CN105327238A - Traditional Chinese medicinal composition for tonifying spleen and stomach as well as preparation method and application of traditional Chinese medicinal composition - Google Patents

Abstract

The invention provides a traditional Chinese medicinal composition for tonifying spleen and stomach. The traditional Chinese medicinal composition mainly consists of the following medicinal raw materials: white hyacinth bean, Chinese yam, poria cocos, dark plum, concha ostreae, fructus citri sarcodactyli, fructus hordei germinatus, semen ziziphi spinosae, fructus ziziphi jujubae, arillus longan, fructus alpiniae oxyphyllae, mulberry, fructus crataegi, semen raphani and cordyceps militaris. Furthermore, the traditional Chinese medicinal composition consists of the following medicinal raw materials (in parts by weight): 3-15 parts of white hyacinth bean, 1-10 parts of Chinese yam, 3-15 parts of poria cocos, 1-8 parts of dark plum, 1-8 parts of concha ostreae, 1-8 parts of fructus citri sarcodactyli, 1-8 parts of fructus hordei germinatus, 3-15 parts of semen ziziphi spinosae, 1-8 parts of fructus ziziphi jujubae, 1-8 parts of arillus longan, 1-8 parts of fructus alpiniae oxyphyllae, 1-8 parts of mulberry, 1-8 parts of fructus crataegi, 1-10 parts of semen raphani and 3-15 parts of cordyceps militaris. Moreover, the invention provides a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition disclosed by the invention has functions of tonifying stomach and spleen, boosting organism immunity, calming nerves, promoting sleeping, inducing saliva and slaking thirst, tonifying brain and improving intelligence, and the like.

Description

Chinese medicine composition of a kind of strengthening the spleen and nourishing the stomach and its production and use

Technical field

The present invention relates to a kind of Chinese medicine composition and its production and use, be specifically related to Chinese medicine composition of a kind of strengthening the spleen and nourishing the stomach and preparation method thereof, belong to field of medicaments.

Background technology

Modern society is along with the development of economy, and people's work is day by day busy, has no time to attend to health, causes taste bad, insomnia and dreamful sleep, off feed, constipation, and immunity of organisms declines.

The treatment unbalance to transporting and transforming function of the spleen and stomach, generally adopts Chinese and western drugs, but Western medicine not only price is high, some medicines also have side effect.The Chinese prescription of strengthening the spleen and nourishing the stomach disclosed in prior art is also a lot, as Chinese patent application 201310153868.0 discloses by Radix Angelicae Sinensis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Schisandrae Chinensis, the strengthening the spleen and nourishing the stomach Chinese medicine composition of Radix Codonopsis composition, Chinese patent application 201210412316.2 discloses by the Radix Linderae, Rhizoma Polygoni Cuspidati, Fructus Aurantii Immaturus, the Chinese medicinal tablet of Semen Coicis composition, 201210136836.5 disclose by Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the pharmaceutical composition of the composition such as Pericarpium Citri Reticulatae, etc., but above-mentioned Chinese prescription makes pharmaceutical preparation as tablet more, capsule, pill, granule etc., side effect or erious adverse reaction, be unfavorable for long-term taking.

Health promoting wine, is commonly called as medicated wine, and the history of existing thousands of years is the important component part of Chinese Medicine science.In the successive dynasties medicine works of China, almost the record of disease body-building controlled by the medicated wine that has without exception.Nowadays, for this reason, the present invention is according to theory of Chinese medical science scientific compatibility, develop the health-care white spirit of taste good, both can meet the enjoyment of drinking, also benefit health: stomach invigorating, spleen invigorating, improve immunity of organisms, calm the nerves, sleeping, promoting the production of body fluid to quench thirst, the effects such as brain-nourishing intelligence-benefiting, to meet the able-bodied demand of people.

Summary of the invention

First object of the present invention is the Chinese medicine composition providing a kind of strengthening the spleen and nourishing the stomach.

Second object of the present invention is the preparation method providing said composition.

3rd object of the present invention is to provide said composition preparing the application had in the medicine of strengthening the spleen and nourishing the stomach effect.

The object of the invention is to be achieved through the following technical solutions:

A Chinese medicine composition for strengthening the spleen and nourishing the stomach, this Chinese medicine composition mainly comprises following crude drug: Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, Concha Ostreae, finger citron sliced, Fructus Hordei Germinatus, Semen Ziziphi Spinosae, Fructus Jujubae, Arillus Longan, Fructus Alpiniae Oxyphyllae, Fructus Mori, Fructus Crataegi, Semen Raphani, Cordyceps militaris (L.) Link..

Further, this traditional Chinese medicinal composition raw materials consists of (with listed as parts by weight):

Semen Lablab Album 3-15 part, Rhizoma Dioscoreae 1-10 part, Poria 3-15 part, Fructus Mume 1-8 part, Concha Ostreae 1-8 part, finger citron sliced 1-8 part, Fructus Hordei Germinatus 1-8 part, Semen Ziziphi Spinosae 3-15 part, Fructus Jujubae 1-8 part, Arillus Longan 1-8 part, Fructus Alpiniae Oxyphyllae 1-8 part, Fructus Mori 1-8 part, Fructus Crataegi 1-8 part, Semen Raphani 1-10 part, Cordyceps militaris (L.) Link. 3-15 part.

Further, its crude drug consists of:

Semen Lablab Album 3-12 part, Rhizoma Dioscoreae 1-7 part, Poria 3-12 part, Fructus Mume 1-6 part, Concha Ostreae 1-6 part, finger citron sliced 1-6 part, Fructus Hordei Germinatus 1-6 part, Semen Ziziphi Spinosae 3-12 part, Fructus Jujubae 1-6 part, Arillus Longan 1-6 part, Fructus Alpiniae Oxyphyllae 1-6 part, Fructus Mori 1-6 part, Fructus Crataegi 1-6 part, Semen Raphani 1-7 part, Cordyceps militaris (L.) Link. 3-12 part.

Further, its crude drug consists of:

Semen Lablab Album 3-8 part, Rhizoma Dioscoreae 1-5 part, Poria 3-8 part, Fructus Mume 1-4 part, Concha Ostreae 1-4 part, finger citron sliced 1-4 part, Fructus Hordei Germinatus 1-4 part, Semen Ziziphi Spinosae 3-8 part, Fructus Jujubae 1-4 part, Arillus Longan 1-4 part, Fructus Alpiniae Oxyphyllae 1-4 part, Fructus Mori 1-4 part, Fructus Crataegi 1-4 part, Semen Raphani 1-5 part, Cordyceps militaris (L.) Link. 3-8 part.

Further, its crude drug consists of:

Semen Lablab Album 4 parts, Rhizoma Dioscoreae 2 parts, 4 parts, Poria, Fructus Mume 1 part, Concha Ostreae 1 part, finger citron sliced 1 part, 1 part, Fructus Hordei Germinatus, Semen Ziziphi Spinosae 4 parts, 1 part, Fructus Jujubae, Arillus Longan 2 parts, Fructus Alpiniae Oxyphyllae 2 parts, Fructus Mori 2 parts, Fructus Crataegi 2 parts, Semen Raphani 2 parts, Cordyceps militaris (L.) Link. 6 parts.

Cordyceps militaris (L.) Link. of the present invention is Ascomycotina, Ergota Zoopagales, the type sepecies of Clavicipitaceae, Cordyceps, and formal name used at school is Cordycepsmilitaris, has another name called Cordyceps militaris (L.) Link., Cordyceps militaris etc.Worldwide distribution natural resources quantity is little.By Stroma (i.e. careless part) and sclerotium (i.e. the corpse part of worm) complex dimerous.Winter, larva lived in seclusion in soil, and mushroom parasitism wherein, draws nutrition, was full of mycelia and dead in larva body.To summer, on larva corpse, bear seedling, likeness in form grass, gathers before and after the Summer Solstice and obtains.

Chinese medicine composition of the present invention can extract preparation according to a conventional method, can also be further purified refining, can also add further customary adjuvant routinely preparation process be prepared into regular dosage form, include but not limited to health promoting beverage, oral liquid, granule, tablet, capsule, powder.

Described general extraction methods comprises one or more modes decocted in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects;

Described Extraction solvent is water or alcoholic solution; Be the ethanol of 30-80% further; Further be preferably the ethanol of 50-70%;

Described process for purification refine comprises water extract-alcohol precipitation, extraction or through macroporous resin column, silica column purification etc.

The preparation method of Chinese medicine composition of the present invention comprises:

Step 1: Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixing, with water extraction;

Step 2: the extracting solution that Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani and step 1 obtain after water extraction and medicinal residues mix, continuation water extraction; Extracting solution is concentrated obtains concentrated solution A;

Step 3: Cordyceps militaris (L.) Link. extracts with alcoholic solution, extracting solution is concentrated obtains concentrated solution B;

Step 4: merge concentrated solution A, B, obtain Chinese medicine composition.

Further, extracting method described in step 1,2 is decoct one or more modes in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects, and extraction time is 2-10 hour, and extraction time is 1-3 time; Further, extracting method described in step 1,2 is first soak extraction, then reflux, extract; Further, the described soak extraction time is 2-10 hour, and reflux, extract, number of times is 1-2 time, and each extraction time is 0.5-2 hour.

Further, alcoholic solution described in step 3 is the alcoholic solution of 30-80%; Further, described alcoholic solution is 50% alcoholic solution;

Further, extracting method described in step 3 is one or more modes in reflux, extract, soak extraction, supersound extraction or seepage pressure effects; Further, described extracting method is reflux, extract, and extraction time is 1-2 time, and each extraction time is 0.5-2 hour.

A Chinese herbal medicine beverage for strengthening the spleen and nourishing the stomach, prepare by following technique:

With parts by weight, crude drug forms: Semen Lablab Album 3-15 part, Rhizoma Dioscoreae 1-10 part, Poria 3-15 part, Fructus Mume 1-8 part, Concha Ostreae 1-8 part, finger citron sliced 1-8 part, Fructus Hordei Germinatus 1-8 part, Semen Ziziphi Spinosae 3-15 part, Fructus Jujubae 1-8 part, Arillus Longan 1-8 part, Fructus Alpiniae Oxyphyllae 1-8 part, Fructus Mori 1-8 part, Fructus Crataegi 1-8 part, Semen Raphani 1-10 part, Cordyceps militaris (L.) Link. 3-15 part;

Preparation method:

Step 1: Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixing, with water extraction;

Step 2: the extracting solution that Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani and step 1 obtain after water extraction and medicinal residues mix, continuation water extraction; Extracting solution is concentrated obtains concentrated solution A;

Step 3: Cordyceps militaris (L.) Link. extracts with alcoholic solution, extracting solution is concentrated obtains concentrated solution B;

Step 4: merge concentrated solution A, B, add original plasm wine, to be adjusted to alcohol concentration be 30-50% (volumetric concentration) for white sugar, water, sugar content 2-10% (g/ml), gets supernatant after leaving standstill, and filters, to obtain final product.

Further, extracting method described in step 1,2 is decoct one or more modes in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects; Further, extracting method described in step 1,2 is first soak extraction, then reflux, extract; Further, the described soak extraction time is 2-10 hour, and reflux, extract, number of times is 1-2 time, and each extraction time is 0.5-2 hour.

Further, alcoholic solution described in step 3 is the alcoholic solution of 30-80%; Further, described alcoholic solution is 50% alcoholic solution;

Further, extracting method described in step 3 is one or more modes in reflux, extract, soak extraction, supersound extraction or seepage pressure effects; Further, described extracting method is reflux, extract, and extraction time is 1-2 time, and each extraction time is 0.5-2 hour.

Further, alcohol concentration described in step 4 is 32-48%, and sugar content is 3-8%; Further, described alcohol concentration is 35-40%, and sugar content is 4-6%; Further, described alcohol concentration is 38%, and sugar content is 5%.

Chinese medicine composition of the present invention has the effect of obvious improving water flood, diet and constipation, and has and significantly promote alcohol metabolism effect.

Detailed description of the invention

Different components comparitive study

Experimental agents:

Prescription 1: Semen Lablab Album 4g, Rhizoma Dioscoreae 2g, Poria 4g, Fructus Mume 1g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 1g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 1g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g, Cordyceps militaris (L.) Link. 6g;

Prescription 2: Semen Lablab Album 4g, Rhizoma Dioscoreae 10g, Poria 3g, Fructus Mume 3g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 2g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 2g, Arillus Longan 3g, Fructus Alpiniae Oxyphyllae 3g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g;

Prescription 3: Semen Lablab Album 4g, Rhizoma Dioscoreae 2g, Poria 4g, Fructus Mume 1g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 1g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 1g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g, Cordyceps militaris (L.) Link. 6g, Herba Pogostemonis 5g, Pericarpium Citri tangerinae 3g;

Prescription 4: Semen Lablab Album 4g, Rhizoma Dioscoreae 2g, Poria 4g, Fructus Mume 1g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 1g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 1g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g, Cordyceps militaris (L.) Link. 6g, Amylum Puerariae Radicis 3g, Rhizoma Zingiberis Recens 4g;

Preparation method: get crude drug in proportion, Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixing, with water extraction; Extracting solution and the medicinal residues of all the other medical materials except Cordyceps militaris (L.) Link. and Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mix, and with water extraction, extracting solution is concentrated obtains concentrated solution A; Cordyceps militaris (L.) Link. extracts with alcoholic solution, and extracting solution is concentrated obtains concentrated solution B; Merge concentrated solution A, B, adding original plasm wine, white sugar and water, to be adjusted to alcohol concentration be 38% (volumetric concentration), and sugary is 5% (g/ml), prepares health promoting beverage.

Experimental result: trier is the adult male that 40 love is drunk, the age 25-40 year between, trier's good wine at ordinary times, appetite is strong, constipation of getting angry, easily sick, insomnia and dreamful sleep.

Trial method: the health promoting beverage prepared by prescription 1-4 gives 10 triers respectively and takes, each one bottle of noon, evening, 125ml/ bottle, two weeks on probation.Pay a return visit trial effect with questionnaire form, investigate beverage mouthfeel, to the improvement of sleep, appetite, constipation and untoward reaction (occurring dizzy phenomenon of awaking from a drunken sleep), add up percentage rate, the results are shown in Table 1.

Table 1 different components comparitive study result

	Taste good	Sleep improvement	Appetite is improved	Constipation improves	To awake from a drunken sleep dizzy phenomenon
						Prescription 1	90％	80％	80％	90％	10％
Prescription 2	70％	60％	80％	60％	30％
						Prescription 3	80％	40％	60％	60％	40％
Prescription 4	70％	40％	70％	40％	40％

Result shows, prescription 1 Be very effective in improving water flood, diet and constipation is better than prescription 2,3,4; And mouthfeel is good, untoward reaction is little.

Preparation method is investigated

Prescription: Semen Lablab Album 4g, Rhizoma Dioscoreae 2g, Poria 4g, Fructus Mume 1g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 1g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 1g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g, Cordyceps militaris (L.) Link. 6g;

Preparation method 1:

Step 1: Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixing, with water extraction;

Step 2: the extracting solution of Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani and step 1 and medicinal residues are mixed, with water extraction; Extracting solution is concentrated obtains concentrated solution A;

Step 3: Cordyceps militaris (L.) Link. extracts with alcoholic solution, extracting solution is concentrated obtains concentrated solution B;

Step 4: merge concentrated solution A, B, obtain Chinese medicine composition.

Preparation method 2:

Step 1: Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae, Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani mixing, with water extraction; Extracting solution is concentrated obtains concentrated solution A;

Step 2: Cordyceps militaris (L.) Link. extracts with alcoholic solution, extracting solution is concentrated obtains concentrated solution B;

Step 3: merge concentrated solution A, B, obtain Chinese medicine composition.

Above two kinds of concentrated solutions extracted slowly being added while stirring original plasm wine, white sugar and water, to be adjusted to alcohol concentration be 38% (volumetric concentration), and sugary is 5% (g/ml).

Result on trial:

Trier is the adult male that 20 love is drunk, the age 25-40 year between, trier's good wine at ordinary times, appetite is strong, constipation of getting angry, easily sick, insomnia and dreamful sleep.

Trial method: the health promoting beverage two kinds of methods prepared gives 10 triers respectively and takes, noon, evening, each 125ml, tried out two weeks.Pay a return visit trial effect with questionnaire form, investigate beverage mouthfeel, to the improvement of sleep, appetite, constipation and untoward reaction (occurring dizzy phenomenon of awaking from a drunken sleep), add up percentage rate, the results are shown in Table 2.

Table 2 different preparation method comparitive study result

	Taste good	Sleep improvement	Appetite is improved	Constipation improves	To awake from a drunken sleep dizzy phenomenon
						Preparation method 1	90％	80％	80％	90％	10％
Preparation method 2	80％	60％	80％	0％	20％

Result shows: the health promoting beverage prepared by preparation method 1 at improving water flood, diet, the health promoting beverage that especially constipation aspect successful is prepared higher than preparation method 2; And untoward reaction is little compared with preparation method 2.

EXAMPLE Example 1

A Chinese medicinal health-care beverage for strengthening the spleen and nourishing the stomach, its preparation method comprises the following steps:

Crude drug forms: Semen Lablab Album 4g, Rhizoma Dioscoreae 2g, Poria 4g, Fructus Mume 1g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 1g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 1g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g, Cordyceps militaris (L.) Link. 6g;

Preparation method:

Step 1: get Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae in proportion, pulverizes, adds 10 times of water, soak 2 hours, heating and refluxing extraction half an hour;

Step 2: get Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani in proportion, add 10 times of water, soak 2 hours, mix with the extracting solution of step 1 after water extraction and medicinal residues, heating and refluxing extraction 2 hours, filter, obtain extracting solution A and medicinal residues; Medicinal residues add 8 times of water, heated and boiled, filter, obtain extracting solution B; Merge extractive liquid, A, B, at 65-75 DEG C, concentrating under reduced pressure, obtains concentrated solution A;

Step 3: get Cordyceps militaris (L.) Link. in proportion, adds 50% ethanol of 10 times amount, at 60-65 DEG C, and reflux, extract, 2 hours; Filter, obtain extracting solution C and medicinal residues; Medicinal residues add 50% medicinal alcohol of 8 times amount, at 60-65 DEG C, and reduced-pressure backflow 1.5 hours; Filter, obtain extracting solution D; Merge extractive liquid, C, D, at 60-65 DEG C, concentrating under reduced pressure, obtains concentrated solution B;

Step 4: merge concentrated solution A, B, slowly adding original plasm wine, white sugar and water while stirring, to be adjusted to alcohol concentration be 38% (volumetric concentration), and sugary is 5% (g/ml), airtight cold preservation 3 days, get supernatant, microporous filter membrane filtration, obtains filtrate;

Step 5: filtrate, through fine setting, confirms alcoholic strength and pol, selects vial fill, to obtain final product.

Specification: every bottle of 125ml;

Usage and dosage: the morning, noon and afternoon respectively once, each 125ml.

Effect experimental:

1, beverage of the present invention is on Mouse Weight change and the impact of mortality rate

Laboratory animal: 75 body weight are close, the mice be in a good state of health, its empty group 25, matched group 25, experimental group 25;

Experimental agents: prepare by embodiment 1;

Experimental technique: give respectively blank group, matched group and experimental group by body weight 0.25ml/20g, gavage the health promoting beverage of water, 38%vol common wine (not pastille) and embodiment 1 preparation every day respectively once.Gavage 1 month continuously, observe the body weight of mice, mortality rate and gavage the change of rear blood alcohol concentration for the last time.

Experimental result: Mouse Weight change and mortality statistics are as table 3:

Table 3 beverage of the present invention is on Mouse Weight change and the impact of mortality rate

Note: * P ﹤ 0.05, P value is less, more has reason to think and there are differences between contrast groups.

Result shows: drinking has certain detrimental effect to the physiological function of mice, but drinking health promoting beverage of the present invention, to compare common wine infringement less.This is inseparable with health-care effect of the present invention.

2, beverage of the present invention is on the impact of Mouse Blood determining alcohol

Experimental technique is with " 1, beverage of the present invention on Mouse Weight change and the impact of mortality rate "

Take to extract eyeball blood sampling and detect blood alcohol concentration: randomly draw 3-4 mice excision eyeball in different time sections and get blood mixing.Acquisition time be fill with after drinking 30,60,90,120,150,180min, blood sampling more than 1ml in anticoagulant heparin pipe, 4000r/min, centrifugal 5min gets supernatant, uses gas Chromatographic Determination ethanol content.Result is as table 4:

Table 4 beverage of the present invention is on the impact of Mouse Blood determining alcohol

Result shows: the mice gavaging beverage of the present invention, and the absorption for wine shows and absorbs soon, and also fast feature is eliminated in metabolism.This and the present invention have strengthening the spleen and nourishing the stomach, and the effect strengthening transporting has much relations.

Embodiment 2

A Chinese medicinal health-care beverage for strengthening the spleen and nourishing the stomach, its preparation method comprises the steps:

Crude drug forms: Semen Lablab Album 3g, Rhizoma Dioscoreae 10g, Poria 3g, Fructus Mume 8g, Concha Ostreae 2g, finger citron sliced 8g, Fructus Hordei Germinatus 2g, Semen Ziziphi Spinosae 15g, Fructus Jujubae 1g, Arillus Longan 8g, Fructus Alpiniae Oxyphyllae 1g, Fructus Mori 8g, Fructus Crataegi 1g, Semen Raphani 10g, Cordyceps militaris (L.) Link. 3g;

Preparation method:

Step 1: get Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae in proportion, pulverizes, adds 12 times of water, soak 5 hours, supersound extraction half an hour;

Step 2: get Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani in proportion, add 10 times of water, soak 5 hours, mix with the extracting solution of step 1 and medicinal residues, supersound extraction twice, each 1.5 hours, merge extractive liquid, at 65-75 DEG C, concentrating under reduced pressure, obtains concentrated solution A;

Step 3: get Cordyceps militaris (L.) Link. in proportion, adds 70% ethanol of 8 times amount, supersound extraction twice, each 1.5 hours, merge extractive liquid, and at 60-65 DEG C, concentrating under reduced pressure, obtains concentrated solution B;

Step 4: merge concentrated solution A, B, slowly adding original plasm wine, white sugar and water while stirring, to be adjusted to alcohol concentration be 38% (volumetric concentration), and sugary is 5% (g/ml), airtight cold preservation 3 days, get supernatant, microporous filter membrane filtration, obtains filtrate;

Step 5: filtrate, through fine setting, confirms alcoholic strength and pol, selects vial fill, to obtain final product.

Specification: every bottle of 125ml;

Usage and dosage: the morning, noon and afternoon respectively once, each 125ml.

Embodiment 3

A Chinese medicinal health-care beverage for strengthening the spleen and nourishing the stomach, its preparation method comprises the steps:

Crude drug forms: Semen Lablab Album 15g, Rhizoma Dioscoreae 1g, Poria 15g, Fructus Mume 1g, Concha Ostreae 8g, finger citron sliced 1g, Fructus Hordei Germinatus 8g, Semen Ziziphi Spinosae 3g, Fructus Jujubae 8g, Arillus Longan 1g, Fructus Alpiniae Oxyphyllae 8g, Fructus Mori 1g, Fructus Crataegi 8g, Semen Raphani 1g, Cordyceps militaris (L.) Link. 12g;

Preparation method:

Step 1: get Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae in proportion, pulverizes, adds 8 times of water, soak 3 hours, heating and refluxing extraction half an hour;

Step 2: get Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani in proportion, add 8 times of water, soak 3 hours, mix with the extracting solution of step 1 and medicinal residues, seepage pressure effects 12 hours, filter, extracting solution is concentrating under reduced pressure at 65-75 DEG C, obtains concentrated solution A;

Step 3: get Cordyceps militaris (L.) Link. in proportion, adds 40% ethanol of 12 times amount, at 60-65 DEG C, and reflux, extract, twice, each 1.5 hours, merge extractive liquid, at 60-65 DEG C, concentrating under reduced pressure, obtains concentrated solution B;

Step 4: merge concentrated solution A, B, slowly adding original plasm wine, white sugar and water while stirring, to be adjusted to alcohol concentration be 42% (volumetric concentration), and sugary is 3% (g/ml), airtight cold preservation 3 days, get supernatant, microporous filter membrane filtration, obtains filtrate;

Step 5: filtrate, through fine setting, confirms alcoholic strength and pol, selects vial fill, to obtain final product.

Specification: every bottle of 125ml;

Usage and dosage: the morning, noon and afternoon respectively once, each 125ml.

Embodiment 4

A Chinese medicine composition for strengthening the spleen and nourishing the stomach, prepare as follows:

Crude drug forms: Semen Lablab Album 5g, Rhizoma Dioscoreae 7g, Poria 5g, Fructus Mume 6g, Concha Ostreae 3g, finger citron sliced 6g, Fructus Hordei Germinatus 3g, Semen Ziziphi Spinosae 12g, Fructus Jujubae 2g, Arillus Longan 6g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 6g, Fructus Crataegi 1g, Semen Raphani 7g, Cordyceps militaris (L.) Link. 5g;

Preparation method: get Cordyceps militaris (L.) Link. in proportion, add 10 times amount 65% alcoholic solution reflux, extract, twice, each 1 hour, merge extractive liquid, concentrating under reduced pressure obtains concentrated solution A; Get all the other crude drug except Cordyceps militaris (L.) Link. in proportion, add 12 times of water supersound extraction twice, each 1.5 hours, merge extractive liquid, concentrating under reduced pressure, obtains concentrated solution B; Concentrated solution A, B are mixed, adds water to the clear paste that relative density is 1.06 (50 ~ 60 DEG C), add adjuvant, make oral liquid.

Embodiment 5

A Chinese medicine composition for strengthening the spleen and nourishing the stomach, prepare as follows:

Crude drug forms: Semen Lablab Album 12g, Rhizoma Dioscoreae 3g, Poria 12g, Fructus Mume 3g, Concha Ostreae 6g, finger citron sliced 3g, Fructus Hordei Germinatus 6g, Semen Ziziphi Spinosae 5g, Fructus Jujubae 6g, Arillus Longan 3g, Fructus Alpiniae Oxyphyllae 6g, Fructus Mori 3g, Fructus Crataegi 6g, Semen Raphani 3g, Cordyceps militaris (L.) Link. 10g;

Preparation method: get Cordyceps militaris (L.) Link. in proportion, add 8 times amount 75% alcoholic solution supersound extraction twice, each 1 hour, merge extractive liquid, concentrating under reduced pressure obtains concentrated solution A; Get all the other crude drug except Cordyceps militaris (L.) Link. in proportion, add 10 times of water backflows twice, each 1.5 hours, merge extractive liquid, concentrating under reduced pressure, obtains concentrated solution B; Concentrated solution A, B are mixed, drying under reduced pressure, is ground into fine powder, adds customary adjuvant, mixing; Dry-pressing is granulated, and tabletting, to obtain final product.

Embodiment 6

A Chinese medicine composition for strengthening the spleen and nourishing the stomach, preparation method comprises the following steps:

Crude drug: Semen Lablab Album 4g, Rhizoma Dioscoreae 2g, Poria 4g, Fructus Mume 1g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 1g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 1g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g, Cordyceps militaris (L.) Link. 6g;

Preparation method:

Get Cordyceps militaris (L.) Link. in proportion, add 12 times amount 55% alcoholic solution supersound extraction twice, each 1 hour, merge extractive liquid, concentrating under reduced pressure obtains concentrated solution A; Get all the other crude drug except Cordyceps militaris (L.) Link. in proportion, add 12 times of soak by water twice, each 2 hours, merge extractive liquid, concentrating under reduced pressure, obtains concentrated solution B; Concentrated solution A, B are mixed, drying under reduced pressure, is ground into fine powder, adds adjuvant, mixing; Dry-pressing is granulated, and to obtain final product.

Effect test

The data statistics of this product beta test:

The adult male that trier's 90 love are drunk, the age 25-40 year between, trier's good wine at ordinary times, appetite is strong, constipation of getting angry, easily sick, insomnia and dreamful sleep.

Trial method: experimenter is equally divided into three groups, the health promoting beverage prepared by embodiment 1-3 gives trier and takes, noon, each one bottle of evening, 125ml/ bottle, two weeks on probation.Pay a return visit trial effect with questionnaire form, investigate beverage mouthfeel, to the improvement of sleep, appetite, constipation and untoward reaction (occurring dizzy phenomenon of awaking from a drunken sleep), add up percentage rate, result is as following table 5:

The statistical effect of table 5 embodiment 1-3 product

Embodiment 1 product	Taste good	Sleep improvement	Appetite is improved	Constipation improves	To awake from a drunken sleep dizzy phenomenon
						Number of users	30	30	30	30	30
Effectively/dizzy number	27	24	26	26	3
						Percentage rate	90％	80％	86.7％	86.7％	10.0％
Embodiment 2 product	Taste good	Sleep improvement	Appetite is improved	Stool is improved	To awake from a drunken sleep dizzy phenomenon
						Number of users	30	30	30	30	30
Effectively/dizzy number	26	25	25	24	3
						Percentage rate	86.7％	83.3％	83.3％	80％	10％
Embodiment 3 product	Taste good	Sleep improvement	Appetite is improved	Stool is improved	To awake from a drunken sleep dizzy phenomenon
						Number of users	30	30	30	30	30
Effectively/dizzy number	26	26	25	23	4
						Percentage rate	86.7％	86.7％	83.3％	76.7％	13.3％

Health promoting beverage of the present invention is suitable for adult and takes, and have raising immunity of organisms, invigorating the stomach and promoting digestion, invigorate, the effects such as relieving mental strain and helping sleep, and untoward reaction is little, tries out and not easily occurs dizzy phenomenon of awaking from a drunken sleep.

Claims (10)

1. the Chinese medicine composition of a strengthening the spleen and nourishing the stomach, it is characterized in that, this Chinese medicine composition mainly comprises following crude drug: Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, Concha Ostreae, finger citron sliced, Fructus Hordei Germinatus, Semen Ziziphi Spinosae, Fructus Jujubae, Arillus Longan, Fructus Alpiniae Oxyphyllae, Fructus Mori, Fructus Crataegi, Semen Raphani, Cordyceps militaris (L.) Link..

2. Chinese medicine composition as claimed in claim 1, it is characterized in that, with parts by weight, this traditional Chinese medicinal composition raw materials consists of:

Semen Lablab Album 3-15 part, Rhizoma Dioscoreae 1-10 part, Poria 3-15 part, Fructus Mume 1-8 part, Concha Ostreae 1-8 part, finger citron sliced 1-8 part, Fructus Hordei Germinatus 1-8 part, Semen Ziziphi Spinosae 3-15 part, Fructus Jujubae 1-8 part, Arillus Longan 1-8 part, Fructus Alpiniae Oxyphyllae 1-8 part, Fructus Mori 1-8 part, Fructus Crataegi 1-8 part, Semen Raphani 1-10 part, Cordyceps militaris (L.) Link. 3-15 part.

3. Chinese medicine composition as claimed in claim 2, it is characterized in that, with parts by weight, this traditional Chinese medicinal composition raw materials consists of:

Semen Lablab Album 3-12 part, Rhizoma Dioscoreae 1-7 part, Poria 3-12 part, Fructus Mume 1-6 part, Concha Ostreae 1-6 part, finger citron sliced 1-6 part, Fructus Hordei Germinatus 1-6 part, Semen Ziziphi Spinosae 3-12 part, Fructus Jujubae 1-6 part, Arillus Longan 1-6 part, Fructus Alpiniae Oxyphyllae 1-6 part, Fructus Mori 1-6 part, Fructus Crataegi 1-6 part, Semen Raphani 1-7 part, Cordyceps militaris (L.) Link. 3-12 part.

4. Chinese medicine composition as claimed in claim 3, it is characterized in that, with parts by weight, this traditional Chinese medicinal composition raw materials consists of:

Semen Lablab Album 3-8 part, Rhizoma Dioscoreae 1-5 part, Poria 3-8 part, Fructus Mume 1-4 part, Concha Ostreae 1-4 part, finger citron sliced 1-4 part, Fructus Hordei Germinatus 1-4 part, Semen Ziziphi Spinosae 3-8 part, Fructus Jujubae 1-4 part, Arillus Longan 1-4 part, Fructus Alpiniae Oxyphyllae 1-4 part, Fructus Mori 1-4 part, Fructus Crataegi 1-4 part, Semen Raphani 1-5 part, Cordyceps militaris (L.) Link. 3-8 part.

5. Chinese medicine composition as claimed in claim 3, it is characterized in that, with parts by weight, this traditional Chinese medicinal composition raw materials consists of:

Semen Lablab Album 4 parts, Rhizoma Dioscoreae 2 parts, 4 parts, Poria, Fructus Mume 1 part, Concha Ostreae 1 part, finger citron sliced 1 part, 1 part, Fructus Hordei Germinatus, Semen Ziziphi Spinosae 4 parts, 1 part, Fructus Jujubae, Arillus Longan 2 parts, Fructus Alpiniae Oxyphyllae 2 parts, Fructus Mori 2 parts, Fructus Crataegi 2 parts, Semen Raphani 2 parts, Cordyceps militaris (L.) Link. 6 parts.

6. Chinese medicine composition as described in any one of claim 1-5, is characterized in that, described compositions is prepared into health promoting beverage, oral liquid, granule, tablet, capsule, powder according to a conventional method.

7. the preparation method of Chinese medicine composition as described in any one of claim 1-5, it is characterized in that, the preparation method of this Chinese medicine composition comprises:

Step 1: Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixing, with water extraction;

Step 2: the extracting solution that Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani and step 1 obtain after water extraction and medicinal residues mix, continuation water extraction; Extracting solution is concentrated obtains concentrated solution A;

Step 3: Cordyceps militaris (L.) Link. extracts with alcoholic solution, extracting solution is concentrated obtains concentrated solution B;

Step 4: merge concentrated solution A, B, obtain Chinese medicine composition.

8. preparation method as claimed in claim 7, is characterized in that, extracting method described in step 1,2 is decoct one or more modes in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects; Extraction time is 2-10 hour, and extraction time is 1-3 time.

9. as described in any one of claim 1-5, Chinese medicine composition is being prepared improving water flood, treatment constipation or is being promoted the application in the health product of alcohol metabolism or medicine.

10. a Chinese herbal medicine beverage for strengthening the spleen and nourishing the stomach, is characterized in that, described beverage is prepared as follows:

With parts by weight, crude drug forms: Semen Lablab Album 3-15 part, Rhizoma Dioscoreae 1-10 part, Poria 3-15 part, Fructus Mume 1-8 part, Concha Ostreae 1-8 part, finger citron sliced 1-8 part, Fructus Hordei Germinatus 1-8 part, Semen Ziziphi Spinosae 3-15 part, Fructus Jujubae 1-8 part, Arillus Longan 1-8 part, Fructus Alpiniae Oxyphyllae 1-8 part, Fructus Mori 1-8 part, Fructus Crataegi 1-8 part, Semen Raphani 1-10 part, Cordyceps militaris (L.) Link. 3-15 part;

Preparation method:

Step 1: Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixing, with water extraction;

Step 2: the extracting solution that Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani and step 1 obtain after water extraction and medicinal residues mix, continuation water extraction; Extracting solution is concentrated obtains concentrated solution A;

Step 3: Cordyceps militaris (L.) Link. extracts with alcoholic solution, extracting solution is concentrated obtains concentrated solution B;

Step 4: merge concentrated solution A, B, add original plasm wine, to be adjusted to alcohol concentration be 30-50% (volumetric concentration) for white sugar, water, sugar content 2-10% (g/ml), gets supernatant after leaving standstill, and filters, to obtain final product.