CN105343462A - Medicine for treating osteomyelitis and preparation method of medicine - Google Patents

Medicine for treating osteomyelitis and preparation method of medicine Download PDF

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CN105343462A
CN105343462A CN201510949117.9A CN201510949117A CN105343462A CN 105343462 A CN105343462 A CN 105343462A CN 201510949117 A CN201510949117 A CN 201510949117A CN 105343462 A CN105343462 A CN 105343462A
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radix
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rhizoma
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张朝兰
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
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Abstract

The invention discloses a medicine for treating osteomyelitis and a preparation method of the medicine. The medicine is mainly prepared from prepared rehmannia roots, astragalus membranaceus, honeysuckle, plantain seeds, mongolian snakegourd roots, rhizome of paniculate bolbostemma, suberect spatholobus stems, safflower, malaytea scurfpea fruits, rehmannia roots, pawpaw, giant knotweed rhizome, largetrifoliolious bugbane rhizome, fortune's drynaria rhizome, dahurian angelica roots, twotooth achyranthes roots, cicada slough, divaricate saposhnikovia roots, golden thread, philippine violet herb, Chinese honeylocust spine, liquorice and moutan bark by weight. The medicine has the functions of heat clearing, detoxification, kidney yang warming and invigorating, promotion of blood circulation to remove obstructions in meridians, stomach regulating and dampness removal, takes effect quickly when used for treating osteomyelitis and has a good curative effect, and osteomyelitis does not relapse.

Description

One treats myelitic medicine and preparation method thereof
Technical field
The present invention relates to one and treat myelitic medicine and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Osteomyelitis refers to a kind of infection and destruction of bone, can by aerobic or anaerobe, and mycobacteria and fungus cause.The traditional Chinese medical science then thinks the category belonging to pyogenic infection of the bone, carbuncle of yin nature.Because western medicine side effect is large, therefore there is great demand to effectively treating myelitic Chinese medicine in people, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the effectively myelitic medicine for the treatment of, thus completes the present invention.
Object of the present invention is just to provide the myelitic Chinese medicine composition of a kind of effectively treatment.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Radix Rehmanniae Preparata, the Radix Astragali, Radix Codonopsis, Flos Lonicerae, Semen Plantaginis, Herba Euphorbiae Helioscopiae, Radix Trichosanthis, Rhizoma Bolbostematis, Caulis Spatholobi, Flos Carthami, Fructus Psoraleae, Herba Sambuci Adnatae, Radix Rehmanniae, Fructus Chaenomelis, Rhizoma Polygoni Cuspidati, Radix et Rhizoma Dispori Cantoniensis, Rhizoma Cimicifugae, Eupolyphaga Seu Steleophaga, Rhizoma Drynariae, the Radix Angelicae Dahuricae, Radix Achyranthis Bidentatae, Fructus Forsythiae, Periostracum Cicadae, Radix Saposhnikoviae, Rhizoma Coptidis, Herba Violae, Herba Boenninghauseniae, Spina Gleditsiae, Radix Glycyrrhizae, Cortex Moutan medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat osteomyelitis.Wherein select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty, chronic diarrhea, proctoptosis.Flos Lonicerae is selected to be because its nature and flavor are sweet, cold, enter lung, stomach warp, have heat clearing away, the function of removing toxic substances, control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Semen Plantaginis is selected to be that cold, enter kidney, urinary bladder channel, have diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, and arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view because its nature and flavor are sweet.Herba Euphorbiae Helioscopiae is selected to be that cool, poisonous, enter large and small intestinal, spleen, have row water, expectorant, parasite killing, the function of removing toxic substances, controls edematous asthma, and phlegm retention is breathed with cough, malaria, scrofula, tinea skin ulcer, Tuberculous flaccidity pipe, osteomyelitis because its nature and flavor are worked hard.Radix Trichosanthis is selected to be that cool, enter lung, stomach warp, have and promote the production of body fluid, quench the thirst, pathogenic fire reducing, moisturize, evacuation of pus, the function of detumescence, controls calentura thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula because its nature and flavor sweetness and bitterness acid.Select Rhizoma Bolbostematis to be because its nature and flavor are bitter, be slightly cold, return lung, spleen channel, have eliminating stagnation poison, the function of subduing inflammation, controls acute mastitis, scrofula sucutaneous nodule, sore swollen toxin and snakeworm poison.Select Caulis Spatholobi to be because its property bitter but sweet flavor, temperature, enters the heart, spleen two warp, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Flos Carthami to be that temperature, enters the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, control amenorrhea , mass in the abdomen because its nature and flavor are pungent, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Fructus Psoraleae is that temperature, enter kidney channel, have the function of reinforcing the kidney and supporting YANG, control cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and coughed because its nature and flavor are pungent.Select Herba Sambuci Adnatae to be because its property acrid-sweet flavor, temperature, dispels the wind, diuretic, dissipating blood stasis, the function of dredging collateral, and dispelling the wind and dampness pathogens pain, sprains, fracture.Select Radix Rehmanniae to be that cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, the function of promoting the production of body fluid, and controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, and interior-heat is quenched one's thirst because its nature and flavor are sweet, spit blood, epistaxis, sends out speckle dermexanthesis.Fructus Chaenomelis is selected to be that temperature, enters liver, spleen channel, have suppressing the hyperactive liver and easing the stomach, the function of the relaxing muscles and tendons that dries, and controls convulsion of vomiting and diarrhoea, arthralgia chiefly caused by damp pathogen, beriberi, edema, dysentery because its nature and flavor acid.Rhizoma Polygoni Cuspidati is selected to be because its nature and flavor are bitter, flat, return liver, gallbladder, lung meridian, dispel the wind, dampness removing, removing blood stasis with potent drugs, the function of stimulating the menstrual flow, dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis lumps in the chest and abdomen, anal fistula hematochezia, injury from falling down, scalds, malignant boil tinea disease.Select Radix et Rhizoma Dispori Cantoniensis to be that cool, have heat-clearing and toxic substances removing, the function of relaxing muscles and tendons to promote blood circulation, controls hyperpyrexia because its nature and flavor toil, rheumatism is benumbed, joint, lumbago and skelalgia.Rhizoma Cimicifugae is selected to be because the sweet pungent micro-hardship of its nature and flavor, cool, enter lung, spleen, stomach warp, have yang invigorating, deliver, rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, laryngalgia, aphtha scar, and macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus drops, carbuncle sore tumefacting virus.Select Eupolyphaga Seu Steleophaga to be salty because of its nature and flavor, cold, slightly poisonous, return Liver Channel, have removing blood stasis with potent drugs blood, the function of reuniting the fractured tendons and bones, controls injured bone, blood stasis amenorrhea , mass in the abdomen mass in the abdomen.Rhizoma Drynariae is selected to be that temperature, enters liver, kidney channel, have the kidney invigorating, invigorate blood circulation, the function of hemostasis, control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus because its nature and flavor are bitter.Select the Radix Angelicae Dahuricae to be that temperature, enters lung, spleen, stomach warp, dispel the wind, dampness because its nature and flavor are pungent, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, and cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid, flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and the function of subduing inflammation, controls gonorrhea, hematuria, amenorrhea , mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury, ripe invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Select Fructus Forsythiae to be because its nature and flavor are bitter, cool, enter the heart, liver, gallbladder meridian, have heat clearing away, removing toxic substances, eliminating stagnation, the function of detumescence, controls warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Select Periostracum Cicadae to be because its property sweet-salty, cool, enter lung, Liver Channel, have loose wind heat, lung qi dispersing, determine the function of convulsion, control affection due to external wind and heat, cough hoarseness, measles is sent out not smooth thoroughly, and rubella pruritus, little youngster shies Epilepsy, conjunctival congestion, cataracta, furuncle swelling toxin, tetanus.Select Radix Saposhnikoviae to be because its property acrid-sweet flavor, temperature, enters bladder, lung, spleen channel, delivers, dispel the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, anemofrigid-damp arthralgia, and joint is ached, and extremity contraction is anxious, tetanus.Rhizoma Coptidis is selected to be because its nature and flavor are bitter, cold, enter the heart, liver, stomach, large intestine channel, have pathogenic fire purging, dampness, removing toxic substances, the function of parasite killing, row pyretic toxicity, typhoid fever when controlling, intenseness of heat is vexed, feeling of fullness vomiting, bacillary dysentery, and diarrhea of heat type is suffered from abdominal pain, pulmonary tuberculosis, tells, is defeated in battle, hematochezia, quenches one's thirst, infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.Select Herba Violae to be that GUIXIN, Liver Channel, have heat-clearing and toxic substances removing because its nature and flavor bitter, acrid, cold, the function of removing heat from blood detumescence, controls furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.Herba Boenninghauseniae is selected to be that return lung, stomach warp, has heat-clearing and toxic substances removing, and the function of promoting blood circulation and stopping pain, cures cold, tonsillitis, parotitis, bronchitis because its nature and flavor are bitter, pungent, cool, slightly poisonous, stomachache abdominal distention, thromboangiitis obliterans, lumbago, traumatic injury.Select Spina Gleditsiae to be because its nature and flavor are pungent, temperature, return liver, stomach warp, searches wind, draws out pus by applying a plaster to the affected part, and detumescence, the function of evacuation of pus, controls carbuncle, sore, leprosy, tinea skin ulcer, placenta retention.Select Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, processs use, controls weakness of the spleen and stomach, lack of appetite, stomachache loose stool, and overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus , Jing Epilepsy; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle , Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea , mass in the abdomen, carbuncle and ulcer, flutters damage.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight
Radix Rehmanniae Preparata 12-18 gram, Radix Astragali 8-12 gram, Radix Codonopsis 8-12 gram, Flos Lonicerae 10-15 gram, Semen Plantaginis 8-12 gram, Herba Euphorbiae Helioscopiae 6-10 gram, Radix Trichosanthis 8-12 gram, Rhizoma Bolbostematis 8-12 gram, Caulis Spatholobi 10-15 gram, Flos Carthami 8-12 gram, Fructus Psoraleae 8-12 gram, Herba Sambuci Adnatae 15-25 gram, Radix Rehmanniae 12-18 gram, Fructus Chaenomelis 8-12 gram, Rhizoma Polygoni Cuspidati 25-35 gram, Radix et Rhizoma Dispori Cantoniensis 15-25 gram, Rhizoma Cimicifugae 8-12 gram, Eupolyphaga Seu Steleophaga 3-6 gram, Rhizoma Drynariae 8-12 gram, Radix Angelicae Dahuricae 10-15 gram, Radix Achyranthis Bidentatae 10-15 gram, Fructus Forsythiae 8-12 gram, Periostracum Cicadae 8-12 gram, Radix Saposhnikoviae 10-15 gram, Rhizoma Coptidis 8-12 gram, Herba Violae 10-15 gram, Herba Boenninghauseniae 6-10 gram, Spina Gleditsiae 8-12 gram, Radix Glycyrrhizae 10-15 gram, Cortex Moutan 8-12 gram.
Be preferably
Radix Rehmanniae Preparata 15 grams, the Radix Astragali 10 grams, Radix Codonopsis 10 grams, Flos Lonicerae 12 grams, Semen Plantaginis 10 grams, Herba Euphorbiae Helioscopiae 8 grams, Radix Trichosanthis 10 grams, Rhizoma Bolbostematis 10 grams, Caulis Spatholobi 12 grams, 10 grams, Flos Carthami, Fructus Psoraleae 10 grams, Herba Sambuci Adnatae 20 grams, Radix Rehmanniae 15 grams, Fructus Chaenomelis 10 grams, Rhizoma Polygoni Cuspidati 30 grams, Radix et Rhizoma Dispori Cantoniensis 20 grams, Rhizoma Cimicifugae 10 grams, Eupolyphaga Seu Steleophaga 5 grams, Rhizoma Drynariae 10 grams, the Radix Angelicae Dahuricae 12 grams, Radix Achyranthis Bidentatae 12 grams, Fructus Forsythiae 10 grams, Periostracum Cicadae 10 grams, Radix Saposhnikoviae 12 grams, Rhizoma Coptidis 10 grams, Herba Violae 12 grams, Herba Boenninghauseniae 8 grams, Spina Gleditsiae 10 grams, 12 grams, Radix Glycyrrhizae, Cortex Moutan 10 grams.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;
2, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
3, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
4, Flos Lonicerae: sieve removes silt, picks clean impurity;
5, Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;
6, Herba Euphorbiae Helioscopiae: get crude drug, removing undesirable root, impurity, cleans, slightly moistens, cutting, dry;
7, Radix Trichosanthis: pick decontamination, size block is separately, saturating with blister about sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries; Or wash, pull out, shine extremely dry, be pounded fritter;
8, Rhizoma Bolbostematis: autumn, winter excavate, cleans, breaks into two with one's hands, boils to without the white heart, takes out, dry;
9, Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;
10, Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
11, Fructus Psoraleae: most impurity of winnowing with a dustpan, cleans, dries;
12, Herba Sambuci Adnatae: Xia Qiu gathers, chopping, dries;
13, Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;
14, Fructus Chaenomelis: clear water is cleaned, and slightly soaks, moistening, to thoroughly, is put in food steamer and is cooked, take advantage of fervent sheet, weather exposure, with by the red atropurpureus that turns for degree;
15, Rhizoma Polygoni Cuspidati: spring and autumn excavates, cleans, dries;
16, Radix et Rhizoma Dispori Cantoniensis: excavate between the autumn in summer, cleans, dries;
17, Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
18, Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;
19, Rhizoma Drynariae: remove sediment contamination, cleans, slightly soaks, run through, and section, dries;
20, the Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;
21, Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;
22, Fructus Forsythiae: pick clean impurity, stranding is opened, except discarding stalk;
23, Periostracum Cicadae: pick decontamination, cleans and dries;
24, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
25, Rhizoma Coptidis: pick decontamination, cleans silt particle, runs through, and section, dries in the shade;
26, Herba Violae: get crude drug, removing impurity, cleans, slightly dries in the air, cutting, dry;
27, Herba Boenninghauseniae: autumn extracts, clean, cutting, dries;
28, Spina Gleditsiae: pick decontamination, is soaked in water, and runs through rear section, dries;
29, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through section, dry;
30, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries.
Two, prepare
1, by the Radix Rehmanniae Preparata of described weight, the Radix Astragali, Radix Codonopsis, Flos Lonicerae, Semen Plantaginis, Herba Euphorbiae Helioscopiae, Radix Trichosanthis, Rhizoma Bolbostematis, Caulis Spatholobi, Flos Carthami, Fructus Psoraleae, Herba Sambuci Adnatae, Radix Rehmanniae, Fructus Chaenomelis, Rhizoma Polygoni Cuspidati, Radix et Rhizoma Dispori Cantoniensis, Rhizoma Cimicifugae, Eupolyphaga Seu Steleophaga, Rhizoma Drynariae, the Radix Angelicae Dahuricae, Radix Achyranthis Bidentatae, Fructus Forsythiae, Periostracum Cicadae, Radix Saposhnikoviae, Rhizoma Coptidis, Herba Violae, Herba Boenninghauseniae, Spina Gleditsiae, Radix Glycyrrhizae, Cortex Moutan puts into decocting container, add water 8 times amount for the first time, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.
2, add water the medicinal residues of filtration 6 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor.
3, by twice decoction liquor mixing and stirring and get final product, 4 doses are divided into take.
In prescription, Fructus Psoraleae has the function of reinforcing the kidney and supporting YANG to be monarch drug; Rhizoma Drynariae the kidney invigorating, invigorates blood circulation, hemostasis; Rhizoma Polygoni Cuspidati dispels the wind, dampness removing, removing blood stasis with potent drugs, the function of stimulating the menstrual flow, the two is ministerial drug, and three taste medicines play the kidney invigorating jointly, invigorate blood circulation, removing blood stasis with potent drugs, the effect of dampness removing, treatment osteomyelitis effect is comprehensive, and with the kidney invigorating, invigorating blood circulation is that master can be effected a permanent cure, and Fructus Chaenomelis has suppressing the hyperactive liver and easing the stomach, the function of relaxing muscles and tendons of drying is adjuvant drug, and Radix Glycyrrhizae has and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, for making medicine, is take stopgap measures with all medicines of remainder.
Medicine of the present invention has heat-clearing and toxic substances removing, warming and recuperating the kidney-YANG, promoting blood circulation to remove obstruction in the collateral, and the function of stomach function regulating damp eliminating, is used for the treatment of osteomyelitis, short treating period, instant effect, non-relapse after healing.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Taking medicinal liquid super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, twice daily, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept osteomyelitis out-patient totally 30 examples for medical treatment.
2, diagnostic criteria
Symptom is patient's recurrent exerbation, high heat, local pain during acute osteomyelitis onset, has diabrosis, suppurates, has sequestrum or cavity to be formed when transferring to chronic.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 15 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: osteomyelitis transference cure, body constitution recovers normal, recovery from illness;
Take a turn for the better: patient affected part pain phenomenon alleviates, temperature recovery is normal, and osteomyelitis symptom is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy osteomyelitis (co) 30 example of the present invention, effective 22 examples of result, obvious effective rate is 73.33%, and take a turn for the better 6 examples, and improvement rate is 20%, and invalid 2 examples, total effective rate is 93.33%.

Claims (3)

1. treat a myelitic medicine, it is characterized in that: it is made up of the crude drug in following weight range:
Radix Rehmanniae Preparata 12-18 gram, Radix Astragali 8-12 gram, Radix Codonopsis 8-12 gram, Flos Lonicerae 10-15 gram, Semen Plantaginis 8-12 gram, Herba Euphorbiae Helioscopiae 6-10 gram, Radix Trichosanthis 8-12 gram, Rhizoma Bolbostematis 8-12 gram, Caulis Spatholobi 10-15 gram, Flos Carthami 8-12 gram, Fructus Psoraleae 8-12 gram, Herba Sambuci Adnatae 15-25 gram, Radix Rehmanniae 12-18 gram, Fructus Chaenomelis 8-12 gram, Rhizoma Polygoni Cuspidati 25-35 gram, Radix et Rhizoma Dispori Cantoniensis 15-25 gram, Rhizoma Cimicifugae 8-12 gram, Eupolyphaga Seu Steleophaga 3-6 gram, Rhizoma Drynariae 8-12 gram, Radix Angelicae Dahuricae 10-15 gram, Radix Achyranthis Bidentatae 10-15 gram, Fructus Forsythiae 8-12 gram, Periostracum Cicadae 8-12 gram, Radix Saposhnikoviae 10-15 gram, Rhizoma Coptidis 8-12 gram, Herba Violae 10-15 gram, Herba Boenninghauseniae 6-10 gram, Spina Gleditsiae 8-12 gram, Radix Glycyrrhizae 10-15 gram, Cortex Moutan 8-12 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Rehmanniae Preparata 15 grams, the Radix Astragali 10 grams, Radix Codonopsis 10 grams, Flos Lonicerae 12 grams, Semen Plantaginis 10 grams, Herba Euphorbiae Helioscopiae 8 grams, Radix Trichosanthis 10 grams, Rhizoma Bolbostematis 10 grams, Caulis Spatholobi 12 grams, 10 grams, Flos Carthami, Fructus Psoraleae 10 grams, Herba Sambuci Adnatae 20 grams, Radix Rehmanniae 15 grams, Fructus Chaenomelis 10 grams, Rhizoma Polygoni Cuspidati 30 grams, Radix et Rhizoma Dispori Cantoniensis 20 grams, Rhizoma Cimicifugae 10 grams, Eupolyphaga Seu Steleophaga 5 grams, Rhizoma Drynariae 10 grams, the Radix Angelicae Dahuricae 12 grams, Radix Achyranthis Bidentatae 12 grams, Fructus Forsythiae 10 grams, Periostracum Cicadae 10 grams, Radix Saposhnikoviae 12 grams, Rhizoma Coptidis 10 grams, Herba Violae 12 grams, Herba Boenninghauseniae 8 grams, Spina Gleditsiae 10 grams, 12 grams, Radix Glycyrrhizae, Cortex Moutan 10 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;
(2) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
(3) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
(4) Flos Lonicerae: sieve removes silt, picks clean impurity;
(5) Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;
(6) Herba Euphorbiae Helioscopiae: get crude drug, removing undesirable root, impurity, cleans, slightly moistens, cutting, dry;
(7) Radix Trichosanthis: pick decontamination, size block is separately, saturating with blister about sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries; Or wash, pull out, shine extremely dry, be pounded fritter;
(8) Rhizoma Bolbostematis: autumn, winter excavate, cleans, breaks into two with one's hands, boils to without the white heart, takes out, dry;
(9) Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;
(10) Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;
(11) Fructus Psoraleae: most impurity of winnowing with a dustpan, cleans, dries;
(12) Herba Sambuci Adnatae: spring and autumn gathers, chopping, dries;
(13) Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;
(14) Fructus Chaenomelis: clear water is cleaned, and slightly soaks, moistening, to thoroughly, is put in food steamer and is cooked, take advantage of fervent sheet, weather exposure, with by red turn atropurpureus till;
(15) Rhizoma Polygoni Cuspidati: spring and autumn excavates, cuts off, dries;
(16) Radix et Rhizoma Dispori Cantoniensis: excavate between the autumn in summer, cleans, dries;
(17) Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
(18) Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;
(19) Rhizoma Drynariae: remove sediment contamination, cleans, slightly soaks, run through, and section, dries;
(20) Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;
(21) Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;
(22) Fructus Forsythiae: pick clean impurity, stranding is opened, except discarding stalk;
(23) Periostracum Cicadae: pick decontamination, cleans and dries;
(24) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
(25) Rhizoma Coptidis: pick decontamination, cleans silt particle, runs through, and section, dries in the shade;
(26) Herba Violae: get crude drug, removing impurity, cleans, slightly dries in the air, cutting, dry;
(27) Herba Boenninghauseniae: autumn extracts, clean, cutting, dries;
(28) Spina Gleditsiae: pick decontamination, is soaked in water, and runs through rear section, dries;
(29) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through section, dry;
(30) Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;
(2) prepare
(1) by the Radix Rehmanniae Preparata of described weight, the Radix Astragali, Radix Codonopsis, Flos Lonicerae, Semen Plantaginis, Herba Euphorbiae Helioscopiae, Radix Trichosanthis, Rhizoma Bolbostematis, Caulis Spatholobi, Flos Carthami, Fructus Psoraleae, Herba Sambuci Adnatae, Radix Rehmanniae, Fructus Chaenomelis, Rhizoma Polygoni Cuspidati, Radix et Rhizoma Dispori Cantoniensis, Rhizoma Cimicifugae, Eupolyphaga Seu Steleophaga, Rhizoma Drynariae, the Radix Angelicae Dahuricae, Radix Achyranthis Bidentatae, Fructus Forsythiae, Periostracum Cicadae, Radix Saposhnikoviae, Rhizoma Coptidis, Herba Violae, Herba Boenninghauseniae, Spina Gleditsiae, Radix Glycyrrhizae, Cortex Moutan puts into decocting container, add water 8 times amount, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container,
(2) add water the medicinal residues of filtration 6 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;
(3) by twice decoction liquor mixing and stirring and get final product, 4 doses are divided into take.
CN201510949117.9A 2015-12-18 2015-12-18 Medicine for treating osteomyelitis and preparation method of medicine Pending CN105343462A (en)

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