CN105168729A

CN105168729A - Traditional Chinese medicine composition for treating dampness-heat stagnation type dysmenorrhea

Info

Publication number: CN105168729A
Application number: CN201510412604.1A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Shen Da New And High Technology Development Corp Ltd
Current assignee: Qingdao Shen Da New And High Technology Development Corp Ltd
Priority date: 2014-11-27
Filing date: 2015-07-14
Publication date: 2015-12-23
Also published as: CN105031135A

Abstract

The present invention provides a traditional Chinese medicine composition for treating dampness-heat stagnation type dysmenorrheal, wherein various raw materials of the oral preparation comprise thlaspi arvense linn, scutellaria baicalensis georgi, cortex fraxini, angelica, leonurus japonicus houtt, faeces trogopterpri, milkvetch root, taxillus sutchuenensis (lecomte) danser, tree peony bark, eupatorium fortunei, rubus chingii, myrrha, daemonorops draco, cape jasmine, radix paeoniae rubra, campsis grandiflora, cyperus rotundus l, rhizoma corydalis, salvia miltiorrhiza, ligusticum chuanxiong hort, caulis spatholobi and semen persicae, and the raw materials of the external application preparation comprise thlaspi arvense linn, sophora flavescens ait, scutellaria baicalensis georgi, dipsacales, cape jasmine, salvia miltiorrhiza, radix linderae, folium isatidis, indigo naturalis, folium artemisiae argyi and safflower. According to the present invention, the traditional Chinese medicine composition provides a two-way adjustment effect on uterus, wherein the traditional Chinese medicine composition causes excitation-contraction of the uterus in the normal state, and causes release and cycle improving when the uterus in the spasm state, such that the cell immune function is enhanced, the endometrium shedding and repair can be achieved, the period, the amount, the color and the quality of menstruation are easily restored, and purposes of the disease treatment and the root cause knowing of the clinical dysmenorrhea treatment can be achieved.

Description

A kind ofly treat Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea and preparation method thereof

Technical field

The present invention relates to the medicine configuration product containing deriving from plant composition, particularly a kind ofly treating Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea and preparation method thereof.

Background technology

Motherland's medical science is thought, women is on the occasion of menstrual period or before and after row, occur that periodically lower abdomen pain or pain draw the waist bones of the body, and even the severe pain person of fainting, is called dysmenorrhea, also known as " abdominal pain during menstruation ".Dysmenorrhea sees the earliest " golden plaque outline * the miscellaneous internal diseases in woman arteries and veins is demonstrate,proved and controls ".The Ming Dynasty's " Jing Yue's complete work * married woman rule " institute's cloud: abdominal pain during menstruation, card has deficiency and excess, real person or stagnant because trembling with fear, or because of stasis, or because of heat stagnation; Void person or because of blood deficiency, or because of the deficiency of vital energy, but the many pains of real pain person are before not row, certainly subtract through logical and pain; The many pains of empty pain person are after both row, and blood goes and pain is not stopped, or blood go and pain benefit very, mostly can by can the person of rubbing be empty, it is in fact that tenderness refuses the person of rubbing.

" all source of disease marquis opinions " " menstrual abdominalgia is waited, and thinks and married woman's menstrual abdominalgia person is subject to air-cooled gas visitor in collaterals of the uterus by impairment caused by overstrain QI and blood so that body void, the arteries and veins that damage punching is appointed ", the etiology and pathogenesis for research dysmenorrhea is established and has been found theoretical basis.

Namely "Fu Qingzhu works on obstetric" has " cold-damp be pathogen also, the arteries and veins that married woman has punching to appoint occupy the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, through water by two through and go out, and cold-damp full two through and civil strike, two disaccord and make pain " discussion." Jing Yue's complete work * married woman rule " if point out cold stagnant in warp, or because of exogenous cold institute inverse, or generally accidentally cold and cool, cause condensation not all right, stay and gather for pain." disease of married woman, because void, accumulation of pathogenic cold, stagnation of QI, void are that asthenia of qi and blood is few, accumulation of pathogenic cold is that cold-evil is condensed, and stagnation of QI is mechanism of qi pent-up.QI and blood need fill, and blood vessels are expensive unobstructed, and mechanism of qi should be adjusted and reach.Deficiency of qi and blood, insufficiency of blood is difficult to walk, and becomes addiction, qi as the commander of blood, and the stagnation of QI is not transported blood and then become addiction; Blood must be trembled with fear, and stagnates into addiction, and addiction blood blocks then functional activity of QI being not smooth, and then addiction blood is more very for the stagnation of QI." female section authentic " cloud: " married woman's moon water in the future, and first abdomen lumbago person, be stasis and QI rising in reverse order is obstructed also ".

In a word, the generation of dysmenorrhea often hindered by feelings will, and daily life is careless, or six climate exopathogens cause harm, or congenital examining composes the factors such as not enough, causes that punching is appointed, uterus QI-blood circulation is smooth, because of obstructed and pain; Or cause punching and appoint a uterus to lose in moistening foster, because of not flourish and pain, and with pass through before and after rush times.The change of uterus QI and blood is closely related, and sick position is in uterus, and punching is appointed, and with stagnation of QI and blood may bring about pain, Rong Ze pain, is not main pathogenesis.

The performance of damp and hot addiction resistance: ferritic retention of damp-heat in the interior, or damp and hot heresy is experienced in menstrual period, health preserving in puerperal accidentally, and fight mutually with blood, multiple abscess punching is appointed, pent up in palace, QI and blood is lost smooth, premenstrual, QI and blood bet in menstrual period, uterus, punching appoint QI and blood Kui very stagnant, and stagnation of QI and blood may bring about pain, causes abdominal pain during menstruation.

Over nearly twenty or thirty year, many scholars are theoretical according to the etiology and pathogenesis of the relevant dysmenorrhea of Gynecology of Chinese Medicine, in conjunction with doctor trained in Western medicine gynecology, dysmenorrhea etiology and pathology is familiar with, start with from clinical and experimental study, solve curative effect and the mechanism of Chinese medicine dysmenorrhea, all there is periodically lower abdomen pain women on the occasion of menstrual period or before and after passing through in the research ancient Chinese medicine doctor that shows to invigorate blood circulation, or pain draws waist sacrum, very then severe pain is fainted, and is called dysmenorrhea.Ancient Chinese medicine is without the record of " endometriosis " and " adenomyosis ".

Show as that enclosed mass in abdomen is tangible to be levied, abdominal pain during menstruation, the symptoms such as menoxenia, with the category belonging to the traditional Chinese medical science " addiction abdominal mass ", " dysmenorrhea ", " loss of fecundity " and " menoxenia ".Think that its main pathogenesis is for " most report thinks that dysmenorrhea is common has qi depression to blood stasis, cold blood stasis, dampness and heat stasis, deficiency of both QI and blood regulating liver-QI to suffer from a deficiency of the kidney damage five pattern of syndrome for stagnation of QI and blood may bring about pain, ' not Rong Ze pain ".

Dysmenorrhea is one of modal disease of gynecological, and its incidence rate report differs, and account for 42% ~ 90%, wherein severe pain is through accounting for 18%, nausea and vomiting can be accompanied, dripping cold sweat, deadly cold hand and foot time serious, very then faint, affect life and work more, unfavorable to the physical and mental health of women; But the treatment to dysmenorrhea, there is no desirable Therapeutic Method, western medical treatment, mainly to reduce prostaglandin in menstrual blood and symptomatic treatment, by using prostaglandin enzyme inhibitor, reduces prostaglandin (Prostaglandin, PG) generation, prevented strong or spastic uterine contraction, thus alleviate or eliminate pain, but its curative effect can not be lasting, thoroughly can not cure dysmenorrhea, and there is obvious drug side effect problem.The traditional Chinese medical science is controlled by integral syndrome differentiation opinion and is started with, and treatment dysmenorrhea demonstrates obvious advantage, has broad prospects.

Summary of the invention

Technical problem to be solved by this invention is, dysmenorrhea is a disease that is long-term, easily recurrent exerbation, can accompany nausea and vomiting, dripping cold sweat, deadly cold hand and foot, very then faint, affect life and work more time serious, totally unfavorable to the physical and mental health of women.In treatment, the appearance of PGSI, the sickness rate of this disease is greatly reduced, ibuprofen modified release capsule has stronger antiinflammatory, pain relieving, refrigeration function, by suppressing prostaglandin synthetase, thus suppresses the synthesis of prostaglandin, produce anti-inflammatory analgesic effect, therefore ibuprofen modified release capsule is premenstruum, and use has the effect prevented irritation, using menstrual period has spasmolytic, analgesic activity, is characterized in that administration is easy, instant effect.But because its symptom mainly for its pain is eased pain, improve not good to simultaneous phenomenon, thoroughly can not cure dysmenorrhea, and because of side effect larger, can cause nausea, vomit, the gastrointestinal upset such as diarrhoea, also can cause stomatitis, dizziness, tinnitus, blurred vision, the untoward reaction such as erythra, therefore still can not think that oral ibuprofen slow releasing capsule is the Perfected process for the treatment of dysmenorrhea.Chinese medicine is started with by entirety, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs demonstrates obvious advantage.For the addiction disorders of blood machine of dysmenorrhea, endocrine disturbance is main pathogeny, in conjunction with the modern pharmacological research achievement of Chinese medicine, explores traditional Chinese medical herbal treatment dysmenorrhea and has vast potential for future development.

For solving above-mentioned technical barrier, the invention provides a kind of Chinese medicine composition for the treatment of damp and hot addiction resistance type dysmenorrhea, in Chinese medicine composition described in it, oral preparations comprises the crude drug of following parts by weight: Herba Patriniae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Cortex Fraxini 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, in described Chinese medicine composition, external preparation comprises the crude drug of following parts by weight: Radix Sophorae Flavescentis 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Indigo Naturalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, the Radix Linderae 10 ~ 20 parts, Folium Isatidis 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami.

The Chinese medicine composition of described treatment damp and hot addiction resistance type dysmenorrhea, in Chinese medicine composition described in it, oral preparations can comprise the crude drug of following parts by weight: Herba Patriniae 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Cortex Fraxini 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Oletum Trogopterori 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Herba Eupatorii 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, in described Chinese medicine composition, external preparation can comprise the crude drug of following parts by weight: Radix Sophorae Flavescentis 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Radix Dipsaci 10 ~ 15 parts, Indigo Naturalis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, the Radix Linderae 10 ~ 20 parts, Folium Isatidis 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami.

The Chinese medicine composition of described treatment damp and hot addiction resistance type dysmenorrhea, in Chinese medicine composition described in it, oral preparations can also comprise the crude drug of following parts by weight: Herba Patriniae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Cortex Fraxini 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Myrrha 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Flos Campsis 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, 10 ~ 15 parts, Semen Persicae, in described Chinese medicine composition, external preparation can also comprise the crude drug of following parts by weight: Radix Sophorae Flavescentis 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Indigo Naturalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, the Radix Linderae 10 ~ 15 parts, Folium Isatidis 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Folium Artemisiae Argyi 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami.

The Chinese medicine composition of described treatment damp and hot addiction resistance type dysmenorrhea, in described Chinese medicine composition described in it, oral preparations dosage form can be: sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, plaster or syrup; In described Chinese medicine composition, external preparation formulation can be: hot compress agent, suppository and enema.

For solving the problems of the technologies described above, the invention provides a kind of preparation method for the treatment of the Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea, when in Chinese medicine composition described in it, the dosage form of oral preparations is oral liquid, preparation process comprises:

A, get all crude drug and put into water and soak, heat is extracted 2 times, is component 1;

B, by above-mentioned steps extract medicinal residues add ethanol extraction 2 times, be component 2;

C, by 2-in-1 and concentrated to component 1 and component; After adding Mel mediation, ultraviolet sterilization is canned.

In described step a, can get all crude drug and steep in water, soak more than 2 hours, add the water extraction 2 times of 8 times amount of crude drug gross weight, 6 times amount respectively, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.

In described step b, the medicinal residues of crude drug said extracted can crossed add ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, extractum is added the extraction into ethyl acetate secondary accounting for its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.

In described step c, can by above-mentioned two kinds extract extractum merge, when concentrating under reduced pressure relative density is 80 DEG C 1.35 extractum, reclaim ethanol, inserted in economic benefits and social benefits vacuum concentrator by above-mentioned two kinds of extracting solution, when being concentrated into 90 DEG C, relative density is the extractum of 1.60, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again and is condensed into extractum, and after adding Mel mediation, ultraviolet sterilization is canned.

For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method for the treatment of the Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea, and when the external preparation of Chinese medicine composition described in it is suppository, preparation process is:

By described crude drug except Folium Artemisiae Argyi, Folium Isatidis and the Radix Linderae, all the other raw materials soak 1 to 2 hour, then heated and boiled 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into paste, then Folium Artemisiae Argyi, Fructus Foeniculi, Herba Asari and Radix Linderae steam distillation is extracted, and obtains crystal, is mixed in ointment obtained above; Choose substrate 50 DEG C ~ 60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet virus killing aftershaping.

Described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, adds the fine drug powder that above-mentioned preparation method is obtained, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described powder Chinese patent medicine and substrate is 1: 2 ~ 1: 4; Described tampon is the tampon of afterbody with cotton thread.

External preparation of the present invention uses in menstruation complete 2nd day coloclysis or makes suppository puts into intravaginal, is used in conjunction 15 days once a day.The using method of enema of the present invention: choose crude drug, enema can be prepared by the method that the invention provides embodiment, also can decoct as medicine soup 150-120ml with clear water 500ml, get that supernatant is cool is about 30-40 DEG C to medicine temperature, lateral position is got after advising patient's defecation, insert anus with anal canal and be about 20cm, inhale medicinal liquid with 50ml syringe and slowly pour into the capable retention enema of (or using transfusion device infusion) rectum from anal canal, flat sleeping 30 minutes of slightly padded buttocks after coloclysis, every day coloclysis 1 time, treating 10 days was 1 course for the treatment of.During per rectum administration, medicine at rectal absorption 50%-70%, and can directly not enter 3 Venous systems of pelvic cavity viscera by liver, makes dysmenorrhea rapid rehabilitation under medicine effective concentration effect.

The technique effect that the present invention is useful is, the present invention can only be eased pain to the symptom of dysmenorrhea pain mainly for Western medicine, to simultaneous phenomenon improve not good, thoroughly can not cure dysmenorrhea, and because of side effect larger, can cause nausea, vomit, the gastrointestinal upset such as diarrhoea, also can cause stomatitis, dizziness, tinnitus, blurred vision, the untoward reaction such as erythra, Chinese medicine is started with by entirety, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs demonstrates obvious advantage.For the addiction disorders of blood machine of dysmenorrhea, endocrine disturbance is main pathogeny, in conjunction with the modern pharmacological research achievement of Chinese medicine, explores traditional Chinese medical herbal treatment dysmenorrhea and has vast potential for future development.The present invention has dual regulation to uterus, (namely cause excitation-contraction when uterus shows as in normal state, then cause lax when uterus is in spasticity) and improve circulation, the effect of enhancing body cellular immune function, reaches and promotes that endometrium comes off and repairs, and contributes to the phase of recovering menstruation, amount, color, matter, clinical treatment dysmenorrhea reaches the object for the treatment of must aim at the pathogenesis of disease.

Detailed description of the invention

About dysmenorrhea, motherland's medical science has the record such as " menalgia ", " hanging pain over the perineum ", " through the lower cattle diaphragm of row ".All there is periodically lower abdomen pain women on the occasion of menstrual period or front and back of passing through in ancient Chinese medicine doctor, or pain draws waist sacrum, and very then severe pain is fainted, and is called dysmenorrhea.

Dysmenorrhea one sees the earliest " Medical Treasures of the Golden Chamber the miscellaneous internal diseases in woman arteries and veins disease is also controlled " " leukorrhagia, menstrual disorders, lower abdominal pain and fullness.Through goodbye in January." " General Treatise on the Cause and Symptoms of Diseases " cloud: " married woman's menstrual abdominalgia person, by impairment caused by overstrain vim and vigour, so that body is empty, by air-cooled gas visitor in collaterals of the uterus, fights with mutually with vim and vigour, therefore order pain is also ", and first vertical " menstrual abdominalgia time " they are research and treatment dysmenorrhea based theoretical.

About the etiology and pathogenesis of dysmenorrhea, ancients describe a lot of.Roughly there are three kinds of views: one, cause a disease because of the body void air-cooled heresy of impression.As front " General Treatise on the Cause and Symptoms of Diseases " namely proposes this viewpoint.In addition " Complete Effective Prescriptions for Women's regulating menstruation Men Yueshui go no go trusted subordinate twinge side opinion ": " Mr. and Mrs' man month menalgia person, by impairment caused by overstrain QI and blood, causes and make body empty; Air-cooled gas visitor, in collaterals of the uterus, damages the arteries and veins of appointing in punching, the warp of the hands sun, few the moon.Chong channel, conception vessel all arise from uterus, for sea of channels also.Therefore when water will go the moon, vim and vigour are moved in air-cooled, air-cooledly to hit mutually with QI and blood.Therefore order pain." " Chao Shi cause of disease " also say: " woman enter menstrual abdominalgia person, caused by the sub-collaterals of the uterus of air-cooled gas visitor ".

About the etiology and pathogenesis of dysmenorrhea, it is relevant with physiological environment special before and after ferritic and menstrual period, menstrual period that modern Chinese medicine thinks that it occurs.Between non-menstrual period, punching appoints QI and blood gentle, and paathogenic factor can not cause that punching is appointed, rich the stasis of blood is stagnant or not enough for born of the same parents, therefore pain does not occur, and before and after menstrual period or menstrual period, the sea of blood rushes down excessive by being completely full of, uterus QI and blood by arrogant blood prosperous to through after temporarily empty, QI and blood change is anxious to gather, paathogenic factor is taken the opportunity and does, make QI-blood circulation not smooth, born of the same parents are rich, and menses circulation is obstructed, so that stagnation of QI and blood may bring about pain; Or cause punching appoint a uterus lose in moisten support not flourish and pain.Take a broad view of many doctor's documents, all unanimously think that the basic pathogenesis of dysmenorrhea is " stagnation of QI and blood may bring about pain ", " not Rong Ze pain ".

Dysmenorrhea refer to women pass through before and after or menstrual phase there is hypogastralgia, falling inflation, companion's soreness of waist or other are uncomfortable, degree has a strong impact on live and work quality person.Dysmenorrhea can be divided into primary dysmenorrhea and secondary dysmenorrhea.Primary dysmenorrhea refers to the dysmenorrhea of genitals without obvious pathological changes; Secondary dysmenorrhea refers to the dysmenorrhea caused by pelvic cavity organic disease, is mainly seen in endometriosis and adenomyosis, and the two is all the disease that ectopic endometrium causes.The sampling survey of whole nation woman in menstrual period physiology investigation cooperative groups shows, in China women, the incidence rate of dysmenorrhea is 33.1%, and wherein primary dysmenorrhea accounts for 53.2%.Primary dysmenorrhea is one of common psychosomatic disease of gynecological, because its higher sickness rate causes the concern of people; Endometriosis and adenomyosis in recent years sickness rate are also more and more higher, have caused the common concern of Chinese scholars.But the cause of disease of gynecopathy and gland myopathy and pathogenesis are all not yet completely clear, control is got up more difficult.

Recent domestic scholar starts to grind from EPDML angle to get to the bottom of sb.'s illness, to find the measure of effective treatment and prevention dysmenorrhea.Epidemiology thinks that primary dysmenorrhea is more common in 15-25 year unmarried female, is one of common symptom of adolescence, and has certain hereditary basis; Age of menarche in advance, unhealthy emotion, Bad Eating Habit, the sleep such as depressed and anxiety less, smoking, drink, hyperkinesia is its risk factor; Full-term pregnancy childbirth, Sufficient Sleeping and modest movement are then protection factor.Gynecopathy is apt to occur in 25-45 year women at fertile age, and it has certain hereditary basis; Menarche time advance, cycle time, menostaxis and menorrhagia, dysmenorrhea, motion in menstrual period, heavy burden, sexual intercourse, artificial abortion, places the operations on pelvis such as IUD, dioxin, autoimmune disease history, stature is weedy, too much takes in caffeine, pungent diet, operating pressure is large, and schooling is high, unhealthy emotion, A blood group, endocrine regulation history of disease etc. is the risk factor of endometriosis; Full-term pregnancy, oral contraceptive, smoking etc. are protection factor.Adenomyosis is apt to occur in the multipara of more than 40 years old, and high estrogen level, fecund, repeatedly artificial abortion's dilatation and curettage of uterine history, reproductive tract block for its risk factor.

About dysmenorrhea, motherland's medical science has the record such as " menalgia ", " hanging pain over the perineum ", " through the lower cattle diaphragm of row ".Or cause because of the body void air-cooled heresy of impression; Or for the stagnation of QI or blood stasis cause stasis and pain; And the heresy of cold-damp causes.Etiological pathogenesis is " stagnation of QI and blood may bring about pain " " not Rong Ze pain ".Most report thinks that dysmenorrhea is common has qi depression to blood stasis, cold blood stasis, dampness and heat stasis, deficiency of both QI and blood regulating liver-QI to suffer from a deficiency of the kidney damage five pattern of syndrome.

Radix Paeoniae Rubra is cool in nature, and bitter in the mouth acid, is slightly cold, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving.Yin fluid astringing receives the effects such as antiperspirant, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.Paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Rubra decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.The condition subject such as the blood deficiency deficiency of YIN, the breast abdomen pain over the hypochondriac region, pain in the hepatic region, cholecystitis, gallstone pain, dysentery stomachache, women's menalgia, spontaneous perspiration easy antiperspirant night sweat, sural spasm, spasm of the limbs pain, uneasy lower limb syndrome are suitable edible.

Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.Herba Leonuri, containing the material such as leonurine, Fumaric acid, has the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.External is gynecological's good medicine of activating blood circulation to dissipate blood stasis.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

The Radix Astragali has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, and food stagnation is stagnated, carbuncle from the beginning of or the excess syndrome such as pyretic toxicity Shang Sheng after bursting.The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst." herbal classic " is recorded: " main carbuncle, loses skin ulcer for a long time, evacuation of pus pain relieving.Tonify deficiency, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas strengthening bone and muscle, put on flesh and enrich blood.”

The current domestic Dragon Blood of Sanguis Draxonis mostly is Liliaceae Dracaena cochinchinensis or dracaena cambodiana Pierre resin.Foreign resina draconis is comparatively rare.Yunnan Folium Dracaenae cambodianae is damaged rear flowed out myron can make Sanguis Draxonis through processing.Effect takes promoting blood circulation to remove blood stasis orally, analgesic therapy, external hemostasia and promoting granulation, sore.Cure mainly 1. congestion amenorrhea, dysmenorrhea, postpartum stagnation.2. lump in the abdomen mass in the abdomen, breast ventral spine pain.3. traumatic injury, congestion swells and ache.4. traumatic hemorrhage, ulcer being unable to heal.

A kind of Chinese medicine material of Flos Campsis, has promoting the circulation of blood blood stasis removing, cooling blood, expelling wind dampness removing, heat-clearing and toxic substances removing, and acrid in the mouth acid, cold nature returns liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly menoxenia, amenorrhea lump in the abdomen, puerperal swelling of the breast, skin pruritus. " Amplification on Materia Medica addendum ": Flos Campsis, control the key medicine of pain in blood also, and nourishing YIN victory very, is stamped and keeps and walk alone, in married woman side multiplex what." Nanning City's medicine will ": the merit having eliminating inflammation and expelling toxin, hemostasis and pain-relieving, evacuation of pus granulation promoting, controls red Hakuri.

Rhizoma Cyperi is regulated the flow of vital energy resolving depression; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Rhizoma Corydalis (CorydalisyanhusuoW.T.WangexZ.Y.SuetC.Y.Wu), Papaveraceae, Corydalis perennial herb, another name: Rhizoma Corydalis, corydalis tuber, rhizoma corydalis, Rhizoma Corydalis.Chinese tradition medical material.Mainly originate in Zhejiang and Jiangsu.Its tuber (Rhizoma Corydalis Decumbentis), containing the multiple alkaloid such as corydaline, protopine, through making powder or fluid-acet-extract etc., cures mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.There are analgesia, calmness, syngignoscism.

Rhizoma Chuanxiong enters liver, spleen, three burnt three warps.Function cures mainly activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." detailed outline " carries: " dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine removes vascular smooth muscle (aortic article) spasm (epinephrine, potassium chloride cause).Can also coronary vasodilator be expanded, increase coronary flow.The myocardial ischemia-anoxemia that antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that ligation arteria coronaria causes.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Oletum Trogopterori: Oletum Trogopterori is the feces of Mammalia, flying squirrel section animal trogopterus xanthipes Milne-Edwards (cold number bird), flying squirrel or other nearly edge animal." Oletum Trogopterori " is homophonic with " lipoid " two words.Li Shizhen (1518-1593 A.D.) is released its name and is said: " its excrement name Oletum Trogopterori person, meaning shape as lipoid by the gas of the five elements also ".Oletum Trogopterori is sweet in flavor and warm in property, nontoxic, enters Liver Channel, has dredging blood vessel, effect of eliminating stasis to stop pain; It is gynecological's key medicine.Oletum Trogopterori compatibility Rhizoma Cyperi: Oletum Trogopterori activating blood and removing stasis pain relieving; The pain relieving of Rhizoma Cyperi depressed liver-energy dispersing and QI regulating. Papillary has depressed liver-energy dispersing and QI regulating, effect of promoting blood circulation and stopping pain is used for the treatment of hyperactive liver-QI attacking the stomach side of body rib, gastralgia.

Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension." Bencao Jingshu ": Herba Taxilli, its bitter but sweet flavor, its gas is gentle, cold not hot, admittedly should be nontoxic.It cures mainly in detail, take out its elite for one, therefore function compares Sang Yousheng in Mulberry.Lumbago and children's's stiffback, all time of insufficiency of blood, carbuncle is many due to ying-qi heat.Skin does not fill, due to blood deficiency.Tooth person, originator, beneficial blood then sends out China after blood also, and the sufficient then tooth of kidney qi is hard and an eyebrow is long after bone also.Blood contains then tire peace certainly.Woman's metrorrhagia and internal injury deficiency, all events of blood deficiency interior-heat.Disease more than puerperal, all by blood system, agalactia, also by blood deficiency.Incised wound is then hindered entirely in blood.To come up all diseases, there's no one who doesn't or isn't know and have heat institute to send out by blood deficiency, this property of medicine can beneficial blood, thus also lead also.Hold concurrently and can wet by core, therefore also treat numbness.

Cortex Moutan and Cortex Moutan, Chinese medicine name.For the dry root bark of ranunculaceae peony.Originate in the ground such as Anhui, Sichuan, Henan, Shandong.There is effect of clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis, reducing the asthenic fever.Clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Beriberoid pyretic arthralgia.Control blood deficiency overstrain dysphoria with feverish sensation in the chest palms and soles limbs pain head dusk center of gravity alarmed and panicky cheek red dryness of the mouth and throat heating night sweat to subtract food drowsiness and heat in blood and to fight mutually unsmooth menorrhea umbilicus abdominal distention and pain fever and chills similar to malaria; Control again unmarried girl's blood weak deficiency of YIN Rong Wei discord phlegmatic cough hectic fever human body weakness and emaciation." herbal classic ": " main cold and heat, apoplexy Chi Zong, convulsion, infantile convulsion pathogen, except the hard blood stasis of disease stays house the intestines and stomach, settling five organs, treat carbuncle skin ulcer."

Fructus Rubi plant can be used as medicine, and has multi-medicament to be worth, and its fruit has the effect of kidney invigorating and YANG supporting.Raspberry seed oil belongs to unsaturated fatty acid, can promote that the severe that of prostatic secretions covers.Effect: the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight.Make observation index with the vaginal smear of rat, rabbit and inner membrance section, Fructus Rubi seemingly has estrogen-like effects.Bacteriostasis 100% decoct flat board burrows method, has inhibitory action, also have inhibitory action to vibrio cholera to staphylococcus.The indexs such as the vaginal smear of estrogen-like effects rat, rabbit and inner membrance section show, Fructus Rubi seemingly has estrogen-like effects.

Herba Patriniae nature and flavor hardship is flat, has effect of heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain can be cured.Enter stomach, large intestine, Liver Channel.Cure mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.

Radix Scutellariae (ScutellariabaicalensisGeorgi), another name Radix Scutellariae, tsuchikane tea root, be a kind of plant of Labiatae Scutellaria, belong to semi-wild half kind kind, herbaceos perennial.The root of Radix Scutellariae is a kind of medical herbs, bitter in the mouth, cold in nature, can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.

Fructus Gardeniae: another name Yellow Fructus Gardeniae, Fructus Gardeniae, white toad are the fruits of Maguireothamnus speciosus Fructus Gardeniae.At present, the fruit of Fructus Gardeniae is Chinese medicine, and the l belonging to Ministry of Public Health promulgation criticizes medicine-food two-purpose resource, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence.The diseases such as treatment icterohepatitis, bruise, hypertension, diabetes are usually used at tcm clinical practice.Heat clearing away, pathogenic fire purging, removing heat from blood.Control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.

Herba Eupatorii experiences heat-damp in summer; Cold and heat are had a headache; Accumulate in moistening; Gastral cavity painful abdominal mass is not hungry; Nausea and vomiting; Sweet greasy in mouthful; Disappear truly.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest." herbal classic ": main dredging water passages, kills diseases due to noxious agents produced by various parasites." opinion processed by the public big gun of Zhai ": hemopoietic, regulating QI is with flourish." not Lu ": except accumulation of phlegm in the hypochondrium in the heart.

Cortex Fraxini is Oleaceae plants fraxinus rhynchophylla Hance, Chinese ash, the dry branch skin of sharp leaf Chinese ash or place post Chinese ash or dried bark.Be grown on by hillside, sparse woods, ditch.The ground such as distribution Liaoning, Jilin, Hebei, Henan, the Inner Mongol, Shaanxi, Shanxi, Sichuan.Nature and flavor are bitter, cold.Heat clearing and damp drying Chinese medicine.Cure mainly: heat clearing and damp drying, liver heat removing and eyesight improving, antiasthmatic-antitussive.For pyretic toxicity dysentery, conjunctival congestion and swelling pain, the raw cataracta of order.

Semen Persicae blood stasis removing and clots absorbing, moisturizes laxation.Control amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood." herbal classic ": main blood stasis, blood closes lump in the abdomen, pathogen, kills small worm." not Lu ": only cough with dyspnea, disappear hardness in the epigastrium, and except soldier hits blood cruelly, broken lump in the abdomen, promotes blood circulation, pain relieving." medicine origin ": control stool blood agglomeration." detailed outline ": main stasis migratory arthralgia, hectic fever due to YIN-deficiency, liver-malaria cold and heat, puerperal disorders of blood." modern Practical Chinese medicinal ": control hypertension and chronic cecal inflammation, married woman's uterine hematoma.

External:

Radix Dipsaci, Chinese medicine name.Having another name called shaven head, is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, gains the name because of energy " synthetism of continuous folding ".Autumn excavates, and removing root head and fibrous root, be dried to half-dried with low baking temperature, when bank up " diaphoresis " is to inner virescence, then dries." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians determine in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, and antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”

Folium Artemisiae Argyi is the dried leaves of feverfew Chinese mugwort ArtemisiaargyiLevl.etVant..Most of China area is all produced.Be good with Hubei Qi Zhou (local of Li Shizhen (1518-1593 A.D.)) product person, claim " Artemisia argyi Levl. et Van. var. argyi cv. Qiai ", because it obtains rustic suitable, leaf is thick and floss is many, and as the material of moxibustion treatment, power is maximum.Pluck when summer, flower was not opened, removing impurity, dries or dries in the shade.Folium Artemisiae Argyi acrid in the mouth, hardship, warm in nature, there is warming the meridian for stopping bleeding, dispersing cold for relieving pain, effect of wet down parasite killing.Folium Artemisiae Argyi acrid in the mouth, hardship, warm in nature, nontoxic; Return spleen, liver, kidney channel; Fragrance temperature is loose, can rise to fall to have warming the meridian for stopping bleeding, dispersing cold for relieving pain, and effect of wet down parasite killing, cures mainly menoxenia, dysmenorrhea, infertility, frequent fetal movement, trusted subordinate's cold type of pain, spits blood, epistaxis, and spitting of blood, has blood in stool, metrorrhagia, gestation hemorrhage, chronic dysentery of having loose bowels, leukorrhagia, eczema, scabies, carbuncle, hemorrhoid.Moxibustion treatment all kinds of diseases and ailments.

Flos Carthami, another name: red indigo plant flower thorn Flos Carthami, Latin literary fame: CarthamustinctoriusL. Compositae, Flos Carthami platymiscium, dry tubular flower, is about 1.5 centimetres, orange red, floral tube is carefully narrow, and tip 5 splits, and sliver is narrow linear, long 5 ~ 8 millimeters, 5 pieces, stamen, flower pesticide is yellow, is unified into pipe, exceed outside sliver, its central authorities have stigma to expose.The special fragrance of tool, mildly bitter flavor.To spend, length of a film, color are scarlet, the soft person of matter is good.The ground such as main product Henan, Hunan, Zhejiang, Sichuan.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, swells and ache for amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, traumatic injury, skin infection.Have blood circulation promoting and blood stasis dispelling, wet dissipation goes the effect swollen, but anemia of pregnant woman will be avoided to use, otherwise can cause miscarriage.Flos Carthami can be used for foot bath, contributes to accelerating foot's blood circulation.

The Radix Linderae has pharmacologically active comparatively widely, mainly as follows:

1, the excitation of volatile oil: time for oral administration, have excited corticocerebral effect, and have promotion to breathe, excited cardiac muscle, accelerates blood circulation, the effect of raising blood pressure and diaphoresis.Local topical makes local vascular dilation, and blood circulation accelerates, and relaxes muscle spasm pain.2, bacteriostasis: to staphylococcus aureus, α-hemolytic streptococcus, Bacillus typhi, Bacillus proteus, bacillus pyocyaneus, escherichia coli all have inhibitory action.3, on gastral impact: have the report Radix Linderae to have dual function to gastrointestinal smooth muscle, in addition, the Radix Linderae can increase the secretion of Digestive system.4, anastalsis: experiment in vitro proves, Radix Linderae dry powder can obviously shorten plasma in rabbit recalcification time, promotes blood clotting and good anastalsis.5, other effect: feed rat for a long time with the Radix Linderae, body weight can be made to increase, and have inhibitory action to murine sarcoma-180.Its Borneolum Syntheticum can diaphoresis, excitement, spasmolytic, anthelmintic etc.

Folium Isatidis cures mainly: pyretic toxicity sends out the diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic.This medicine extensive use clinically in recent years, control except above-mentioned all diseases except available, can be used for again expectorant heat stagnation lung, cough up phlegm yellow thick; Especially be usually used in popular second encephalitis, both can be applied to prevention by single, and Radix Bupleuri, Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Radix Scrophulariae, the Radix Rehmanniae etc. can be coordinated again, can removing summer-heat edema caused by disorder of QI, battalion point pyretic toxicity, availablely control various encephalitis b, and comparatively suitable with partial heat type.Folium Isatidis kind commercially available is all over China a lot of, and plant origin is different, again: acanthaceous vegetable acanthaceous indigo.Cruciferae isatis and Folium Isatidis.Polygonaceae plant polygonum tinctorium ait..Leguminous plant Folium et Caulis Indigoferae Tinctoriae.The leaf of above plant, all uses as Folium Isatidis, also all can as the raw material of Indigo Naturalis processed, and except Folium et Caulis Indigoferae Tinctoriae, its root all uses as Radix Isatidis.

Indigo Naturalis is the dry pigment in dicotyledon medicine acanthaceous vegetable acanthaceous indigo, dicotyledon medicine leguminous plant Folium et Caulis Indigoferae Tinctoriae, dicotyledon medicine cruciferae isatis, careless Folium Isatidis or polygonaceae plant polygonum tinctorium ait. leaf.Main product in Fujian, Yunnan, Jiangsu, the ground such as Anhui.In addition, the ground such as Jiangxi, Henan, Sichuan also produces.The performance optimal that is produced from Fujian, claims to build Indigo Naturalis.Nature and flavor are salty-cold.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, purging liver-fire, arresting convulsion.Cure mainly: epidemic febrile disease intenseness of heat, macule, spit blood, spit blood, pharyngalgia aphtha, pediatric epilepsy scared, skin ulcer swells, erysipelas, snake bite and insect sting.

Radix Sophorae Flavescentis is cold in nature, has heat clearing and damp drying, effect of parasite killing, Radix Sophorae Flavescentis bath can remove damp-heat in lower-JIAO, and killing parasites for relieving itching, there is good mitigation to skin pruritus, vegetable Chinese herbal medicine can Bergamot Mint Extract, dredge and restrain pore, removing skin endotoxin contamination, abundant herbal nutrition, promote growth and the reparation of damaged blood vessels neurocyte, recover subcutaneous capillary cell viability, skin reproduction is compacted fine and smooth, plays the effect of beauty and skin care.Pudendal pruritus under treatment belt.To women's leucorrhea with yellow discharge, and male's swelling of the vulva pudendal pruritus all has good therapeutical effect.Treatment eczema scabies.Radix Sophorae Flavescentis bath can remove damp-heat in lower-JIAO, and killing parasites for relieving itching, there is good mitigation to the skin pruritus that eczema scabies causes.Treatment dysuria.Radix Sophorae Flavescentis bath can treat the dysuria that a variety of causes causes, scorching hot puckery pain.Especially to the dysuria that women causes because of gestation, coordinate and take Radix Sophorae Flavescentis decoction effect more.

Specific embodiment 1: the preparation of Tablets agent

Get raw material Herba Patriniae 1000g, Radix Scutellariae 1000g, Cortex Fraxini 1000g, Radix Angelicae Sinensis 1000g, Herba Leonuri 1000g, Oletum Trogopterori 1000g, Radix Astragali 1000g, Herba Taxilli 1000g, Cortex Moutan 1000g, Herba Eupatorii 1000g, Fructus Rubi 1000g, Myrrha 1000g, Sanguis Draxonis 1000g, Fructus Gardeniae 1000g, Radix Paeoniae Rubra 1000g, Flos Campsis 1000g, Rhizoma Cyperi 1000g, Rhizoma Corydalis 1000g, Radix Salviae Miltiorrhizae 1000g, Rhizoma Chuanxiong 1000g, Caulis Spatholobi 1000g, Semen Persicae 1000g, getting all crude drug steeps in water, soak more than 2 hours, add 8 times amount accounting for crude drug gross mass respectively, the water extraction of 6 times amount 2 times, extraction time is 2 hours, 1 hour, merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.The medicinal residues of crude drug said extracted crossed add ethanol, and add the ethanol warm macerating 2 times of 10 times amount of medicinal residues gross weight, 8 times amount respectively, the warm macerating time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm macerating liquid; Warm macerating liquid is evaporated to 1.25 extractum when density is 60 DEG C, and extractum is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.By also 2-in-1 to component 1 and component, when concentrating under reduced pressure relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, inserted in economic benefits and social benefits vacuum concentrator by above-mentioned two kinds of extracting solution, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.60, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again and is condensed into extractum, adds starch and is in harmonious proportion, tabletting after ultraviolet radiation for sterilizing and disinfecting.

Specific embodiment 2: the preparation of capsule of the present invention

Get raw material Herba Patriniae 1300g, Radix Scutellariae 1400g, Cortex Fraxini 1300g, Radix Angelicae Sinensis 1200g, Herba Leonuri 1300g, Oletum Trogopterori 1300g, Radix Astragali 1400g, Herba Taxilli 1300g, Cortex Moutan 1300g, Herba Eupatorii 1300g, Fructus Rubi 1300g, Myrrha 1300g, Sanguis Draxonis 1300g, Fructus Gardeniae 1300g, Radix Paeoniae Rubra 1300g, Flos Campsis 1300g, Rhizoma Cyperi 1300g, Rhizoma Corydalis 1300g, Radix Salviae Miltiorrhizae 1300g, Rhizoma Chuanxiong 1300g, Caulis Spatholobi 1300g, Semen Persicae 1200g, get crude drug clean dry, in 70 DEG C of baking ovens, dry 1-3h, taking-up is placed in cooling in drying baker, 80-100 mesh sieve was pulverized with pulverizer.By for subsequent use for the fine powder sieved, unsifted coarse granule one bubbles in ethanol after 1-2 days, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2g crude drug amount, is then dried to powder, adds the fine powder sieved, ultraviolet disinfection, canned capsule.

Specific embodiment 3: the preparation of oral liquid of the present invention

Get raw material Herba Patriniae 1300g, Radix Scutellariae 1100g, Cortex Fraxini 1300g, Radix Angelicae Sinensis 1200g, Herba Leonuri 1300g, Oletum Trogopterori 1300g, Radix Astragali 1200g, Herba Taxilli 1200g, Cortex Moutan 1300g, Herba Eupatorii 1300g, Fructus Rubi 1200g, Myrrha 1300g, Sanguis Draxonis 1300g, Fructus Gardeniae 1300g, Radix Paeoniae Rubra 1300g, Flos Campsis 1300g, Rhizoma Cyperi 1200g, Rhizoma Corydalis 1300g, Radix Salviae Miltiorrhizae 1300g, Rhizoma Chuanxiong 1300g, Caulis Spatholobi 1300g, Semen Persicae 1300g, be mixed and put into acid and alkali-resistance infusion kettle, at room temperature, 3 ~ 7 days are flooded together with more than 70 degree ethanol, then heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, filter, filtrate is got after separation, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge lixiviating solution, being condensed into pasty state becomes component 2, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the extractum of 1.60, add Mel be in harmonious proportion after ultraviolet sterilization fill.

Specific embodiment 4: the preparation of pill of the present invention

Get raw material Herba Patriniae 1200g, Radix Scutellariae 1100g, Cortex Fraxini 1300g, Radix Angelicae Sinensis 1200g, Herba Leonuri 1200g, Oletum Trogopterori 1100g, Radix Astragali 1200g, Herba Taxilli 1300g, Cortex Moutan 1300g, Herba Eupatorii 1300g, Fructus Rubi 1300g, Myrrha 1300g, Sanguis Draxonis 1200g, Fructus Gardeniae 1300g, Radix Paeoniae Rubra 1300g, Flos Campsis 1200g, Rhizoma Cyperi 1300g, Rhizoma Corydalis 1300g, Radix Salviae Miltiorrhizae 1200g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1300g, Semen Persicae 1200g; Getting all crude drug steeps in water, soaks more than 2 hours, add respectively account for crude drug gross mass 8 times amount, 6 times amount water extraction 2 times, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.The medicinal residues of crude drug said extracted crossed add ethanol, and add the ethanol warm macerating 2 times of 10 times amount of medicinal residues gross weight, 8 times amount respectively, the warm macerating time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm macerating liquid; Warm macerating liquid is evaporated to 1.25 extractum when density is 60 DEG C, and extractum is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.Extract extractum by above-mentioned 4 times to merge, when concentrating under reduced pressure relative density is 80 DEG C 1.28 pasty state, reclaim ethanol, gained pasty state is passed into spray dryer and carries out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 80 DEG C, obtains raw material medicated powder; Add Mel and be twisted into pill.

Specific embodiment 5: the preparation of external enema of the present invention

By described raw material Radix Sophorae Flavescentis 1500g, Radix Scutellariae 1500g, Radix Dipsaci 1500g, Radix Salviae Miltiorrhizae 1500g, Herba Patriniae 1500g, Fructus Gardeniae 1500g, Flos Carthami 1500g, Folium Isatidis 1500g; Put into after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 30%, collects by the raw material fine powder of 100 mesh sieves for subsequent use; The particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution is merged and leaves standstill; The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; In described steps d, crystallization of Folium Artemisiae Argyi 1500g, Indigo Naturalis 1500g and Radix Linderae 1500g distillation being vaporized to obtain, is dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.46, stir evenly after adding the crystalline powder of fine powder and the distillation of sieving, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be condensed into pasty state, ultraviolet virus killing after use.

Specific embodiment 6: preparation process when external preparation of the present invention is suppository is:

By described crude drug Radix Sophorae Flavescentis 1500g, Radix Scutellariae 1500g, Radix Dipsaci 1500g, Radix Salviae Miltiorrhizae 1500g, Herba Patriniae 1500g, Fructus Gardeniae 1500g, Flos Carthami 1500g, Folium Isatidis 1500g, soaks 1 to 2 hour, then heated and boiled 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into paste, then Folium Artemisiae Argyi 1500g, Indigo Naturalis 1500g and Radix Linderae 1500g steam distillation is extracted, and obtains crystal, is mixed in ointment obtained above; Choose substrate 50 DEG C ~ 60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet virus killing aftershaping.Described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, adds the fine drug powder that described preparation method is obtained, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described powder Chinese patent medicine and substrate is 1: 2 ~ 1: 4; Described tampon is the tampon of afterbody with cotton thread.

External preparation of the present invention uses in menstruation complete 2nd day coloclysis or makes suppository puts into intravaginal, is used in conjunction 15 days once a day.

The using method of enema of the present invention: choose crude drug, enema can be prepared by the method that the invention provides embodiment, also can decoct as medicine soup 150-120ml with clear water 500ml, get that supernatant is cool is about 30-40 DEG C to medicine temperature, lateral position is got after advising patient's defecation, insert anus with anal canal and be about 20cm, inhale medicinal liquid with 50ml syringe and slowly pour into the capable retention enema of (or using transfusion device infusion) rectum from anal canal, flat sleeping 30 minutes of slightly padded buttocks after coloclysis, every day coloclysis 1 time, treating 10 days was 1 course for the treatment of.During per rectum administration, medicine at rectal absorption 50%-70%, and can directly not enter 3 Venous systems of pelvic cavity viscera by liver, makes dysmenorrhea rapid rehabilitation under medicine effective concentration effect.

Toxicology test:

Pharmacological toxicity is tested

One, antibacterial experiment

In body, antibacterial tests result shows, the animal of the present invention to escherichia coli and Bacillus proteus has significant protective effect, can subtract the development of the state of an illness, reduces the mortality rate of animal; Antimicrobial test result shows, the prostatitis antibacterial of urinary system bolt to urinary system infection has antibacterial and bactericidal action in various degree; The prostatitic experimental result that affects of experimental rat is shown, the present invention can anti-bacteria infect after the weightening finish of urinary system body of gland, slow down the development of the state of an illness, suppress the Pathological morphologic change of prostata tissue; Within after administration 2-5 hour, the urine volume of animal can be made obviously to increase; Obvious cooling effect in 5 hours after the rabbit body temperature rising administration that fresh yeast is caused; The animal auricular concha swelling that xylol causes and have obvious inhibitory action to granuloma induced by implantation of cotton pellets tissue, and suppress the increase of capillary permeability; Certain inhibitory action is had to the pain that chemical substance stimulating animal peritoneum or thermal stimulus animal body surface cause.

Result of the test shows: Chinese medicine preparation experiment safety of the present invention.This medicine is 1: 150 to group B streptococcus, staphylococcus aureus, colibacillary minimal inhibitory concentration, gonococcus is 1: 150, Candida albicans is 1: 300, it is 5 minutes to the time of killing during 1: 20 dilution factor, be 10 minutes when 1: 50, being 20 minutes when 1: 100, is 40 minutes when 1: 200, is 8 hours when 1: 400.

Two, animal acute toxicity test research:

When the present invention adopts rectal delivery, the maximum dosage-feeding on the one recording mice is 62.7g/kg (in medicated powder), be about 1567.5 times (people is in 60kg) intending clinical people's consumption, the maximum dosage-feeding 62.7g/kg (in medicated powder) on the one of rat, is about 1567.5 times that intend clinical people's consumption.The equal Continuous Observation of laboratory animal one week, its outward appearance sign, the mental status, diet, drinking-water, feces etc. are showed no obvious abnormalities.At the end of experiment, all healthy survival of animal, body weight increases.

Three, long-term toxicity test for animals research:

This test establishes medicine of the present invention high, in, low dose group and Matrix controls group, blank group, rectal delivery is adopted to give rat, dosage is respectively 3.2, 2.4 and 1.6g/kg (in medicated powder), be equivalent to intend 80 of clinical patient consumption [0.04g (medicated powder)/kg], 60 and 40 times, successive administration 2 months, in administration process, the body weight of each administration group and matrix group rat, dietary amount, outward appearance sign, behavioral activity, the mental status, hair color, feces character compares with blank group, no significant difference (P > 0.05), the weight of animals increasing value and Main Organ Coefficients and blank group comparing difference are not significantly (P > 0.05), hematology and the indivedual index of blood parameters check result administration group and blank group comparing difference are significantly (P < 0.05), but convalescent period terminates rear discrepant hematology and blood parameters has recovered normal all, other indexs and blank comparing difference are not significantly (P > 0.05), administration phase and convalescent period histological examination high dose group animal main organs compare with blank group and have no notable difference, have no slowness toxicity to occur.

Four, animal local excitation test:

The allergic reaction on guinea pigs of enema of the present invention and Rat-rectum medication irritation test.

Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.

Five, vaginal mucomembranous irritant test result

1. test method:

After laboratory animal is quarantined 3 days, select 18 above-mentioned healthy rabbits, be divided into three groups at random, often organize each 6, be respectively: blank, excipient control, enema group of the present invention (by application liquid 5 times of concentration).Be placed in excipient control group and the intravaginal of tested material treated animal with the sterilizing cotton sliver leaching of suitable size with sterile saline and tested material respectively, contact 6 hours with vaginal mucosa, after 24 hours, put to death animal.Taking-up topical vaginal tissue, observes pathological changes situation.

2, result of the test: vaginal mucomembranous irritant test result

Pharmacodynamics test

Intestinal adhesion clinical manifestation is with knowing that block up disease conforms to, and as abdominal mass, abdomen localized pain is also shown in hemorheology change etc.Therefore manually can manufacture animal intestine adhesion as Blood stasis pathological model.

Experimental technique: get some, body weight is 300 ± 20 grams of female rat, be placed in after being full of the interior anesthesia of ether gas container, abdominal part cropping, sterilization, aseptically perform the operation, longitudinally 3 ~ 4cm otch is cut along abdomen median line, after finding vermiform appendix, at distance vermiform appendix cecum 0.5cm place, do the stringer holostrome mouth that a 2.0 ~ 2.5cm is long, the feces of vermiform appendix intracavity is all removed totally with aseptic absorbent cotton, then otch No. 1 silk thread densification is sewed up (notching edge ploughs under vermiform appendix intracavity completely), two-layer pass abdomen.And Post operation rat is divided into 5 groups at random, be respectively enema of the present invention (method shown in embodiment 5 obtains) 10g/kg, 5g/kg group, DANER FUKANG JIANGAO agent (Kuning Dianhong Pharmaceutical Co., Ltd.'s development) 10g/kg group, the scorching clean group of 30g/kg group of woman and model group 30ml/kg ordinary water.Post operation second day, each group anus intraperitoneal administration respectively, every day 1 time, continuous 7 days.Within 8th day, by sacrifice of animal, cut open the belly, observe intestinal adhesion degree, adhesion incidence rate and average adhesion place number.Adhesion grading standard is as follows: "+" singly locates adhesion, and matter is crisp, cannot label taking this; " ++ " singly locates adhesion, and firmly, easy label taking originally; " +++ " two places adhesion, firmly, easy label taking is originally; " ++++" the above adhesion in three places, firmly, easy label taking is originally.Experimental result sees the following form:

Note: compare ※ ※ p < 0.01 with model

Upper table result shows, adopts said method can cause intestinal adhesion model (model all intestinal adhesion occurs).Each administration group adhesion number of cases, compares with model group, and through X2 inspection, height agent 10g/kg group of the present invention and DANER FUKANG JIANGAO agent group all have obvious diversity (P < 0.01), and all the other two groups of effects are not obvious.Observe from adhesion degree, each administration group forms adhesion, the adhesion degree of large intestine also than model group be gently (because of each administration group number of cases very little, cannot statistical disposition).Viewed from average adhesion number, each administration group is all few according to model group.Above-mentioned experimental result shows, enema of the present invention has certain anti-experimental character intestinal adhesion effect.

Test 2. In vitro Bactericidal Experiments

Culture medium: broth bouillon, broth agar culture medium, blood plate, chocolate are dull and stereotyped; Strain: select the strains such as escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, Bacillus proteus, gonococcus, γ-streptococcus, micrococcus catarrhalis; Method: dilution method, by high, medium and low for enema solution of the present invention dosage meat soup from 1: 5,1:50 to 1: 100 make doubling dilution, often pipe is containing medicinal liquid 2ml, 9th pipe, for contrasting without medicine, often adds dilution bacterium liquid 1, hatches 18h for 37 DEG C in pipe, visual results, pastille least concentration is still the minimal inhibitory concentration (MIC) of this medicine in obvious haze-free pipe.Gonococcus is undergrowth in meat soup, uses chocolate plate dilution method instead and surveys minimal inhibitory concentration.As following table:

Bacterial strain	Minimum inhibitory concentration (MIC) (mg/ml)
		Candida albicans	4.135
Gonococcus	11.8
		γ-streptococcus	27
Bacillus pyocyaneus	5.95
		Escherichia coli	51
Micrococcus catarrhalis	23
		Staphylococcus aureus	6.18

Result shows that the present invention is all 5mg/ml to the minimal inhibitory concentration of escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, Bacillus proteus, micrococcus catarrhalis, γ-streptococcus, and gonococcus is 10mg/ml.Obvious bacteriostasis is all had to escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, Bacillus proteus, micrococcus catarrhalis, γ-streptococcus, gonococcus.

3, antiinflammatory action test

Medicament selection: experimental group is enema of the present invention (embodiment method is obtained), matched group is first nitre file sheet, commercially available.Experimental animal: SD rat.

Inhibitory action to rat pedal swelling caused by Ovum Gallus domesticus album: select experiment with rat, 220 ~ 300g, male and female half and half, 10/group, left ankle subcutaneous injection 100% egg clear liquid 0.03ml/ only causes inflammation.Each measurement joint girth after 1h, 2h, 4h, 6h.Obtaining each time two joints of foot girth difference is swelling, and amalgamation result, carries out the comparison of inflammation suppression ratio between each group.As following table:

Result shows that (high dose) of the present invention has the inhibitory action of highly significant to rat paw edema.To sum up result shows, enema of the present invention has obvious antiinflammatory action.

By above-mentioned pharmacodynamics test, confirm that enema of the present invention all has obvious bacteriostasis to escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, Bacillus proteus, micrococcus catarrhalis, γ-streptococcus, gonococcus; Topical has resist inflammation on repercussive function to Ovum Gallus domesticus album rat paw edema.

Clinical data

(1) physical data

1.1 case sources

Case group patient is all from Qingdao Affiliated Hospital of university of TCM, the People's Hospital of city Out-patient Clinic of Department of Gynecology and inpatient.Dysmenorrhea patient 120 example is collected altogether from year October in January, 2012 to 2012.

1.2 ordinary circumstance

1.2.1 case group

120 routine dysmenorrhea patient ages 14 ~ 45 years old, average 27.86 ± 6.84 years old; Married 65 examples (54.17%), unmarried 54 examples (45%), divorced l example (0.83%).Primary dysmenorrhea (PD) patient 80 example, secondary dysmenorrhea (SD comprises endometriosis, adenomyosis) patient 40 example; Simple gynecopathy patient 2l example in secondary dysmenorrhea patient, simple gland patients with myopathy 12 example, gynecopathy merges gland patients with myopathy 7 example; Through clinical diagnosis person 26 example, the operation person of making a definite diagnosis 14 example, wherein postoperative recurrence person is 6 examples.All patients carry out classification and scoring according to its dysmenorrhea symptom, are divided into slight 20 examples, moderate 65 example, severe 35 example.

Infertile person 13 example is merged in 120 routine dysmenorrhea patients, all from secondary dysmenorrhea patient (endometriosis, adenomyosis), wherein primary infertility 6 example, secondary infertility 7 example; Merge patients with uterine myoma 10 people, wherein 2 examples are from primary dysmenorrhea group, and 8 examples are from secondary dysmenorrhea group.

1.3 investigation content

The ordinary circumstances such as survey items has age, wedding condition, blood group, height, body weight, occupation, education degree, menstruation, leukorrhagia situation, at ordinary times symptom, motherhood history, contraceptives, history of operation, previously dysmenorrhea history, the content such as family history and living habit, and the subordinate list such as World Health Organization's life quality chart abridged table (WHOQOL.BREF), formulate corresponding application form according to investigation content, to the person of including in, inquired and record by special messenger doctor.

(2) Standards of Chinese Medical Syndrome Differentiation

1. month through or see and postpone, amount is large, dim and have tired piece or as decoction of black soybean sample through color; 2. complexion is rubescent; The colour of skin is rubescent, and two cheeks are red; 3. nausea and vomiting, waist bones of the body distending pain or rectal tenesmus; 4. the dim Huang of tongue is greasy; 5. floating pulse, wherein cardinal symptom is indispensable, and simultaneous phenomenon possesses 2 and can diagnose.

(3) dysmenorrhea grade scale

Draft with reference to " guideline of clinical investigations of new Chinese medicine treatment dysmenorrhea " (version in 1993):

1. severe: menstrual period or lower abdomen hurt like hell before and after it, feel restless, have a strong impact on work, study and daily life, must lie up, ache with waist, complexion is looked into the distance white, dripping cold sweat, extreme cold of the limbs, vomiting and diarrhoea, or rectal tenesmus, adopt pain relieving measure without obvious alleviation, dysmenorrhea symptom integral is more than 14 points;

2. moderate: menstrual period or lower abdomen hurt like hell before and after it, companion's waist is ached, nausea and vomiting, and extremity are not warm, and postpone separating with pain relieving measure, dysmenorrhea symptom integral is at 8 ~ 13.5 points;

3. slight: menstrual period or before and after it lower abdomen pain obvious, companion's waist is ached, but can adhere to work, and without General Symptoms, sometimes must take analgesic, dysmenorrhea symptom integral is below 8 points.

(4), exclusion standard

(1) Syndrome Differentiation of Traditional Chinese Medicine does not belong to damp and hot addiction resistance person; (2) dysmenorrhea caused by pelvic inflammatory disease, endometriosis, uterus tumor is confirmed on inspection; (3) to known applications drug allergy person; (4) the severe primary diseases such as cardiovascular and cerebrovascular vessel, liver, kidney and hemopoietic system are associated with, psychotic; (5) do not meet inclusive criteria, not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person; (6) do not agree to reception test group or treatment of control group, do not sign the patient of Informed Consent Form.

Concrete condition illustrates: 1. medication is more than 1 menstrual cycle person, should enter curative effect statistics; More than medication 1 cycle (comprising 1 cycle) invalid stop using or use other similar therapeutic medicines instead, should by invalidation, not in the scope of coming off, the present invention treats in the observation of curative effect of qi depression to blood stasis dysmenorrhea; 2. medication does not reach the experimenter of 9 days, can be considered the case that comes off; 3. the patient that pair midway proposes to exit test by patient clearly will record reason; Medication is passed through and last administration time; 4. the patient of pair lost to follow-up or institute's further consultation that do not come in time, should make great efforts by telephone questionnaire reason, investigate its medication process, last administration time, and keep a record; 5. evaluation index when itemized record stop, stopping test or come off will conscientious record with the relation of test, analyzes and stops case may affect research conclusion; 6. keep the raw data of all rejectings and the case that comes off.

Five, grouping and test method

(1) EXPERIMENTAL DESIGN

This research adopts clinical experimental study method, selects ibuprofen modified release capsule as standard control medicine, using the present invention as test group, Chinese medicine pharmacy of institute decocts to 200ml by prescription unification by me, sealing, and menstruation first day starts oral, day 1 dose, and sub-service sooner or later, serve on 3 days; With ibuprofen modified release capsule group for matched group, the same day in menstrual period oral ibuprofen slow releasing capsule 30mg, 1 time/d, namely pain only stops using, being used in conjunction 3 menstrual cycle was 1 course for the treatment of, and observing time is 3 months, by comprehensive therapeutic effect, disease curative effect, the change of primary symptom and simultaneous phenomenon, and the change etc. of check result as erythrocyte sedimentation rate value of Binding experiment room carries out clinical observation to two kinds of these diseases of Drug therapy.

Whole process of the test arrangement is made a house call for 6 times, make a house call for 1st time and be arranged in case screening, informed consent postscript is signed patient, carry out corresponding inquiring, health check-up and lab testing, if patient meets inclusion criteria, a medicine numbering will be distributed in order, i.e. random number, and arrange to enter first month through cycle therapy; Make a house call for 2nd time after being arranged in treatment menstrual cycle, further consultation before menstrual cycle next time; Make a house call for 3rd time after being arranged in treatment two menstrual cycle, under further consultation before menstrual cycle successively, treatment 3 menstrual cycle are 1 course for the treatment of continuously; After drug withdrawal, follow up a case by regular visits to 3 months continuously, monthly to patient's telephone questionnaire once, the improvement of clinical symptoms and sign are detected, evaluate Drug safety and effectiveness.

(2) sample size

Selector closes and states the 80 cases of test case standard, often organizes each 40 examples.

(3) medicine and usage

1. medicine name

Trial drug: the present invention, by Shandong, Chinese medicine pharmacy of institute of traditional Chinese medicine provides, prescription: Herba Patriniae 12g, Radix Scutellariae 13g, Cortex Fraxini 12g, Radix Angelicae Sinensis 13g, Herba Leonuri 13g, Oletum Trogopterori 12g, Radix Astragali 13g, Herba Taxilli 13g, Cortex Moutan 13g, Herba Eupatorii 12g, Fructus Rubi 13g, Myrrha 12g, Sanguis Draxonis 13g, Fructus Gardeniae 13g, Radix Paeoniae Rubra 13g, Flos Campsis 12g, Rhizoma Cyperi 12g, Rhizoma Corydalis 12g, Radix Salviae Miltiorrhizae 13g, Rhizoma Chuanxiong 12g, Caulis Spatholobi 12g, Semen Persicae 12g; External: Radix Sophorae Flavescentis 15g, Herba Patriniae 15g, Folium Isatidis 15g, Radix Dipsaci 14g, Radix Salviae Miltiorrhizae 13g, Radix Linderae 12g, Fructus Gardeniae 12g, Indigo Naturalis 13g, Folium Artemisiae Argyi 12g, Radix Scutellariae 12g, Flos Carthami 13g; Use in menstruation complete 2nd day coloclysis or make suppository and put into intravaginal, be used in conjunction 15 days once a day.The using method of enema of the present invention: choose crude drug, enema can be prepared by the method that the invention provides embodiment, also can decoct as medicine soup 150-120ml with clear water 500ml, get that supernatant is cool is about 30-40 DEG C to medicine temperature, lateral position is got after advising patient's defecation, insert anus with anal canal and be about 20cm, inhale medicinal liquid with 50ml syringe and slowly pour into the capable retention enema of (or using transfusion device infusion) rectum from anal canal, flat sleeping 30 minutes of slightly padded buttocks after coloclysis, every day coloclysis 1 time, treating 10 days was 1 course for the treatment of.During per rectum administration, medicine at rectal absorption 50%-70%, and can directly not enter 3 Venous systems of pelvic cavity viscera by liver, makes dysmenorrhea rapid rehabilitation under medicine effective concentration effect.

Control drug: ibuprofen modified release capsule, is produced by Sino-America Tianjin Shike Pharmaceutical Co., Ltd., authentication code: the accurate word H10900089 of traditional Chinese medicines, batch number: 08110660, every 0.39, specification: 20/box.

2. test the course for the treatment of: being used in conjunction 3 menstrual cycle was 1 course for the treatment of, judged curative effect after observing 3 menstrual cycle.

3. drug combination: duration of test must not add with in relevant with treatment primary disease, Western medicine product and other means.

(2) tcm syndrome efficacy assessment standard (with reference to nimodipine method)

Statistical analysis plan: application SPSS13.0 statistical package, after homogeneity of variance is analyzed, measurement data compares employing t inspection, and enumeration data adopts x ²inspection, ranked data adopt rank test, compare and adopt paired t-test " (note: all represent mean with-x below) in group

Experiment: patient 100 example meeting inclusive criteria is collected in this clinical trial altogether, and patient dependence is good, and no one is lost to follow-up.

The present invention treats the observation of curative effect of qi depression to blood stasis dysmenorrhea

The comparison (n, %) of table 1 liang group patient therapeutic effect of syndrome

Group	Number	Recovery from illness	Effective	Effectively	Invalid	Total effective rate
							Test group	50	14(28)	16(32)	15(30)	5(10)	45(90)
Matched group	50	6(12)	12(24)	17(34)	15(30)	35(70)

The comparison of two groups of patient's disease curative effects is used and is expanded inspection calculating, x ²=12.431, P=0.010, two groups of cure rates, obvious effective rate, the group difference of effective percentage, inefficiency, total effective rate all has statistical significance.

After table 2 liang group patient treatment, dysmenorrhea integral difference compares (-x ± s)

Group	n	Integral difference before and after treatment	t	p
					Test group	50	2.98±3.233	2.331	0.023
Matched group	50	5.44±4.105

The difference of the comprehensive therapeutic effect between two groups before and after patient treatment calculates through the t inspection of two independent samples, and P<0.05, the two curative effect has statistical significance.

Compare in the group of table 3 liang group Patient Global curative effect

The comparison (-x ± s) of pain degree integration before and after table 3 liang group patient treatment

Group	n	(divide) before treatment	After treatment (dividing)	t	P
						Test group	50	9.28±2.693	5.45±2.834	11.34	0.000
Matched group	50	9.89±2.795	6.57±2.123	10.12	0.000

Calculate through paired t-test, P<0.001, before and after two groups of patient treatments, therapeutic effect of syndrome integral contrast has significant difference.

Table 4, two groups of pain relieving onset times compare (n/%)

Group	n	Invalid	30min	1h	1.5h	2
							Test group	50	2(5)	17(42.5)	9(22.5)	8(20)	4(10)
Matched group	50	3(7.5)	26(65)	10(25)	1(2.5)	0

Before and after table 5 liang group treatment, the hypogastralgia time compares (n)

L () calculates through the rank test of matched-pair design data, before and after test group treatment, the hypogastralgia time compares, Z=2.611, P=0.009; Before and after treatment of control group, the hypogastralgia time compares; Z=2.426, P=0.00, before and after two groups of treatments, the difference of hypogastralgia time all has statistical significance.

(2) under completely randomized design, the rank test of two groups of ordered set data calculates, Z=2.426, P=0.015, two groups of treatments

The rear hypogastralgia time compares, and group difference has statistical significance, and the average sum of ranks of test group and matched group is 35.30,45.70.

The comparison of table 6. liang group patient simultaneous phenomenon curative effect

After table 6 liang group treatment, simultaneous phenomenon improvement situation compares (n)

Calculating through separating inspection, comparing before and after test group treatment, x ²=12.614, P=0.047, difference has statistical significance: compare before and after treatment of control group, x ²=7.030, P=0.436, no significant difference.

The comparison of table 7 liang group patient secondary efficacy index

The comparison (-x ± s) of erythrocyte sedimentation rate value before and after table 7 liang group patient treatment

Group	n	Before treatment (mm/h)	After treatment (mm/h)	t	P
						Test group	50	12.32±2.31	14.35±2.642	2.43	0.011
Matched group	50	12.07±1.88	13.23±2.565	2.12	0.023

Before and after two groups of patient treatments, erythrocyte sedimentation rate value calculates through paired t-test, P<0.05, and the difference before and after treatment has statistical significance

1. safety detects: in treatment and observation process thereof, routine blood test, the two just routine examination before and after of the present invention group of patient treatment, electrocardiogram, hepatic and renal function all do not find obvious exception.

2. untoward reaction: in treatment and observation process thereof, do not have patient to tell any discomfort and allergic phenomena.

Discuss

Dysmenorrhea is one of modal disease of gynecological, and its incidence rate report differs, and account for 42% ~ 90%, wherein severe pain is through accounting for 18%.Dysmenorrhea is a disease that is long-term, easily recurrent exerbation, can accompany nausea and vomiting, dripping cold sweat, deadly cold hand and foot, very then faint, affect life and work more time serious, totally unfavorable to the physical and mental health of women.In treatment, the appearance of PGSI, the sickness rate of this disease is greatly reduced, ibuprofen modified release capsule has stronger antiinflammatory, pain relieving, refrigeration function, by suppressing prostaglandin synthetase, thus suppresses the synthesis of prostaglandin, produce anti-inflammatory analgesic effect, therefore ibuprofen modified release capsule is premenstruum, and use has the effect prevented irritation, using menstrual period has spasmolytic, analgesic activity, is characterized in that administration is easy, instant effect.But because its symptom mainly for its pain is eased pain, improve not good to simultaneous phenomenon, thoroughly can not cure dysmenorrhea, and because of side effect larger, can cause nausea, vomit, the gastrointestinal upset such as diarrhoea, also can cause stomatitis, dizziness, tinnitus, blurred vision, the untoward reaction such as erythra, therefore still can not think that oral ibuprofen slow releasing capsule is the Perfected process for the treatment of dysmenorrhea.Chinese medicine is started with by entirety, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs demonstrates obvious advantage.For " addiction blood " pathogenesis of dysmenorrhea, endocrine disturbance is main pathogeny, in conjunction with the modern pharmacological research achievement of Chinese medicine, explores traditional Chinese medical herbal treatment dysmenorrhea and has vast potential for future development.

Claims

1. treat the Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea for one kind, it is characterized in that, in described Chinese medicine composition, oral preparations comprises the crude drug of following parts by weight: Herba Patriniae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Cortex Fraxini 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, in described Chinese medicine composition, external preparation comprises the crude drug of following parts by weight: Radix Sophorae Flavescentis 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Indigo Naturalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, the Radix Linderae 10 ~ 20 parts, Folium Isatidis 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami.

2. treat the Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea according to claim 1, it is characterized in that, in described Chinese medicine composition, oral preparations comprises the crude drug of following parts by weight: Herba Patriniae 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Cortex Fraxini 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Oletum Trogopterori 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Herba Eupatorii 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, in described Chinese medicine composition, external preparation comprises the crude drug of following parts by weight: Radix Sophorae Flavescentis 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Radix Dipsaci 10 ~ 15 parts, Indigo Naturalis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, the Radix Linderae 10 ~ 20 parts, Folium Isatidis 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami.

3. treat the Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea according to claim 1, it is characterized in that, in described Chinese medicine composition, oral preparations comprises the crude drug of following parts by weight: Herba Patriniae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Cortex Fraxini 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Myrrha 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Flos Campsis 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, 10 ~ 15 parts, Semen Persicae, in described Chinese medicine composition, external preparation comprises the crude drug of following parts by weight: Radix Sophorae Flavescentis 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Indigo Naturalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, the Radix Linderae 10 ~ 15 parts, Folium Isatidis 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Folium Artemisiae Argyi 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami.

4. according to any one of claims 1 to 3, treat the Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea, it is characterized in that, in described Chinese medicine composition, oral preparations dosage form is: sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, plaster or syrup; In described Chinese medicine composition, external preparation formulation is: hot compress agent, suppository and enema.

5. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea, it is characterized in that, when in described Chinese medicine composition, the dosage form of oral preparations is oral liquid, its preparation process comprises:

6. treat the preparation method of the Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea according to claim 4, it is characterized in that, in described step a, getting all crude drug steeps in water, soak more than 2 hours, add the water extraction 2 times of 8 times amount of crude drug gross weight, 6 times amount respectively, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.

7. treat the preparation method of the Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea according to claim 4, it is characterized in that, in described step b, the medicinal residues of crude drug said extracted crossed add ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, extractum is added the extraction into ethyl acetate secondary accounting for its 4 times amount, extract has reclaimed ethyl acetate, become extractum, obtain component 2.

8. treat the preparation method of the Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea according to claim 4, it is characterized in that, in described step c, extract extractum by above-mentioned two kinds to merge, when concentrating under reduced pressure relative density is 80 DEG C 1.35 extractum, reclaim ethanol, above-mentioned two kinds of extracting solution are inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the extractum of 1.60, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again and is condensed into extractum, and after adding Mel mediation, ultraviolet sterilization is canned.

9. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine composition of damp and hot addiction resistance type dysmenorrhea, it is characterized in that, when the external preparation of described Chinese medicine composition is suppository, its preparation process is:

By described crude drug except Folium Artemisiae Argyi, Indigo Naturalis and the Radix Linderae, all the other crude drug soak 1 to 2 hour, then heated and boiled 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into paste, then Folium Artemisiae Argyi, Indigo Naturalis and Radix Linderae steam distillation is extracted, and obtains crystal, is mixed in ointment obtained above; Choose substrate 50 DEG C ~ 60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet virus killing aftershaping.

10. treat the preparation method of damp and hot addiction resistance type dysmenorrhea suppository according to claim 9, it is characterized in that, described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, and add the fine drug powder that preparation method described in claim 9 is obtained, stirring in water bath is even, be mixed into the liquid of thickness, be poured in plastic shape-forming pipe, insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described powder Chinese patent medicine and substrate is 1: 2 ~ 1: 4; Described tampon is the tampon of afterbody with cotton thread.