CN105191934A - Disinfectant, nonwoven fabric containing disinfectant, preparation method and application - Google Patents
Disinfectant, nonwoven fabric containing disinfectant, preparation method and application Download PDFInfo
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- CN105191934A CN105191934A CN201510570112.5A CN201510570112A CN105191934A CN 105191934 A CN105191934 A CN 105191934A CN 201510570112 A CN201510570112 A CN 201510570112A CN 105191934 A CN105191934 A CN 105191934A
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Abstract
The invention relates to disinfectant. The disinfectant comprises the following components by weight percent (according to 100 percent of total weight): 0.1 to 1 percent of quaternary ammonium salt; 0.01 to 1 percent of octoate compound; 0.01 to 1 percent of oxide alcohol oxacyclopropane epoxypropane co-polymer; 37 to 99.88 percent of water; and 0 to 60 percent of alcohol. The disinfectant has good sterilizing capacity, low corrosion to the metal, rapid drying speed after being used for scrubbing the surface of an object and good compatibility with nonwoven fabric.
Description
Technical field
The disclosure relates to cleaning and sterilization field, particularly relates to a kind of thimerosal, non-woven fabrics and its preparation method and application containing thimerosal.
Background technology
In recent years, increasing research showed, cleaning of hospital is relevant with the generation of Disinfection Effect and hospital infection event.
At present, have the body surface cleaning-sterilizing method that two kinds traditional in Chinese medical field, one uses towel to coordinate chlorine-containing agent, and another kind is the method that towel coordinates alcohol disinfectant.Above-mentioned two kinds of methods all need expensive manpower and time configure sterilised liq and clean towel, and, if the configuration of disinfectant is inaccurate or the process of towel is not thorough, all may affects Disinfection Effect, even cause cross pollution.In addition, the smell of chlorine-containing agent is large to human body excitant, and its chemical composition may cause corrosion to body surface simultaneously.Therefore, be necessary to develop a kind of new thimerosal for surface of objects in hospital by cleanness and sterilization and contain the non-woven fabrics of thimerosal.
Summary of the invention
For above-mentioned problems of the prior art, the disclosure aims to provide a kind of new thimerosal, this thimerosal should at least have good bactericidal property, shorter in the drying time of body surface, to the corrosivity of metal surface less and and nonwoven be furnished with good compatibility.
Some aspect of the present disclosure provides a kind of thimerosal, in the gross weight of described thimerosal by 100wt.%, comprising: the quaternary ammonium salt of 0.1-1wt.%; The caprylates of 0.01-1wt.%; The oxidizing alcohol SYNPERONIC PE/F68 of 0.01-1wt.%; The water of 37-99.88wt.%; With the alcohol of 0-60wt.%.
Some aspect of the present disclosure provides a kind of method preparing described thimerosal, comprises step: by each composition mixing of described thimerosal.
Some aspect of the present disclosure provides a kind of non-woven fabrics containing thimerosal, comprising: non-woven fabrics and the thimerosal according to the present disclosure be dispersed in described non-woven fabrics; Wherein, in the gross weight of described non-woven fabrics by 100wt.%, described non-woven fabrics comprises: the viscose rayon of 0-50wt.% and the polyster fibre of 50-100wt.%; The weight ratio of described thimerosal and described non-woven fabrics is 3: 1-6: 1.
Some aspect of the present disclosure provides a kind of method preparing non-woven fabrics containing thimerosal, comprise step, to be distributed in non-woven fabrics according to the thimerosal described in the disclosure, wherein, in the gross weight of described non-woven fabrics by 100wt.%, described non-woven fabrics comprises: the viscose rayon of 0-50wt.% and the polyster fibre of 50-100wt.%; The weight ratio of described thimerosal and described non-woven fabrics is 3: 1-6: 1.
Some aspect of the present disclosure provides a kind of application of non-woven fabrics in medical cleaning-sterilizing containing thimerosal according to the present disclosure.
Fast, efficiently the common germs of hospital such as Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, Candida albicans can be killed according to thimerosal of the present disclosure.Meanwhile, thimerosal of the present disclosure is very low to metal protection, and durability is strong, and after wipe surfaces, rate of drying is very fast, better with the compatibility of non-woven fabrics, is applicable to the clean of Pangquangou Natural Reserve and sterilization.
Embodiment
Should be appreciated that when not departing from the scope of the present disclosure or spirit, those skilled in the art can imagine other various embodiments according to the instruction of this specification and can modify to it.Therefore, following embodiment does not have restrictive, sense.
Except as otherwise noted, otherwise all numerals of the representation feature size, quantity and the physicochemical characteristic that use in this specification and claim be all construed as and all modified by term " about " in all cases.Therefore, unless indicated to the contrary, otherwise the numerical parameter listed in above-mentioned specification and appended claims is all approximative values, those skilled in the art can utilize instruction content disclosed herein to seek the desirable characteristics obtained, and suitably changes these approximative values.The use of the number range represented with end points comprises all numerals within the scope of this and any scope within the scope of this, and such as, 1 to 5 comprises 1,1.1,1.3,1.5,2,2.75,3,3.80,4 and 5 etc.
thimerosal
Some aspect of the present disclosure provides a kind of thimerosal, in the gross weight of described thimerosal by 100wt.%, comprising: the quaternary ammonium salt of 0.1-1wt.%; The caprylates of 0.01-1wt.%; The oxidizing alcohol SYNPERONIC PE/F68 of 0.01-1wt.%; The water of 37-99.88wt.%; With the alcohol of 0-60wt.%.
Quaternary ammonium salt
According in thimerosal of the present disclosure, described quaternary ammonium salt has good sterilization effect, to common microbiological as staphylococcus aureus, Escherichia coli, pseudomonas aeruginosa and Candida albicans all have significant killing effect.
According to some embodiment, in the gross weight of described thimerosal by 100wt.%, quaternary ammonium salt comprises: the strand quaternary ammonium salt of 0.05-0.95wt.%; (ii) double-chain quaternary ammonium salt of 0.05-0.95wt.%.
According to some embodiment, described strand quaternary ammonium salt comprises at least one composition in following group: C12-C18 zephiran, C12-C18 Alkyl dimethyl benzyl ammonium bromide, C12-C18 alkyl trimethyl benzyl ammonium chloride and C12-C18 alkyl trimethyl Benzylphosphonium Bromide ammonium.
According to some embodiment, described double-chain quaternary ammonium salt comprises at least one composition in following group: the two alkyl dimethyl ammonium bromide of C8-C18 Dialkyl dimethyl ammonium chloride, C8-C18.
According to some embodiment, described quaternary ammonium salt can select the Bardac208M purchased from Lonza company.
In the gross weight of described thimerosal by 100wt.%, the content of described quaternary ammonium salt is 0.1-1wt.%.When the content of described quaternary ammonium salt is greater than 0.1wt.%, thimerosal can be made to have good bactericidal effect; When the content of described quaternary ammonium salt is less than 1wt.%, thimerosal can not produce pungent smell, can not stimulate the respiratory tract of human body.
Caprylates
According in disclosed thimerosal, described caprylates significantly can reduce the surface tension of thimerosal, promotes the drying time after wiping, strengthens sterilizing ability.
According to some embodiment, described caprylates comprises at least one composition in following group: the smooth caprylate of sorb, the smooth oleate of sorb, the smooth stearate of sorb and sorbitan monopalmitate.
According to some embodiment, the smooth caprylate of described sorb can select the NatraSenseLF8 purchased from Croda company.
According to some embodiment, the smooth oleate of described sorb far can become create Science and Technology Ltd. purchased from Wuhan.
According to some embodiment, the smooth stearate of described sorb can purchased from daylight chemistry trade (Shanghai) Co., Ltd..
According to some embodiment, described sorbitan monopalmitate can purchased from daylight chemistry trade (Shanghai) Co., Ltd..
In the gross weight of described thimerosal by 100wt.%, the content of described caprylates is 0.01-1wt.%.When the content of described caprylates is 0.01-1wt.%, thimerosal can be made shorter in the drying time of body surface, and strengthen sterilizing ability further.
Oxidizing alcohol SYNPERONIC PE/F68
According in disclosed thimerosal, described oxidizing alcohol SYNPERONIC PE/F68 can reduce corrosion of metal, promotes bactericidal property.
According to some embodiment, the carbon number of described oxidizing alcohol SYNPERONIC PE/F68 is 12-15.
According to some embodiment, described oxidizing alcohol SYNPERONIC PE/F68 can select the GenapolEP2584 purchased from Clarient company.
In the gross weight of described thimerosal by 100wt.%, the content of described oxidizing alcohol SYNPERONIC PE/F68 is 0.01-1wt.%.When the content of described oxidizing alcohol SYNPERONIC PE/F68 is 0.01-1wt.%, the non-woven fabrics containing thimerosal can not leave too much foam after wiping across body surface.
Water
According in disclosed thimerosal, described water is the solvent in described thimerosal.
In the gross weight of described thimerosal by 100wt.%, the content of described water is 37-99.88wt.%.When the content of described water is 37-99.88wt.%, each composition in thimerosal can dissolve fully.
Alcohol
According in disclosed thimerosal, described alcohol can promote rapid draing and bactericidal effect further.
According to some embodiment, described alcohol comprises at least one composition in following group: ethanol and isopropyl alcohol.
According to some embodiment, described ethanol can purchased from Chemical Reagent Co., Ltd., Sinopharm Group.
According to some embodiment, described isopropyl alcohol can purchased from Chemical Reagent Co., Ltd., Sinopharm Group
In the gross weight of described thimerosal by 100wt.%, the content of described alcohol is 0-60wt.%.
Erosion resistant agent
According to thimerosal of the present disclosure, in the gross weight of described thimerosal by 100wt.%, the erosion resistant agent of 0.1-0.5wt.% can also be comprised.
According in thimerosal of the present disclosure, described erosion resistant agent can suppress corrosion of metal further.
According to some embodiment, described erosion resistant agent can select known those applicable erosion resistant agent.According to some embodiment, described erosion resistant agent comprises at least one composition in following group: chromate, nitrite, silicate, molybdate, tungstates, Quadrafos and zinc salt.
According to some embodiment, described chromate can select the sodium chromate purchased from Shantou, Shanghai brilliance chemical reagent Co., Ltd.
According to some embodiment, described nitrite can select the natrium nitrosum purchased from Shantou, Shanghai brilliance chemical reagent Co., Ltd.
prepare the method for thimerosal
Some aspect of the present disclosure provides a kind of method preparing thimerosal, comprises step: by each composition mixing according to thimerosal of the present disclosure.
According to some embodiment, the described method preparing thimerosal, in the gross weight of described thimerosal by 100wt.%, comprises step: the quaternary ammonium salt adding 0.1-1wt.% in the water of 5-20wt.%, to obtain the first solution; The caprylates of 0.01-1.0wt.% is added, to obtain the second solution in the first solution; In the second solution, add the alcohol of the water of 5-20wt.%, 0.01-1.0wt.% oxidizing alcohol SYNPERONIC PE/F68 and 0-60wt.%, polishing water to 100wt.%, with the liquid that is sterilized.
According to some embodiment, the described method preparing thimerosal, in the gross weight of described thimerosal by 100wt.%, comprises step: the quaternary ammonium salt adding 0.1-1wt.% in the water of 5-20wt.%, to obtain the first solution; The caprylates of 0.01-1.0wt.% is added, to obtain the second solution in the first solution; In the second solution, add the water of 5-20wt.%, 0.01-1.0wt.% oxidizing alcohol SYNPERONIC PE/F68, the alcohol of 0-60wt.% and the erosion resistant agent of 0.1-0.5wt.%, polishing water to 100wt.%, with the liquid that is sterilized.
About the introduction of each composition of described thimerosal, refer to " thimerosal " part of this specification.
containing the non-woven fabrics of thimerosal
Some aspect of the present disclosure provides a kind of non-woven fabrics containing thimerosal, comprising: non-woven fabrics and be dispersed in described non-woven fabrics according to thimerosal of the present disclosure; Wherein, in the gross weight of described non-woven fabrics by 100wt.%, described non-woven fabrics comprises: the viscose rayon of 0-50wt.% and the polyster fibre of 50-100wt.%; The weight ratio of described thimerosal and described non-woven fabrics is 3: 1-6: 1.
About the introduction of each composition of described thimerosal, refer to " thimerosal " part of this specification.
According to some embodiment, described viscose rayon can select known those applicable viscose rayons.According to some embodiment, described viscose rayon can obtain by the following method: native cellulose alkalization is obtained alkali cellulose, alkali cellulose and carbon disulphide are reacted and generates cellulose xanthate ester, again cellulose xanthate ester is dissolved in sig water and obtains viscous solution (viscose glue), this viscous solution (viscose glue) is made viscose rayon through known wet spinning and aftertreatment technology.
According to some embodiment, described polyster fibre can select known those applicable polyster fibres.According to some embodiment, described polyster fibre can obtain by the following method: by p-phthalic acid (PTA) or dimethyl terephthalate (DMT) (DMT) and ethylene glycol (EG) through esterification or ester exchange, obtain PETG (PET) by polycondensation reaction again, then make polyster fibre through known spinning and aftertreatment technology.
preparation is containing the method for the non-woven fabrics of thimerosal
Some aspect of the present disclosure provides a kind of method preparing non-woven fabrics containing thimerosal, comprise step, to be distributed in non-woven fabrics according to thimerosal of the present disclosure, wherein, in the gross weight of described non-woven fabrics by 100wt.%, described non-woven fabrics comprises: the viscose rayon of 0-50wt.% and the polyster fibre of 50-100wt.%; The weight ratio of described thimerosal and described non-woven fabrics is 3: 1-6: 1.
About the introduction of described thimerosal, refer to this specification "
thimerosal" part.
About the introduction of described non-woven fabrics, refer to this specification "
containing the non-woven fabrics of thimerosal" part.
containing the application of the non-woven fabrics of thimerosal
Some aspect of the present disclosure provides a kind of according to the application of non-woven fabrics in medical cleaning-sterilizing containing thimerosal of the present disclosure.
Can with according to the body surface in the non-woven fabrics contact hospital containing thimerosal of the present disclosure, to realize the object of cleaning-sterilizing.
Following detailed description is intended to exemplarily and in non-limiting manner the disclosure is described.
Embodiment 1 is a kind of thimerosal, in the gross weight of described thimerosal by 100wt.%, comprising: the quaternary ammonium salt of 0.1-1wt.%; The caprylates of 0.01-1wt.%; The oxidizing alcohol SYNPERONIC PE/F68 of 0.01-1wt.%; The water of 37-99.88wt.%; With the alcohol of 0-60wt.%.
Embodiment 2 is a kind of thimerosals according to embodiment 1, and wherein, in the gross weight of described thimerosal by 100wt.%, described quaternary ammonium salt comprises: the strand quaternary ammonium salt of (i) 0.05-0.95wt.%; (ii) double-chain quaternary ammonium salt of 0.05-0.95wt.%.
Embodiment 3 is a kind of thimerosals according to embodiment 2, wherein, described strand quaternary ammonium salt comprises at least one composition in following group: C12-C18 zephiran, C12-C18 Alkyl dimethyl benzyl ammonium bromide, C12-C18 alkyl trimethyl benzyl ammonium chloride and C12-C18 alkyl trimethyl Benzylphosphonium Bromide ammonium.
Embodiment 4 is a kind of thimerosals according to embodiment 2 or 3, and wherein, described double-chain quaternary ammonium salt comprises at least one composition in following group: the two alkyl dimethyl ammonium bromide of C8-C18 Dialkyl dimethyl ammonium chloride, C8-C18.
Embodiment 5 is a kind of thimerosals according to any one of embodiment 1 to 4, wherein, described caprylates comprises at least one composition in following group: the smooth caprylate of sorb, the smooth oleate of sorb, the smooth stearate of sorb and sorbitan monopalmitate.
Embodiment 6 is a kind of thimerosals according to any one of embodiment 1 to 5, and wherein, the carbon number of described oxidizing alcohol SYNPERONIC PE/F68 is 12-15.
Embodiment 7 is a kind of thimerosals according to any one of embodiment 1 to 6, and wherein, described alcohol comprises at least one composition in following group: ethanol and isopropyl alcohol.
Embodiment 8 is a kind of thimerosals according to any one of embodiment 1 to 7, and wherein, in the gross weight of described thimerosal by 100wt.%, described thimerosal also comprises the erosion resistant agent of 0.1-0.5wt.%.
Embodiment 9 is a kind of thimerosals according to embodiment 8, and wherein, described erosion resistant agent comprises at least one composition in following group: chromate, nitrite, silicate, molybdate, tungstates, Quadrafos and zinc salt.
Embodiment 10 is a kind of methods preparing thimerosal, comprises step: by each composition mixing of the thimerosal according to any one of embodiment 1-9.
Embodiment 11 is the methods according to embodiment 10, wherein, in the gross weight of described thimerosal by 100wt.%, comprises step: the quaternary ammonium salt adding 0.1-1wt.% in the water of 5-20wt.%, to obtain the first solution; The caprylates of 0.01-1.0wt.% is added, to obtain the second solution in the first solution; In the second solution, add the alcohol of the water of 5-20wt.%, 0.01-1.0wt.% oxidizing alcohol SYNPERONIC PE/F68 and 0-60wt.%, polishing water to 100wt.%, with the liquid that is sterilized.
Embodiment 12 is the methods according to embodiment 10, wherein, in the gross weight of described thimerosal by 100wt.%, comprises step: the quaternary ammonium salt adding 0.1-1wt.% in the water of 5-20wt.%, to obtain the first solution; The caprylates of 0.01-1.0wt.% is added, to obtain the second solution in the first solution; In the second solution, add the water of 5-20wt.%, 0.01-1.0wt.% oxidizing alcohol SYNPERONIC PE/F68, the alcohol of 0-60wt.% and the erosion resistant agent of 0.1-0.5wt.%, polishing water to 100wt.%, with the liquid that is sterilized.
Embodiment 13 is a kind of non-woven fabrics containing thimerosal, comprising: non-woven fabrics and the thimerosal according to any one of embodiment 1-9 be dispersed in described non-woven fabrics; Wherein, in the gross weight of described non-woven fabrics by 100wt.%, described non-woven fabrics comprises: the viscose rayon of 0-50wt.% and the polyster fibre of 50-100wt.%; The weight ratio of described thimerosal and described non-woven fabrics is 3: 1-6: 1.
Embodiment 14 is a kind of methods preparing non-woven fabrics containing thimerosal, comprise step, thimerosal according to any one of embodiment 1-9 is distributed in non-woven fabrics, wherein, in the gross weight of described non-woven fabrics by 100wt.%, described non-woven fabrics comprises: the viscose rayon of 0-50wt.% and the polyster fibre of 50-100wt.%; The weight ratio of described thimerosal and described non-woven fabrics is 3: 1-6: 1.
Embodiment 15 is a kind of non-woven fabrics application in medical cleaning-sterilizing containing thimerosal according to embodiment 13.
Embodiment
The embodiment below provided and comparative example contribute to understanding the present invention, and these embodiments and comparative example should not be construed as limitation of the present invention.Except as otherwise noted, all numbers and percentages being by weight.
The raw material adopted in embodiments of the invention and comparative example is as shown in table 1 below.
The raw material adopted in table 1 embodiment and comparative example
The preparation of thimerosal
Under the condition of normal temperature (10-25 DEG C) and normal pressure (about 1 atmospheric pressure), in the gross weight of described thimerosal by 100wt.%, each composition of thimerosal is added in glass or rustless steel container according to following steps and mixes, with the liquid that is sterilized: the quaternary ammonium salt adding 0.1-1wt.% in the water of 5-20wt.%, to obtain the first solution; The caprylates of 0.01-1.0wt.% is added, to obtain the second solution in the first solution; In the second solution, add the alcohol of the water of 5-20wt.%, 0.01-1.0wt.% oxidizing alcohol SYNPERONIC PE/F68 and 0-60wt.%, polishing water to 100wt.%, with the liquid that is sterilized.
In addition, in the gross weight of described thimerosal by 100wt.%, described first solution, as required, can also comprise the erosion resistant agent of 0.1-0.5wt.% further.
Containing the preparation of the non-woven fabrics of thimerosal
Be the ratio of 3: 1-6: 1 according to the weight ratio of thimerosal and non-woven fabrics under the condition of normal temperature (10-25 DEG C) and normal pressure (about 1 atmospheric pressure), thimerosal be distributed in non-woven fabrics, to obtain the non-woven fabrics containing thimerosal.
According to some embodiment, the mode that described thimerosal can be suitable for by sprinkling irrigation, infiltration etc. is distributed in non-woven fabrics, to obtain the non-woven fabrics containing thimerosal.
During the disclosure assesses containing thimerosal non-woven fabrics by " containing rate of drying test behind the non-woven fabrics cleaning piece surface of thimerosal ", thimerosal is in the drying capacity of body surface.
The disclosure assesses the corrosivity of thimerosal in the non-woven fabrics containing thimerosal by " erosion test ".
The disclosure assesses the bactericidal property of thimerosal in the non-woven fabrics containing thimerosal by " sterilizing ability test ".
The disclosure assesses the compatibility of non-woven fabrics and thimerosal in the non-woven fabrics containing thimerosal by " compatibility test of thimerosal and non-woven fabrics ".
Containing rate of drying test behind the non-woven fabrics cleaning piece surface of thimerosal
Be to mix at 3: 1-6: 1 by weight by thimerosal and non-woven fabrics, obtain the non-woven fabrics containing thimerosal;
Choose 30 × 30cm body surface (as glass surface, lacquer painting, frosting etc.);
By containing the non-woven fabrics of thimerosal, with S type wiping method, as above body surface wiping 1 time, need during wiping to wipe all areas of body surface, do not repeat wiping.Visually observe, and record the wiping of body surface all areas complete time time t
1with surface without time t during visible liquid
2; (note: estimate when surface is without visible liquid, namely judge wipe surfaces bone dry.)
Calculate t drying time, t=t
2-t
1;
If t drying time is less than 180 seconds, then represent institute survey contain thimerosal non-woven fabrics cleaning piece surface after drying capacity qualified.
Erosion test
With reference to the requirement of " disinfection technology standard-2002 " that ministry of Health of China is write, carry out erosion test:
(1) sheet metal (stainless steel substrates, iron plate, copper sheet, aluminium flake, stainless steel substrates) of cleaning is carried out surface finish, and use isopropyl alcohol wipe down.Claim 3 times after balance back to zero, using its mean value as the rear weight of test.
(2) coupon is by plastics linear system with label, numbers and dates, hanging in thimerosal.Disposable immersion 72h.Often kind of metal tests placement 3 prints at every turn.
(3) after being dipped into the stipulated time, taking out sheet metal, first use tap water, then remove corrosion product with hairbrush or other soft utensil.The corrosion product do not fallen as still having removing, remove by following method:
Copper sheet: be at room temperature soaked in 1min ~ 3min in hydrochloric acid solution (to 1000ml, hydrochloric acid proportion is 1.19 to 500ml36% ~ 38% hydrochloric acid adding distil water).
Carbon steel coupon: put in the sodium hydroxide solution of zincilate 200g/L, boil 5min ~ 30min.
Aluminium flake: (chromium trioxide 20g, phosphoric acid 500ml, adding distil water is to 1000ml to be soaked in chromium trioxide phosphoric acid solution.Phosphoric acid proportion is 1.69) in, be warming up to 80 DEG C, continue 5min ~ 10min.As clean in also do not removed, 1min in nitric acid (proportion 1.42) solution can be dipped in room temperature.
Stainless steel: be soaked in 60 DEG C of salpeter solutions (66% ~ 68% nitric acid 100ml adding distil water is to 1000ml) 20min.Or be dipped in 10min ~ 60min in 70 DEG C of ammonium citrate solutions (ammonium citrate 150g adding distil water is to 1000ml).
(4), after coupon removing corrosion product also cleans, use coarse filter paper suck dry moisture, be placed in the plate being lined with filter paper, put into 50 DEG C of incubators, dry 1h, use tweezers gripping, be down to after room temperature until its temperature and weigh on balance respectively.Claim 3 times after balance back to zero, using its mean value as the rear weight of test.When weighing, identical with before test, should cleaning gloves be worn, directly not contact print (lower same) with hand.
(5) print is when removing erosion with chemical method, and corresponding blank need be established with correction error.Blank print is same with experimental group print carries out surface treatment, clean and weigh, but soaks without disinfectant.Carry out chemical treatment, water rinsing, drying in company with experimental group print same procedure, weigh afterwards, and calculate its average weightless value.
(6) result of the test, observing and changes with record sheet metal color, and express with rate of metal corrosion (R) mean value, should deduct the weightlessness value of blank group print when calculating.Computing formula is as follows
[R is corrosion rate, mm/a (millimeter/year); M is sheet metal weight before test, g; m
tfor testing rear sheet metal weight, g; m
kfor corrosion product print weightlessness value is removed in chemical treatment, g, does not carry out chemical scavenging processor in test, leaves out m during calculating in formula
kvalue; S is the surface area total value of sheet metal, cm
2; T is test period, h; D is metal material density, kg/m
3].
Corrosivity grade scale:
| Corrosion rate R (mm/a) | Rank |
| ＜0.0100 | No corrosion |
| 0.0100～＜0.100 | Mild corrosion |
| 0.100～＜1.00 | Moderate corrosion |
| ≥1.00 | Severe is corroded |
Sterilizing ability is tested
With reference to " Disposable Sanitary Accessory sanitary standard ", appendix C sterilizing ability method of testing:
(1) test organisms 24h slant culture PBS is washed down, make bacteria suspension (concentration of requirement is: drip on contrast print with 100 μ L, bacterial count recovered is 1 × 104 ~ 9 × 104cfu/ sheet).Get by coupons (2.0cm × 3.0cm) and each 4 of contrast print (with sample homogeneous material, equal size, but not containing anti-biotic material, and through sterilization treatment), be divided into 4 groups and be placed in 4 sterilizing plates.
(2) above-mentioned bacteria suspension is got, 100 μ L are dripped by coupons and contrast print respectively each, even spread, start timing, effect 2, 5, 10, 20min, respectively print is dropped into containing the corresponding neutralizer of 5mL in vitro with aseptic tweezer, abundant mixing, do suitably dilution, then wherein 2 ~ 3 dilution factors are got, draw 0.5mL respectively and be placed in two plates, pour into cool nutrient agar (bacterium) to 40 ~ 45 DEG C or sabouraud's agar (saccharomycete) 15mL, rotate plate, make it full and uniform, after agar solidification, upset is dull and stereotyped, cultivate 48h (bacterium) or 72h (saccharomycete) for 35 DEG C ± 2 DEG C, do viable bacteria colony counting.
Test repetition 3 times, calculates sterilizing rate by formula (C1):
X3＝(A-B)/A×100％——(C1)
In formula: X3---sterilizing rate, %;
A---control sample average colony number;
B---tested sample average clump count.
When sterilizing rate >=99.999%, killing bacteria effect is excellent; As 99.9%≤sterilizing rate < 99.999%, killing bacteria effect is good; As sterilizing rate < 99.9%, killing bacteria effect is defective.
The compatibility test of thimerosal and non-woven fabrics
1. by disinfectant and non-woven fabrics according to 3: 1-6: 1 weight mix, place 1 week after mixing.
Extruded from non-woven fabrics by disinfectant after 2.1 weeks, quaternary ammonium salt content in liquid is extruded in test.
Quaternary ammonium salt content test method is as follows:
1) precision takes sample and is about 10g (record numerical value, keep after decimal point 4), as conical flask (250ml).
2) get 10ml distilled water and wash away wall of cup, add 40ml distilled water.
3) 1ml1mol/l sodium hydroxide is added.
4) 0.4ml bromophenol blue is added with liquid-transfering gun.Measure 10ml chloroform, add rotor (large size), stir.
5) tetraphenylboron sodium titer is proceeded to 50ml buret, note carrying out rinse.
6) record primary data, drip while shake up.Need shake by strong oscillating close to during terminal.
7) treat that last time becomes lavender, the blueness of lower floor's chloroform layer disappears, record tetraphenylboron sodium titrating solution consumption V.Repeat survey 3 times, the mean value getting 3 times is calculated as follows:
W％＝C×V×0.342/M×100％，
Wherein,
W is quaternary ammonium salt release rate from non-woven fabrics;
C is tetraphenylboron sodium concentration;
V is tetraphenylboron sodium consumption;
M is the weight of the quaternary ammonium salt taken.
When W >=60%, the compatibility of thimerosal and non-woven fabrics as well; As W < 60%, the compatibility of thimerosal and non-woven fabrics is bad.
Embodiment 1-5 and comparative example 1-10
Composition respectively listed by table 2a, table 2b and table 2c and consumption thereof, prepare thimerosal and the non-woven fabrics containing thimerosal according to method mentioned above.
" containing rate of drying test behind the non-woven fabrics cleaning piece surface of thimerosal ", " erosion test " " sterilizing ability test " and " compatibility test of thimerosal and non-woven fabrics " is carried out respectively according to method mentioned above." containing rate of drying test behind the non-woven fabrics cleaning piece surface of thimerosal " the results are shown in table 3; " erosion test " the results are shown in table 4a, 4b and 4c; " sterilizing ability test " the results are shown in table 5; " compatibility test of thimerosal and non-woven fabrics " the results are shown in table 6.
Table 2a
Table 2b
Table 2c
Table 3 is containing drying time behind the non-woven fabrics cleaning piece surface of thimerosal
| Sample | T drying time (second) |
| Embodiment 1 | 86 |
| Embodiment 2 | 120 |
| Embodiment 3 | 160 |
| Comparative example 1 | 230 |
| Comparative example 2 | 100 |
| Comparative example 3 | 350 |
| Comparative example 4 | 320 |
| Comparative example 5 | 215 |
| Comparative example 6 | 260 |
| Comparative example 7 | 94 |
| Comparative example 8 | 156 |
According to table 2a, table 2b, table 2c and table 3:
What embodiment 1-3 provided contains in the non-woven fabrics of thimerosal, appropriate quaternary ammonium salt, caprylates and oxidizing alcohol SYNPERONIC PE/F68 is comprised in its thimerosal, therefore behind non-woven fabrics cleaning piece surface, drying time is short, has good drying capacity.
What comparative example 1 provided contains in the non-woven fabrics of thimerosal, and its thimerosal does not comprise appropriate caprylates, and therefore, behind non-woven fabrics cleaning piece surface, drying time is longer, and drying capacity is defective.
What comparative example 3 provided contains in the non-woven fabrics of thimerosal, and its thimerosal does not comprise appropriate caprylates, and therefore, behind non-woven fabrics cleaning piece surface, drying time is longer, and drying capacity is defective.
What comparative example 4 provided contains in the non-woven fabrics of thimerosal, and its thimerosal does not comprise appropriate caprylates, and therefore, behind non-woven fabrics cleaning piece surface, drying time is longer, and drying capacity is defective.
What comparative example 5 provided contains in the non-woven fabrics of thimerosal, and its thimerosal does not comprise appropriate caprylates, and therefore, behind non-woven fabrics cleaning piece surface, drying time is longer, and drying capacity is defective.
What comparative example 6 provided contains in the non-woven fabrics of thimerosal, and its thimerosal does not comprise appropriate caprylates, and therefore, behind non-woven fabrics cleaning piece surface, drying time is longer, and drying capacity is defective.
Table 4a
Table 4b
Table 4c
According to table 2a, table 2b, table 2c, table 4a, table 4b and table 4c:
What embodiment 1-3 provided contains in the non-woven fabrics of thimerosal, appropriate quaternary ammonium salt, caprylates and oxidizing alcohol SYNPERONIC PE/F68 is comprised in its thimerosal, therefore, its non-woven fabrics not easily causes corrosion to body surface (particularly metal surface).
What comparative example 1 provided contains in the non-woven fabrics of thimerosal, and its thimerosal does not comprise appropriate oxidizing alcohol SYNPERONIC PE/F68, therefore, has moderate corrosion to copper and iron.
What comparative example 7 provided contains in the non-woven fabrics of thimerosal, and its thimerosal does not comprise appropriate oxidizing alcohol SYNPERONIC PE/F68, therefore, has moderate corrosion to copper and iron.
What comparative example 8 provided contains in the non-woven fabrics of thimerosal, and its thimerosal does not comprise appropriate oxidizing alcohol SYNPERONIC PE/F68, therefore, has moderate corrosion to copper and iron.
Table 5
According to table 2a, table 2b, table 2c, table 5:
What embodiment 1-3 provided contains in the non-woven fabrics of thimerosal, appropriate quaternary ammonium salt, caprylates and oxidizing alcohol SYNPERONIC PE/F68 is comprised in its thimerosal, therefore, the thimerosal be dispersed in non-woven fabrics all has good anti-microbial property to Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and Candida albicans.
What comparative example 1 provided contains in the non-woven fabrics of thimerosal, and its thimerosal does not comprise appropriate caprylates and oxidizing alcohol SYNPERONIC PE/F68, therefore, is dispersed in the thimerosal in non-woven fabrics not enough to the anti-microbial property of Candida albicans.
Comparative example 2, comparative example 7, and comparative example 8 provide containing in the non-woven fabrics of thimerosal, its thimerosal does not comprise appropriate oxidizing alcohol SYNPERONIC PE/F68, therefore, is dispersed in the thimerosal in non-woven fabrics not enough to the anti-microbial property of Candida albicans.
Table 6
| Sample | Quaternary ammonium salt is release rate W from non-woven fabrics |
| Embodiment 1 | 75％ |
| Embodiment 4 | 90％ |
| Embodiment 5 | 60％ |
| Comparative example 9 | 47％ |
| Comparative example 10 | 25％ |
According to table 2a, table 2b, table 2c, table 6:
What embodiment 1,4 and 5 provided contains in the non-woven fabrics of thimerosal, its non-woven fabrics comprises appropriate viscose rayon and polyster fibre, its thimerosal comprises appropriate quaternary ammonium salt, caprylates and oxidizing alcohol SYNPERONIC PE/F68, quaternary ammonium salt is more than or equal to 60% from the release rate non-woven fabrics, therefore, the compatibility of thimerosal and non-woven fabrics is good.
What comparative example 9 provided contains in the non-woven fabrics of thimerosal, and in its non-woven fabrics, the content of polyster fibre is less than 50%, and quaternary ammonium salt is less than 60% from the release rate non-woven fabrics, and therefore, the compatibility of thimerosal and non-woven fabrics is bad.
What comparative example 10 provided contains in the non-woven fabrics of thimerosal, and not containing polyster fibre in its non-woven fabrics, quaternary ammonium salt is less than 60% from the release rate non-woven fabrics, and therefore, the compatibility of thimerosal and non-woven fabrics is bad.
In sum, appropriate quaternary ammonium salt, caprylates and oxidizing alcohol SYNPERONIC PE/F68 is comprised according to thimerosal of the present disclosure, therefore this thimerosal has good compatibility with the non-woven fabrics comprising appropriate viscose rayon and polyster fibre, this thimerosal be dispersed in this non-woven fabrics not only has good bactericidal property, and shorter in the drying time of body surface, less to the corrosivity of metal surface.
Although for illustrational object, above-mentioned embodiment comprises many details, and those of ordinary skill in the art should be understood that many modification of these details, change, substitute and change all in the scope of the invention that claim is protected.Therefore, the present invention that the disclosure described in embodiment is not protected claim applies any restriction.Proper range of the present invention should be limited by claims and suitable legal equivalents thereof.The bibliography of all references is incorporated herein all by reference in full.
Claims (14)
1. a thimerosal, in the gross weight of described thimerosal by 100wt.%, comprising:
The quaternary ammonium salt of 0.1-1wt.%;
The caprylates of 0.01-1wt.%;
The oxidizing alcohol SYNPERONIC PE/F68 of 0.01-1wt.%;
The water of 37-99.88wt.%; With
The alcohol of 0-60wt.%.
2. thimerosal according to claim 1, wherein, in the gross weight of described thimerosal by 100wt.%, described quaternary ammonium salt comprises:
The strand quaternary ammonium salt of (i) 0.05-0.95wt.%; With
(ii) double-chain quaternary ammonium salt of 0.05-0.95wt.%.
3. thimerosal according to claim 2, wherein, described strand quaternary ammonium salt comprises at least one composition in following group: C12-C18 zephiran, C12-C18 Alkyl dimethyl benzyl ammonium bromide, C12-C18 alkyl trimethyl benzyl ammonium chloride and C12-C18 alkyl trimethyl Benzylphosphonium Bromide ammonium.
4. thimerosal according to claim 2, wherein, described double-chain quaternary ammonium salt comprises at least one composition in following group: the two alkyl dimethyl ammonium bromide of C8-C18 Dialkyl dimethyl ammonium chloride, C8-C18.
5. thimerosal according to claim 1, wherein, described caprylates comprises at least one composition in following group: the smooth caprylate of sorb, the smooth oleate of sorb, the smooth stearate of sorb and sorbitan monopalmitate.
6. thimerosal according to claim 1, wherein, the carbon number of described oxidizing alcohol SYNPERONIC PE/F68 is 12-15.
7. thimerosal according to claim 1, wherein, described alcohol comprises at least one composition in following group: ethanol and isopropyl alcohol.
8. thimerosal according to claim 1, wherein, in the gross weight of described thimerosal by 100wt.%, described thimerosal also comprises the erosion resistant agent of 0.1-0.5wt.%.
9. thimerosal according to claim 8, wherein, described erosion resistant agent comprises at least one composition in following group: chromate, nitrite, silicate, molybdate, tungstates, Quadrafos and zinc salt.
10. prepare a method for thimerosal, comprise step: by each composition mixing of the thimerosal according to any one of claim 1-9.
11. methods according to claim 10, wherein, in the gross weight of described thimerosal by 100wt.%, comprise step:
The quaternary ammonium salt of 0.1-1wt.% is added, to obtain the first solution in the water of 5-20wt.%;
The caprylates of 0.01-1.0wt.% is added, to obtain the second solution in the first solution;
In the second solution, add the alcohol of the water of 5-20wt.%, 0.01-1.0wt.% oxidizing alcohol SYNPERONIC PE/F68 and 0-60wt.%, polishing water to 100wt.%, with the liquid that is sterilized.
12. 1 kinds, containing the non-woven fabrics of thimerosal, comprising: non-woven fabrics and the thimerosal according to any one of claim 1-9 be dispersed in described non-woven fabrics;
Wherein,
In the gross weight of described non-woven fabrics by 100wt.%, described non-woven fabrics comprises: the viscose rayon of 0-50wt.% and the polyster fibre of 50-100wt.%;
The weight ratio of described thimerosal and described non-woven fabrics is 3: 1-6: 1.
13. 1 kinds of methods preparing the non-woven fabrics containing thimerosal, comprise step, thimerosal according to any one of claim 1-9 is distributed in non-woven fabrics, wherein, in the gross weight of described non-woven fabrics by 100wt.%, described non-woven fabrics comprises: the viscose rayon of 0-50wt.% and the polyster fibre of 50-100wt.%; The weight ratio of described thimerosal and described non-woven fabrics is 3: 1-6: 1.
14. 1 kinds of non-woven fabrics application in medical cleaning-sterilizing containing thimerosal according to claim 12.
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| CN111693521A (en) * | 2020-05-15 | 2020-09-22 | 杭州临安咔咔玛科技有限公司 | Visual color development method of non-woven fabric with antimicrobial function |
| CN112779774A (en) * | 2021-01-28 | 2021-05-11 | 中科鼎晟科技有限公司 | Broad-spectrum antibacterial non-woven fabric and preparation method and application thereof |
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| EP2060622A1 (en) * | 2007-11-13 | 2009-05-20 | The Procter & Gamble Company | Composition for cleaning hard surface |
| CN101461361A (en) * | 2007-12-18 | 2009-06-24 | 李萍 | Technique for preparing compound disinfecting liquid |
| CN101492632A (en) * | 2009-03-02 | 2009-07-29 | 上海九誉生物科技有限公司 | Composite disinfection detergent |
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| CN111693521A (en) * | 2020-05-15 | 2020-09-22 | 杭州临安咔咔玛科技有限公司 | Visual color development method of non-woven fabric with antimicrobial function |
| CN112779774A (en) * | 2021-01-28 | 2021-05-11 | 中科鼎晟科技有限公司 | Broad-spectrum antibacterial non-woven fabric and preparation method and application thereof |
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