CN105307634B - 含有改性瓜尔胶的药物软明胶胶囊剂型 - Google Patents
含有改性瓜尔胶的药物软明胶胶囊剂型 Download PDFInfo
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- CN105307634B CN105307634B CN201480022804.XA CN201480022804A CN105307634B CN 105307634 B CN105307634 B CN 105307634B CN 201480022804 A CN201480022804 A CN 201480022804A CN 105307634 B CN105307634 B CN 105307634B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
%水 | 粘度(Pa s) | Log粘度 |
0 | 156.15 | 2.22 |
10 | 56.72 | 1.75 |
20 | 26.7 | 1.43 |
%水 | 粘度(Pa s) | Log粘度 |
0 | 22.57 | 1.35 |
10 | 16.14 | 1.21 |
20 | 11.55 | 1.06 |
%水 | 粘度(Pa s) | Log粘度 |
0 | 39.56 | 1.60 |
10 | 85.47 | 1.93 |
20 | 52.25 | 1.72 |
30 | 22.63 | 1.36 |
填充物材料 | 粘度(Pa s) | Log粘度 |
包封前 | 24.77 | 1.39 |
包封后 | 63.66 | 1.80 |
Claims (17)
Priority Applications (1)
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CN202010063854.XA CN111374959A (zh) | 2013-03-15 | 2014-03-14 | 含有改性瓜尔胶的药物软明胶胶囊剂型 |
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US201361794906P | 2013-03-15 | 2013-03-15 | |
US61/794,906 | 2013-03-15 | ||
PCT/US2014/027145 WO2014152269A1 (en) | 2013-03-15 | 2014-03-14 | Pharmaceutical soft gelatin capsule dosage form with modified guar gum |
Related Child Applications (1)
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CN202010063854.XA Division CN111374959A (zh) | 2013-03-15 | 2014-03-14 | 含有改性瓜尔胶的药物软明胶胶囊剂型 |
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CN105307634A CN105307634A (zh) | 2016-02-03 |
CN105307634B true CN105307634B (zh) | 2020-03-10 |
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CN201480022804.XA Active CN105307634B (zh) | 2013-03-15 | 2014-03-14 | 含有改性瓜尔胶的药物软明胶胶囊剂型 |
CN202010063854.XA Pending CN111374959A (zh) | 2013-03-15 | 2014-03-14 | 含有改性瓜尔胶的药物软明胶胶囊剂型 |
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Country Status (14)
Country | Link |
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US (3) | US9795569B2 (zh) |
EP (2) | EP3187170A1 (zh) |
JP (3) | JP6335270B2 (zh) |
KR (1) | KR20150131070A (zh) |
CN (2) | CN105307634B (zh) |
AU (2) | AU2014239994B2 (zh) |
BR (1) | BR112015022946A8 (zh) |
CA (1) | CA2906633C (zh) |
ES (1) | ES2619121T3 (zh) |
HK (1) | HK1218622A1 (zh) |
IL (1) | IL241377B (zh) |
MX (2) | MX364440B (zh) |
RU (1) | RU2676480C2 (zh) |
WO (1) | WO2014152269A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105307634B (zh) * | 2013-03-15 | 2020-03-10 | 沃纳奇尔科特有限责任公司 | 含有改性瓜尔胶的药物软明胶胶囊剂型 |
AU2016238337B2 (en) | 2015-03-26 | 2020-08-13 | Patheon Softgels Inc. | Liquisoft capsules |
JP2017214299A (ja) * | 2016-05-30 | 2017-12-07 | ライオン株式会社 | 半固形製剤及びその製造方法 |
WO2022101828A1 (en) * | 2020-11-13 | 2022-05-19 | Pfizer Inc. | Talazoparib soft gelatin capsule dosage form |
CN116531444B (zh) * | 2023-07-06 | 2023-10-10 | 健码制药(广东)有限公司 | 镇咳清肺软胶囊及其制备工艺 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0770384A1 (en) * | 1995-10-27 | 1997-05-02 | Montefarmaco S.p.A. | Solid, anhydrous, pharmaceutical compositions for vaginal use |
CN1198665A (zh) * | 1995-10-05 | 1998-11-11 | 伊诺托拉实验室 | 用于***干燥的局部激素疗法的单位盖仑制剂 |
US5945398A (en) * | 1997-09-08 | 1999-08-31 | Panacea Biotec Limited | Pharmaceutical compositions containing cyclosporin |
EP1527169A2 (fr) * | 2002-08-07 | 2005-05-04 | Ricarimpex | Extraits de sangsues pour stents |
CN101360485A (zh) * | 2005-10-26 | 2009-02-04 | 班纳制药公司 | 作为胶囊填充物的基于亲水性载体的双重控释基质*** |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4708834A (en) | 1986-05-01 | 1987-11-24 | Pharmacaps, Inc. | Preparation of gelatin-encapsulated controlled release composition |
US5102666A (en) | 1990-09-11 | 1992-04-07 | Oramed, Inc. | Calcium polycarbophil controlled release composition and method |
WO1997033568A1 (en) | 1996-03-12 | 1997-09-18 | Novartis Ag | Filled gelatin capsules having a reduced degree of cross-linking |
US5919481A (en) * | 1996-06-28 | 1999-07-06 | Ncneil-Ppc, Inc. | Fill material for soft gelatin pharmaceutical dosage form |
US6024980A (en) * | 1996-06-28 | 2000-02-15 | Mcneil-Ppc, Inc. | Multiphase soft gelatin dosage form |
US5989535A (en) | 1997-08-15 | 1999-11-23 | Soma Technologies | Polymeric bioadhesive emulsions and suspensions and methods of treatment |
US6187747B1 (en) * | 1997-09-08 | 2001-02-13 | Panacea Biotech Limited | Pharmaceutical composition comprising cyclosporin |
US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
US6251426B1 (en) * | 1999-09-02 | 2001-06-26 | Banner Pharmacaps, Inc. | Ibuprofen-containing softgels |
US20040131670A1 (en) | 2001-04-17 | 2004-07-08 | Ping Gao | Pellicle-resistant gelatin capsule |
EP1599485A2 (en) | 2003-02-18 | 2005-11-30 | Ranbaxy Laboratories, Ltd. | Podophyllotoxin derivatives as antitumor agents |
KR100570450B1 (ko) * | 2003-09-25 | 2006-04-12 | 한국유나이티드제약 주식회사 | 가용성 로바스타틴의 연질캡슐제 조성물 및 그의 제조방법 |
US20050142185A1 (en) * | 2003-12-29 | 2005-06-30 | Beleno Alfredo B. | Softgel formulations of bisphosphonates bone resorption inhibitors |
JP2007517877A (ja) | 2004-01-15 | 2007-07-05 | ワーナー・チルコット・カンパニー・インコーポレーテッド | エストラジオールのジ−ステロイド型プロドラッグ |
WO2005070950A1 (en) | 2004-01-15 | 2005-08-04 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of ethinyl estradiol |
US20060110415A1 (en) * | 2004-11-22 | 2006-05-25 | Bioderm Research | Topical Delivery System for Cosmetic and Pharmaceutical Agents |
US7485323B2 (en) | 2005-05-31 | 2009-02-03 | Gelita Ag | Process for making a low molecular weight gelatine hydrolysate and gelatine hydrolysate compositions |
US10016442B2 (en) | 2005-06-16 | 2018-07-10 | Allergan Pharmaceuticals International Limited | Estrogen compositions for vaginal administration |
EP1910401A2 (en) | 2005-07-12 | 2008-04-16 | Warner Chilcott Company, Inc. | 3-ester prodrugs of ethynylestradiol |
EP1910402A2 (en) | 2005-07-12 | 2008-04-16 | Warner Chilcott Company, Inc. | 3-ester prodrugs of estradiol |
US7468970B2 (en) | 2005-10-24 | 2008-12-23 | Honeywell International Inc. | Routing of mobile agents in a network |
US20070104778A1 (en) | 2005-11-07 | 2007-05-10 | Hongxia Zeng | Controlled-release emulsion compositions |
WO2007066837A1 (en) | 2005-12-06 | 2007-06-14 | Lg Household & Health Care Ltd. | Delivery system for tooth whitening component using in situ gelling |
JP2009526040A (ja) | 2006-02-10 | 2009-07-16 | エル・ジー ハウスホールド アンド ヘルスケア リミティッド | 同時溶解及びゲル化錠剤型の口腔衛生組成物 |
US20080090569A1 (en) | 2006-10-13 | 2008-04-17 | At&T Knowledge Ventures, L.P. | Method and apparatus for performing signal processing in an ip multimedia subsystem network |
US20080122993A1 (en) | 2006-11-29 | 2008-05-29 | Sanyo Electric Co., Ltd. | Television image receiver |
BRPI0807807A2 (pt) | 2007-01-25 | 2014-06-17 | Panacea Biotec Ltd | " composição farmacêutica de liberação modificada e um processo para fabricar a mesma ". |
WO2008122993A1 (en) | 2007-04-09 | 2008-10-16 | Panacea Biotec Limited | Controlled release formulation of coated microparticles |
CN101971130A (zh) | 2008-03-26 | 2011-02-09 | 十字科技股份有限公司 | 光学指向装置及具有该光学指向装置的便携式电子装置 |
CN101474167A (zh) * | 2009-01-23 | 2009-07-08 | 西安德天药业股份有限公司 | ******用胶囊的制备方法 |
US20110003000A1 (en) | 2009-07-06 | 2011-01-06 | Femmepharma Holding Company, Inc. | Transvaginal Delivery of Drugs |
WO2011018800A2 (en) | 2009-08-13 | 2011-02-17 | Fdc Limited | A novel in-situ gel forming solution for ocular drug delivery |
CN105307634B (zh) * | 2013-03-15 | 2020-03-10 | 沃纳奇尔科特有限责任公司 | 含有改性瓜尔胶的药物软明胶胶囊剂型 |
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- 2014-03-14 BR BR112015022946A patent/BR112015022946A8/pt not_active Application Discontinuation
- 2014-03-14 EP EP16205027.2A patent/EP3187170A1/en not_active Withdrawn
- 2014-03-14 WO PCT/US2014/027145 patent/WO2014152269A1/en active Application Filing
- 2014-03-14 CN CN202010063854.XA patent/CN111374959A/zh active Pending
- 2014-03-14 JP JP2016502347A patent/JP6335270B2/ja active Active
- 2014-03-14 MX MX2015012057A patent/MX364440B/es active IP Right Grant
- 2014-03-14 KR KR1020157026413A patent/KR20150131070A/ko not_active Application Discontinuation
- 2014-03-14 CA CA2906633A patent/CA2906633C/en active Active
- 2014-03-14 ES ES14719974.9T patent/ES2619121T3/es active Active
- 2014-03-14 AU AU2014239994A patent/AU2014239994B2/en active Active
- 2014-03-14 US US14/210,680 patent/US9795569B2/en active Active
- 2014-03-14 EP EP14719974.9A patent/EP2950781B1/en active Active
- 2014-03-14 RU RU2015137612A patent/RU2676480C2/ru active
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- 2015-09-09 IL IL241377A patent/IL241377B/en active IP Right Grant
- 2015-09-09 MX MX2019004554A patent/MX2019004554A/es unknown
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1198665A (zh) * | 1995-10-05 | 1998-11-11 | 伊诺托拉实验室 | 用于***干燥的局部激素疗法的单位盖仑制剂 |
EP0770384A1 (en) * | 1995-10-27 | 1997-05-02 | Montefarmaco S.p.A. | Solid, anhydrous, pharmaceutical compositions for vaginal use |
US5945398A (en) * | 1997-09-08 | 1999-08-31 | Panacea Biotec Limited | Pharmaceutical compositions containing cyclosporin |
EP1527169A2 (fr) * | 2002-08-07 | 2005-05-04 | Ricarimpex | Extraits de sangsues pour stents |
CN101360485A (zh) * | 2005-10-26 | 2009-02-04 | 班纳制药公司 | 作为胶囊填充物的基于亲水性载体的双重控释基质*** |
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