Fructus Sophorae 120g, Rhizoma Gymnadeniae 100g, Rhizoma Dioscoreae Alatae 220g, Fructus Tribuli 290g, Herba arenariae kansuensis 210g, Radix Patriniae heterophyllae 150g, Herba Jasmini laurifolii 210g and Herba Arthraxonis Hispidi 280g.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 85%, be heated to boiling reflux 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.05, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.36 times and 0.15 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.
Embodiment 2: capsule prepared by the present invention
Get Mulberry 350g, Rhizoma Dispori Calcarati 220g, Herba Cynanchi Thesioidis 290g, Herba rhynchosiae volubilis 160g, Fructus Sophorae 150g, Rhizoma Gymnadeniae 70g, Rhizoma Dioscoreae Alatae 250g, Fructus Tribuli 260g, Herba arenariae kansuensis 250g, Radix Patriniae heterophyllae 120g, Herba Jasmini laurifolii 250g and Herba Arthraxonis Hispidi 260g.
Its preparation method comprises the following steps:
The first step, Mulberry, Rhizoma Dispori Calcarati, Herba Cynanchi Thesioidis and Herba rhynchosiae volubilis are mixed in described ratio, add the water extraction volatile oil relative to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 80 minutes, temperature 40 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.16;
Second step, mixes Herba arenariae kansuensis, Radix Patriniae heterophyllae, Herba Jasmini laurifolii and Herba Arthraxonis Hispidi in described ratio, add relative to mixture 6 times amount determining alcohol be 85% alcohol reflux 4 times, each 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times of water gagings, boil 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 65 DEG C of reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 6 weight portion carboxymethyl starch sodium, 30 weight starch mix homogeneously, adding 160 weight portion determining alcohols is 85% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 4 weight portion magnesium stearate, then load in gelatine capsule.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 25-35g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 8.93g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 44.65 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>44.65 crude drug/kg of the present invention, every day, maximum dosage-feeding was 89.3 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.46g crude drug/day/people, adult body weight in 60KG, average dosage is 0.141g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 30g) oral administration gavage Chinese medicine of the present invention is 633 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 granule of the present invention to three groups of mices (often organize 20) by 13.27,25.45 and 42.38g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: all 150 routine cases all derive from this Out-patient Department and inpatient, and all patients are divided into treatment group and matched group at random.Wherein, treatment group 75 example, man 40 example, female 35 example; Age 21-65 year; Course of disease 1-12; Just control patient 45 example, control patient 30 example again.Matched group 75 example, man 39 example, female 36 example; Age 22-67 year; Course of disease 1-13; Just control patient 43 example, control patient 32 example again.Treatment group and matched group no significant difference in age, sex, the course of disease and clinical symptoms, has comparability.
Diagnostic criteria: formulate according to " Chinese medical disease Standardization of diagnosis and curative effect ".1, the initial stage only feels tired weak, dry cough, inappetence, and body is become thin gradually, and sick severe one can occur coughing (coughing up) blood, hectic fever, flushed cheeks, night sweat, and body such as obviously to be become thin the disease.2, often have and pulmonary tuberculosis person's close contact history.3, lesions position diminished breath sound, or hear and bronchial breathing sound and moist rale.4, sputum smear, concentrated or cultivation, tulase is positive more.5, erythrocyte sedimentation rate speeds.6, tuberculin skin test is strong positive.7, the visible tuberculose focus of XXian Shepianshi pulmonary.Sheet can be taken the photograph if desired as x-ray tomography.
Therapeutic Method:
Matched group: according to the formulation such as " Chinese tuberculosis control program implementation guide (version in 2008) ", " clinic diagnosis guide: tuberculosis fascicle " and " resistant tuberculosis chemotherapy guide (version in 2010) ".Initial treatment regimen is: 2H
3r
3z
3e
3/ 4H
3r
3(H: isoniazid, R: rifampicin, Z: pyrazinamide, E: ethambutol).The strengthening phase uses HRZE Regimen Chemotherapy 2 months, and the phase of continuing uses HR Regimen Chemotherapy 4 months.6 months courses for the treatment of.Retreatment regimen is: 2H
3r
3z
3e
3s
3/ 6H
3r
3e
3(H: isoniazid, R: rifampicin, Z: pyrazinamide, E: ethambutol, S: streptomycin).The strengthening phase uses SHRZE Regimen Chemotherapy 2 months, and the phase of continuing uses HRE Regimen Chemotherapy 6 months; 8 months courses for the treatment of.
Treatment group: on treatment of control group basis, simultaneously oral Chinese medicine embodiment 1 granule of the present invention, each 30g, every day 3 times; Just control patient treatment 6 months, copy patient treatment 8 months.
Curative effect judging standard: effective: after treatment, tuberculosis symptoms disappears, pulmonary tuberculosis cavity reduces 1/2 or more, and pulmonary lesions absorbs calcification completely, and Sputum inspection is turned out cloudy.Effective: the symptoms such as treatment rear pulmonary tuberculosis cough, spitting of blood have to be improved significantly, and cavity reduces 1/3-1/2, and pulmonary lesions is largely absorbed.Invalid: even phthisical symptom, sign are not any change deterioration after treatment, pulmonary tuberculosis focus is without any absorption, and any change does not occur empty size.
Therapeutic outcome: two groups treat respectively after, statistical result is see table 1.
Table 1 liang group is the rear Clinical efficacy comparison for the treatment of (unit: example) respectively
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 75 | 53 | 18 | 4 | 71(94.67％) |
| Matched group | 75 | 25 | 36 | 14 | 61(81.33％) |
As can be seen from Table 1, treatment group adopts Chinese medicine of the present invention, coordinates western medical treatment pulmonary tuberculosis, relative to matched group, on therapeutic effect, has significant improvement.
Concrete case: Zhao, female, 52 years old, suffers from pulmonary tuberculosis medical history and has a surplus for 8 years, patient because of heating, uncomfortable in chest, cough, bloody sputum diagnosis and treatment of being admitted to hospital in a week.Low grade fever, in the afternoon body temperature is had to increase, cough the bimester of near.Admission examination: T:38.5 DEG C; P:88 beat/min; R:28 beat/min, growth normal nutrition is slightly poor, sanity of becoming thin.Have a medical check-up breast examination bottom right lung percussion sore throat relieving, lower-left lung percussion sore throat relieving, sound auscultation bottom right pulmonary respiration sound weakens.The visible two lung unity and coherence in writing of o n plain chest films inspection increases thick, and right lung point has lamellar shade, and clinical diagnosis is pulmonary tuberculosis.Adopt retreatment regimen 2H
3r
3z
3e
3s
3/ 6H
3r
3e
3,the granule of oral inventive embodiments 1 simultaneously, each 30g, every day 3 times, medication 6 months, after treatment, tuberculosis symptoms disappears, and pulmonary tuberculosis cavity reduces more than 1/2, and pulmonary lesions absorbs calcification completely, and Sputum inspection is turned out cloudy, effective, follows up a case by regular visits to 1 year without recurrence.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. treat a phthisical Chinese medicine preparation, it is characterized in that, described Chinese medicine preparation comprises following raw medicinal material: Mulberry, Rhizoma Dispori Calcarati, Herba Cynanchi Thesioidis, Herba rhynchosiae volubilis, the Fructus Sophorae, Rhizoma Gymnadeniae, Rhizoma Dioscoreae Alatae, Fructus Tribuli, Herba arenariae kansuensis, Radix Patriniae heterophyllae, Herba Jasmini laurifolii and Herba Arthraxonis Hispidi.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Mulberry 30 ~ 40 parts, Rhizoma Dispori Calcarati 15 ~ 30 parts, Herba Cynanchi Thesioidis 20 ~ 30 parts, Herba rhynchosiae volubilis 15 ~ 25 parts, the Fructus Sophorae 10 ~ 20 parts, Rhizoma Gymnadeniae 5 ~ 15 parts, Rhizoma Dioscoreae Alatae 15 ~ 30 parts, Fructus Tribuli 20 ~ 30 parts, Herba arenariae kansuensis 20 ~ 35 parts, Radix Patriniae heterophyllae 10 ~ 20 parts, Herba Jasmini laurifolii 15 ~ 25 parts and Herba Arthraxonis Hispidi 20 ~ 30 parts.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Mulberry 30 ~ 35 parts, Rhizoma Dispori Calcarati 20 ~ 25 parts, Herba Cynanchi Thesioidis 25 ~ 30 parts, Herba rhynchosiae volubilis 15 ~ 20 parts, the Fructus Sophorae 10 ~ 15 parts, Rhizoma Gymnadeniae 5 ~ 10 parts, Rhizoma Dioscoreae Alatae 20 ~ 25 parts, Fructus Tribuli 25 ~ 30 parts, Herba arenariae kansuensis 20 ~ 25 parts, Radix Patriniae heterophyllae 10 ~ 15 parts, Herba Jasmini laurifolii 20 ~ 25 parts and Herba Arthraxonis Hispidi 25 ~ 30 parts.
4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Mulberry 32 parts, Rhizoma Dispori Calcarati 25 parts, Herba Cynanchi Thesioidis 26 parts, Herba rhynchosiae volubilis 19 parts, the Fructus Sophorae 12 parts, Rhizoma Gymnadeniae 10 parts, Rhizoma Dioscoreae Alatae 22 parts, Fructus Tribuli 29 parts, Herba arenariae kansuensis 21 parts, Radix Patriniae heterophyllae 15 parts, Herba Jasmini laurifolii 21 parts and Herba Arthraxonis Hispidi 28 parts.
5. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
6. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, Mulberry, Rhizoma Dispori Calcarati, Herba Cynanchi Thesioidis and Herba rhynchosiae volubilis are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Herba arenariae kansuensis, Radix Patriniae heterophyllae, Herba Jasmini laurifolii and Herba Arthraxonis Hispidi are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
7. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is granule, and it comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
8. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, Mulberry, Rhizoma Dispori Calcarati, Herba Cynanchi Thesioidis and Herba rhynchosiae volubilis are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Herba arenariae kansuensis, Radix Patriniae heterophyllae, Herba Jasmini laurifolii and Herba Arthraxonis Hispidi are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
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| CN105796955A (en) * | 2016-03-26 | 2016-07-27 | 王晓燕 | Traditional Chinese medicine for treating chronic purulent pleuritis and preparation method thereof |
| CN105998816A (en) * | 2016-06-30 | 2016-10-12 | 潜山县有余瓜蒌开发有限责任公司 | Trichosanthes kirilowii maxim stagnation-eliminating tablet traditional Chinese medicine composition for moistening lung and eliminating phlegm and preparation method thereof |
| CN106075111A (en) * | 2016-06-19 | 2016-11-09 | 王京涛 | One treats paronychial Chinese medicine preparation and preparation method thereof |
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| CN1228993A (en) * | 1999-02-03 | 1999-09-22 | 叶庆莲 | Traditional Chinese medicine for treating tuberculosis |
| CN104825960A (en) * | 2015-05-06 | 2015-08-12 | 陈洪芳 | Traditional Chinese medicine for treating pulmonary tuberculosis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1228993A (en) * | 1999-02-03 | 1999-09-22 | 叶庆莲 | Traditional Chinese medicine for treating tuberculosis |
| CN104825960A (en) * | 2015-05-06 | 2015-08-12 | 陈洪芳 | Traditional Chinese medicine for treating pulmonary tuberculosis and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796955A (en) * | 2016-03-26 | 2016-07-27 | 王晓燕 | Traditional Chinese medicine for treating chronic purulent pleuritis and preparation method thereof |
| CN106075111A (en) * | 2016-06-19 | 2016-11-09 | 王京涛 | One treats paronychial Chinese medicine preparation and preparation method thereof |
| CN105998816A (en) * | 2016-06-30 | 2016-10-12 | 潜山县有余瓜蒌开发有限责任公司 | Trichosanthes kirilowii maxim stagnation-eliminating tablet traditional Chinese medicine composition for moistening lung and eliminating phlegm and preparation method thereof |
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Application publication date: 20160309 |