CN103656589B - Drug for treating viral myocarditis and preparation method thereof - Google Patents
Drug for treating viral myocarditis and preparation method thereof Download PDFInfo
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- CN103656589B CN103656589B CN201310679524.3A CN201310679524A CN103656589B CN 103656589 B CN103656589 B CN 103656589B CN 201310679524 A CN201310679524 A CN 201310679524A CN 103656589 B CN103656589 B CN 103656589B
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Abstract
The invention discloses a drug for treating the viral myocarditis and a preparation method thereof. The drug is mainly prepared from mother of pearl, dens draconis, fructus ligustri lucidi, rhizoma nerdostachyos, rhizoma polygonati, tanarius major, caulis polygoni multiflori, mulberry and the like at a certain weight ratio. The drug has the functions of clearing heat and promoting diuresis, and resolving toxin and dispersing swelling, is fast in viral myocarditis treatment effect, and good in curative effect, and has no side effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of viral myocarditis and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Viral myocarditis refers to the myocardium limitation that viral infection causes or diffuse acute or chronic inflammatory conditions, belongs to infectious cardiomyopathy.About there is 5% patient that myocarditis occurs in viral prevalence infection period, also can be dispersed in morbidity.Clinical manifestation weight is different.Multiple virus can cause myocarditis, wherein to cause the viral infection of intestinal and upper respiratory tract infection the most common.Its sickness rate, in increasing trend year by year, is transworld commonly encountered diseases and frequently-occurring disease.Because current Western medicine effectively cannot treat viral myocarditis, therefore there is great demand in the Chinese medicine of people to rapid, effective treatment viral myocarditis, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment viral myocarditis, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment viral myocarditis.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Concha Margaritifera, Dens Draconis, Fructus Ligustri Lucidi, Radix Et Rhizoma Nardostachyos, Rhizoma Polygonati, Lignum Dalbergiae Odoriferae, Caulis Polygoni Multiflori, Fructus Mori, Cortex Moutan, Fructus Citri Sarcodactylis, Fructus Crataegi, Caulis Perillae, Concha Ostreae, Herba Schizonepetae, Pericarpium Arecae, Radix Camelliae sinensis, Rhizoma Polygoni Cuspidati, Fructus Lycii, Corm Eleocharitis, Herba Taraxaci, Herba Ecliptae, Radix Panacis Quinquefolii, Rhizoma Zingiberis Recens, Radix Cynanchi Atrati, Rhizoma Paridis, Radix Gentianae Macrophyllae, Folium Mori, Cortex Albiziae, Folium Isatidis, Bulbus Allii Macrostemonis, Herba Glossogynes tenuifoliae, Rhizoma Phragmitis, Radix Bupleuri, Ganoderma, Fructus Arctii medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat viral myocarditis.Wherein select Concha Margaritifera to be because its nature and flavor are salty, cool, enter the heart, liver two warp, have suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, the function of hemostasis, controls dizziness, tinnitus, cardiopalmus, insomnia, and demented ， Jing Epilepsy is spitted blood, epistaxis, metrorrhagia.Select Dens Draconis to be that enter the heart, Liver Channel, have tranquillizing the mind by relieving convulsion, the function of heat clearing away and restlessness relieving, Zhi Jing Epilepsy is demented because its nature and flavor are puckery, cool, dysphoria with smothery sensation is uneasy, insomnia and dreamful sleep.Select Fructus Ligustri Lucidi to be because its property bitter but sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, the function of strong waist knee joint, controls yin asthenia generating intrinsic heat, dizzy, order flower tinnitus, soreness of the waist and knees, early whitening of beard and hair.Radix Et Rhizoma Nardostachyos is selected to be that temperature, enters spleen, stomach warp, have regulating QI to relieve pain, activating spleen and strengthening stomach, treat for stomachache, distension and fullness of the chest and abdomen because its nature and flavor are sweet, headache, hysteria, beriberi.Select Rhizoma Polygonati to be because its nature and flavor are sweet flat, enter spleen, lung, kidney channel, have invigorating the spleen and replenishing QI, profit cardiopulmonary, the function of bone and muscle strengthening, controls deficient cold and heat, pulmonary tuberculosis hemoptysis, after being ill the empty lack of appetite of body, and muscles and bones is weak, rheumatalgia, wind favus disease.Select Lignum Dalbergiae Odoriferae to be that temperature, enters liver, spleen channel, regulate the flow of vital energy because its nature and flavor are pungent, hemostasis, clots absorbing, the function of analgesic therapy, controls haematemesis, spitting of blood, and incised wound is hemorrhage, traumatic injury, and carbuncle skin ulcer swells, lumbago, skelalgia of rheumatism, heart peratodynia.Select Caulis Polygoni Multiflori to be because its property sweet and slightly bitter taste, flat, enter the heart, Liver Channel, nourish heart, calm the nerves, dredging collateral, the function of dispeling the wind, controls insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.Select Fructus Mori to be because its nature and flavor are sweet, cold, enter liver, kidney channel, have tonifying liver, kidney tonifying, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., grow the function of liquid, control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle ， Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.Selecting Fructus Citri Sarcodactylis, different name Fructus Citri Sarcodactylis, Bergamot, is that temperature, enter liver, stomach warp, regulate the flow of vital energy, the function of reducing phlegm, treats for stomachache, and coerces swollen, vomiting, dysphagic, phlegm retention cough with asthma, and can relieve the effect of alcohol because the arduous acid of its nature and flavor.Select Fructus Crataegi be because its nature and flavor acid sweet, tepor, enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function, controls meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's breast food stagnate.Select Caulis Perillae to be because its property acrid-sweet flavor, tepor, enter spleen, stomach, lung three warp, regulate the flow of vital energy, Shu Yu, pain relieving, antiabortive function, controls the stagnation of QI, dyspepsia, and chest and diaphragm painful abdominal mass is vexed, epigastric pain, and nausea is got along well.Select Concha Ostreae to be because its nature and flavor are salty and bitter, cool, enter liver, kidney channel, have yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, the function of arresting seminal emission, Zhi Jing Epilepsy, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.Herba Violae is selected to be that cold, enter the heart, Liver Channel, have clearing away heat-damp and promoting diuresis, the function of removing toxic substances and promoting subsidence of swelling, controls furuncle, carbuncle, scrofula, jaundice, dysentery because its nature and flavor are bitter, diarrhoea, conjunctival congestion, sore throat, venom.Select Herba Schizonepetae to be that temperature, enters lung, Liver Channel, deliver, dispel the wind, the function for the treatment of blood disorders because its nature and flavor are pungent, parch to black stops blooding, and cure cold heating, headache, laryngopharynx swelling and pain, apoplexy locked mouth, and spit blood, epistaxis, has blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.Pericarpium Arecae is selected to be that tepor, enters spleen, stomach, intestine and small intestine warp, have therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, the function of row water, controls gastral cavity abdomen painful abdominal mass swollen, beriberi, edema because its nature and flavor are pungent.Radix Camelliae sinensis is selected to be because its nature and flavor are bitter, flat, control heart disease, aphtha, psoriasis.Select Rhizoma Polygoni Cuspidati to be because its nature and flavor are bitter, flat, dispel the wind, dampness removing, removing blood stasis with potent drugs, the function of stimulating the menstrual flow, dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis ， lumps in the chest and abdomen, anal fistula hematochezia, injury from falling down, scalds, malignant boil tinea disease.Select Fructus Lycii to be that flat, have nourishing kidney, lung moistening, tonifying liver, the function of improving eyesight, controls hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, and cough due to consumptive disease, quenches one's thirst because its nature and flavor are sweet, lose clear.Corm Eleocharitis is selected to be because its nature and flavor are sweet, cold, enter lung, stomach warp, have heat clearing away, reduce phlegm, the function of removing food stagnancy, control epidemic febrile disease and quench one's thirst, jaundice, pyretic stranguria, mass in the abdomen, conjunctival congestion.Select Herba Taraxaci to be because its property bitter but sweet flavor, cold, enter liver, stomach warp, have heat-clearing and toxic substances removing, the function of diuresis eliminating stagnation, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Select Herba Ecliptae to be because its nature and flavor picric acid, cool, enter liver, kidney channel, have removing heat from blood, hemostasis, the kidney invigorating, the function of tonifying YIN, controls haematemesis, hemoptysis, epistaxis, and hematuria is had blood in stool, dysentery, and knife injury is hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, dysentery, pudendum pruritus due to damp pathogen.Radix Panacis Quinquefolii is selected to be that cool, enter the heart, lung, kidney three warp, useful lung yin, clear asthenic fire, the function of promoting the production of body fluid to quench thirst, control deficiency of the lung chronic cough, lose blood, dry throat and mouth, deficiency-heat is tired of tired because its property sweet and slightly bitter taste.Select Rhizoma Zingiberis Recens to be because its nature and flavor are pungent, temperature, enter lung, stomach, spleen channel, deliver, cold expelling, preventing or arresting vomiting, open the function of expectorant, cure cold wind and cold, vomiting, and phlegm retention, breathes with cough, and distension is had loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.Select Radix Cynanchi Atrati to be that cold, enter lung, stomach, kidney channel, have heat clearing away, the function of removing heat from blood, controls yin asthenia generating intrinsic heat, the scorching hot hypersomnia of rheumatism, lung-heat hemoptysis, pyrexial malaria, intermittent high fever because its nature and flavor hardship is salty, puerperal fidgets due to deficiency syncope due to excessive bleeding, pyretic stranguria, stranguria with blood, rheumatalgia, scrofula.Select Rhizoma Paridis to be because its nature and flavor toil, cold, poisonous, enter the heart, Liver Channel, have heat-clearing and toxic substances removing, antiasthmatic-antitussive, the function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., controls carbuncle, furuncle, scrofula, sore throat, chronic tracheitis, and infantile convulsion is twitched, snake bite and insect sting.Radix Gentianae Macrophyllae is selected to be because its nature and flavor toil, flat, enter liver, stomach, gallbladder meridian, have expelling wind and removing dampness, and blood relaxing muscles and tendons, the function of clearing away heat and promoting diuresis, dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, jaundice, has blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.Select Folium Mori to be because its property bitter but sweet flavor, cold, enter lung, Liver Channel, have expelling wind and clearing away heat, the function of cooling blood for improving eyesight, dispelling the wind and dampness pathogens generates heat, headache, and conjunctival congestion is thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis.Cortex Albiziae is selected to be because its nature and flavor are sweet, flat, enter the heart, Liver Channel, have resolving depression, and blood, mind calming, the function of subduing inflammation, controls irritability, melancholy insomnia, lung abscess, carbuncle, scrofula, injured bone.Folium Isatidis is selected to be because its nature and flavor are bitter, cold, enter liver, the heart, stomach warp, have heat clearing away, removing toxic substances, removing heat from blood, the function of hemostasis, controls epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Select Bulbus Allii Macrostemonis to be because its nature and flavor are worked hard, temperature, enter meridian of Hand-YANG MING, regulate the flow of vital energy, the chest stuffiness relieving, activate yang, the function of eliminating stagnation, control the thorough back of the body of obstruction of qi in the chest and cardialgia, gastral cavity painful abdominal mass is not relaxed, and retches, heavy after dysentery, furuncle.Select Herba Glossogynes tenuifoliae to be because its nature and flavor are micro-pungent, cool, have the function of clearing away heat-damp and promoting diuresis, control heatstroke and vomit and diarrhoea, dysentery, damp and hot edema, gingivitis, backache, herpes zoster.Rhizoma Phragmitis is selected to be that cold, enter lung, stomach warp, has heat clearing away, promotes the production of body fluid, relieving restlessness, and the function of preventing or arresting vomiting controls calentura excessive thirst, gastropyretic vomiting, dysphagic, regurgitation, consumptive lung disease, lung abscess, and separates Fugu ocellatus ichthyotoxin because its nature and flavor are sweet.Select Radix Bupleuri to be that cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain because its nature and flavor are bitter, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.Ganoderma lucidum seu Japonicum is selected to be because its nature and flavor are sweet, flat, control asthenia, cough, asthma, insomnia, dyspepsia.Select Fructus Arctii to be that cool, enter lung, stomach warp, have dispelling wind and heat pathogens, lung qi dispersing rash, the function of subduing swelling and detoxicating, controls cough due to pathogenic wind-heat, laryngopharynx swelling and pain because its nature and flavor are worked hard, macule is not saturating, and rubella is had an itch, carbuncle sore tumefacting virus.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight
Concha Margaritifera 8-16 cron tooth 2-6 gram of Fructus Ligustri Lucidi 8-15 gram
Radix Et Rhizoma Nardostachyos 8-18 gram of Rhizoma Polygonati 8-16 gram of Lignum Dalbergiae Odoriferae 8-18 gram
Caulis Polygoni Multiflori 12-20 gram of Fructus Mori 10-20 gram of Cortex Moutan 8-18 gram
Fructus Citri Sarcodactylis 12-35 Keshan short, bristly hair or beard 12-20 gram of Caulis Perillae 8-16 gram
Concha Ostreae 8-15 gram of Herba Schizonepetae 10-20 gram of Pericarpium Arecae 12-22 gram
Radix Camelliae sinensis 8-15 gram of Rhizoma Polygoni Cuspidati 6-12 gram of Fructus Lycii 8-28 gram
Corm Eleocharitis 8-16 gram of Herba Taraxaci 12-20 gram of Herba Ecliptae 8-16 gram
Radix Panacis Quinquefolii 2-6 gram of Rhizoma Zingiberis Recens 5-10 gram of Radix Cynanchi Atrati 4-12 gram
Rhizoma Paridis 8-16 gram of Radix Gentianae Macrophyllae 10-20 gram of Folium Mori 10-18 gram
Cortex Albiziae 8-18 gram of Folium Isatidis 10-20 gram of Bulbus Allii Macrostemonis 10-20 gram
Herba Glossogynes tenuifoliae 6-15 gram of Rhizoma Phragmitis 10-20 gram of Radix Bupleuri 10-23 gram
Ganoderma 8-15 gram of Fructus Arctii 10-20 gram
Be preferably
Concha Margaritifera 10 cron tooth 5 grams of Fructus Ligustri Lucidi 10 grams
Radix Et Rhizoma Nardostachyos 10 grams of Rhizoma Polygonatis 10 grams of Lignum Dalbergiae Odoriferae 10 grams
Caulis Polygoni Multiflori 15 grams of Fructus Moris 12 grams of Cortex Moutans 10 grams
Fructus Citri Sarcodactylis 15 Keshan short, bristly hair or beard 15 grams of Caulis Perillaes 10 grams
Concha Ostreae 10 grams of Herba Schizonepetae 12 grams of Pericarpium Arecae 15 grams
Radix Camelliae sinensis 10 grams of Rhizoma Polygoni Cuspidati 8 grams of Fructus Lycii 10 grams
Corm Eleocharitis 10 grams of Herba Taraxacis 15 grams of Herba Ecliptaes 10 grams
Radix Panacis Quinquefolii 5 grams of Rhizoma Zingiberis Recenss 8 grams of Radix Cynanchi Atratis 6 grams
12 grams, Rhizoma Paridis 10 grams of Radix Gentianae Macrophyllae 12 grams of Folium Mori
Cortex Albiziae 10 grams of Folium Isatidiss 12 grams of Bulbus Allii Macrostemonis 12 grams
Herba Glossogynes tenuifoliae 8 grams of Rhizoma Phragmitiss 15 grams of Radix Bupleuri 12 grams
Ganoderma 10 grams of Fructus Arctiis 12 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Concha Margaritifera: pick decontamination, knock fragment, sieve dedust bits;
2, Dens Draconis: outwash earth, smashes;
3, Fructus Ligustri Lucidi: pick decontamination, cleans, dries;
4, Radix Et Rhizoma Nardostachyos: Ex-all impurity, robs water speed and washes, pull out, cutting, dry;
5, Rhizoma Polygonati: clean earth, slightly profit, section, dries;
6, Lignum Dalbergiae Odoriferae: after water logging, steam to appropriateness, pound sheet or flaking, dry;
7, Caulis Polygoni Multiflori: clear water is cleaned, and slightly soak, pull out, after running through, cutting, dries;
8, Fructus Mori: wash, picks decontamination, extracts long handle, dries;
9, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;
10, Fructus Citri Sarcodactylis: pick decontamination, after water spray profit, chopping, dries;
11, Fructus Crataegi: pick clean impurity, enucleation;
12, purple Caulis Perillae: pick decontamination, after being soaked in water, runs through, and section, dries;
13, Concha Ostreae: clean, dry, pulverize use;
14, Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;
15, Pericarpium Arecae: pick clean impurity, rolloff makes soft, beats, sieve removes spare;
16, Radix Camelliae sinensis: get crude drug, removing impurity, cleans, runs through, cut sheet, dry, and sieve removes chip;
17, Rhizoma Polygoni Cuspidati: adopt after, smooth file, dries;
18, Fructus Lycii: clean impurity of winnowing with a dustpan, plucks residual stalk and the base of a fruit;
19, Corm Eleocharitis: clean, crust of pruning;
20, Herba Taraxaci: pick decontamination, clean earth, cutting, dries;
21, Herba Ecliptae: pick clean impurity, removing undesirable root, clean vexed, cutting is dried;
22, Radix Panacis Quinquefolii: former medicinal clear water spray tide, cover wet cloth, Xia Qiu moistens 2 days, and Winter-Spring moistens 3 days, takes out section, dries;
23, Rhizoma Zingiberis Recens: pick decontamination, cleans earth, and the used time cuts into slices;
24, Radix Cynanchi Atrati: pick clean impurity, removing stem Seedling, cleans, slightly soaks, run through, cutting, dry;
25, Rhizoma Paridis: autumn excavates, removing fibrous root, cleaning, drying;
26, Radix Gentianae Macrophyllae: pick decontamination, except removing LU, slightly soaks, runs through section, dry;
27, Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;
28, Cortex Albiziae: clear water soaks to be cleaned, and pulls out, is first divided into equal greatly rectangular after moistening, then stripping and slicing or shredding, dry;
29, Folium Isatidis: pick decontamination and dead leaf, cleans, slightly moistens, cutting, dry;
30, Bulbus Allii Macrostemonis: pick decontamination, sieve of winnowing with a dustpan goes whisker;
31, Herba Glossogynes tenuifoliae: get crude drug, picks decontamination, dries;
32, Rhizoma Phragmitis: pick decontamination and root, cutting, dry;
33, Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry immediately; ;
34, Ganoderma lucidum seu Japonicum: removing impurity, cleans, softens, cut sheet, and dry, sieve removes chip;
35, Fructus Arctii: pick decontamination, sieve removes spare.
Two, prepare
1, the Concha Margaritifera of described weight, Dens Draconis, Fructus Ligustri Lucidi, Radix Et Rhizoma Nardostachyos, Rhizoma Polygonati, Lignum Dalbergiae Odoriferae, Caulis Polygoni Multiflori, Fructus Mori, Cortex Moutan, Fructus Citri Sarcodactylis, Fructus Crataegi, Caulis Perillae, Concha Ostreae, Herba Schizonepetae, Pericarpium Arecae, Radix Camelliae sinensis, Rhizoma Polygoni Cuspidati, Fructus Lycii, Corm Eleocharitis, Herba Taraxaci, Herba Ecliptae, Radix Panacis Quinquefolii, Rhizoma Zingiberis Recens, Radix Cynanchi Atrati, Rhizoma Paridis, Radix Gentianae Macrophyllae, Folium Mori, Cortex Albiziae, Folium Isatidis, Bulbus Allii Macrostemonis, Herba Glossogynes tenuifoliae, Rhizoma Phragmitis, Radix Bupleuri, Ganoderma, Fructus Arctii are decocted with water twice, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor.
2, add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor.
3, merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, is divided into 4 doses to take.
Medicine of the present invention has clearing away heat-damp and promoting diuresis, regulating QI to relieve pain, the function of subduing swelling and detoxicating, is used for the treatment of viral myocarditis instant effect, good effect.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 100 examples for medical treatment.
2, diagnostic criteria
Extensive degree and the position of pathological changes are depended in Patients with Viral Myocarditis clinical manifestation, and the lighter can be asymptomatic, and heart failure, cardiogenic shock and sudden death can appear in severe one.Patient's premorbid of being everlasting has upper respiratory tract or intestinal infection history for 1 ~ 3 week, show as the symptoms such as heating, systemic pain, pharyngalgia, asthenia, nausea,vomiting,diarrhea, then there is cardiopalmus, uncomfortable in chest, chest pain or pareordia dull pain, dizziness, dyspnea, edema, even Adams-Stokes syndrome occurs; There is heart failure or cardiogenic shock in only a few patient.
3, Therapeutic Method
Selecting above-mentioned medicament, take to patient, every day 2 times, each 1 dose, 15 days is a course for the treatment of, takes three courses for the treatment of continuously.
4, efficacy assessment standard
Effective: viral myocarditis symptom is fully recovered, recover normal.
Take a turn for the better: viral myocarditis symptom alleviates, and the state of an illness progressively takes a turn for the better.
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form):
In above-mentioned treatment, by medicine therapeutic virus patients with myocarditis 100 example of the present invention, effective 89 examples of result, obvious effective rate is 89%, and take a turn for the better 3 examples, and improvement rate is 3%, and invalid 8 examples, total effective rate is 92%.
Claims (3)
1. treat a medicine for viral myocarditis, it is characterized in that: it is made up of the crude drug in following weight range:
Concha Margaritifera 8-16 cron tooth 2-6 gram of Fructus Ligustri Lucidi 8-15 gram
Radix Et Rhizoma Nardostachyos 8-18 gram of Rhizoma Polygonati 8-16 gram of Lignum Dalbergiae Odoriferae 8-18 gram
Caulis Polygoni Multiflori 12-20 gram of Fructus Mori 10-20 gram of Cortex Moutan 8-18 gram
Fructus Citri Sarcodactylis 12-35 Keshan short, bristly hair or beard 12-20 gram of Caulis Perillae 8-16 gram
Concha Ostreae 8-15 gram of Herba Schizonepetae 10-20 gram of Pericarpium Arecae 12-22 gram
Radix Camelliae sinensis 8-15 gram of Rhizoma Polygoni Cuspidati 6-12 gram of Fructus Lycii 8-28 gram
Corm Eleocharitis 8-16 gram of Herba Taraxaci 12-20 gram of Herba Ecliptae 8-16 gram
Radix Panacis Quinquefolii 2-6 gram of Rhizoma Zingiberis Recens 5-10 gram of Radix Cynanchi Atrati 4-12 gram
Rhizoma Paridis 8-16 gram of Radix Gentianae Macrophyllae 10-20 gram of Folium Mori 10-18 gram
Cortex Albiziae 8-18 gram of Folium Isatidis 10-20 gram of Bulbus Allii Macrostemonis 10-20 gram
Herba Glossogynes tenuifoliae 6-15 gram of Rhizoma Phragmitis 10-20 gram of Radix Bupleuri 10-23 gram
Ganoderma 8-15 gram of Fructus Arctii 10-20 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Concha Margaritifera 10 cron tooth 5 grams of Fructus Ligustri Lucidi 10 grams
Radix Et Rhizoma Nardostachyos 10 grams of Rhizoma Polygonatis 10 grams of Lignum Dalbergiae Odoriferae 10 grams
Caulis Polygoni Multiflori 15 grams of Fructus Moris 12 grams of Cortex Moutans 10 grams
Fructus Citri Sarcodactylis 15 Keshan short, bristly hair or beard 15 grams of Caulis Perillaes 10 grams
Concha Ostreae 10 grams of Herba Schizonepetae 12 grams of Pericarpium Arecae 15 grams
Radix Camelliae sinensis 10 grams of Rhizoma Polygoni Cuspidati 8 grams of Fructus Lycii 10 grams
Corm Eleocharitis 10 grams of Herba Taraxacis 15 grams of Herba Ecliptaes 10 grams
Radix Panacis Quinquefolii 5 grams of Rhizoma Zingiberis Recenss 8 grams of Radix Cynanchi Atratis 6 grams
12 grams, Rhizoma Paridis 10 grams of Radix Gentianae Macrophyllae 12 grams of Folium Mori
Cortex Albiziae 10 grams of Folium Isatidiss 12 grams of Bulbus Allii Macrostemonis 12 grams
Herba Glossogynes tenuifoliae 8 grams of Rhizoma Phragmitiss 15 grams of Radix Bupleuri 12 grams
Ganoderma 10 grams of Fructus Arctiis 12 grams.
3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Concha Margaritifera: pick decontamination, knock fragment, sieve dedust bits;
(2) Dens Draconis: outwash earth, smashes;
(3) Fructus Ligustri Lucidi: pick decontamination, cleans, dries;
(4) Radix Et Rhizoma Nardostachyos: Ex-all impurity, robs water speed and washes, pull out, cutting, dry;
(5) Rhizoma Polygonati: clean earth, slightly profit, section, dries;
(6) Lignum Dalbergiae Odoriferae: after water logging, steam to appropriateness, pound sheet or flaking, dry;
(7) Caulis Polygoni Multiflori: clear water is cleaned, and slightly soak, pull out, after running through, cutting, dries;
(8) Fructus Mori: wash, picks decontamination, extracts long handle, dries;
(9) Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;
(10) Fructus Citri Sarcodactylis: pick decontamination, after water spray profit, chopping, dries;
(11) Fructus Crataegi: pick clean impurity, enucleation;
(12) purple Caulis Perillae: pick decontamination, after being soaked in water, runs through, and section, dries;
(13) Concha Ostreae: clean, dry, pulverize use;
(14) Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;
(15) Pericarpium Arecae: pick clean impurity, rolloff makes soft, beats, sieve removes spare;
(16) Radix Camelliae sinensis: get crude drug, removing impurity, cleans, runs through, cut sheet, dry, and sieve removes chip;
(17) Rhizoma Polygoni Cuspidati: adopt after, smooth file, dries;
(18) Fructus Lycii: clean impurity of winnowing with a dustpan, plucks residual stalk and the base of a fruit;
(19) Corm Eleocharitis: clean, crust of pruning;
(20) Herba Taraxaci: pick decontamination, clean earth, cutting, dries;
(21) Herba Ecliptae: pick clean impurity, removing undesirable root, clean vexed, cutting is dried;
(22) Radix Panacis Quinquefolii: former medicinal clear water spray tide, cover wet cloth, Xia Qiu moistens 2 days, and Winter-Spring moistens 3 days, takes out section, dries;
(23) Rhizoma Zingiberis Recens: pick decontamination, cleans earth, and the used time cuts into slices;
(24) Radix Cynanchi Atrati: pick clean impurity, removing stem Seedling, cleans, slightly soaks, run through, cutting, dry;
(25) Rhizoma Paridis: autumn excavates, removing fibrous root, cleaning, drying;
(26) Radix Gentianae Macrophyllae: pick decontamination, except removing LU, slightly soaks, runs through section, dry;
(27) Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;
(28) Cortex Albiziae: clear water soaks to be cleaned, and pulls out, is first divided into equal greatly rectangular after moistening, then stripping and slicing or shredding, dry;
(29) Folium Isatidis: pick decontamination and dead leaf, cleans, slightly moistens, cutting, dry;
(30) Bulbus Allii Macrostemonis: pick decontamination, sieve of winnowing with a dustpan goes whisker;
(31) Herba Glossogynes tenuifoliae: get crude drug, picks decontamination, dries;
(32) Rhizoma Phragmitis: pick decontamination and root, cutting, dry;
(33) Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry immediately; ;
(34) Ganoderma lucidum seu Japonicum: removing impurity, cleans, softens, cut sheet, and dry, sieve removes chip;
(35) Fructus Arctii: pick decontamination, sieve removes spare;
(2) prepare
(1) Concha Margaritifera of described weight, Dens Draconis, Fructus Ligustri Lucidi, Radix Et Rhizoma Nardostachyos, Rhizoma Polygonati, Lignum Dalbergiae Odoriferae, Caulis Polygoni Multiflori, Fructus Mori, Cortex Moutan, Fructus Citri Sarcodactylis, Fructus Crataegi, Caulis Perillae, Concha Ostreae, Herba Schizonepetae, Pericarpium Arecae, Radix Camelliae sinensis, Rhizoma Polygoni Cuspidati, Fructus Lycii, Corm Eleocharitis, Herba Taraxaci, Herba Ecliptae, Radix Panacis Quinquefolii, Rhizoma Zingiberis Recens, Radix Cynanchi Atrati, Rhizoma Paridis, Radix Gentianae Macrophyllae, Folium Mori, Cortex Albiziae, Folium Isatidis, Bulbus Allii Macrostemonis, Herba Glossogynes tenuifoliae, Rhizoma Phragmitis, Radix Bupleuri, Ganoderma, Fructus Arctii are decocted with water twice, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor;
(2) add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor;
(3) merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, is divided into 4 doses to take.
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| CN102327549A (en) * | 2011-09-16 | 2012-01-25 | 重庆市南川区瑞丰农业开发有限责任公司 | Chinese herbal medicine for treating palpitation due to yin deficiency and liver depression induced by heart-qi deficiency |
| CN103316214A (en) * | 2013-06-19 | 2013-09-25 | 郑霞 | Chinese medicine composition for treating viral myocarditis and preparation method thereof |
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| CN102327549A (en) * | 2011-09-16 | 2012-01-25 | 重庆市南川区瑞丰农业开发有限责任公司 | Chinese herbal medicine for treating palpitation due to yin deficiency and liver depression induced by heart-qi deficiency |
| CN103316214A (en) * | 2013-06-19 | 2013-09-25 | 郑霞 | Chinese medicine composition for treating viral myocarditis and preparation method thereof |
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| Title |
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| 中医药治疗病毒性心肌炎;马有凤;《天津药学》;20030228;第15卷(第1期);60-63 * |
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