CN105267653A - Externally-used preparation treating osteoporosis and preparation method - Google Patents
Externally-used preparation treating osteoporosis and preparation method Download PDFInfo
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Abstract
The invention discloses an externally-used preparation treating osteoporosis and a preparation method. The preparation is prepared mainly from the following bulk drugs in parts by mass: 8-14 parts of radix astragali, 9-13 parts of himalayan teasel root, 7-12 parts of mengtzu indigo, 10-14 parts of fragrant solomonseal rhizome, 5-9 parts of herb of sibirica walking fern, 8-13 parts of Japanese ardisia herb, 7-14 parts of root of wallich swallowwort, 6-12 parts of root of perny germander, 10-15 parts of semen cuscutae, 8-15 parts of leaf of falsesour cherry, 9-14 parts of fruit of chinese holly, 7-13 parts of root of longflower stringbush, 9-16 parts of cortex cinnamomi, 6-9 parts of common lamiophlomis, and 8-12 parts of herb of big striga. The preparation is prepared by selecting traditional Chinese medicine materials, gives play to efficacies by permeating skin, and does not cause any toxic and side effects on human body. The prescription completely accords with traditional Chinese medicine principles, is capable of giving play to effects of fortifying kidney and reinforcing bond, activating blood and freeing collateral vessels, dissipating cold and relieving pain, and the like, and is good in curative effect, high in safety, extensive in applicability, and small in economic pressure after being used for a long time.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the osteoporotic external preparation of a kind for the treatment of and method for making.
Background technology
Osteoporosis is a kind of systemic osteopathia, and with Low BMD and osseous tissue Microstructure Fracture for feature, the fragility showing as bone increases, and the danger of thus fracturing greatly increases, even also easily fracture in slight wound or atraumatic situation.Osteoporosis is a kind of multifactor caused chronic disease.Before fracture occurs, usually without Special Clinical Manifestation.This sick women, more than male, is common in postmenopausal women and old people.But each period at age all can fall ill.Osteoporosis can be divided into constitutional and Secondary cases two class.Primary osteoporosis means other illness of not accompanying and causing primary disease; Secondary osteoporosis is then that the osseous tissue amount caused due to various general or endocrine metabolism disease reduces.In addition, limitation or general property osteoporosis can be also divided into by happening part.The modal disease disease of primary osteoporosis, common with lumbago and backache, account for the 70%-80% in pain patients, pain spreads along spinal column to both sides, lie on the back or seat time pain relief, stretch after time upright or standing for a long time, during sitting, the pain increased, in the daytime pain is light, night and early morning increase the weight of when waking up, and bend over, muscular movement, cough, increases the weight of when stool exerts oneself.There will be hunchback after pain, osteoporosis is heavier more, and bow-backed curvature is larger.Also there will be fracture, degradation symptom under respiratory function.
Publication No. CN103977075A(application number 201410184948.7) Chinese patent literature disclose for preventing and treating osteoporotic Chinese medicine application preparation, the weight ratio of raw material is Rhizoma Cibotii: Herba Epimedii: Cortex Cinnamomi=2:2:1.Publication No. CN103463553A(application number 201310219613.X) Chinese patent literature disclose one and treat osteoporotic external-applied ointment and preparation method thereof, consist of Fructus Psoraleae 20-30, Radix Rehmanniae Preparata 10-15, Radix Salviae Miltiorrhizae 10-15, Cortex Moutan 10-14, Radix Astragali 10-12, Herba Epimedii 15-20, Radix Aconiti 4-6, Rhizoma Et Radix Notopterygii 10-12, Myrrha 8-10, Rhizoma Curcumae Longae 5-7, Herba Lycopi 10-12, Rhizoma Dioscoreae Nipponicae 6-10, Flos Carthami 4-8, Cortex Acanthopancis 10-13, Radix Angelicae Pubescentis 6-8, Semen Sinapis Albae 7-10, Herba Lycopodii 10-13, Rhizoma Corydalis 10-20, Caulis Kadsurae Longipedunculatae 10-13, Radix et Bulbus Allii tuberosi 10-12, eupolyphaga 8-10.
Many kinds are had about the osteoporotic Western medicine for the treatment of, but these medicines of long-term taking, obvious side effect can be produced, and costly, effect varies with each individual, and at present the osteoporotic Chinese medicine formula of associated therapy is also less, therefore can develop one safely and effectively Chinese medicine preparation solve patient suffering.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of safe and effective, the preparation simply osteoporotic external preparation for the treatment of and method for making.
Technical scheme of the present invention is:
The osteoporotic external preparation of a kind for the treatment of, is prepared from primarily of following bulk drugs, is mass parts: Radix Astragali 8-14, Radix Dipsaci 9-13, Indigofera mentzeana Craib 7-12, Rhizoma Polygonati Odorati 10-14, Herba Camptosori Sibirici 5-9, PINGDIMU 8-13, Radix cynanchi wallichii 7-14, Radix Teucrii Pernyi 6-12, Semen Cuscutae 10-15, Folium Pruni pseudocerasi 8-15, Fructus Ilicis Cornutae 9-14, Radix Wikstroemiae Dolichanthae 7-13, Cortex Cinnamomi 9-16, Radix Lamiophlomidis Rotatae 6-9, Herba Strigae masuriae 8-12.
In preferred scheme, Radix Astragali 10-12, Radix Dipsaci 10-12, Indigofera mentzeana Craib 8-11, Rhizoma Polygonati Odorati 11-13, Herba Camptosori Sibirici 6-8, PINGDIMU 9-12, Radix cynanchi wallichii 9-12, Radix Teucrii Pernyi 8-10, Semen Cuscutae 11-14, Folium Pruni pseudocerasi 10-13, Fructus Ilicis Cornutae 10-13, Radix Wikstroemiae Dolichanthae 9-11, Cortex Cinnamomi 11-14, Radix Lamiophlomidis Rotatae 7-8, Herba Strigae masuriae 9-11.
Be more preferably, the Radix Astragali 11, Radix Dipsaci 11, Indigofera mentzeana Craib 9.5, Rhizoma Polygonati Odorati 12, Herba Camptosori Sibirici 7, PINGDIMU 10.5, Radix cynanchi wallichii 10.5, Radix Teucrii Pernyi 9, Semen Cuscutae 12.5, Folium Pruni pseudocerasi 11.5, Fructus Ilicis Cornutae 11.5, Radix Wikstroemiae Dolichanthae 10, Cortex Cinnamomi 12.5, Radix Lamiophlomidis Rotatae 7.5, Herba Strigae masuriae 10.
The preparation method of described external preparation, step is:
(1) by the wooden roguing pacifically of Radix Dipsaci, Indigofera mentzeana Craib, be placed in refractory container, be heated to surface coke black, take out, be placed in yellow wine, big fire is boiled 5-10 minute (preferred, big fire boils 7.5 minutes), takes out, dries;
(2) get Semen Cuscutae and Fructus Ilicis Cornutae roguing, spray rice wine mix thoroughly with Oryza glutinosa is same after frying 5 minutes, stir-fry to Oryza glutinosa in time yellow, take out, sieve removes Oryza glutinosa, dries in the air cool;
(3) by Cortex Cinnamomi and bean curd with boiling, well-done rear taking-up, drying in the air coolly scrapes off rough bark, smashs to pieces, adds brown sugar water and mix thoroughly, be placed in frying pan together with the Radix Wikstroemiae Dolichanthae soaked into clear water, and slow fire adds to propagandize hotly and takes out to dry tack free, dries;
(4) Radix Astragali, Rhizoma Polygonati Odorati, Radix cynanchi wallichii, Radix Teucrii Pernyi and Radix Lamiophlomidis Rotatae and step (1) (3) made crude drug are added Chinese liquor and flood 4-6 hour (preferably, steeping in wine stain 5 hours), sucking filtration, obtain medicated wine, residue filtering residue adds decocting in water, after intense fire boils, 25-37 at a simmer minute (preferred, 27-35 minute at a simmer; Be more preferably, 31 minutes at a simmer), obtain medicinal liquid, and medicinal liquid is mixed with medicated wine;
(5) Herba Camptosori Sibirici, Folium Pruni pseudocerasi and Herba Strigae masuriae are pulverized together with step (2) made crude drug, join in step (4) made mixed liquor, heating is boiled into clear paste, obtains external preparation.
The preparation method of described external preparation, the amount of step (1) yellow wine be Radix Dipsaci, Indigofera mentzeana Craib pacifically wooden gross mass 4-5 doubly (preferred, the amount of yellow wine is 4.5 times of Radix Dipsaci, Indigofera mentzeana Craib wooden gross mass pacifically).
The preparation method of described external preparation, the amount of step (2) rice wine is the 2-4 of Semen Cuscutae and Fructus Ilicis Cornutae gross mass doubly (preferred, the amount of rice wine is 3 times of Semen Cuscutae and Fructus Ilicis Cornutae gross mass).
The preparation method of described external preparation, the 3-4 that the amount of step (4) Chinese liquor is institute's impregnated raw material medicine quality is (preferred, 3.5 times that the amount of Chinese liquor is institute's impregnated raw material medicine quality) doubly.
The preparation method of described external preparation, step (4) amount of water is that doubly (preferred, amount of water is 5-6 times of filtering residue quality to the 4-7 of filtering residue quality; Be more preferably, amount of water is 5.5 times of filtering residue quality).
The preparation method of described external preparation, step (5) was pulverized 180-300 mesh sieve and (preferably, was pulverized 220-260 mesh sieve; Be more preferably, pulverized 240 mesh sieves).
Present invention also offers and described a kind ofly cure the application of osteoporotic external preparation when preparing the osteoporotic medicine for the treatment of.
One provided by the invention cures osteoporotic external preparation scientific formulation, and preparation is simple, use safety.In addition, excellent results of the present invention also shows:
1, the present invention selects Chinese medicine material to make, and infiltrates skin and plays effect, without any side effects to body;
2, this prescription meets Chinese medicine principle completely, can play the effects such as strong kidney bone strengthening, promoting blood circulation to remove obstruction in the collateral, dispersing cold for relieving pain;
3, good effect of the present invention, safety is high, and the suitability is wide, and life-time service economic pressures are little.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
The Radix Astragali: base is former: be the root of leguminous plant Radix Astagali.Nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting., chronic diarrhea proctoptosis, spontaneous perspiration, edema weak for the deficiency of vital energy, sub-official prolapsus, chronic nephritis proteinuria, diabetes, open sore part disunion of a specified duration.
Radix Dipsaci: base is former: be the root of Radix Dipsaci kind of plant Radix Dipsaci or Radix Dipsaci.Nature and flavor: bitter, pungent, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.For soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.
Indigofera mentzeana Craib: base is former: be the root of leguminous plant Indigofera mentzeana Craib.Nature and flavor: bitter, pungent, flat, mild toxicity.Gui Jing: lung, urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral.Main pneumonia, pertussis, acute gastroenteritis, nephritis, gingivitis, otitis media, vasculitis, osteomyelitis, sore swollen toxin, traumatic injury, rheumatic arthralgia.
Rhizoma Polygonati Odorati: base is former: be the rhizome of liliaceous plant Rhizoma Polygonati Odorati.Nature and flavor: sweet, are slightly cold.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.
Herba Camptosori Sibirici: base is former: be the herb of Aspleniaceae plant walking fern.Nature and flavor: light are flat.Function cures mainly: hemostasis, antiinflammatory.Control traumatic hemorrhage, metrorrhagia.
PINGDIMU: base is former: be the Herb of Myrsinacea plant PINGDIMU.Nature and flavor: pungent, micro-hardship, property is put down.Gui Jing: lung, Liver Channel.Function cures mainly: preventing phlegm from forming and stopping coughing, and dampness removing is invigorated blood circulation.Main new chronic cough is coughed, sputum mixed with blood, jaundice, edema, stranguria, leucorrhea, amenorrhea dysmenorrhea, rheumatic arthralgia, traumatic injury, painful and swollen testis.
Radix cynanchi wallichii: base is former: be the root of asclepiadaceae plant Cynanchum Wallichii.Nature and flavor: sweet micro-hardship, temperature.Function cures mainly: strengthening the loins and invigorating the kidney, bone and muscle strengthening, removing toxic substances.
Radix Teucrii Pernyi: base is former: for labiate spends the root of Phryganeajaponica Ml. in vain.Nature and flavor: acrid in the mouth, micro-sweet, property is put down.Gui Jing: return spleen, stomach warp.Function cures mainly: dispel the wind, dampness removing, removing toxic substances.Main flu, headache, nasal obstruction, dysentery, eczema, white macula.
Semen Cuscutae: base is former: be the seed of convolvulus cuscuta plant or cuscuta japonica Choisy.Nature and flavor: sweet, temperature.Gui Jing: return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down, externally treating leucoderma.
Folium Pruni pseudocerasi: base is former: be the blade of rosaceous plant Fructus Pruni pseudocerasi.Nature and flavor: sweetness and bitterness, temperature.Gui Jing: enter liver, spleen two warp.Function cures mainly: stomach warming, spleen invigorating, hemostasis, removing toxic substances.Control cold syndrome of the stomach food stagnation, diarrhoea, spit blood, sore.
Fructus Ilicis Cornutae: base is former: be the fruit of holly plant Ilex cornuta Lindl..Nature and flavor: bitter, puckery, tepor.Function cures mainly: the astringent or styptic treatment for spontaneous sweating part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.For leukorrhagia, chronic diarrhea.
Radix Wikstroemiae Dolichanthae: base is former: for Isolated From Thymelaeaceae Species one is the root of perfume (or spice).Nature and flavor: sweet light are flat.Function cures mainly: spleen invigorating, tonify deficiency. and control insufficiency of the spleen stomach weak, loose stool, the deficiency of vital energy swells lingering.
Cortex Cinnamomi: base is former: be dried bark and the branch skin of canella Cortex Cinnamomi.Nature and flavor: pungent, sweet are warm greatly.Gui Jing: return kidney, spleen, the heart, Liver Channel.Function cures mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Radix Lamiophlomidis Rotatae: base is former: be root and rhizome or the herb of lip kind of plant Radix Lamiophlomidis Rotatae.Nature and flavor: bitter, are slightly cold.Function cures mainly: invigorate blood circulation, clots absorbing, detumescence, hemostasis.Control and get injured by a fall muscles and bones, sprain one's back and frustrate gas, yellow fluid is amassed in joint.
Herba Strigae masuriae: base is former: be the herb of the large Herba Lobeliae Chinensis of goatweed.Nature and flavor: light, cool.Function cures mainly: heat clearing away eliminating dampness by diuresis, diuresis.Control cystitis, urethritis, nephritis, icterohepatitis, cirrhotic ascites.
embodiment 1the osteoporotic external preparation of a kind for the treatment of, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Astragali 8 parts, Radix Dipsaci 9 parts, Indigofera mentzeana Craib 7 parts, Rhizoma Polygonati Odorati 10 parts, Herba Camptosori Sibirici 5 parts, PINGDIMU 8 parts, Radix cynanchi wallichii 7 parts, Radix Teucrii Pernyi 6 parts, Semen Cuscutae 10 parts, Folium Pruni pseudocerasi 8 parts, Fructus Ilicis Cornutae 9 parts, Radix Wikstroemiae Dolichanthae 7 parts, Cortex Cinnamomi 9 parts, Radix Lamiophlomidis Rotatae 6 parts, Herba Strigae masuriae 8 parts.
Above-mentioned a kind of preparation method curing osteoporotic external preparation is:
(1) by the wooden roguing pacifically of Radix Dipsaci, Indigofera mentzeana Craib, be placed in refractory container, be heated to surface coke black, take out, to be placed in yellow wine (amount of yellow wine is 4 times of Radix Dipsaci, Indigofera mentzeana Craib wooden gross mass pacifically), big fire boils 5 minutes, takes out, dries;
(2) get Semen Cuscutae and Fructus Ilicis Cornutae roguing, spray rice wine mix thoroughly (amount of rice wine is 2 times of Semen Cuscutae and Fructus Ilicis Cornutae gross mass) with Oryza glutinosa is same after frying 5 minutes, stir-fry to Oryza glutinosa in time yellow, take out, sieve removes Oryza glutinosa, dries in the air cool;
(3) by Cortex Cinnamomi and bean curd with boiling, well-done rear taking-up, drying in the air coolly scrapes off rough bark, smashs to pieces, adds brown sugar water and mix thoroughly, be placed in frying pan together with the Radix Wikstroemiae Dolichanthae soaked into clear water, and slow fire adds to propagandize hotly and takes out to dry tack free, dries;
(4) Radix Astragali, Rhizoma Polygonati Odorati, Radix cynanchi wallichii, Radix Teucrii Pernyi and Radix Lamiophlomidis Rotatae and step (1) (3) made crude drug are added Chinese liquor to flood 4 hours (3 times that the amount of Chinese liquor is institute's impregnated raw material medicine quality), sucking filtration, obtain medicated wine, residue filtering residue adds decocting in water, amount of water is 4 times of filtering residue quality, after intense fire boils, 25 minutes at a simmer, obtain medicinal liquid, and medicinal liquid is mixed with medicated wine;
(5) Herba Camptosori Sibirici, Folium Pruni pseudocerasi and Herba Strigae masuriae were pulverized 180 mesh sieves together with step (2) made crude drug, and joined in step (4) made mixed liquor, heating is boiled into clear paste, obtains external preparation.
embodiment 2the osteoporotic external preparation of a kind for the treatment of, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Astragali 14 parts, Radix Dipsaci 13 parts, Indigofera mentzeana Craib 12 parts, Rhizoma Polygonati Odorati 14 parts, Herba Camptosori Sibirici 9 parts, PINGDIMU 13 parts, Radix cynanchi wallichii 14 parts, Radix Teucrii Pernyi 12 parts, Semen Cuscutae 15 parts, Folium Pruni pseudocerasi 15 parts, Fructus Ilicis Cornutae 14 parts, Radix Wikstroemiae Dolichanthae 13 parts, Cortex Cinnamomi 16 parts, Radix Lamiophlomidis Rotatae 9 parts, Herba Strigae masuriae 12 parts.
A kind of preparation method curing osteoporotic external preparation is:
(1) by the wooden roguing pacifically of Radix Dipsaci, Indigofera mentzeana Craib, be placed in refractory container, be heated to surface coke black, take out, to be placed in yellow wine (amount of yellow wine is 5 times of Radix Dipsaci, Indigofera mentzeana Craib wooden gross mass pacifically), big fire boils 10 minutes, takes out, dries;
(2) get Semen Cuscutae and Fructus Ilicis Cornutae roguing, spray rice wine mix thoroughly (amount of rice wine is 4 times of Semen Cuscutae and Fructus Ilicis Cornutae gross mass) with Oryza glutinosa is same after frying 5 minutes, stir-fry to Oryza glutinosa in time yellow, take out, sieve removes Oryza glutinosa, dries in the air cool;
(3) by Cortex Cinnamomi and bean curd with boiling, well-done rear taking-up, drying in the air coolly scrapes off rough bark, smashs to pieces, adds brown sugar water and mix thoroughly, be placed in frying pan together with the Radix Wikstroemiae Dolichanthae soaked into clear water, and slow fire adds to propagandize hotly and takes out to dry tack free, dries;
(4) Radix Astragali, Rhizoma Polygonati Odorati, Radix cynanchi wallichii, Radix Teucrii Pernyi and Radix Lamiophlomidis Rotatae and step (1) (3) made crude drug are added Chinese liquor to flood 6 hours (4 times that the amount of Chinese liquor is institute's impregnated raw material medicine quality), sucking filtration, obtain medicated wine, residue filtering residue adds decocting in water, amount of water is 7 times of filtering residue quality, after intense fire boils, 37 minutes at a simmer, obtain medicinal liquid, and medicinal liquid is mixed with medicated wine;
(5) Herba Camptosori Sibirici, Folium Pruni pseudocerasi and Herba Strigae masuriae were pulverized 300 mesh sieves together with step (2) made crude drug, and joined in step (4) made mixed liquor, heating is boiled into clear paste, obtains external preparation.
Model case: xxx, female, 64 years old.Main suit: half a year, cause sprained left ankle downstairs accidentally, swelling pain, examination in hospital left ankle joint avulsion fracture, hospitalization, sb.'s illness took a favorable turn, treat after 3 months, swelling is eliminated substantially, but still feels pain, weak during walking, take a turn for the better after having a rest, x-ray display osteoporosis, is diagnosed as osteoporosis.
Use the present embodiment gained one to cure osteoporotic external preparation, be applied in affected part, thickness is 2-3mm, surface coverage gauze, and adhesive tape is fixed, and within every two days, changes once, 30 days courses for the treatment of.After using two courses for the treatment of, patient's ankle pain is eliminated, and freely can walk, but can not stand for a long time, and after consolidating two courses for the treatment of of use, pain disappears completely, recovers, as in the past, to follow up a case by regular visits to patient without recurrence after 1 year.
embodiment 3the osteoporotic external preparation of a kind for the treatment of, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Astragali 10 parts, Radix Dipsaci 10 parts, Indigofera mentzeana Craib 8 parts, Rhizoma Polygonati Odorati 11 parts, Herba Camptosori Sibirici 6 parts, PINGDIMU 9 parts, Radix cynanchi wallichii 9 parts, Radix Teucrii Pernyi 8 parts, Semen Cuscutae 11 parts, Folium Pruni pseudocerasi 10 parts, Fructus Ilicis Cornutae 10 parts, Radix Wikstroemiae Dolichanthae 9 parts, Cortex Cinnamomi 11 parts, Radix Lamiophlomidis Rotatae 7 parts, Herba Strigae masuriae 9 parts.
A kind of preparation method curing osteoporotic external preparation is:
(1) by the wooden roguing pacifically of Radix Dipsaci, Indigofera mentzeana Craib, be placed in refractory container, be heated to surface coke black, take out, to be placed in yellow wine (amount of yellow wine is 4 times of Radix Dipsaci, Indigofera mentzeana Craib wooden gross mass pacifically), big fire boils 5 minutes, takes out, dries;
(2) get Semen Cuscutae and Fructus Ilicis Cornutae roguing, spray rice wine mix thoroughly (amount of rice wine is 2 times of Semen Cuscutae and Fructus Ilicis Cornutae gross mass) with Oryza glutinosa is same after frying 5 minutes, stir-fry to Oryza glutinosa in time yellow, take out, sieve removes Oryza glutinosa, dries in the air cool;
(3) by Cortex Cinnamomi and bean curd with boiling, well-done rear taking-up, drying in the air coolly scrapes off rough bark, smashs to pieces, adds brown sugar water and mix thoroughly, be placed in frying pan together with the Radix Wikstroemiae Dolichanthae soaked into clear water, and slow fire adds to propagandize hotly and takes out to dry tack free, dries;
(4) Radix Astragali, Rhizoma Polygonati Odorati, Radix cynanchi wallichii, Radix Teucrii Pernyi and Radix Lamiophlomidis Rotatae and step (1) (3) made crude drug are added Chinese liquor to flood 4 hours (3 times that the amount of Chinese liquor is institute's impregnated raw material medicine quality), sucking filtration, obtain medicated wine, residue filtering residue adds decocting in water, amount of water is 5 times of filtering residue quality, after intense fire boils, 27 minutes at a simmer, obtain medicinal liquid, and medicinal liquid is mixed with medicated wine;
(5) Herba Camptosori Sibirici, Folium Pruni pseudocerasi and Herba Strigae masuriae were pulverized 220 mesh sieves together with step (2) made crude drug, and joined in step (4) made mixed liquor, heating is boiled into clear paste, obtains external preparation.
Model case: xxx, man, 62 years old.Main suit: sore waist and aching in the waist and the back 6 years repeatedly, winter-spring season attack times increases, gradually bow-backed, knee joint is ice-cold, joint stuffiness, limbs fatigue, numbness, pain relief of lying on the back, for a long time station, sitting or when straightening one's back, the pain increased, because economic cause is not given treatment to always, nearly one month exacerbation of symptoms, handicapped, examination in hospital, x-ray display many places lumbar vertebra deformity, bone density declines obviously, is diagnosed as osteoporosis.
Take bone capsules " Weishukang " for curing and use the present embodiment gained one to cure osteoporotic external preparation, be applied in affected part, thickness is 2-3mm, surface coverage gauze, and adhesive tape is fixed, and within every two days, changes once, 30 days courses for the treatment of.After using 2 courses for the treatment of, aching pain in waist and back alleviates, and knee joint turns temperature, after using four courses for the treatment of, patient can freely walk, but the time can not be long, and extremity sensation is strong, after using six courses for the treatment of, lumbago and backache is eliminated substantially, and life can be taken care of oneself, rehabilitation, and it is in good condition to follow up a case by regular visits to patient body after 1 year.
embodiment 4the osteoporotic external preparation of a kind for the treatment of, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Astragali 12 parts, Radix Dipsaci 12 parts, Indigofera mentzeana Craib 11 parts, Rhizoma Polygonati Odorati 13 parts, Herba Camptosori Sibirici 8 parts, PINGDIMU 12 parts, Radix cynanchi wallichii 12 parts, Radix Teucrii Pernyi 10 parts, Semen Cuscutae 14 parts, Folium Pruni pseudocerasi 13 parts, Fructus Ilicis Cornutae 13 parts, Radix Wikstroemiae Dolichanthae 11 parts, Cortex Cinnamomi 14 parts, Radix Lamiophlomidis Rotatae 8 parts, Herba Strigae masuriae 11 parts.
A kind of preparation method curing osteoporotic external preparation is:
(1) by the wooden roguing pacifically of Radix Dipsaci, Indigofera mentzeana Craib, be placed in refractory container, be heated to surface coke black, take out, to be placed in yellow wine (amount of yellow wine is 5 times of Radix Dipsaci, Indigofera mentzeana Craib wooden gross mass pacifically), big fire boils 10 minutes, takes out, dries;
(2) get Semen Cuscutae and Fructus Ilicis Cornutae roguing, spray rice wine mix thoroughly (amount of rice wine is 4 times of Semen Cuscutae and Fructus Ilicis Cornutae gross mass) with Oryza glutinosa is same after frying 5 minutes, stir-fry to Oryza glutinosa in time yellow, take out, sieve removes Oryza glutinosa, dries in the air cool;
(3) by Cortex Cinnamomi and bean curd with boiling, well-done rear taking-up, drying in the air coolly scrapes off rough bark, smashs to pieces, adds brown sugar water and mix thoroughly, be placed in frying pan together with the Radix Wikstroemiae Dolichanthae soaked into clear water, and slow fire adds to propagandize hotly and takes out to dry tack free, dries;
(4) Radix Astragali, Rhizoma Polygonati Odorati, Radix cynanchi wallichii, Radix Teucrii Pernyi and Radix Lamiophlomidis Rotatae and step (1) (3) made crude drug are added Chinese liquor to flood 6 hours (4 times that the amount of Chinese liquor is institute's impregnated raw material medicine quality), sucking filtration, obtain medicated wine, residue filtering residue adds decocting in water, amount of water is 6 times of filtering residue quality, after intense fire boils, 35 minutes at a simmer, obtain medicinal liquid, and medicinal liquid is mixed with medicated wine;
(5) Herba Camptosori Sibirici, Folium Pruni pseudocerasi and Herba Strigae masuriae were pulverized 260 mesh sieves together with step (2) made crude drug, and joined in step (4) made mixed liquor, heating is boiled into clear paste, obtains external preparation.
embodiment 5the osteoporotic external preparation of a kind for the treatment of, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Astragali 11 parts, Radix Dipsaci 11 parts, Indigofera mentzeana Craib 9.5 parts, Rhizoma Polygonati Odorati 12 parts, Herba Camptosori Sibirici 7 parts, PINGDIMU 10.5 parts, Radix cynanchi wallichii 10.5 parts, Radix Teucrii Pernyi 9 parts, Semen Cuscutae 12.5 parts, Folium Pruni pseudocerasi 11.5 parts, Fructus Ilicis Cornutae 11.5 parts, Radix Wikstroemiae Dolichanthae 10 parts, Cortex Cinnamomi 12.5 parts, Radix Lamiophlomidis Rotatae 7.5 parts, Herba Strigae masuriae 10 parts.
A kind of preparation method curing osteoporotic external preparation is:
(1) by the wooden roguing pacifically of Radix Dipsaci, Indigofera mentzeana Craib, be placed in refractory container, be heated to surface coke black, take out, to be placed in yellow wine (amount of yellow wine is 4.5 times of Radix Dipsaci, Indigofera mentzeana Craib wooden gross mass pacifically), big fire boils 7.5 minutes, takes out, dries;
(2) get Semen Cuscutae and Fructus Ilicis Cornutae roguing, spray rice wine mix thoroughly (amount of rice wine is 3 times of Semen Cuscutae and Fructus Ilicis Cornutae gross mass) with Oryza glutinosa is same after frying 5 minutes, stir-fry to Oryza glutinosa in time yellow, take out, sieve removes Oryza glutinosa, dries in the air cool;
(3) by Cortex Cinnamomi and bean curd with boiling, well-done rear taking-up, drying in the air coolly scrapes off rough bark, smashs to pieces, adds brown sugar water and mix thoroughly, be placed in frying pan together with the Radix Wikstroemiae Dolichanthae soaked into clear water, and slow fire adds to propagandize hotly and takes out to dry tack free, dries;
(4) Radix Astragali, Rhizoma Polygonati Odorati, Radix cynanchi wallichii, Radix Teucrii Pernyi and Radix Lamiophlomidis Rotatae and step (1) (3) made crude drug are added Chinese liquor to flood 5 hours (3.5 times that the amount of Chinese liquor is institute's impregnated raw material medicine quality), sucking filtration, obtain medicated wine, residue filtering residue adds decocting in water, amount of water is 5.5 times of filtering residue quality, after intense fire boils, 31 minutes at a simmer, obtain medicinal liquid, and medicinal liquid is mixed with medicated wine;
(5) Herba Camptosori Sibirici, Folium Pruni pseudocerasi and Herba Strigae masuriae were pulverized 240 mesh sieves together with step (2) made crude drug, and joined in step (4) made mixed liquor, heating is boiled into clear paste, obtains external preparation.
test example 1gained one of the present invention cures the clinical practice of osteoporotic external preparation (embodiment 5):
In November ,-2014 in May, 2012, in the patients with primary osteoporosis of 3 hospital therapies, filter out 292 routine patients, wherein women 168 example, male 124 example, age 49-73 year, the mean age (57.4 ± 5.2) year, course of disease 1-10.
Patient is divided into two groups at random, experimental group 162 example and matched group 130 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Matched group takes calcium carbonate D3 chewable tablet, and experimental group, while taking calcium carbonate D3 chewable tablet, uses products obtained therefrom of the present invention, is applied in affected part, thickness is 2-3mm, surface coverage gauze, and adhesive tape is fixed, within every two days, change once, 30 days courses for the treatment of, treat 4 courses for the treatment of continuously.Treatments period carries out Continuous Observation to two groups of patients, record symptom and BMD value (bone density) change.
Curative effect situation criterion: effective: the clinical symptoms such as aching pain in waist and back disappear substantially, BMD value rises before comparatively treating; Effective: the clinical symptom reliefs such as aching pain in waist and back, BMD value is comparatively treated front without declining; Invalid: after treatment, malaise symptoms is without improvement, BMD value declines before comparatively treating.Total effective rate=(effective example+effectively example)/total number of cases × 100%
After the treatment of four courses for the treatment of, effective 91 examples in experimental group patient, effective 65 examples, invalid 6 examples, experimental group total effective rate is 96.3%.In matched group, effective 27 examples, effective 58 examples, invalid 45 examples, matched group total effective rate is 65.4%, and therapeutic effect is obviously better than matched group.
Before and after two groups of treatments, the change of BMD value is more as shown in table 1.
Before and after table 1 liang group treatment, the change of BMD value is compared
As shown in Table 1, raising through treating before two groups of patient B MD meansigma methodss are all comparatively treated, after treatment, compared with the BMD meansigma methods of experimental group BMD meansigma methods that is front with treatment and matched group after treating, all there is significant difference (P < 0.05).
The present invention selects Radix Astragali invigorating QI to consolidate the body surface resistance, Radix Dipsaci bone and muscle strengthening, Indigofera mentzeana Craib promoting blood circulation to remove obstruction in the collateral, Rhizoma Polygonati Odorati nourishing YIN to relieve dryness, Herba Camptosori Sibirici hemostasis and anti-inflammation, PINGDIMU preventing phlegm from forming and stopping coughing, Radix cynanchi wallichii strengthening the loins and invigorating the kidney, Radix Teucrii Pernyi expelling wind and removing dampness, Semen Cuscutae nourishing the liver and kidney, the spleen invigorating of Folium Pruni pseudocerasi stomach warming, the astringent or styptic treatment for spontaneous sweating part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels of Fructus Ilicis Cornutae, Radix Wikstroemiae Dolichanthae spleen invigorating tonify deficiency, Cortex Cinnamomi dispersing cold for relieving pain, Radix Lamiophlomidis Rotatae blood circulation promoting competent silt, Herba Strigae masuriae heat clearing away eliminating dampness by diuresis, multiple medical material science collocation, the effects such as strong kidney bone strengthening, promoting blood circulation to remove obstruction in the collateral, dispersing cold for relieving pain can be played, strengthen bone conversion, improve bone density, prevent the generation of fracturing.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. cure an osteoporotic external preparation, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Radix Astragali 8-14, Radix Dipsaci 9-13, Indigofera mentzeana Craib 7-12, Rhizoma Polygonati Odorati 10-14, Herba Camptosori Sibirici 5-9, PINGDIMU 8-13, Radix cynanchi wallichii 7-14, Radix Teucrii Pernyi 6-12, Semen Cuscutae 10-15, Folium Pruni pseudocerasi 8-15, Fructus Ilicis Cornutae 9-14, Radix Wikstroemiae Dolichanthae 7-13, Cortex Cinnamomi 9-16, Radix Lamiophlomidis Rotatae 6-9, Herba Strigae masuriae 8-12.
2. the osteoporotic external preparation of a kind for the treatment of as claimed in claim 1, is characterized in that, Radix Astragali 10-12, Radix Dipsaci 10-12, Indigofera mentzeana Craib 8-11, Rhizoma Polygonati Odorati 11-13, Herba Camptosori Sibirici 6-8, PINGDIMU 9-12, Radix cynanchi wallichii 9-12, Radix Teucrii Pernyi 8-10, Semen Cuscutae 11-14, Folium Pruni pseudocerasi 10-13, Fructus Ilicis Cornutae 10-13, Radix Wikstroemiae Dolichanthae 9-11, Cortex Cinnamomi 11-14, Radix Lamiophlomidis Rotatae 7-8, Herba Strigae masuriae 9-11.
3. the osteoporotic external preparation of a kind for the treatment of as claimed in claim 1, is characterized in that, the Radix Astragali 11, Radix Dipsaci 11, Indigofera mentzeana Craib 9.5, Rhizoma Polygonati Odorati 12, Herba Camptosori Sibirici 7, PINGDIMU 10.5, Radix cynanchi wallichii 10.5, Radix Teucrii Pernyi 9, Semen Cuscutae 12.5, Folium Pruni pseudocerasi 11.5, Fructus Ilicis Cornutae 11.5, Radix Wikstroemiae Dolichanthae 10, Cortex Cinnamomi 12.5, Radix Lamiophlomidis Rotatae 7.5, Herba Strigae masuriae 10.
4. the preparation method of the external preparation as described in as arbitrary in claim 1-3, it is characterized in that, step is:
(1) by the wooden roguing pacifically of Radix Dipsaci, Indigofera mentzeana Craib, be placed in refractory container, be heated to surface coke black, take out, be placed in yellow wine, big fire is boiled 5-10 minute (preferred, big fire boils 7.5 minutes), takes out, dries;
(2) get Semen Cuscutae and Fructus Ilicis Cornutae roguing, spray rice wine mix thoroughly with Oryza glutinosa is same after frying 5 minutes, stir-fry to Oryza glutinosa in time yellow, take out, sieve removes Oryza glutinosa, dries in the air cool;
(3) by Cortex Cinnamomi and bean curd with boiling, well-done rear taking-up, drying in the air coolly scrapes off rough bark, smashs to pieces, adds brown sugar water and mix thoroughly, be placed in frying pan together with the Radix Wikstroemiae Dolichanthae soaked into clear water, and slow fire adds to propagandize hotly and takes out to dry tack free, dries;
(4) Radix Astragali, Rhizoma Polygonati Odorati, Radix cynanchi wallichii, Radix Teucrii Pernyi and Radix Lamiophlomidis Rotatae and step (1) (3) made crude drug are added Chinese liquor and flood 4-6 hour (preferably, steeping in wine stain 5 hours), sucking filtration, obtain medicated wine, residue filtering residue adds decocting in water, after intense fire boils, 25-37 at a simmer minute (preferred, 27-35 minute at a simmer; Be more preferably, 31 minutes at a simmer), obtain medicinal liquid, and medicinal liquid is mixed with medicated wine;
(5) Herba Camptosori Sibirici, Folium Pruni pseudocerasi and Herba Strigae masuriae are pulverized together with step (2) made crude drug, join in step (4) made mixed liquor, heating is boiled into clear paste, obtains external preparation.
5. the preparation method of external preparation as claimed in claim 4, it is characterized in that, the amount of step (1) yellow wine be Radix Dipsaci, Indigofera mentzeana Craib pacifically wooden gross mass 4-5 doubly (preferred, the amount of yellow wine is 4.5 times of Radix Dipsaci, Indigofera mentzeana Craib wooden gross mass pacifically).
6. the preparation method of external preparation as claimed in claim 4, is characterized in that, the amount of step (2) rice wine is the 2-4 of Semen Cuscutae and Fructus Ilicis Cornutae gross mass doubly (preferred, the amount of rice wine is 3 times of Semen Cuscutae and Fructus Ilicis Cornutae gross mass).
7. the preparation method of external preparation as claimed in claim 4, is characterized in that, the 3-4 that the amount of step (4) Chinese liquor is institute's impregnated raw material medicine quality is (preferred, 3.5 times that the amount of Chinese liquor is institute's impregnated raw material medicine quality) doubly.
8. the preparation method of external preparation as claimed in claim 4, is characterized in that, step (4) amount of water is that doubly (preferred, amount of water is 5-6 times of filtering residue quality to the 4-7 of filtering residue quality; Be more preferably, amount of water is 5.5 times of filtering residue quality).
9. the preparation method of external preparation as claimed in claim 4, is characterized in that, step (5) was pulverized 180-300 mesh sieve and (preferably, pulverized 220-260 mesh sieve; Be more preferably, pulverized 240 mesh sieves).
10. a kind of as described in as arbitrary in claim 1-3 cures the application of osteoporotic external preparation when preparing the osteoporotic medicine for the treatment of.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103120728A (en) * | 2011-11-21 | 2013-05-29 | 吴东红 | Chinese medicinal preparation for treating osteoporosis |
| CN103920000A (en) * | 2014-03-26 | 2014-07-16 | 泸州市中医医院 | Traditional Chinese medicine composition for treating osteoporosis and preparation method thereof |
| CN104042774A (en) * | 2014-06-23 | 2014-09-17 | 曾翠芸 | Medicine composition for treatment of osteoporosis |
| CN104689012A (en) * | 2015-03-24 | 2015-06-10 | 李光亮 | Kidney reinforcing and bone strengthening wine and making method thereof |
-
2015
- 2015-10-15 CN CN201510661527.3A patent/CN105267653A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103120728A (en) * | 2011-11-21 | 2013-05-29 | 吴东红 | Chinese medicinal preparation for treating osteoporosis |
| CN103920000A (en) * | 2014-03-26 | 2014-07-16 | 泸州市中医医院 | Traditional Chinese medicine composition for treating osteoporosis and preparation method thereof |
| CN104042774A (en) * | 2014-06-23 | 2014-09-17 | 曾翠芸 | Medicine composition for treatment of osteoporosis |
| CN104689012A (en) * | 2015-03-24 | 2015-06-10 | 李光亮 | Kidney reinforcing and bone strengthening wine and making method thereof |
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| 李七一: "《中医老年病学》", 30 September 2009 * |
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Address after: 810000 room 2-1-301, No. 71, No. 171, No. 71, East Road, Qinghai, Xining, China Applicant after: Li Tao Address before: 250014 Shandong City, Ji'nan Province, the liberation of East Road, Lixia District, No. 26 home, building 5, building 1, unit 601 Applicant before: Li Tao |
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Application publication date: 20160127 |