CN105168271A - Preparation method and application of non-decocting preparation of fresh flower crude medicine - Google Patents
Preparation method and application of non-decocting preparation of fresh flower crude medicine Download PDFInfo
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Abstract
The invention provides a preparation method and an application of a non-decocting preparation of a fresh flower crude medicine and belongs to the technical field of traditional Chinese medicine preparation. According to the preparation method of the non-decocting preparation of the fresh flower crude medicine, firstly, a special high-speed breaking and centrifuging device is adopted to break the fresh flower crude medicine at a high speed, a flow-state crude medicine is obtained and subjected to ultrasonic wave and microwave coprocessing and filtering, a filtrate is subjected to ethanol precipitation and impurity removal, then a supernatant liquid is concentrated, dried, superfinely ground and sterilized, and a finished product is obtained. The preparation method is simple to control, green and environment-friendly, the processing steps have synergistic interaction, so that the preparation method has higher universality, the extraction efficiency is high, active ingredients are protected effectively, and the availability of the finished product of the fresh flower crude medicine is improved better.
Description
Technical field
The invention belongs to Chinese drug preparation technique field, be specifically related to preparation method and application thereof that fresh flos materia medica exempts from fried dose.
Background technology
Chinese medicine is Chinese nation's crystallization of wisdom, for ensureing that people ' s health has made tremendous contribution.The traditional dosage form of Chinese medicine has pill, powder, unguentum, medicated wine etc., but the deficiencies such as conventional dosage forms majority exists, and taking dose is large, dosage form thick, appearance poor, along with the raising of social development and people's economic level, these deficiencies have seriously constrained the paces of Chinese medicine development, introduce high-tech, utilizing new technique to improve the quality of Chinese medicine, is one of important channel of innovation of Chinese medicinal dosage form.
Flos materia medica refers to that medicinal part is a class medical material of plant flowers, because of its be subject to many factors cause rotten, go mouldy, loose gas etc., storage, keeping are preserved than general medical material difficulty.Sporadicly gather because Chinese crude drug mostly is, purchase successively, dry the wetting of medical material itself is differed, and packaging material are very simple again, very easily make moist by ectocine.The often member packing of some medical materials, if medical material itself is not done, inner heat, heat can not outwards distribute, and under suitable temperature and humidity environment, very easily goes mouldy.This type of medicine moisture-sensitive, causes the absorbed air water yield, easily generates heat, and can cause going mouldy, to consume nutrient too much etc., the directly property of medicine of impact flower.Many flowers are as Flos Caryophylli, Flos Rosae Rugosae, Flos Rosae Chinensis, Stigma Croci, Flos Lonicerae etc., this type of medical material is often containing volatile ingredient, and these compositions mostly have been the important substance of therapeutical effect, if be heated in medical material storage, medical material own temperature raises, and the volatile ingredient making it contain scatters and disappears; Or tight because packing, medical material exposes and causes volatile ingredient nature volatilization loss, and medical material abnormal smells from the patient is changed, and effective ingredient reduces and reduces or lose curative effect.Most flower class Chinese medicine contains different pigments because of it, if medicinal material drying temperature is too high, resting period is long, sunlight is too much, the oxygen in air, high temperature, generates heat, makes moist, the effect of enzyme, fumigating of sulfur, all can cause the change of medical material color and luster, cause the change of medical material inherent quality and affect its effect.
For the variety of problems existed in above-mentioned flos materia medica Preparation process, if inventor proposes not carry out concocting directly entering the processed stage after flos materia medica is gathered, both the cost of the process of preparing Chinese medicine, transport, preservation can have been reduced, the loss of active substance can be reduced again, certain market prospect certainly will be had.
At present, the Land use systems of flos materia medica is generally comprised to the preparation of single extract, as extracted polysaccharose substance, polyphenols, Flavonoid substances, triterpene substance etc.; Also comprise as compatibility medical material use etc.And the preparation of single extract can cause Chinese medicine to lose original compound recipe characteristic, limit its application in prescription drug.Secondly, taking still based on decoction of formula Chinese medicine.Although in the place of conditions permit, the deposit such as Partial Hospitals, outpatient service has compound decoction finished product, only need heat namely drinkable, but the curative effect of each secondary compound decoction finished product is fixed, can not dissolve as required, motility is poor, stores compound decoction finished product simultaneously, there is problems such as taking up room, waste energy, and compound decoction finished product is in deposit process, drug effect also can be faded.Even extract and other Chinese crude drug are prepared into compound preparation, because formula is fixed, curative effect is determined, its range of application also can be subject to certain restrictions.
Therefore, finding efficacy stability, storing the preparation method of simple, that motility is strong flos materia medica is the task of top priority.
Summary of the invention
Technical problem to be solved by this invention is, for the deficiencies in the prior art, provides a kind of efficacy stability, effectively extracts and protects the fresh flos materia medica of effective ingredient to exempt from the preparation method of fried dose.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: fresh flos materia medica exempts from the preparation method of fried dose, comprises the following steps:
1) by fresh flos materia medica trickle cleaning surface impurity, slight oscillatory removes surface moisture, then drops in the broken centrifugal device of specialized high-speed and processes, obtain fluidised form medical material;
2) the fluidised form medical material that taking-up step 1) obtains is placed in reactor, add the water of its volume 3 ~ 8 times, reactor is airtight, adopt ultrasonic-microwave associated treatment, holding temperature is 12 ~ 15 DEG C, is filtered by the fluidised form medical material after process, obtains filtrate and filtering residue, filtering residue is proceeded to step 1) reprocessing, filtrate then proceeds to step 3);
3) in step 2) add ethanol in gained filtrate, make the volume fraction of ethanol reach 70 ~ 75%, 2 ~ 8 DEG C leave standstill 8 ~ 10h, get supernatant liquid, reclaim ethanol, being concentrated into relative density is 1.08 ~ 1.13(75 ~ 80 DEG C) mastic, dry, micronizing, sterilizing, obtains fresh flos materia medica and exempts from fried dose.
Preferably, described fresh flos materia medica is that this area can the flos materia medica that is used as medicine of fresh goods.
Preferably, the broken centrifugal device of described specialized high-speed, comprise container containing, centrifuge container, broken cutting mechanism, controlling organization, motor, scraping mechanism, described motor is connected with controlling organization, described container containing is arranged on the outside of centrifuge container, described broken cutting mechanism is arranged in centrifuge container, and drive with motor and be connected, the blade that described broken cutting mechanism comprises rotating shaft and is connected with described rotating shaft, described blade is around described shaft circumference Heterogeneous Permutation, the inwall of described centrifuge container arranges the catch to described centrifuge container bottom angled, the wall of described centrifuge container arranges the filter opening communicated with described container containing, described filter opening flare structure, large mouth is towards the inside of described centrifuge container, the top of described centrifuge container arranges charging aperture, the bottom of described container containing arranges discharging opening, between described container containing and centrifuge container, scraping mechanism is set.
Preferably, step 2) described in the process conditions of ultrasonic-microwave associated treatment be: ultrasonic power 150 ~ 300W, microwave power 230 ~ 380W, extraction time 5 ~ 10min, number of repetition 2 ~ 5 times, each interval is no less than 5 minutes.
Preferably, dry for described mastic is carried out lyophilization described in step 3).
Preferably, micronizing described in step 3) is, through super micron mill, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75Mm.
Present invention also offers the fresh flos materia medica of above-mentioned preparation method gained and exempt from the fried dose of application in compound preparation, fresh flos materia medica being exempted from fried dose directly adds in described compound preparation, make pharmaceutically acceptable dosage form, comprise liquid preparation, granule, tablet, capsule, injection, powder, unguentum, pill.
Preferably, present invention also offers the fresh flos materia medica of above-mentioned preparation method gained and exempt from the fried dose of application in compound preparation, fresh flos materia medica is exempted from fried dose and directly adds in described compound preparation, make Chinese medicine compound liquid preparation.
Compared with prior art, its beneficial effect is in the present invention:
First the present invention adopts the broken centrifugal device of specialized high-speed to carry out high-speed breakage to fresh flos materia medica material, by the cutting of broken cutting mechanism, effect of impact between material, between material and chamber wall, make the cell wall rupture of Chinese crude drug cell, intracellular effective ingredient flows out, and is then thrown away by fluidised form medical material by centrifugal, collides again with container containing, then converge, discharging; Then ultrasonic-microwave associated treatment is carried out to the fluidised form medical material of discharging, strengthens further the stripping of effective ingredient, then precipitate with ethanol, filtration, filtrate is concentrated, dry, then pulverize, sterilizing, get product.Whole process control of the present invention is simple, environmental protection, each processing step Synergistic; make preparation method universality of the present invention stronger; extraction efficiency is higher, and active component obtains available protecting, improves the availability of fresh flos materia medica material finished product preferably.
Figure of description
Fig. 1: the structural representation of the broken centrifugal device of a kind of specialized high-speed of the present invention;
Fig. 2: the structural representation of blade in Fig. 1 of the present invention.
Detailed description of the invention
In order to understand the present invention better, set forth content of the present invention below in conjunction with embodiment is clear further, but protection content of the present invention is not only confined to the following examples.In the following description, a large amount of concrete details is given to provide more thorough understanding of the invention.But, it will be apparent to one skilled in the art that the present invention can be implemented without the need to these details one or more.In other example, in order to avoid obscuring with the present invention, technical characteristics more well known in the art are not described.
The invention provides the preparation method that fresh flos materia medica exempts from fried dose, can according to the following steps:
1) by fresh flos materia medica trickle cleaning surface impurity, slight oscillatory removes surface moisture, then drops in the broken centrifugal device of specialized high-speed and processes, obtain fluidised form medical material; In this step, when the water content of fresh flos materia medica be low to moderate be not enough to after treatment form fluidised form time, need before this Chinese medicine adds the broken centrifugal device of specialized high-speed, add a certain amount of moisture wherein, ensure that it after treatment, can become flow-like medical material to flow out, amount of water is 0 ~ 3 times of Chinese crude drug weight;
2) the fluidised form medical material that taking-up step 1) obtains is placed in reactor, add the water of its volume 3 ~ 8 times, reactor is airtight, adopt ultrasonic-microwave associated treatment, holding temperature is 12 ~ 15 DEG C, is filtered by the fluidised form medical material after process, obtains filtrate and filtering residue, filtering residue is proceeded to step 1) reprocessing, filtrate then proceeds to step 3); In this step, the process conditions of described ultrasonic-microwave associated treatment are: ultrasonic power 150 ~ 300W, microwave power 230 ~ 380W, extraction time 5 ~ 10min, number of repetition 2 ~ 5 times, and each interval is no less than 5 minutes; Accelerate breaking of cell wall further by ultrasonic-microwave process, strengthen the release of intracellular organic matter, diffusion and dissolving.
3) in step 2) add ethanol in gained filtrate, make the volume fraction of ethanol reach 70 ~ 75%, 2 ~ 8 DEG C leave standstill 8 ~ 10h, get supernatant liquid, reclaim ethanol, being concentrated into relative density is 1.08 ~ 1.13(75 ~ 80 DEG C) mastic, dry, micronizing, sterilizing, obtains fresh flos materia medica and exempts from fried dose.
In this step, described concentrating can be carried out in vacuum-concentrcted equipment, and vacuum-concentrcted can reduce the boiling point of material, increases the temperature difference of steam and storeroom, and improve concentrated speed, thermal loss is few, concentrates at low ambient temperatures, can prevent the loss of heat-sensitive materials.Described mastic is preferably carried out lyophilization by described drying, concrete, mastic is put into vacuum freeze drier, closes hermatic door, open vacuum pump switch and freeze dryer switch, be evacuated to 5kPa ~ 12kPa, start refrigeration simultaneously, in 4 hours, the condenser temperature of vacuum freeze drier is down to-20 DEG C ~-40 DEG C, 1 ~ 3 hour retention time, by heating system, mastic is slowly heated, in 8 ~ 20 hours, mastic is warming up to 0 ~ 12 DEG C, make mastic dry.Described micronizing is, through super micron mill, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75Mm.Preferred pulverization conditions is: temperature-30 ~-10 DEG C, time 5 ~ 30min, through micronizing, material is under the effects such as impact, collision, shearing, grinding, dispersion, overcome solid interior cohesiveness and make material broken, the dissolution of effective ingredient increases further, and take assimilation effect better, availability is higher.The present invention also comprises and exempts from fried dose to the fresh flos materia medica of gained and carry out sterilizing.The present invention there is no particular determination to sterilizing, and can be sterilizing methods well known to those skilled in the art, the present invention preferably adopts low temperature sterilization.
In the present invention, the broken centrifugal device of described specialized high-speed, consult Fig. 1, it comprises container containing 1, centrifuge container 2, broken cutting mechanism, controlling organization, motor 3 and scraping mechanism, motor 3 is connected with controlling organization, container containing 1 is arranged on the outside of centrifuge container 2, broken cutting mechanism is arranged in centrifuge container 2, and drive with motor 3 and be connected, the blade 5 that broken cutting mechanism comprises rotating shaft 4 and is connected with rotating shaft 4, described blade 5 is 4 circumference Heterogeneous Permutations around the shaft, the inwall of centrifuge container 2 arranges the catch 6 to centrifuge container 2 bottom angled, the wall of centrifuge container 2 arranges the filter opening 7 communicated with container containing 1, filter opening 7 flare structure, large mouth is towards the inside of centrifuge container 2, the top of centrifuge container 2 arranges charging aperture 8, the bottom of container containing 1 arranges discharging opening 9, between container containing 1 and centrifuge container 2, scraping mechanism is set.
In the broken centrifugal device of above-mentioned specialized high-speed, motor 3 adopts high-speed electric expreess locomotive.Filter opening 7 is tubaeform, and large mouth (one end that namely diameter is large) is towards the inside of centrifuge container 2, and osculum (one end that namely diameter is little) is towards container containing 1, and the diameter of osculum is 0.1 ~ 1 millimeter.Wherein, the blade 5 that broken cutting mechanism comprises rotating shaft 4 and is connected with rotating shaft 4, blade 5 is around described rotating shaft 4 circumference Heterogeneous Permutation.Wherein, rotating shaft 4 exceeds the bottom of centrifuge container, and one end of blade 5 is located in rotating shaft 4, and blade 5 is around rotating shaft Heterogeneous Permutation between two.As shown in Figure 2, blade 5 is flat, and symmetrical, both sides are arc, and with sharp-pointed sawtooth 11 on arcuate structure.As shown in Figure 1, scraping mechanism comprises scraper plate 10-1,10-2, horizontal plate 10-3, telescopic scraping arm 10-4, bracing frame 10-5, motor 10-6 and switch, scraper plate comprises scraper plate I 10-1 coincide with the inwall of container containing 1 and scraper plate II 10-2 coincide with the outer wall of centrifuge container 2, scraper plate I is connected by horizontal plate 10-3 with the upper end of scraper plate II, horizontal plate is connected with telescopic scraping arm 10-4, telescopic scraping arm is multiple, is all electrically connected successively with motor 10-6, switch by bracing frame 10-5.
During use, fresh Herba Dendrobii after draining is dropped in centrifuge container by the charging aperture 8 at centrifuge container 2 top, close charging aperture 8, open motor 3, rotating shaft high-speed rotation, blade cuts Herba Dendrobii repeatedly, broken cut after Herba Dendrobii particle diameter be centrifuged power when being less than or equal to the filter footpath of filter opening and throw away, enter in container containing, converge a certain amount of after, by discharging opening 9 flow out enter in collecting mechanism.Treat that Herba Dendrobii in centrifuge container 2 is broken and cut end, disable motor 3.Open motor 10-6, scraping plate mechanism is started working, the outer wall of inwall and centrifuge container 2 that scraper plate 10-1,10-2 against container containing 1 moves up and down, and is scraped by the fluidised form Herba Dendrobii on the outer wall of the inwall of container containing 1 and centrifuge container 2, is flowed out by discharging opening 9.
The broken centrifugal device of specialized high-speed in the present invention involved by following embodiment is all expressed as standard by with above-mentioned, repeats no more.
Present invention also offers the fresh flos materia medica of above-mentioned preparation method gained and exempt from the fried dose of application in compound preparation, fresh flos materia medica being exempted from fried dose directly adds in described compound preparation, make pharmaceutically acceptable dosage form, comprise liquid preparation, granule, tablet, capsule, injection, powder, unguentum, pill.
In the present invention, described fresh flos materia medica is that this area can the flos materia medica that is used as medicine of fresh goods, as Flos Granati, Herba Saussureae Involueratae, Folium Rhododendri Simsii, Flos lilli concoloris Salisb..
Below by specific embodiment, those skilled in the art can be implemented.
Embodiment 1
For Flos Granati, the preparation method of fried dose exempted from by its Chinese medicine, carries out in the steps below:
1) by fresh Flos Granati trickle cleaning surface impurity of gathering, slight oscillatory removes surface moisture, then drops in the broken centrifugal device of specialized high-speed and processes, obtain fluidised form medical material;
2) the fluidised form medical material that taking-up step 1) obtains is placed in reactor, adds the water of its volume 5 times, and reactor is airtight, adopt ultrasonic-microwave associated treatment, adopt ultrasonic power 200W, microwave power 300W, extraction time 6min, number of repetition 3 times, each interval is no less than 5 minutes, and during process, holding temperature is 12 DEG C, fluidised form medical material after process is filtered, obtain filtrate and filtering residue, filtering residue is proceeded to step 1) reprocessing, filtrate then proceeds to step 3);
3) in step 2) add ethanol in gained filtrate, the volume fraction of ethanol is made to reach 75%, 2 DEG C of standing 8h, get supernatant liquid, reclaim ethanol, being evaporated to relative density is 1.10(75 DEG C) mastic, vacuum lyophilization, at temperature is for-15 DEG C, carry out micronizing, grinding time is 18min, sterilizing, must exempt to decoct finished dosage form.
Embodiment 2
For Flos Granati, the preparation method of fried dose exempted from by its Chinese medicine, carries out in the steps below:
1) by fresh Flos Granati trickle cleaning surface impurity of gathering, slight oscillatory removes surface moisture, then drops in the broken centrifugal device of specialized high-speed and processes, obtain fluidised form medical material;
2) the fluidised form medical material that taking-up step 1) obtains is placed in reactor, adds the water of its volume 3 times, and reactor is airtight, adopt ultrasonic-microwave associated treatment, adopt ultrasonic power 150W, microwave power 250W, extraction time 5min, number of repetition 4 times, each interval is no less than 5 minutes, and during process, holding temperature is 12 DEG C, fluidised form medical material after process is filtered, obtain filtrate and filtering residue, filtering residue is proceeded to step 1) reprocessing, filtrate then proceeds to step 3);
3) in step 2) add ethanol in gained filtrate, the volume fraction of ethanol is made to reach 75%, 4 DEG C of standing 8.5h, get supernatant liquid, reclaim ethanol, being evaporated to relative density is 1.10(75 DEG C) mastic, vacuum lyophilization, at temperature is for-15 DEG C, carry out micronizing, grinding time is 20min, sterilizing, must exempt to decoct finished dosage form.
Embodiment 3
For Flos Granati, the preparation method of fried dose exempted from by its Chinese medicine, carries out in the steps below:
1) by fresh Flos Granati trickle cleaning surface impurity of gathering, slight oscillatory removes surface moisture, then drops in the broken centrifugal device of specialized high-speed and processes, obtain fluidised form medical material;
2) the fluidised form medical material that taking-up step 1) obtains is placed in reactor, adds the water of its volume 8 times, and reactor is airtight, adopt ultrasonic-microwave associated treatment, adopt ultrasonic power 300W, microwave power 350W, extraction time 8min, number of repetition 3 times, each interval is no less than 5 minutes, and during process, holding temperature is 12 DEG C, fluidised form medical material after process is filtered, obtain filtrate and filtering residue, filtering residue is proceeded to step 1) reprocessing, filtrate then proceeds to step 3);
3) in step 2) add ethanol in gained filtrate, the volume fraction of ethanol is made to reach 70%, 8 DEG C of standing 10h, get supernatant liquid, reclaim ethanol, being evaporated to relative density is 1.10(75 DEG C) mastic, vacuum lyophilization, at temperature is for-15 DEG C, carry out micronizing, grinding time is 20min, sterilizing, must exempt to decoct finished dosage form.
Embodiment 4
For Folium Rhododendri Simsii, the preparation method of fried dose exempted from by its Chinese medicine, carries out in the steps below:
1) by fresh Folium Rhododendri Simsii trickle cleaning surface impurity of gathering, slight oscillatory removes surface moisture, then drops in the broken centrifugal device of specialized high-speed and processes, obtain fluidised form medical material;
2) the fluidised form medical material that taking-up step 1) obtains is placed in reactor, adds the water of its volume 4 times, and reactor is airtight, adopt ultrasonic-microwave associated treatment, adopt ultrasonic power 150W, microwave power 380W, extraction time 10min, number of repetition 2 times, each interval is no less than 5 minutes, and during process, holding temperature is 15 DEG C, fluidised form medical material after process is filtered, obtain filtrate and filtering residue, filtering residue is proceeded to step 1) reprocessing, filtrate then proceeds to step 3);
3) in step 2) add ethanol in gained filtrate, the volume fraction of ethanol is made to reach 75%, 2 DEG C of standing 8h, get supernatant liquid, reclaim ethanol, being evaporated to relative density is 1.08(80 DEG C) mastic, vacuum lyophilization, at temperature is for-10 DEG C, carry out micronizing, grinding time is 15min, sterilizing, must exempt to decoct finished dosage form.
Embodiment 5
For Flos lilli concoloris Salisb., the preparation method of fried dose exempted from by its Chinese medicine, carries out in the steps below:
1) the Flos lilli concoloris Salisb. trickle cleaning surface impurity of gathering fresh, slight oscillatory removes surface moisture, in the broken centrifugal device of specialized high-speed, then add the water of Flos lilli concoloris Salisb. weight 2 times, then drops into Flos lilli concoloris Salisb. and process, and obtains fluidised form medical material;
2) the fluidised form medical material that taking-up step 1) obtains is placed in reactor, adds the water of its volume 4 times, and reactor is airtight, adopt ultrasonic-microwave associated treatment, adopt ultrasonic power 280W, microwave power 230W, extraction time 5min, number of repetition 5 times, each interval is no less than 5 minutes, and during process, holding temperature is 12 DEG C, fluidised form medical material after process is filtered, obtain filtrate and filtering residue, filtering residue is proceeded to step 1) reprocessing, filtrate then proceeds to step 3);
3) in step 2) add ethanol in gained filtrate, the volume fraction of ethanol is made to reach 75%, 6 DEG C of standing 9h, get supernatant liquid, reclaim ethanol, being evaporated to relative density is 1.13(80 DEG C) mastic, vacuum lyophilization, at temperature is for-30 DEG C, carry out micronizing, grinding time is 5min, sterilizing, must exempt to decoct finished dosage form.
Below by experiment embodiment, beneficial effect of the present invention is described.
Drug efficacy study
For a kind of Chinese medicine decoction for the treatment of bronchial asthma
Chinese medicine formula: Folium sophorae 10g, Cortex Lycii 8g, Fluoritum 4g, Cortex Albiziae 2g, Cordyceps 11g, leaf of Caulis Sacchari sinensis 15g, Placenta Hominis 7g, Radix Stemonae 9g, Radix Ginseng 6g, Fructus Arctii 3g, Flos Granati 10g, Cera Flava 11g, Bombyx Batryticatus 5g, Cacumen Platycladi 9g, Fructus Psoraleae 5g, Ramulus Luffae 12g, Radix Ilicis Asprellae 4g, pomelo peel 10g, Rhizoma Fagopyri Dibotryis 11g.
Existing method: each medical material getting above-mentioned weight portion, decocts with water after mixing, makes decoction I.
The inventive method: get fresh Flos Granati (the 10g Flos Granati in said ratio being converted into the weight of fresh Flos Granati), be prepared into Flos Granati by the method for the embodiment of the present invention 1 and exempt to decoct powder; All the other each medical materials are by said ratio, and mixing and water adding decocts, and obtains decoction liquor, then exempt from Flos Granati to decoct powder while hot and add in decoction liquor and fully dissolve, obtain decoction II.
Lanqin oral solutions: tracing observation case is totally 80 examples, is divided into experimental group and matched group at random, often group is respectively 40 examples; Two groups of there was no significant differences in sex, age, the course of disease and the state of an illness etc., have comparability." prevention and control of bronchial asthma guide " mesobronchus Asthma in Remission Stage diagnostic criteria of specifying with reference to respiratory disease association of Chinese Medical Association in 1997 is drafted, all through treatment or untreated symptom, sign disappear, pulmonary function returns to level before acute attack, and the Bronchial Asthmas maintaining more than 4 weeks includes this observation in.Get rid of asthma and cause air flue or dyspneic other diseases patient, gestation or women breast-feeding their children and merge the serious primary disease such as liver, kidney hemopoietic system and psychotic, those who are allergic to this drug and do not meet diagnostic criteria and not by regulation medication, the patient that curative effect or data are incomplete cannot be judged.
Therapeutic Method: matched group: oral decoction I, every day 2 times, each 100ml.Experimental group: oral decoction II, every day 2 times, each 100ml.Two groups was all 1 course for the treatment of with 6 months, 2 courses for the treatment of of continuous Ureteral Calculus.If there is bronchial asthma in acute attack in therapeutic process, all give conventional therapy, enter after the catabasis until stable disease, continue such scheme treatment.
Evaluation index: symptoms of asthma complete incidence graph: even have mild episode, medication is not needed to alleviate, sports can be done, night is asymptomatic, can to stop using completely glucocorticoid and bronchodilator, continue more than 0.5a, the 1st second forced expiratory volume (FEV) predicted value >=80% after treatment.Effective: symptoms of asthma obviously alleviates, feasible daily routines and light moderate physical work, can not join into sports; inhaled 12.5Mg/d, occasionally need suck Wan Tuolin aerosol, monthly be no more than 3 times; continue more than 0.5a, after treatment, FEV reaches predicted value 60% ~ 77%.Take a turn for the better: symptoms of asthma alleviates to some extent, can be engaged in light physical labor, can not to join into sports, middle heavy physical labour, inhaled 125Mg/d ~ 250Mg/d, monthly suck Wan Tuolin >3, continue more than 0.5a, after treatment, FEV increase weighs 15% ~ 24%.Invalid: symptom and FEV invalid or increase the weight of.
Shown in clinical efficacy statistical result sees the following form:
Table 1 liang group Clinical efficacy comparison
| Group | Number of cases | Complete incidence graph | Effective | Take a turn for the better | Invalid |
| Matched group | 40 | 7 | 18 | 13 | 2 |
| Experimental group | 40 | 8 | 20 | 12 | 0 |
Found out by table 1; experimental group is better than matched group; namely the decoction II that the inventive method is made is taken; its curative effect is better than decoction I; method of the present invention is adopted not only not reduce drug effect; and better efficacy, this also illustrates that fresh flos materia medica prepared according to the methods of the invention is exempted from fried dose of its drug effect and maintained better, and active component obtains protection preferably and extracts.
Above-mentioned clinical research can obviously be found out, fresh flos materia medica prepared by the present invention is exempted from fried dose and can be applied to and prepare compound preparation, namely the Chinese medicine recurrence comprising fresh flos materia medica can be prepared into liquid preparation, its preparation method can consult above-mentioned record herein; Same, according to record of the present invention, the Chinese medicine compound comprising fresh flos materia medica can be prepared into required preparation type by those skilled in the art, as tablet, capsule, injection, powder, unguentum, granule, pill, do not enumerate in this application, and the curative effect being better than conventional direct decoction gained Chinese medicine preparation can be obtained.
Claims (6)
1. fresh flos materia medica exempts from the preparation method of fried dose, it is characterized in that, comprises the following steps:
1) by fresh flos materia medica trickle cleaning surface impurity, slight oscillatory removes surface moisture, then drops in the broken centrifugal device of specialized high-speed and processes, obtain fluidised form medical material;
2) the fluidised form medical material that taking-up step 1) obtains is placed in reactor, add the water of its volume 3 ~ 8 times, reactor is airtight, adopt ultrasonic-microwave associated treatment, holding temperature is 12 ~ 15 DEG C, is filtered by the fluidised form medical material after process, obtains filtrate and filtering residue, filtering residue is proceeded to step 1) reprocessing, filtrate then proceeds to step 3);
3) in step 2) add ethanol in gained filtrate, make the volume fraction of ethanol reach 70 ~ 75%, 2 ~ 8 DEG C leave standstill 8 ~ 10h, get supernatant liquid, reclaim ethanol, being concentrated into relative density is 1.08 ~ 1.13(75 ~ 80 DEG C) mastic, dry, micronizing, sterilizing, obtains fresh flos materia medica and exempts from fried dose.
2. fresh flos materia medica as claimed in claim 1 exempts from the preparation method of fried dose, it is characterized in that: the broken centrifugal device of described specialized high-speed, comprise container containing, centrifuge container, broken cutting mechanism, controlling organization, motor and scraping mechanism, described motor is connected with controlling organization, described container containing is arranged on the outside of centrifuge container, described broken cutting mechanism is arranged in centrifuge container, and drive with motor and be connected, the blade that described broken cutting mechanism comprises rotating shaft and is connected with described rotating shaft, described blade is around described shaft circumference Heterogeneous Permutation, the inwall of described centrifuge container arranges the catch to described centrifuge container bottom angled, the wall of described centrifuge container arranges the filter opening communicated with described container containing, described filter opening flare structure, large mouth is towards the inside of described centrifuge container, the top of described centrifuge container arranges charging aperture, the bottom of described container containing arranges discharging opening, between described container containing and centrifuge container, scraping mechanism is set.
3. fresh flos materia medica as claimed in claim 1 exempts from the preparation method of fried dose, it is characterized in that: step 2) described in the process conditions of ultrasonic-microwave associated treatment be: ultrasonic power 150 ~ 300W, microwave power 230 ~ 380W, extraction time 5 ~ 10min, number of repetition 2 ~ 5 times, each interval is no less than 5 minutes.
4. fresh flos materia medica as claimed in claim 1 exempts from the preparation method of fried dose, it is characterized in that: dry for described mastic is carried out lyophilization described in step 3).
5. fresh flos materia medica as claimed in claim 4 exempts from the preparation method of fried dose, it is characterized in that: micronizing described in step 3) is, through super micron mill, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75Mm.
6. fresh flos materia medica prepared by the preparation method as described in any one of claim 1 ~ 5 exempts from the application of fried dose, it is characterized in that: described fresh flos materia medica is exempted from fried dose and directly adds in compound preparation, make pharmaceutically acceptable dosage form, comprise liquid preparation, granule, tablet, capsule, injection, powder, unguentum, pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN109206534A (en) * | 2018-11-05 | 2019-01-15 | 西藏农牧学院 | Blackfungus polyhexose mentions taking device |
| CN109206534B (en) * | 2018-11-05 | 2021-02-26 | 西藏农牧学院 | Device for extracting auricularia auricula polysaccharide |
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Application publication date: 20151223 |