CN105250788A - Medicine for treating heat stroke and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating heat stroke and a preparation method thereof. The medicine for treating heat stroke is prepared from the following raw materials: leaf of herb of viscid germander, leaf of hyacinth dolichos, watermelon peel, fruit of Chinese waxgourd, lotus plumule, green bamboo leaf, corydalis bowerihemsl, singli roxbrugh rose fruit, Mongolian dandelion herb, wild chrysanthemum, purslane herb, talc, leaf of luffa, Chinese mosla herb, sweet wormwood herb, seed-coat of mung bean and common selfheal fruit-spike. The medicine disclosed by the invention is beneficial for fully decocting active ingredients in the medicinal materials into a decoction, can reduce damages to the active ingredients of the medicinal materials as much as possible, and is beneficial for improving the effect of treating the heat stroke.

Description

A kind of medicine for the treatment of heatstroke and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of heatstroke, is a kind of medicine for the treatment of heatstroke and preparation method thereof specifically.

Background technology

Heatstroke is named thermoplegia again, and refer to the body temperature regulatory function imbalance that Yin Gaowen causes, intimate heat is excessively put aside, thus initiation nervous organ is impaired.Thermoplegia is exactly severe heat stroke in the classification of heatstroke, and be a kind of fatal disease, case fatality rate is high.This disease usually occurs in summer high temperature simultaneously with the weather of high humidity.

Heatstroke is a kind of mortality emergency case, with high temperature and disturbance of consciousness for feature.Onset is gone to toward there being headache, dizzy and weak.Early stage affected organ is followed successively by brain, liver, kidney and heart.State residing for patient during morbidity and pathogenesis, be divided into two types: labour's property and non-labour's property (or typicality) thermoplegia clinically.Mainly endogenous heat production is too much in high temperature environments for labour's property; Non-labour's property mainly in high temperature environments thermoregulatory dysfunction cause heat radiation reduce.

1. labour's property thermoplegia

How to fall ill when high temperature, high humidity and calm weather carry out heavy physical labour or intense physical activity.Patient mostly is usually healthy youngster, and be engaged in heavy physical labour or strenuous exercise's a few hours sequela, about 50% patient perspires in a large number, and heart rate can reach 160 ~ 180 beats/min, and pulse pressure increases.Can be there is rhabdomyolysis, acute renal failure, liver failure, disseminated inravascular coagulation (DIC) or multiple organ dysfunction syndrome in this kind of patient, case fatality rate is higher.

2. non-labour's property thermoplegia

In high temperature environments, the old asthenia resident in city of live crowded and improper ventilation is more common in.Other high-risk group comprise schizophrenia, parkinson disease, chronic alcoholism and hemiplegia or paralytic patient.Performance skin is xeothermic and rubescent, and 84% ~ 100% case is lossless, and rectal temperature is everlasting more than 41 DEG C, reaches as high as 46.5 DEG C.Sick just expression behaviour exception or epilepsy, then occurring that delirium, stupor and pupil symmetry reduce, can there is hypotension, shock, arrhythmia and heart failure, pulmonary edema and cerebral edema in severe patient.About 5% case generation acute renal failure, can have light, moderate DIC, and after morbidity of being everlasting, 24 hours are dead.

Therapeutic modality mainly contains following several:

1. external cooling

Be intended to reduce deep body temperature rapidly.Slough patient's clothes, blow cool breeze and spray with cold water or with cool wet sheet parcel whole body.No longer recommend with frozen water soaking therapy, because the complication that hypotension and shiver with cold occur is more.But as additive method cannot lower the temperature time, also can consider the method, but now need monitor deep body temperature, frozen water need be stopped to lower the temperature, in case hypothermia once lower than 38.5 DEG C.

2. cooling in body

External cooling nonresponder, carries out stomach or irrigation of rectum with brine ice, also can carry out peritoneal lavage or hemodialysis with physiological saline solution, or lowers the temperature feeding back in body after external for autoblood cooling.

3. drug cooling

Chlorpromazine has the function of regulate body temperature maincenter, the effect of blood vessel dilating, relaxed muscle and reduction oxygen consumption.Patient can apply chlorpromazine venoclysis when there is shiver with cold, and simultaneously Monitoring of blood pressure.

4. symptomatic treatment

Easily there is pulmonary infection and decubital ulcer in comatose patient, palpus intensive care; There is provided required heat and nutrient substance to recover to impel patient, keep respiratory smooth, give oxygen uptake; Positive correction water and rock-soil coupling, maintains acid-base balance; Fluid infusion velocity is unsuitable too fast, in order to avoid inspire heart failure, the digitalis preparation that heart failure gives quick effect occurs; Application pressor agent corrects shock; Mannitol dehydration prevents and treats cerebral edema.Hormone has certain curative effect to treatment pulmonary edema, cerebral edema etc., but measures excessive easy accompanying infection, and takes corresponding remedy measures for various complication.

Comparatively lack the Chinese patent medicine for the treatment of heatstroke at present, adopt western medicine heatstroke, toxic and side effects is larger, and heatstroke also needs the conditioning carrying out a period of time after first aid, and the medicine for the treatment of heatstroke is at present only suitable for the treatment in certain stage, particularly conditioning and treating cannot be continued after symptom is obviously improved.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of medicine for the treatment of heatstroke and preparation method thereof.

For solving the problems of the technologies described above, technical scheme of the present invention is: a kind of medicine for the treatment of heatstroke, is made up of the raw material of following weight portion: 7 ~ 9 parts, Herba Teucrii Viscidi leaf, Folium Dolichoris 7 ~ 9 parts, Exocarpium Citrulli 7 ~ 9 parts, 6 ~ 8 parts, Fructus Benincasae, Plumula Nelumbinis 6 ~ 8 parts, 6 ~ 8 parts, QINGZHU leaf, flatstiped corydalis herb 7 ~ 9 parts, Fructus Rosae Normalis 6 ~ 8 parts, Herba Taraxaci 6 ~ 8 parts, Flos Chrysanthemi Indici 8 ~ 10 parts, Herba Portulacae 8 ~ 10 parts, 4 ~ 6 parts, Talcum, Folium Luffae 4 ~ 6 parts, Herba Moslae 4 ~ 6 parts, Herba Artemisiae Annuae 4 ~ 6 parts, Testa Phaseoli radiati 4 ~ 6 parts, Spica Prunellae 4 ~ 6 parts.

Present invention also offers the manufacture method of the medicine of above-mentioned treatment heatstroke, comprise the following steps:

Step one, puts into beater by Herba Teucrii Viscidi leaf, Folium Dolichoris, Exocarpium Citrulli, Fructus Benincasae, QINGZHU leaf, Folium Luffae, and it is for subsequent use that medicine slurry is made in 1100r/min making beating for 5 ~ 8 minutes;

Step 2, flatstiped corydalis herb, Herba Moslae, Talcum are ground, then put into Percolation device and carry out percolation, first carry out preliminary percolation, liquid of just filtering is the ethanol water of volumetric concentration 75% ~ 80%, and the first liquid of filtering first collecting dose 80% is preserved in addition, carry out follow-up percolation again, continuous liquid temperature of filtering is the ethanol water of 10 DEG C ~ 15 DEG C of volumetric concentrations 85% ~ 90%, cryoconcentration become thick after to be uniformly mixed with liquid of just filtering and to make that to mix liquid of filtering for subsequent use, for subsequent use with water flushing after medicinal residues are taken out;

Step 3, medicinal residues step 2 obtained and Plumula Nelumbinis, Fructus Rosae Normalis, Herba Taraxaci, Testa Phaseoli radiati, Flos Chrysanthemi Indici, Herba Portulacae, Herba Artemisiae Annuae, Spica Prunellae add the water of total dose weight portion 2 ~ 3 times, slow fire boils 16 ~ 18 minutes, then filtering medicinal residues obtain to boil for the first time and boil liquid, add the medicamental pulverata that step 2 is obtained again, slow fire boils 10 ~ 13 minutes, adds the medicine slurry that step one is obtained after truce, and uniform stirring makes the medicament containing medicine slurry medicine meat;

Step 4, the every 250ML of medicament mono-bag that step 3 is obtained encapsulates, and the refrigerator putting into 0 ~ 6 DEG C after having encapsulated stores for future use.

The wherein pharmacological action of part medical material:

Herba Teucrii Viscidi leaf: nature and flavor acrid in the mouth; Bitter; Cool in nature.Gui Jing returns lung; Large intestine channel.Function cures mainly cooling blood for hemostasis; Removing toxic substances and promoting subsidence of swelling.Main hemoptysis; Spit blood; Epistaxis; Lung abscess; Traumatic injury; Swollen ulcer drug; Swelling and pain of hemorrhoid; Dermatitis rhus; Tinea pedis; Lyssodexis; Venom

Folium Dolichoris: the pungent sweetness of nature and flavor; Flat; Slightly poisonous.Return through spleen; Stomach; Heart channel.Function cures mainly summer heat relieving and dampness eliminating, removing toxic substances and promoting subsidence of swelling.Main heat-damp in summer is vomited and diarrhoea, furuncle toxic swelling, and snakeworm flood dragon hinders

Exocarpium Citrulli: nature and flavor sweet in the mouth; Cool in nature; Nontoxic.Return through GUIXIN; Stomach; Urinary bladder channel.Function cures mainly heat clearing away; Quench one's thirst; Diuresis.Main summer-heat excessive thirst; Oliguria; Edema; Aphtha of the mouth and tongue

Fructus Benincasae: nature and flavor sweet in the mouth; Light; Cold nature.Gui Jing returns lung; Intestine and small intestine; Urinary bladder channel.Function cures mainly diuresis; Heat clearing away; Reduce phlegm; Promote the production of body fluid; Removing toxic substances.Main edema distension; Gonorrhea; Foot gas; Phlegm dyspnea; Summer-heat is unhappy; Quench one's thirst; Carbuncle; Anal fistula; And separate borax poison; Ichthyotoxin; Alcoholism

Plumula Nelumbinis: nature and flavor are sweet is cool.Function cures mainly dissipating blood stasis for subsidence of swelling, evacuating pus and expelling toxin by reinforcing QI and blood, hemostasis.Control pulmonary abscess, sore and toxic, dermatosis, liver-heat, various hemorrhage.

Flatstiped corydalis herb: nature and flavor are cold in nature, bitter in the mouth.Function cures mainly antipyretic analgesic.Control gastritis, Peptic Ulcers, dysentery, sciatica.

QINGZHU leaf: nature and flavor are sweet; Light; Cold.Return careful; Lung; Stomach warp.Function cures mainly clearing heat and relieving fidgetness; To promote the production of body fluid diuresis.Main calentura excessive thirst; little Jing Epilepsy; Cough with dyspnea tells nosebleed; Oliguria with reddish urine; Erosion of the oral mucosa tongue boil

Herba Taraxaci: nature and flavor are bitter, sweet, cold.Gui Jing returns liver, stomach warp.Function cures mainly heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Flos Chrysanthemi Indici: nature and flavor bitter in the mouth; Pungent; Property is put down.Gui Jing returns lung; Liver Channel.Function cures mainly heat-clearing and toxic substances removing; Dispelling wind suppressing the hyperactive liver.Main furuncle; Carbuncle; Erysipelas; Eczema; Dermatitis; Anemopyretic cold; Laryngopharynx swelling and pain; Hypertension

Herba Portulacae: nature and flavor acid, cold.Gui Jing returns liver, large intestine channel.Function cures mainly heat-clearing and toxic substances removing, cooling blood for hemostasis.For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.

Talcum: nature and flavor are sweet, light, cold.Gui Jing returns bladder, lung, stomach warp.Function cures mainly inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore.For pyretic stranguria, stranguria caused by urinary stone, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea; External treatment eczema, eczema, miliaria.

Folium Luffae: nature and flavor bitter in the mouth; Cold nature.Function cures mainly heat-clearing and toxic substances removing; Hemostasis; Drive away summer heat.Main carbuncle; Furuncle swells; Skin ulcer tinea; Serpentis stings; Burn; Laryngopharynx swelling and pain; Wound hemorrhage; Summer-heat excessive thirst.

Herba Moslae: acrid in the mouth, tepor.Gui Jing attaches to the lung and stomach meridians.Function cures mainly relieving the exterior syndrome by diaphoresis, and middle dampness removing.For summer-heat damp cold, fever with aversion to cold, has a headache lossless, and stomachache is vomited and diarrhoea, dysuria.

Fructus Rosae Normalis: nature and flavor are sweet; Bitter; Cold in nature.Return through liver; Gallbladder; Kidney channel.Function cures mainly clearing and antitussive; Dampness removing jaundice eliminating; Exempt from numbness pain relieving.Main fever caused by exogenous pathogens; Cough due to lung-heat; Jaundice; Stranguria with turbid discharge; Rheumatic arthralgia; Hypertension

Ramulus Uncariae Cum Uncis: sweet in the mouth is cool.Gui Jing returns liver, pericardium channel.Function cures mainly heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.Dizzy for having a headache, dysphoric cold, infantile convulsion is twitched, pre-eclampsia; Hypertension.

Radix Rubi obcordati: nature and flavor are bitter; Flat.Return through liver; Large intestine channel.Function cures mainly relaxing muscles and tendons and activating QI and blood in the collateral, clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating.Main bones and muscles pain, limbs flaccidity softening wood, red ultrawhite dysentery, icterohepatitis, tonsillitis, innominate toxic swelling.

Owing to have employed technique scheme, Herba Teucrii Viscidi leaf, Folium Dolichoris, Exocarpium Citrulli, Fructus Benincasae, Plumula Nelumbinis, QINGZHU leaf, flatstiped corydalis herb, Fructus Rosae Normalis, Herba Taraxaci, Flos Chrysanthemi Indici, Herba Portulacae, Talcum, Folium Luffae, Herba Moslae, Herba Artemisiae Annuae, Testa Phaseoli radiati, Spica Prunellae, good functions of relieving summer heat, antithermic medical material in the present invention, fully ensure that the effect of cooling of relieving summer heat, removing heat from blood, heat of dispelling, to make in heatstroke body warm is neutralized rapidly, reaches good effect of relieving summer heat.In the inventive method, Herba Teucrii Viscidi leaf, Folium Dolichoris, Exocarpium Citrulli, Fructus Benincasae, QINGZHU leaf, Folium Luffae are put into beater and are made medicine slurry, flatstiped corydalis herb, Herba Moslae, Talcum are ground, then put into Percolation device and carry out percolation, Plumula Nelumbinis, Fructus Rosae Normalis, Herba Taraxaci, Testa Phaseoli radiati, Flos Chrysanthemi Indici, Herba Portulacae, Herba Artemisiae Annuae, Spica Prunellae boil, dissimilar medical material and act on different medical materials and separate and adopt different extraction processing methods, be conducive to fully the effective ingredient in medical material being retained, guarantee therapeutic effect.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is described further.

Embodiment

Treat a medicine for heatstroke, be made up of the raw material of following weight portion: Herba Teucrii Viscidi leaf 80g, Folium Dolichoris 80g, Exocarpium Citrulli 80g, Fructus Benincasae 70g, Plumula Nelumbinis 70g, QINGZHU leaf 70g, flatstiped corydalis herb 80g, Fructus Rosae Normalis 70g, Herba Taraxaci 70g, Flos Chrysanthemi Indici 90g, Herba Portulacae 90g, Talcum 50g, Folium Luffae 50g, Herba Moslae 50g, Herba Artemisiae Annuae 50g, Testa Phaseoli radiati 50g, Spica Prunellae 50g.

The manufacture method of the medicine of above-mentioned treatment heatstroke, comprises the following steps:

Step one, puts into beater by Herba Teucrii Viscidi leaf, Folium Dolichoris, Exocarpium Citrulli, Fructus Benincasae, QINGZHU leaf, Folium Luffae, and it is for subsequent use that medicine slurry is made in 1100r/min making beating for 5 ~ 8 minutes;

Step 2, flatstiped corydalis herb, Herba Moslae, Talcum are ground, then put into Percolation device and carry out percolation, first carry out preliminary percolation, liquid of just filtering is the ethanol water of volumetric concentration 75% ~ 80%, and the first liquid of filtering first collecting dose 80% is preserved in addition, carry out follow-up percolation again, continuous liquid temperature of filtering is the ethanol water of 10 DEG C ~ 15 DEG C of volumetric concentrations 85% ~ 90%, cryoconcentration become thick after to be uniformly mixed with liquid of just filtering and to make that to mix liquid of filtering for subsequent use, for subsequent use with water flushing after medicinal residues are taken out;

Step 3, medicinal residues step 2 obtained and Plumula Nelumbinis, Fructus Rosae Normalis, Herba Taraxaci, Testa Phaseoli radiati, Flos Chrysanthemi Indici, Herba Portulacae, Herba Artemisiae Annuae, Spica Prunellae add the water of total dose weight portion 2 ~ 3 times, slow fire boils 16 ~ 18 minutes, then filtering medicinal residues obtain to boil for the first time and boil liquid, add the medicamental pulverata that step 2 is obtained again, slow fire boils 10 ~ 13 minutes, adds the medicine slurry that step one is obtained after truce, and uniform stirring makes the medicament containing medicine slurry medicine meat;

Step 4, the every 250ML of medicament mono-bag that step 3 is obtained encapsulates, and the refrigerator putting into 0 ~ 6 DEG C after having encapsulated stores for future use.

Chinese medicine extract of the present invention is to the research of mice toxic and side effects

Test medicine: medicament of the present invention.

Be put to the test animal: KM mice, body weight 20 ~ 22g, and male and female half and half are provided by Shandong University's Experimental Animal Center.

Test method: preliminary experiment 50ml/kg administration animal all survives, and does not detect LD50, therefore carries out maximum dosage-feeding test.Separately get KM mice 40, if administration group and each 20 of matched group, male and female half and half.Point sex is raised, and after fasting 12H, administration group gave mouse stomach administration 3 times, each 50ml/kg, interval 4H in one day, matched group with method to distilled water.Mice is raised with granule, freely drinks water, room temperature 24 ~ 26 DEG C, relative humidity 60%, observes general activity situation and the survival condition of mice in two weeks after administration according to following table.

Following table is animal acute toxicity test observation table:

Observation item	Performance and symptom	Observed result
			Spontaneous activity	Increase, reduce, play, tiredly can not crouch	No abnormality seen
Muscular movement	Tremble, twitch, benumb, ataxia	No abnormality seen
			Muscular tension	Strengthen, weaken, myotonia, muscle relaxation	No abnormality seen
Reaction	Nervous, bradykinesia	No abnormality seen
			Vegetative nerve	Shed tears, sialorrhea, convex eye, diarrhoea, writhing response	No abnormality seen
Breathe	Suppression, rapid, exhaustion	No abnormality seen
			Skin color	Pale, cyanosis, hyperemia	No abnormality seen
Death time	Sudden death, slow dead	Without dead mouse
			Dead symptom	Struggle, opisthotonus, spit out white foams, bleed from nose, eyes, ears and mouth	Without dead mouse

Can show that this medicament has no side effect to mice by upper table.

Pharmaceutical procedures: above-mentioned medicament every day 3 bags, point early, middle and late takes, and one after each meal, take and first shaken up by medicament, the floccule making medicine starch Chinese medicine meat is uniformly dispersed in a medicament, and the course for the treatment of is 7 ~ 10 days.

Following table be the present embodiment medicament to 100 Different age group heatstroke patient treatment situation effect tables:

Dosing (bag)	Mild heat stroke	Moderate heatstroke (my god)	Severe heatstroke (my god)
				3 bags for each person every day	1～3	3～5	7～10

The foregoing is only the schematic detailed description of the invention of the present invention, and be not used to limit scope of the present invention.Any those skilled in the art, equivalent variations done under the prerequisite not departing from design of the present invention and principle and amendment, all should belong to the scope of protection of the invention.

Claims (3)

1. treat the medicine of heatstroke for one kind, it is characterized in that, be made up of the raw material of following weight portion: 7 ~ 9 parts, Herba Teucrii Viscidi leaf, Folium Dolichoris 7 ~ 9 parts, Exocarpium Citrulli 7 ~ 9 parts, 6 ~ 8 parts, Fructus Benincasae, Plumula Nelumbinis 6 ~ 8 parts, 6 ~ 8 parts, QINGZHU leaf, flatstiped corydalis herb 7 ~ 9 parts, Fructus Rosae Normalis 6 ~ 8 parts, Herba Taraxaci 6 ~ 8 parts, Flos Chrysanthemi Indici 8 ~ 10 parts, Herba Portulacae 8 ~ 10 parts, 4 ~ 6 parts, Talcum, Folium Luffae 4 ~ 6 parts, Herba Moslae 4 ~ 6 parts, Herba Artemisiae Annuae 4 ~ 6 parts, Testa Phaseoli radiati 4 ~ 6 parts, Spica Prunellae 4 ~ 6 parts.

2. a kind of medicine for the treatment of heatstroke as claimed in claim 1, it is characterized in that, 8 parts, Herba Teucrii Viscidi leaf, Folium Dolichoris 8 parts, Exocarpium Citrulli 8 parts, 7 parts, Fructus Benincasae, Plumula Nelumbinis 7 parts, 7 parts, QINGZHU leaf, flatstiped corydalis herb 8 parts, Fructus Rosae Normalis 7 parts, Herba Taraxaci 7 parts, Flos Chrysanthemi Indici 9 parts, Herba Portulacae 9 parts, 5 parts, Talcum, Folium Luffae 5 parts, Herba Moslae 5 parts, Herba Artemisiae Annuae 5 parts, Testa Phaseoli radiati 5 parts, Spica Prunellae 5 parts.

3. a kind of manufacture method for the treatment of the medicine of heatstroke as claimed in claim 1 or 2, is characterized in that, comprise the following steps:

Step one, puts into beater by Herba Teucrii Viscidi leaf, Folium Dolichoris, Exocarpium Citrulli, Fructus Benincasae, QINGZHU leaf, Folium Luffae, and it is for subsequent use that medicine slurry is made in 1100r/min making beating for 5 ~ 8 minutes;

Step 2, flatstiped corydalis herb, Herba Moslae, Talcum are ground, then put into Percolation device and carry out percolation, first carry out preliminary percolation, liquid of just filtering is the ethanol water of volumetric concentration 75% ~ 80%, and the first liquid of filtering first collecting dose 80% is preserved in addition, carry out follow-up percolation again, continuous liquid temperature of filtering is the ethanol water of 10 DEG C ~ 15 DEG C of volumetric concentrations 85% ~ 90%, cryoconcentration become thick after to be uniformly mixed with liquid of just filtering and to make that to mix liquid of filtering for subsequent use, for subsequent use with water flushing after medicinal residues are taken out;

Step 3, medicinal residues step 2 obtained and Plumula Nelumbinis, Fructus Rosae Normalis, Herba Taraxaci, Testa Phaseoli radiati, Flos Chrysanthemi Indici, Herba Portulacae, Herba Artemisiae Annuae, Spica Prunellae add the water of total dose weight portion 2 ~ 3 times, slow fire boils 16 ~ 18 minutes, then filtering medicinal residues obtain to boil for the first time and boil liquid, add the medicamental pulverata that step 2 is obtained again, slow fire boils 10 ~ 13 minutes, adds the medicine slurry that step one is obtained after truce, and uniform stirring makes the medicament containing medicine slurry medicine meat;

Step 4, the every 250ML of medicament mono-bag that step 3 is obtained encapsulates, and the refrigerator putting into 0 ~ 6 DEG C after having encapsulated stores for future use.