CN105126035A

CN105126035A - White paeony root health care oral solution capable of nourishing blood and liver and preparation method thereof

Info

Publication number: CN105126035A
Application number: CN201510654956.8A
Authority: CN
Inventors: 孙霞
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Qingdao Hengbo Instrument Co Ltd
Priority date: 2015-10-12
Filing date: 2015-10-12
Publication date: 2015-12-09

Abstract

The invention discloses a white paeony root health care oral solution capable of nourishing blood and liver. The health care oral solution is prepared from, by weight, 10-50 parts of white paeony roots, 10-20 parts of medlar, 10-20 parts of the roots of red-rooted salvia, 10-20 parts of polygala tenuifolia, 10-20 parts of poria cocos, 10-20 parts of rhizoma cyperi, 10-20 parts of radices trichosanthis, 10-20 parts of curcuma aromatic, 10-20 parts of roots of rehmannia, 10-20 parts of fructus rosae laevigatae, 10-20 parts of gynostemma pentaphylla, 10-20 parts of lalang grass rhizome, 10-20 parts of leonurus, 10-20 parts of gardenia, 10-20 parts of mulberries, 10-20 parts of sealwort and 10-20 parts of caulis spatholobi. The traditional Chinese medicine has indicated that the women take blood nourishing as the foundation. The modern nutriology theory and the traditional Chinese medicine health care theory are organically combined, free radicals can be removed, regeneration of live cells is promoted, the blood is replenished, the liver is nourished, the liver is calmed, pain is relieved, yin is retained and sweat is received; diseases such as fever due to deficiency of yin, irregular menstruation and abdominal pain diarrhea can be treated, qi and blood are nourished, and whitening and freckle removal are achieved.

Description

Radix Paeoniae Alba health care oral liquid of a kind of nourishing blood to suppress the hyperactive liver and preparation method thereof

Technical field

The present invention relates to the medical health product containing deriving from plant, animal or raw mineral materials, Radix Paeoniae Alba health care oral liquid of particularly a kind of nourishing blood to suppress the hyperactive liver and preparation method thereof.

Background technology

Human body is " flesh and blood ".Only have hemapodium, just seem that skin is ruddy, face is glossy; Only have meat real, just can have muscular, build is vigorous and graceful.For women, pursue face gorgeous, stature is gentle and graceful, should focus on and nourish blood.Woman's Yangxuemeiyan achieves gentle and graceful stature has due to female pathology the feature that " cycle " hematozemia is many, sets up their relationship with blood.Chinese medicine is pointed out for a long time: " women is to nourish blood as this." if women is bad to nourish blood, just easily occur that shallow complexion, lip and nail are pale, limb is puckery, dried and withered hairs, dizziness, dim eyesight, the Blood deficiency such as weak, out of breath, i.e. anemia.The senilism symptom such as wrinkle, poliosis, debentition also occur severe anemia person very easily too early, walk haltingly.Visible, women nourishes blood extremely urgent.So, how woman should carry out nourishing blood enriching blood.The traditional Chinese medical science thinks that the liver being in charge of the eyes: " liver-QI being connected with eyes, liver and then order can distinguish the five colors ".The pathological changes of liver often affects and order.As deficiency of liver-blood, then two dryness and uneasy feeling of the eye, blurring of vision or nyctalopia; Wind-heat of liver channel, visible conjunctival congestion is itched bitterly; Flaming up of liver-fire, visible keratoconjunctivitis; Excessive rising of liver-YANG, the then vertigo; Liver-wind stirring up internally, looks on visible order is oblique.

Liver controlling conveyance and dispersion, the general reference comprehensive physiological functions such as irritability has dredging, bar reaches, liter is sent out, freely let out.Ancients rush with wood gas the catharsis function resembling analogy liver with bar soothing the liver, therefore are belonged to wood in the five elements, therefore " the secret allusion quotation opinion of Plain Questions LINGLAN " is said: " liver person; organ of general considers and here ", " Plain Questions six saves state of internal organs opinion " is said: " liver person; source of endurance, the residence of soul also ".The function of liver controlling conveyance and dispersion is mainly manifested in and regulates spiritual feelings will, and facilitating digestion absorbs, and maintains operation three aspect of QI and blood, body fluid.

The Radix Paeoniae Alba is the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae (cultigen).Its root is thick thick sturdy, is traditional Chinese crude drug.The Radix Paeoniae Alba is cold, bitter in the mouth acid, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receive the effect such as antiperspirant, can treat the diseases such as fever due to yin deficiency, menoxenia, dysentery stomachache, can also invigorating qi and benefiting blood, whitening and speckle dispelling.

The Radix Paeoniae Alba is nourished blood and seeks; Relieving spasm to stop pain; Effect of yin fluid astringing suppressing the hyperactive liver; The Radix Paeoniae Alba cures mainly menoxenia; Abdominal pain during menstruation; Metrorrhagia; Spontaneous perspiration; Night sweat; Side of body rib epigastric pain; Limb pain twin; Headache; Dizzy, the Radix Paeoniae Alba has protecting the liver, falls the effect of enzyme, the compatibilities such as normal and Radix Bupleuri, Radix Angelicae Sinensis, Radix Rehmanniae, the Radix Paeoniae Alba also has the effect such as immunity moderation, antiinflammatory, and clinical treatment chronic gastritis, peptic ulcer, chronic enteritis, irritable colon syndrome, acute icterohepatitis, chronic hepatitis B, hepatic fibrosis and liver cirrhosis, treatment sciatica, headache, epilepsy, coronary heart disease, rheumatoid arthritis have certain effect.Effect of the Radix Paeoniae Alba and effect mainly antibacterial pain relieving, can depressed liver-energy dispersing and QI regulating, easing the affected liver nourish blood, slow in pain relieving, suppressing the hyperactive liver yin fluid astringing, be usually used in the distending pain in the chest and hypochondrium caused by incoordination between the liver and stomach, epigastric pain.

The Radix Paeoniae Alba is applicable to people's breast abdomen pain over the hypochondriac region of the blood deficiency deficiency of YIN, pain in the hepatic region, and cholecystitis gallstones pain person should eat; Dysentery is suffered from abdominal pain, and women's menalgia person should eat; Spontaneous perspiration easy antiperspirant night sweat person should eat; Sural spasm, spasm of the limbs pain, uneasy lower limb syndrome patients should eat; Coordinate with alleviating various breast abdomen and limbs pain with Radix Glycyrrhizae.But the Radix Paeoniae Alba is cold in nature, the deficient cold type stomachache person of having loose bowels diet; Diet during children's suffers from measles; Take Chinese medicine Rhizoma et radix veratri (Radix Rhizoma Veratri) person diet.

The Radix Paeoniae Alba, containing paeoniflorin, paeonol, paeoniflorin, still contains benzoic acid, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes etc.

The Radix Paeoniae Alba is cool in nature, and bitter in the mouth acid, is slightly cold, has the effects such as blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.

Paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.

The medical mechanism of the Radix Paeoniae Alba:

1. piece containing paeoniflorin, paeonol, paeoniflorin, benzoic acid about 1.07%, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes.Another Sichuan product person, containing a kind of acidic materials, has inhibitory action to staphylococcus aureus.

2. flower is containing astragalin, nimbecetin 3,7-diglucoside, volume gallotannin (more than 10%), pyrethrin 0.13%, 13-base tetradecanoic acid, cupreol, pentacosane etc., and leaf is containing tannin.

3. the Radix Paeoniae Alba contains paeoniflorin (Paeoniflorin), paeonol (Paeonol), paeoniflorin (Paeonin). also containing benzoylpaeoniflorin (Benzoylpaeoniflorin), Albiflorin (Albiflorin), oxypaeoniflorin (Oxypaeoniflorin), the lucky ketone (Paeoniflorigenone) of Radix Paeoniae. still containing benzoic acid (Benzoicacid), cupreol (β-Sitosterol), gallotannin (Gal-lotannin) etc.In addition, also containing volatile oil, fatty oil, resin, sugar, starch, lymphatic temperament, protein and triterpenes components.

4. antiinflammatory action experiment shows: white peony root's total glycoside has obvious preventive and therapeutic effect to rat assist agent arthritis, rat peritoneal macrophages can be made to produce too much hydrogen peroxide and interleukin-1 level decline, and the ability that thymus NK cell activity low caused by rat assist agent arthritis and splenocyte can be made to produce interleukin II recover normal simultaneously.Prompting white peony root's total glycoside has antiinflammatory and function dependency ground immunoregulation effect to adjuvant arthritis rats.Radix Paeoniae Alba extract significantly can suppress rat Ovum Gallus domesticus album acute inflammation edema, granuloma induced by implantation of cotton pellets is also had to the effect suppressing its hypertrophy.

5. pair immune Effect study shows: the phagocytic function of the Radix Paeoniae Alba to macrophage has potentiation.Every day with the Radix Paeoniae Alba water decoction 0.8ml/ of 50% only raises to mice, and continuous 5 days, the phagocytic percentage of Turnover of Mouse Peritoneal Macrophages and phagocytic index all comparatively matched group were significantly improved.Every day to mouse stomach, also can promote the phagocytic function of its peritoneal macrophage with white peony root's total glycoside 40mg/kg.

Experiment proves: the phagocytic function of white peony root's total glycoside to peritoneal macrophage has regulating action; White peony root's total glycoside produces interleukin-1 to lipopolysaccharide-induced rat peritoneal macrophages and has the effect that low concentration promotes and high concentration suppresses, because interleukin-1 all plays an important role in the formation of immunomodulating and chronic inflammation disease, therefore can think, white peony root's total glycoside regulates the generation of interleukin-1 may be that it plays immunomodulating and prevents and treats one of arthritic mechanism.

Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.How the efficacy exertion of the Radix Paeoniae Alba not being injured human body again to maximum, and obviously improve mouthfeel, people can be accepted, is our problem in the urgent need to address.Human body is " flesh and blood ".Only have hemapodium, just seem that skin is ruddy, face is glossy, and only have meat real, just can have muscular, build is vigorous and graceful.For women, pursue face gorgeous, stature is gentle and graceful, should focus on and nourish blood.Woman's Yangxuemeiyan achieves gentle and graceful stature has due to female pathology the feature that " cycle " hematozemia is many, sets up their relationship with blood.Chinese medicine is pointed out for a long time: " women is to nourish blood as this." if women is bad to nourish blood, just easily occur that shallow complexion, lip and nail are pale, limb is puckery, dried and withered hairs, dizziness, dim eyesight, the Blood deficiency such as weak, out of breath, i.e. anemia.The senilism symptom such as wrinkle, poliosis, debentition also occur severe anemia person very easily too early, walk haltingly.Visible, women nourishes blood extremely urgent.So, how should woman carry out nourishing blood enriching blood? the Radix Paeoniae Alba is cold, bitter in the mouth acid, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receive the effect such as antiperspirant, can treat the diseases such as fever due to yin deficiency, menoxenia, dysentery stomachache, can also invigorating qi and benefiting blood, whitening and speckle dispelling.Chinese medicine health care product has advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.

Summary of the invention

Technical problem to be solved by this invention is, Chinese medicine is pointed out for a long time: " women is to nourish blood as this." if women is bad to nourish blood, just easily occur that shallow complexion, lip and nail are pale, limb is puckery, dried and withered hairs, dizziness, dim eyesight, the Blood deficiency such as weak, out of breath, i.e. anemia.The senilism symptom such as wrinkle, poliosis, debentition also occur severe anemia person very easily too early, walk haltingly.Visible, women nourishes blood extremely urgent.So, how should woman carry out nourishing blood enriching blood? in view of the traditional Chinese medical science has the characteristic of dialectical treatmert, the advantage that Chinese medicine toxic side effect is little, Chinese medicine health-care treatment causes extensive concern.The Radix Paeoniae Alba is cold, bitter in the mouth acid, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receive the effect such as antiperspirant, can treat the diseases such as fever due to yin deficiency, menoxenia, dysentery stomachache, can also invigorating qi and benefiting blood, whitening and speckle dispelling.The present invention organically combines theoretical for modern nutriology with Chinese Traditional Medicine health care theory, can scavenging free radicals, promote hepatocellular regeneration, enrich blood easing the affected liver, suppressing the hyperactive liver pain relieving, yin fluid astringing receives the effect such as antiperspirant, the diseases such as fever due to yin deficiency, menoxenia, dysentery stomachache can be treated, can also invigorating qi and benefiting blood, whitening and speckle dispelling.

For solving the problems of the technologies described above, the invention provides a kind of Radix Paeoniae Alba health care oral liquid of nourishing blood to suppress the hyperactive liver, described health care oral liquid comprises the crude drug of following parts by weight: the Radix Paeoniae Alba 10 ~ 50 parts, Fructus Lycii 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Rhizoma Cyperi 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Fructus Rosae Laevigatae 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Flos Gardeniae 10 ~ 20 parts, 10 ~ 20 parts, Fructus Mori, Rhizoma Polygonati 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts.

The Radix Paeoniae Alba health care oral liquid of described nourishing blood to suppress the hyperactive liver, the parts by weight of health care oral liquid crude drug described in it can be: the Radix Paeoniae Alba 10 ~ 30 parts, Fructus Lycii 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Radix Polygalae 10 ~ 15 parts, 10 ~ 15 parts, Poria, Rhizoma Cyperi 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, Radix Curcumae 10 ~ 15 parts, 10 ~ 15 parts, the Radix Rehmanniae, Fructus Rosae Laevigatae 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Flos Gardeniae 10 ~ 20 parts, 10 ~ 20 parts, Fructus Mori, Rhizoma Polygonati 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts.

The Radix Paeoniae Alba health care oral liquid of described nourishing blood to suppress the hyperactive liver, the parts by weight of health care oral liquid crude drug described in it can also be: the Radix Paeoniae Alba 10 ~ 40 parts, Fructus Lycii 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Rhizoma Cyperi 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Fructus Rosae Laevigatae 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, Rhizoma Imperatae 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Flos Gardeniae 10 ~ 15 parts, 10 ~ 15 parts, Fructus Mori, Rhizoma Polygonati 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Radix Paeoniae Alba health care oral liquid of nourishing blood to suppress the hyperactive liver, and described in it, the preparation process of health care oral liquid comprises:

A. the preparation of the Radix Paeoniae Alba, as component 1;

B. all the other crude drug described are put into ethanol heating and refluxing extraction 2 times, as component 2;

C. by above-mentioned two kinds of extracting solution components 1 and component also 2-in-1, add dextrin after concentrated and be in harmonious proportion, after disinfection, be prepared into health oral liquor.

In described step a, can in autumn time the Chinese herbaceous peony root of Radix Paeoniae Alba is all dug, excision bud head, cleans earth, and well-done with boiling water respectively by thickness is degree, and add the water yield to flood Chinese herbaceous peony root for degree, boiling time is determined according to Chinese herbaceous peony root thickness, to Chinese herbaceous peony root without the white heart as well; Let cool in water after pulling out and slightly soak, take out, scrape off crust, immediately dry in the sun.

In described step a, comprise further, the Radix Paeoniae Alba that dry in the sun is good is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.

In described step b, the medicine of all the other crude drug can be put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then puts into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 80 DEG C 1.06 extractum, become component 2.

In described step c, can by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.36, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method of Radix Paeoniae Alba health care oral liquid of nourishing blood to suppress the hyperactive liver, and its preparation process can also be:

A. the preparation of the Radix Paeoniae Alba, as component 1;

B. all the other crude drug described soaked, extract 3 times as component 2;

C. component 1 and component 2 are mixed, add proper honey after concentrated and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

In described step b, all the other crude drug can be soaked in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge lixiviating solution, being condensed into pasty state becomes component 2.

The present invention organically combines theoretical for modern nutriology with Chinese Traditional Medicine health care theory, can scavenging free radicals, and promote hepatocellular regeneration, Chinese medicine is pointed out for a long time: " women with nourish blood for." if women is bad to nourish blood, just easily occur that shallow complexion, lip and nail are pale, limb is puckery, dried and withered hairs, dizziness, dim eyesight, the Blood deficiency such as weak, out of breath, i.e. anemia.The senilism symptom such as wrinkle, poliosis, debentition also occur severe anemia person very easily too early, walk haltingly.Visible, women nourishes blood extremely urgent.The advantage that Chinese medicine toxic side effect is little, Chinese medicine health-care treatment causes extensive concern.The Radix Paeoniae Alba is cold, bitter in the mouth acid, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receive the effect such as antiperspirant, can treat the diseases such as fever due to yin deficiency, menoxenia, dysentery stomachache, can also invigorating qi and benefiting blood, whitening and speckle dispelling.The present invention organically combines theoretical for modern nutriology with Chinese Traditional Medicine health care theory, can scavenging free radicals, promote hepatocellular regeneration, enrich blood easing the affected liver, suppressing the hyperactive liver pain relieving, yin fluid astringing receives the effect such as antiperspirant, the diseases such as fever due to yin deficiency, menoxenia, dysentery stomachache can be treated, can also invigorating qi and benefiting blood, whitening and speckle dispelling.

Detailed description of the invention

Woman's health preserving allows and oneself becomes more healthy and beautiful, and many woman understand to be needed to maintain oneself by various mode after busy, but when taking action, we but usually easily go on wrong path.Woman wants health preserving, first thing be exactly from nourish blood and enrich blood s, color has been got well, women health just have talk.Woman maintain the first step be exactly with blood for because the menstruation of women, tire are pregnant, the physiological characteristics such as delivery and feed infant and suckling all easily consumes blood, so female organism is relatively easily in the state of blood system deficiency.Say as " a Ling Shu Miraculous Pivot or Divine Axis five flavours and five notes of traditional Chinese music section ": " life of women, has a surplus in gas, be not enough to blood, with its number collapse due to massive hemorrhage also." so, first female health preserving should be paid attention to maintaining QI and blood.Hemapodium just can make to have rosy cheeks beautiful, menses normal, spirit is vigorous.Nourish blood if be bad at, just easily occur that shallow complexion is simple and unadorned, lip and nail are pale, dizziness and blurred vision, fatigue and weakness, dried and withered hairs limb are numb, few through blood volume, delay in menstrual period, light red tongue thready pulse etc.During severe anemia, also easily occur wrinkle early raw, grey hair early white, climacteric the premature exhaustion such as in advance.

Women has because of its physiology the feature that cycle hematozemia is many, nourishes blood if be bad at, just easily occur that shallow complexion, lip and nail are pale, limb is puckery, dried and withered hairs, dizziness, dim eyesight, the Blood deficiency such as weak, out of breath.Severe anemia person, the senilism symptom such as wrinkle, poliosis, debentition also occur very easily too early, walk haltingly.Hemapodium, skin could be ruddy, and complexion is just glossy, women is beautiful to pursue face, stature is gentle and graceful, must pay attention to nourishing blood, and nourishes blood, and note the following aspects: god reposes foster happy, have a bright and cheerful disposition, not only can promote the immunity of body, and be conducive to physical and mental health, can also promote that the hemopoietic function of bone marrow in health skeleton is vigorous simultaneously, make skin ruddy, face is glossy.So, the emotion that should often keep pleasant.

The traditional Chinese medical science thinks that the liver being in charge of the eyes: " liver-QI being connected with eyes, liver and then order can distinguish the five colors ".The pathological changes of liver often affects and order.As deficiency of liver-blood, then two dryness and uneasy feeling of the eye, blurring of vision or nyctalopia; Wind-heat of liver channel, visible conjunctival congestion is itched bitterly; Flaming up of liver-fire, visible keratoconjunctivitis; Excessive rising of liver-YANG, the then vertigo; Liver-wind stirring up internally, looks on visible order is oblique.

Fructus Lycii mainly containing betanin, carotene, ascorbic acid, linoleic acid, have the aminoacid of tens kinds of needed by human such as aspartic acid, glutamic acid, methionine, taurine, and be rich in the trace element of the multiple needed by human such as calcium Ca, ferrum Fe, zinc Zn, selenium Se, vitamin B1, vitamin B2, vitamin C.Folium Lycii tea has and alleviates frigidity, stomach invigorating, liver protecting and kidney invigorating, suppresses pulmonary tuberculosis, eliminates constipation, relieving insomnia, and conditioning hypotension, anemia, treat various ophthalmic and oral inflammation, and can skin-protecting face nursing.Long-term drink, to treat body constitution deficiency and coldness, can build up resistance especially, can play the effect of certain improvement body constitution.Fructus Lycii has many effects, and aobvious author has three: heat clearing away, reduces blood pressure, and logical intestinal profit just.

Radix Polygalae is bitter, pungent, tepor.GUIXIN, kidney, lung meridian.Function cures mainly Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm, detumescence.For the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Be applied to insomnia and dreamful sleep, severe palpitation, forgetful.This product toil is warm in nature, property is kind lead off sensible, can happily gas and mind tranquilizing and the heart calming, kidney qi can be led to and strong will is not forgotten, be restoring normal coordination between the heart and kidney, stabilize mind, good merchantable brand that Fructus Alpiniae Oxyphyllae is known by force.Cure mainly the diseases such as the malaise of disarmony between the heart and kidney, insomnia, palpitation with fear, normal with Poria cum Radix Pini, Dens Draconis, Cinnabaris etc. the same use of medicinal for tranquilizing mind, as Radix Polygalae ball (" Zhang Shi doctor is led to "); Control forgetful card, normal and Radix Ginseng, Poria, the same use of Rhizoma Acori Graminei, as Kaixin San (" prescriptions worth thousand gold "), if Fang Zhongzai adds Poria cum Radix Pini, namely do not forget fall apart (" Standards of Diagnosis and Treatment ")." book on Chinese herbal medicine is just ": Radix Polygalae, the wholwe-hearted kidney of merit, therefore can relieving palpitation spasmolytic, the peace that exorcises evil spirits dream, Yang strengthening and life essence tonifying, strong will power-assisted.With its gas lift, thus same Radix Ginseng, Radix Glycyrrhizae, Semen Ziziphi Spinosae, pole can lift fall into consolidating semen, handing-over extreme misery

Herb Gynostemmae Pentaphylli finds through modern medicine study, Herb Gynostemmae Pentaphylli principle active component is polysaccharide, flavonoid, saponins and microelement kind, its effect mainly promotes body fat class substance metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in hyperlipidemia, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (pharyngolaryngitis, gastroenteritis etc.) and health care.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Radix Curcumae is pungent, bitter, cold.Return liver, the heart, lung meridian.Function cures mainly regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.Promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice." property of medicine opinion " carries it: control woman's stagnated blood epigastric pain caused by emotional factors, and cold air knot is poly-, and warm vinegar rubs and takes it.Tang Materia Medica carries it: main accumulation of blood, the therapeutic method to keep the adverse QI flowing downwards, granulation promoting, hemostasis, broken stagnant blood, stranguria with blood, hematuria, incised wound.

The pungent micro-hardship of Rhizoma Cyperi is sweet, and flat function cures mainly: resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type is suffered from abdominal pain, distending pain of the breast." detailed outline " carries it: loose seasonal epidemic pathogens is trembled with fear epidemic disease, and profit three is burnt, and separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, the moon wait uncomfortable, before tire puerperal all kinds of diseases and ailments.

Fructus Mori are sweet; Acid; Cold in nature, return through liver; Kidney channel, effect: nourishing YIN and supplementing blood; Promote the production of body fluid and moisturize.Cure mainly: having a dizzy spell of deficiency of the liver and kindey and blood deficiency damage of essence; Soreness of waist tinnitus; Early whitening of beard and hair; Insomnia and dreamful sleep; Tianjin wound is thirsty; Quench one's thirst; Dryness of the intestine constipation." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the dirty and controlling nocturnal emission with astringent drugs of kidney tonifying, takes hair color improving eyesight for a long time.5. " detailed outline ": smash juice drink, separate alcohol intoxication, wine brewing clothes, diuretic gas, detumescence.

Flos Gardeniae is cold in nature, sweet-bitter flavor; Enter lung, Liver Channel.Effect: clearing away lung-heat to relieve cough, cooling blood for hemostasis.Cure mainly cough due to lung-heat, nose, cough up phlegm, the diseases such as toxic swelling.Main component: Flos Gardeniae contains Triterpenoid, Fructus Gardeniae flower acid A, B and son acid.Containing volatile oil, comprise benzyl acetate, linalyl acetate, another containing pigment glycoside, C6H14O6 etc.In addition, also containing carbohydrate, protein, crude fibre and multivitamin.Clearing away heat and cooling blood, Flos Gardeniae bitter cold, able person's blood system and clear pathogen is warm is pyogenic infections from tumour or sore, hemorrhoidal hamorrhage dysentery, the auxiliary treatment food of the diseases such as bleeding due to blood-heat.2. preventing phlegm from forming and stopping coughing, the effective ingredient of Flos Gardeniae can bacteria growing inhibiting, releases sputum and unobstructed air flue, has effect of preventing phlegm from forming and stopping coughing, can be used as heat-phlegm and stops up and the dietetic therapy product that cause cough person.3. wide intestinal relieving constipation, anti-cancer, Flos Gardeniae contains cellulose, can promote intestinal peristalsis, helps the excretion of stool, the prevention outbreak of hemorrhoid and the generation of rectum carcinoma.

Rhizoma Imperatae cures mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing.For spitting blood, hematuria, pyretic stranguria, edema, jaundice, dysuria, calentura excessive thirst, gastric heat is vomitted the sound of vomiting, coughs." herbal classic ": " main impairment caused by overstrain void is won, invigorating the spleen and replenishing QI, except blood stasis, blood close cold and heat, diuresis." " not Lu ": " lower five types of stranguria, except exopathogenic heat is at the intestines and stomach, quenches the thirst, hard muscle, married woman's metrorrhagia.", " book on Chinese herbal medicine justice ": Rhizoma Imperatae, cold and cool and taste is very sweet, the heat that to purify the blood point, and do not hinder drying, not sticky again, therefore removing heat from blood and do not consider its long-pending stasis of blood, tell nosebleed hematemesis to lead.Drop-down fire is inverse, and its effect is very prompt, thus main stomach-fire hiccup vomiting again, lung-heat QI rising in reverse order dyspnea with fullness of the chest.And sweet cold and greasiness liquid, though sending down the abnormal ascending QI and differ from bitter dry, then slake thirst and help produce saliva again, and wash clearly the latent heat between lung gastrointestinal, can rapid digestion of food be treated yearningly dry.Again can treating stranguria closing and control hematuria hematochezia, and housewife female's bleeding due to blood-heat, metrorrhagia drenches band.The little water of tonneau again, the edema of the knot that expels the heat-evil, leads the jaundice of stagnant heat, all sweet cold actual effect of removing heat by catharsis.So its sweet cold power, lets out clearly lung stomach, especially has speciality, all toothache swelling of the gum, all skin ulcers of ulcerative gingivitis dispute, and the strongly fragrant pharyngalgia of stopping up of lung-heat is rotted all cards, and make in order to assistant, effect is the most outstanding, and without abuses.

Radix Trichosanthis, Chinese medicine name." book on Chinese herbal medicine justice ": medicine so-called Radix Trichosanthis person wantonly, namely cuts into slices with it with the root that withers, has the name of powder, real without powder.Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, and be clearing away heat-fire class medicine, its concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, and evacuation of pus is subsided a swelling.Cure mainly: control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.For treatment diabetes, conventional it and drugs for nourishing yin with the use of, to reach the effect for the treatment of both the principal and secondary aspects of a disease.

The Radix Rehmanniae, sweet, cold.GUIXIN, liver, kidney channel.There is clearing away heat and cooling blood, effect that tonifying YIN promotes the production of body fluid.To join the army blood for warm febrile disease, high fever coma, xerostomia crimson tongue, as qingying decoction.The evaluation of Li Shizhen (1518-1593 A.D.) to Radix Rehmanniae is: one hundred days of clothes are rosy cheeks, within 3 years, makes light of one's life by commiting suicide not old.The existing anastalsis of Radix Rehmanniae, has blood coagulation resisting function again.Antifungic action: the growth of Rehmannia glutinosa Libosch Water preserved material to multiple funguses such as trichophyton mentagrophytes, Gypsum Fibrosum sample microspore tinea bacterium, ulotrichy microspore tinea bacterium and Du's big belly microspore tinea bacterium difficult to understand has inhibitory action.The Radix Rehmanniae that affects of Endocrine has antagonism dexamethasone to the inhibitory action of Pituitary Adrenalcortical system, and can promote the synthesis of adrenocortical hormone. and there is clearing away heat and cooling blood effect and to join the army blood for warm febrile disease, high fever coma, xerostomia crimson tongue.As qingying decoction.

Fructus Rosae Laevigatae sour in the mouth, sweet, puckery, property is put down.There is controlling nocturnal emission with astringent drugs reducing urination, stopping metrorrhagia and leukorrhagia, effect of relieving diarrhea with astringents.Be usually used in emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses, chronic diarrhea chronic dysentery." book on Chinese herbal medicine is newly organized ": " Fructus Rosae Laevigatae, common people are competing to adopt with arresting seminal emission, and who knows that the sliding non-only puckery medicine of essence can stop also.The disease of seminal emission nocturnal emission, all urinate key and to close and orifice for discharging seminal fluid is opened, the medicine of dual-purpose diuretic is not to open urine key, and only uses the taste of arresting seminal emission with controlling nocturnal emission with astringent drugs door, therefore more puckery and more lose yet.So with Fructus Rosae Laevigatae, must dual-purpose Semen Euryales, Rhizoma Dioscoreae, Semen Nelumbinis, Semen Coicis and so on, single only seminal emission and essence is sliding anti-puckery, with puckery among profit, with mending within something lost, this medication secret, and real know medicine dark also.

Caulis Spatholobi chicken sedan-chair rattan bitter but slightly sweet taste, warm in nature, return liver, the heart, kidney channel; Red complexion enters blood, and matter profit row is loose; There is relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation; Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.The waist gonalgia, rheumatic arthralgia, the numb limbs and tense tendons for the treatment of caused by rheumatism, the compatibilities such as normal and Flos Carthami Semen Persicae, Radix Paeoniae Rubra, Pheretima, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae.Can be used for menoxenia, amenorrhea, dysmenorrhea, normal and Rhizoma Cyperi, Herba Leonuri are used together.

Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.Herba Leonuri, containing the material such as leonurine, Fumaric acid, has the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema.

Rhizoma Polygonati is used as medicine with rhizome.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat such as to be quenched one's thirst the disease.Very effective in cure for diabetes.Property sugariness put down, return spleen; Lung; Kidney channel is boosting qi and nourishing yin, spleen invigorating, lung moistening, the good medicine of kidney tonifying.Cure mainly deficiency of YIN chronic cough; Xeropulmonary cough; Insufficiency of the spleen weak; Lack of appetite xerostomia; Quench one's thirst; Deficiency of the kidney soreness of the waist and knees; Impotence and seminal emission; Tinnitus order is dark; Early whitening of beard and hair; Body void is won thin; Wind favus disease.Rhizoma Polygonati has blood pressure lowering, blood sugar lowering, blood fat reducing, atherosclerosis, and slow down aging and the effect such as antibacterial, polygonatum polysaccharide has Immunestimulatory effect.For lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and the chronic cough chronic cough etc. of YIN-deficiency of the lung and kidney.For weakness of the spleen and stomach.Both tonifying spleen-yin, again strengthening the spleen gas, obtain dizzy, soreness of the waist and knees for deficiency of kidney essence, early whitening of beard and hair and quenching one's thirst.The good medicine of nourishing of good lung moistening tonification.

The specific embodiment of the invention

Specific embodiment 1: during autumn, the Chinese herbaceous peony root of Radix Paeoniae Alba is all dug, excision bud head, cleans earth, and well-done with boiling water respectively by thickness is degree, and add the water yield to flood Chinese herbaceous peony root for degree, boiling time is determined according to Chinese herbaceous peony root thickness, to Chinese herbaceous peony root without the white heart as well; Let cool in water after pulling out and slightly soak, take out, scrape off crust, immediately dry in the sun.

The Radix Paeoniae Alba that dry in the sun is good is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.05 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.

By all the other crude drug Fructus Lyciis, Radix Salviae Miltiorrhizae, Radix Polygalae, Poria, Rhizoma Cyperi, Radix Trichosanthis, Radix Curcumae, the Radix Rehmanniae, Fructus Rosae Laevigatae, Herb Gynostemmae Pentaphylli, Rhizoma Imperatae, Herba Leonuri, Flos Gardeniae, Fructus Mori, Rhizoma Polygonati, Caulis Spatholobi, put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then put into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 80 DEG C 1.06 extractum, become component 2.

By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.36, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 2: during autumn, the Chinese herbaceous peony root of Radix Paeoniae Alba is all dug, excision bud head, cleans earth, and well-done with boiling water respectively by thickness is degree, and add the water yield to flood Chinese herbaceous peony root for degree, boiling time is determined according to Chinese herbaceous peony root thickness, to Chinese herbaceous peony root without the white heart as well; Let cool in water after pulling out and slightly soak, take out, scrape off crust, immediately dry in the sun.Radix Paeoniae Alba 5000g good for dry in the sun is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.By Fructus Lycii 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Polygalae 1500g, Poria 1500g, Rhizoma Cyperi 1500g, Radix Trichosanthis 1500g, Radix Curcumae 1500g, Radix Rehmanniae 1500g, Fructus Rosae Laevigatae 1500g, Herb Gynostemmae Pentaphylli 1500g, Rhizoma Imperatae 1500g, Herba Leonuri 1500g, Flos Gardeniae 1500g, Fructus Mori 1500g, Rhizoma Polygonati 1500g, Caulis Spatholobi 1500g, the medicine of all the other crude drug is put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then concentrating under reduced pressure tank is put into, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06 extractum, become component 2.By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.35, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 3: during autumn, the Chinese herbaceous peony root of Radix Paeoniae Alba is all dug, excision bud head, cleans earth, and well-done with boiling water respectively by thickness is degree, and add the water yield to flood Chinese herbaceous peony root for degree, boiling time is determined according to Chinese herbaceous peony root thickness, to Chinese herbaceous peony root without the white heart as well; Let cool in water after pulling out and slightly soak, take out, scrape off crust, immediately dry in the sun.Radix Paeoniae Alba 4000g good for dry in the sun is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.By Fructus Lycii 1200g, Radix Salviae Miltiorrhizae 1300g, Radix Polygalae 1200g, Poria 1300g, Rhizoma Cyperi 1200g, Radix Trichosanthis 1300g, Radix Curcumae 1200g, Radix Rehmanniae 1200g, Fructus Rosae Laevigatae 1300g, Herb Gynostemmae Pentaphylli 1300g, Rhizoma Imperatae 1300g, Herba Leonuri 1200g, Flos Gardeniae 1200g, Fructus Mori 1300g, Rhizoma Polygonati 1200g, Caulis Spatholobi 1200g, to soak in water 12 hours, then puts into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates are combined, by filtered through gauze, 50-60% ethanol is added in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, be condensed into pasty state by component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 4: during autumn, the Chinese herbaceous peony root of Radix Paeoniae Alba is all dug, excision bud head, cleans earth, and well-done with boiling water respectively by thickness is degree, and add the water yield to flood Chinese herbaceous peony root for degree, boiling time is determined according to Chinese herbaceous peony root thickness, to Chinese herbaceous peony root without the white heart as well; Let cool in water after pulling out and slightly soak, take out, scrape off crust, immediately dry in the sun.Radix Paeoniae Alba 3500g good for dry in the sun is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.By Fructus Lycii 1200g, Radix Salviae Miltiorrhizae 1300g, Radix Polygalae 1200g, Poria 1300g, Rhizoma Cyperi 1200g, Radix Trichosanthis 1300g, Radix Curcumae 1200g, Radix Rehmanniae 1200g, Fructus Rosae Laevigatae 1300g, Herb Gynostemmae Pentaphylli 1300g, Rhizoma Imperatae 1300g, Herba Leonuri 1200g, Flos Gardeniae 1200g, Fructus Mori 1300g, Rhizoma Polygonati 1200g, Caulis Spatholobi 1200g, after described crude drug being put into pulverizer pulverizing, puts into ethanol heating and refluxing extraction 2 times by particulate matter, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, above-mentioned two kinds of extracting solution are merged, as component 2; When to merge component 1 component 2 concentrating under reduced pressure relative density be 80 DEG C 1.36 filtrate, reclaim ethanol, call in dextrin or Mel, bottle after ultraviolet sterilization.

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of white mice, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicated powder is equivalent to 0.1g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicated powder dosage is > 42g/kg. day (every g medicated powder is equivalent to 0.1g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with matched group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safety range of the present invention is comparatively large, is a kind of safe and reliable health product.

Pharmacological experiment illustrates:

1 experiment material

1.1 medicines: the Radix Paeoniae Alba health tea (preparing by the method for embodiment 2) of nourishing blood to suppress the hyperactive liver of the present invention; Positive control drug: Piao Xue oral liquid, manufacturing enterprise: Pharmaceutical Factory No.6, Harbin Pharmaceutical Group, health care: the health care improving nutritional anemia.

1.2 animal Wistar rats, Kunming mouse, ♀ ♂ all uses.

2 impacts on ALT, ET, NO content in hepatic injury mice serum

2.1 groupings: get 105 kunming mices and be divided into 6 groups at random, often organize 15, A group is Normal group; B group is model control group; C group is positive controls; D1 group is low dose group of the present invention, and D2 group is dosage group in the present invention, and D3 group is high dose group of the present invention;

2.2 modeling methods: the method establishment immunological liver injury in mice model adopting bacillus calmette-guerin vaccine and lipopolysaccharide associating.After each treated animal adaptability feeds 3d, except Normal group, every mice 1 tail vein injection bacillus calmette-guerin vaccine 5 × 107 viable bacterias, 12d intravenous injection lipopolysaccharide 7.5 μ g/ Mus after injection of BCG, put to death after 16h and draw materials, Normal group injects normal saline 2 times all in the same way.

2.3 administrations and process: the first day of intravenous injection bacillus calmette-guerin vaccine plays beginning gastric infusion, 1 time/d.Normal group and model control group: normal saline gavage, gavage amount is with the medication capacity of medication therapy groups; Positive control medicine treatment group: Piao Xue oral liquid, 5.9g/kg dosed administration; Of the present invention group of low 3.9g/kg, middle 7.8g/kg, high 11.7g/kg dosed administration.Normal group is 16h after 12d injecting normal saline, and eyeball rear vein beard gets blood, and puts to death animal and get hepatic tissue censorship; All the other groups are 16h after intravenous injection lipopolysaccharide, and eyeball rear vein beard gets blood, and puts to death animal and get hepatic tissue censorship.

2.4 observation index and detection method: 1. detect glutamate pyruvate transaminase (ALT): adopt chemical colorimetry to measure.2. endogenous nitric oxide (NO) measures: adopt radioimmunology, take 0.5g liver and make 10% liver tissue homogenate, under 4 DEG C of conditions, 3000 turns/min, centrifugal 10min, gets supernatant.3. Endothelin (ET) detects: adopt radiation to exempt from method and directly measure blood plasma ET concentration.

Serum ALT respectively organized by table 1, the situation of change of ET, NO compares

* compare with model group, * P < 0.05, * * P < 0.01; △ compares with positive controls, △ P < 0.05.

3, to the protective effect of chronic hepatic injury

Rat skin lower injection 10%5ml/kg carbon tetrachloride oil solution, 2 times weekly, injection 3 months, causes carbon tetrachloride chronic hepatic injury animal model continuously, observes the protective effect of medicine of the present invention to damage liver.

Normal group and model control group: normal saline gavage, gavage amount is with the medication capacity of medication therapy groups; Positive control medicine treatment group: Piao Xue oral liquid, 2.7g/kg dosed administration; The present invention, 2.7g/kg dosed administration.Normal group is 16h after 12d injecting normal saline, and eyeball rear vein beard gets blood, and puts to death animal and get hepatic tissue censorship; All the other groups are 16h after intravenous injection lipopolysaccharide, and eyeball rear vein beard gets blood, and puts to death animal and get hepatic tissue censorship.

Table 2 medicine of the present invention is to the protective effect (X ± SD) of chronic hepatic injury rat

As can be seen from the above results, detecting qualified medicine of the present invention has significance to improve to ALT, ET, NO content in hepatic injury mice serum, and has obvious protective effect to chronic hepatic injury, and comparing with positive control medicine has significant difference.

Clinical trial:

One, experimental subject: adopt Chinese medicine health-care oral liquid of the present invention to test in 60 routine women altogether, the oldest person 45 years old, age reckling 21 years old.Major part sufferer is white collar, and readme mostly has menoxenia, and pox is played in face, and mottle is serious, blurred vision, nyctalopia; Insomnia forgetfulness, deficiency of the yin of the liver, two dryness and uneasy feeling of the eye, visual deterioration; Flaming up of liver-fire, conjunctival congestion and swelling pain; Frequent eyes are dry astringent, stay up late, dinner party of drinking; And dim complexion, matched group 60 people, the oldest 48 years old, minimum 21 years old.Disease is identical or similar, adopts commercially available WUJI BAIFENG WAN to nurse one's health.

Therapeutic Method:

Usage and dosage: treatment group adopts Chinese medicine health-care oral liquid of the present invention.Fang Yong: Radix Paeoniae Alba 25g, Fructus Lycii 11g, Radix Salviae Miltiorrhizae 12g, Radix Polygalae 13g, Poria 12g, Rhizoma Cyperi 11g, Radix Trichosanthis 11g, Radix Curcumae 12g, Radix Rehmanniae 11g, Fructus Rosae Laevigatae 12g, Herb Gynostemmae Pentaphylli 12g, Rhizoma Imperatae 12g, Herba Leonuri 13g, Flos Gardeniae 12g, Fructus Mori 11g, Rhizoma Polygonati 11g, Caulis Spatholobi 12g, its usage and consumption as follows: each one bottle of every day 3 times.The course for the treatment of: be limited for one month.Matched group is WUJI BAIFENG WAN daily, within one month, is limited.

The standard of curative effect evaluation

Cure: above symptom and sign improves completely, and patient is without any bad sensation, happy, in high spirits, the eumenorrhea, sleeps.Effective: sign is significantly improved, patient is substantially without bad sensation, happy, and spirit very well.Effective: sign obviously changes, random thoughts are slightly uncomfortable, but can accept, and mood is better, and energy is more abundant.Invalid: sign is without any change, and symptom, as front, feels depressed, and lethargy is depressed.Dim complexion, eyes or dry astringent.

The results are shown in Table 1 liang of group comparitive study (%)

Treatment group successful is higher than matched group.Show that oral liquid replaces Chinese medicine, drink as daily, can mouthfeel be improved, also allow people not produce and detest psychology, Chinese medicine odor is no longer repelled.Woman's health preserving allows and oneself becomes more healthy and beautiful, and many woman understand to be needed to maintain oneself by various mode after busy, but when taking action, we but usually easily go on wrong path.Woman wants health preserving, first thing be exactly from nourish blood and enrich blood s, color has been got well, women health just have talk.Woman maintain the first step be exactly with blood for because the menstruation of women, tire are pregnant, the physiological characteristics such as delivery and feed infant and suckling all easily consumes blood, so female organism is relatively easily in the state of blood system deficiency.Say as " a Ling Shu Miraculous Pivot or Divine Axis five flavours and five notes of traditional Chinese music section ": " life of women, has a surplus in gas, be not enough to blood, with its number collapse due to massive hemorrhage also." so, first female health preserving should be paid attention to maintaining QI and blood.Hemapodium just can make to have rosy cheeks beautiful, menses normal, spirit is vigorous.Nourish blood if be bad at, just easily occur that shallow complexion is simple and unadorned, lip and nail are pale, dizziness and blurred vision, fatigue and weakness, dried and withered hairs limb are numb, few through blood volume, delay in menstrual period, light red tongue thready pulse etc.During severe anemia, also easily occur wrinkle early raw, grey hair early white, climacteric the premature exhaustion such as in advance.

In view of the traditional Chinese medical science has the characteristic of dialectical treatmert, the advantage that Chinese medicine toxic side effect is little, Chinese medicine health-care treatment causes extensive concern.The Radix Paeoniae Alba is cold, bitter in the mouth acid, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receive the effect such as antiperspirant, can treat the diseases such as fever due to yin deficiency, menoxenia, dysentery stomachache, can also invigorating qi and benefiting blood, whitening and speckle dispelling.The present invention organically combines theoretical for modern nutriology with Chinese Traditional Medicine health care theory, can scavenging free radicals, promote hepatocellular regeneration, enrich blood easing the affected liver, suppressing the hyperactive liver pain relieving, yin fluid astringing receives the effect such as antiperspirant, the diseases such as fever due to yin deficiency, menoxenia, dysentery stomachache can be treated, can also invigorating qi and benefiting blood, whitening and speckle dispelling.

Claims

1. the Radix Paeoniae Alba health care oral liquid of a nourishing blood to suppress the hyperactive liver, it is characterized in that, described health care oral liquid comprises the crude drug of following parts by weight: the Radix Paeoniae Alba 10 ~ 50 parts, Fructus Lycii 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Rhizoma Cyperi 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Fructus Rosae Laevigatae 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Flos Gardeniae 10 ~ 20 parts, 10 ~ 20 parts, Fructus Mori, Rhizoma Polygonati 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts.

2. the Radix Paeoniae Alba health care oral liquid of nourishing blood to suppress the hyperactive liver according to claim 1, it is characterized in that, the parts by weight of described health care oral liquid crude drug are: the Radix Paeoniae Alba 10 ~ 30 parts, Fructus Lycii 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Radix Polygalae 10 ~ 15 parts, 10 ~ 15 parts, Poria, Rhizoma Cyperi 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, Radix Curcumae 10 ~ 15 parts, 10 ~ 15 parts, the Radix Rehmanniae, Fructus Rosae Laevigatae 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Flos Gardeniae 10 ~ 20 parts, 10 ~ 20 parts, Fructus Mori, Rhizoma Polygonati 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts.

3. the Radix Paeoniae Alba health care oral liquid of nourishing blood to suppress the hyperactive liver according to claim 1, it is characterized in that, the parts by weight of described health care oral liquid crude drug are: the Radix Paeoniae Alba 10 ~ 40 parts, Fructus Lycii 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Rhizoma Cyperi 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Fructus Rosae Laevigatae 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, Rhizoma Imperatae 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Flos Gardeniae 10 ~ 15 parts, 10 ~ 15 parts, Fructus Mori, Rhizoma Polygonati 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts.

4. the preparation method of the Radix Paeoniae Alba health care oral liquid of nourishing blood to suppress the hyperactive liver according to any one of claims 1 to 3, it is characterized in that, the preparation process of described health care oral liquid comprises:

A. the preparation of the Radix Paeoniae Alba, as component 1;

5. the preparation method of the Radix Paeoniae Alba health care oral liquid of nourishing blood to suppress the hyperactive liver according to claim 4, it is characterized in that, in described step a, all dug by the Chinese herbaceous peony root of Radix Paeoniae Alba during autumn, excision bud head, cleans earth, well-done with boiling water respectively by thickness is degree, add the water yield to flood Chinese herbaceous peony root for degree, boiling time is determined according to Chinese herbaceous peony root thickness, to Chinese herbaceous peony root without the white heart as well; Let cool in water after pulling out and slightly soak, take out, scrape off crust, immediately dry in the sun.

6. the preparation method of the Radix Paeoniae Alba health care oral liquid of nourishing blood to suppress the hyperactive liver according to claim 4, is characterized in that, in described step a, comprise further, the Radix Paeoniae Alba that dry in the sun is good is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.

7. the preparation method of the Radix Paeoniae Alba health care oral liquid of nourishing blood to suppress the hyperactive liver according to claim 4, is characterized in that, in described step b, the medicine of all the other crude drug is put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, then puts into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 80 DEG C 1.06 extractum, become component 2.

8. the preparation method of the Radix Paeoniae Alba health care oral liquid of nourishing blood to suppress the hyperactive liver according to claim 4, is characterized in that, in described step c, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.36, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.

9. the preparation method of the Radix Paeoniae Alba health care oral liquid of nourishing blood to suppress the hyperactive liver according to any one of claims 1 to 3, it is characterized in that, its preparation process can also be:

A. the preparation of the Radix Paeoniae Alba, as component 1;

B. all the other crude drug described soaked, extract 3 times as component 2;

10. the preparation method of the Radix Paeoniae Alba health care oral liquid of nourishing blood to suppress the hyperactive liver according to claim 9, is characterized in that, in described step b, to be soaked by all the other crude drug in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge lixiviating solution, being condensed into pasty state becomes component 2.