CN105107010A - Preparation method of oxidized cellulose external applying material with anti-microbial and detumescence effect - Google Patents
Preparation method of oxidized cellulose external applying material with anti-microbial and detumescence effect Download PDFInfo
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- CN105107010A CN105107010A CN201510611457.0A CN201510611457A CN105107010A CN 105107010 A CN105107010 A CN 105107010A CN 201510611457 A CN201510611457 A CN 201510611457A CN 105107010 A CN105107010 A CN 105107010A
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Abstract
The invention discloses a preparation method of an oxidized cellulose external applying material with an anti-microbial and detumescence effect. The preparation method comprises the following steps: firstly, dissolving hydroxypropyl methyl cellulose (HPMC) in deionized water, adding sorbitol, polyethylene glycol and water soluble chitosan, increasing the temperature and stirring to obtain a mixture I; heating lauroyl peroxide and 2-ethyl-4-methylimidazole for reaction under the inert gas shielding condition, cooling to room temperature, adding glutaraldehyde, heating for reaction under a negative pressure condition to obtain a mixture II; adding a safflower extract, a radix notoginseng extract and a honeysuckle extract into the mixture I, uniformly mixing, adding the mixture II, increasing the temperature, stirring, and leaving the mixture to stand for reaction to obtain the oxidized cellulose external applying material with the anti-microbial and detumescence effect. According to the preparation method of the oxidized cellulose external applying material with the anti-microbial and detumescence effect, provided by the invention, the external applying material prepared by adopting the preparation method has an excellent bleeding-arresting and detumescence performance, has obvious advantages when being compared with the conventional materials, and further has a good application prospect.
Description
Technical field
The invention belongs to medical material field, be specifically related to a kind of preparation method of the outer compress material of oxidized cellulose of antibacterial detumescence.
Background technology
Along with growing interest and the attention of global environmental pollution and shortage of resources problem, there is biodegradability, the material of environment compatibility becomes the focus that countries in the world are competitively developed.Cellulose is inexhaustible, the nexhaustible organic resource of renewable natural polymer the abundantest on the earth and occurring in nature, and cellulosic material itself is nontoxic, water-resistance is strong, meet biodegradability, the requirement of Study on Environment Compatible Materials, thus cellulose becomes as the use of host material and the exploitation of cellulose derivative the focus that Now Domestic studies outward.Cellulose derivative, as carboxymethyl cellulose, hydroxypropyl cellulose etc., makes its range of application in the industry very extensive because of this kind of high molecular biocompatibility, biodegradability and avirulence.Chemical modification obtains this kind of high molecular effective ways with property.Oxidation reaction, especially selective oxidation reaction, can some or certain several hydroxyl on the glucose residue of optionally oxidized cellulose macromole basic ring, and introduce new functional group at ad-hoc location, as carboxyl, aldehyde radical or carbonyl, this kind of cellulose oxidation thing can make cellulose have new purposes because of its unique texture.Oxidized cellulose is widely applied as hemorrhage at medical field at present, can play good anastalsis.Actually rare for the medical material based on oxidized cellulose at present, dimension needs exploitation to have the medical material of several functions, expands its range of application further.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art and the preparation method of the outer compress material of a kind of oxidized cellulose of antibacterial detumescence is provided, improving preparation efficiency, prepare the outer compress material of function admirable.
Technical scheme of the present invention is as follows:
A preparation method for the outer compress material of oxidized cellulose of antibacterial detumescence, comprises the following steps:
Step one, the hydroxypropyl emthylcellulose 3-8 part with parts by weight be dissolved in 80-100 part deionized water, then add sorbitol 2-5 part, Polyethylene Glycol 1-3 part, water-soluble chitosan 2-6 part, is warming up to 50-60 DEG C, stirs 20-30 minute, obtains mixture one;
Step 2, by with lauroyl peroxide 0.5-1 part of parts by weight, 2-ethyl-4-methylimidazole 1-2 part is heated to 50-60 DEG C under the condition of inert gas shielding, reaction 30-50 minute, be down to room temperature, add glutaraldehyde 1-3 part, and then be heated to 40-50 DEG C under condition of negative pressure, stirring reaction 15-20 minute, obtains mixture two;
Step 3, by with Flos Carthami extract 1-4 part of parts by weight, Radix Notoginseng extract 1-3 part, Flos Lonicerae extract 2-4 part joins in mixture one, mix homogeneously, then adds mixture two, is warming up to 30-40 DEG C, stir after 10-20 minute and leave standstill, obtain the outer compress material of oxidized cellulose of antibacterial detumescence.
The preparation method of the outer compress material of oxidized cellulose of described antibacterial detumescence, in step one, Polyethylene Glycol is Macrogol 600 or polyethylene glycol-800.
The preparation method of the outer compress material of oxidized cellulose of described antibacterial detumescence, the noble gas in step 2 is nitrogen or argon.
The preparation method of the outer compress material of oxidized cellulose of described antibacterial detumescence, in step 2, the pressure of condition of negative pressure is 0.02-0.05MPa.
The preparation method of the outer compress material of oxidized cellulose of described antibacterial detumescence, in step 3, mixing speed is 60-80 rev/min.
The preparation method of the outer compress material of oxidized cellulose of described antibacterial detumescence, the time left standstill in step 3 is 100-150 minute.
The outer compress material that preparation method provided by the invention prepares has excellent hemostasis and detumescence performance, has obvious advantage, have a good application prospect compared with traditional material.
Detailed description of the invention
Embodiment 1
A preparation method for the outer compress material of oxidized cellulose of antibacterial detumescence, comprises the following steps:
Step one, be dissolved in 80 parts of deionized waters by the hydroxypropyl emthylcellulose 3 parts with parts by weight, then add sorbitol 2 parts, Macrogol 600 1 part, water-soluble chitosan 2 parts, is warming up to 50 DEG C, stirs 20 minutes, obtains mixture one;
Step 2, by with the lauroyl peroxide 0.5 part of parts by weight, 2-ethyl-4-methylimidazole 1 part is heated to 50 DEG C under the condition of nitrogen protection, react 30 minutes, be down to room temperature, add glutaraldehyde 1 part, and then at pressure be 0.02MPa condition of negative pressure under be heated to 40 DEG C, stirring reaction 15 minutes, obtains mixture two;
Step 3, by with the Flos Carthami extract 1 part of parts by weight, Radix Notoginseng extract 1 part, Flos Lonicerae extract 2 parts joins in mixture one, mix homogeneously, then adds mixture two, is warming up to 30 DEG C, leave standstill 100 minutes after stirring 10 minutes with 60 revs/min, obtain the outer compress material of oxidized cellulose of antibacterial detumescence.
Embodiment 2
A preparation method for the outer compress material of oxidized cellulose of antibacterial detumescence, comprises the following steps:
Step one, be dissolved in 85 parts of deionized waters by the hydroxypropyl emthylcellulose 4 parts with parts by weight, then add sorbitol 3 parts, polyethylene glycol-800 2 parts, water-soluble chitosan 3 parts, is warming up to 52 DEG C, stirs 24 minutes, obtains mixture one;
Step 2, by with the lauroyl peroxide 0.6 part of parts by weight, 2-ethyl-4-methylimidazole 1 part is heated to 55 DEG C under the condition of argon shield, react 38 minutes, be down to room temperature, add glutaraldehyde 2 parts, and then at pressure be 0.03MPa condition of negative pressure under be heated to 44 DEG C, stirring reaction 16 minutes, obtains mixture two;
Step 3, by with the Flos Carthami extract 2 parts of parts by weight, Radix Notoginseng extract 2 parts, Flos Lonicerae extract 3 parts joins in mixture one, mix homogeneously, then adds mixture two, is warming up to 35 DEG C, leave standstill 120 minutes after stirring 15 minutes with 70 revs/min, obtain the outer compress material of oxidized cellulose of antibacterial detumescence.
Embodiment 3
A preparation method for the outer compress material of oxidized cellulose of antibacterial detumescence, comprises the following steps:
Step one, be dissolved in 90 parts of deionized waters by the hydroxypropyl emthylcellulose 6 parts with parts by weight, then add sorbitol 4 parts, Macrogol 600 2 parts, water-soluble chitosan 5 parts, is warming up to 58 DEG C, stirs 25 minutes, obtains mixture one;
Step 2, by with the lauroyl peroxide 0.8 part of parts by weight, 2-ethyl-4-methylimidazole 2 parts is heated to 56 DEG C under the condition of nitrogen protection, react 45 minutes, be down to room temperature, add glutaraldehyde 3 parts, and then at pressure be 0.04MPa condition of negative pressure under be heated to 48 DEG C, stirring reaction 17 minutes, obtains mixture two;
Step 3, by with the Flos Carthami extract 3 parts of parts by weight, Radix Notoginseng extract 2 parts, Flos Lonicerae extract 3 parts joins in mixture one, mix homogeneously, then adds mixture two, is warming up to 38 DEG C, leave standstill 140 minutes after stirring 16 minutes with 75 revs/min, obtain the outer compress material of oxidized cellulose of antibacterial detumescence.
Embodiment 4
A preparation method for the outer compress material of oxidized cellulose of antibacterial detumescence, comprises the following steps:
Step one, be dissolved in 100 parts of deionized waters by the hydroxypropyl emthylcellulose 8 parts with parts by weight, then add sorbitol 5 parts, polyethylene glycol-800 3 parts, water-soluble chitosan 6 parts, is warming up to 60 DEG C, stirs 30 minutes, obtains mixture one;
Step 2, by with the lauroyl peroxide 1 part of parts by weight, 2-ethyl-4-methylimidazole 2 parts is heated to 60 DEG C under the condition of nitrogen protection, react 50 minutes, be down to room temperature, add glutaraldehyde 3 parts, and then at pressure be 0.05MPa condition of negative pressure under be heated to 50 DEG C, stirring reaction 20 minutes, obtains mixture two;
Step 3, by with the Flos Carthami extract 4 parts of parts by weight, Radix Notoginseng extract 3 parts, Flos Lonicerae extract 4 parts joins in mixture one, mix homogeneously, then adds mixture two, is warming up to 40 DEG C, leave standstill 150 minutes after stirring 20 minutes with 80 revs/min, obtain the outer compress material of oxidized cellulose of antibacterial detumescence.
In preparation method provided by the invention, the mixture two prepared by step 2 is multiple crosslinking agent, other components effectively can be cross-linked by this cross-linking agent, composite can be cross-linked to form in the shorter time, found by the research repeatedly in process of the test, this cross-linking agent can make material form similar cellular many hollow structures in crosslinked process, make the material curative effect factor inner in the process used better and contact skin and then play function, the action effect of material can be improve.
The oxidized cellulose external application material properties test of the antibacterial detumescence that above embodiment is prepared, specific as follows:
1. the haemostatic effect of mice docking experiment
Employing Kun Ming mice is laboratory animal, 100, body weight 30-35g.Experiment point 4 groups: blank group, experimental group A, experimental group B, experimental group C, often organize 25, be fixed on by mice in mouse fixing device, with alcohol swab sterilization mousetail end, cuts and cut off at Mouse Tail-tip 1cm place, have blood flow to go out with sharp shears.Each experimental group carries out lower column processing: (1) blank group otch exposes; (2) the chitosan wound surface bleeding-stopping dressing prepared in the above embodiment that docking place closely sticks 1cm × 1cm of experimental group A, B, C.Observe mice docking place bleeding in experiment, every 10s filter paper sucks wound oozing of blood, until stopped bleeding, and record bleeding stopping period.Experiment condition and result as shown in the table:
As can be seen from the above results, the medical dressing that preparation method of the present invention prepares can quick-acting haemostatic powder, and relative to blank group, the time needed for hemostasis greatly shortens, and application process is simple.
2. antibacterial detumescence test: in March, 2015-May is in shallow table abscess patient 100 example of certain hospital admission, age 18-60 year, stochastic averagina is distributed into 4 groups, wherein two groups use traditional wound repair antiseptic dressing, another two groups of outer compress materials using the present invention to prepare, and observe swelling time, do not infect for recovery from illness to subside a swelling completely simultaneously, observe the recovery from illness quantity of different time, two groups of recovery from illness quantity summations contrasted, result is as following table:
As can be seen from upper result, the outer compress material that the embodiment of the present invention prepares patient's cure rate when use 5 days reaches more than 96%, and traditional dressing 5 angel cure rate is 76%, and recovery from illness speed is obviously accelerated.
Comprehensively the above can be found out, preparation method provided by the invention improves preparation efficiency, and the outer compress material simultaneously prepared has excellent hemostasis and antibacterial detumescence performance.
Claims (6)
1. a preparation method for the outer compress material of the oxidized cellulose of antibacterial detumescence, is characterized in that, comprise the following steps:
Step one, the hydroxypropyl emthylcellulose 3-8 part with parts by weight be dissolved in 80-100 part deionized water, then add sorbitol 2-5 part, Polyethylene Glycol 1-3 part, water-soluble chitosan 2-6 part, is warming up to 50-60 DEG C, stirs 20-30 minute, obtains mixture one;
Step 2, by with lauroyl peroxide 0.5-1 part of parts by weight, 2-ethyl-4-methylimidazole 1-2 part is heated to 50-60 DEG C under the condition of inert gas shielding, reaction 30-50 minute, be down to room temperature, add glutaraldehyde 1-3 part, and then be heated to 40-50 DEG C under condition of negative pressure, stirring reaction 15-20 minute, obtains mixture two;
Step 3, by with Flos Carthami extract 1-4 part of parts by weight, Radix Notoginseng extract 1-3 part, Flos Lonicerae extract 2-4 part joins in mixture one, mix homogeneously, then adds mixture two, is warming up to 30-40 DEG C, stir after 10-20 minute and leave standstill, obtain the outer compress material of oxidized cellulose of antibacterial detumescence.
2. the preparation method of the outer compress material of the oxidized cellulose of antibacterial detumescence according to claim 1, it is characterized in that, in step one, Polyethylene Glycol is Macrogol 600 or polyethylene glycol-800.
3. the preparation method of the outer compress material of the oxidized cellulose of antibacterial detumescence according to claim 1, it is characterized in that, the noble gas in step 2 is nitrogen or argon.
4. the preparation method of the outer compress material of the oxidized cellulose of antibacterial detumescence according to claim 1, it is characterized in that, in step 2, the pressure of condition of negative pressure is 0.02-0.05MPa.
5. the preparation method of the outer compress material of the oxidized cellulose of antibacterial detumescence according to claim 1, it is characterized in that, in step 3, mixing speed is 60-80 rev/min.
6. the preparation method of the outer compress material of the oxidized cellulose of antibacterial detumescence according to claim 1, it is characterized in that, the time left standstill in step 3 is 100-150 minute.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1944495A (en) * | 2006-09-29 | 2007-04-11 | 北京大学 | Water gel containing natural high molecule and its radiation preparing method |
| US20110110898A1 (en) * | 1999-11-05 | 2011-05-12 | Don Kleinsek | Bioactive removal of hypertrophic scars |
| CN103877606A (en) * | 2014-01-23 | 2014-06-25 | 华侨大学 | Absorbable bleeding-stopping compound sponge and preparation method thereof |
| CN104524623A (en) * | 2014-12-17 | 2015-04-22 | 安徽省健源医疗器械设备有限公司 | Cactus hemostatic gauze and preparation method thereof |
| CN104562438A (en) * | 2013-10-17 | 2015-04-29 | 中国科学院理化技术研究所 | Gelatin-based micro-nanofiber membrane material, preparation method and utilization thereof |
-
2015
- 2015-09-23 CN CN201510611457.0A patent/CN105107010A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110110898A1 (en) * | 1999-11-05 | 2011-05-12 | Don Kleinsek | Bioactive removal of hypertrophic scars |
| CN1944495A (en) * | 2006-09-29 | 2007-04-11 | 北京大学 | Water gel containing natural high molecule and its radiation preparing method |
| CN104562438A (en) * | 2013-10-17 | 2015-04-29 | 中国科学院理化技术研究所 | Gelatin-based micro-nanofiber membrane material, preparation method and utilization thereof |
| CN103877606A (en) * | 2014-01-23 | 2014-06-25 | 华侨大学 | Absorbable bleeding-stopping compound sponge and preparation method thereof |
| CN104524623A (en) * | 2014-12-17 | 2015-04-22 | 安徽省健源医疗器械设备有限公司 | Cactus hemostatic gauze and preparation method thereof |
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Application publication date: 20151202 |