KR102309956B1 - Composition for improving the skin blood flow containing chamomile flower powder - Google Patents
Composition for improving the skin blood flow containing chamomile flower powder Download PDFInfo
- Publication number
- KR102309956B1 KR102309956B1 KR1020140129136A KR20140129136A KR102309956B1 KR 102309956 B1 KR102309956 B1 KR 102309956B1 KR 1020140129136 A KR1020140129136 A KR 1020140129136A KR 20140129136 A KR20140129136 A KR 20140129136A KR 102309956 B1 KR102309956 B1 KR 102309956B1
- Authority
- KR
- South Korea
- Prior art keywords
- chamomile
- flower powder
- skin
- composition
- extract
- Prior art date
Links
- 235000007866 Chamaemelum nobile Nutrition 0.000 title claims abstract description 98
- 235000007232 Matricaria chamomilla Nutrition 0.000 title claims abstract description 95
- 239000000203 mixture Substances 0.000 title claims abstract description 77
- 239000000843 powder Substances 0.000 title claims abstract description 71
- 230000008326 skin blood flow Effects 0.000 title claims abstract description 33
- 240000003538 Chamaemelum nobile Species 0.000 title abstract description 9
- 239000002537 cosmetic Substances 0.000 claims abstract description 23
- 229940079593 drug Drugs 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 12
- 244000042664 Matricaria chamomilla Species 0.000 claims description 104
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 65
- 235000011187 glycerol Nutrition 0.000 claims description 32
- 235000020221 chamomile extract Nutrition 0.000 claims description 29
- 229940119217 chamomile extract Drugs 0.000 claims description 29
- 239000000284 extract Substances 0.000 claims description 22
- 235000004429 Matricaria chamomilla var recutita Nutrition 0.000 claims description 11
- 229940098465 tincture Drugs 0.000 claims description 6
- 229940070641 chamomile flowers Drugs 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 238000007602 hot air drying Methods 0.000 claims description 2
- 235000013305 food Nutrition 0.000 abstract description 16
- 210000003491 skin Anatomy 0.000 description 33
- 230000000694 effects Effects 0.000 description 30
- 230000006872 improvement Effects 0.000 description 28
- 230000017531 blood circulation Effects 0.000 description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 20
- 230000000052 comparative effect Effects 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- 239000002904 solvent Substances 0.000 description 14
- 235000019441 ethanol Nutrition 0.000 description 12
- 238000009472 formulation Methods 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
- 238000000605 extraction Methods 0.000 description 10
- -1 pack Substances 0.000 description 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- 230000036541 health Effects 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000008213 purified water Substances 0.000 description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 6
- 235000013355 food flavoring agent Nutrition 0.000 description 6
- 235000013376 functional food Nutrition 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000006071 cream Substances 0.000 description 5
- 235000015872 dietary supplement Nutrition 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 238000005194 fractionation Methods 0.000 description 5
- 230000007794 irritation Effects 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 235000013361 beverage Nutrition 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 240000008632 Cota tinctoria Species 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 235000017945 Matricaria Nutrition 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 230000010412 perfusion Effects 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 239000000344 soap Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 235000012222 talc Nutrition 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
- 239000008158 vegetable oil Substances 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 229930091371 Fructose Natural products 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 208000003351 Melanosis Diseases 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 244000299461 Theobroma cacao Species 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000000378 calcium silicate Substances 0.000 description 2
- 229910052918 calcium silicate Inorganic materials 0.000 description 2
- 235000012241 calcium silicate Nutrition 0.000 description 2
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000036074 healthy skin Effects 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 239000012264 purified product Substances 0.000 description 2
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- ZAUYNCUCMJDAHW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;hydrogen peroxide;molecular iodine Chemical compound OO.II.C=CN1CCCC1=O ZAUYNCUCMJDAHW-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- GFVYDNHWTCHDSN-UHFFFAOYSA-N 14-methylpentadecyl octanoate Chemical compound CCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C GFVYDNHWTCHDSN-UHFFFAOYSA-N 0.000 description 1
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical class CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- MTJGVAJYTOXFJH-UHFFFAOYSA-N 3-aminonaphthalene-1,5-disulfonic acid Chemical compound C1=CC=C(S(O)(=O)=O)C2=CC(N)=CC(S(O)(=O)=O)=C21 MTJGVAJYTOXFJH-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 235000006491 Acacia senegal Nutrition 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- 206010008570 Chloasma Diseases 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 239000001512 FEMA 4601 Substances 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 208000001034 Frostbite Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 244000228451 Stevia rebaudiana Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000013040 bath agent Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 210000001736 capillary Anatomy 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005206 flow analysis Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- LCLHHZYHLXDRQG-ZNKJPWOQSA-N pectic acid Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)O[C@H](C(O)=O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](OC2[C@@H]([C@@H](O)[C@@H](O)[C@H](O2)C(O)=O)O)[C@@H](C(O)=O)O1 LCLHHZYHLXDRQG-ZNKJPWOQSA-N 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 235000013550 pizza Nutrition 0.000 description 1
- 238000004161 plant tissue culture Methods 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 239000010318 polygalacturonic acid Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 235000019203 rebaudioside A Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000008234 soft water Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
본 발명은 카모마일 꽃 분말을 포함하는 피부 혈행 개선용 화장료 조성물, 의약외품 조성물 및 식품 조성물에 관한 것이다. The present invention relates to a cosmetic composition for improving skin blood circulation, a quasi-drug composition, and a food composition comprising chamomile flower powder.
Description
본 발명은 카모마일 꽃 분말을 포함하는 피부 혈행 개선용 화장료 조성물, 의약외품 조성물 및 식품 조성물에 관한 것이다.
The present invention relates to a cosmetic composition for improving skin blood circulation, a quasi-drug composition, and a food composition comprising chamomile flower powder.
피부는 외부 환경으로부터 우리 몸을 보호하기 위해 매우 중요한 역할을 담당하고 있으며, 인간의 아름다움을 나타낼 수 있는 기관이다. 사람들은 깨끗하고 건강한 피부, 백옥같이 하얗고 생기있는 피부를 소유하기를 원한다. 그러나, 우리의 피부는 나이가 들어감에 따라 또는 출산을 경험하면서 어혈이 쉽게 생기고 혈액순환장애를 겪게 된다. 이로 인해 신진대사능력이 저하되어 피부 탄력이 감소되고 쉽게 거칠어질 뿐 아니라 피부타입이 변하기도 한다. The skin plays a very important role in protecting our body from the external environment, and is an organ that can represent human beauty. People want to have clean and healthy skin, white and lively skin like white jade. However, as our skin ages or undergoes childbirth, eohyeol easily forms and blood circulation is impaired. Due to this, the metabolic ability is lowered, the skin elasticity is reduced, and the skin type is changed as well as the skin becomes rough easily.
외적으로도 오존층이 파괴되어 지표에 도달하는 자외선의 함량이 증가하고 환경 오염이 심화되어 자유 라디칼 및 유해 활성 산소 등이 증가함으로써, 피부 두께가 감소하고, 주름이 증가되고, 탄력이 감소될 뿐 아니라 기미, 주근깨 및 검버섯 또한 증가하는 등 여러 가지 변화를 일으키게 된다.Externally, as the ozone layer is destroyed, the content of ultraviolet rays reaching the surface increases, and environmental pollution deepens, resulting in an increase in free radicals and harmful active oxygen. Melasma, freckles, and age spots also increase, causing various changes.
또한, 최근 햇볕에 의한 피부 노화는 모세혈관의 감소가 주원인이라는 연구결과가 제기되었다. 특히, 모세혈관이 줄어든 부위가 피부 손상이 심하게 일어난 표피 바로 아래의 진피 위쪽에 집중돼 있어 피부 노화와 밀접한 관련이 있음을 시사했다. 더불어 햇볕에 장시간 노출된 피부는 모세혈관의 크기와 숫자가 감소하여 피부에 각종 영양분과 산소를 운반하는 기능이 떨어지고, 피부에 탄력성을 주는 물질들이 재생되지 않아 주름 등을 유발하는 원인이 된다는 사실도 확인되었다. In addition, recent research results have been raised that the reduction of capillaries is the main cause of skin aging due to sunlight. In particular, the area with reduced capillaries was concentrated in the upper dermis just below the epidermis where the skin damage occurred, suggesting that it is closely related to skin aging. In addition, the fact that skin exposed to the sun for a long time decreases the size and number of capillaries, which reduces the ability to transport various nutrients and oxygen to the skin, and the substances that give elasticity to the skin do not regenerate, which causes wrinkles. Confirmed.
따라서, 피부 혈류량 개선은 피부의 원활한 혈류량 개선을 통해 칙칙하고 탄력 없는 피부를 생동력 있고 맑고 투명한 피부로 만들어 주어 외관상 돋보이는 건강한 피부를 만들어 줄 수 있다.
Therefore, skin blood flow improvement can make dull and inelastic skin lively, clear and transparent skin through smooth blood flow improvement of the skin, thereby making healthy skin that stands out in appearance.
그러나 혈류량 증가 등 혈행 개선 효능을 가진 물질은 극히 제한적이거나 효능을 가진 물질도 많이 알려져 있지 않으며 현재 사용되는 소수의 물질도 화학적으로 합성하여 사용하고 있어, 피부 적용에 보다 안전한 화장료에 대한 요구가 증가하고 있는 실정이다.
However, substances with blood circulation improvement effects such as increased blood flow are extremely limited, or substances with efficacy are not widely known, and a small number of substances currently used are chemically synthesized and used. there is a situation.
이러한 배경하에, 본 발명자들은 천연에 존재하는 천연 자원들로부터 독성이 없고 피부 상태 개선 효과가 우수한 물질에 관하여 연구를 수행하였으며, 이에 카모마일 꽃 분말이 혈류량 증가 및 혈류 개선에 대해 우수한 효과를 나타냄을 규명하여, 이를 활용한 피부 혈행 개선용 조성물을 완성하기에 이르렀다.
Under this background, the present inventors conducted research on a substance that is non-toxic and has an excellent skin condition improvement effect from natural resources, and found that chamomile flower powder exhibits an excellent effect on blood flow increase and blood flow improvement. Thus, a composition for improving skin blood circulation using this was completed.
본 발명의 목적은 카모마일 꽃 분말을 포함하는, 피부 혈행 개선용 화장료 조성물 제공하는 것이다.An object of the present invention is to provide a cosmetic composition for improving skin blood circulation, comprising chamomile flower powder.
본 발명의 다른 목적은 카모마일 꽃 분말을 포함하는, 피부 혈행 개선용 의약외품 조성물을 제공하는 것이다.Another object of the present invention is to provide a quasi-drug composition for improving skin blood circulation, comprising chamomile flower powder.
본 발명의 또 다른 목적은 카모마일 꽃 분말을 포함하는, 피부 혈행 개선용 식품 조성물을 제공하는 것이다.
Another object of the present invention is to provide a food composition for improving skin blood circulation, comprising chamomile flower powder.
상기 과제를 해결하기 위하여, 본 발명의 일 구현예로서, 카모마일 꽃 분말을 포함하는, 피부 혈행 개선용 화장료 조성물을 제공한다.
In order to solve the above problems, as an embodiment of the present invention, there is provided a cosmetic composition for improving skin blood circulation, comprising chamomile flower powder.
본 발명에서, "카모마일(Chamomile)"은 쌍떡잎식물 초롱꽃목 국화과의 풀을 의미하는 것으로, 주로 저먼 카모마일과 로만 카모마일이 알려져 있다. 카모마일은 불면증, 구강염, 인후염의 소염제, 소화계통에 항염작용과 발한작용, 신경통 류마티스, 강장작용, 습진, 여드름 등에 효과가 있다고 알려져 있으며, 한방에서는 염증, 방부, 구충, 경련을 가라앉히는데 사용되고 있다. In the present invention, "chamomile (Chamomile)" refers to the grass of the dicotyledonous plant, Camphoraceae, Asteraceae, mainly German chamomile and Roman chamomile are known. Chamomile is known to be effective against insomnia, stomatitis, sore throat, anti-inflammatory and sweating action on the digestive system, neuralgia, rheumatism, tonicity, eczema, and acne. .
본 발명에서 카모마일은 종류에 관계없이 적용될 수 있으며, 그 예로 저먼 카모마일(German Chamomile:Matricaria recutica)과 로만 카모마일(Roman Chamomile :Anthemis nobilis), 보데골드 카모마일(Bodegold Chamomile), 다이어스 카모마일(Dyer's Chamomile) 등을 사용할 수 있다.In the present invention, chamomile may be applied regardless of type, for example, German Chamomile ( Matricaria recutica ) and Roman Chamomile (Roman Chamomile: Anthemis nobilis ), Bodegold Chamomile (Bodegold Chamomile), Dyer's Chamomile (Dyer's Chamomile) etc. can be used.
구체적으로, 상기 카모마일 꽃 분말은 카모마일의 종류에 관계없이 카모마일 꽃 유래의 분말이면 모두 사용될 수 있으며, 이에 제한되지는 않으나 저먼(German) 카모마일 꽃(INCI명: Chamomilla Recutita (Matricaria) Flower), 로만(Roman) 카모마일 꽃(INCI명: Anthemis Nobilis Flower) 분말을 사용할 수 있다. 더욱 구체적으로는 저먼 카모마일 꽃 유래의 분말을 사용할 수 있다.
Specifically, the chamomile flower powder may be used as long as it is a chamomile flower-derived powder regardless of the type of chamomile, but is not limited thereto, but German chamomile flower (INCI name: Chamomilla Recutita (Matricaria) Flower), Roman ( Roman) chamomile flower (INCI name: Anthemis Nobilis Flower) powder can be used. More specifically, powder derived from German chamomile flowers may be used.
본 발명에서, “혈행” 이란 체내 혈액의 흐름을 말하며, 동맥과 정맥, 모세혈관의 혈류에 생기는 장애를 혈행 장애라 한다. 혈행 장애가 생길 경우, 피부나 근육 등으로 전달되는 혈액의 양이 감소되어 손발이 저리거나 시리고 통증, 어지럼증, 동상 등이 나타날 수 있으며, 피부가 창백해지거나 피부색깔 및 피부온도의 변화가 생겨 생기가 떨어지고 노폐물 교환이 원활하지 않게 되어 피부노화가 급격히 진행될 수 있다.
In the present invention, "blood circulation" refers to the flow of blood in the body, and disorders occurring in the blood flow of arteries, veins, and capillaries are called blood circulation disorders. In the case of a blood circulation disorder, the amount of blood delivered to the skin or muscles is reduced, which may cause numbness, tingling, pain, dizziness, frostbite, etc. This can lead to rapid skin aging due to poor exchange of waste products.
본 발명의 일 실시예에 의하면, 상기 본 발명의 카모마일 꽃 분말을 함유하는 조성물을 20~40대 여성 25명에게 10분 동안 얼굴 전체에 도포하게 하고 피부 혈류량 및 생기 개선 정도를 분석하였다. 그 결과, 카모마일 꽃 분말만을 유효성분으로 포함하고 있는 실시예 1의 경우 피부 혈류량이 48.39% 증가하였으며, 피부 생기는 76% 개선되는 것을 확인하였다. According to one embodiment of the present invention, the composition containing the chamomile flower powder of the present invention was applied to 25 women in their 20s to 40s on the entire face for 10 minutes, and the degree of improvement in skin blood flow and vitality was analyzed. As a result, in the case of Example 1 containing only chamomile flower powder as an active ingredient, it was confirmed that the skin blood flow was increased by 48.39%, and the skin formation was improved by 76%.
또한, 상기 카모마일 꽃 분말을 포함하는 조성물의 피부 안전성을 확인하기 위하여, 상기 조성물을 건강한 성인남녀 25명을 대상으로 등부위에 각 시료의 일정량(0.2g)을 24시간 첩포한 후, 육안으로 피부상태 변화를 관찰하였다. 그 결과, 카모마일 꽃 분말만을 유효성분으로 포함하고 있는 실시예 1의 경우 피부에 어떠한 자극, 예컨대 홍반이나 부종 등을 보이지 않았으며, 자극도가 0.00인 것을 확인하였다. 따라서, 본 발명의 카모마일 꽃 분말을 포함하는 조성물은 피부에 자극 없이 피부 혈류량 개선 또는 피부 생기 개선용 화장료 조성물로 유용하게 이용될 수 있음을 확인하였다.
In addition, in order to confirm the skin safety of the composition containing the chamomile flower powder, a predetermined amount (0.2 g) of each sample was applied to the back of 25 healthy adult men and women for 24 hours, and then the skin condition with the naked eye. Changes were observed. As a result, in the case of Example 1 containing only chamomile flower powder as an active ingredient, there was no irritation to the skin, such as erythema or edema, and it was confirmed that the irritation level was 0.00. Therefore, it was confirmed that the composition comprising the chamomile flower powder of the present invention can be usefully used as a cosmetic composition for improving skin blood flow or improving skin vitality without irritation to the skin.
본 발명의 구체적인 일 구현예로, 상기 카모마일 꽃 분말은 전체 조성물 100중량%에 대하여 0.0001 내지 2중량% 포함될 수 있다. 카모마일 꽃 분말의 함량이 0.0001중량% 미만인 경우, 혈행 개선 효과 및 피부 생기 개선효과가 미약한 문제가 생길 수 있으며, 2중량%를 초과할 경우, 분말의 이물감이 많이 느껴지고 외관상 좋지 못한 문제점이 발생할 수 있다.
In a specific embodiment of the present invention, the chamomile flower powder may be included in an amount of 0.0001 to 2% by weight based on 100% by weight of the total composition. If the content of chamomile flower powder is less than 0.0001% by weight, there may be a problem that the blood circulation improvement effect and skin vitality improvement effect are weak. have.
또 다른 구체적인 일 구현예로서, 상기 카모마일 꽃 분말은 카모마일 꽃을 열풍건조 후 분쇄하여 얻은 것일 수 있다. 본 발명 일 실시예에서는 이집트산 유기농 저먼 카모마일 100g을 정제수 1ℓ에 첨가하여 60℃ 이상에서 3시간 가열 후, 100 Mesh portable Filter를 사용하여 자연 낙하로 카모마일 꽃잎만을 걸러내고, 2~3회 정제수로 헹궈준 다음 남겨진 카모마일 꽃잎을 2~5일간 열풍건조 후 분쇄하여 얻은 카모마일 꽃 분말을 사용하였다.
As another specific embodiment, the chamomile flower powder may be obtained by pulverizing chamomile flowers after hot air drying. In one embodiment of the present invention, 100 g of Egyptian organic German chamomile is added to 1 liter of purified water, heated at 60° C. or higher for 3 hours, and then only the chamomile petals are filtered by natural fall using a 100 Mesh portable filter, and rinsed with purified water 2-3 times. Chamomile flower powder obtained by pulverizing the remaining chamomile petals after drying with hot air for 2 to 5 days was used.
또한 구체적으로, 본 발명의 피부 혈행 개선용 화장료 조성물은 카모마일 추출물, 이의 분획물 또는 글리세린 중 하나 이상을 추가로 포함할 수 있다. 글리세린은 시중에서 통상적으로 사용되는 글리세린을 사용할 수 있다.
In addition, specifically, the cosmetic composition for improving skin blood circulation of the present invention may further include one or more of a chamomile extract, a fraction thereof, or glycerin. As the glycerin, glycerin commonly used in the market may be used.
본 발명 일 실시예에서는 카모마일 꽃 분말에 글리세린이 더욱 포함된 실시예 2, 카모마일 추출물이 더욱 포함된 실시예 3, 글리세린 및 카모마일 추출물이 더욱 포함된 실시예 4 조성물 각각에 대하여 피부 혈류량 및 생기 개선 정도를 분석하였다. 그 결과, 카모마일 꽃 분말만을 유효성분으로 포함한 실시예 1 조성물에 비해 혈류량 증가율 및 생기 효과가 증가한 것을 확인할 수 있었다. In one embodiment of the present invention, the degree of improvement in skin blood flow and vitality for each composition in Example 2, in which chamomile flower powder further contains glycerin, in Example 3 in which chamomile extract is further included, and in Example 4 in which glycerin and chamomile extract are further included. was analyzed. As a result, it was confirmed that the blood flow increase rate and vitality effect were increased compared to the composition of Example 1 including only chamomile flower powder as an active ingredient.
특히, 카모마일 꽃 분말, 카모마일 추출물 및 글리세린을 모두 포함하는 조성물의 경우 혈류량 증가율이 79.35% 증가하고, 피부 생기가 96% 개선되는 효과를 나타내어, 피부 혈행 개선에 있어서 매우 우수한 효과를 나타내는 것을 확인하였다(도 1 및 도 2).
In particular, in the case of the composition containing all of chamomile flower powder, chamomile extract and glycerin, the blood flow increase rate increased by 79.35% and skin vitality was improved by 96%, indicating a very excellent effect in improving skin blood circulation ( 1 and 2).
본 발명에서 사용되는 용어, "카모마일 추출물"은 카모마일의 추출처리에 의하여 얻어지는 추출액, 상기 추출액의 희석액이나 농축액, 상기 추출액을 건조하여 얻어지는 건조물, 상기 추출액의 조정제물이나 정제물, 또는 이들의 혼합물 등, 추출액 자체 및 추출액을 이용하여 형성 가능한 모든 제형의 추출물을 포함할 수 있으며, 카모마일의 천연, 잡종 또는 변종 식물로부터 추출될 수 있고, 식물 조직 배양물로부터도 추출이 가능하다. 구체적으로는 상기 카모마일 추출물은 카모마일의 종류에 관계없이 추출하여 얻을 수 있으며, 그 예로 저먼 카모마일(German Chamomile:Matricaria recutica)과 로만 카모마일(Roman Chamomile :Anthemis nobilis), 보데골드 카모마일(Bodegold Chamomile), 다이어스 카모마일(Dyer's Chamomile) 등을 사용할 수 있다. 더욱 구체적으로는 저먼 카모마일을 추출하여 얻은 추출물일 수 있다.
As used herein, the term "chamomile extract" refers to an extract obtained by extracting chamomile, a diluted or concentrated liquid of the extract, a dried product obtained by drying the extract, a prepared or purified product of the extract, or a mixture thereof, etc. , the extract itself and extracts of all formulations that can be formed using the extract, may be extracted from natural, hybrid or variegated plants of chamomile, and may also be extracted from plant tissue culture. Specifically, the chamomile extract can be obtained by extraction regardless of the type of chamomile, for example, German Chamomile ( Matricaria recutica ), Roman Chamomile ( Anthemis nobilis ), Bodegold Chamomile, Dai You can use Dyer's Chamomile or the like. More specifically, it may be an extract obtained by extracting German chamomile.
본 발명의 상기 카모마일의 추출에 있어서, 상기 추출물을 추출하는 방법은 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용하는 방법에 따라 추출할 수 있다. 상기 추출 방법의 비제한적인 예로는, 열수 추출법, 초음파 추출법, 여과법, 환류 추출법 등을 들 수 있으며, 이들은 단독으로 수행되거나 2 종 이상의 방법을 병용하여 수행될 수 있다. 구체적으로 카모마일 추출물은 카모마일 팅쳐 추출물일 수 있으며, 이에 제한되지는 않으나 1차 추출용매 100 중량% 대비 0.2 중량% 내지 2.0 중량%의 건조된 카모마일 꽃을 상기 1차 추출용매에 넣고 20℃ 내지 30℃의 온도에서 24시간 내지 96시간 동안 침지하여 카모마일 꽃 침지물을 제조하는 단계(단계 1); 및 상기 카모마일 꽃 침지물에 2차 추출용매를 첨가하고 혼합 한 후 여과하는 단계(단계 2)를 포함하는, 카모마일 꽃 팅쳐 추출물의 제조방법에 의해 제조된 것일 수 있다. 더욱 구체적으로는 저먼 카모마일의 팅쳐 추출물일 수 있다.
In the extraction of the chamomile of the present invention, the method of extracting the extract is not particularly limited, and may be extracted according to a method commonly used in the art. Non-limiting examples of the extraction method include hot water extraction, ultrasonic extraction, filtration, reflux extraction, and the like, and these may be performed alone or in combination of two or more methods. Specifically, the chamomile extract may be a chamomile tincture extract, but is not limited thereto, but 0.2% to 2.0% by weight of dried chamomile flowers compared to 100% by weight of the primary extraction solvent is put in the primary extraction solvent and 20°C to 30°C Preparing a chamomile flower dip by immersing it for 24 hours to 96 hours at a temperature of (step 1); And it may be prepared by the method for producing a tincture extract of chamomile flowers, comprising the step of adding and mixing a secondary extraction solvent to the chamomile flower immersion water and filtering (step 2). More specifically, it may be a tincture extract of German chamomile.
본 발명에서 사용되는 용어 "팅쳐 추출물(Tincture Extract)"은, 카모마일을 에탄올 또는 에탄올과 물의 혼합액에 일정시간 침지한 후 짜내고 침출액을 증발시켜 농축한 제제를 의미하는 것으로, 이제 제한되지는 않으나, 추출처리에 의해 얻어지는 추출액, 추출액의 희석액 또는 농축액, 추출액을 건조하여 얻어지는 건조물, 이들의 조정제물 또는 정제물일 수 있다.
The term "tincture extract" used in the present invention refers to a preparation concentrated by immersing chamomile in ethanol or a mixture of ethanol and water for a certain period of time, squeezing it, and evaporating the leachate. It may be an extract obtained by treatment, a diluted or concentrated liquid of the extract, a dried product obtained by drying the extract, and a crude or purified product thereof.
또한, 본 발명에서 카모마일을 추출처리시 사용되는 추출용매의 종류는 특별히 제한되지 아니하며, 당해 기술 분야에서 공지된 임의의 용매를 사용할 수 있다. 상기 추출 용매의 비제한적인 예로는 물; 메탄올, 에탄올, 프로필알코올, 부틸알코올 등의 C1 내지 C4의 저급 알코올; 글리세린, 부틸렌글리콜, 프로필렌글리콜 등의 다가 알코올; 및 메틸아세테이트, 에틸아세테이트, 아세톤, 벤젠, 헥산, 디에틸에테르, 디클로로메탄 등의 탄화수소계 용매; 또는 이들의 혼합물을 사용할 수 있다. 본 발명에서 열수 추출 또는 냉침 추출한 추출물은 부유하는 고체 입자를 제거하기 위해 여과, 예를 들어 나일론 등을 이용해 입자를 걸러내거나 냉동여과법 등을 이용해 여과한 후, 그대로 사용하거나 이를 동결건조, 열풍건조, 분무건조 등을 이용해 건조시켜 사용할 수 있다.
In addition, the type of the extraction solvent used in the extraction treatment of chamomile in the present invention is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the extraction solvent include water; C 1 to C 4 lower alcohols such as methanol, ethanol, propyl alcohol, and butyl alcohol; polyhydric alcohols such as glycerin, butylene glycol and propylene glycol; and hydrocarbon solvents such as methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, and dichloromethane; Or a mixture thereof may be used. In the present invention, the extract extracted with hot water or chilled extract is filtered to remove floating solid particles, for example, using nylon or the like to filter the particles, or after filtration using a freeze filtration method, etc. It can be used by drying it using spray drying or the like.
본 발명에서 사용되는 용어, "분획물"은 여러 다양한 구성 성분들을 포함하는 혼합물로부터 특정 성분 또는 특정 성분 그룹을 분리하기 위하여 분획을 수행하여 얻어진 결과물을 의미한다.As used herein, the term "fraction" refers to a result obtained by performing fractionation in order to separate a specific component or a specific component group from a mixture including various components.
본 발명에서 상기 분획물을 얻는 분획 방법은 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용하는 방법에 따라 수행될 수 있다. 상기 분획 방법의 비제한적인 예로는, 카모마일을 추출하여 얻은 추출물에 소정의 용매를 처리하여 상기 추출물로부터 분획물을 얻는 방법을 들 수 있다.The fractionation method for obtaining the fraction in the present invention is not particularly limited, and may be performed according to a method commonly used in the art. Non-limiting examples of the fractionation method include a method of obtaining a fraction from the extract by treating an extract obtained by extracting chamomile with a predetermined solvent.
본 발명에서 상기 분획물을 얻는 데에 사용되는 용매의 종류는 특별히 제한되지 아니하며, 당해 기술 분야에서 공지된 임의의 용매를 사용할 수 있다. 상기 분획 용매의 비제한적인 예로는 물, 알코올 등의 극성 용매; 헥산(Hexane), 에틸 아세테이트(Ethyl acetate), 클로로포름(Chloroform), 디클로로메탄 (Dichloromethane) 등의 비극성 용매 등을 들 수 있다. 이들은 단독으로 사용되거나 2종 이상 혼합하여 사용될 수 있다. 상기 분획 용매 중 알코올을 사용하는 경우에는 구체적으로는 C1 내지 C4의 알코올을 사용할 수 있다.
The kind of solvent used to obtain the fraction in the present invention is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the fractionation solvent include polar solvents such as water and alcohol; and non-polar solvents such as hexane, ethyl acetate, chloroform, and dichloromethane. These may be used alone or in combination of two or more. In the case of using alcohol in the fractionation solvent, specifically C 1 to C 4 alcohol may be used.
본 발명의 화장료 조성물은 용액, 외용 연고, 크림, 폼, 영양 화장수, 유연 화장수, 팩, 유연수, 유액, 메이크업 베이스, 에센스, 비누, 액체 세정료, 입욕제, 선 스크린 크림, 선 오일, 현탁액, 유탁액, 페이스트, 겔, 로션, 파우더, 비누, 계면 활성제-함유 클렌징, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션, 패취, 젤 타입 워시오프팩 및 스프레이로 구성된 군으로부터 선택되는 제형으로 제조할 수 있으나, 이에 제한되는 것은 아니다.The cosmetic composition of the present invention is a solution, external ointment, cream, foam, nourishing lotion, soft lotion, pack, soft water, emulsion, makeup base, essence, soap, liquid detergent, bath agent, sunscreen cream, sun oil, suspension, emulsion It can be prepared in a formulation selected from the group consisting of liquid, paste, gel, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, patch, gel-type wash-off pack, and spray. However, the present invention is not limited thereto.
본 발명의 상기 화장료 조성물은 일반 피부 화장료에 배합되는 화장품학적으로 허용 가능한 담체를 1종 이상 추가로 포함할 수 있으며, 통상의 성분으로 예를 들면 유분, 물, 계면 활성제, 보습제, 저급 알코올, 증점제, 킬레이트제, 색소, 방부제, 향료 등을 적절히 배합할 수 있으나, 이에 제한되는 것은 아니다.The cosmetic composition of the present invention may further include one or more cosmetically acceptable carriers to be formulated in general skin cosmetics, and common ingredients include, for example, oil, water, surfactant, humectant, lower alcohol, and thickener. , a chelating agent, a colorant, a preservative, a fragrance, and the like may be appropriately blended, but the present invention is not limited thereto.
본 발명의 화장료 조성물에 포함되는 화장품학적으로 허용 가능한 담체는 화장료 조성물의 제형에 따라 다양하게 적용될 수 있다.The cosmetically acceptable carrier included in the cosmetic composition of the present invention may be applied in various ways depending on the formulation of the cosmetic composition.
본 발명의 제형이 연고, 페이스트, 크림 또는 젤인 경우에는, 담체 성분으로서 동물성 유, 식물성 유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크, 산화 아연 등이 이용될 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2 종 이상 혼합되어 사용될 수 있다.When the formulation of the present invention is an ointment, paste, cream or gel, as a carrier component, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide, etc. may be used, but is not limited thereto. These may be used alone or in combination of two or more.
본 발명의 제형이 파우더 또는 스프레이인 경우에는, 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록사이드, 칼슘 실케이트, 폴리아미드 파우더 등이 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로하드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진제를 포함할 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2 종 이상 혼합되어 사용될 수 있다.When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, etc. may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohard propellants such as, but not limited to, locarbon, propane/butane or dimethyl ether. These may be used alone or in combination of two or more.
본 발명의 제형이 용액 또는 유탁액인 경우에는, 담체 성분으로서 용매, 용해화제 또는 유탁화제 등이 이용될 수 있으며, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일 등이 이용될 수 있고, 특히, 목화씨 오일, 땅콩 오일, 옥수수 배종 오일, 올리브 오일, 피마자 오일 및 참깨 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 이용될 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2 종 이상 혼합되어 사용될 수 있다.When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer, or emulsifier may be used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, Propylene glycol, 1,3-butylglycol oil and the like can be used, and in particular, cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol aliphatic esters, fatty acid esters of polyethylene glycol or sorbitan may be used, but is not limited thereto. These may be used alone or in combination of two or more.
본 발명의 제형이 현탁액인 경우에는, 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타하이드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2 종 이상 혼합되어 사용될 수 있다.When the formulation of the present invention is a suspension, as a carrier component a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters; Crystalline cellulose, aluminum metahydroxide, bentonite, agar or tracanth may be used, but is not limited thereto. These may be used alone or in combination of two or more.
본 발명의 제형이 비누인 경우에는, 담체 성분으로서 지방산의 알칼리 금속 염, 지방산 헤미에스테르 염, 지방산 단백질 히드롤리제이트, 이세티오네이트, 라놀린 유도체, 지방족 알코올, 식물성 유, 글리세롤, 당 등이 이용될 수 있으나, 이에 제한되는 것은 아니다. 이들은 단독으로 사용되거나 2종 이상 혼합되어 사용될 수 있다.
When the formulation of the present invention is a soap, alkali metal salts of fatty acids, fatty acid hemiester salts, fatty acid protein hydrolysates, isethionate, lanolin derivatives, aliphatic alcohols, vegetable oils, glycerol, sugar, etc. are used as carrier components. may be, but is not limited thereto. These may be used alone or in combination of two or more.
또 다른 본 발명의 일 구현예는 카모마일 꽃 분말을 포함하는, 피부 혈행 개선용 의약외품 조성물을 제공한다. 카모마일, 카모마일 꽃 분말, 혈행 개선에 대해서는 앞서 설명한 바와 같다.Another embodiment of the present invention provides a quasi-drug composition for improving skin blood circulation, comprising chamomile flower powder. Chamomile, chamomile flower powder, and blood circulation improvement are the same as described above.
본 발명에서, 상기 의약외품 조성물은 카모마일 추출물, 이의 분획물 또는 글리세린 중 하나 이상을 추가로 포함할 수 있으며, 카모마일 추출물, 이의 분획물 및 글리세린은 앞서 설명한 바와 같다.In the present invention, the quasi-drug composition may further include one or more of a chamomile extract, a fraction thereof, and glycerin, and the chamomile extract, a fraction thereof, and glycerin are as described above.
본 발명의 의약외품 조성물에는 상기 성분 외에 필요에 따라 약학적으로 허용가능한 담체, 부형제 또는 희석제를 더욱 포함할 수 있다. 상기 약학적으로 허용가능한 담체, 부형제 또는 희석제는 본 발명의 효과를 해하지 않는한 특히 제한되지 않으며, 예를 들어 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제, 윤활제, 감미제, 방향제, 보존제 등을 포함할 수 있다.The quasi-drug composition of the present invention may further include a pharmaceutically acceptable carrier, excipient or diluent if necessary in addition to the above components. The pharmaceutically acceptable carrier, excipient or diluent is not particularly limited as long as it does not impair the effects of the present invention, for example, a filler, an extender, a binder, a wetting agent, a disintegrant, a surfactant, a lubricant, a sweetener, a fragrance, a preservative, etc. may include.
약학적으로 허용가능한 담체, 부형제 또는 희석제의 대표적인 예로는, 락토즈, 덱스트로스, 슈크로스, 솔비톨, 만니톨, 자일리톨, 말티톨, 전분, 젤라틴, 글리세린, 아카시아 고무, 알지네이트, 칼슘포스페이트, 칼슘카보네이트, 칼슘실리케이트, 셀룰로즈, 메틸 셀룰로즈, 미정질 셀룰로즈, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 탈크, 마그네슘 스테아레이트, 광물유, 프로필렌글리콜, 폴리에틸렌글리콜, 식물성 오일, 주사가능한 에스테르, 위텝솔, 마크로골, 트윈 61, 카카오지, 라우리지 등을 들 수 있다.Representative examples of pharmaceutically acceptable carriers, excipients or diluents include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, maltitol, starch, gelatin, glycerin, gum acacia, alginate, calcium phosphate, calcium carbonate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, mineral oil, propylene glycol, polyethylene glycol, vegetable oil, injectable Ester, Witepsol, Macrogol, Tween 61, cacao butter, laurage, etc. are mentioned.
의약외품 조성물은 소독 청결제, 샤워폼, 연고액, 물티슈, 코팅제 등을 예시할 수 있으나 이에 제한되는 것이 아니며, 의약외품의 제제화 방법, 용량, 이용방법, 구성성분 등은 기술분야에 공지된 통상의 기술로부터 적절히 선택될 수 있다.
The quasi-drug composition may include, but is not limited to, disinfection cleaner, shower foam, ointment, wet tissue, coating agent, etc. may be appropriately selected.
또 다른 본 발명의 일 구현예는 카모마일 꽃 분말을 포함하는, 피부 혈행 개선용 식품 조성물을 제공한다. 카모마일, 카모마일 꽃 분말, 혈행 개선에 대해서는 앞서 설명한 바와 같다.Another embodiment of the present invention provides a food composition for improving skin blood circulation, comprising chamomile flower powder. Chamomile, chamomile flower powder, and blood circulation improvement are the same as described above.
본 발명에서, 상기 식품 조성물은 카모마일 추출물, 이의 분획물 또는 글리세린 중 하나 이상을 추가로 포함할 수 있으며, 카모마일 추출물, 이의 분획물 및 글리세린은 앞서 설명한 바와 같다.In the present invention, the food composition may further include one or more of a chamomile extract, a fraction thereof, and glycerin, and the chamomile extract, a fraction thereof, and glycerin are as described above.
본 발명의 식품 조성물은 환제, 분말, 과립, 침제, 정제, 캡슐 또는 액제 등의 형태를 포함하며, 본 발명의 카모마일 꽃 분말을 포함할 수 있는 식품의 종류에는 별다른 제한이 없으며, 예를 들어 각종 음료, 껌, 차, 비타민 복합제, 건강보조 식품류 등이 있다.The food composition of the present invention includes the form of pills, powders, granules, needles, tablets, capsules or liquids, and there is no particular limitation on the type of food that can contain the chamomile flower powder of the present invention, for example, various There are beverages, gum, tea, vitamin complexes, and health supplements.
또한, 상기 식품 조성물에는 카모마일 꽃 분말 외에도 혈행 개선 효과에 방해가 되지 않는 다른 성분을 추가할 수 있으며, 그 종류는 특별히 제한되지 않는다. 예를 들어, 통상의 식품과 같이 여러 가지 생약 추출물, 식품학적으로 허용가능한 식품보조첨가제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다.In addition, other ingredients that do not interfere with the blood circulation improvement effect in addition to the chamomile flower powder may be added to the food composition, and the type thereof is not particularly limited. For example, it may contain various herbal extracts, food-logically acceptable food supplements or natural carbohydrates as additional ingredients, such as conventional foods.
본 발명에서 사용된 용어 "식품보조첨가제"란, 식품에 보조적으로 첨가될 수 있는 구성요소를 의미하며, 각 제형의 건강기능식품을 제조하는데 첨가되는 것으로서 당업자가 적절히 선택하여 사용할 수 있다. 식품보조첨가제의 예로는 여러 가지 영양제, 비타민, 광물 (전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 충진제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산음료에 사용되는 탄산화제 등이 포함되지만, 상기 예들에 의해 본 발명의 식품보조첨가제의 종류가 제한되는 것은 아니다.As used in the present invention, the term "food supplement additive" refers to a component that can be supplementally added to food, and is added to prepare a health functional food of each formulation, and those skilled in the art can appropriately select and use it. Examples of food supplement additives include various nutrients, vitamins, minerals (electrolytes), synthetic flavoring agents and flavoring agents such as natural flavoring agents, coloring agents and fillers, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners , pH adjusters, stabilizers, preservatives, glycerin, alcohol, carbonation agents used in carbonated beverages, etc., but the above examples are not limited to the types of food supplement additives of the present invention.
상기 천연 탄수화물의 예는 포도당, 과당 등의 단당류; 말토스, 수크로스 등의 이당류; 및 덱스트린, 시클로덱스트린 등의 다당류와, 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 상술한 것 이외의 향미제로서 천연 향미제 (타우마틴, 스테비아 추출물 (예를 들어 레바우디오시드 Ａ, 글리시르히진 등) 및 합성 향미제 (사카린, 아스파르탐 등)를 유리하게 사용할 수 있다.Examples of the natural carbohydrate include monosaccharides such as glucose and fructose; disaccharides such as maltose and sucrose; and polysaccharides such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents other than those described above, natural flavoring agents (taumatin, stevia extract (eg, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. .
본 발명의 식품 조성물에는 건강기능성 식품이 포함될 수 있다. 본 발명에서 사용된 용어 "건강기능성 식품"이란 인체에 유용한 기능성을 가진 원료나 성분을 사용하여 정제, 캅셀, 분말, 과립, 액상 및 환 등의 형태로 제조 및 가공한 식품을 말한다. 여기서 기능성이라 함은 인체의 구조 및 기능에 대하여 영양소를 조절하거나 생리학적 작용 등과 같은 보건 용도에 유용한 효과를 얻는 것을 의미한다. 본 발명의 건강기능성 식품은 당업계에서 통상적으로 사용되는 방법에 의하여 제조가능하며, 상기 제조시에는 당업계에서 통상적으로 첨가하는 원료 및 성분을 첨가하여 제조할 수 있다. 또한, 일반 약품과는 달리 식품을 원료로 하여 약품의 장기 복용 시 발생할 수 있는 부작용 등이 없는 장점이 있고, 휴대성이 뛰어날 수 있다.The food composition of the present invention may include a health functional food. As used herein, the term "health functional food" refers to food manufactured and processed in the form of tablets, capsules, powders, granules, liquids, pills, etc. using raw materials or ingredients useful in the human body. Here, the term "functionality" refers to obtaining useful effects for health purposes, such as regulating nutrients or physiological effects with respect to the structure and function of the human body. The health functional food of the present invention can be prepared by a method commonly used in the art, and at the time of manufacture, it can be prepared by adding raw materials and components commonly added in the art. In addition, unlike general drugs, there is an advantage in that there are no side effects that may occur when taking the drug for a long time by using food as a raw material, and it can be excellent in portability.
상기 식품의 종류에는 특별한 제한은 없다. 상기 물질을 첨가할 수 있는 식품의 예로는 육류, 소시지, 빵, 초콜릿, 캔디류, 스넥류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 수프, 음료수, 차, 드링크제, 알코올 음료 및 비타민 복합제 등이 있으며, 통상적인 의미에서의 건강기능성 식품을 모두 포함할 수 있다.
There is no particular limitation on the type of the food. Examples of foods to which the above substances can be added include meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, dairy products including ice cream, various soups, beverages, tea, drinks, There are alcoholic beverages, vitamin complexes, and the like, and may include all health functional foods in a conventional sense.
본 발명의 피부 혈행 개선용 조성물은 피부 모세혈관의 확장을 통해 혈액 순환을 원활하게 하여 우수한 혈류량 개선 효과를 나타내면서도 피부에 자극이 없고 독성이 없는바 화장료 조성물, 의약외품 조성물 또는 식품 조성물로 활용될 수 있다.
The composition for improving skin blood circulation of the present invention facilitates blood circulation through the expansion of skin capillaries, thereby exhibiting an excellent blood flow improvement effect, and is non-irritating and non-toxic to the skin. It can be used as a cosmetic composition, quasi-drug composition or food composition. have.
도 1은 실시예 1 내지 4 및 비교예 1 내지 4의 조성물을 피부에 도포한 후 피부 혈류량을 측정하여 혈류량 증가율을 그래프로 나타낸 것이다.
도 2는 실시예 1 내지 4 및 비교예 1 내지 4의 조성물을 피부에 도포한 후 피부 생기 개선 효과에 대한 설문조사 결과를 그래프로 나타낸 것이다.
도 3은 카모마일 꽃 분말, 카모마일 추출물 및 글리세린을 포함한 화장료 조성물을 나타낸 것이다.1 is a graph showing the blood flow increase rate by measuring the skin blood flow after applying the compositions of Examples 1 to 4 and Comparative Examples 1 to 4 to the skin.
2 is a graph showing the results of a survey on the skin vitality improvement effect after the compositions of Examples 1 to 4 and Comparative Examples 1 to 4 were applied to the skin.
3 shows a cosmetic composition including chamomile flower powder, chamomile extract, and glycerin.
이하, 실시예를 통하여 본 발명의 구성 및 효과를 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 예시하기 위한 것일 뿐 본 발명의 범위가 이들 실시예에 의해 제한되는 것은 아니다.
Hereinafter, the configuration and effects of the present invention will be described in more detail through examples. These examples are only for illustrating the present invention, and the scope of the present invention is not limited by these examples.
실시예 1 내지 4 및 비교예 1 내지 4 조성물의 제조Examples 1 to 4 and Comparative Examples 1 to 4 Preparation of compositions
하기 표 1에 나타난 바와 같이, 실시예 1은 카모마일 꽃 분말(표 1 내 카모마일꽃(가루)로 표시)만을 배합하여 제조하였으며, 실시예 2는 카모마일 꽃 분말 및 글리세린을 배합하여 제조하였고, 실시예 3은 카모마일 꽃 분말 및 카모마일 추출물을 배합하여 제조하였다. 또한, 실시예 4는 카모마일 꽃 분말, 카모마일 추출물 및 글리세린을 모두 배합하여 제조하였다.As shown in Table 1 below, Example 1 was prepared by combining only chamomile flower powder (represented as chamomile flower (powder) in Table 1), Example 2 was prepared by combining chamomile flower powder and glycerin, Example 3 was prepared by combining chamomile flower powder and chamomile extract. In addition, Example 4 was prepared by combining all of chamomile flower powder, chamomile extract, and glycerin.
비교예 1은 카모마일 꽃 분말, 카모마일 추출물 및 글리세린이 모두 포함되지 않도록 하여 제조하였고, 비교예 2는 글리세린만을 배합하였으며, 비교예 3은 카모마일 추출물만을 배합하여 제조하였다. 또한, 비교예 4는 카모마일 추출물 및 글리세린을 배합하여 제조하였다.
Comparative Example 1 was prepared so as not to contain all of chamomile flower powder, chamomile extract, and glycerin, Comparative Example 2 was prepared by mixing only glycerin, and Comparative Example 3 was prepared by mixing only chamomile extract. In addition, Comparative Example 4 was prepared by combining the chamomile extract and glycerin.
상기 카모마일 꽃 분말은 이집트산 유기농 저먼(German) 카모마일 100g을 정제수 1ℓ에 첨가하여 60℃ 이상에서 3시간 가열 후 100 Mesh portable Filter를 사용하여 자연 낙하로 카모마일 꽃잎만을 걸러내고, 2~3회 정제수로 헹궈준 다음 남겨진 카모마일 꽃잎을 2~5일간 열풍건조하여 얻은 카모마일 꽃 분말 (㈜내츄럴솔루션)을 사용하였다.
The chamomile flower powder is obtained by adding 100 g of Egyptian organic German chamomile to 1 liter of purified water, heating it at 60° C. or higher for 3 hours, and then using a 100 Mesh portable filter to filter out only the chamomile petals by natural fall, and use purified water 2-3 times. Chamomile flower powder (Natural Solution, Inc.) obtained by drying the chamomile petals left after rinsing with hot air for 2 to 5 days was used.
상기 카모마일 추출물은 이집트산 유기농 저먼(German) 카모마일을 추출하여 얻은 Chamomile TinctureTM(LP)(㈜내츄럴솔루션)를 이용하였으며, 글리세린은 ELOGLYN R980 글리세린 벌크(㈜엘지생활건강)를 사용하였다.
As the chamomile extract, Chamomile Tincture TM (LP) (Natural Solution) obtained by extracting Egyptian organic German chamomile was used, and as glycerin, ELOGLYN R980 glycerin bulk (LG Household & Health Care) was used.
구체적으로, 상기 실시예 1 내지 4 및 비교예 1 내지 4의 조성에 따라 수상과 가용화상을 45℃에서 교반하여 완전히 용해시킨 다음, 수상에 가용화상을 서서히 투입하면서 4,000 내지 5,000rpm으로 2 내지 7분간 교반 후, 후첨 1을 투입하고 4,000 내지 5,000rpm으로 2 내지 7분간 교반한 후 30℃까지 냉각, 탈포한 후 후첨 2를 투입하고 4,000 내지 5,000rpm으로 1 내지 2분간 교반하여 제조하였다.
Specifically, according to the compositions of Examples 1 to 4 and Comparative Examples 1 to 4, the aqueous phase and the solubilized image are completely dissolved by stirring at 45° C., and then the solubilized image is slowly added to the aqueous phase while gradually introducing 2 to 7 at 4,000 to 5,000 rpm. After stirring for minutes, the latter was added and stirred at 4,000 to 5,000 rpm for 2 to 7 minutes, cooled to 30° C. and defoamed, and then added with the latter 2 and stirred at 4,000 to 5,000 rpm for 1 to 2 minutes.
상기 실시예 1 내지 4 및 비교예 1 내지 4에 따라 제조된 조성물의 피부 자극성을 알아보기 위한 실험을 수행하였다. 건강한 성인남녀 25명을 대상으로 등부위에 각 시료의 일정량(0.2g)을 24시간 첩포한 후, 핀챔버를 제거하고 4시간 경과한 다음 육안으로 피부상태 변화를 판독하여 그 결과를 하기 표 2에 나타내었다. 자극도를 평가하기 위한 수식은 하기 수학식 1에 나타내었다.
An experiment was performed to determine the skin irritation of the compositions prepared according to Examples 1 to 4 and Comparative Examples 1 to 4. After applying a certain amount (0.2 g) of each sample to the back of 25 healthy adult men and women for 24 hours, remove the pin chamber, and after 4 hours have elapsed, the skin condition was visually read and the results are shown in Table 2 below. indicated. Equation for evaluating the degree of stimulation is shown in Equation 1 below.
* 판정 기준 * Criteria
- ; 홍반이나 특이한 현상 없음.- ; No erythema or unusual symptoms.
+- ; 주위보다 약간 붉어짐+- ; Slightly redder than around
+ ; 주위보다 현저히 붉어짐+ ; Significantly redder than surrounding
++ ; 주위보다 심하게 붉어지고 부풀어 오름
++ ; Redness and swelling more severe than the surrounding area
표 2에 나타난 바와 같이, 카모마일 꽃 분말만을 유효성분으로 포함하고 있는 실시예 1 및 카모마일 꽃 분말, 카모마일 추출물 및 글리세린을 모두 포함하는 실시예 4의 피부 자극도는 상기 유효성분을 전혀 포함하지 않은 비교예 1에 비해 낮게 나타났다. 또한, 실시예 2 및 실시예 3의 경우에도 피부에 대한 자극도는 비교예 1과 유사한 수준으로 나타났다.
As shown in Table 2, the skin irritation degree of Example 1 containing only chamomile flower powder as an active ingredient and Example 4 containing both chamomile flower powder, chamomile extract, and glycerin was a comparison in which the active ingredient was not included at all. It was lower than that of Example 1. In addition, in the case of Examples 2 and 3, the degree of irritation to the skin was found to be at a level similar to that of Comparative Example 1.
상기와 같은 결과로부터, 카모마일 꽃 분말을 포함하는 실시예 1 내지 4의 피부에 대한 자극도가 낮아, 피부에 무해함을 알 수 있었다.
From the above results, it was found that the degree of irritation to the skin of Examples 1 to 4 containing the chamomile flower powder was low and harmless to the skin.
실험예 2. 피부 혈행 개선효과 분석Experimental Example 2. Analysis of skin blood circulation improvement effect
상기 실시예 1 내지 4 및 비교예 1 내지 4에 따라 제조된 조성물의 피부 혈행 개선효과를 알아보기 위한 테스트를 수행하였다.A test was performed to determine the skin blood circulation improvement effect of the compositions prepared according to Examples 1 to 4 and Comparative Examples 1 to 4.
20~40대 여성 25명에게 시험 제품을 10분 동안 얼굴 전체에 도포하도록 하였다. 사용 전과 사용 10분 후, 각 평가 시점에서 Laser Doppler Perfusion Imager (LDPI, PeriScan PIM Ⅱ, Perimed AB,Sweden)를 이용하여 볼 부위의 혈류량을 측정하고 그 결과를 분석하였다. 상기 Laser Doppler Perfusion Imager는 도플러 이론에 기초하여 미세 조직 혈류량 (blood perfusion)을 측정하는 것으로, 측정단위는 임의의 단위 (AU, arbitrary unit)이다.Twenty-five women in their 20s and 40s were asked to apply the test product to the entire face for 10 minutes. Before and 10 minutes after use, at each evaluation time point, the blood flow in the cheek area was measured using a Laser Doppler Perfusion Imager (LDPI, PeriScan PIM Ⅱ, Perimed AB, Sweden) and the results were analyzed. The Laser Doppler Perfusion Imager measures microscopic tissue blood perfusion based on Doppler theory, and the measurement unit is an arbitrary unit (AU, arbitrary unit).
측정부위인 볼 부위에 대해 Laser Doppler Perfusion Imager 및 image analysis software(LDPIwin version 2.6)를 이용하여 혈류량을 측정하고, 결과를 분석하였다. 실내외 조명 및 빛을 모두 차단한 공간 내에서 측정조건(해상도, 측정거리 등)을 동일하게 하여 측정하였다. For the cheek area, which is the measurement site, blood flow was measured using Laser Doppler Perfusion Imager and image analysis software (LDPIwin version 2.6), and the results were analyzed. Measurements were made with the same measurement conditions (resolution, measurement distance, etc.) in a space where both indoor and outdoor lighting and light were blocked.
LDPI에 의한 혈류량 증가율은 하기의 수학식 2를 이용하여 계산하였으며, 이의 결과는 하기 표 3에 나타내었다.
The blood flow increase rate by LDPI was calculated using Equation 2 below, and the results are shown in Table 3 below.
표 3에 나타난 바와 같이, 피부 혈류량 분석 결과, 카모마일 꽃 분말을 포함하고 있는 실시예 1 내지 4 모두 사용 전에 비해 혈류량이 유의하게 개선되었으며, 이는 비교예 1 내지 4에 비해 높은 개선율을 나타내는 것임을 확인할 수 있었다. 구체적으로, 카모마일 꽃 분말, 카모마일 추출물 및 글리세린을 모두 포함하는 실시예 4의 경우 사용 전에 비해 79.35% 개선된 것을 알 수 있었으며, 카모마일 꽃 분말만을 포함한 실시예 1의 경우에도 사용 전에 비해 48.39%의 개선 효과를 나타내는 것을 알 수 있었다. 특히 카모마일 추출물만을 포함한 비교예 3의 경우 개선율은 18.09%, 카모마일 추출물 및 글리세린을 포함한 비교예 4의 경우 개선율은 22.58%에 불과하여, 카모마일 꽃 분말을 포함한 경우의 피부 혈행 개선효과가 우수함을 확인할 수 있었다(표 3 및 도 1).
As shown in Table 3, as a result of skin blood flow analysis, it can be confirmed that Examples 1 to 4 containing chamomile flower powder significantly improved blood flow compared to before use, which shows a higher improvement rate compared to Comparative Examples 1 to 4. there was. Specifically, in the case of Example 4 containing both chamomile flower powder, chamomile extract, and glycerin, it was found that 79.35% improved compared to before use, and in the case of Example 1 containing only chamomile flower powder, 48.39% improvement compared to before use was found to be effective. In particular, in Comparative Example 3 containing only the chamomile extract, the improvement rate was 18.09%, and in Comparative Example 4 containing the chamomile extract and glycerin, the improvement rate was only 22.58%, confirming that the skin blood circulation improvement effect was excellent when the chamomile flower powder was included. (Table 3 and Figure 1).
실험예 3. 피부 생기 효과 분석Experimental Example 3. Analysis of skin vitality effect
실시예 1 내지 4 및 비교예 1 내지 4에 따라 제조된 조성물의 피부 혈행 개선을 통한 피부 생기(맑고 투명함) 효과를 평가하였으며, 상기 실험예 2에서 화장료 조성물에 대한 테스트를 수행한 후 이어서 설문 조사와 육안적 소견을 종합하여 피부 생기 효과를 분석하였다.The skin vitality (clear and transparent) effect of the compositions prepared according to Examples 1 to 4 and Comparative Examples 1 to 4 was evaluated through improvement of skin blood circulation, and after performing a test on the cosmetic composition in Experimental Example 2, a questionnaire The skin vitality effect was analyzed by synthesizing the survey and the gross findings.
효과 체감율은 하기의 수학식 3을 이용하여 계산하였으며, 이의 결과는 하기 표 4에 나타내었다.
The effect diminishing rate was calculated using Equation 3 below, and the results are shown in Table 4 below.
피부 혈행 개선에 의한 생기 효과를 인정할 수 있는 ‘효과 있음’ 및 ‘약간 효과 있음’의 비율을 살펴보면, 유효성분으로 카모마일 꽃 분말만을 포함하는 실시예 1의 경우 76%의 생기 개선 효과가 나타남을 알 수 있었다. 또한, 카모마일 꽃 분말 및 글리세린을 포함하는 실시예 2 및 카모마일 꽃 분말 및 카모마일 추출물을 포함하는 실시예 3의 경우에도 각각 76%, 88%의 생기 개선 효과를 나타냄을 확인하였다.Looking at the ratio of 'have an effect' and 'have a slight effect', which can recognize the vitality effect by improving skin blood circulation, it can be seen that in Example 1 containing only chamomile flower powder as an active ingredient, a vitality improvement effect of 76% appears. could In addition, it was confirmed that Example 2 containing chamomile flower powder and glycerin and Example 3 containing chamomile flower powder and chamomile extract showed vitality improvement effects of 76% and 88%, respectively.
또한, 카모마일 꽃 분말을 포함하지 않은 비교예 1 내지 4의 경우 개선 효과가 4% 내지 20%에 불과하였으며, 카모마일 추출물만 포함한 비교예 3 및 카모마일 추출물 및 글리세린을 포함한 비교예 4의 경우 개선 효과가 각각 20%로 나타나, 카모마일 꽃 분말을 포함하였을 때의 개선 효과가 더욱 우수함을 알 수 있었다.In addition, in Comparative Examples 1 to 4, which did not contain chamomile flower powder, the improvement effect was only 4% to 20%, and in Comparative Example 3 including only the chamomile extract and Comparative Example 4 including the chamomile extract and glycerin, the improvement effect was Each was 20%, indicating that the improvement effect was more excellent when the chamomile flower powder was included.
특히, 카모마일 꽃 분말, 카모마일 추출물 및 글리세린을 모두 포함하는 실시예 4의 조성물의 경우 96%에 달하는 개선 효과를 나타내어, 피부 혈행 개선에 의한 생기 효과가 매우 우수함을 확인할 수 있었다(표 4 및 도 2).
In particular, the composition of Example 4 containing both chamomile flower powder, chamomile extract and glycerin showed an improvement effect of 96%, confirming that the vitality effect by improving skin blood circulation was very excellent (Table 4 and FIG. 2) ).
제조예 1. 본 발명 실시예 1 내지 4 중 어느 하나의 조성물을 포함하는 젤 타입 워시오프팩 제조Preparation Example 1. Preparation of a gel-type wash-off pack comprising the composition of any one of Examples 1 to 4 of the present invention
하기의 표 5와 같이 에센스 제형의 화장료 조성물을 제조하였다(단위: 중량%).
As shown in Table 5 below, a cosmetic composition of an essence formulation was prepared (unit: wt%).
제조예 2. 카모마일 꽃 분말을 포함하는 에센스 제조Preparation Example 2. Preparation of Essence Containing Chamomile Flower Powder
하기의 표 6과 같이 에센스 제형의 화장료 조성물을 제조하였다(단위: 중량%).
As shown in Table 6 below, a cosmetic composition of an essence formulation was prepared (unit: wt%).
제조예 3. 카모마일 꽃 분말을 포함하는 크림 제조Preparation Example 3. Preparation of cream containing chamomile flower powder
하기의 표 7과 같이 크림 제형의 화장료 조성물을 제조하였다(단위: 중량%).
A cosmetic composition of a cream formulation was prepared as shown in Table 7 below (unit: wt%).
제조예 4. 카모마일 꽃 분말을 포함하는 건강기능식품 제조Preparation Example 4. Preparation of health functional food containing chamomile flower powder
카모마일 꽃 분말 2%, 유당 54.0%, 스테아린산마그네슘 0.49% 및 레시틴 0.01%를 배합기에서 골고루 혼합한 다음 성형기로 성형하여 카모마일 꽃 분말이 포함된 건강식품을 제조하였다.
2% of chamomile flower powder, 54.0% of lactose, 0.49% of magnesium stearate and 0.01% of lecithin were mixed evenly in a mixing machine and then molded with a molding machine to prepare a health food containing chamomile flower powder.
제조예 5. 카모마일 꽃 분말을 포함하는 음료 제조Preparation 5. Preparation of beverage containing chamomile flower powder
유화제로서 레시틴 0.3중량%를 80℃로 가열한 정제수에 1,120rpm으로 교반하면서 충분히 용해시킨 후에 카모마일 꽃 분말 2.0중량%를 1,120rpm으로 교반하면서 가하여 60℃에서 용해시키고, 액상과당 6.0중량%를 비롯하여 구연산 0.5중량%, 벌꿀 3.0중량%, 안식향산나트륨 0.05중량% 등 나머지 원료를 정제수에 완전히 용해시켰다. 총 함량 100중량%가 되도록 정제수를 잔량 가하여 카모마일 꽃 분말을 포함하는 음료를 제조하였다.
After dissolving 0.3% by weight of lecithin as an emulsifier in purified water heated to 80°C while stirring at 1,120rpm, 2.0% by weight of chamomile flower powder was added while stirring at 1,120rpm and dissolved at 60°C, and citric acid including 6.0% by weight of liquid fructose 0.5% by weight, honey 3.0% by weight, sodium benzoate 0.05% by weight, etc. The remaining raw materials were completely dissolved in purified water. A beverage containing chamomile flower powder was prepared by adding the remaining amount of purified water so that the total content was 100% by weight.
이상의 설명으로부터, 본 발명이 속하는 기술분야의 통상의 기술자는 본 발명이 그 기술적 사상이나 필수적 특징을 변경하지 않고서 다른 구체적인 형태로 실시될 수 있다는 것을 이해할 수 있을 것이다. 이와 관련하여, 이상에서 기술한 실시 예들은 모든 면에서 예시적인 것이며 한정적인 것이 아닌 것으로서 이해해야만 한다. 본 발명의 범위는 상기 상세한 설명보다는 후술하는 특허 청구범위의 의미 및 범위 그리고 그 등가 개념으로부터 도출되는 모든 변경 또는 변형된 형태가 본 발명의 범위에 포함되는 것으로 해석되어야 한다.From the above description, those skilled in the art to which the present invention pertains will be able to understand that the present invention may be embodied in other specific forms without changing the technical spirit or essential characteristics thereof. In this regard, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. The scope of the present invention should be construed as being included in the scope of the present invention, rather than the above detailed description, all changes or modifications derived from the meaning and scope of the claims described below and their equivalents.
Claims (8)
A cosmetic composition for improving skin blood circulation, comprising chamomile flower powder and chamomile extract.
The cosmetic composition for improving skin blood circulation according to claim 1, comprising 0.0001 to 2% by weight of the chamomile flower powder with respect to 100% by weight of the total composition.
The cosmetic composition for improving skin blood circulation according to claim 1, wherein the chamomile flower powder is obtained by pulverizing chamomile flowers after hot air drying.
The cosmetic composition for improving skin blood circulation according to claim 1, further comprising glycerin.
The cosmetic composition of claim 1, wherein the chamomile extract is a chamomile tincture extract.
The cosmetic composition for improving skin blood circulation according to any one of claims 1 to 5, wherein the chamomile is German chamomile.
A quasi-drug composition for improving skin blood circulation, comprising chamomile flower powder and chamomile extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020140129136A KR102309956B1 (en) | 2014-09-26 | 2014-09-26 | Composition for improving the skin blood flow containing chamomile flower powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020140129136A KR102309956B1 (en) | 2014-09-26 | 2014-09-26 | Composition for improving the skin blood flow containing chamomile flower powder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160037304A KR20160037304A (en) | 2016-04-06 |
| KR102309956B1 true KR102309956B1 (en) | 2021-10-08 |
Family
ID=55790305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020140129136A KR102309956B1 (en) | 2014-09-26 | 2014-09-26 | Composition for improving the skin blood flow containing chamomile flower powder |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR102309956B1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102324984B1 (en) | 2021-06-08 | 2021-11-12 | (주)나우코스 | Natural essential oil composition for skin application to improve skin blood flow and Cosmetic composition comprising the same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002193783A (en) * | 2000-12-27 | 2002-07-10 | Kanebo Ltd | Cosmetic composition |
| JP2005068069A (en) * | 2003-08-25 | 2005-03-17 | Japan Science & Technology Agency | Chamomile extraction essence having bloodstream-ameliorating activity and heart rate-educing activity, and method for producing the same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100858629B1 (en) | 2007-02-28 | 2008-09-17 | 주식회사 코리아나화장품 | Cosmetic Composition for increasing the Skin Energy Comprising Chamaecyparis obtusa, Pinus thunbergii and Pinus bungeana Extract |
| KR100977673B1 (en) | 2008-04-08 | 2010-08-24 | 주식회사 코리아나화장품 | Cosmetic Composition For Stimulating the Blood Circulation and For Improving the Skin Color Containing Plant Complex Extracts |
-
2014
- 2014-09-26 KR KR1020140129136A patent/KR102309956B1/en active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002193783A (en) * | 2000-12-27 | 2002-07-10 | Kanebo Ltd | Cosmetic composition |
| JP2005068069A (en) * | 2003-08-25 | 2005-03-17 | Japan Science & Technology Agency | Chamomile extraction essence having bloodstream-ameliorating activity and heart rate-educing activity, and method for producing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20160037304A (en) | 2016-04-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102348042B1 (en) | Composition for improving skin condition comprising extract of hydrangea serrata | |
| KR102113193B1 (en) | Composition for improving skin conditions comprising artemisiae annuae herba, centella asiatica and green tea extract or fraction thereof and method for improving skin conditions using the same | |
| KR100701606B1 (en) | The cosmetic composition with a herb medicine extract and the producing method thereof | |
| KR20140145278A (en) | Cosmetic composition containing Cimicifuga heracleifolia extract, Cornus officinalis extract and Geranium nepalense extract for skin convergence and elasticity effect | |
| KR20170025367A (en) | Composition for improving skin | |
| KR102472974B1 (en) | Composition for improving skin | |
| JP2020502172A (en) | Cosmetic composition containing Chinese herbal extract as active ingredient | |
| KR101914623B1 (en) | Composition for moisturizing skin comprising oil from plant as effective component | |
| US11389393B2 (en) | Composition for inhibiting sebum secretion comprising peach sprout extract | |
| KR102309956B1 (en) | Composition for improving the skin blood flow containing chamomile flower powder | |
| KR102425559B1 (en) | Composition for improving skin comprising an extract of Pueraria thomsonii or a compound derived therefrom | |
| KR101236348B1 (en) | Pack Composition | |
| KR20170025363A (en) | Composition for improving skin | |
| KR20160068303A (en) | Cosmetic composition for improving skin dryness, trouble or edema by hangover | |
| KR20140115228A (en) | Composition for prevention or treatment of hair loss comprising oriental herbal extracts | |
| KR20150010530A (en) | A cosmetic composition comprising critical extracts of pear | |
| KR102444462B1 (en) | Composition having antioxidant and skin whitening effect and its use | |
| KR20140074475A (en) | Cosmetic composition | |
| KR102644047B1 (en) | A composition for preventing or improving skin wrinkles or skin thermal aging comprising rosa multiflora extracts | |
| KR101506912B1 (en) | Cosmetic composition for pore minimizing and antioxidant containing extracts of quince, lemon balm or orange blossom | |
| KR100808418B1 (en) | Cosmetic composition comprising extracts of uncaria gambir roxburgh, cinnamomum zeylanicum nees, sanguisorba officinalis linne, nelumbo nucifera gaertner, pelargonium graveolens with astringent activity | |
| KR20170025365A (en) | Composition for improving skin | |
| KR102152932B1 (en) | Composition for improving skin conditions comprising catechin glycoside and method for improving skin conditions using the same | |
| KR20230101739A (en) | Cosmetic composition for skin improvement comprising Elaeocarpus sylvestris var. ellipticus extract | |
| JP6646408B2 (en) | Ceramide production promoter |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant |