CN104721685A - Chinese herba preparation capable of regulating gastrointestinal flora disequilibrium and preparation method of Chinese herba preparation - Google Patents
Chinese herba preparation capable of regulating gastrointestinal flora disequilibrium and preparation method of Chinese herba preparation Download PDFInfo
- Publication number
- CN104721685A CN104721685A CN201510168828.2A CN201510168828A CN104721685A CN 104721685 A CN104721685 A CN 104721685A CN 201510168828 A CN201510168828 A CN 201510168828A CN 104721685 A CN104721685 A CN 104721685A
- Authority
- CN
- China
- Prior art keywords
- radix
- poria
- levan
- gastrointestinal tract
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a Chinese herba preparation capable of regulating gastrointestinal flora disequilibrium and a preparation method of the Chinese herba preparation. The Chinese herba preparation comprises ginseng, elecampane, white poria, roasted rhizoma atractylodis macrocephalae, agastache leaves, roots of kudzu vine, herba lycopi, galangal, eupatorium, inulin, tuckahoe and the like. The Chinese herba preparation is safe and effective, has an obvious effect, and can promote multiplication of gastrointestinal bacteria obviously; and the gastrointestinal tract of a patient can be regulated further by the Chinese herba preparation.
Description
Technical field
The present invention relates to the field of Chinese medicines, be related specifically to a kind of Chinese medicine preparation regulating Biology Barrier of Gastrointestinal Tract to lack of proper care and preparation method thereof.
Background technology
Live away from home in the gastrointestinal tract of Healthy People miscellaneous microorganism, these microorganisms are called intestinal microbial population.Intestinal microbial population combines according to a certain percentage, condition each other between each bacterium, depend on each other for existence, quality and quantity is formed a kind of ecological balance, once body internal and external environment changes, particularly prolonged application broad ectrum antibiotic, responsive Enterobacter cloaca is suppressed, not repressed antibacterial and seize the opportunity breeding, thus causes dysbacteriosis, the combination of its normal physiological is destroyed, and produces pathologic combination, causes clinical symptoms to be just called alteration of intestinal flora disease.
Dysbacteriosis reason have some:
1. dietary factor
Diet can make faecal flora occur obviously to change.Bacterial translocation is promoted without fiber food.Fiber can maintain homergy and the cyto-dynamics of protection of intestinal mucosal barrier cells.Dietary fiber can reduce bacterial translocation, but barrier function can not be made to return to normally.
2. the changing factor of flora
Flora composition can there are differences because individual different, but concerning same person, within quite long period, flora composition is very stable.The ecological status of each strain determined by the impact of the interaction between the physiological status of host, antibacterial and environment.
3. the metabolic factor of medicine
Intestinal flora plays an important role in the metabolism of many medicines, comprises lactulose, sulfasalazine, levodopa etc.Any antibiotic all can cause the change of Intestinal flora, and it depends on the antimicrobial spectrum of medicine and the concentration in enteric cavity thereof.Clindamycin and ampicillin etc. easily cause dysbacteriosis, make the clostridium difficile amount reproduction of drug resistance and cause a disease, causing antibiotic-associated diarrhea (pseudomembranous enteritis).The H2-receptor antagonists such as application cimetidine can cause the low gastric acid of Drug and gastric bacterial multiplication.
4. age factor
Along with increasing of age, the balance of intestinal microbial population can change, and bacillus bifidus reduces, and bacillus perfringens increases, and the former likely weakens the stimulation to immune function, and the latter causes toxin increase that immunity is suppressed.Perhaps, old people, if intestinal microbial population when maintaining young balances, can improve immunocompetence.
5. gastrointestinal tract immune dysfunction
Gastrointestinal tract normal immunological function is from the plasma cell of mucosa lamina propria, and plasma cell can produce a large amount of immunoglobulins, i.e. secretory IgA, this main matter preventing antibacterial from invading for gastrointestinal tract.Once gastrointestinal tract mucosa synthon or binary IgA, or synthesis secretion sheet function generation obstacle, cause in gastro-intestinal secretion liquid and lack typing IgA, then can cause aerobe and anaerobe excessive multiplication in small intestinal, thus cause dysbacteriosis, cause chronic diarrhea.Asymptomatic IgA deficient patients, little intestinal flora also can excessive multiplication.Neonatal period dysbacteriosis incidence rate is higher, also may be relevant with developing immune system immaturity or imperfection.
During dysbacteriosis, cause superinfection or superinfection (superinfection) more, namely in the treatment of primary infection, there occurs the infection of another kind of new pathogenic bacterium.Being more common in of dysbacteriosis uses antibiotic and Chronic consumptions etc.After widely applying broad ectrum antibiotic for a long time clinically, most of sensitive organism and normal flora suppressed or kill, but fastbacteria then obtains survival advantage and amount reproduction causes a disease, as resistant Staphylococcus aureus causes diarrhoea, septicemia, thrush, vaginitis, intestinal and anal infection are caused to the insensitive candida albicans bacterium of antibiotic.
Summary of the invention
The object of the invention is to solve the deficiencies in the prior art, a kind of Chinese medicine preparation regulating Biology Barrier of Gastrointestinal Tract to lack of proper care and preparation method thereof is provided.
For achieving the above object, the technical solution used in the present invention is: be made up of following weight item: levan 1-20g, Radix Ginseng 1-10g, Radix Aucklandiae 1-20g, Poria 1-20g, Rhizoma Atractylodis Macrocephalae (parched) 1-20g, Radix agastaches 1-20g, Radix Puerariae 1-20g, Radix Glycyrrhizae 1-20g, Herba Lycopi 1-20g, Rhizoma Alpiniae Officinarum 1-20g, Herba Eupatorii 1-20g, mountain quarrel 1-20g, Fructus Jujubae 1-20g, inulin 1-20g, Poria 1-20g, spirulina 1-20g.
Further, the present invention has following weight composition: levan 1-15g, Radix Ginseng 1-8g, Radix Aucklandiae 1-15g, Poria 1-15g, Rhizoma Atractylodis Macrocephalae (parched) 1-10g, Radix agastaches 1-10g, Radix Puerariae 1-15g, Radix Glycyrrhizae 1-20g, Herba Lycopi 1-10g, Rhizoma Alpiniae Officinarum 1-10g, Herba Eupatorii 1-8g, mountain quarrel 1-20g, Fructus Jujubae 1-20g, inulin 1-5g, Poria 1-15g, spirulina 1-15g.
Further, the present invention has following weight composition: levan 10g, Radix Ginseng 3g, Radix Aucklandiae 6g, Poria 8g, Rhizoma Atractylodis Macrocephalae (parched) 6g, Radix agastaches 6g, Radix Puerariae 11g, Radix Glycyrrhizae 15g, Herba Lycopi 6, Rhizoma Alpiniae Officinarum 6g, Herba Eupatorii 5g, mountain quarrel 15g, Fructus Jujubae 15g, inulin 3g, Poria 4g, spirulina 10g.
Further, the present invention also comprises adjuvant and additive.
Further, the present invention is any one in oral liquid, tablet, capsule, powder.
Further, levan of the present invention comprises the following steps: get dry Zhejiang Tubers of Ophiopogon japonicus or river Tubers of Ophiopogon japonicus, and with 3 times of weight 90% alcohol reflux 2 times, extracting solution abandons it; Medicinal residues 10 times amount water extraction 2 times, merge Aqueous extracts, Aqueous extracts is evaporated to 1.0g/ml; Water extracting liquid adds 2 times of volume 95% alcohol settling, leaves standstill, and centrifugal segregation precipitates; Supernatant adds 3 times of volume 95% alcohol settling again, hold over night, collects the precipitation of gained, dry, levan extract namely.
Further, preparation process of the present invention has the following steps: Radix Ginseng, the Radix Aucklandiae, Poria, Rhizoma Atractylodis Macrocephalae (parched), Radix agastaches, Radix Puerariae, Herba Lycopi, Rhizoma Alpiniae Officinarum, Herba Eupatorii, inulin, Poria take according to aforementioned proportion by (1), pours the water of 1-10 times amount into, decoct 2-5 hour, filter, collect filtrate, medicinal residues are collected, again pour 1-3 water doubly into, decoct 1-3 hour, collecting by filtration filtrate, merges twice filtrate, vacuum decompression distills to obtain mastic, and drying and crushing obtains powder; (2) by levan, Radix Glycyrrhizae, Fructus Crataegi, Fructus Jujubae, spirulina proportionally, be placed in pulverizer and pulverize, cross 200 mesh standard sieves and obtain mixed-powder; (3) step (1) gained powder and step (2) gained powder are stirred 2 hours, mixing; (4) step (3) gained is added suitable adjuvant, be prepared into corresponding dosage form.
The present invention adopts levan as raw material, levan can promote the propagation of probiotics in intestinal (as lactobacillus, bacillus bifidus etc.), suppress the growth reducing pathogen and putrefaction bacteria (as escherichia coli etc.) simultaneously, recover intestinal environment, improve the effect of intestinal microbial population.The present invention adopts Radix Ginseng, the Radix Aucklandiae, Poria, Rhizoma Atractylodis Macrocephalae (parched), Radix agastaches, Radix Puerariae, Herba Lycopi, Rhizoma Alpiniae Officinarum, Herba Eupatorii, inulin, Poria, Radix Glycyrrhizae, Fructus Crataegi, Fructus Jujubae, provide a kind of Chinese medicine preparation of the flora of regulating intestinal canal safely and effectively, more safe and effective, medical material is extensive, safety non-pollution.The present invention adopts spirulina to be raw material further, eight seed amino acids being rich in needed by human and can not synthesizing voluntarily, in blood fat reducing, anticancer, defying age, radioprotective, hepatoprotective, raising immunity of organisms and hemopoietic function, regulate in metabolism etc. all there is good effects, spirulina has prebiotic function, obviously can promote the propagation of intestinal lactobacillus and bacillus bifidus, further recuperating gastrointestinal tract.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with specific embodiment, the present invention is further elaborated.
Levan of the present invention (fructan) is that the ubiquitous class of occurring in nature is mainly with the carbohydrate general name that fructosyl fructose is formed by connecting for glycosidic bond; All contain 1 molecule glucose in each levan molecule, its molecular end does not have reproducibility.According to the difference of the degree of polymerization between the fructosyl transfer difference of link position and species, levan structure is quite complicated.Due to levan substantially do not decompose in the process of human oral cavity, stomach and small intestinal, not digested absorption.Effectively can promote the propagation of probiotics in intestinal (as lactobacillus, bacillus bifidus etc.), suppress the growth reducing pathogen and putrefaction bacteria (as escherichia coli etc.) simultaneously, recover intestinal environment.Above result shows, levan extract tool of the present invention is significantly improved the effect of intestinal microbial population.
Radix Ginseng nature and flavor of the present invention, sweet in the mouth, micro-hardship, warm in nature, flat.Return spleen, lung meridian, heart channel.QI invigorating, Gu de-, promote the production of body fluid, calms the nerves, Fructus Alpiniae Oxyphyllae.Nature and flavor: sweet in the mouth, micro-hardship are warm in nature, flat.Return spleen, lung meridian, heart channel.QI invigorating, Gu de-, promote the production of body fluid, calms the nerves, Fructus Alpiniae Oxyphyllae.Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.Cure mainly: weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and the shock caused after losing blood, collapse.Strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves.Control impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, and frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies.
The Radix Aucklandiae of the present invention, Chinese medicine name.For the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne..Autumn, season in winter two excavate, and removing silt and fibrous root, cutting, large vertical profile again becomes lobe, hits rough bark after drying.Nature and flavor, pungent, bitter, temperature.Gui Jing, returns spleen, stomach, large intestine, three burnt, gallbladder meridians.Effect, promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Cure mainly, for the breast side of body, abdominal distention, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.
Poria, meridian distribution of property and flavor, sweet; Light; Flat.The heart; Spleen; Lung; Kidney channel.Eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.For dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine.For diarrhea due to hypofunction of the spleen, Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as Poria normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Poria can be used as again tonifying the lung spleen, controls the adjuvant of the deficiency of vital energy.For cardiopalmus, insomnia waits disease Poria energy tranquilizing by nourishing the heart, therefore can be used for the diseases such as irritability, cardiopalmus, insomnia, the compatibilities such as Poria normal and Radix Ginseng, Radix Polygalae, Semen Ziziphi Spinosae.For cough due to fluid-retention, phlegm-damp enters network, and aching pain in should and back Poria can promoting diuresis to eliminate damp pathogen, has again a function of invigorating spleen, for insufficiency of the spleen can not transmitting and distributing the fluids, stop the disease of the raw phlegm retention of dimerization, there is therapeutical effect.
Rhizoma Atractylodis Macrocephalae (parched) has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." medicine origin " is recorded: " dehumidifying benefit is dry, and middle QI invigorating, warming middle-JIAO, go in taste wet, except gastric heat, strong taste, enter diet, quench the thirst, antiabortive.”
Radix agastaches: removing dampness spleen, regulating qi-flowing for harmonizing stomach: for dampness taste, distension and fullness in the abdomen, hygropyrexia from the beginning of.If retention of dampness in middle-JIAO, oppression sensation over the epigastrium and anorexia person, be equal to Herba Eupatorii and use; If hygropyrexia from the beginning of, Herba Menthae, Herba Artemisiae Scopariae can be joined, Radix Scutellariae is equivalent uses.Preventing or arresting vomiting antidiarrheal: for vomitting, having loose bowels.If experience foul, vomit the disease had loose bowels, Folium Perillae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis can be joined, Pericarpium Citri Reticulatae is equivalent uses; If gastrofrigid vomiting person, the Rhizoma Pinelliae can be joined with using; As damp and hot person, Rhizoma Coptidis, Caulis Bambusae In Taenia can be joined; Weakness of the spleen and stomach person, can join Radix Codonopsis, Radix Glycyrrhizae; Vomiting during pregnancy, can join Fructus Amomi with using.Drive away summer heat: for heat-damp in summer disease.It controls heat-damp in summer, no matter partially cold, partial heat, all can apply, and clinically often uses together with Herba Eupatorii compatibility.Relieving the exterior syndrome by diaphoresis: for fever with chills, fever with aversion to cold, chest distress.Compatibility Folium Perillae, Pericarpium Citri Reticulatae.Improving eyesight: the growth of vitamin A to eyes has very important effect, synthesis retina rod cell photoactive substance.Improve resistance against diseases and the prevention nyctalopia of eyes.Other effects: control nasal sinusitis, often can join the equivalent use of Fel Sus domestica.
Radix Puerariae: nature and flavor, sweet in the mouth, pungent, cool in nature.Gui Jing attaches to the lung and stomach meridians.Effect, expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.Cure mainly for exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.
Radix Glycyrrhizae: sweet in the mouth, gas is put down, and property is delayed.Enter spleen of Foot-Taiyin, the stomach channel of foot-Yang-ming.Standby punching and positive taste, grasp pure and honest good money, Ru Jin Mu Liangjiazhi circle, return between extreme misery two gas, cultivate Central Region, bring up four other, the panacea of sexual intercourse spirit, tune helps the miracle of QI and blood.
Herba Lycopi is the dry aerial parts of labiate hair leaf lycopus lucidus Lycopus lucidus Turcz.vat.hirtus Regel.Summer, autumn two tap when season, stem and leaf was luxuriant, dry.Be distributed in China's most area.There is promoting blood flow to regulate menstruation, blood stasis dispelling eliminating carbuncle, effect of inducing diuresis to remove edema.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, sore and toxic, edema ascites.
Rhizoma Alpiniae Officinarum: nature and flavor acrid in the mouth, hot in nature.Gui Jing returns spleen, stomach warp.Effect stomach warming preventing or arresting vomiting, dispersing cold for relieving pain.Cure mainly for coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.
Herba Eupatorii: nature and flavor, acrid in the mouth, property is put down.Return through spleen, stomach, lung meridian.Function has removing dampness by means of aromatics, and appetizing of being amusing, delivers the effect of expelling summer-heat.Cure mainly for turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer exterior syndrome, hygropyrexia from the beginning of, heating asthenia, does not uncomfortable in chestly relax.
Mountain quarrel is used for helping digestion long-pending, dissipating blood stasis blood, expelling tenia.Control meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia after-pains in puerperal, lochiorrhea, children's's breast food is stagnated.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, stomach alkane distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipidemia.
Fructus Jujubae: can muscle strength reinforcing, allaying tiredness, blood vessel dilating, increase myocardial contraction, improve myocardial nutrition, to control cardiovascular system diseases have good effect; Chinese medicine theory is thought, Fructus Jujubae has the effects such as tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach, and Fructus Jujubae has good therapeutic effect to diseases such as chronic hepatitis, liver cirrhosis, anemia, anaphylactoid purpura; Fructus Jujubae contains triterpenoid compound and cyclic adenosine monophosphate, has stronger anticancer, anti-allergic effects.Fructus Jujubae can moisten cardiopulmonary, cough-relieving, tonifying five ZANG-organs, it is deficient to control, except the intestines and stomach addiction gas, can also regulating the spleen and stomach support spleen, flat gastric qi, logical nine orifices, help 12 through etc.
Inulin: have bacillus bifidus effect in propagation human body, thus can suppress the growth of enteral Salmonella and putrefaction bacteria, promotes outside intestinal peristalsis promoting, prevents treating constipation, regulates gastrointestinal function; Be conducive to vitamin synthesis, promote mineral absorption, significantly improve antibody, proliferative cell and raising NK cytoactive, strengthen immunologic function, improve the effect of immunity; Waste-discharging and youth-keeping function.The symptoms such as the harmful substance in human body mainly contains: the dunghills such as ammonia, hydrogen sulfide, amine, phenol, and these poisonous substances not only cause halitosis, words fester, skin lacks flexibility, hair dries up, constipation diarrhoea, face give birth to pox, weak and sickly.Take inulin and can get rid of vivotoxin, alleviate the internal organs such as liver, kidney burden.Inulin works in coordination with bacillus bifidus effect, forms rectum defecation reflex, plays toxin expelling effect.Safe and effective, without any side effects; Distinctive dietary fiber can improve lipid metabolism, reduces blood high-density lipoprotein, improves low density lipoprotein, LDL, indirectly reduces blood fat, cholesterol and fat.Inulin is not easily absorbed by the body, can not by sugar--lipid metabolism approach synthctic fat, thus reach slimming effect; Help to control blood glucose, blood sugar lowering (Europe is mainly taken as diabetes patient's treatment); For coordinating insulinize, can not glycemic index be increased, be suitable for diabetes patient; Prevent dental caries.Inulin not easily makes the coagulation of dental caries pathogen, and its lactic acid production formed on face of gear 23-50% lower than sucrose, dental caries rate is well below sucrose.
Poria: abnormal smells from the patient is light and ooze, its property is up, born fluid, loosing the interspaces of skin and muscles, grows water source and declines, diuresis, therefore Zhang Jiegu calls its genus sun, floats and rises, saying its property also; Dong Yuan calls it for the YIN aspect of YANG, fall and under, Yan Qigong is also.
Spirulina: there is defying age, anti-hypoxia, resisting fatigue, radioprotective, blood fat reducing, blood pressure lowering, nourishing the liver protect the effects such as stomach.Hyperalkaline food, abundant basic mineral (especially potassium and calcareous), can maintain the balance of pH-value in blood, reduce cholesterol, alleviating hypertension and cardiac symptom or reduce its incidence probability; Effectively improve gastric disease symptoms, resist various diarrhoea and constipation; Prevent and treat anemia, carotenoid content is 1.5 times of Radix Dauci Sativae, and vitamin B12 content is 4 times of Hepar Sus domestica, and iron content is 23 times of Herba Spinaciae; Containing the linolenic acid that human body self can not synthesize, help lipid metabolism, prevent thrombosis, effectively to resisting cardiovascular disease, prevention fatty liver and liver cirrhosis, reduce blood glucose, prevent diabetes.
Above drug synergism, the common effect playing recuperating gastrointestinal tract dysbacteriosis.
Embodiment 1
Concrete formula:
Levan 10g, Radix Ginseng 3g, Radix Aucklandiae 6g, Poria 8g, Rhizoma Atractylodis Macrocephalae (parched) 6g, Radix agastaches 6g, Radix Puerariae 11g, Radix Glycyrrhizae 15g, Herba Lycopi 6, Rhizoma Alpiniae Officinarum 6g, Herba Eupatorii 5g, mountain quarrel 15g, Fructus Jujubae 15g, inulin 3g, Poria 4g, spirulina 10g, powder adjuvant, essence.
Above-mentioned levan comprises the following steps: get dry Zhejiang Tubers of Ophiopogon japonicus, and with 3 times of weight 90% alcohol reflux 2 times, extracting solution abandons it; Medicinal residues 10 times amount water extraction 2 times, merge Aqueous extracts, Aqueous extracts is evaporated to 1.0g/ml; Water extracting liquid adds 2 times of volume 95% alcohol settling, leaves standstill, and centrifugal segregation precipitates; Supernatant adds 3 times of volume 95% alcohol settling again, hold over night, collects the precipitation of gained, dry, is the levan extract of molecular weight in 2000 ~ 10000 scopes.
The preparation process of above-mentioned Chinese medicine preparation has the following steps: Radix Ginseng, the Radix Aucklandiae, Poria, Rhizoma Atractylodis Macrocephalae (parched), Radix agastaches, Radix Puerariae, Herba Lycopi, Rhizoma Alpiniae Officinarum, Herba Eupatorii, inulin, Poria take according to aforementioned proportion by (1), pour the water of 5 times amount into, decoct 2 hours, filter, collect filtrate, medicinal residues are collected, again pours the water of 1 times into, decoct 2 hours, collecting by filtration filtrate, merge twice filtrate, vacuum decompression distills to obtain mastic, and drying and crushing obtains powder; (2) by levan, Radix Glycyrrhizae, Fructus Crataegi, Fructus Jujubae, spirulina proportionally, be placed in pulverizer and pulverize, cross 200 mesh standard sieves and obtain mixed-powder; (3) step (1) gained powder and step (2) gained powder are stirred 2 hours, mixing; (4) step (3) gained is added suitable amount of adhesive, soft material processed, dry, granulate, adds appropriate powder adjuvant and essence, and mix homogeneously obtains the Chinese medicine preparation of the adjustment Biology Barrier of Gastrointestinal Tract imbalance of powder preparation formulation.
Embodiment 2
Concrete formula:
The present invention has following weight composition: levan 15g, Radix Ginseng 5g, Radix Aucklandiae 3g, Poria 6g, Rhizoma Atractylodis Macrocephalae (parched) 3g, Radix agastaches 10g, Radix Puerariae 5g, Radix Glycyrrhizae 20g, Herba Lycopi 3, Rhizoma Alpiniae Officinarum 6g, Herba Eupatorii 3g, mountain quarrel 20g, Fructus Jujubae 20g, inulin 1g, Poria 3g, spirulina 15g.
Above-mentioned levan comprises the following steps: get dry Zhejiang Tubers of Ophiopogon japonicus or river Tubers of Ophiopogon japonicus, and with 3 times of weight 90% alcohol reflux 2 times, extracting solution abandons it; Medicinal residues 10 times amount water extraction 2 times, merge Aqueous extracts, Aqueous extracts is evaporated to 1.0g/ml; Water extracting liquid adds 2 times of volume 95% alcohol settling, leaves standstill, and centrifugal segregation precipitates; Supernatant adds 3 times of volume 95% alcohol settling again, hold over night, collects the precipitation of gained, dry, is the levan extract of molecular weight in 2000 ~ 10000 scopes.
Further, preparation process of the present invention has the following steps: Radix Ginseng, the Radix Aucklandiae, Poria, Rhizoma Atractylodis Macrocephalae (parched), Radix agastaches, Radix Puerariae, Herba Lycopi, Rhizoma Alpiniae Officinarum, Herba Eupatorii, inulin, Poria take according to aforementioned proportion by (1), pours the water of 5 times amount into, decoct 2 hours, filter, collect filtrate, medicinal residues are collected, again pour the water of 1 times into, decoct 3 hours, collecting by filtration filtrate, merges twice filtrate, vacuum decompression distills to obtain mastic, and drying and crushing obtains powder; (2) by levan, Radix Glycyrrhizae, Fructus Crataegi, Fructus Jujubae, spirulina proportionally, be placed in pulverizer and pulverize, cross 200 mesh standard sieves and obtain mixed-powder; (3) step (1) gained powder and step (2) gained powder are stirred 2 hours, mixing; (4) step (3) gained is added binding agent, soft material processed, granulate, dry, granulate, adds capsule adjuvant, and mixing, pours in capsule, be prepared into capsule.
Embodiment 3
Concrete formula:
The present invention has following weight composition: levan 5g, Radix Ginseng 3g, Radix Aucklandiae 8g, Poria 10g, Rhizoma Atractylodis Macrocephalae (parched) 5g, Radix agastaches 5g, Radix Puerariae 6g, Radix Glycyrrhizae 15g, Herba Lycopi 8, Rhizoma Alpiniae Officinarum 8g, Herba Eupatorii 3g, mountain quarrel 15g, Fructus Jujubae 18g, inulin 2g, Poria 4g, spirulina 14g.
Above-mentioned levan comprises the following steps: get dry Zhejiang Tubers of Ophiopogon japonicus or river Tubers of Ophiopogon japonicus, and with 3 times of weight 90% alcohol reflux 2 times, extracting solution abandons it: medicinal residues 10 times amount water extraction 2 times, merging Aqueous extracts, and Aqueous extracts is evaporated to 1.0g/ml; Water extracting liquid adds 2 times of volume 95% alcohol settling, leaves standstill, and centrifugal segregation precipitates; Supernatant adds 3 times of volume 95% alcohol settling again, hold over night, collects the precipitation of gained, dry, is the levan extract of molecular weight in 2000 ~ 10000 scopes.
Further, preparation process of the present invention has the following steps: Radix Ginseng, the Radix Aucklandiae, Poria, Rhizoma Atractylodis Macrocephalae (parched), Radix agastaches, Radix Puerariae, Herba Lycopi, Rhizoma Alpiniae Officinarum, Herba Eupatorii, inulin, Poria take according to aforementioned proportion by (1), pours the water of 5 times amount into, decoct 2 hours, filter, collect filtrate, medicinal residues are collected, again pour the water of 1 times into, decoct 3 hours, collecting by filtration filtrate, merges twice filtrate, vacuum decompression distills to obtain mastic, and drying and crushing obtains powder; (2) by levan, Radix Glycyrrhizae, Fructus Crataegi, Fructus Jujubae, spirulina proportionally, be placed in pulverizer and pulverize, cross 200 mesh standard sieves and obtain mixed-powder; (3) step (1) gained powder and step (2) gained powder are stirred 2 hours, mixing; (4) step (3) gained is added oral adjuvant and essence, the oral liquid of mixing.
Embodiment 4
1, test material:
Get the rat of 15 ~ 30g, male and female half and half,
Modeling medicine and dosage choice
Cefradine Capsules (Shandong Chen Xin pharmaceutcal corporation, Ltd) gentamicin injection liquid (Shaanxi Bi Kang pharmaceutical Co. Ltd), is made into physiological saline solution the antibiotic mixed liquor that concentration is 50gL.Normal group gives sterilized water 0.4mL/ (* time) gavage, all the other respectively group adopt antibiotic mixed liquor 0.4mL/ (* time) gavage.Every day 2 times, continuous 6d.
Total number of bacteria: beef-protein medium.
Escherichia coli: eosin methylene blue agar (EMB).
Lactobacillus: MRS agar culture medium.
Bacillus bifidus: BBL agar culture medium.
2, operational approach:
Rat is divided into 3 groups at random, i.e. the experimental group of the adjustment Biology Barrier of Gastrointestinal Tract imbalance of normal group, model group and 1 multiple dose, 10/group, male and female half and half.Normal group gives sterilized water and normal diet, and model group is to sterilized water and normal diet, and regulate the experimental group of Biology Barrier of Gastrointestinal Tract imbalance to carry out embodiment 3 gavage, give normal diet, normally raise, the gavage time is 1 week.
Intestinal samples: the neck that broken by the mice of gavage after 1 week is put to death, and carries out the content that aseptic collection respectively organizes caecum section, collects and is mixed by sterile working with group mouse intestinal content, for subsequent use.
Antibacterial culturing and counting: take a certain amount of intestinal contents and put into by organizing sterile working respectively the triangular flask that bead and sterilized water are housed, mixed bacterium method is adopted to carry out the colony counting of the educable aerobic and anaerobe of 3 class, each dilution factor does 3 repetitions, asks its meansigma methods and calculates the bacterium number contained by every gram of intestinal contents.
3, result
From rat appearance features, the drying of normal group rat fresh excreta is in yellow, and after modeling, rat fresh excreta color turns black by Huang, occurs mild diarrhea.After treatment, experimental group rat diarrhoea takes a turn for the better completely, and during modeling, model rat occurs lethargy, drowsiness, fears the phenomenons such as cold, and after treatment, each group mice is dispirited, drowsiness, fears the phenomenon such as cold and all take a favorable turn.Show the body weight monitoring of each group of mice, experimental group rat body weight increases obviously each faster than other group.
The count results of microbiological indicator is in table 1.As shown in Table 1, the number of the various flora of model group is all low than normal group, representing that antibiotic changes intestinal phase by killing part microorganism in intestinal, causing diarrhoea.Comparatively speaking, the coliform count of experimental group, total number of bacteria, lactobacillus number and bacillus bifidus number are close to normal group level, illustrate that Chinese medicine preparation of the present invention effectively can promote the growth of profitable strain in intestinal, reduce the breeding of pernicious bacteria, the curative effect of adjustment intestine microenvironment.
Although be described preferred embodiment of the present invention above; but the present invention is not limited to above-mentioned detailed description of the invention; above-mentioned detailed description of the invention is only schematic; be not restrictive; those of ordinary skill in the art is under enlightenment of the present invention; do not departing under the ambit that present inventive concept and claim protects, can also make a lot of form, these all belong within protection scope of the present invention.
Claims (7)
1. the Chinese medicine preparation regulating Biology Barrier of Gastrointestinal Tract to lack of proper care, is characterized in that: be made up of following parts by weight of component: levan 1-20g, Radix Ginseng 1-10g, Radix Aucklandiae 1-20g, Poria 1-20g, Rhizoma Atractylodis Macrocephalae (parched) 1-20g, Radix agastaches 1-20g, Radix Puerariae 1-20g, Radix Glycyrrhizae 1-20g, Herba Lycopi 1-20g, Rhizoma Alpiniae Officinarum 1-20g, Herba Eupatorii 1-20g, mountain quarrel 1-20g, Fructus Jujubae 1-20g, inulin 1-20g, Poria 1-20g, spirulina 1-20g.
2. a kind of Chinese medicine preparation regulating Biology Barrier of Gastrointestinal Tract to lack of proper care according to claim 1, is characterized in that: levan 1-15g, Radix Ginseng 1-8g, Radix Aucklandiae 1-15g, Poria 1-15g, Rhizoma Atractylodis Macrocephalae (parched) 1-10g, Radix agastaches 1-10g, Radix Puerariae 1-15g, Radix Glycyrrhizae 1-20g, Herba Lycopi 1-10g, Rhizoma Alpiniae Officinarum 1-10g, Herba Eupatorii 1-8g, mountain quarrel 1-20g, Fructus Jujubae 1-20g, inulin 1-5g, Poria 1-15g, spirulina 1-15g.
3. a kind of Chinese medicine preparation regulating Biology Barrier of Gastrointestinal Tract to lack of proper care according to claim 1 and 2, is characterized in that: levan 10g, Radix Ginseng 3g, Radix Aucklandiae 6g, Poria 8g, Rhizoma Atractylodis Macrocephalae (parched) 6g, Radix agastaches 6g, Radix Puerariae 11g, Radix Glycyrrhizae 15g, Herba Lycopi 6, Rhizoma Alpiniae Officinarum 6g, Herba Eupatorii 5g, mountain quarrel 15g, Fructus Jujubae 15g, inulin 3g, Poria 4g, spirulina 10g.
4. a kind of Chinese medicine preparation regulating Biology Barrier of Gastrointestinal Tract to lack of proper care according to claims 1 to 3, is characterized in that: also comprise adjuvant and additive.
5. a kind of Chinese medicine preparation regulating Biology Barrier of Gastrointestinal Tract to lack of proper care according to Claims 1-4, is characterized in that: be any one in oral liquid, tablet, capsule, powder.
6. according to a kind of Chinese medicine preparation regulating Biology Barrier of Gastrointestinal Tract to lack of proper care described in claim 1 to 5, it is characterized in that: described levan comprises the following steps: get dry Zhejiang Tubers of Ophiopogon japonicus or river Tubers of Ophiopogon japonicus, with 3 times of weight 90% alcohol reflux 2 times, extracting solution abandons it: medicinal residues 10 times amount water extraction 2 times, merge Aqueous extracts, Aqueous extracts is evaporated to 1.0g/ml; Water extracting liquid adds 2 times of volume 95% alcohol settling, leaves standstill, and centrifugal segregation precipitates; Supernatant adds 3 times of volume 95% alcohol settling again, hold over night, collects the precipitation of gained, dry, levan extract namely.
7. according to the preparation method of a kind of Chinese medicine preparation regulating Biology Barrier of Gastrointestinal Tract to lack of proper care described in claim 1 to 6, it is characterized in that: have the following steps: Radix Ginseng, the Radix Aucklandiae, Poria, Rhizoma Atractylodis Macrocephalae (parched), Radix agastaches, Radix Puerariae, Herba Lycopi, Rhizoma Alpiniae Officinarum, Herba Eupatorii, inulin, Poria take according to aforementioned proportion by (1), pour the water of 1-10 times amount into, decoct 2-5 hour, filter, collect filtrate, medicinal residues are collected, again pour 1-3 water doubly into, decoct 1-3 hour, collecting by filtration filtrate, merges twice filtrate, vacuum decompression distills to obtain mastic, and drying and crushing obtains powder; (2) by levan, Radix Glycyrrhizae, Fructus Crataegi, Fructus Jujubae, spirulina proportionally, be placed in pulverizer and pulverize, cross 200 mesh standard sieves and obtain mixed-powder; (3) step (1) gained powder and step (2) gained powder are stirred 2 hours, mixing; (4) step (3) gained is added suitable adjuvant, be prepared into corresponding dosage form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510168828.2A CN104721685A (en) | 2015-04-07 | 2015-04-07 | Chinese herba preparation capable of regulating gastrointestinal flora disequilibrium and preparation method of Chinese herba preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510168828.2A CN104721685A (en) | 2015-04-07 | 2015-04-07 | Chinese herba preparation capable of regulating gastrointestinal flora disequilibrium and preparation method of Chinese herba preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104721685A true CN104721685A (en) | 2015-06-24 |
Family
ID=53446481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510168828.2A Pending CN104721685A (en) | 2015-04-07 | 2015-04-07 | Chinese herba preparation capable of regulating gastrointestinal flora disequilibrium and preparation method of Chinese herba preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104721685A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107050349A (en) * | 2017-05-04 | 2017-08-18 | 南京苏新智慧社区服务有限公司 | A kind of cream taste of toxin expelling promoting blood circulation and its preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103054938A (en) * | 2013-01-31 | 2013-04-24 | 哈药集团中药二厂 | Oral preparation for conditioning stomach and intestine dysbacteriosis |
| CN104383046A (en) * | 2014-11-10 | 2015-03-04 | 黄结云 | Medicament for treating infantile diarrhea |
-
2015
- 2015-04-07 CN CN201510168828.2A patent/CN104721685A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103054938A (en) * | 2013-01-31 | 2013-04-24 | 哈药集团中药二厂 | Oral preparation for conditioning stomach and intestine dysbacteriosis |
| CN104383046A (en) * | 2014-11-10 | 2015-03-04 | 黄结云 | Medicament for treating infantile diarrhea |
Non-Patent Citations (5)
| Title |
|---|
| 徐德生等: "麦冬多糖MDG-1的分离纯化和结构分析", 《药学学报》 * |
| 王欢等: "七味白术散调节肠道微生态的物质基础", 《世界华人消化杂志》 * |
| 空间营养学: "《空间营养学》", 31 May 2011, 国防工业出版社 * |
| 陶金华等: "肠道微生态与中药有效成分代谢的相互作用", 《中草药》 * |
| 黄兆胜主编: "《中药学》", 30 June 2010, 人民卫生出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107050349A (en) * | 2017-05-04 | 2017-08-18 | 南京苏新智慧社区服务有限公司 | A kind of cream taste of toxin expelling promoting blood circulation and its preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102048933B (en) | Chinese medicinal composition for treating infantile diarrhea and preparation method thereof | |
| CN102068707B (en) | Traditional Chinese medicine contrast medium adjuvant used for B ultrasonic and preparation method thereof | |
| CN103405728B (en) | A kind of Chinese medicine composition for the treatment of climacteric syndrome and preparation method thereof | |
| CN104922550A (en) | Traditional Chinese medicine combination and application thereof | |
| CN105213941A (en) | A kind of Chinese medicine composition being used for the treatment of infantile diarrhea and preparation method thereof | |
| CN103041256B (en) | Chinese herb preparation for curing recurrent respiratory tract infection of children | |
| CN104784624A (en) | Traditional Chinese medicine for treating dyspepsia | |
| CN104324189A (en) | Intestine-moistening and bowel-releasing health-caring product | |
| CN103041257B (en) | Chinese materia medica preparation for curing high fever and respiratory tract infection of children | |
| CN104547622A (en) | Traditional Chinese medicine preparation for treating cataract and preparation method of traditional Chinese medicine preparation | |
| CN104304809B (en) | Milk cow in lactation period feed additive and application thereof | |
| CN103041255B (en) | Chinese materia medica preparation for curing swollen sore throat and respiratory tract infection of children | |
| CN104721685A (en) | Chinese herba preparation capable of regulating gastrointestinal flora disequilibrium and preparation method of Chinese herba preparation | |
| CN102178866A (en) | Chinese medicinal preparation for dispelling damp, promoting blood circulation, softening hard mass and eliminating stagnation for people with qi-depression and blood-stagnation physique, preparation method thereof and application thereof | |
| CN104435744A (en) | Traditional Chinese medicine thick paste for treating functional dyspepsia and preparation method of traditional Chinese medicine thick paste | |
| CN103041258B (en) | Chinese materia medica preparation for curing respiratory tract infection with poor appetite of children | |
| CN106334155A (en) | Traditional Chinese medicine composition for treating arterial thyromegaly and preparation method thereof | |
| CN105796815A (en) | Kidney-reinforcing and bone-strengthening liquor and preparation method thereof | |
| CN106165807A (en) | A kind of replenishing YIN and removing heat the kidney invigorating beverage and preparation processing method | |
| CN106138603A (en) | A kind of invigorating the kidney and strengthening the bones wine and preparation method thereof | |
| CN105381409A (en) | Medicine for treating cholelithiasis and preparation method of medicine | |
| CN104784401A (en) | Traditional Chinese medicine preparation for treating stomach cancer | |
| CN104116920A (en) | Viable bacteria mixture for treating diarrhea with flatulence and preparation method thereof | |
| CN103041259B (en) | Chinese materia medica preparation for curing excessive phlegm, cough and respiratory tract infection of children | |
| CN102166295B (en) | Traditional Chinese medicine composition for treating carcinosis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150624 |