CN105267676A - Nursing medicine liquid for treating burns and scalds and method for preparing nursing medicine liquid - Google Patents
Nursing medicine liquid for treating burns and scalds and method for preparing nursing medicine liquid Download PDFInfo
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Abstract
The invention discloses nursing medicine liquid for treating burns and scalds and a method for preparing the nursing medicine liquid. The nursing medicine liquid comprises Chinese and western medicine components including, by weight, 50-80 parts of white sesame oil, 4-10 parts of nacre mother of pearl, 2-12 parts of lithospermum purpurocaeruleum, 2-9 parts of borneol, 5-10 parts of common bletilla pseudobulb, 10-15 parts of sanguisorba officinalis, 20-25 parts of rhubarb, 5-15 parts of angelica sinensis, 8-12 parts of radix sophorae subprostratae, 10-15 parts of rhizoma paridis, 15-20 parts of fructus cnidii, 5-10 parts of fructus kochiae, 12-15 parts of honeysuckle, 5-10 parts of white cinnamon, 5-8 parts of peppermint, 5-10 parts of radix ampelopsis, 5-8 parts of panax notoginseng, 5-8 parts of pearl powder, 0.3-0.5 part of honey, 0.1-0.2 part of chlorhexidine acetate, 0.1-0.2 part of miconazole nitrate, 0.2-0.5 part of amoxicillin, 0.1-0.2 part of cefalexin and 0.2-0.5 part of furazolidone powder. The nursing medicine liquid and the method have the advantages that the nursing medicine liquid can be easily and feasibly prepared and is low in cost; the nursing medicine liquid has few side effects and is inexpensive, and the burns and scalds can be effectively treated by the aid of the nursing medicine liquid.
Description
Technical field
The invention belongs to drug world, be specifically related to a kind of nursing medicinal liquid being used for the treatment of burn and scald and preparation method thereof.
Background technology
Along with the continuous expansion of social life extension, the Preventing knowledge of empyrosis is failed universal in time, and injured crowd rises year by year.5000-10000 people are about had to suffer various burn and scald in various degree in annual million people, scald in the majority with high-temp liquid in daily life, because each electric appliances, a large amount of of chemical substance popularize, burned patient is in the trend risen, although the Therapeutic Method of burn and scald is a lot of at present, but therapeutic effect is all not ideal enough, most of hospitals need to carry out doing isolate, skin grafting, treatment cycle is longer, expense is also higher, easily makes patient's scar, and what have causes functional disorder, even infect into pyemia, cause infectious dead danger.
The factors such as burn and scald is physics, chemistry, radioactivity act on a kind of and complicated traumatic disease that body causes.In therapeutic process exist have an intense pain, necrosis progrediens, easy infection, cicatrix four problems.Sell Chinese medicine preparation or the Western medicine of use in the market, in treatment burn and scald process all Shortcomings in, the pain relieving of simple use Chinese medicine preparation is slow and antibacterial effect is poor, the shortcoming of indolence, and Western medicine easily produces the shortcomings such as cicatrix, the burn and scald anti-infectives used in current Western medicine mostly, cause Bacterial Drug Resistance of Patients to raise because of life-time service, anti-infection effect is not good enough, how to solve bacterial resistance sex chromosome mosaicism after burn and scald, becomes a great problem of current burn and scald treatment yet.
Summary of the invention
For solving the problem, the invention provides a kind of nursing medicinal liquid being used for the treatment of burn and scald and preparation method thereof, this nursing medicinal liquid Chinese and Western combines, existing definite curative effect, clinical symptoms, few side effects, low price can be improved preferably again, can extraordinary treatment burn and scald, without the need to carrying out isolating, without the need to carrying out skin grafting, treatment cycle is short in use procedure, not easy infection, more preventing from scar or stay cicatrix less after, and this its preparation method is simple, cost is low.
The present invention is a kind of nursing medicinal liquid being used for the treatment of burn and scald for solving the problems of the technologies described above adopted technical scheme, it comprises Chinese medicine and western medicine composition, it is characterized in that this nursing medicinal liquid is grouped into by following one-tenth by weight: the Radix Angelicae Dahuricae Oleum Sesami of 50 ~ 80 parts, the Concha Margaritifera of 4 ~ 10 parts, the Radix Arnebiae (Radix Lithospermi) of 2 ~ 12 parts, the Borneolum Syntheticum of 2 ~ 9 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 5 ~ 10 parts, the Radix Sanguisorbae of 10 ~ 15 parts, the Radix Et Rhizoma Rhei of 20 ~ 25 parts, the Radix Angelicae Sinensis of 5 ~ 15 parts, the rock Radix Sophorae Flavescentis of 8 ~ 12 parts, the Typhonium divaricatum (L.) Decne of 10 ~ 15 parts, the Fructus Cnidii of 15 ~ 20 parts, the fructus kochiae of 5 ~ 10 parts, the Flos Lonicerae of 12 ~ 15 parts, the white osmanthus of 5 ~ 10 parts, the Herba Menthae of 5 ~ 8 parts, the Radix Ampelopsis of 5 ~ 10 parts, the Radix Notoginseng of 5 ~ 8 parts, the Margarita powder of 5 ~ 8 parts, the Mel of 0.3 ~ 0.5 part, the chlorhexidine acetate of 0.1 ~ 0.2 part, the miconazole nitrate of 0.1 ~ 0.2 part, the amoxicillin of 0.2 ~ 0.5 part, the furazolidone powder of the cefalexin of 0.1 ~ 0.2 part and 0.2 ~ 0.5 part.
Preferably, this nursing medicinal liquid being used for the treatment of burn and scald comprises the Radix Angelicae Dahuricae Oleum Sesami of 60 parts, the Concha Margaritifera of 7 parts, the Radix Arnebiae (Radix Lithospermi) of 7 parts, the Borneolum Syntheticum of 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 8 parts, the Radix Sanguisorbae of 12 parts, the Radix Et Rhizoma Rhei of 22 parts, the Radix Angelicae Sinensis of 10 parts, the rock Radix Sophorae Flavescentis of 10 parts, the Typhonium divaricatum (L.) Decne of 13 parts, the Fructus Cnidii of 18 parts, the fructus kochiae of 7 parts, the Flos Lonicerae of 14 parts, the white osmanthus of 8 parts, the Herba Menthae of 6 parts, the Radix Ampelopsis of 7 parts, the Radix Notoginseng of 7 parts, the Margarita powder of 6 parts, the Mel of 0.4 part, the chlorhexidine acetate of 0.1 part, the miconazole nitrate of 0.2 part, the amoxicillin of 0.4 part, the furazolidone powder of the cefalexin of 0.2 part and 0.2 part.
In addition, a kind ofly prepare the described method being used for the treatment of the nursing medicinal liquid of burn and scald, the method comprises the following steps:
1) rinsing oven dry or the Concha Margaritifera dried, Radix Arnebiae (Radix Lithospermi), Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae and Radix Et Rhizoma Rhei is taken according to above-mentioned weight portion, mix homogeneously, drying 30 ~ 40 minutes at 55 ~ 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 60 ~ 70 mesh sieves; Then at 65 ~ 75 DEG C dry 20 ~ 30 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 40 ~ 60 minutes, then put it in ultrafine crusher the fine powder being ground into 200 ~ 220 mesh sieves, and mix homogeneously; Put into Radix Angelicae Dahuricae Oleum Sesami and stir immersion 2 ~ 3 days, for subsequent use;
2) Radix Angelicae Sinensis of above-mentioned weight portion, Radix Notoginseng, Typhonium divaricatum (L.) Decne and Fructus Cnidii mix homogeneously is taken, drying 15 ~ 20 minutes at 55 ~ 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 70 ~ 80 mesh sieves; Add Radix Angelicae Sinensis, Radix Notoginseng, Typhonium divaricatum (L.) Decne and the weight of Fructus Cnidii and the mass concentration of 2.5 times is that the ethanol of 70 ~ 75% is 50 ~ 60 DEG C of heating, reflux, extract, 3 times, each 1.5 ~ 2.5 hours, by obtained ethanol extract, being concentrated into liquor strength 55 ~ 65 DEG C of heating is 0.3g crude drug/ml, be dried to powder, obtain alcohol extraction xeraphium for subsequent use;
3) fructus kochiae of above-mentioned weight portion, Flos Lonicerae and Bai Gui are added the water of 5 ~ 6 times amount, heated and boiled 2 ~ 3 hours, extract; Add the water of 5 times amount again, heated and boiled 1 ~ 2 hour, extract; Merge extracted twice liquid, filter for subsequent use;
4) Herba Menthae of above-mentioned weight portion and Radix Ampelopsis are cleaned, chopping, mashes, adds the distilled water of 5 ~ 6 times amount, stir, and filters, taking juice, for subsequent use;
5) shredded by the rock Radix Sophorae Flavescentis of above-mentioned weight portion, with steaming with vinegar 2 hours, then add Borneolum Syntheticum, Margarita powder and the Mel of above-mentioned weight portion decocted 2 ~ 5 hours, and use 500 mesh screen, extraction medicinal liquid is for subsequent use;
6) chlorhexidine acetate of above-mentioned weight portion, miconazole nitrate, amoxicillin, cefalexin and furazolidone powder are added conventional debugger agent, pH value is transferred to prescribed limit, for subsequent use;
7) by step 6) reagent modulated joins step 1) in the product of gained, be uniformly mixed, extract medicinal liquid for subsequent use;
8) by step 2 ~ 5) and 7) the product mixing decoction of gained 2 times, 2.5 ~ 3.5 hours first times, second time 1.5 ~ 2.5 hours, use 600 mesh screen, extraction medicinal liquid, for subsequent use;
9) by 8) medicinal liquid of step gained adds PH and debugs agent, and pH value is adjusted to prescribed limit, and capping of bottling afterwards, to obtain final product.
Preferably, 1 part of described raw material weight is 10g.
In above-mentioned either a program preferably, described pH value is 5.3 ~ 5.8.
In above-mentioned either a program preferably, described ultrafine crusher CF air flow super machine.
Wherein,
Radix Angelicae Dahuricae Oleum Sesami: removing toxic substances and promoting granulation, skin moistening pain relieving.
Concha Margaritifera: removing toxic substances and promoting granulation.
Radix Arnebiae (Radix Lithospermi): clearing away heat and cooling blood, rash is detoxified, granulation promoting removing the necrotic tissue.
Radix Notoginseng: dissipating blood stasis stops blooding, subduing swelling and relieving pain.Cure mainly for spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.
Flos Lonicerae: heat-clearing and toxic substances removing, kind removing summer-heat blood poison, dermexanthesis, speckle, pyretic toxicity carbuncle sore.
Herba Menthae: refrigerant, dispel the wind, antiinflammatory, analgesia be antipruritic.
Radix Angelicae Sinensis: have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation, anticancer, anti-ageing anti-old, immune effect.
Rock Radix Sophorae Flavescentis: heat clearing and damp drying; Wind dispelling insecticide.
Typhonium divaricatum (L.) Decne: have heat-clearing and toxic substances removing, reducing swelling and alleviating pain, effect of cool liver arresting convulsion.
Fructus Cnidii: heat clearing and damp drying, dispelling wind for relieving itching.
Fructus kochiae: the lumbus strengthening and the kidney invigorating; Clearing away heat and promoting diuresis; Removing toxic substances
Radix Ampelopsis: heat-clearing and toxic substances removing, removing obstruction for relieving pain, promoting tissue regeneration and ulcer healing.
Margarita powder: removing toxic substances life, skin infection is not held back.There is whitening, control oil, anti-acne, pore cleanser, light speckle, granulation promoting effect.
Mel: have convergence, nutrition and Promotive union effect to wound surface.
Radix Et Rhizoma Rhei, Radix Sanguisorbae, Borneolum Syntheticum have the merit of heat-clearing and toxic substances removing, and pharmacological research confirms can to anti-Staphylococcus aureus, escherichia coli, bacillus pyocyaneus etc.; In antiinflammatory, infection, synergism is had after share.
The Chinese medicines such as Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae, Borneolum Syntheticum have convergence granulation promoting, removing toxic substances sore and the effect of putrefaction-removing granulation-promoting pain relieving, can accelerate wound tissue epithelial growth speed, convergence incrustation, and wound surface is closed early, and the chance of infection is few.
Chlorhexidine acetate can suppress, kill pathogenic microorganism as staphylococcus aureus, bacillus pyocyaneus, Pseudomonas aeruginosa etc.
Miconazole nitrate: most of conk can be suppressed, Blastomyces, tissue milk born of the same parents Pseudomonas present extremely sensitive to it,
cryptococcusgenus, Candida, ball
sporepseudomonas etc. are also responsive to this product.
Amoxicillin, cefalexin, furazolidone powder: bactericidal action is strong.
Beneficial effect of the present invention:
1. this be used for the treatment of burn and scald nursing medicinal liquid painting convenience, short treating period, instant effect, have no side effect and can not drug dependence be formed.
2. nursing medicinal liquid Chinese and Western of the present invention combines, and pain relieving is rapid-action, and healing ability is strong, shortens 1/3rd than the general course for the treatment of; Antiphlogistic antibacterial is good, has inhibitory action to general drug tolerant bacteria, has very strong bacteriostasis especially to bacillus pyocyaneus common in burn and scald, staphylococcus aureus, escherichia coli, Candida albicans.
3. this material composition resource abundance being used for the treatment of the nursing medicinal liquid of burn and scald is guaranteed, and efficiency is high, and economic benefit, social benefit are remarkable.
4. the preparation method being used for the treatment of the nursing medicinal liquid of burn and scald of the present invention is simple, and cost is low, is convenient to promote.
Above-mentioned raw material of Chinese medicine is through to be verified for many years, records and test gained, although their effect is different, but choosing of each Chinese medicine is not random and be, the application is according to the proportioning of each composition of test gained for many years, be not by raw material effect simple superposition of each composition, because the multiple interactivelies such as interpromoting relation in five elements, mutual reinforcement between, mutual restraint between two drugs or the mutual-detoxication may be there is between various raw material of Chinese medicine, and the application have selected above-mentioned raw materials accordingly according to this principle exactly, and the optimum proportioning determined between them, therefore, the application has significant meaning.
Chinese medicine of the present invention shows through safety toxicology test: LD50 is 8800mg/kg, and Toxicological evaluation is actual nontoxic level, has no side effect.
Acute toxicity test
Above-mentioned laboratory sample is made suspension, with the dosage being equivalent to clinical daily dosage 200 times through damaged skin administration time, on the behavioral activity of rat, diet, fur gloss and body weight without impact, at viewing duration, do not find that animal has any toxic reaction.Administration is observed for 15 days, none animal dead.
Long-term toxicity test for animals
By above-mentioned sample with clinical daily dosage 5 times, the long term administration in 2 months of 15 times, 70 times confession rats, the general status, routine blood test, blood parameters, Main Organ Coefficients, important organ organizational structure etc. of rat are had no significant effect.Drug withdrawal detects above-mentioned each index and is showed no obvious abnormalities after 2 weeks.The continuous percutaneous drug delivery of rat 2 months long term toxicity tests show, the present invention is safer, without obvious toxic-side effects in tested dosage range,
Hypersensitive test
High dose group 1.87g crude drug/kg of the present invention, low dose group 0.69g crude drug/kg and vehicle group all do not cause Cavia porcellus to occur symptoms of allergic.
Irritation test
High dose group 12.4 crude drug g/kg of the present invention, low dose group 7.7 crude drug g/kg, to single, repeatedly back administration, do not produce any irritant reaction to animal intact skin, damaged skin, therefore the present invention repeatedly percutaneous drug delivery be safe.
Pharmacodynamics is tested:
Invention has been the tests such as the side of tearing open, analgesia, inflammatory swelling, capillary permeability, union of wounded skin, heat clearing away, infection.
The present invention obviously can increase scald, burn, skin cuts wound healing, and along with the prolongation of time, Wound healing rate increase even reaches the effect of recovery from illness; Obviously can reduce IL-1, IL-6, TNF-alpha content in rat blood serum; Granulation tissue fibroblasts and new capillary vessel quantity after increasing skin cuts 7d, reduce Granulation tissue fibroblasts and new capillary vessel quantity after 14d; Can significantly improve the mice threshold of pain, upon administration during 1.0-1.5h, peak in the threshold of pain simultaneously; The present invention all can obviously reduce mouse writhing number of times; The penetrating amount of large Corium Mus immersion dyestuff caused after all obviously reducing scald, reduces the permeability of blood capillary; The mice ear that can obviously suppress dimethylbenzene to cause; The rat paw edema caused by 1% carrageenin all obviously can be suppressed in each period of 1.5h, 3.5h, 5.5h, 7.5h; After rat pyrogenicity, after 60min, 120min, 180min, there is obvious refrigeration function; Antibacterial and bactericidal action preferably is all had to colon bacillus, staphylococcus aureus, pseudomonas aeruginosa, Candida albicans.
The present invention can suppress to scald Earlier period of inflammation medium IL-1, the release of IL-6, TNF-α; Symptom is scalded in rapid alleviation, has the effect that obvious wound healing is even fully recovered; To inflammation, the pain of scalding formation, all there is obvious antiinflammatory, antibacterial, antipyretic effect.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the invention will be further described.
Embodiment 1
A kind of nursing medicinal liquid being used for the treatment of burn and scald, it comprises Chinese medicine and western medicine composition, this nursing medicinal liquid is grouped into by following one-tenth by weight: the Radix Angelicae Dahuricae Oleum Sesami of 600g, the Concha Margaritifera of 70g, the Radix Arnebiae (Radix Lithospermi) of 70g, the Borneolum Syntheticum of 50g, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 80g, the Radix Sanguisorbae of 120g, the Radix Et Rhizoma Rhei of 220g, the Radix Angelicae Sinensis of 100g, the rock Radix Sophorae Flavescentis of 100g, the Typhonium divaricatum (L.) Decne of 130g, the Fructus Cnidii of 180g, the fructus kochiae of 70g, the Flos Lonicerae of 140g, the white osmanthus of 80g, the Herba Menthae of 60g, the Radix Ampelopsis of 70g, the Radix Notoginseng of 70g, the Margarita powder of 60g, the Mel of 4g, the chlorhexidine acetate of 1g, the miconazole nitrate of 2g, the amoxicillin of 4g, the cefalexin of 2g and the furazolidone powder of 2g.
In addition, a kind ofly prepare the described method being used for the treatment of the nursing medicinal liquid of burn and scald, the method comprises the following steps:
1) rinsing oven dry or the Concha Margaritifera dried, Radix Arnebiae (Radix Lithospermi), Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae and Radix Et Rhizoma Rhei is taken according to above-mentioned weight portion, mix homogeneously, drying 40 minutes at 55 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 60 mesh sieves; Then at 75 DEG C dry 20 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 60 minutes, then put it in ultrafine crusher the fine powder being ground into 200 mesh sieves, and mix homogeneously; Put into Radix Angelicae Dahuricae Oleum Sesami and stir immersion 3 days, for subsequent use;
2) Radix Angelicae Sinensis of above-mentioned weight portion, Radix Notoginseng, Typhonium divaricatum (L.) Decne and Fructus Cnidii mix homogeneously is taken, drying 20 minutes at 55 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 70 mesh sieves; Add Radix Angelicae Sinensis, Radix Notoginseng, Typhonium divaricatum (L.) Decne and the weight of Fructus Cnidii and the mass concentration of 2.5 times is that the ethanol of 75% is 50 DEG C of heating, reflux, extract, 3 times, each 2.5 hours, by obtained ethanol extract, being concentrated into liquor strength 55 DEG C of heating is 0.3g crude drug/ml, be dried to powder, obtain alcohol extraction xeraphium for subsequent use;
3) fructus kochiae of above-mentioned weight portion, Flos Lonicerae and Bai Gui are added the water of 6 times amount, heated and boiled 2 hours, extract; Add the water of 5 times amount again, heated and boiled 2 hours, extract; Merge extracted twice liquid, filter for subsequent use;
4) Herba Menthae of above-mentioned weight portion and Radix Ampelopsis are cleaned, chopping, mashes, adds the distilled water of 5 times amount, stir, and filters, taking juice, for subsequent use;
5) shredded by the rock Radix Sophorae Flavescentis of above-mentioned weight portion, with steaming with vinegar 2 hours, then add Borneolum Syntheticum, Margarita powder and the Mel of above-mentioned weight portion decocted 5 hours, use 500 mesh screen, extracted medicinal liquid for subsequent use;
6) chlorhexidine acetate of above-mentioned weight portion, miconazole nitrate, amoxicillin, cefalexin and furazolidone powder are added conventional debugger agent, pH value is transferred to prescribed limit, for subsequent use;
7) by step 6) reagent modulated joins step 1) in the product of gained, be uniformly mixed, extract medicinal liquid for subsequent use;
8) by step 2 ~ 5) and 7) the product mixing decoction of gained 2 times, 2.5 hours first times, second time 2.5 hours, use 600 mesh screen, extraction medicinal liquid, for subsequent use;
9) by 8) medicinal liquid of step gained adds PH and debugs agent, and pH value is adjusted to prescribed limit, and capping of bottling afterwards, to obtain final product.
Wherein said pH value is 5.3, described ultrafine crusher CF air flow super machine.
Embodiment 2
A kind of nursing medicinal liquid being used for the treatment of burn and scald, it comprises Chinese medicine and western medicine composition, this nursing medicinal liquid is grouped into by following one-tenth by weight: the Radix Angelicae Dahuricae Oleum Sesami of 500g, the Concha Margaritifera of 100g, the Radix Arnebiae (Radix Lithospermi) of 20g, the Borneolum Syntheticum of 90g, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 50g, the Radix Sanguisorbae of 150g, the Radix Et Rhizoma Rhei of 200g, the Radix Angelicae Sinensis of 150g, the rock Radix Sophorae Flavescentis of 80g, the Typhonium divaricatum (L.) Decne of 150g, the Fructus Cnidii of 150g, the fructus kochiae of 100g, the Flos Lonicerae of 120g, the white osmanthus of 100g, the Herba Menthae of 50g, the Radix Ampelopsis of 100g, the Radix Notoginseng of 50g, the Margarita powder of 80g, the Mel of 3g, the chlorhexidine acetate of 2g, the miconazole nitrate of 1g, the amoxicillin of 5g, the cefalexin of 1g and the furazolidone powder of 5g.
In addition, a kind ofly prepare the described method being used for the treatment of the nursing medicinal liquid of burn and scald, the method comprises the following steps:
1) rinsing oven dry or the Concha Margaritifera dried, Radix Arnebiae (Radix Lithospermi), Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae and Radix Et Rhizoma Rhei is taken according to above-mentioned weight portion, mix homogeneously, drying 30 minutes at 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 70 mesh sieves; Then at 65 DEG C dry 30 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 40 minutes, then put it in ultrafine crusher the fine powder being ground into 220 mesh sieves, and mix homogeneously; Put into Radix Angelicae Dahuricae Oleum Sesami and stir immersion 2 days, for subsequent use;
2) Radix Angelicae Sinensis of above-mentioned weight portion, Radix Notoginseng, Typhonium divaricatum (L.) Decne and Fructus Cnidii mix homogeneously is taken, drying 15 minutes at 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 80 mesh sieves; Add Radix Angelicae Sinensis, Radix Notoginseng, Typhonium divaricatum (L.) Decne and the weight of Fructus Cnidii and the mass concentration of 2.5 times is that the ethanol of 70% is 60 DEG C of heating, reflux, extract, 3 times, each 1.5 hours, by obtained ethanol extract, being concentrated into liquor strength 65 DEG C of heating is 0.3g crude drug/ml, be dried to powder, obtain alcohol extraction xeraphium for subsequent use;
3) fructus kochiae of above-mentioned weight portion, Flos Lonicerae and Bai Gui are added the water of 5 times amount, heated and boiled 3 hours, extract; Add the water of 5 times amount again, heated and boiled 1 hour, extract; Merge extracted twice liquid, filter for subsequent use;
4) Herba Menthae of above-mentioned weight portion and Radix Ampelopsis are cleaned, chopping, mashes, adds the distilled water of 6 times amount, stir, and filters, taking juice, for subsequent use;
5) shredded by the rock Radix Sophorae Flavescentis of above-mentioned weight portion, with steaming with vinegar 2 hours, then add Borneolum Syntheticum, Margarita powder and the Mel of above-mentioned weight portion decocted 2 hours, use 500 mesh screen, extracted medicinal liquid for subsequent use;
6) chlorhexidine acetate of above-mentioned weight portion, miconazole nitrate, amoxicillin, cefalexin and furazolidone powder are added conventional debugger agent, pH value is transferred to prescribed limit, for subsequent use;
7) by step 6) reagent modulated joins step 1) in the product of gained, be uniformly mixed, extract medicinal liquid for subsequent use;
8) by step 2 ~ 5) and 7) the product mixing decoction of gained 2 times, 3.5 hours first times, second time 1.5 hours, use 600 mesh screen, extraction medicinal liquid, for subsequent use;
9) by 8) medicinal liquid of step gained adds PH and debugs agent, and pH value is adjusted to prescribed limit, and capping of bottling afterwards, to obtain final product.
Wherein, described pH value is 5.8, described ultrafine crusher CF air flow super machine.
Embodiment 3
A kind of nursing medicinal liquid being used for the treatment of burn and scald, it comprises Chinese medicine and western medicine composition, this nursing medicinal liquid is grouped into by following one-tenth by weight: the Radix Angelicae Dahuricae Oleum Sesami of 800g, the Concha Margaritifera of 40g, the Radix Arnebiae (Radix Lithospermi) of 120g, the Borneolum Syntheticum of 20g, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 100g, the Radix Sanguisorbae of 100g, the Radix Et Rhizoma Rhei of 250g, the Radix Angelicae Sinensis of 50g, the rock Radix Sophorae Flavescentis of 120g, the Typhonium divaricatum (L.) Decne of 100g, the Fructus Cnidii of 200g, the fructus kochiae of 50g, the Flos Lonicerae of 150g, the white osmanthus of 50g, the Herba Menthae of 80g, the Radix Ampelopsis of 50g, the Radix Notoginseng of 80g, the Margarita powder of 50g, the Mel of 5g, the chlorhexidine acetate of 1g, the miconazole nitrate of 2g, the amoxicillin of 2g, the cefalexin of 2g and the furazolidone powder of 2g part.
In addition, a kind ofly prepare the described method being used for the treatment of the nursing medicinal liquid of burn and scald, the method comprises the following steps:
1) rinsing oven dry or the Concha Margaritifera dried, Radix Arnebiae (Radix Lithospermi), Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae and Radix Et Rhizoma Rhei is taken according to above-mentioned weight portion, mix homogeneously, drying 30 ~ 40 minutes at 55 ~ 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 60 ~ 70 mesh sieves; Then at 65 ~ 75 DEG C dry 20 ~ 30 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 40 ~ 60 minutes, then put it in ultrafine crusher the fine powder being ground into 200 ~ 220 mesh sieves, and mix homogeneously; Put into Radix Angelicae Dahuricae Oleum Sesami and stir immersion 2 ~ 3 days, for subsequent use;
2) Radix Angelicae Sinensis of above-mentioned weight portion, Radix Notoginseng, Typhonium divaricatum (L.) Decne and Fructus Cnidii mix homogeneously is taken, drying 15 ~ 20 minutes at 55 ~ 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 70 ~ 80 mesh sieves; Add Radix Angelicae Sinensis, Radix Notoginseng, Typhonium divaricatum (L.) Decne and the weight of Fructus Cnidii and the mass concentration of 2.5 times is that the ethanol of 70 ~ 75% is 50 ~ 60 DEG C of heating, reflux, extract, 3 times, each 1.5 ~ 2.5 hours, by obtained ethanol extract, being concentrated into liquor strength 55 ~ 65 DEG C of heating is 0.3g crude drug/ml, be dried to powder, obtain alcohol extraction xeraphium for subsequent use;
3) fructus kochiae of above-mentioned weight portion, Flos Lonicerae and Bai Gui are added the water of 5 ~ 6 times amount, heated and boiled 2 ~ 3 hours, extract; Add the water of 5 times amount again, heated and boiled 1 ~ 2 hour, extract; Merge extracted twice liquid, filter for subsequent use;
4) Herba Menthae of above-mentioned weight portion and Radix Ampelopsis are cleaned, chopping, mashes, adds the distilled water of 5 ~ 6 times amount, stir, and filters, taking juice, for subsequent use;
5) shredded by the rock Radix Sophorae Flavescentis of above-mentioned weight portion, with steaming with vinegar 2 hours, then add Borneolum Syntheticum, Margarita powder and the Mel of above-mentioned weight portion decocted 2 ~ 5 hours, and use 500 mesh screen, extraction medicinal liquid is for subsequent use;
6) chlorhexidine acetate of above-mentioned weight portion, miconazole nitrate, amoxicillin, cefalexin and furazolidone powder are added conventional debugger agent, pH value is transferred to prescribed limit, for subsequent use;
7) by step 6) reagent modulated joins step 1) in the product of gained, be uniformly mixed, extract medicinal liquid for subsequent use;
8) by step 2 ~ 5) and 7) the product mixing decoction of gained 2 times, 2.5 ~ 3.5 hours first times, second time 1.5 ~ 2.5 hours, use 600 mesh screen, extraction medicinal liquid, for subsequent use;
9) by 8) medicinal liquid of step gained adds PH and debugs agent, and pH value is adjusted to prescribed limit, and capping of bottling afterwards, to obtain final product.
Wherein, described pH value is 5.3 ~ 5.8, described ultrafine crusher CF air flow super machine.
Clinical practice
Case 1: Wu, man, 44 years old, liquefied gas was burnt, and treats one week, unsatisfactory curative effect.Rear painting nursing medicinal liquid rear face in January of the present invention is fully recovered, without any cicatrix.
Case 2: Yan, female, 50 years old, boiled water treats 5 days, poor effect after scalding in locality., body temperature 39.2 DEG C time medical, great quantity of water drinking, cheilosis, dewatering symptom is obvious, adopt Chinese medicine for oral administration fluid infusion immediately, the treatment of external application Shore burn externally applied formulation, after 5 days, dewatering symptom disappears, and treats recovery from illness in 27 days in my institute.A little cicatrix nonfunctional obstacle is had through paying a return visit.Be coated with nursing medicinal liquid of the present invention after 10 days, recovery from illness.Only leave slight cicatrix, nonfunctional obstacle.
Also do special clinical research with this Chinese medicine in addition.
Clinical trial
Object: patient populations 300 example, 35 ~ 60 years old age.Once burned patient number was 50, and two degree of burned patient numbers are 100, and three degree of burned patient numbers are 150.
Diagnostic criteria:
Effective: burn and scald symptom has clear improvement.
Successful: cicatrix is eliminated completely, face is as usual, no longer continues medication.
Effect is general: have certain for scar effect, but still need continue medication.
Effective, but not obvious: except scar effect is poor, still need to continue medication.
To no effect: cicatrix, without improvement, need be treated with other drug.
Method: the nursing medicinal liquid in present embodiment is respectively once coated with use, follow-up observation in 2 months every day sooner or later.
Result: the cure rate for the treatment of is 80%; Total effective rate is 95.5%.Condition-inference all accepts and believe the diagnosis that regular hospital provides.
For strengthening the effect of this Chinese medicine, also can add the Lignum Sappan that weight portion is 15 ~ 20 parts again in mentioned component, the Folium Artemisiae Argyi of the Myrrha of 10 ~ 15 parts and 5 ~ 8 parts.By Lignum Sappan, Myrrha and Folium Artemisiae Argyi at 60 ~ 65 DEG C dry 30 ~ 40 minutes, dry limit, limit uniform stirring, be ground into fines with pulverizer afterwards and cross 280 mesh sieves, then be directly mixed into above-mentioned steps 5 by crossing the fines of 280 mesh sieves) rock Radix Sophorae Flavescentis in, with steaming with vinegar 2 hours, then add Borneolum Syntheticum, Margarita powder and the Mel of above-mentioned weight portion decoct 2 hours, use 500 mesh screen, extract medicinal liquid for subsequent use; Other step is the same.
Of the present invention be used for the treatment of burn and scald nursing medicinal liquid painting convenience, short treating period, instant effect, have no side effect and can not drug dependence be formed.This nursing medicinal liquid Chinese and Western combines, and pain relieving is rapid-action, and healing ability is strong, shortens 1/3rd than the general course for the treatment of; Antiphlogistic antibacterial is good, has inhibitory action to general drug tolerant bacteria, has very strong bacteriostasis especially to bacillus pyocyaneus common in burn and scald, staphylococcus aureus, escherichia coli, Candida albicans.The material composition resource abundance being used for the treatment of the nursing medicinal liquid of burn and scald is guaranteed, and efficiency is high, and economic benefit, social benefit are remarkable.Finally, the preparation method being used for the treatment of the nursing medicinal liquid of burn and scald of the present invention is simple, and cost is low, is convenient to promote.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. one kind is used for the treatment of the nursing medicinal liquid of burn and scald, it comprises Chinese medicine and western medicine composition, it is characterized in that this nursing medicinal liquid is grouped into by following one-tenth by weight: the Radix Angelicae Dahuricae Oleum Sesami of 50 ~ 80 parts, the Concha Margaritifera of 4 ~ 10 parts, the Radix Arnebiae (Radix Lithospermi) of 2 ~ 12 parts, the Borneolum Syntheticum of 2 ~ 9 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 5 ~ 10 parts, the Radix Sanguisorbae of 10 ~ 15 parts, the Radix Et Rhizoma Rhei of 20 ~ 25 parts, the Radix Angelicae Sinensis of 5 ~ 15 parts, the rock Radix Sophorae Flavescentis of 8 ~ 12 parts, the Typhonium divaricatum (L.) Decne of 10 ~ 15 parts, the Fructus Cnidii of 15 ~ 20 parts, the fructus kochiae of 5 ~ 10 parts, the Flos Lonicerae of 12 ~ 15 parts, the white osmanthus of 5 ~ 10 parts, the Herba Menthae of 5 ~ 8 parts, the Radix Ampelopsis of 5 ~ 10 parts, the Radix Notoginseng of 5 ~ 8 parts, the Margarita powder of 5 ~ 8 parts, the Mel of 0.3 ~ 0.5 part, the chlorhexidine acetate of 0.1 ~ 0.2 part, the miconazole nitrate of 0.1 ~ 0.2 part, the amoxicillin of 0.2 ~ 0.5 part, the furazolidone powder of the cefalexin of 0.1 ~ 0.2 part and 0.2 ~ 0.5 part.
2. the nursing medicinal liquid being used for the treatment of burn and scald according to claim 1, it is characterized in that this nursing medicinal liquid is grouped into by following one-tenth by weight: the Radix Angelicae Dahuricae Oleum Sesami of 60 parts, the Concha Margaritifera of 7 parts, the Radix Arnebiae (Radix Lithospermi) of 7 parts, the Borneolum Syntheticum of 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 8 parts, the Radix Sanguisorbae of 12 parts, the Radix Et Rhizoma Rhei of 22 parts, the Radix Angelicae Sinensis of 10 parts, the rock Radix Sophorae Flavescentis of 10 parts, the Typhonium divaricatum (L.) Decne of 13 parts, the Fructus Cnidii of 18 parts, the fructus kochiae of 7 parts, the Flos Lonicerae of 14 parts, the white osmanthus of 8 parts, the Herba Menthae of 6 parts, the Radix Ampelopsis of 7 parts, the Radix Notoginseng of 7 parts, the Margarita powder of 6 parts, the Mel of 0.4 part, the chlorhexidine acetate of 0.1 part, the miconazole nitrate of 0.2 part, the amoxicillin of 0.4 part, the furazolidone powder of the cefalexin of 0.2 part and 0.2 part.
3. prepare the method being used for the treatment of the nursing medicinal liquid of burn and scald according to claim 1 and 2, it is characterized in that the method comprises the following steps:
1) rinsing oven dry or the Concha Margaritifera dried, Radix Arnebiae (Radix Lithospermi), Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae and Radix Et Rhizoma Rhei is taken according to above-mentioned weight portion, mix homogeneously, drying 30 ~ 40 minutes at 55 ~ 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 60 ~ 70 mesh sieves; Then at 65 ~ 75 DEG C dry 20 ~ 30 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 40 ~ 60 minutes, then put it in ultrafine crusher the fine powder being ground into 200 ~ 220 mesh sieves, and mix homogeneously; Put into Radix Angelicae Dahuricae Oleum Sesami and stir immersion 2 ~ 3 days, for subsequent use;
2) Radix Angelicae Sinensis of above-mentioned weight portion, Radix Notoginseng, Typhonium divaricatum (L.) Decne and Fructus Cnidii mix homogeneously is taken, drying 15 ~ 20 minutes at 55 ~ 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 70 ~ 80 mesh sieves; Add Radix Angelicae Sinensis, Radix Notoginseng, Typhonium divaricatum (L.) Decne and the weight of Fructus Cnidii and the mass concentration of 2.5 times is that the ethanol of 70 ~ 75% is 50 ~ 60 DEG C of heating, reflux, extract, 3 times, each 1.5 ~ 2.5 hours, by obtained ethanol extract, being concentrated into liquor strength 55 ~ 65 DEG C of heating is 0.3g crude drug/ml, be dried to powder, obtain alcohol extraction xeraphium for subsequent use;
3) fructus kochiae of above-mentioned weight portion, Flos Lonicerae and Bai Gui are added the water of 5 ~ 6 times amount, heated and boiled 2 ~ 3 hours, extract; Add the water of 5 times amount again, heated and boiled 1 ~ 2 hour, extract; Merge extracted twice liquid, filter for subsequent use;
4) Herba Menthae of above-mentioned weight portion and Radix Ampelopsis are cleaned, chopping, mashes, adds the distilled water of 5 ~ 6 times amount, stir, and filters, taking juice, for subsequent use;
5) shredded by the rock Radix Sophorae Flavescentis of above-mentioned weight portion, with steaming with vinegar 2 hours, then add Borneolum Syntheticum, Margarita powder and the Mel of above-mentioned weight portion decocted 2 ~ 5 hours, and use 500 mesh screen, extraction medicinal liquid is for subsequent use;
6) chlorhexidine acetate of above-mentioned weight portion, miconazole nitrate, amoxicillin, cefalexin and furazolidone powder are added conventional debugger agent, pH value is transferred to prescribed limit, for subsequent use;
7) by step 6) reagent modulated joins step 1) in the product of gained, be uniformly mixed, extract medicinal liquid for subsequent use;
8) by step 2 ~ 5) and 7) the product mixing decoction of gained 2 times, 2.5 ~ 3.5 hours first times, second time 1.5 ~ 2.5 hours, use 600 mesh screen, extraction medicinal liquid, for subsequent use;
9) by 8) medicinal liquid of step gained adds PH and debugs agent, and pH value is adjusted to prescribed limit, and capping of bottling afterwards, to obtain final product.
4. the method for the nursing medicinal liquid for the preparation for the treatment of burn and scald according to claim 3, is characterized in that 1 part of described raw material weight for 10g.
5. the method for the nursing medicinal liquid for the preparation for the treatment of burn and scald according to claim 3 or 4, is characterized in that described pH value is 5.3 ~ 5.8.
6. the method for the nursing medicinal liquid for the preparation for the treatment of burn and scald according to claim 5, is characterized in that described ultrafine crusher CF air flow super machine.
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| CN114129622A (en) * | 2021-11-19 | 2022-03-04 | 四川视佳生物科技有限公司 | Composition for treating burns and scalds, preparation method and application thereof |
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