CN103638403B - Medicine for treating diabetic gangrene and preparation method of medicine - Google Patents

Abstract

The invention discloses a medicine for treating medicine for treating diabetic gangrene and a preparation method of the medicine. The medicine is mainly prepared from astragalus membranaceus, radix scrophulariae, achyranthes bidentata, prepared rehmannia, honeysuckle, heterophylly falsestarwort root, motherwort, red peony root, radix ophiopogonis and other medicines in a certain weight ratio. The medicine has the functions of clearing heat and cooling blood, eliminating stasis and removing toxicity, is quick in response and good in curative effect when used for treating diabetic gangrene, and does not have toxic or side effect.

Description

A kind of medicine for the treatment of diabetic acromelic gangrene and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of diabetic acromelic gangrene and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Diabetic acromelic gangrene is that a kind of chronic progressive external involves big or middle, the microvascular special pathological changes of limbs, with acral pain, infection, ulcer, gangrene for main clinical characteristics.This disease is one of complication that diabetes are the most serious.This patient is and digital ulcer inaccessible with large artery trunks usually.And this digital ulcer is perception gangrene; If patient is without arterial occlusion, then ulcer is sent out well at the place such as its sufficient edge, vola, instep, and this ulcer is wet gangrene, this disease is mainly in diabetics and well controls caused by blood glucose.Diabetic acromelic gangrene betides middle-aged and elderly people mostly; Man is more than female, and the ratio of men and women is 3:2; Diabetic duration on average about 10 years, gangrenous position lower limb are common, and account for 92.5%, upper limb is rare, and morbidity accounts for 80%, and bilateral is fallen ill simultaneously and accounted for 20%; The while of toes and vola, gangrene is common, accounts for 77.5%; Toes and shank simultaneously gangrene account for 5%, and only shank gangrene accounts for 5%; Toes or finger morbidity account for 12.5%.At present, diabetes treatment by western medicine acromelic gangrene poor effect, and long-term taking Western medicine has more side effect, therefore, there is very large demand to the Chinese medicine of effectively treating diabetic acromelic gangrene in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment diabetic acromelic gangrene, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating diabetic acromelic gangrene.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects the Radix Astragali, Radix Scrophulariae, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Flos Lonicerae, Radix Pseudostellariae, Herba Leonuri, Radix Paeoniae Rubra, Radix Ophiopogonis, Radix Angelicae Sinensis, Caulis Spatholobi, the Rhizoma Anemarrhenae, Lumbricus, Lignum Sappan, Radix Trichosanthis, Herba Epimedii, Semen Coicis, Rhizoma Atractylodis, Cortex Moutan, Radix Gentianae, Flos Carthami, Herba Violae, Radix Aconiti Lateralis Preparata, Rhizoma Sparganii, Herba Eupatorii, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cimicifugae, Radix Rhapontici, Rhizoma Corydalis, Concha Margaritifera medicine to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of rapid, effective treatment diabetic acromelic gangrene.Wherein select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Radix Scrophulariae to be because its nature and flavor are bitter, salty, cool, enter lung, kidney channel, have YIN nourishing, pathogenic fire reducing, relieving restlessness, the function of removing toxic substances, control calentura excessive thirst, send out speckle, hectic fever due to YIN-deficiency consumptive fever, sleep night not peaceful, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid, flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and the function of subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury, ripe invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Flos Lonicerae is selected to be because its nature and flavor are sweet, cold, enter lung, stomach warp, have heat clearing away, the function of removing toxic substances, control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Radix Pseudostellariae is selected to be that tepor, enters the heart, spleen, lung three warp, have the function of tonifying the lung, spleen invigorating, control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus order antiperspirant, metal fatigue because its nature and flavor sweetness and bitterness.Select Herba Leonuri to be that cool, enter pericardium, Liver Channel, invigorate blood circulation, blood stasis dispelling, regulating menstruation, the function of the water that disappears, controls menoxenia because its nature and flavor are worked hard, control and Lou have difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, control warm poison and go mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Select be because its property sweet and slightly bitter taste Radix Ophiopogonis, cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, and the function of reinforcing stomach reg fluid controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, and clearly yearningly, calentura Tianjin is hindered, dry mouth and throat, constipation.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Caulis Spatholobi to be because its property bitter but sweet flavor, temperature, enters the heart, spleen two warp, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.The Rhizoma Anemarrhenae is selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Lumbricus is selected to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, have heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control high fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select Lignum Sappan to be because its nature and flavor are sweet, salty, flat, have promoting the circulation of blood, removing blood stasis with potent drugs, detumescence, the function of pain relieving, controls married woman's vim and vigour cardiac and abdominal pain, amenorrhea, postnatal blood stasis, distending pain dyspnea with rapid respiration, dysentery, tetanus.Radix Trichosanthis is selected to be that cool, enter lung, stomach warp, have and promote the production of body fluid, quench the thirst, pathogenic fire reducing, moisturize, evacuation of pus, the function of detumescence, controls calentura thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula because its nature and flavor sweetness and bitterness acid.Select Herba Epimedii to be because its property acrid-sweet flavor, temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting, the function of expelling wind and removing dampness, control sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, and hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Semen Coicis is selected to be that cool, enter spleen, lung, kidney channel, have spleen invigorating, tonifying the lung, heat clearing away, the function of dampness removing, controls and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea because its property slightly sweet flavor.Rhizoma Atractylodis are selected to be that temperature, enters spleen, stomach warp, have spleen invigorating, dampness, resolving depression, ward off dirty function because its nature and flavor are worked hard, control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle ， Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.Select Radix Gentianae to be that cold, enter liver, gallbladder meridian, have eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B because its nature and flavor are bitter, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Select Flos Carthami to be that temperature, enters the heart, Liver Channel, have promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, control amenorrhea ， mass in the abdomen because its nature and flavor are pungent, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Herba Violae is selected to be that cold, enter the heart, Liver Channel, have clearing away heat-damp and promoting diuresis, the function of removing toxic substances and promoting subsidence of swelling, controls furuncle, carbuncle, scrofula, jaundice, dysentery because its nature and flavor are bitter, diarrhoea, conjunctival congestion, sore throat, venom.Radix Aconiti Lateralis Preparata is selected to be because its property acrid-sweet flavor, heat, poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted inverse, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia ， Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Select Rhizoma Sparganii to be because its nature and flavor toil, flat, enter liver, spleen channel, have removing blood stasis, circulation of qi promoting, removing food stagnancy, the function ， Zhi lumps in the chest and abdomen of pain relieving, the solidifying band of QI and blood, trusted subordinate's pain, the lower swollen pain of the side of body, amenorrhea, postnatal blood stasis is suffered from abdominal pain, and traumatic injury, skin ulcer swells hard.Select Herba Eupatorii to be that flat, enter spleen, stomach warp, have clearing away summer-heat, ward off dirty, removing dampness, the function of regulating menstruation, controls and experience heat-damp in summer because its nature and flavor are pungent, cold and heat are had a headache, and accumulate in damp, gastral cavity painful abdominal mass is not hungry, sweet taste in the mouth greasy fur, menoxenia.Select Pseudobulbus Bletillae (Rhizoma Bletillae) to be because its property bitter but sweet flavor, cool, enter lung meridian, have tonifying the lung, hemostasis, detumescence, raw sight, the function of sore, control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis.Rhizoma Cimicifugae is selected to be because the sweet pungent micro-hardship of its nature and flavor, cool, enter lung, spleen, stomach warp, have yang invigorating, deliver, rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, laryngalgia, aphtha scar, and macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus drops, carbuncle sore tumefacting virus.Select Radix Rhapontici to be because its nature and flavor hardship is salty-cold, enter stomach, large intestine channel, have heat-clearing and toxic substances removing, the function of stimulating milk secretion, control the swollen pain of breast, galactostasis, toxic-heat and blood stasis, arthralgia.Rhizoma Corydalis is selected to be that temperature, enter liver, stomach warp, invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, the function of pain relieving, controls all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury because its nature and flavor are worked hard.Select Concha Margaritifera to be because its nature and flavor are salty, cool, enter the heart, liver two warp, have suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, the function of hemostasis, controls dizziness, tinnitus, cardiopalmus, insomnia, and demented ， Jing Epilepsy is spitted blood, epistaxis, metrorrhagia.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Radix Astragali 15-25 gram of Radix Scrophulariae 15-25 gram of Radix Achyranthis Bidentatae 15-25 gram

Radix Rehmanniae Preparata 10-20 gram of Flos Lonicerae 10-20 gram of Radix Pseudostellariae 25-35 gram

Herba Leonuri 5-15 gram Radix Paeoniae Rubra 5-15 gram Radix Ophiopogonis 10-20 gram

Radix Angelicae Sinensis 10-20 gram of Caulis Spatholobi 10-20 gram of Rhizoma Anemarrhenae 25-35 gram

Lumbricus 10-20 gram of Lignum Sappan 10-15 gram of Radix Trichosanthis 5-15 gram

Herba Epimedii 5-15 gram of Semen Coicis 5-15 gram of Rhizoma Atractylodis 15-25 gram

Cortex Moutan 5-15 cron gallbladder 5-15 gram of Flos Carthami 10-20 gram

Herba Violae 6-12 gram of Radix Aconiti Lateralis Preparata 5-15 gram of Rhizoma Sparganii 5-15 gram

Herba Eupatorii 10-15 gram of Pseudobulbus Bletillae (Rhizoma Bletillae) 3-9 gram liter fiber crops 3-9 gram

Radix Rhapontici 10-20 gram of Rhizoma Corydalis 10-20 gram of Concha Margaritifera 25-35 gram

Preferable amount is

The Radix Astragali 20 grams of Radix Scrophulariaes 20 grams of Radix Achyranthis Bidentataes 20 grams

Radix Rehmanniae Preparata 15 grams of Flos Loniceraes 15 grams of Radix Pseudostellariaes 30 grams

Herba Leonuri 10 grams of Radix Paeoniae Rubra 10 grams of Radix Ophiopogonis 15 grams

Radix Angelicae Sinensis 15 grams of Caulis Spatholobis 15 grams of Rhizoma Anemarrhenaes 30 grams

Lumbricus 15 grams of Lignum Sappans 12 grams of Radix Trichosanthis 10 grams

Herba Epimedii 10 grams of Semen Coiciss 10 grams of Rhizoma Atractylodis 20 grams

15 grams, Cortex Moutan 10 cron gallbladder 10 grams of Flos Carthamis

Herba Violae 9 grams of Radix Aconiti Lateralis Preparatas 10 grams of Rhizoma Sparganii 10 grams

Herba Eupatorii 12 grams of Pseudobulbus Bletillae (Rhizoma Bletillae) 6 gram liter fiber crops 6 grams

Radix Rhapontici 15 grams of Rhizoma Corydalis 15 grams of Concha Margaritiferas 30 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;

2, Radix Scrophulariae: pick clean impurity, except removing LU, clean and run through, section, dries;

3, Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

4, Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;

5, Flos Lonicerae: sieve removes silt, picks clean impurity;

6, Radix Pseudostellariae: extract fibrous root, dry;

7, Herba Leonuri: pick decontamination, cleans, runs through, cutting, dry;

8, Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;

9, Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;

10, Radix Angelicae Sinensis: pick decontamination, clean, moistening, when slightly drying in the air even to inside and outside humidity, section is dried;

11, Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;

12, the Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;

13, Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;

14, Lignum Sappan: get crude drug, is sawn into short section, then is split into fragment or pound sheet;

15, Radix Trichosanthis: pick decontamination, size block is separately, saturating with blister sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, pull out, shine extremely dry, be pounded fritter;

16, Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;

17, Semen Coicis: get crude drug, removing residual cot, impurity;

18, Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;

19, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;

20, Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;

21, Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;

22, Herba Violae: pick clean impurity, wash earth with water, cutting, dry;

23, Radix Aconiti Lateralis Preparata: be soaked in water, pulls out, and section, dries;

24, Rhizoma Sparganii: pick clean impurity, be soaked in water, pull out and run through, section, dries;

25, Herba Eupatorii: pick clean impurity, wash, pull out, slightly after profit, removing undesirable root, cutting, dries;

26, Pseudobulbus Bletillae (Rhizoma Bletillae): pick decontamination, is soaked in water, and pulls out, runs through, section, dry;

27, Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;

28, Radix Rhapontici: pick clean impurity, unhairing is cleaned, and runs through, and section, dries;

29, Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

30, Concha Margaritifera: pick decontamination, knock fragment, sieve dedust bits.

Two, prepare

1, by the Radix Astragali of described weight, Radix Scrophulariae, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Flos Lonicerae, Radix Pseudostellariae, Herba Leonuri, Radix Paeoniae Rubra, Radix Ophiopogonis, Radix Angelicae Sinensis, Caulis Spatholobi, the Rhizoma Anemarrhenae, Lumbricus, Lignum Sappan, Radix Trichosanthis, Herba Epimedii, Semen Coicis, Rhizoma Atractylodis, Cortex Moutan, Radix Gentianae, Flos Carthami, Herba Violae, Radix Aconiti Lateralis Preparata, Rhizoma Sparganii, Herba Eupatorii, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cimicifugae, Radix Rhapontici, Rhizoma Corydalis, Concha Margaritifera medicine decocts with water secondary, add water 8 times amount for the first time, soak after 120 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.

2, add water the medicinal residues of filtration 6 times amount, first boils with high heat, then use slow fire boiling 40 minutes, filters to obtain second time decoction liquor.

3, twice decoction liquor is carried out mixing and stirring, be divided into 6 doses and take.

Medicine of the present invention has heat clearing away, removing heat from blood, and blood, repercussive, and the function of expectorant, is used for the treatment of diabetic acromelic gangrene, short treating period, instant effect, non-relapse after healing, has no side effect.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.4kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] drug treatment of diabetic acromelic gangrene of the present invention

1, physical data

Accept out-patient's totally 168 examples for medical treatment.

2, diagnostic criteria

Clinical acromelic gangrene is divided into wet gangrene, dry gangrene and mixed type gangrene.

(1) wet gangrene.Acra body surface local soft tissue is rotten to the corn, and form fester, then fester and go deep into muscle layer, very then rotten disconnected tendon, sclerotin is damaged, a large amount of tissue necrosis, forms large vomica, discharges more secretions.This kind of gangrene is common, accounts for 72.5%, and main pathological basis is microcirculation disturbance caused by blood capillary basement membrane thickened.

(2) dry gangrene.Get involved acra tip ischemic necrosis, withered blackening, lesion boundaries is clear, and being developed to that certain phase is not treated can self falling.This kind of gangrene accounts for 7.5%, ischemic necrosis caused by small artery obturation.

(3) mixed type gangrene.Account for 20%.Microcirculation disturbance and small artery block two class pathological changes and deposit, and the ischemia mummification necrosis of existing acra, has again the wet gangrene of foot and (or) shank.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 10 days, is a course for the treatment of, takes 7 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: transference cure, body constitution recovers normal, observes half a year without recidivist;

Take a turn for the better: symptom is clearly better, and body constitution is progressively recovered;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by drug treatment of diabetic acromelic gangrene patient 168 example of the present invention, effective 159 examples of result, obvious effective rate is 94.64%, and take a turn for the better 6 examples, and improvement rate is 3.57%, and invalid 3 examples, total effective rate is 98.21%.

Claims (3)

1. treat a medicine for diabetic acromelic gangrene, it is characterized in that: it is made up of the crude drug in following weight range:

Radix Astragali 15-25 gram of Radix Scrophulariae 15-25 gram of Radix Achyranthis Bidentatae 15-25 gram

Radix Rehmanniae Preparata 10-20 gram of Flos Lonicerae 10-20 gram of Radix Pseudostellariae 25-35 gram

Herba Leonuri 5-15 gram Radix Paeoniae Rubra 5-15 gram Radix Ophiopogonis 10-20 gram

Radix Angelicae Sinensis 10-20 gram of Caulis Spatholobi 10-20 gram of Rhizoma Anemarrhenae 25-35 gram

Lumbricus 10-20 gram of Lignum Sappan 10-15 gram of Radix Trichosanthis 5-15 gram

Herba Epimedii 5-15 gram of Semen Coicis 5-15 gram of Rhizoma Atractylodis 15-25 gram

Cortex Moutan 5-15 cron gallbladder 5-15 gram of Flos Carthami 10-20 gram

Herba Violae 6-12 gram of Radix Aconiti Lateralis Preparata 5-15 gram of Rhizoma Sparganii 5-15 gram

Herba Eupatorii 10-15 gram of Pseudobulbus Bletillae (Rhizoma Bletillae) 3-9 gram liter fiber crops 3-9 gram

Radix Rhapontici 10-20 gram of Rhizoma Corydalis 10-20 gram of Concha Margaritifera 25-35 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

The Radix Astragali 20 grams of Radix Scrophulariaes 20 grams of Radix Achyranthis Bidentataes 20 grams

Radix Rehmanniae Preparata 15 grams of Flos Loniceraes 15 grams of Radix Pseudostellariaes 30 grams

Herba Leonuri 10 grams of Radix Paeoniae Rubra 10 grams of Radix Ophiopogonis 15 grams

Radix Angelicae Sinensis 15 grams of Caulis Spatholobis 15 grams of Rhizoma Anemarrhenaes 30 grams

Lumbricus 15 grams of Lignum Sappans 12 grams of Radix Trichosanthis 10 grams

Herba Epimedii 10 grams of Semen Coiciss 10 grams of Rhizoma Atractylodis 20 grams

15 grams, Cortex Moutan 10 cron gallbladder 10 grams of Flos Carthamis

Herba Violae 9 grams of Radix Aconiti Lateralis Preparatas 10 grams of Rhizoma Sparganii 10 grams

Herba Eupatorii 12 grams of Pseudobulbus Bletillae (Rhizoma Bletillae) 6 gram liter fiber crops 6 grams

Radix Rhapontici 15 grams of Rhizoma Corydalis 15 grams of Concha Margaritiferas 30 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;

(2) Radix Scrophulariae: pick clean impurity, except removing LU, clean and run through, section, dries;

(3) Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

(4) Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;

(5) Flos Lonicerae: sieve removes silt, picks clean impurity;

(6) Radix Pseudostellariae: extract fibrous root, dry;

(7) Herba Leonuri: pick decontamination, cleans, runs through, cutting, dry;

(8) Radix Paeoniae Rubra: get crude drug, removing impurity, size stepping, cleans, runs through, shave, dry, and sieve removes chip;

(9) Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;

(10) Radix Angelicae Sinensis: pick decontamination, clean, moistening, when slightly drying in the air even to inside and outside humidity, section is dried;

(11) Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;

(12) Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;

(13) Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;

(14) Lignum Sappan: get crude drug, is sawn into short section, then is split into fragment or pound sheet;

(15) Radix Trichosanthis: pick decontamination, size block is separately, saturating with blister sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, pull out, shine extremely dry, be pounded fritter;

(16) Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;

(17) Semen Coicis: get crude drug, removing residual cot, impurity;

(18) Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;

(19) Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;

(20) Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;

(21) Flos Carthami: pick clean impurity, removing stem and leaf, base of a fruit head, dry;

(22) Herba Violae: pick clean impurity, wash earth with water, cutting, dry;

(23) Radix Aconiti Lateralis Preparata: be soaked in water, pulls out, and section, dries;

(24) Rhizoma Sparganii: pick clean impurity, be soaked in water, pull out and run through, section, dries;

(25) Herba Eupatorii: pick clean impurity, wash, pull out, slightly after profit, removing undesirable root, cutting, dries;

(26) Pseudobulbus Bletillae (Rhizoma Bletillae): pick decontamination, is soaked in water, and pulls out, runs through, section, dry;

(27) Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;

(28) Radix Rhapontici: pick clean impurity, unhairing is cleaned, and runs through, and section, dries;

(29) Rhizoma Corydalis: pick decontamination, is soaked in water, and clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;

(30) Concha Margaritifera: pick decontamination, knock fragment, sieve dedust bits;

(2) prepare

(1) by the Radix Astragali of described weight, Radix Scrophulariae, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Flos Lonicerae, Radix Pseudostellariae, Herba Leonuri, Radix Paeoniae Rubra, Radix Ophiopogonis, Radix Angelicae Sinensis, Caulis Spatholobi, the Rhizoma Anemarrhenae, Lumbricus, Lignum Sappan, Radix Trichosanthis, Herba Epimedii, Semen Coicis, Rhizoma Atractylodis, Cortex Moutan, Radix Gentianae, Flos Carthami, Herba Violae, Radix Aconiti Lateralis Preparata, Rhizoma Sparganii, Herba Eupatorii, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cimicifugae, Radix Rhapontici, Rhizoma Corydalis, Concha Margaritifera medicine decocts with water secondary, add water 8 times amount for the first time, soak after 120 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor, first time decoction liquor is poured in container,

(2) add water the medicinal residues of filtration 6 times amount, first boils with high heat, then use slow fire boiling 40 minutes, filters to obtain second time decoction liquor;

(3) twice decoction liquor is carried out mixing and stirring, be divided into 6 doses and take.