CN104398987A

CN104398987A - Chinese medicinal composition for treating cold accumulation-caused blood stasis type dysmenorrhea

Info

Publication number: CN104398987A
Application number: CN201410699529.7A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Shen Da New And High Technology Development Corp Ltd
Current assignee: Qingdao Shen Da New And High Technology Development Corp Ltd
Priority date: 2014-11-27
Filing date: 2014-11-27
Publication date: 2015-03-11

Abstract

The invention provides a Chinese medicinal composition for treating the cold accumulation-caused blood stasis type dysmenorrheal. An oral preparation of the Chinese medicinal composition adopts the following drug substances: rehmannia glutinosa, epimedium herb, fennel, angelica sinensis, motherwort, trogopterus dung, astragalus mongholicus, parasitic loranthus, the root bark of the peony tree, cinnamomum cassia, raspberry, myrrh, dragon blood, radix curcumae, red paeony root, Chinese trumpet creeper, rhizoma cyperi, rhizoma corydalis, the root of red-rooted salvia, ligusticum chuanxiong hort, caulis Spatholobi and rhizoma sparganii; an external preparation of the Chinese medicinal composition adopts the principle that the Chinese medicinal composition is prepared from fennel, fructus cnidii, ground beeltle, teasel root, herba asari cum radice, the root of red-rooted salvia, the root of three-nerved spicebush, herba patriniae, cassia twig, mugwort, szechwan Chinaberry fruit and red flower. The Chinese medicinal composition has a bidirectional regulating effect on a uterus, that is when the uterus is in a normal state, the uterus is enabled to be excited and contracted and when the uterus is in a spasm state, the uterus is enabled to be relaxed and circulation is improved, the Chinese medicinal composition has an effect of reinforcing the immunologic function of organism cells, achieves an effect of promoting falling and repairing of endometrium, is helpful for recovering the period, quantity, color and quality of menstruation, clinically treats dysmenorrheal and fulfills the aim of treating the disease from the primary cause.

Description

A kind of Chinese medicine composition for the treatment of menorrhalgia of cold-stagnation and blood-stasis type and preparation method thereof

Technical field

The present invention relates to medicine configuration product, the particularly a kind of Chinese medicine composition for the treatment of menorrhalgia of cold-stagnation and blood-stasis type and preparation method thereof containing deriving from plant composition.

Background technology

Dysmenorrhea refer to women pass through before and after or menstrual phase there is hypogastralgia, falling inflation, companion's soreness of waist or other are uncomfortable, degree has a strong impact on live and work quality person.Dysmenorrhea can be divided into primary dysmenorrhea and secondary dysmenorrhea.Primary dysmenorrhea refers to the dysmenorrhea of genitals without obvious pathological changes: secondary dysmenorrhea refers to the dysmenorrhea caused by pelvic cavity organic disease, is mainly seen in endometriosis and adenomyosis, and the two is all the disease that ectopic endometrium causes.Three, because of its high incidence, becomes common gynecological disease, brings huge injury to women's physical and mental health, causes the common concern of Chinese scholars.

All there is periodically lower abdomen pain women on the occasion of menstrual period or front and back of passing through in ancient Chinese medicine doctor, or pain draws waist sacrum, and very then severe pain is fainted, and is called dysmenorrhea.Ancient Chinese medicine is without the record of " endometriosis " and " adenomyosis ".

Show as that enclosed mass in abdomen is tangible to be levied, abdominal pain during menstruation, the symptoms such as menoxenia, with the category belonging to the traditional Chinese medical science " addiction abdominal mass ", " dysmenorrhea ", " loss of fecundity " and " menoxenia ".Think that its main pathogenesis is for " most report thinks that dysmenorrhea is common has qi depression to blood stasis, cold blood stasis, dampness and heat stasis, deficiency of both QI and blood regulating liver-QI to suffer from a deficiency of the kidney damage five pattern of syndrome for stagnation of QI and blood may bring about pain, ' not Rong Ze pain ".

The traditional Chinese medical science thinks that dysmenorrhea is a disease that is long-term, that easily recur, and menstrual period or puerperal experience cold-evil, or the cold and cool raw food of surfeit, prolonged illness enters the reasons such as bloodization is tired can cause dysmenorrhea, common with cold blood stasis card clinically, cold blood stasis is demonstrate,proved: premenstrual or cold-type pain in the lower abdomen during menstruation, pain alleviated while getting warmth; Delayed menstrual cycle, amount is few; Menses are dim and have stasis of blood block or as decoction of black soybean sample; Fear of cold, the hands and feet being not warm; Profuse leukorrhea; Tongue fur is white or greasy, stringy pulse or heavy tight.Cold blood stasis causes the situation of dysmenorrhea very general.Women take blood as this, belongs to cloudy; Cold being a kind of YIN pathogen, People of the same tastes and habits like to be together, and women itself easily feels cold-evil and causes gynaecopathia.And " cold being a kind of YIN pathogen, its gas spasm " YANG QI being easily injured by cold, fight mutually with cloudy blood, thus affect QI-blood circulation; Women or experience cold-evil, or eating cold and uncooked food excessively then blood be cold coagulation, run smooth, " stagnation of QI and blood may bring about pain "; Or body YANG QI deficiency, cold from interior life, punching appoints uterus to lose in warm, affects QI-blood circulation.No matter be exogenous cold, endogenous cold, or excess-cold, deficiency and coldness, be usually mutual existence, interactional.Namely "Fu Qingzhu works on obstetric" has " cold-damp be pathogen also, the arteries and veins that married woman has punching to appoint occupy the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, through water by two through and go out, and cold-damp full two through and civil strike, two disaccord and make pain " discussion.

The cold visitor of morbidity polyphyly of cold coagulation blood addiction type dysmenorrhea rushes and appoints, and fights mutually with blood, so that uterus punching appoints QI and blood to lose freely, and then uterus QI and blood is appointed in premenstrual QI and blood bet punching in menstrual period, and Kui is stagnant more, stagnation of QI and blood may bring about pain, therefore primary disease cardinal symptom is premenstrual or cold-type pain in the lower abdomen during menstruation, pain alleviated while getting warmth; Complexion is bluish white, cold extremities with aversion to cold, resembles for one is cold; Menstruation or see postpones, and amount is few, through color dim and have addiction block or as decoction of black soybean sample be levying of addiction blood; The dim tongue of tongue is white, and deep-thready pulse or stringy and tense pulse are the time of cold coagulation blood addiction; And between non-menstrual period, because punching appoints QI and blood gentle, paathogenic factor is not enough to cause punching to appoint uterus QI and blood Kui stagnant or not enough, therefore at ordinary times not bitterly "

Dysmenorrhea is one of modal disease of gynecological, and its incidence rate report differs, and account for 42% ~ 90%, wherein severe pain is through accounting for 18%, nausea and vomiting can be accompanied, dripping cold sweat, deadly cold hand and foot time serious, very then faint, affect life and work more, unfavorable to the physical and mental health of women; But the treatment to dysmenorrhea, there is no desirable Therapeutic Method, western medical treatment, mainly to reduce prostaglandin in menstrual blood and symptomatic treatment, by using prostaglandin enzyme inhibitor, reduces prostaglandin (Prostaglandin, PG) generation, prevented strong or spastic uterine contraction, thus alleviate or eliminate pain, but its curative effect can not be lasting, thoroughly can not cure dysmenorrhea, and there is obvious drug side effect problem.The traditional Chinese medical science is controlled by integral syndrome differentiation opinion and is started with, and treatment dysmenorrhea demonstrates obvious advantage, has broad prospects.

Summary of the invention

Technical problem to be solved by this invention is, dysmenorrhea is a disease that is long-term, easily recurrent exerbation, can accompany nausea and vomiting, dripping cold sweat, deadly cold hand and foot, very then faint, affect life and work more time serious, totally unfavorable to the physical and mental health of women.In treatment, the appearance of PGSI, the sickness rate of this disease is greatly reduced, ibuprofen modified release capsule has stronger antiinflammatory, pain relieving, refrigeration function, by suppressing prostaglandin synthetase, thus suppresses the synthesis of prostaglandin, produce anti-inflammatory analgesic effect, therefore ibuprofen modified release capsule is premenstruum, and use has the effect prevented irritation, using menstrual period has spasmolytic, analgesic activity, is characterized in that administration is easy, instant effect.But because its symptom mainly for its pain is eased pain, improve not good to simultaneous phenomenon, thoroughly can not cure dysmenorrhea, and because of side effect larger, can cause nausea, vomit, the gastrointestinal upset such as diarrhoea, also can cause stomatitis, dizziness, tinnitus, blurred vision, the untoward reaction such as erythra, therefore still can not think that oral ibuprofen slow releasing capsule is the Perfected process for the treatment of dysmenorrhea.Chinese medicine is started with by entirety, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs demonstrates obvious advantage.For the addiction disorders of blood machine of dysmenorrhea, endocrine disturbance is main pathogeny, in conjunction with the modern pharmacological research achievement of Chinese medicine, explores traditional Chinese medical herbal treatment dysmenorrhea and has vast potential for future development.

For solving above-mentioned technical barrier, the invention provides a kind of Chinese medicine composition for the treatment of menorrhalgia of cold-stagnation and blood-stasis type, in Chinese medicine composition described in it, the parts by weight of the various crude drug of oral preparations are: 10 ~ 20 parts, Radix Rehmanniae Preparata, Herba Epimedii 10 ~ 20 parts, Fructus Foeniculi 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, in described Chinese medicine composition, the parts by weight of the various crude drug of external preparation are: Fructus Foeniculi 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, the Radix Linderae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Fructus Toosendan 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami.

The Chinese medicine composition of described treatment menorrhalgia of cold-stagnation and blood-stasis type, in Chinese medicine composition described in it, the parts by weight of the various crude drug of oral preparations can be: 10 ~ 15 parts, Radix Rehmanniae Preparata, Herba Epimedii 10 ~ 15 parts, Fructus Foeniculi 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Oletum Trogopterori 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, in described Chinese medicine composition, the parts by weight of the various crude drug of external preparation are: Fructus Foeniculi 10 ~ 15 parts, Fructus Cnidii 10 ~ 15 parts, Eupolyphaga Seu Steleophaga 10 ~ 15 parts, Radix Dipsaci 10 ~ 15 parts, Herba Asari 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, the Radix Linderae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Fructus Toosendan 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami.

The Chinese medicine composition of described treatment menorrhalgia of cold-stagnation and blood-stasis type, in Chinese medicine composition described in it, the parts by weight of the various crude drug of oral preparations can also be: 10 ~ 20 parts, Radix Rehmanniae Preparata, Herba Epimedii 10 ~ 20 parts, Fructus Foeniculi 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Myrrha 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, Radix Curcumae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Flos Campsis 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Rhizoma Sparganii 10 ~ 15 parts, in described Chinese medicine composition, the parts by weight of the various crude drug of external preparation are: Fructus Foeniculi 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, the Radix Linderae 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Ramulus Cinnamomi 10 ~ 15 parts, Folium Artemisiae Argyi 10 ~ 15 parts, Fructus Toosendan 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type, and when the oral preparations of Chinese medicine composition described in it is capsule, its preparation process is:

A, get all crude drug and put into water and soak, heat is extracted 2 times, is component 1;

B, the medicinal residues of said extracted being added ethanol extraction 2 times, is component 2;

C, by 2-in-1 and concentrated to component 1 and component; Be dried to powder tank encapsulated.

In described step a, can get all crude drug medicines steeps in water, adds in the water accounting for its quality 5-10 times amount and soaks 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, obtains component 1.

In described step b, the medicinal residues of crude drug medicine said extracted can crossed add ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, extractum is added the extraction into ethyl acetate secondary accounting for its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.

In described step c, can by above-mentioned two kinds extract extractum merge, when concentrating under reduced pressure relative density is 80 DEG C 1.35 extractum, reclaim ethanol, inserted in economic benefits and social benefits vacuum concentrator by above-mentioned two kinds of extracting solution, when being concentrated into 90 DEG C, relative density is the extractum of 1.60, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again and is condensed into extractum, is dried to powder tank encapsulated.

For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method for the treatment of the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type, and when the external preparation of Chinese medicine composition described in it is suppository, its preparation process is:

By described crude drug medicine except Folium Artemisiae Argyi, Fructus Foeniculi, Herba Asari and the Radix Linderae, all the other crude drug soak 1 to 2 hour, then heated and boiled 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into paste, then Folium Artemisiae Argyi, Fructus Foeniculi, Herba Asari and Radix Linderae steam distillation is extracted, and obtains crystal, is mixed in ointment obtained above; Choose substrate 50 DEG C ~ 60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet virus killing aftershaping.

Described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, and add the fine drug powder that preparation method described in claim 8 is obtained, stirring in water bath is even, be mixed into the liquid of thickness, be poured in plastic shape-forming pipe, insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described powder Chinese patent medicine and substrate is 1: 2 ~ 1: 4; Described tampon is the tampon of afterbody with cotton thread.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type, the preparation process when external preparation of described Chinese medicine composition is enema is: put into except Folium Artemisiae Argyi, the Radix Linderae, Herba Asari and Fructus Foeniculi by described crude drug after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 30%, collects by the crude drug fine powder of 100 mesh sieves for subsequent use; Again the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; In described steps d, crystallization of Folium Artemisiae Argyi, the Radix Linderae, Herba Asari and Fructus Foeniculi distillation being vaporized to obtain, is dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.46, stir evenly after adding the crystalline powder of fine powder and the distillation of sieving, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.50 extractum, heating be condensed into pasty state, ultraviolet virus killing after use.

External preparation of the present invention uses in menstruation complete 2nd day coloclysis or makes suppository puts into intravaginal, is used in conjunction 15 days once a day.

The technique effect that the present invention is useful is, the present invention can only be eased pain to the symptom of dysmenorrhea pain mainly for Western medicine, to simultaneous phenomenon improve not good, thoroughly can not cure dysmenorrhea, and because of side effect larger, can cause nausea, vomit, the gastrointestinal upset such as diarrhoea, also can cause stomatitis, dizziness, tinnitus, blurred vision, the untoward reaction such as erythra, Chinese medicine is started with by entirety, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs demonstrates obvious advantage.For the addiction disorders of blood machine of dysmenorrhea, endocrine disturbance is main pathogeny, in conjunction with the modern pharmacological research achievement of Chinese medicine, explores traditional Chinese medical herbal treatment dysmenorrhea and has vast potential for future development.The present invention has dual regulation to uterus, (namely cause excitation-contraction when uterus shows as in normal state, then cause lax when uterus is in spasticity) and improve circulation, the effect of enhancing body cellular immune function, reaches and promotes that endometrium comes off and repairs, and contributes to the phase of recovering menstruation, amount, color, matter, clinical treatment dysmenorrhea reaches the object for the treatment of must aim at the pathogenesis of disease.

Detailed description of the invention

About dysmenorrhea, motherland's medical science has the record such as " menalgia ", " hanging pain over the perineum ", " through the lower cattle diaphragm of row ".All there is periodically lower abdomen pain women on the occasion of menstrual period or front and back of passing through in ancient Chinese medicine doctor, or pain draws waist sacrum, and very then severe pain is fainted, and is called dysmenorrhea.

Dysmenorrhea one sees the earliest " Medical Treasures of the Golden Chamber the miscellaneous internal diseases in woman arteries and veins disease is also controlled " " leukorrhagia, menstrual disorders, lower abdominal pain and fullness.Through goodbye in January." " General Treatise on the Cause and Symptoms of Diseases " cloud: " married woman's menstrual abdominalgia person, by impairment caused by overstrain vim and vigour, so that body is empty, by air-cooled gas visitor in collaterals of the uterus, fights with mutually with vim and vigour, therefore order pain is also ", and first vertical " menstrual abdominalgia time " they are research and treatment dysmenorrhea based theoretical.

About the etiology and pathogenesis of dysmenorrhea, ancients describe a lot of.Roughly there are three kinds of views: one, cause a disease because of the body void air-cooled heresy of impression.As front " General Treatise on the Cause and Symptoms of Diseases " namely proposes this viewpoint.In addition " Complete Effective Prescriptions for Women's regulating menstruation Men Yueshui go no go trusted subordinate twinge side opinion ": " Mr. and Mrs' man month menalgia person, by impairment caused by overstrain QI and blood, causes and make body empty; Air-cooled gas visitor, in collaterals of the uterus, damages the arteries and veins of appointing in punching, the warp of the hands sun, few the moon.Chong channel, conception vessel all arise from uterus, for sea of channels also.Therefore when water will go the moon, vim and vigour are moved in air-cooled, air-cooledly to hit mutually with QI and blood.Therefore order pain." " Chao Shi cause of disease " also say: " woman enter menstrual abdominalgia person, caused by the sub-collaterals of the uterus of air-cooled gas visitor ".

About the etiology and pathogenesis of dysmenorrhea, it is relevant with physiological environment special before and after ferritic and menstrual period, menstrual period that modern Chinese medicine thinks that it occurs.Between non-menstrual period, punching appoints QI and blood gentle, and paathogenic factor can not cause that punching is appointed, rich the stasis of blood is stagnant or not enough for born of the same parents, therefore pain does not occur, and before and after menstrual period or menstrual period, the sea of blood rushes down excessive by being completely full of, uterus QI and blood by arrogant blood prosperous to through after temporarily empty, QI and blood change is anxious to gather, paathogenic factor is taken the opportunity and does, make QI-blood circulation not smooth, born of the same parents are rich, and menses circulation is obstructed, so that stagnation of QI and blood may bring about pain; Or cause punching appoint a uterus lose in moisten support not flourish and pain.Take a broad view of many doctor's documents, all unanimously think that the basic pathogenesis of dysmenorrhea is " stagnation of QI and blood may bring about pain ", " not Rong Ze pain ".

Dysmenorrhea refer to women pass through before and after or menstrual phase there is hypogastralgia, falling inflation, companion's soreness of waist or other are uncomfortable, degree has a strong impact on live and work quality person.Dysmenorrhea can be divided into primary dysmenorrhea and secondary dysmenorrhea.Primary dysmenorrhea refers to the dysmenorrhea of genitals without obvious pathological changes; Secondary dysmenorrhea refers to the dysmenorrhea caused by pelvic cavity organic disease, is mainly seen in endometriosis and adenomyosis, and the two is all the disease that ectopic endometrium causes.The sampling survey of whole nation woman in menstrual period physiology investigation cooperative groups shows, in China women, the incidence rate of dysmenorrhea is 33.1%, and wherein primary dysmenorrhea accounts for 53.2%.Primary dysmenorrhea is one of common psychosomatic disease of gynecological, because its higher sickness rate causes the concern of people; Endometriosis and adenomyosis in recent years sickness rate are also more and more higher, have caused the common concern of Chinese scholars.But the cause of disease of gynecopathy and gland myopathy and pathogenesis are all not yet completely clear, control is got up more difficult.

Recent domestic scholar starts to grind from EPDML angle to get to the bottom of sb.'s illness, to find the measure of effective treatment and prevention dysmenorrhea.Epidemiology thinks that primary dysmenorrhea is more common in 15-25 year unmarried female, is one of common symptom of adolescence, and has certain hereditary basis; Age of menarche in advance, unhealthy emotion, Bad Eating Habit, the sleep such as depressed and anxiety less, smoking, drink, hyperkinesia is its risk factor; Full-term pregnancy childbirth, Sufficient Sleeping and modest movement are then protection factor.Gynecopathy is apt to occur in 25-45 year women at fertile age, and it has certain hereditary basis; Menarche time advance, cycle time, menostaxis and menorrhagia, dysmenorrhea, motion in menstrual period, heavy burden, sexual intercourse, artificial abortion, places the operations on pelvis such as IUD, dioxin, autoimmune disease history, stature is weedy, too much takes in caffeine, pungent diet, operating pressure is large, and schooling is high, unhealthy emotion, A blood group, endocrine regulation history of disease etc. is the risk factor of endometriosis; Full-term pregnancy, oral contraceptive, smoking etc. are protection factor.Adenomyosis is apt to occur in the multipara of more than 40 years old, and high estrogen level, fecund, repeatedly artificial abortion's dilatation and curettage of uterine history, reproductive tract block for its risk factor.

About dysmenorrhea, motherland's medical science has the record such as " menalgia ", " hanging pain over the perineum ", " through the lower cattle diaphragm of row ".Or cause because of the body void air-cooled heresy of impression; Or for the stagnation of QI or blood stasis cause stasis and pain; And the heresy of cold-damp causes.Etiological pathogenesis is " stagnation of QI and blood may bring about pain " " not Rong Ze pain ".Most report thinks that dysmenorrhea is common has qi depression to blood stasis, cold blood stasis, dampness and heat stasis, deficiency of both QI and blood regulating liver-QI to suffer from a deficiency of the kidney damage five pattern of syndrome.

Radix Paeoniae Rubra is cool in nature, and bitter in the mouth acid, is slightly cold, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving.Yin fluid astringing receives the effects such as antiperspirant, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.Paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Rubra decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.The condition subject such as the blood deficiency deficiency of YIN, the breast abdomen pain over the hypochondriac region, pain in the hepatic region, cholecystitis, gallstone pain, dysentery stomachache, women's menalgia, spontaneous perspiration easy antiperspirant night sweat, sural spasm, spasm of the limbs pain, uneasy lower limb syndrome are suitable edible.

Herba Epimedii herb hyoscine.Cure mainly impotence and premature ejaculation, pain in the low back and legs, numb limbs and tense tendons, hemiplegia, neurasthenia, forgetful, tinnitus, dizzy disease such as grade.Herba Epimedii is Chinese conventional Chinese medicine.Kidney invigorating and YANG supporting, expelling wind and removing dampness.Control sexual impotence erectile problem, hemiplegia is unsuccessful, dribbling urination, and muscles and bones contraction is anxious, and cough, optic atrohic blindness after being ill, toothache caused by fire of deficiency type, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless." herbal classic ": main impotence is hindered absolutely, pains in the penis.Diuresis, physical strength profiting, Qiang Zhi." not Lu ": hard muscles and bones.Disappear scrofula, red carbuncle; Skin ulcer is arranged at bottom, washes, and goes out worm." Japan hanako materia medica ": control all cold wind consumptive disease, mend waist knee joint, heart tonifying power, husband is exhausted, and sun does not rise, the exhausted cloudy loss of fecundity of woman, and muscles and bones contraction is anxious, and extremity are not appointed, and old man's dusk octogenarian, the middle age is forgetful.

Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.Herba Leonuri, containing the material such as leonurine, Fumaric acid, has the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.External is gynecological's good medicine of activating blood circulation to dissipate blood stasis.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

The Radix Astragali has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, and food stagnation is stagnated, carbuncle from the beginning of or the excess syndrome such as pyretic toxicity Shang Sheng after bursting.The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst." herbal classic " is recorded: " main carbuncle, loses skin ulcer for a long time, evacuation of pus pain relieving.Tonify deficiency, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas strengthening bone and muscle, put on flesh and enrich blood.”

The current domestic Dragon Blood of Sanguis Draxonis mostly is Liliaceae Dracaena cochinchinensis or dracaena cambodiana Pierre resin.Foreign resina draconis is comparatively rare.Yunnan Folium Dracaenae cambodianae is damaged rear flowed out myron can make Sanguis Draxonis through processing.Effect takes promoting blood circulation to remove blood stasis orally, analgesic therapy, external hemostasia and promoting granulation, sore.Cure mainly 1. congestion amenorrhea, dysmenorrhea, postpartum stagnation.2. lump in the abdomen mass in the abdomen, breast ventral spine pain.3. traumatic injury, congestion swells and ache.4. traumatic hemorrhage, ulcer being unable to heal.

Radix Curcumae is the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y.H.Chen et C.Ling, Rhizoma Curcumae Longae Curcuma longaL..The above two practise title " RADIX CURCUMAE " and " Radix Curcuma " respectively, and all the other are practised by character difference and claim " osmanthus Radix Curcumae " or " green filament Radix Curcumae ".Winter, stem and leaf was excavated after withering, and removing silt and radicula, steam or boil to the saturating heart, dry.Nature and flavor with return through: pungent, bitter, cold.Return liver, the heart, lung meridian.Function cures mainly: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, and clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.

A kind of Chinese medicine material of Flos Campsis, has promoting the circulation of blood blood stasis removing, cooling blood, expelling wind dampness removing, heat-clearing and toxic substances removing, and acrid in the mouth acid, cold nature returns liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly menoxenia, amenorrhea lump in the abdomen, puerperal swelling of the breast, skin pruritus. " Amplification on Materia Medica addendum ": Flos Campsis, control the key medicine of pain in blood also, and nourishing YIN victory very, is stamped and keeps and walk alone, in married woman side multiplex what." Nanning City's medicine will ": the merit having eliminating inflammation and expelling toxin, hemostasis and pain-relieving, evacuation of pus granulation promoting, controls red Hakuri.

Rhizoma Cyperi is regulated the flow of vital energy resolving depression; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang ex Z.Y.Su et C.Y.Wu), Papaveraceae, Corydalis perennial herb, another name: Rhizoma Corydalis, corydalis tuber, rhizoma corydalis, Rhizoma Corydalis.Chinese tradition medical material.Mainly originate in Zhejiang and Jiangsu.Its tuber (Rhizoma Corydalis Decumbentis), containing the multiple alkaloid such as corydaline, protopine, through making powder or fluid-acet-extract etc., cures mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.There are analgesia, calmness, syngignoscism.

Rhizoma Chuanxiong enters liver, spleen, three burnt three warps.Function cures mainly activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." detailed outline " carries: " dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine removes vascular smooth muscle (aortic article) spasm (epinephrine, potassium chloride cause).Can also coronary vasodilator be expanded, increase coronary flow.The myocardial ischemia-anoxemia that antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that ligation arteria coronaria causes.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Rhizoma Sparganii has another name called belt leather Rhizoma Sparganii.For the dry tuber of Sparganiaceae plant rhizoma scirpi Sparganiuum stoloniferumBuch.-Ham..Above all with matter heavily fortified point, body weight, drying, remove crust, surperficial yellow-white person for good.Swollen pain, amenorrhea, postnatal blood stasis stomachache, traumatic injury, skin ulcer swell hard down to control lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the side of body.Lump in the abdomen controlled by Chinese medicine, gathers, distending pain over the hypochondrium, food stagnation distending pain, dysmenorrhea, amenorrhea, and postnatal blood stasis is suffered from abdominal pain, traumatic injury.Cough due to lung-heat controlled by mongolian medicine, asthma abundant expectoration, liver-heat, arteries and veins heat, the hot hectic fever due to YIN-deficiency of consumptive disease, and " precious day " is sick, fracture.

Radix Rehmanniae Preparata is scrophulariaceae rehmannia glutinosa plant, formal name used at school: the tuber of Rehmannia glutinosa, has another name called Radix Rehmanniae Preparata or throws oneself on the ground, forming through Processing methods.Usually with wine, Fructus Amomi, Pericarpium Citri Reticulatae for adjuvant is through repeatedly steaming solarization, to inside and outside darkish complexion glossy, quality softness is sticky.Section use, or parch to black is used.Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese crude drug, there is YIN nourishing effect of enriching blood, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also diseases such as can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, pass out semen, quench one's thirst is one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.

Fructus Foeniculi is the dry mature fruit of samphire Fructus Foeniculi FoeniculumvulgareMill..You Ming Huai perfume (or spice) " the fragrant son " Newly Revised Canon of Materia Medica " of property of medicine opinion 》， Huai, dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach.Invigorate blood circulation, promoting the circulation of QI, pain relieving.For Xiong Xie institute abdomen pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.For colic of cold type stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhea, few abdomen cold type of pain, abdominal distention, lack of appetite and vomiting, hydrocele of testis.Salt Fructus Foeniculi warming the kidney dispersing cold for relieving pain.

Oletum Trogopterori: Oletum Trogopterori is the feces of Mammalia, flying squirrel section animal trogopterus xanthipes Milne-Edwards (cold number bird), flying squirrel or other nearly edge animal." Oletum Trogopterori " is homophonic with " lipoid " two words.Li Shizhen (1518-1593 A.D.) is released its name and is said: " its excrement name Oletum Trogopterori person, meaning shape as lipoid by the gas of the five elements also ".Oletum Trogopterori is sweet in flavor and warm in property, nontoxic, enters Liver Channel, has dredging blood vessel, effect of eliminating stasis to stop pain; It is gynecological's key medicine.Oletum Trogopterori compatibility Rhizoma Cyperi: Oletum Trogopterori activating blood and removing stasis pain relieving; The pain relieving of Rhizoma Cyperi depressed liver-energy dispersing and QI regulating. Papillary has depressed liver-energy dispersing and QI regulating, effect of promoting blood circulation and stopping pain is used for the treatment of hyperactive liver-QI attacking the stomach side of body rib, gastralgia.

Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension." Bencao Jingshu ": Herba Taxilli, its bitter but sweet flavor, its gas is gentle, cold not hot, admittedly should be nontoxic.It cures mainly in detail, take out its elite for one, therefore function compares Sang Yousheng in Mulberry.Lumbago and children's's stiffback, all time of insufficiency of blood, carbuncle is many due to ying-qi heat.Skin does not fill, due to blood deficiency.Tooth person, originator, beneficial blood then sends out China after blood also, and the sufficient then tooth of kidney qi is hard and an eyebrow is long after bone also.Blood contains then tire peace certainly.Woman's metrorrhagia and internal injury deficiency, all events of blood deficiency interior-heat.Disease more than puerperal, all by blood system, agalactia, also by blood deficiency.Incised wound is then hindered entirely in blood.To come up all diseases, there's no one who doesn't or isn't know and have heat institute to send out by blood deficiency, this property of medicine can beneficial blood, thus also lead also.Hold concurrently and can wet by core, therefore also treat numbness.

Cortex Moutan and Cortex Moutan, Chinese medicine name.For the dry root bark of ranunculaceae peony.Originate in the ground such as Anhui, Sichuan, Henan, Shandong.There is effect of clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis, reducing the asthenic fever.Clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Beriberoid pyretic arthralgia.Control blood deficiency overstrain dysphoria with feverish sensation in the chest palms and soles limbs pain head dusk center of gravity alarmed and panicky cheek red dryness of the mouth and throat heating night sweat to subtract food drowsiness and heat in blood and to fight mutually unsmooth menorrhea umbilicus abdominal distention and pain fever and chills similar to malaria; Control again unmarried girl's blood weak deficiency of YIN Rong Wei discord phlegmatic cough hectic fever human body weakness and emaciation." herbal classic ": " main cold and heat, apoplexy Chi Zong, convulsion, infantile convulsion pathogen, except the hard blood stasis of disease stays house the intestines and stomach, settling five organs, treat carbuncle skin ulcer."

Cortex Cinnamomi complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower." herbal classic ": Your Majesty's gas cough with dyspnea, stagnation of QI sore throat tells suction, sharp joint, invigorating the spleen and replenishing QI." not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago, only saliva, cough ， Bi Weng: can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, without feared.

Fructus Rubi plant can be used as medicine, and has multi-medicament to be worth, and its fruit has the effect of kidney invigorating and YANG supporting.Raspberry seed oil belongs to unsaturated fatty acid, can promote that the severe that of prostatic secretions covers.Effect: the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight.Make observation index with the vaginal smear of rat, rabbit and inner membrance section, Fructus Rubi seemingly has estrogen-like effects.Bacteriostasis 100% decoct flat board burrows method, has inhibitory action, also have inhibitory action to vibrio cholera to staphylococcus.The indexs such as the vaginal smear of estrogen-like effects rat, rabbit and inner membrance section show, Fructus Rubi seemingly has estrogen-like effects.

External:

Herba Patriniae nature and flavor hardship is flat, has effect of heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain can be cured.Enter stomach, large intestine, Liver Channel.Cure mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.

Fructus Toosendan is cold in nature, bitter in the mouth, is the one of qi-activating drug.Mainly enter Liver Channel, catharsis liver-heat, promoting the circulation of QI to relieve pain, have the function except damp and hot, clearing away liver-fire, pain relieving, parasite killing.Function cures mainly soothing liver-QI, promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation." herbal classic ": " main temperature disease, typhoid fever are too hot tired mad, kill three scabies and steal, diuresis water channel

Radix Dipsaci, Chinese medicine name.Having another name called shaven head, is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, gains the name because of energy " synthetism of continuous folding ".Autumn excavates, and removing root head and fibrous root, be dried to half-dried with low baking temperature, when bank up " diaphoresis " is to inner virescence, then dries." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians determine in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, and antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”

Folium Artemisiae Argyi is the dried leaves of feverfew Chinese mugwort Artemisia argyi Levl.et Vant..Most of China area is all produced.Be good with Hubei Qi Zhou (local of Li Shizhen (1518-1593 A.D.)) product person, claim " Artemisia argyi Levl. et Van. var. argyi cv. Qiai ", because it obtains rustic suitable, leaf is thick and floss is many, and as the material of moxibustion treatment, power is maximum.Pluck when summer, flower was not opened, removing impurity, dries or dries in the shade.Folium Artemisiae Argyi acrid in the mouth, hardship, warm in nature, there is warming the meridian for stopping bleeding, dispersing cold for relieving pain, effect of wet down parasite killing.Folium Artemisiae Argyi acrid in the mouth, hardship, warm in nature, nontoxic; Return spleen, liver, kidney channel; Fragrance temperature is loose, can rise to fall to have warming the meridian for stopping bleeding, dispersing cold for relieving pain, and effect of wet down parasite killing, cures mainly menoxenia, dysmenorrhea, infertility, frequent fetal movement, trusted subordinate's cold type of pain, spits blood, epistaxis, and spitting of blood, has blood in stool, metrorrhagia, gestation hemorrhage, chronic dysentery of having loose bowels, leukorrhagia, eczema, scabies, carbuncle, hemorrhoid.Moxibustion treatment all kinds of diseases and ailments.

Flos Carthami, another name: red indigo plant flower thorn Flos Carthami, Latin literary fame: Carthamus tinctorius L. Compositae, Flos Carthami platymiscium, dry tubular flower, is about 1.5 centimetres, orange red, floral tube is carefully narrow, and tip 5 splits, and sliver is narrow linear, long 5 ~ 8 millimeters, 5 pieces, stamen, flower pesticide is yellow, is unified into pipe, exceed outside sliver, its central authorities have stigma to expose.The special fragrance of tool, mildly bitter flavor.To spend, length of a film, color are scarlet, the soft person of matter is good.The ground such as main product Henan, Hunan, Zhejiang, Sichuan.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, swells and ache for amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, traumatic injury, skin infection.Have blood circulation promoting and blood stasis dispelling, wet dissipation goes the effect swollen, but anemia of pregnant woman will be avoided to use, otherwise can cause miscarriage.Flos Carthami can be used for foot bath, contributes to accelerating foot's blood circulation.

Fructus Cnidii (Cnidium monnieri (L.) Cuss.), Herba Clinopodii megalanthi just by name, another name Daucus carota L. is the dry mature fruit of samphire cnidium monnieri.Gather when summer, autumn two season fruit maturation, removing impurity, dries.Nature and flavor: warm in nature, acrid in the mouth, hardship.Function cures mainly: warming the kidney to invigorate YANG, and dampness is dispeled the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.

The Radix Linderae has pharmacologically active comparatively widely, mainly as follows:

1, the excitation of volatile oil: time for oral administration, have excited corticocerebral effect, and have promotion to breathe, excited cardiac muscle, accelerates blood circulation, the effect of raising blood pressure and diaphoresis.Local topical makes local vascular dilation, and blood circulation accelerates, and relaxes muscle spasm pain.2, bacteriostasis: to staphylococcus aureus, α-hemolytic streptococcus, Bacillus typhi, Bacillus proteus, bacillus pyocyaneus, escherichia coli all have inhibitory action.3, on gastral impact: have the report Radix Linderae to have dual function to gastrointestinal smooth muscle, in addition, the Radix Linderae can increase the secretion of Digestive system.4, anastalsis: experiment in vitro proves, Radix Linderae dry powder can obviously shorten plasma in rabbit recalcification time, promotes blood clotting and good anastalsis.5, other effect: feed rat for a long time with the Radix Linderae, body weight can be made to increase, and have inhibitory action to murine sarcoma-180.Its Borneolum Syntheticum can diaphoresis, excitement, spasmolytic, anthelmintic etc.

Herba Asari (formal name used at school: Asarum sieboldii Miq.), has another name called: magnificent Herba Asari, little Xin, few pungent, careless Herba Asari of basin etc., belong to Aristolochiales, Aristolochiaceae perennial herb; Root stock upright or horizontal walk, have many fibrous roots; Usual 2 pieces of leaf, blade is heart-shaped or ovum shape is heart-shaped, flower atropurpureus; Long 2 ~ the 4cm of bennet; Perianth sliver triangular shape is avette, and fruit is closely spherical, and diameter is about 1.5cm, brown color.4 ~ May of florescence.Cure mainly: dispel the wind, cold expelling, row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.Herba Asari can outer dispersing wind and cold, again can in dispel YIN-cold, pain relieving simultaneously, antitussive effect are better.

Eupolyphaga Seu Steleophaga has effect of removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.Pharmacological evaluation, has the effect of dispersing swelling and dissipating binds.Cure mainly blood stasis etc. in traumatic injury, abdomen.Containing volatile oil and aminoacid.Volatile oil total amount about 22%, is mainly naphthalene, fatty aldehyde, aromatic aldehyde; Total amino acid content about 40%.Pharmacology can make hematocrit, whole blood high shear viscosity, whole blood low shear viscosity, erythrocyte aggregation index, erythrocyte mechanical fragility all reduce, and makes erythrocyte sedimentation rate, erythrocyte sedimentation rate constant obviously raises.In addition effects such as also having blood fat reducing, anoxia enduring, ease pain, resist myocardial ischemia.

Its nature and flavor of Ramulus Cinnamomi are pungent, sweet, temperature, enter lung, the heart, urinary bladder channel, cure mainly the conventional drugs for dispelling internal cold of interior cold, there is effect of complement sun, promoting blood circulation, warming the spleen and stomach, normal with invigorating the liver and kidney medicine, fill blood medicine compatibility, treats insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, treat coldness and pain in the epigastrium, arthralgia due to cold lumbago with other drugs for dispelling internal cold compatibility, there is the effect of significantly analgesia and anti-cancer and cancer-preventing.Existing various wind dispelling oils medicine is if menthocamphorate, rheumatism wet goods are all containing cassia oil composition.Cure mainly " Sullfortrone " leprous its main component and cassia oil, other side-product of Cortex Cinnamomi has different pharmacological actions as Ramulus Cinnamomi, Fructus cinnamomi japonici, Fructus cinnamomi immaturus, osmanthus cup etc., widely applies in Chinese medicine.

Specific embodiment 1: the preparation of Tablets agent

Get crude drug Radix Rehmanniae Preparata 1000g, Herba Epimedii 1000g, Fructus Foeniculi 1000g, Radix Angelicae Sinensis 1000g, Herba Leonuri 1000g, Oletum Trogopterori 1000g, Radix Astragali 1000g, Herba Taxilli 1000g, Cortex Moutan 1000g, Cortex Cinnamomi 1000g, Fructus Rubi 1000g, Myrrha 1000g, Sanguis Draxonis 1000g, Radix Curcumae 1000g, Radix Paeoniae Rubra 1000g, Flos Campsis 1000g, Rhizoma Cyperi 1000g, Rhizoma Corydalis 1000g, Radix Salviae Miltiorrhizae 1000g, Rhizoma Chuanxiong 1000g, Caulis Spatholobi 1000g, Rhizoma Sparganii 1000g, getting all crude drug medicines steeps in water, soak more than 2 hours, add 8 times amount accounting for crude drug medicine gross mass respectively, the water extraction of 6 times amount 2 times, extraction time is 2 hours, 1 hour, merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.The medicinal residues of crude drug medicine said extracted crossed add ethanol, and add the ethanol warm macerating 2 times of 10 times amount of medicinal residues gross weight, 8 times amount respectively, the warm macerating time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm macerating liquid; Warm macerating liquid is evaporated to 1.25 extractum when density is 60 DEG C, and extractum is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.By also 2-in-1 to component 1 and component, when concentrating under reduced pressure relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, inserted in economic benefits and social benefits vacuum concentrator by above-mentioned two kinds of extracting solution, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.60, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again and is condensed into extractum, adds starch and is in harmonious proportion, tabletting after ultraviolet radiation for sterilizing and disinfecting.

Specific embodiment 2: the preparation of capsule of the present invention

Get crude drug Radix Rehmanniae Preparata 1200g, Herba Epimedii 1200g, Fructus Foeniculi 1300g, Radix Angelicae Sinensis 1200g, Herba Leonuri 1200g, Oletum Trogopterori 1200g, Radix Astragali 1100g, Herba Taxilli 1200g, Cortex Moutan 1200g, Cortex Cinnamomi 1300g, Fructus Rubi 1200g, Myrrha 1200g, Sanguis Draxonis 1200g, Radix Curcumae 1200g, Radix Paeoniae Rubra 1200g, Flos Campsis 1100g, Rhizoma Cyperi 1200g, Rhizoma Corydalis 1200g, Radix Salviae Miltiorrhizae 1200g, Rhizoma Chuanxiong 1300g, Caulis Spatholobi 1200g, Rhizoma Sparganii 1200g, get crude drug medicine clean dry, in 70 DEG C of baking ovens, dry 1-3h, taking-up is placed in cooling in drying baker, 80-100 mesh sieve was pulverized with pulverizer.By for subsequent use for the fine powder sieved, unsifted coarse granule one bubbles in ethanol after 1-2 days, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2g crude drug amount, is then dried to powder, adds the fine powder sieved, ultraviolet disinfection, canned capsule.

Specific embodiment 3: the preparation of oral liquid of the present invention

Get crude drug Radix Rehmanniae Preparata 1300g, Herba Epimedii 1200g, Fructus Foeniculi 1300g, Radix Angelicae Sinensis 1300g, Herba Leonuri 1200g, Oletum Trogopterori 1200g, Radix Astragali 1100g, Herba Taxilli 1200g, Cortex Moutan 1300g, Cortex Cinnamomi 1200g, Fructus Rubi 1200g, Myrrha 1200g, Sanguis Draxonis 1200g, Radix Curcumae 1300g, Radix Paeoniae Rubra 1200g, Flos Campsis 1100g, Rhizoma Cyperi 1200g, Rhizoma Corydalis 1200g, Radix Salviae Miltiorrhizae 1200g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1300g, Rhizoma Sparganii 1200g, be mixed and put into acid and alkali-resistance infusion kettle, at room temperature, 3 ~ 7 days are flooded together with more than 70 degree ethanol, then heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, filter, filtrate is got after separation, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge lixiviating solution, being condensed into pasty state becomes component 2, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the extractum of 1.60, add Mel be in harmonious proportion after ultraviolet sterilization fill.

Specific embodiment 4: the preparation of pill of the present invention

Get crude drug Radix Rehmanniae Preparata 1300g, Herba Epimedii 1200g, Fructus Foeniculi 1300g, Radix Angelicae Sinensis 1300g, Herba Leonuri 1200g, Oletum Trogopterori 1200g, Radix Astragali 1100g, Herba Taxilli 1200g, Cortex Moutan 1300g, Cortex Cinnamomi 1200g, Fructus Rubi 1200g, Myrrha 1200g, Sanguis Draxonis 1200g, Radix Curcumae 1300g, Radix Paeoniae Rubra 1200g, Flos Campsis 1100g, Rhizoma Cyperi 1200g, Rhizoma Corydalis 1200g, Radix Salviae Miltiorrhizae 1200g, Rhizoma Chuanxiong 1200g, Caulis Spatholobi 1300g, Rhizoma Sparganii 1200g; Getting all crude drug medicines steeps in water, soaks more than 2 hours, add respectively account for crude drug medicine gross mass 8 times amount, 6 times amount water extraction 2 times, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.The medicinal residues of crude drug medicine said extracted crossed add ethanol, and add the ethanol warm macerating 2 times of 10 times amount of medicinal residues gross weight, 8 times amount respectively, the warm macerating time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm macerating liquid; Warm macerating liquid is evaporated to 1.25 extractum when density is 60 DEG C, and extractum is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.Extract extractum by above-mentioned 4 times to merge, when concentrating under reduced pressure relative density is 80 DEG C 1.28 pasty state, reclaim ethanol, gained pasty state is passed into spray dryer and carries out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 80 DEG C, obtains crude drug medicated powder; Add Mel and be twisted into pill.

Specific embodiment 5: the preparation of external enema of the present invention

By described crude drug Fructus Cnidii 1500g, Eupolyphaga Seu Steleophaga 1500g, Radix Dipsaci 1500g, Radix Salviae Miltiorrhizae 1500g, Herba Patriniae 1500g, Ramulus Cinnamomi 1500g, Fructus Toosendan 1500g, Flos Carthami 1500g; Put into after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 30%, collects by the crude drug fine powder of 100 mesh sieves for subsequent use; The particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution is merged and leaves standstill; The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; In described steps d, Folium Artemisiae Argyi 1500g, Fructus Foeniculi 1500g and Radix Linderae 1500g, Herba Asari 1500g are distilled crystallization of vaporizing to obtain, is dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.46, stir evenly after adding the crystalline powder of fine powder and the distillation of sieving, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.50 extractum, heating be condensed into pasty state, ultraviolet virus killing after use.

Specific embodiment 6: preparation process when external preparation of the present invention is suppository is:

By described crude drug medicine Fructus Cnidii 1500g, Eupolyphaga Seu Steleophaga 1500g, Radix Dipsaci 1500g, Radix Salviae Miltiorrhizae 1500g, Herba Patriniae 1500g, Ramulus Cinnamomi 1500g, Fructus Toosendan 1500g, Flos Carthami 1500g, soak 1 to 2 hour, then heated and boiled 30 ~ 40 minutes, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into paste, then Folium Artemisiae Argyi 1500g, Fructus Foeniculi 1500g, Herba Asari 1500g and Radix Linderae 1500g steam distillation is extracted, and obtains crystal, is mixed in ointment obtained above; Choose substrate 50 DEG C ~ 60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet virus killing aftershaping.Described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, adds the fine drug powder that described preparation method is obtained, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described powder Chinese patent medicine and substrate is 1: 2 ~ 1: 4; Described tampon is the tampon of afterbody with cotton thread.

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of white mice, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicated powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicated powder dosage is > 42g/kg. day (every g medicated powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with matched group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safety range of the present invention is comparatively large, is a kind of safe and reliable health product.

Pharmacological experiment:

Dysmenorrhea is that the classical symptom of endometriosis is taken out ".Mostly be secondary dysmenorrhea, increase the weight of in Progressive symmetric erythrokeratodermia.Pain multidigit is in hypogastric region and lumbosacral region.Vagina, perineum, anus or thigh can be radiated to, often in first 1.2 days of menstrual onset, whole menstrual phase can be run through.The degree of pain is not necessarily directly proportional to size of tumor, and relevant with the position of focus and intramural invasion, occasionally has periodic abdominalgia to occur person asynchronous with menstruation a little later.During Rupture of Ovarian Endometrioma, sudden tormina can be caused, companion's Nausea and vomiting and rectal tenesmus.Pain mostly occurs before and after menstrual phase or its, the similar rupture of tubal pregnancy of symptom.When other any positions of health have Endometriosis to plant and grow, the cycle lives pain, hemorrhage or swollen thing increases all position can be handed over to occur in disease.Dysmenorrhea is one of modal disease of gynecological, and its incidence rate report differs, and account for 42% ~ 90%, wherein severe pain is through accounting for 18%, nausea and vomiting can be accompanied, dripping cold sweat, deadly cold hand and foot time serious, very then faint, affect life and work more, unfavorable to the physical and mental health of women; But the treatment to dysmenorrhea, there is no desirable Therapeutic Method, western medical treatment, mainly to reduce prostaglandin in menstrual blood and symptomatic treatment, by using prostaglandin enzyme inhibitor, reduces prostaglandin (Prostaglandin, PG) generation, prevented strong or spastic uterine contraction, thus alleviate or eliminate pain, but its curative effect can not be lasting, thoroughly can not cure dysmenorrhea, and there is obvious drug side effect problem.The traditional Chinese medical science is controlled by integral syndrome differentiation opinion and is started with, and treatment dysmenorrhea demonstrates obvious advantage, has broad prospects.

The traditional Chinese medical science thinks that dysmenorrhea is the disease of long-term, an easily recurrence, and menstrual period or puerperal experience cold-evil, or the cold and cool raw food of surfeit, and prolonged illness enters the reasons such as bloodization is tired can cause dysmenorrhea, common with syndrome of qi stagnation and blood stasis clinically, disease sees premenstrual inferior belly gas pain, acute through row pain, pain draws waist sacrum, and pain is very fainted, abdominal pain with tenderness; Blockage of menstruation, has held clot under the arm, alleviation of pain under block; Rectal tenesmus; Premenstrual distending pain of the breast, does not uncomfortable in chestly relax; Dyspareunia; Purplish tongue is dim, limit is sharp has ecchymosis, white and thin fur, stringy pulse.

This research, by taking ibuprofen modified release capsule as matched group, inquires into the Clinical efficacy and safety that the present invention treats menorrhalgia of cold-stagnation and blood-stasis type.

Clinical data

(1) physical data

1.1 case sources

Case group patient is all from attached east hospital of Shandong Traditional Chinese Medicine University, the People's Hospital's Out-patient Clinic of Department of Gynecology and inpatient.Dysmenorrhea patient 120 example is collected altogether year March from December, 2011 to 2012.

Matched group derives from the attached east hospital of Shandong medical pharmaceutical university, the People's Hospital of city Out-patient Clinic of Department of Gynecology goes to a doctor patient.84 examples are collected altogether year March from December, 2011 to 2012.

1.2 ordinary circumstance

1.2.1 case group

120 routine dysmenorrhea patient ages 14 ~ 45 years old, average 27.86 ± 6.84 years old; Married 65 examples (54.17%), unmarried 54 examples (45%), divorced l example (0.83%).Primary dysmenorrhea (PD) patient 80 example, secondary dysmenorrhea (SD comprises endometriosis, adenomyosis) patient 40 example; Simple gynecopathy patient 2l example in secondary dysmenorrhea patient, simple gland patients with myopathy 12 example, gynecopathy merges gland patients with myopathy 7 example; Through clinical diagnosis person 26 example, the operation person of making a definite diagnosis 14 example, wherein postoperative recurrence person is 6 examples.All patients carry out classification and scoring according to its dysmenorrhea symptom, are divided into slight 20 examples, moderate 65 example, severe 35 example.

Infertile person 13 example is merged in 120 routine dysmenorrhea patients, all from secondary dysmenorrhea patient (endometriosis, adenomyosis), wherein primary infertility 6 example, secondary infertility 7 example; Merge patients with uterine myoma 10 people, wherein 2 examples are from primary dysmenorrhea group, and 8 examples are from secondary dysmenorrhea group.

1.2.2 matched group

84 routine 14 ~ 44 years old matched group women age, average 29.71 ± 6.71 years old; Married 50 people (59.52%), unmarried 34 people (40.48%).Be in December, 2011 to 2012 year March the medical non-dysmenorrhea person of medical pharmaceutical university attached east hospital, the People's Hospital of city Out-patient Clinic of Department of Gynecology, be diagnosed as vaginitis etc., or normal person.

Infertile person 3 people is there is, wherein primary infertility 1 people, secondary infertility 2 people in 84 people; There is patients with uterine myoma 1 people.

1.3 investigation content

The ordinary circumstances such as survey items has age, wedding condition, blood group, height, body weight, occupation, education degree, menstruation, leukorrhagia situation, at ordinary times symptom, motherhood history, contraceptives, history of operation, previously dysmenorrhea history, the content such as family history and living habit, and the subordinate list such as World Health Organization's life quality chart abridged table (WHOQOL.BREF), formulate corresponding application form according to investigation content, to the person of including in, inquired and record by special messenger doctor.

(2) Standards of Chinese Medical Syndrome Differentiation

Premenstrual or cold-type pain in the lower abdomen during menstruation, pain alleviated while getting warmth; Delayed menstrual cycle, amount is few; Menses are dim and have stasis of blood block or as decoction of black soybean sample; Fear of cold, the hands and feet being not warm; Profuse leukorrhea; Tongue fur is white or greasy, stringy pulse or heavy tight.Cold blood stasis causes the situation of dysmenorrhea very general.Women take blood as this, belongs to cloudy; Cold being a kind of YIN pathogen, People of the same tastes and habits like to be together, and women itself easily feels cold-evil and causes gynaecopathia.Primary symptom: premenstrual or menstrual period few abdomen cold type of pain, pain alleviated while getting warmth, simultaneous phenomenon: 1. month through or see and postpone, amount is few, dim and have tired piece or as decoction of black soybean sample through color; 2. complexion is bluish white; 3. cold extremities with aversion to cold; 4. nausea and vomiting, waist bones of the body distending pain or rectal tenesmus; 5. the dim tongue of tongue is white; 6. deep-thready pulse or stringy and tense pulse, wherein cardinal symptom is indispensable, and simultaneous phenomenon possesses 2 and can diagnose.

(3) dysmenorrhea grade scale

Draft with reference to " guideline of clinical investigations of new Chinese medicine treatment dysmenorrhea " (version in 1993):

1. severe: menstrual period or lower abdomen hurt like hell before and after it, feel restless, have a strong impact on work, study and daily life, must lie up, ache with waist, complexion is looked into the distance white, dripping cold sweat, extreme cold of the limbs, vomiting and diarrhoea, or rectal tenesmus, adopt pain relieving measure without obvious alleviation, dysmenorrhea symptom integral is more than 14 points;

2. moderate: menstrual period or lower abdomen hurt like hell before and after it, companion's waist is ached, nausea and vomiting, and extremity are not warm, and postpone separating with pain relieving measure, dysmenorrhea symptom integral is at 8 ~ 13.5 points;

3. slight: menstrual period or before and after it lower abdomen pain obvious, companion's waist is ached, but can adhere to work, and without General Symptoms, sometimes must take analgesic, dysmenorrhea symptom integral is below 8 points.

(4), exclusion standard

(1) the Syndrome Differentiation of Traditional Chinese Medicine person that do not belong to cold blood stasis; (2) dysmenorrhea caused by pelvic inflammatory disease, endometriosis, uterus tumor is confirmed on inspection; (3) to known applications drug allergy person; (4) the severe primary diseases such as cardiovascular and cerebrovascular vessel, liver, kidney and hemopoietic system are associated with, psychotic; (5) do not meet inclusive criteria, not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person; (6) do not agree to reception test group or treatment of control group, do not sign the patient of Informed Consent Form.

Concrete condition illustrates: 1. medication is more than 1 menstrual cycle person, should enter curative effect statistics; More than medication 1 cycle (comprising 1 cycle) invalid stop using or use other similar therapeutic medicines instead, should by invalidation, not in the scope of coming off, the present invention treats in the observation of curative effect of qi depression to blood stasis dysmenorrhea; 2. medication does not reach the experimenter of 9 days, can be considered the case that comes off; 3. the patient that pair midway proposes to exit test by patient clearly will record reason; Medication is passed through and last administration time; 4. the patient of pair lost to follow-up or institute's further consultation that do not come in time, should make great efforts by telephone questionnaire reason, investigate its medication process, last administration time, and keep a record; 5. evaluation index when itemized record stop, stopping test or come off will conscientious record with the relation of test, analyzes and stops case may affect research conclusion; 6. keep the raw data of all rejectings and the case that comes off.

Five, grouping and test method

(1) EXPERIMENTAL DESIGN

This research adopts clinical experimental study method, selects ibuprofen modified release capsule as standard control medicine, using the present invention as test group, Chinese medicine pharmacy of institute decocts to 200ml by prescription unification by me, sealing, and menstruation first day starts oral, day 1 dose, and sub-service sooner or later, serve on 3 days; With ibuprofen modified release capsule group for matched group, the same day in menstrual period oral ibuprofen slow releasing capsule 30mg, 1 time/d, namely pain only stops using, being used in conjunction 3 menstrual cycle was 1 course for the treatment of, and observing time is 3 months, by comprehensive therapeutic effect, disease curative effect, the change of primary symptom and simultaneous phenomenon, and the change etc. of check result as erythrocyte sedimentation rate value of Binding experiment room carries out clinical observation to two kinds of these diseases of Drug therapy.

Whole process of the test arrangement is made a house call for 6 times, make a house call for 1st time and be arranged in case screening, informed consent postscript is signed patient, carry out corresponding inquiring, health check-up and lab testing, if patient meets inclusion criteria, a medicine numbering will be distributed in order, i.e. random number, and arrange to enter first month through cycle therapy; Make a house call for 2nd time after being arranged in treatment menstrual cycle, further consultation before menstrual cycle next time; Make a house call for 3rd time after being arranged in treatment two menstrual cycle, under further consultation before menstrual cycle successively, treatment 3 menstrual cycle are 1 course for the treatment of continuously; After drug withdrawal, follow up a case by regular visits to 3 months continuously, monthly to patient's telephone questionnaire once, the improvement of clinical symptoms and sign are detected, evaluate Drug safety and effectiveness.

(2) sample size

Selector closes and states the 80 cases of test case standard, often organizes each 40 examples.

(3) medicine and usage

1. medicine name

Trial drug: the present invention, by Shandong, Chinese medicine pharmacy of institute of traditional Chinese medicine provides, prescription: Radix Rehmanniae Preparata 12g, Herba Epimedii 13g, Fructus Foeniculi 12g, Radix Angelicae Sinensis 13g, Herba Leonuri 13g, Oletum Trogopterori 12g, Radix Astragali 13g, Herba Taxilli 13g, Cortex Moutan 13g, Cortex Cinnamomi 12g, Fructus Rubi 13g, Myrrha 12g, Sanguis Draxonis 13g, Radix Curcumae 13g, Radix Paeoniae Rubra 13g, Flos Campsis 12g, Rhizoma Cyperi 12g, Rhizoma Corydalis 12g, Radix Salviae Miltiorrhizae 13g, Rhizoma Chuanxiong 12g, Caulis Spatholobi 12g, Rhizoma Sparganii 12g; External: Fructus Foeniculi 15g, Fructus Cnidii 15g, Eupolyphaga Seu Steleophaga 15g, Radix Dipsaci 14g, Herba Asari 13g, Radix Salviae Miltiorrhizae 13g, Radix Linderae 12g, Herba Patriniae 12g, Ramulus Cinnamomi 13g, Folium Artemisiae Argyi 12g, Fructus Toosendan 12g, Flos Carthami 13g;

Use in menstruation complete 2nd day coloclysis or make suppository and put into intravaginal, be used in conjunction 15 days once a day.

Control drug: ibuprofen modified release capsule, is produced by Sino-America Tianjin Shike Pharmaceutical Co., Ltd., authentication code: the accurate word H 1,090 0089 of traditional Chinese medicines, batch number: 08110660, every 0.39g, specification: 20/box.

2. test the course for the treatment of: being used in conjunction 3 menstrual cycle was 1 course for the treatment of, judged curative effect after observing 3 menstrual cycle.

3. drug combination: duration of test must not add with in relevant with treatment primary disease, Western medicine product and other means.

(2) tcm syndrome efficacy assessment standard (with reference to nimodipine method)

Statistical analysis plan: application SPSS13.0 statistical package, after homogeneity of variance is analyzed, measurement data compares employing t inspection, and enumeration data adopts x ²inspection, ranked data adopt rank test, compare and adopt paired t-test " (note: all represent mean with-x below) in group

Experiment: patient 80 example meeting inclusive criteria is collected in this clinical trial altogether, and patient dependence is good, and no one is lost to follow-up.

The present invention treats the observation of curative effect of qi depression to blood stasis dysmenorrhea

The comparison (n, %) of table 1 liang group patient therapeutic effect of syndrome

The comparison of two groups of patient's disease curative effects is used and is expanded inspection calculating, x ²=12.831, P=0.010, two groups of cure rates, obvious effective rate, the group difference of effective percentage, inefficiency, total effective rate all has statistical significance.

After table 2 liang group patient treatment, dysmenorrhea integral difference compares (-x ± s)

The difference of the comprehensive therapeutic effect between two groups before and after patient treatment calculates through the t inspection of two independent samples, and P<0.05, the two curative effect has statistical significance.

Compare in the group of table 3 liang group Patient Global curative effect

The comparison (-x ± s) of pain degree integration before and after table 3 liang group patient treatment

Group	n	(divide) before treatment	After treatment (dividing)	t	P
						Test group	40	9.28±2.693	5.45±2.834	11.34	0.000
Matched group	40	9.88±2.791	6.52±2.125	10.12	0.000

Calculate through paired t-test, P<0.001, before and after two groups of patient treatments, therapeutic effect of syndrome integral contrast has significant difference.

Table 4, two groups of pain relieving onset times compare (n/%)

Group	n	Invalid	30min	1h	1.5h	2
							Test group	40	2(5)	17(42.5)	9(22.5)	8(20)	4(10)
Matched group	40	3(7.5)	26(65)	10(25)	1(2.5)	0

Before and after table 5 liang group treatment, the hypogastralgia time compares (n)

L () calculates through the rank test of matched-pair design data, before and after test group treatment, the hypogastralgia time compares, Z=2.611, P=0.009; Before and after treatment of control group, the hypogastralgia time compares; Z=2.426, P=0.00, before and after two groups of treatments, the difference of hypogastralgia time all has statistical significance.

(2) under completely randomized design, the rank test of two groups of ordered set data calculates, Z=2.426, P=0.015, two groups of treatments

The rear hypogastralgia time compares, and group difference has statistical significance, and the average sum of ranks of test group and matched group is 35.30,45.70.

The comparison of table 6. liang group patient simultaneous phenomenon curative effect

After table 6 liang group treatment, simultaneous phenomenon improvement situation compares (n)

Calculating through separating inspection, comparing before and after test group treatment, x ²=12.614, P=0.047, difference has statistical significance: compare before and after treatment of control group, x ²=7.030, P=0.436, no significant difference.

The comparison of table 7 liang group patient secondary efficacy index

The comparison (-x ± s) of erythrocyte sedimentation rate value before and after table 7 liang group patient treatment

Before and after two groups of patient treatments, erythrocyte sedimentation rate value calculates through paired t-test, P<0.05, and the difference before and after treatment has statistical significance

1. safety detects: in treatment and observation process thereof, routine blood test, the two just routine examination before and after of the present invention group of patient treatment, electrocardiogram, hepatic and renal function all do not find obvious exception.

2. untoward reaction: in treatment and observation process thereof, do not have patient to tell any discomfort and allergic phenomena.

Discuss

Dysmenorrhea is one of modal disease of gynecological, and its incidence rate report differs, and account for 42% ~ 90%, wherein severe pain is through accounting for 18%.Dysmenorrhea is a disease that is long-term, easily recurrent exerbation, can accompany nausea and vomiting, dripping cold sweat, deadly cold hand and foot, very then faint, affect life and work more time serious, totally unfavorable to the physical and mental health of women.In treatment, the appearance of PGSI, the sickness rate of this disease is greatly reduced, ibuprofen modified release capsule has stronger antiinflammatory, pain relieving, refrigeration function, by suppressing prostaglandin synthetase, thus suppresses the synthesis of prostaglandin, produce anti-inflammatory analgesic effect, therefore ibuprofen modified release capsule is premenstruum, and use has the effect prevented irritation, using menstrual period has spasmolytic, analgesic activity, is characterized in that administration is easy, instant effect.But because its symptom mainly for its pain is eased pain, improve not good to simultaneous phenomenon, thoroughly can not cure dysmenorrhea, and because of side effect larger, can cause nausea, vomit, the gastrointestinal upset such as diarrhoea, also can cause stomatitis, dizziness, tinnitus, blurred vision, the untoward reaction such as erythra, therefore still can not think that oral ibuprofen slow releasing capsule is the Perfected process for the treatment of dysmenorrhea.Chinese medicine is started with by entirety, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs demonstrates obvious advantage.For " addiction blood " pathogenesis of dysmenorrhea, endocrine disturbance is main pathogeny, in conjunction with the modern pharmacological research achievement of Chinese medicine, explores traditional Chinese medical herbal treatment dysmenorrhea and has vast potential for future development.

Claims

1. treat the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type for one kind, it is characterized in that, in described Chinese medicine composition, oral preparations comprises the crude drug of following weight portion: 10 ~ 20 parts, Radix Rehmanniae Preparata, Herba Epimedii 10 ~ 20 parts, Fructus Foeniculi 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, in described Chinese medicine composition, external preparation comprises the crude drug of following weight portion: Fructus Foeniculi 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, the Radix Linderae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Fructus Toosendan 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami.

2. treat the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type according to claim 1, it is characterized in that, in described Chinese medicine composition, oral preparations comprises the crude drug of following weight portion: 10 ~ 15 parts, Radix Rehmanniae Preparata, Herba Epimedii 10 ~ 15 parts, Fructus Foeniculi 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Oletum Trogopterori 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Herba Taxilli 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Myrrha 10 ~ 20 parts, Sanguis Draxonis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, in described Chinese medicine composition, external preparation comprises the crude drug of following weight portion: Fructus Foeniculi 10 ~ 15 parts, Fructus Cnidii 10 ~ 15 parts, Eupolyphaga Seu Steleophaga 10 ~ 15 parts, Radix Dipsaci 10 ~ 15 parts, Herba Asari 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, the Radix Linderae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Fructus Toosendan 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami.

3. treat the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type according to claim 1, it is characterized in that, in described Chinese medicine composition, oral preparations comprises the crude drug of following weight portion: 10 ~ 20 parts, Radix Rehmanniae Preparata, Herba Epimedii 10 ~ 20 parts, Fructus Foeniculi 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Herba Taxilli 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Myrrha 10 ~ 15 parts, Sanguis Draxonis 10 ~ 15 parts, Radix Curcumae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Flos Campsis 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Rhizoma Sparganii 10 ~ 15 parts, in described Chinese medicine composition, external preparation comprises the crude drug of following weight portion: Fructus Foeniculi 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Radix Dipsaci 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, the Radix Linderae 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Ramulus Cinnamomi 10 ~ 15 parts, Folium Artemisiae Argyi 10 ~ 15 parts, Fructus Toosendan 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami.

4. as described in any one of Claims 1 to 4 item, treat a preparation method for the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type, it is characterized in that, when the oral preparations of described Chinese medicine composition is capsule, its preparation process is:

5. treat the preparation method of the oral capsule of the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type according to claim 4, it is characterized in that, in described step a, getting all crude drug steeps in water, add in the water accounting for its quality 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, obtains component 1.

6. treat the preparation method of the oral capsule of the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type according to claim 4, it is characterized in that, in described step b, the medicinal residues of crude drug said extracted crossed add ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, extractum is added the extraction into ethyl acetate secondary accounting for its 4 times amount, extract has reclaimed ethyl acetate, become extractum, obtain component 2.

7. treat the preparation method of the oral capsule of the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type according to claim 4, it is characterized in that, in described step c, extract extractum by above-mentioned two kinds to merge, when concentrating under reduced pressure relative density is 80 DEG C 1.35 extractum, reclaim ethanol, above-mentioned two kinds of extracting solution are inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the extractum of 1.60, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again and is condensed into extractum, is dried to powder tank encapsulated.

8. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type, it is characterized in that, when the external preparation of described Chinese medicine composition is suppository, its preparation process is:

9. treat the preparation method of menorrhalgia of cold-stagnation and blood-stasis type suppository according to claim 8, it is characterized in that, described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, and add the fine drug powder that preparation method described in claim 8 is obtained, stirring in water bath is even, be mixed into the liquid of thickness, be poured in plastic shape-forming pipe, insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described powder Chinese patent medicine and substrate is 1: 2 ~ 1: 4; Described tampon is the tampon of afterbody with cotton thread.

10. as described in any one of claims 1 to 3 item, treat the preparation method of the Chinese medicine composition of menorrhalgia of cold-stagnation and blood-stasis type for one kind, it is characterized in that, the preparation process when external preparation of described Chinese medicine composition is enema is: put into except Folium Artemisiae Argyi, the Radix Linderae, Herba Asari and Fructus Foeniculi by described crude drug after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 30%, collects by the crude drug fine powder of 100 mesh sieves for subsequent use; Again the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; In described steps d, crystallization of Folium Artemisiae Argyi, the Radix Linderae, Herba Asari and Fructus Foeniculi distillation being vaporized to obtain, is dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.46, stir evenly after adding the crystalline powder of fine powder and the distillation of sieving, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.50 extractum, heating be condensed into pasty state, ultraviolet virus killing after use.