CN105147942A - Granules for treating liver cirrhosis - Google Patents
Granules for treating liver cirrhosis Download PDFInfo
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- CN105147942A CN105147942A CN201510590989.0A CN201510590989A CN105147942A CN 105147942 A CN105147942 A CN 105147942A CN 201510590989 A CN201510590989 A CN 201510590989A CN 105147942 A CN105147942 A CN 105147942A
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Abstract
The invention belongs to the field of traditional Chinese medicines and discloses granules for treating liver cirrhosis. The granules are prepared by extracting the following traditional Chinese medicines in parts by weight: 20 parts of herb of threeflower bluebeard, 25 parts of root of ground cotoneaster, 18 parts of acanthus ilicifolius, 25 parts of rubustephrodes hance, 18 parts of tuckahoe, 25 parts of European berbena, 20 parts of root of meadowrue corydalis, 25 parts of Chinese thorowax root, 22 parts of Chinese angelica, 20 parts of danshen root, 15 parts of Chinese yam, 20 parts of tangerine peel, 15 parts of kudzuvine root, 25 parts of sweet wormwood herb, 15 parts of stringy stonecrop herb, 25 parts of radish seed, 20 parts of rehmannia root, 15 parts of codonopsis pilosula, 20 parts of figwort root, 15 parts of coptis root and 5 parts of licorice root. The granules can be used for treating the liver cirrhosis.
Description
Technical field
The present invention relates to a kind of Chinese medicine, particularly relate to one and treat liver cirrhosis granule.
Background technology
Liver cirrhosis is clinical common chronic progressive external hepatopathy, the diffusivity hepatic injury that long-term or repeated action is formed by one or more causes of disease.In China, great majority are posthepatitic cirrhosis, and small part is alcoholic cirrhosis and Cirrhosis In Schistosomiasis.Histopathology there are hepatic necrosis, the regeneration of remaining liver cell nodules, connective tissue proliferation and fiber widely every formation, cause lobules of liver structural deterioration and pseudolobuli formation, liver is out of shape gradually, hardening and develop into liver cirrhosis.In early days because liver compensation more by force can non-evident sympton, stage with liver function injury and portal hypertension for main manifestations, and have multisystem to get involved, often there is the complication such as upper gastrointestinal hemorrhage, hepatic encephalopathy, secondary infection, hypersplenism, ascites, canceration late period.Cause the cause of disease of liver cirrhosis a lot, viral hepatitis liver cirrhosis, alcoholic cirrhosis, metabolic liver cirrhosis, Cholestatic cirrhosis, hepatic vein backflow obstruction liver cirrhosis, autoimmune cirrhosis, poisonous substance and drug induced liver cirrhosis, nutritional cirrhosis, cryptogenic cirrhosis etc. can be divided into.The effect of current treatment product liver cirrhosis is all not so good, is therefore badly in need of a kind of Chinese medicine for the treatment of liver cirrhosis.
Summary of the invention
Goal of the invention: the object of the present invention is to provide one to treat liver cirrhosis granule and preparation method thereof.
Technical scheme: one treats liver cirrhosis granule, is prepared from by the Chinese medicine extraction of following weight parts: Herba Caryopteridis Terniflorae 20 parts, Radix Cotoneastri Perpusillae 25 parts, old Mus le 18 parts, Wu Pao sting 25 parts, 18 parts, Poria, Herba Verbenae 25 parts, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 20 parts, Radix Bupleuri 25 parts, Radix Angelicae Sinensis 22 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Dioscoreae 15 parts, Pericarpium Citri Reticulatae 20 parts, Radix Puerariae 15 parts, Herba Artemisiae Annuae 25 parts, Herba Sedi 15 parts, Semen Raphani 25 parts, Radix Rehmanniae 20 parts, Radix Codonopsis 15 parts, Radix Scrophulariae 20 parts, Rhizoma Coptidis 15 parts, 5 parts, Radix Glycyrrhizae.
Described treatment liver cirrhosis granule, preparation method: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch, granulate, make granule.
The application of described treatment liver cirrhosis granule in preparation treatment liver cirrhosis granule.
Herba Caryopteridis Terniflorae is Yichang Zlatostema involucratum Franch. Et savat. (ElatostemaichangenseH.Schroter), Urticaceae perennial herb.Spend in vain because its lunar calendar is opened June, normal growth in flakes, just as high mountain accumulated snow, to people's nip in the air, therefore this name.Effect of this medical instrument cold expelling, eliminate indigestion, blood stasis dispelling, detumescence.Deliver cold expelling, lung qi dispersing cough-relieving, promoting blood flow to regulate menstruation.For cold cough, liver cirrhosis, pertussis, stimulates the menstrual flow, puerperal abdonimal pain; Knife injury is controlled in external, burn and scald, venom.
Radix Cotoneastri Perpusillae is the root that rosaceous plant lobule puts down a Fructus Cotoneastri Acutifolii.The whole year can adopt.Cool in nature, sour-puckery flavor.Removing damp-heat.
Lao Shu le, formal name used at school: Acanthusilicifolius is the plant that the Lao Shu le of Acanthaceae belongs to.Be distributed in the ground such as the Fujian of China's Mainland, Hainan, Guangdong, be born in tide energy area, seashore or area, beach, at present not yet by artificial introducing and planting more.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, relieving cough and asthma.For lymphadenectasis, acute hepatitis, chronic hepatitis, hepatosplenomegaly, stomachache, cough, asthma.The present invention adopts all herbal medicine.
Wu Pao thorn is Rosaceae rubus Rubus tephrodes RubustephrodesHance, is used as medicine with root, leaf and seed.Picking leaves in summer, adopt root and seed autumn, dry, the present invention is used as medicine with leaf.Root: expelling wind and removing dampness, promoting blood flow to regulate menstruation.For rheumatalgia, chronic hepatitis, diarrhoea, dysentery, traumatic injury, menoxenia.Leaf: hemostasis, removing toxic substances.Traumatic hemorrhage is controlled in external, carbuncle furuncle infections.Seed: QI invigorating benefit essence.For body is empty after being ill, neurasthenia.Other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, liver cirrhosis disease belongs to be gathered, how because of parasitosis infect, tobacco and wine are immoderate, diet is uncomfortable, caused by feelings god internal injury, his sick delay, ascites is gathered, and qi depression to blood stasis forms.Herba Caryopteridis Terniflorae of the present invention, Radix Cotoneastri Perpusillae, old Mus le, Wu Pao thorn, Poria, Herba Verbenae, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Radix Bupleuri, Radix Angelicae Sinensis heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating are monarch drug, Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Radix Puerariae, Herba Artemisiae Annuae, Herba Sedi, Semen Raphani, Radix Rehmanniae, Radix Codonopsis, Radix Scrophulariae, Rhizoma Coptidis blood circulation promoting and blood stasis dispelling, the liver soothing and the spleen invigorating are ministerial drug, Radix Glycyrrhizae is adjuvant, heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, the liver soothing and the spleen invigorating, full side treats liver cirrhosis, respond well.
Detailed description of the invention
Embodiment 1: get Herba Caryopteridis Terniflorae 20g, Radix Cotoneastri Perpusillae 25g, Lao Shu le 18g, Wu Pao stings 25g, Poria 18g, Herba Verbenae 25g, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 20g, Radix Bupleuri 25g, Radix Angelicae Sinensis 22g, Radix Salviae Miltiorrhizae 20g, Rhizoma Dioscoreae 15g, Pericarpium Citri Reticulatae 20g, Radix Puerariae 15g, Herba Artemisiae Annuae 25g, Herba Sedi 15g, Semen Raphani 25g, Radix Rehmanniae 20g, Radix Codonopsis 15g, Radix Scrophulariae 20g, Rhizoma Coptidis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
Embodiment 2: the present invention treats the clinical data of liver cirrhosis
Clinical medicine: prepare granule of the present invention by above-described embodiment 1, when taking each 1 bag, every bag of 20g, every day 3 times 30 days is a course for the treatment of.The routine patient of clinical observation 60.
Diagnostic criteria:: (1) scope or esophagus gulp down the inspection of barium x-ray and find esophageal varicosis.(2) B ultrasonic prompting liver echo obviously strengthens, and inequality, luminous point are thick; Or liver surface owes smooth, uneven or indentation; Or portal vein diameter >=1.4cm; Or spleen increases, splenic vein diameter >=1.0cm.(3) ascites, companion's vena epigastrica anger is opened.(4) CT shows liver outer rim nodositas protuberance, and fissure expands, caudal lobe/lobus dexter ratio > 0.05, splenomegaly.(5) peritoneoscope or needle biopsy of liver are examined as liver cirrhosis.More than except (5), the secondary indication of other any one bound fractions, can make a definite diagnosis.Secondary indication: (1) chemically examines: (A/G is inverted general abnormal liver function, protein electrophoresis A reduces, gamma Globulin raises, serum bilirubin raises, prolonged prothrombin etc.), or Serum hyaluronic acid (HA), III procollagen type Ⅲ (P III P), ammoxidation single enzyme (MAO), ADA Adenosine deaminase (ADA), flaggy element (LN) increase: (2) sign: hepatic facies (face is dark dim simple and unadorned), visible multiple spider angioma, color is dim, liver palm, jaundice, lower limbs edema, Liver on Judge Hardness is partially hard, splenomegaly, gynaecomastia.More than chemically examine and listed by sign, need not know standby.
Observation of curative effect: recovery from illness: the patient's ascites, the jaundice that reach clinical cure disappear completely, clinical symptom disappearance or substantially disappear, liver spleen obviously bounces back deliquescing or stablize constant, and liver function recovery is normal, and muscle power is obviously recovered, and drug withdrawal was not all recurred in later six months.Effective: to treat effective patient's ascites, jaundice disappears, main clinic symptoms disappears, and muscle power is obviously recovered, and liver spleen is stablized constant, liver function also be improved significantly, if there is recurrence in the patient half a year after healing, be also considered to effective.Effective: after treatment, the ascites of patient, jaundice obviously disappear, clinical symptom relief, and liver function improves, represent cirrhosis treatment Results.Invalid: after accepting Canonical management two weeks, the symptom of patient, sign, liver function are all not improved, even occur to worsen further or dead, prompting is failed to respond to any medical treatment.
Result: recovery from illness 18 example, effective 23 examples, effective 12 examples, invalid 7 examples, total effective rate 88.3%, and have no side effect.
Claims (3)
1. a treatment liver cirrhosis granule, it is characterized in that, be prepared from by the Chinese medicine extraction of following weight parts: Herba Caryopteridis Terniflorae 20 parts, Radix Cotoneastri Perpusillae 25 parts, old Mus le 18 parts, Wu Pao sting 25 parts, 18 parts, Poria, Herba Verbenae 25 parts, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 20 parts, Radix Bupleuri 25 parts, Radix Angelicae Sinensis 22 parts, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Dioscoreae 15 parts, Pericarpium Citri Reticulatae 20 parts, Radix Puerariae 15 parts, Herba Artemisiae Annuae 25 parts, Herba Sedi 15 parts, Semen Raphani 25 parts, Radix Rehmanniae 20 parts, Radix Codonopsis 15 parts, Radix Scrophulariae 20 parts, Rhizoma Coptidis 15 parts, 5 parts, Radix Glycyrrhizae.
2. treat liver cirrhosis granule as claimed in claim 1, it is characterized in that, preparation method: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch, granulate, make granule.
3. treat the application of liver cirrhosis granule in treatment liver cirrhosis granule as claimed in claim 1.
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103055285A (en) * | 2012-12-26 | 2013-04-24 | 柳州市中医院 | Traditional Chinese medicine for treating forepart hepetocirrhosis and preparation method thereof |
CN104888144A (en) * | 2015-06-26 | 2015-09-09 | 徐国华 | Pharmaceutical preparation used for curing liver cirrhosis |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103055285A (en) * | 2012-12-26 | 2013-04-24 | 柳州市中医院 | Traditional Chinese medicine for treating forepart hepetocirrhosis and preparation method thereof |
CN104888144A (en) * | 2015-06-26 | 2015-09-09 | 徐国华 | Pharmaceutical preparation used for curing liver cirrhosis |
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