CN105342904B - A kind of Essence with skin wrinkle resisting effect - Google Patents
A kind of Essence with skin wrinkle resisting effect Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
A kind of Essence with skin wrinkle resisting effect, using cyperus alternifolius, roselle, gumbo, fullerene, hyaluronic acid as main composition, for influenceing an important factor for wrinkle of skin produces, such as ultraviolet, free radical, inflammation, MMPs, the Essence of crease-resistant effect is developed.Its each component has the function that Synergistic, has moisturizing, supplement extracellular matrix, resists ultraviolet, remove free radical, anti-inflammatory, suppress MMPs expression and other effects, to thicken extracellular matrix, reach crease-resistant effect.The present invention overcomes the shortcomings of the prior art, and preparation method is simple, is adapted to large-scale promotion, and long-term use has anti-wrinkle effect.
Description
Technical field
The invention belongs to the technical field of cosmetics, and in particular to Essence caused by a kind of delaying skin wrinkle.
Background technology
Wrinkle is one of mark of skin aging, after it is due to influence of the human body by endogenous and extrinsic factor,
Cause the change of skin support tissue and skin texture, cause the forfeiture of skin moisturizing ability, elastic fibers and collagen arrangement are suitable
The change of sequence, thus cause the mechanical force and flexibility decrease of skin, depression is formed, so as to form wrinkle.
Mechanism is sufficiently complex caused by wrinkle, and one of them is exactly that cell caused by each factor including ultraviolet damages
Wound and by the increased Apoptosis of the damage, protease such as matrix metalloproteinase (matrix metalloprotease,
MMPs) the hydrolysis of fibre composition such as collagen caused by the increase of expression, and fibre bundle watt caused by the increase of cell factor
Solution.Wherein MMPs plays critical effect in this process, and it has multiple functions, and such as degraded is by collagen, egg
Protein that the extracellular matrix of the formation such as white polysaccharide, elastin laminin and degraded are expressed on cell surface etc..And these are degraded
Effect causes the reduction and denaturation of extracellular matrix, is an important factor for skin forms wrinkle, relaxation etc..Further, since inflammation
The inflammatory cytokines such as TNF-α caused by cell, IL-1 and IL-6 are caused to cause wrinkle of skin by inducing MMPs generation
With loose formation.
And anti-wrinkle product in the market is single mainly for moisturizing and Green Tea Extract, function, do not produced in view of wrinkle
Raw composite factor, therefore good anti-wrinkle effect is not had, therefore exploitation of the people to new anti-wrinkle product has strongly
Demand.
The content of the invention
For the present invention is furture elucidated, the technical term used in present application is defined as follows, unless otherwise indicated.
Definition：
Extract：Refer to a kind of solution by soaking or being mixed in obtained in solvent the material to be extracted.Extraction
Process is taken to be carried out with the help of the suitable solvent of selection, such as：Water, ethanol, ethanol/water mixture, methanol, propyl alcohol, butanol,
Chloroform, acetone or other organic solvents, and by isolating, being percolated, decocting, counter-current extraction, ultrasonic wave, microwave, supercritical fluid
The method of extraction obtains extract, and extract can be further concentrated by evaporation, and obtains medicinal extract and the extract of drying.
Cyperus alternifolius extract：Extract to obtain as raw material using the leaf of cyperus alternifolius (Graptopetalum paraguayense),
Its functional component based on polyphenol, polysaccharide, anthocyanidin, flavone compound, separately containing multivitamin (vitamin C, B1, B2,
B6 etc.), mineral matter etc., have it is good prevent ultraviolet to the damaging of skin, anti-oxidant, anti-inflammatory, whitening effect.
Roselle flower extract：Using the calyx of malvaceae plant roselle (Hibiscus sabdariffa.L) as raw material
The obtained anthocyanin type components that are free of are extracted (such as delphinidin -3- elder bioside, corn flower -3- elder bioside, to fly
Swallow grass element -3- glucosides and die young Che Jusu -3- glucosides etc.) extract, the extract rich in polysaccharide, Polyphenols,
Flavonoid class, flavonoids, protocatechuic acid and other functional ingredient, additionally containing abundant amino acid, vitamin, have to uvioresistant
Damage, moisturizing, free radical is removed, suppresses MMPs enzymatic activitys, promote the effect such as cell growth and collagen secretion.
Gumbo extract：With Malvaceae herbaceous plant gumbo (Abelmoschus esculentus L.Moench) leaf
Extract to obtain extract for raw material, the extract removes isolating protein, polypeptide and Amino acids, mainly contains abundant flavones
Class, polysaccharide, polyphenol components, skin microcirculation can be promoted, promote the discharge of absorption and metabolin of the skin to nutritional ingredient,
Suppress MMPs enzymatic activity, have and mitigate cutis laxa, lifting is compacted, and goes the effect of wrinkle.
Fullerene：Fullerene (Fullerene) is that one kind is made up of carbon, and with spherical, ellipticity, or tubular structure are deposited
Material, it is referred to as " absorb free radical sponge ".Due to the hollow cage-shape structure of fullerene, special physics is made it have
And chemical property, such as catalytic activity, carrier function, bioactivity, there is Green Tea Extract, anti-oxidant, light in terms of cosmetics
Speckles, beautification and white is with suppressing inflammation and other effects.In addition, it also has obvious inhibitory action to MMPs, collagen, bullet can be protected
The property extracellular matrix such as albumen and laminin is not degraded.
Micromolecule hyaluronic acid：It is molecular weight in ＜ 10000Da hyaluronic acid, is easily inhaled because molecular weight is small by skin
Receive, and with whitening, moisturizing, crease-resistant and other effects.
The present invention provides cosmetic additive agent caused by a kind of new delaying skin wrinkle, to overcome existing for prior art
Defect.The purpose of the present invention is the mechanism formed from wrinkle of skin, from damage of the ultraviolet to skin is prevented, is removed harmful
Free radical, strengthen cell-proliferation activity, reconstruct extracellular matrix, reduce MMPs albuminoid enzymatic activitys prevent I, III, IV type etc.
The extracellular matrixs such as a variety of collagens, proteoglycan, elastin laminin and laminin are degraded, and reduce inflammatory factor pair
MMPs induced activity etc. considers, by cyperus alternifolius extract, Roselle flower extract, gumbo extract, fullerene and
Hyaluronic acid is compounded, and obtains the Essence with stronger anti-wrinkle effect.The respective effect of extract is not only given full play to, and
And the effect of Synergistic will be also produced, bring 1+1 ＞ 2 effect.
The technical scheme is that：
A kind of Essence with skin wrinkle resisting effect：
It is characterized in that：It is made up of following parts by weight of component：
Functional component：0.01~20 part of cyperus alternifolius extract, 0.01~20 part of Roselle flower extract, gumbo extract
0.001~10 part, fuller olefinic carbon 60 .0001~10 part, 0.1~20 part of micromolecule hyaluronic acid；
Carrier：0.1~10 part of 1,3-BDO, 1~10 part of glycerine, 0.05~0.5 part of Phenoxyethanol, deionized water 60~
90 parts.
The present invention develops a kind of new Essence with skin wrinkle resisting effect, and it is a variety of caused by wrinkle of skin
Mechanism is compounded, and compounding composition is innovated, and obtains the formula combination with synergistic function, and the combination resists
Wrinkle effect is much better than each single component sum in formula.Simple production process of the present invention, it is adapted to large-scale production, and product has
There is the features such as good, safe, the gentle effect of anti-wrinkle effect is comprehensive.
Embodiment
Following example is described in detail to the new method of the present invention, but is not intended to limit the scope of the present invention.
Embodiment 1：
A kind of Essence with skin wrinkle resisting effect, is made up of following parts by weight of component：
Functional component：10 parts of cyperus alternifolius extract, 5 parts of Roselle flower extract, 3 parts of gumbo extract, fuller olefinic carbon 60 .1
Part, 5 parts of micromolecule hyaluronic acid；
Carrier：3 parts of 1,3-BDO, 6 parts of glycerine, 0.5 part of Phenoxyethanol, 67.4 parts of deionized water；
By load weighted glycerine, 1,3-BDO, deionized water adds in kettle and is heated to 95 DEG C, after stirring and evenly mixing, and makes
With cooling water temperature to 70 DEG C, micromolecule hyaluronic acid is added while stirring, and stirring continues cool to 45 up to being completely dissolved
DEG C, functional component (cyperus alternifolius extract, Roselle flower extract, gumbo extract, fullerene and small molecule are added while stirring
Hyaluronic acid) and the composition such as Phenoxyethanol, until stir, it is filling to produce the Essence with crease-resistant effect.
Above-described embodiment preparation method is simple, and cost is cheap, is adapted to large-scale promotion, obtained anti-wrinkle essence, has
The features such as anti-wrinkle effect is good, safe, gentle, effect is comprehensive.
Embodiment 2：
A kind of Essence with skin wrinkle resisting effect, is made up of following parts by weight of component：
Functional component：5 parts of cyperus alternifolius extract, 2 parts of Roselle flower extract, 0.5 part of gumbo extract, fuller olefinic carbon 60 .1
Part, 7 parts of micromolecule hyaluronic acid；
Carrier：2 parts of 1,3-BDO, 5 parts of glycerine, 1 part of Phenoxyethanol, 77.4 parts of deionized water；
By load weighted glycerine, 1,3-BDO, deionized water adds in kettle and is heated to 95 DEG C, after stirring and evenly mixing, and makes
With cooling water temperature to 70 DEG C, micromolecule hyaluronic acid is added while stirring, and stirring continues cool to 45 up to being completely dissolved
DEG C, functional component (cyperus alternifolius extract, Roselle flower extract, gumbo extract, fullerene and small molecule are added while stirring
Hyaluronic acid) and the composition such as Phenoxyethanol, until stir, it is filling to produce the Essence with crease-resistant effect.
Above-described embodiment preparation method is simple, and cost is cheap, is adapted to large-scale promotion, obtained anti-wrinkle essence, has
The features such as anti-wrinkle effect is good, safe, gentle, effect is comprehensive.
Embodiment 3：
A kind of Essence with skin wrinkle resisting effect, is made up of following parts by weight of component：
Functional component：7 parts of cyperus alternifolius extract, 10 parts of Roselle flower extract, 1 part of gumbo extract, fuller olefinic carbon 60 .01
Part, 3 parts of micromolecule hyaluronic acid；
Carrier：1 part of 1,3-BDO, 7 parts of glycerine, 0.8 part of Phenoxyethanol, 70.19 parts of deionized water；
By load weighted glycerine, 1,3-BDO, deionized water adds in kettle and is heated to 95 DEG C, after stirring and evenly mixing, and makes
With cooling water temperature to 70 DEG C, micromolecule hyaluronic acid is added while stirring, and stirring continues cool to 45 up to being completely dissolved
DEG C, functional component (cyperus alternifolius extract, Roselle flower extract, gumbo extract, fullerene and small molecule are added while stirring
Hyaluronic acid) and the composition such as Phenoxyethanol, until stir, it is filling to produce the Essence with crease-resistant effect.
Above-described embodiment preparation method is simple, and cost is cheap, is adapted to large-scale promotion, obtained anti-wrinkle essence, has
The features such as anti-wrinkle effect is good, safe, gentle, effect is comprehensive.
Embodiment 4：
A kind of Essence with skin wrinkle resisting effect, is made up of following parts by weight of component：
Functional component：15 parts of cyperus alternifolius extract, 0.5 part of Roselle flower extract, 0.5 part of gumbo extract, fullerene
0.05 part, 6 parts of micromolecule hyaluronic acid；
Carrier：2 parts of 1,3-BDO, 3 parts of glycerine, 0.5 part of Phenoxyethanol, 72.45 parts of deionized water；
By load weighted glycerine, 1,3-BDO, deionized water adds in kettle and is heated to 95 DEG C, after stirring and evenly mixing, and makes
With cooling water temperature to 70 DEG C, micromolecule hyaluronic acid is added while stirring, and stirring continues cool to 45 up to being completely dissolved
DEG C, functional component (cyperus alternifolius extract, Roselle flower extract, gumbo extract, fullerene and small molecule are added while stirring
Hyaluronic acid) and the composition such as Phenoxyethanol, until stir, it is filling to produce the Essence with crease-resistant effect.
Above-described embodiment preparation method is simple, and cost is cheap, is adapted to large-scale promotion, obtained anti-wrinkle essence, has
The features such as anti-wrinkle effect is good, safe, gentle, effect is comprehensive.
Embodiment 5：
A kind of Essence with skin wrinkle resisting effect, is made up of following parts by weight of component：
Functional component：0.1 part of cyperus alternifolius extract, 10 parts of Roselle flower extract, 5 parts of gumbo extract, fuller olefinic carbon 60 .5
Part, 2 parts of micromolecule hyaluronic acid；
Carrier：3 parts of 1,3-BDO, 3 parts of glycerine, 1 part of Phenoxyethanol, 75.4 parts of deionized water；
By load weighted glycerine, 1,3-BDO, deionized water adds in kettle and is heated to 95 DEG C, after stirring and evenly mixing, and makes
With cooling water temperature to 70 DEG C, micromolecule hyaluronic acid is added while stirring, and stirring continues cool to 45 up to being completely dissolved
DEG C, functional component (cyperus alternifolius extract, Roselle flower extract, gumbo extract, fullerene and small molecule are added while stirring
Hyaluronic acid) and the composition such as Phenoxyethanol, until stir, it is filling to produce the Essence with crease-resistant effect.
Above-described embodiment preparation method is simple, and cost is cheap, is adapted to large-scale promotion, obtained anti-wrinkle essence, has
The features such as anti-wrinkle effect is good, safe, gentle, effect is comprehensive.
To determine anti-wrinkle essence of the present invention following experimental study has been carried out in the effect of crease-resistant aspect：
1st, to the inhibiting rate of MMP-1 expression
Prepare respectively containing 5% cyperus alternifolius extract, 2% roselle extract, 0.5% gumbo extract,
0.1% fullerene, the Essence of 7% micromolecule hyaluronic acid (using deionized water prepared, and is wherein contained by these Essences
Have 2%1,3- butanediols, 5% glycerine, 1% Phenoxyethanol) essence of (above percentage is calculated in parts by weight) and embodiment 2
Magnificent liquid, the anti-wrinkle effect of these samples is assessed by testing these samples to MMP-1 inhibiting rate.
Fibroblast is inoculated into 12 porocyte culture plates, each hole contains 0.75 × 105Individual cell, and in nothing
Hungry culture 24 hours in blood serum medium.The cell through starvation culture is rinsed with PBS, and with treatment with ultraviolet light (40mJ).
Then, in 48 hours, test sample is added into cell 2 times.Measured with kit (BIOTRAK, RPN2610) in culture medium
The MMP-1 of separation.The power of crease-resistant effect is assessed by calculating MMP-1 expression inhibiting rate.Calculation formula is as follows：
Inhibiting rate=(A-B)/A*100%
A:Be not added with test sample, but after ultraviolet irradiation MMP-1 expression quantity
B:Add test sample and after ultraviolet irradiation MMP-1 expression quantity
As a result shown in table 1.
The inhibiting rate that 1 different test samples of table are expressed MMP-1
As can be seen from the above table, the inhibiting rate that 6 kinds of testing samples are expressed MMP-1 is different, but the sample pair of embodiment 2
The suppression of MMP-1 expression is apparently higher than other 5 testing samples, and under 10 μ g/ml concentration, inhibiting rate reaches 82.4% for it,
The significantly larger than inhibiting rate sum of inhibiting rate and this 5 kind Essences of other 5 kinds of Essences under 50 μ g/ml concentration, explanation
Embodiment 2 has significant inhibitory action to MMP-1 expression, and wherein each component has good syneryistic effect.
2nd, the synthesis promotion rate of III collagen type：
The human fibroblasts cultivated in the DMEM culture mediums containing 10%FBS are seeded in 24 orifice plates, after cell attachment,
Culture medium exchange is carried out with the DMEM culture mediums containing 0.25%FBS and 250 μM of magnesium ascorbyl phosphate, is separately added into above-mentioned 6
Kind testing sample.After culture three days, culture medium supernatant is reclaimed, is centrifuged, III collagen type in measure gained supernatant.
Evaluation method on the biosynthesis ability of III collagen type in cell is to use " P (the P of RIA-gnost P III
III P) measure kit " measure supernatant in secrete III collagen type terminal peptide (Procollagen type III-
peptide：The referred to as P of P III) content.The crease-resistant of these samples is assessed by the synthesis promotion rate of III collagen type
The power of effect.Calculation formula is as follows：
Promotion rate=(A-B)/B*100%
A:Add III collagen type growing amount after test sample
B:It is not added with III collagen type growing amount of test sample
It the results are shown in Table 2:
Synthesis promotion rate of the 2 different test samples of table to III collagen type
| Test sample | Concentration (μ g/ml) | Promotion rate (%) |
| 5% cyperus alternifolius extract essence liquid | 10 | 11.5 |
| 2% roselle extract essence liquid | 10 | 9.1 |
| 0.5% gumbo extract essence liquid | 10 | 12.1 |
| 0.1% fullerene Essence | 10 | 15.3 |
| 7% micromolecule hyaluronic acid Essence | 10 | 4.7 |
| Embodiment 2 | 10 | 168.2 |
As can be seen from the above table, the Essence of various single functional components is respectively provided with necessarily to III collagen type growing amount
Promotion it is active but all relatively low, be below 20% at the concentration tested.If add up to the rush of five kinds of each single functional component Essences
If entering rate, its promotion rate is 52.3%, and the promotion rate of embodiment 2 is 168.2%, about the former 3.2 times, this explanation,
After compounding, composition acts synergistically the effect of in three kinds of extracts, mutually enhancing, promotes cell to III collagen type
Secretion, improve III collagen type growing amount, thicken extracellular matrix, and then realize anti-wrinkle effect.
Claims (1)
- A kind of 1. Essence with skin wrinkle resisting effect, it is characterised in that：It is made up of following parts by weight of component：Functional component：0.01~20 part of cyperus alternifolius extract, 0.01~20 part of Roselle flower extract, gumbo extract 0.001 ~10 parts, fuller olefinic carbon 60 .0001~10 part, 0.1~20 part of micromolecule hyaluronic acid；Carrier：0.1~10 part of 1,3-BDO, 1~10 part of glycerine, 0.05~0.5 part of Phenoxyethanol, deionized water 60~90 Part.
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