CN104758835A - Traditional Chinese medicine for treating cerebral infarction disease - Google Patents
Traditional Chinese medicine for treating cerebral infarction disease Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating cerebral infarction disease. The traditional Chinese medicine is characterized by being prepared from the following raw materials in parts by weight: 25-30 parts ofherb of bodinier elsholtzia, 10-15 parts of beartiful sweetgum fruit, 20-25 parts of herb of sessilefruit chinaure, 20-25 parts of gynostemma pentaphyllum makino, 8-12 parts of root of doubleteeth pubescent angelica, 25-35 parts of danshen, 15-20 parts of grass leaf sweelflag rhizome, 5-10 parts of all-grass of common renanthera, 5-10 parts of raw rhubarb, 12-15 parts of vinegar-processed zedoary rhizome, 5-10 parts of red peony root, 5-8 parts of leeches, 20-30 parts of virgate wormwood herb and 5-8 parts of additive, wherein the additive is the mixture of xylitol, dextrin, calcium hydrogen phosphate and citric acid. The traditional Chinese medicine is convenient to take, short in course of treatment, quick in effect taking, free from toxic and side effects and capable of avoiding pharmacological dependency.
Description
Technical field
The invention belongs to Chinese medicine field, be specifically related to a kind of Chinese medicine for the treatment of cerebral infarction disease.
Background technology
Cerebral Vascular Disease rate is high, mortality rate is high, disability rate is high, and the cerebrovascular of China has occupied the first place of the cause of death, and wherein 80% is acute thrombotic cerebral infarction.Clinical common type has acute complete cerebral infarction, treatment of progressive cerebral infarction, lacunar infarction.Nearly all cerebral infarction is all that thrombosis causes vascular occlusion on diabetes, coronary heart disease, dysbolism of blood fat, blood constituent exception and arteriosclerosis basis.The traditional Chinese medical science thinks that cerebral infarction is Primary Asthenia-Secondary Sthenia Syndrome, and deficiency in origin is the deficiency of vital energy, the deficiency of YIN is this, and primary disease is mainly in middle-aged and elderly people, and it is main for mostly being the deficiency of vital energy, the spleen being the foundation of acquired constitution, the spleen governs the blood, main transmitting and distributing the fluids; Temper virtual loss, dysfunction of the spleen in transportation, then accumulatively wet raise phlegm, gas carries blood, and the deficiency of vital energy is blood stasis then, and the stagnant venation of expectorant stasis blocking occurs hemiplegia.Expectorant turbid congestion retardance brain network, hematogenous blockage, menstruation disorder is then water, and the water stasis of blood is tied mutually, win in brain key be the basic pathogenesis of acute period of cerebral infarction.
At present, the Therapeutic Method of cerebral infarction roughly has following several: 1, operative treatment, the curative effect of operative treatment cerebral infarction, mortality rate and disability rate all do not form unified conclusion, even if partial surgical case can improve the recent survival rate of patient, but long-term effect is often not as good as in the recent period, not satisfactory, and Cerebral Infarction Patients is mainly in the old people of six or seven ten years old, Abwehrkraft des Koepers and toleration are all more weak, therefore, except several special brain jam type or be save except patient vitals in time, how not advise adopting operative treatment; 2, western medicine, western medicine cerebral infarction has advantage rapid-action, with strong points, but western medicine target spot is single, be difficult to accomplish genuine large compound recipe modern Chinese medicine of drawing materials, namely the object simultaneously can treated from blood and blood vessel, and cerebral infarction dysemia (disease such as blood viscosity, hyperlipidemia) and vascular lesion (atheromatous plaque formation, luminal stenosis etc.) coefficient result just, and most Western medicine, comprises aspirin and all can produce different drug resistance; Aspirin has certain medication opposing, and the side effect of most Western medicine all clearly.These all have certain limitation to the use of patient.
Summary of the invention
For solving the problem, the invention provides a kind of Chinese medicine for the treatment of cerebral infarction disease, it have benefiting QI for activating blood circulation, the effect of pain relieving of having one's ideas straightened out, more fully can treat multiple cerebral infarction and prevent it from recurring, be treatment and prevention cerebral infarction active drug.
The present invention is a kind of Chinese medicine for the treatment of cerebral infarction disease for solving the problems of the technologies described above adopted technical scheme, this Chinese medicine is made up of following raw material by weight: the toothbrush grass of 25 ~ 30 parts, the Fructus Liquidambaris of 10 ~ 15 parts, the stone Fructus Piperis of 20 ~ 25 parts, the gynostemma pentaphyllum makino of 20 ~ 25 parts, 8 ~ 12 parts solely shake grass, the Radix Salviae Miltiorrhizae of 25 ~ 35 parts, the water Rhizoma Acori Graminei of 15 ~ 20 parts, the Herba Renantherae coccineae of 5 ~ 10 parts, the Radix Et Rhizoma Rhei of 5 ~ 10 parts, the stir-baked RHIIZOMA CURCUMAE with vinegar of 12 ~ 15 parts, the Radix Paeoniae Rubra of 5 ~ 10 parts, the Hirudo of 5 ~ 8 parts, the Herba Artemisiae Scopariae of 20 ~ 30 parts and 5 ~ 8 parts of additives, this additive is xylitol, dextrin, the mixture of calcium hydrogen phosphate and citric acid,
This Chinese medicine is prepared through the following steps:
1) according to toothbrush grass, Fructus Liquidambaris, stir-baked RHIIZOMA CURCUMAE with vinegar and gynostemma pentaphyllum makino that above-mentioned weight portion takes rinsing oven dry or dries, mix homogeneously, drying 30 ~ 40 minutes at 55 ~ 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 60 ~ 70 mesh sieves; Then at 65 ~ 75 DEG C dry 20 ~ 30 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 40 ~ 60 minutes, then put it in ultrafine crusher the fine powder being ground into 200 ~ 220 mesh sieves, and mix homogeneously;
2) what take above-mentioned weight portion solely shakes grass, Radix Salviae Miltiorrhizae, water Rhizoma Acori Graminei and Herba Renantherae coccineae mix homogeneously, drying 15 ~ 20 minutes at 55 ~ 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 70 ~ 80 mesh sieves; Add and solely shake the weight of grass, Radix Salviae Miltiorrhizae, water Rhizoma Acori Graminei and Herba Renantherae coccineae and the mass concentration of 2.5 times is that the ethanol of 70 ~ 75% is 50 ~ 60 DEG C of heating, reflux, extract, 3 times, each 1.5 ~ 2.5 hours, by obtained ethanol extract, being concentrated into liquor strength 55 ~ 65 DEG C of heating is 0.3g crude drug/ml, be dried to powder, obtain alcohol extraction xeraphium for subsequent use;
3) Radix Paeoniae Rubra, Hirudo and Herba Artemisiae Scopariae are added the water of 5 ~ 6 times amount, heated and boiled 2 ~ 3 hours, extract; Add the water of 5 times amount again, heated and boiled 1 ~ 2 hour, extract; Merge extracted twice liquid, filter, filtrate is condensed into the thick paste of relative density 1.13 ~ 1.15 at 60 DEG C, for subsequent use;
4) Radix Et Rhizoma Rhei and stone Fructus Piperis are cleaned, chopping, mashes, adds the distilled water of 5 ~ 6 times amount, stir, and filters, taking juice, for subsequent use;
5) by step 1) ~ 4) products therefrom and described additive fully mix, be pressed into tablet, obtain final product.
Preferably, this Chinese medicine is made up of following raw material by weight: the toothbrush of 28 parts grass, 12 parts Fructus Liquidambaris, 23 parts stone Fructus Piperis, 22 parts gynostemma pentaphyllum makino, 10 parts solely shake grass, the Radix Salviae Miltiorrhizae of 30 parts, the water Rhizoma Acori Graminei of 17 parts, the Herba Renantherae coccineae of 8 parts, the Radix Et Rhizoma Rhei of 7 parts, the stir-baked RHIIZOMA CURCUMAE with vinegar of 13 parts, the Radix Paeoniae Rubra of 7 parts, the Hirudo of 6 parts, the Herba Artemisiae Scopariae of 25 parts and 7 parts of additives.
In above-mentioned either a program preferably, 1 part of described raw material weight is 10g.
In above-mentioned either a program preferably, in described additive, the weight ratio of xylitol, dextrin, calcium hydrogen phosphate and citric acid is 1:0.5:1:0.5.
In above-mentioned either a program preferably, described ultrafine crusher CF air flow super machine.
Wherein,
Solely shake grass: bitter, sweet, flat, nontoxic, cure mainly: apoplexy, ventilate feel cold, be unreasonable, paralyse, the cramp of postpartum apoplexy, extremity, agraphia, puerperal abdonimal pain, arthralgia, wind tooth swell and ache, inflammation of the throat lockjaw, TAI YANG headache.
Radix Et Rhizoma Rhei: major function is stasis removing, relieving constipation by purgation, stagnates for Gastrointestinal excess heat, constipation.
Water Rhizoma Acori Graminei: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.
Fructus Liquidambaris: dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension.
Stir-baked RHIIZOMA CURCUMAE with vinegar: possess the effect that selectivity increases brain current amount, to impaired cerebral tissue reparation by benifit.
Radix Salviae Miltiorrhizae: GUIXIN, Liver Channel, can stasis-dispelling and pain-killing, promoting blood flow to regulate menstruation, lowering blood-fat and reducing weight, clear away heart-fire relieving restlessness.Effective treatment heart, brain, angiopathy, obesity and hyperlipemia.
Toothbrush grass: there is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, the function such as anticancer.Sour in the mouth cold in nature, containing compositions such as multivitamin, trace element and aminoacid, has removing pathogenic heat from blood and toxic substance from the body, eliminating stasis to stop pain, effect of detumescence and clearing away heat-damp and promoting diuresis.
Stone Fructus Piperis: heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.For flu, tonsillitis, parotitis, bronchitis, stomachache abdominal distention, thromboangiitis obliterans, lumbago, traumatic injury.
Herba Renantherae coccineae: expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, cures mainly rheumatic arthralgia, fracture.
Radix Paeoniae Rubra: for thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, addiction abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.
Gynostemma pentaphyllum makino: replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing.
Hirudo: cure mainly lump in the abdomen stomachache, the disease such as blood-retention, traumatic blood stasis are had a pain, carbuncle erysipelas.
Herba Artemisiae Scopariae: have function of gallbladder promoting, the function of protection liver, antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating.
The mixture of xylitol, dextrin, calcium hydrogen phosphate and citric acid: additive and sweeting agent, homergy in reinforcement.
Beneficial effect of the present invention:
1. this treatment cerebral infarction disease Chinese medicine taking convenience, short treating period, instant effect, have no side effect and can not drug dependence be formed.
2. Chinese medicine of the present invention is pure Chinese medicinal preparation, there is benefiting QI for activating blood circulation, to have one's ideas straightened out effect of pain relieving, for the apoplexy caused by blood stasis due to qi deficiency, the thoracic obstruction, have a dizzy spell, the symptom such as hemiplegia, pained, shortness of breath and palpitation uncomfortable in chest, can more fully treat the symptoms such as multiple cerebral infarction, hemiplegia, aphasia and prevent it from recurring.
3. the raw material resources abundance of this Chinese medicine is guaranteed, and efficiency is high, and economic benefit, social benefit are remarkable.
Above-mentioned raw material of Chinese medicine is through to be verified for many years, records and test gained, although their effect is different, but choosing of each Chinese medicine is not random and be, the application is according to the proportioning of each composition of test gained for many years, be not by raw material effect simple superposition of each composition, because the multiple interactivelies such as interpromoting relation in five elements, mutual reinforcement between, mutual restraint between two drugs or the mutual-detoxication may be there is between various raw material of Chinese medicine, and the application have selected above-mentioned raw materials accordingly according to this principle exactly, and the optimum proportioning determined between them, therefore, the application has significant meaning.
Chinese medicine of the present invention shows through safety toxicology test: LD50 is 8800mg/kg, and Toxicological evaluation is actual nontoxic level, has no side effect.
Acute toxicity test
Above-mentioned laboratory sample is made suspension, to be equivalent to the dosage of clinical daily dosage 420 times to mouse stomach administration, at viewing duration, does not find that animal has any toxic reaction.Administration is observed for 15 days, none animal dead; Dissect after sacrifice of animal, its internal organs observe Non Apparent Abnormality.Experiment shows, gastric infusion does not measure median lethal dose(LD 50) of the present invention, and zooperal dosis tolerata is clinical adult's every day 300 times of maximum dose.
Long-term toxicity test for animals
By above-mentioned sample with clinical daily dosage 5 times, the long term administration in 6 months of 15 times, 70 times confession rats, the general activity after the large raticide of two dosage groups, the mental status, hair, feces etc. are showed no obvious abnormalities; Peripheral hemogram before and after administration, comprises erythrocyte, platelet, hemoglobin, packed cell volume all fluctuates within normal range; Obvious impact is showed no on Liver and kidney function index; The content of total protein, albumin, alkali phosphatase no significant difference compared with matched group in animal serum during off-test; Electrocardioscopy is all no abnormal; Each main organs macroscopy has no the morphological changes of various tissue components such as obvious enlargement, hyperemia, necrosis; The weight coefficient of the organs such as the heart, liver, spleen, lung, kidney, thymus, adrenal gland compared with matched group without significant difference; Histopathologic examination is showed no exception.These results suggest that the present invention is safer, without obvious toxic-side effects in tested dosage range,
Pharmacodynamics is tested:
Get 20-25g mice 30, be divided into 2 groups at random, often organize 15.Be respectively normal saline negative control group, Chinese medicine extract group of the present invention (5.0g/kg).Being made into volume is 25ml, by Mouse Weight 0.3ml/10g gavage, normal group to equal-volume normal saline, 1 day gavage once, continuous 2d, after the 3rd day last 1 administration 20min, tail vein injection derivant (collagen xxii protein 0 μ g/ only; Epinephrine 8 μ g/ is only) 0.1mL/10g, formed to bring out animal acute brain thromboembolism.Observe after every treated animal gives derivant and occur recovering normal number of animals after hemiplegia in hemiplegia, death and 20min in 20min, calculate protective rate (protective rate=recovery number/15).The results are shown in following table.
Table 1 the present invention causes the impact of mouse brain thromboembolism to derivant
| Group | Hemiplegia | Dead | Recover | Protective rate/% |
| Normal saline group | 10 | 5 | 0 | 0 |
| Of the present invention group | 5 | 0 | 10 | 70* |
Compare with normal saline group: * P<0.05.
Carry out statistical with simplification exact propability, compared with normal saline group, the ability of mice antagonism cerebral embolism can be significantly improved in Chinese medicine extract of the present invention, compare with normal saline group that there were significant differences (P<0.05).
Detailed description of the invention
Below in conjunction with detailed description of the invention, the invention will be further described.
Embodiment 1
A kind of Chinese medicine for the treatment of cerebral infarction disease, this Chinese medicine is made up of following raw material by weight: 250g toothbrush grass, 150g Fructus Liquidambaris, 200g stone Fructus Piperis, 250g gynostemma pentaphyllum makino, 80g solely shake grass, 350g Radix Salviae Miltiorrhizae, 150g water Rhizoma Acori Graminei, 100g Herba Renantherae coccineae, 50g Radix Et Rhizoma Rhei, 150g stir-baked RHIIZOMA CURCUMAE with vinegar, 50g Radix Paeoniae Rubra, 80g Hirudo, 200g Herba Artemisiae Scopariae and 80g additive, this additive is the mixture of xylitol, dextrin, calcium hydrogen phosphate and citric acid, and its weight ratio is 1:0.5:1:0.5;
This Chinese medicine is prepared through the following steps:
1) according to toothbrush grass, Fructus Liquidambaris, stir-baked RHIIZOMA CURCUMAE with vinegar and gynostemma pentaphyllum makino that above-mentioned weight portion takes rinsing oven dry or dries, mix homogeneously, drying 40 minutes at 55 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 60 mesh sieves; Then at 75 DEG C dry 20 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 60 minutes, then put it in ultrafine crusher the fine powder being ground into 200 mesh sieves, and mix homogeneously;
2) what take above-mentioned weight portion solely shakes grass, Radix Salviae Miltiorrhizae, water Rhizoma Acori Graminei and Herba Renantherae coccineae mix homogeneously, drying 15 minutes at 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 80 mesh sieves; Add and solely shake the weight of grass, Radix Salviae Miltiorrhizae, water Rhizoma Acori Graminei and Herba Renantherae coccineae and the mass concentration of 2.5 times is that the ethanol of 70% is 60 DEG C of heating, reflux, extract, 3 times, each 1.5 hours, by obtained ethanol extract, being concentrated into liquor strength 65 DEG C of heating is 0.3g crude drug/ml, be dried to powder, obtain alcohol extraction xeraphium for subsequent use;
3) Radix Paeoniae Rubra, Hirudo and Herba Artemisiae Scopariae are added the water of 5 times amount, heated and boiled 3 hours, extract; Add the water of 5 times amount again, heated and boiled 1 hour, extract; Merge extracted twice liquid, filter, filtrate is condensed into the thick paste of relative density 1.15 at 60 DEG C, for subsequent use;
4) Radix Et Rhizoma Rhei and stone Fructus Piperis are cleaned, chopping, mashes, adds the distilled water of 5 times amount, stir, and filters, taking juice, for subsequent use;
5) by step 1) ~ 4) products therefrom and described additive fully mix, be pressed into tablet, obtain final product.
Embodiment 2
A kind of Chinese medicine for the treatment of cerebral infarction disease, this Chinese medicine is made up of following raw material by weight: 280g toothbrush grass, 120g Fructus Liquidambaris, 230g stone Fructus Piperis, 220g gynostemma pentaphyllum makino, 100g solely shake grass, 300g Radix Salviae Miltiorrhizae, 170g water Rhizoma Acori Graminei, 80g Herba Renantherae coccineae, 70g Radix Et Rhizoma Rhei, 130g stir-baked RHIIZOMA CURCUMAE with vinegar, 70g Radix Paeoniae Rubra, 60g Hirudo, 250g Herba Artemisiae Scopariae and 70g additive, this additive is the mixture of xylitol, dextrin, calcium hydrogen phosphate and citric acid, and its weight ratio is 1:0.5:1:0.5;
This Chinese medicine is prepared through the following steps:
1) according to toothbrush grass, Fructus Liquidambaris, stir-baked RHIIZOMA CURCUMAE with vinegar and gynostemma pentaphyllum makino that above-mentioned weight portion takes rinsing oven dry or dries, mix homogeneously, drying 35 minutes at 60 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 65 mesh sieves; Then at 70 DEG C dry 25 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 50 minutes, then put it into the fine powder being ground into 210 mesh sieves in CF air flow super machine, and mix homogeneously;
2) what take above-mentioned weight portion solely shakes grass, Radix Salviae Miltiorrhizae, water Rhizoma Acori Graminei and Herba Renantherae coccineae mix homogeneously, drying 18 minutes at 60 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 75 mesh sieves; Add and solely shake the weight of grass, Radix Salviae Miltiorrhizae, water Rhizoma Acori Graminei and Herba Renantherae coccineae and the mass concentration of 2.5 times is that the ethanol of 72% is 55 DEG C of heating, reflux, extract, 3 times, each 1.8 hours, by obtained ethanol extract, being concentrated into liquor strength 60 DEG C of heating is 0.3g crude drug/ml, be dried to powder, obtain alcohol extraction xeraphium for subsequent use;
3) Radix Paeoniae Rubra, Hirudo and Herba Artemisiae Scopariae are added the water of 5.5 times amount, heated and boiled 2.5 hours, extract; Add the water of 5 times amount again, heated and boiled 1.5 hours, extract; Merge extracted twice liquid, filter, filtrate is condensed into the thick paste of relative density 1.14 at 60 DEG C, for subsequent use;
4) Radix Et Rhizoma Rhei and stone Fructus Piperis are cleaned, chopping, mashes, adds the distilled water of 5.5 times amount, stir, and filters, taking juice, for subsequent use;
5) by step 1) ~ 4) products therefrom and described additive fully mix, be pressed into tablet, obtain final product.
Embodiment 3
A kind of Chinese medicine for the treatment of cerebral infarction disease, this Chinese medicine is made up of following raw material by weight: 300g toothbrush grass, 100g Fructus Liquidambaris, 250g stone Fructus Piperis, 200g gynostemma pentaphyllum makino, 120g solely shake grass, 250g Radix Salviae Miltiorrhizae, 200g water Rhizoma Acori Graminei, 50g Herba Renantherae coccineae, 100g Radix Et Rhizoma Rhei, 120g stir-baked RHIIZOMA CURCUMAE with vinegar, 100g Radix Paeoniae Rubra, 50g Hirudo, 300g Herba Artemisiae Scopariae and 50g additive, this additive is the mixture of xylitol, dextrin, calcium hydrogen phosphate and citric acid, and its weight ratio is 1:0.5:1:0.5;
This Chinese medicine is prepared through the following steps:
1) according to toothbrush grass, Fructus Liquidambaris, stir-baked RHIIZOMA CURCUMAE with vinegar and gynostemma pentaphyllum makino that above-mentioned weight portion takes rinsing oven dry or dries, mix homogeneously, drying 30 minutes at 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 70 mesh sieves; Then at 65 DEG C dry 30 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 40 minutes, then put it in ultrafine crusher the fine powder being ground into 220 mesh sieves, and mix homogeneously;
2) what take above-mentioned weight portion solely shakes grass, Radix Salviae Miltiorrhizae, water Rhizoma Acori Graminei and Herba Renantherae coccineae mix homogeneously, drying 20 minutes at 55 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 70 mesh sieves; Add and solely shake the weight of grass, Radix Salviae Miltiorrhizae, water Rhizoma Acori Graminei and Herba Renantherae coccineae and the mass concentration of 2.5 times is that the ethanol of 75% is 50 DEG C of heating, reflux, extract, 3 times, each 2.5 hours, by obtained ethanol extract, being concentrated into liquor strength 55 DEG C of heating is 0.3g crude drug/ml, be dried to powder, obtain alcohol extraction xeraphium for subsequent use;
3) Radix Paeoniae Rubra, Hirudo and Herba Artemisiae Scopariae are added the water of 6 times amount, heated and boiled 2 hours, extract; Add the water of 5 times amount again, heated and boiled 2 hours, extract; Merge extracted twice liquid, filter, filtrate is condensed into the thick paste of relative density 1.13 at 60 DEG C, for subsequent use;
4) Radix Et Rhizoma Rhei and stone Fructus Piperis are cleaned, chopping, mashes, adds the distilled water of 6 times amount, stir, and filters, taking juice, for subsequent use;
5) by step 1) ~ 4) products therefrom and described additive fully mix, be pressed into tablet, obtain final product.
Clinical practice
Case 1: Wu, man, 64 years old, because of inarticulateness, slobbering, right hemiplegia, dull expression, the symptoms such as bradykinesia blood pressure 90-190 millimetres of mercury, be diagnosed as cerebral infarction, thing of taking medicine was not felt any better, and can only maintain.After take Chinese medicine of the present invention January after cancel and support medicine.The bad sensation after February that continues to take medicine disappears completely, and various inspection is all normal.
Case 2: Yan, female, 71 years old, symptom: walking is unstable, hypomnesis, right hand numb pain, gatism, aphasia etc., CT, MAR checked the blocking of diagnosis middle cerebral artery, and left brain large area infraction, the cone end, basal ganglia region all have problems.Take Chinese medicine composition of the present invention after 10 days, consciousness starts to regain consciousness, and continue six courses for the treatment of of taking medicine, symptom disappears substantially, and additional exercise, health is progressively got well.
Also do special clinical research with this Chinese medicine in addition.
Object: Cerebral Infarction Patients 300 example, 50 ~ 75 years old age, wherein male 185 example, women 115 example.
Diagnostic criteria: all make a definite diagnosis with CT, meets doctor trained in Western medicine " cerebral infarction " diagnostic criteria, meets apoplexy in Chinese medicine standard, and the onset time, within 7 days, merges serious cardiopulmonary Liver and kidney or various hematopathy, psychosis etc.
Method: by the two panels of the medicine in present embodiment, takes sooner or later respectively once to the patient of cerebral infarction sequela, follow-up observation in 6 months every day.Wherein life can take care of oneself, can independent ambulation for cure; Myodynamia recovery is effective to 4 grades; All the other are invalid.
Result: the cure rate for the treatment of is 48%, cures case 144 example; Total effective rate is 92.5%, cures case 277 example.This Chinese medicine is Be very effective in neurological functional recovery, quality of life raising etc.Condition-inference all accepts and believe the diagnosis that regular hospital provides.
For strengthening the effect of this Chinese medicine, also can add the Rhizoma Pinelliae Preparatum that weight portion is 15 ~ 20 parts again in above-mentioned raw materials, the Radix Rhodiolae of the Lacca of 10 ~ 15 parts and 5 ~ 8 parts; Also can add the second additive that weight portion is 2 ~ 3 parts, described second additive is made up of crystallization of mannitol, BETA-CD and stevioside, and each ingredient weight ratio is 0.5: 1: 1.By Rhizoma Pinelliae Preparatum, Lacca and Radix Rhodiolae at 60 ~ 65 DEG C dry 30 ~ 40 minutes, dry limit, limit uniform stirring, be ground into fines with pulverizer afterwards and cross 280 mesh sieves, then the direct fines by mistake 280 mesh sieves is mixed into above-mentioned steps 5) in, admix additive and second additive of above-mentioned weight portion again, then stir evenly, be pressed into tablet.
Chinese medicine taking convenience, short treating period, the instant effect of this treatment cerebral infarction disease, have no side effect and can not drug dependence be formed.For pure Chinese medicinal preparation, there is benefiting QI for activating blood circulation, to have one's ideas straightened out effect of pain relieving, for the apoplexy caused by blood stasis due to qi deficiency, the thoracic obstruction, have a dizzy spell, the symptom such as hemiplegia, pained, shortness of breath and palpitation uncomfortable in chest, can more fully treat the symptoms such as multiple cerebral infarction, hemiplegia, aphasia and prevent it from recurring.The raw material resources abundance of this Chinese medicine is guaranteed, and efficiency is high, and economic benefit, social benefit are remarkable.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (5)
1. treat the Chinese medicine of cerebral infarction disease for one kind, it is characterized in that this Chinese medicine is made up of following raw material by weight: the toothbrush grass of 25 ~ 30 parts, the Fructus Liquidambaris of 10 ~ 15 parts, the stone Fructus Piperis of 20 ~ 25 parts, the gynostemma pentaphyllum makino of 20 ~ 25 parts, 8 ~ 12 parts solely shake grass, the Radix Salviae Miltiorrhizae of 25 ~ 35 parts, the water Rhizoma Acori Graminei of 15 ~ 20 parts, the Herba Renantherae coccineae of 5 ~ 10 parts, the Radix Et Rhizoma Rhei of 5 ~ 10 parts, the stir-baked RHIIZOMA CURCUMAE with vinegar of 12 ~ 15 parts, the Radix Paeoniae Rubra of 5 ~ 10 parts, the Hirudo of 5 ~ 8 parts, the Herba Artemisiae Scopariae of 20 ~ 30 parts and 5 ~ 8 parts of additives, this additive is xylitol, dextrin, the mixture of calcium hydrogen phosphate and citric acid,
This Chinese medicine is prepared through the following steps:
According to toothbrush grass, Fructus Liquidambaris, stir-baked RHIIZOMA CURCUMAE with vinegar and gynostemma pentaphyllum makino that above-mentioned weight portion takes rinsing oven dry or dries, mix homogeneously, drying 30 ~ 40 minutes at 55 ~ 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 60 ~ 70 mesh sieves; Then at 65 ~ 75 DEG C dry 20 ~ 30 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 40 ~ 60 minutes, then put it in ultrafine crusher the fine powder being ground into 200 ~ 220 mesh sieves, and mix homogeneously;
2) what take above-mentioned weight portion solely shakes grass, Radix Salviae Miltiorrhizae, water Rhizoma Acori Graminei and Herba Renantherae coccineae mix homogeneously, drying 15 ~ 20 minutes at 55 ~ 65 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 70 ~ 80 mesh sieves; Add and solely shake the weight of grass, Radix Salviae Miltiorrhizae, water Rhizoma Acori Graminei and Herba Renantherae coccineae and the mass concentration of 2.5 times is that the ethanol of 70 ~ 75% is 50 ~ 60 DEG C of heating, reflux, extract, 3 times, each 1.5 ~ 2.5 hours, by obtained ethanol extract, being concentrated into liquor strength 55 ~ 65 DEG C of heating is 0.3g crude drug/ml, be dried to powder, obtain alcohol extraction xeraphium for subsequent use;
3) Radix Paeoniae Rubra, Hirudo and Herba Artemisiae Scopariae are added the water of 5 ~ 6 times amount, heated and boiled 2 ~ 3 hours, extract; Add the water of 5 times amount again, heated and boiled 1 ~ 2 hour, extract; Merge extracted twice liquid, filter, filtrate is condensed into the thick paste of relative density 1.13 ~ 1.15 at 60 DEG C, for subsequent use;
4) Radix Et Rhizoma Rhei and stone Fructus Piperis are cleaned, chopping, mashes, adds the distilled water of 5 ~ 6 times amount, stir, and filters, taking juice, for subsequent use;
5) by step 1) ~ 4) products therefrom and described additive fully mix, be pressed into tablet, obtain final product.
2. the Chinese medicine for the treatment of cerebral infarction disease according to claim 1, is characterized in that this Chinese medicine is made up of following raw material by weight: the toothbrush of 28 parts grass, 12 parts Fructus Liquidambaris, 23 parts stone Fructus Piperis, 22 parts gynostemma pentaphyllum makino, 10 parts solely shake grass, the Radix Salviae Miltiorrhizae of 30 parts, the water Rhizoma Acori Graminei of 17 parts, the Herba Renantherae coccineae of 8 parts, the Radix Et Rhizoma Rhei of 7 parts, the stir-baked RHIIZOMA CURCUMAE with vinegar of 13 parts, the Radix Paeoniae Rubra of 7 parts, the Hirudo of 6 parts, the Herba Artemisiae Scopariae of 25 parts and 7 parts of additives.
3. the Chinese medicine for the treatment of cerebral infarction disease according to claim 1 and 2, is characterized in that 1 part of described raw material weight for 10g.
4. the Chinese medicine for the treatment of cerebral infarction disease according to claim 3, is characterized in that the weight ratio of xylitol, dextrin, calcium hydrogen phosphate and citric acid in described additive is 1:0.5:1:0.5.
5. the Chinese medicine for the treatment of cerebral infarction disease according to claim 4, is characterized in that described ultrafine crusher CF air flow super machine.
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| CN105267676A (en) * | 2015-10-16 | 2016-01-27 | 鞠进英 | Nursing medicine liquid for treating burns and scalds and method for preparing nursing medicine liquid |
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|---|---|---|---|---|
| CN101116712A (en) * | 2007-03-26 | 2008-02-06 | 董春玲 | Drug for curing cerebral infarction --- liquid for promoting blood circulation and removing blood stasis |
| CN101690764A (en) * | 2009-09-30 | 2010-04-07 | 卢速江 | Traditional Chinese medicine for treating cardiac, cerebral and vascular diseases and preparation method thereof |
| CN103393943A (en) * | 2013-08-01 | 2013-11-20 | 戴江英 | Traditional Chinese medicine composition for treating sequela of cerebral infarction |
| CN103705761A (en) * | 2014-01-14 | 2014-04-09 | 刘国远 | Traditional Chinese medicine for treating cerebral hemorrhage diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101116712A (en) * | 2007-03-26 | 2008-02-06 | 董春玲 | Drug for curing cerebral infarction --- liquid for promoting blood circulation and removing blood stasis |
| CN101690764A (en) * | 2009-09-30 | 2010-04-07 | 卢速江 | Traditional Chinese medicine for treating cardiac, cerebral and vascular diseases and preparation method thereof |
| CN103393943A (en) * | 2013-08-01 | 2013-11-20 | 戴江英 | Traditional Chinese medicine composition for treating sequela of cerebral infarction |
| CN103705761A (en) * | 2014-01-14 | 2014-04-09 | 刘国远 | Traditional Chinese medicine for treating cerebral hemorrhage diseases |
Non-Patent Citations (1)
| Title |
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| 饶旺福等: "中医治疗中风病进展", 《江西中医药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267676A (en) * | 2015-10-16 | 2016-01-27 | 鞠进英 | Nursing medicine liquid for treating burns and scalds and method for preparing nursing medicine liquid |
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