CN105044924A - Method for preparing contact lenses by means of naturally-extracted chitin - Google Patents
Method for preparing contact lenses by means of naturally-extracted chitin Download PDFInfo
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- CN105044924A CN105044924A CN201510576184.0A CN201510576184A CN105044924A CN 105044924 A CN105044924 A CN 105044924A CN 201510576184 A CN201510576184 A CN 201510576184A CN 105044924 A CN105044924 A CN 105044924A
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Abstract
The invention relates to a method for preparing contact lenses by means of naturally-extracted chitin, and belongs to the technical field of contact lenses. In order to solve the problems that in the use process of existing contact lenses, the lenses are dry, poor in water retention capacity and high in hardness, and it cannot be guaranteed that the cornea is not injured, the method for preparing the contact lenses free of irritant injuries to the cornea by means of the naturally-extracted chitin is provided, natural chitin is used for preparing the contact lenses, the contact lenses are effectively matched with the cornea of a human body, and no stimulation is caused to the human body. The contact lenses are excellent in water retention capacity and can be worn by more than 8 hours, and the eyes cannot feel dry.
Description
Technical field
The present invention relates to a kind of method that natural chitin extraction prepares contact lenses, belong to contact lens technique field.
Background technology
Contact lenses (contactlens), are also contact lens, are that one is worn on cornea, in order to correct defects of vision or to protect the eyeglass of eyes.According to the soft or hard of material, it comprises rigid, semi-hard, soft three kinds, contact lenses are not only from bringing very large improvement to convenience aspect in appearance the ametropia patients such as myopia, long sight, astigmatism, and the visual field is broad, to look thing true to nature, this external control adolescent myopia, astigmatism develop, and treat the aspects such as special illness in eye and have also played special effect.Today that introduction is being followed the fashion, all kinds of contact lenses emerge in an endless stream, and the contact lenses of frivolous fashion occupy windward, thus instead of the position of frame eyeglasses.Frivolous contact lenses are that one is worn on cornea, in order to correct defects of vision or to protect the eyeglass of eyes.The arrival of contact lenses gives us from appearance with ready-to-use type, has all brought and has greatly taken on a new look.
But permanent contact lens wear, easily produce visual fatigue, even cause xerophthalmia.Cause that eye acid is itched, foreign body sensation, many gums, sensation of dryness, eyes burn and blurred vision, protein, lipid, collagen etc. in contact lenses absorption tear, make it to be deposited on lens surface, grow germ, therefore the reaction of corneal edema, cornea rebirth blood vessel and allergic reaction etc. play particularly contact lenses wearing and tearing cornea, may cause the serious consequence of exfoliation of corneal epithelium or perforation.Part contact lens concavity and cornea convexity are not inconsistent, and irregular wear cornea, causes ulcer of the cornea, cause irreversible visual impairment, even if can leave hickie on cornea after treatment yet.So need a kind of laminating human body, the non-stimulated injury of corneal and the contact lenses of moisture water retention property excellence are necessary.
Summary of the invention
The technical matters that the present invention mainly solves: in current contact lenses use procedure glasses dry and astringent water retention property difference and the higher problem that cannot ensure not injure cornea of hardness provide a kind of by natural chitin extraction prepare corneal nonirritant injury contact lenses method, effectively alleviate eyes in contact lens dry and astringent, the problem of shouting pain.
In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is:
(1) 10 ~ 15g peptone, 10 ~ 15g beef extract, 8 ~ 10g dusty yeast, 1 ~ 2g potassium phosphate, 2 ~ 3g dibasic ammonium citrate, 2 ~ 5g sodium acetate, 15 ~ 20g glucose sugar, 0.1 ~ 0.5g polyoxyethylene sorbitan monooleate, 0.2 ~ 0.5g magnesium sulfate is chosen, above-mentioned material deionized water is settled to 1000mL, is prepared into fluid nutrient medium;
(2) lactobacillus inoculum is carried out activation culture in fresh sterilized non-fat Ruzhong, ensure that its temperature is 36 ~ 37 DEG C, after being cultured to Coagulation of milk, the lactic acid bacteria of cultivation is undertaken being inoculated in fluid nutrient medium by 1% of fluid nutrient medium, carry out cultivation 10 ~ 12h at temperature is 36 ~ 37 DEG C after, refrigerate for subsequent use;
(3) fresh shrimp shell cleaned and remove after impurity, dry 3 ~ 5h at being placed on 100 ~ 105 DEG C, after its drying, after adopting airslide disintegrating mill to be pulverized, get its pulverizing shrimp shell 200g and be placed in 1000mL Erlenmeyer flask, 30g glucose sugar and fermentation liquor of 50mL are added in Erlenmeyer flask to it simultaneously, be uniformly mixed under 300 ~ 400r/min rotating speed;
(4) after it mixes, flask is placed in air constant-temperature table, arranging rotating speed is 300r/min, carry out fermentation process 15 ~ 20h, after it has fermented, it is filtered, then be 6.5 ~ 7.0 by deionized water washing filter residue to pH, and at 100 ~ 105 DEG C, dry 3 ~ 4h, i.e. separable solid-state chitin;
(5) count by weight, choose the solid-state chitin of 20 ~ 59.9 parts of preparations, 40 ~ 50 parts of acryl resins, the azoisobutyronitrile of 0.01 ~ 10 part, benzoyl peroxides of 0.01 ~ 25 part, at 80 ~ 130 DEG C, form chitin bottom blended polymer after stirring reaction 20 ~ 24h, then form transparent cambered surface bottom through turning;
(6) count by weight, be 2 ~ 5 μm of natural earth pigments by the particle diameter of the acryl resin of 50 ~ 80 parts, the azoisobutyronitrile of 0.01 ~ 10 part, the benzoyl peroxide of 0.01 ~ 30 part and 1 ~ 40 part, 10 ~ 60min is polymerized at 20 ~ 50 DEG C, obtain the polymer coating that viscosity is 8000 ~ 200000mPas, again the cambered surface bottom that step (5) is obtained is placed in die, the pattern being printed on dope layer is transferred to the iris district of bottom, intermediate primer layer;
(7) add die after being polymerized by the material of bottom same composition, with the speed rotating cavity die of 400 ~ 1600r/min, and to its irradiation polymerization 2 ~ 20min, the contact lenses that can obtain a kind of natural chitin extraction have been prepared on top layer the most at last.
Described irradiation polymerization device radiation dose rate is 6kGy/h, and irradiation dose is 300kGy.
Application process of the present invention is: worn by the chitin contact lenses of preparation, and A nearsighted person is wearing without any tingling sensation in process, and wears 8 ~ 10h and also occur without dry and astringent situation.
The invention has the beneficial effects as follows:
(1) adopt natural chitin to prepare contact lenses, effectively match with human cornea, non-stimulated to human body;
(2) contact lenses water retention property is excellent, can wear more than 8h eyes and not occur dry and astringent situation.
embodiment:
Choose 10 ~ 15g peptone, 10 ~ 15g beef extract, 8 ~ 10g dusty yeast, 1 ~ 2g potassium phosphate, 2 ~ 3g dibasic ammonium citrate, 2 ~ 5g sodium acetate, 15 ~ 20g glucose sugar, 0.1 ~ 0.5g polyoxyethylene sorbitan monooleate, 0.2 ~ 0.5g magnesium sulfate, above-mentioned material deionized water is settled to 1000mL, is prepared into fluid nutrient medium; Lactobacillus inoculum is carried out activation culture in fresh sterilized non-fat Ruzhong, ensure that its temperature is 36 ~ 37 DEG C, after being cultured to Coagulation of milk, the lactic acid bacteria of cultivation is undertaken being inoculated in fluid nutrient medium by 1% of fluid nutrient medium, carry out cultivation 10 ~ 12h at temperature is 36 ~ 37 DEG C after, refrigerate for subsequent use; Fresh shrimp shell is cleaned and removes after impurity, dry 3 ~ 5h at being placed on 100 ~ 105 DEG C, after its drying, after adopting airslide disintegrating mill to be pulverized, get its pulverizing shrimp shell 200g and be placed in 1000mL Erlenmeyer flask, 30g glucose sugar and fermentation liquor of 50mL are added in Erlenmeyer flask to it simultaneously, be uniformly mixed under 300 ~ 400r/min rotating speed; After it mixes, flask is placed in air constant-temperature table, arranging rotating speed is 300r/min, carry out fermentation process 15 ~ 20h, after it has fermented, it is filtered, then be 6.5 ~ 7.0 by deionized water washing filter residue to pH, and at 100 ~ 105 DEG C, dry 3 ~ 4h, i.e. separable solid-state chitin; Count by weight, choose the solid-state chitin of 20 ~ 59.9 parts of preparations, 40 ~ 50 parts of acryl resins, the azoisobutyronitrile of 0.01 ~ 10 part, benzoyl peroxides of 0.01 ~ 25 part, at 80 ~ 130 DEG C, form chitin bottom blended polymer after stirring reaction 20 ~ 24h, then form transparent cambered surface bottom through turning; Count by weight, be 2 ~ 5 μm of natural earth pigments by the particle diameter of the acryl resin of 50 ~ 80 parts, the azoisobutyronitrile of 0.01 ~ 10 part, the benzoyl peroxide of 0.01 ~ 30 part and 1 ~ 40 part, 10 ~ 60min is polymerized at 20 ~ 50 DEG C, obtain the polymer coating that viscosity is 8000 ~ 200000mPas, again obtained cambered surface bottom is placed in die, the pattern being printed on dope layer is transferred to the iris district of bottom, intermediate primer layer; Add die after being polymerized by the material of bottom same composition, with the speed rotating cavity die of 400 ~ 1600r/min, and to its irradiation polymerization 2 ~ 20min, the contact lenses that can obtain a kind of natural chitin extraction have been prepared on top layer the most at last; Described irradiation polymerization device radiation dose rate is 6kGy/h, and irradiation dose is 300kGy.The present invention adopts natural chitin to prepare contact lenses, effectively matches with human cornea, non-stimulated to human body; Contact lenses water retention property is excellent, can wear more than 8h eyes and not occur dry and astringent situation.
Example 1
Choose 10g peptone, 10g beef extract, 8g dusty yeast, 1g potassium phosphate, 2g dibasic ammonium citrate, 2g sodium acetate, 15g glucose sugar, 0.1g polyoxyethylene sorbitan monooleate, 0.2g magnesium sulfate, above-mentioned material deionized water is settled to 1000mL, is prepared into fluid nutrient medium; Lactobacillus inoculum is carried out activation culture in fresh sterilized non-fat Ruzhong, ensure that its temperature is 36 DEG C, after being cultured to Coagulation of milk, the lactic acid bacteria of cultivation is undertaken being inoculated in fluid nutrient medium by 1% of fluid nutrient medium, carry out cultivation 10h at temperature is 36 DEG C after, refrigerate for subsequent use; Fresh shrimp shell is cleaned and removes after impurity, dry 3h at being placed on 100 DEG C, after its drying, after adopting airslide disintegrating mill to be pulverized, get its pulverizing shrimp shell 200g and be placed in 1000mL Erlenmeyer flask, 30g glucose sugar and fermentation liquor of 50mL are added in Erlenmeyer flask to it simultaneously, be uniformly mixed under 300r/min rotating speed; After it mixes, flask is placed in air constant-temperature table, arranging rotating speed is 300r/min, carry out fermentation process 15h, after it has fermented, it is filtered, be 6.5 by deionized water washing filter residue to pH again, and dry 3h at 100 DEG C, be i.e. separable solid-state chitin; Count by weight, choose the solid-state chitin of 20 parts of preparations, 50 parts of acryl resins, the azoisobutyronitrile of 10 parts, benzoyl peroxides of 20 parts, at 80 DEG C, form chitin bottom blended polymer after stirring reaction 20h, then form transparent cambered surface bottom through turning; Count by weight, be 2 μm of natural earth pigments by the particle diameter of the acryl resin of 50 parts, the azoisobutyronitrile of 10 parts, the benzoyl peroxide of 30 parts and 10 parts, 10min is polymerized at 20 DEG C, obtain the polymer coating that viscosity is 8000mPas, again obtained cambered surface bottom is placed in die, the pattern being printed on dope layer is transferred to the iris district of bottom, intermediate primer layer; Add die after being polymerized by the material of bottom same composition, with the speed rotating cavity die of 400r/min, and to its irradiation polymerization 2min, the contact lenses that can obtain a kind of natural chitin extraction have been prepared on top layer the most at last; Described irradiation polymerization device radiation dose rate is 6kGy/h, and irradiation dose is 300kGy.The present invention adopts natural chitin to prepare contact lenses, effectively matches with human cornea, non-stimulated to human body; Contact lenses water retention property is excellent, can wear more than 8h eyes and not occur dry and astringent situation.
Example 2
Choose 12g peptone, 13g beef extract, 9g dusty yeast, 1.5g potassium phosphate, 2.5g dibasic ammonium citrate, 4g sodium acetate, 18g glucose sugar, 0.25g polyoxyethylene sorbitan monooleate, 0.3g magnesium sulfate, above-mentioned material deionized water is settled to 1000mL, is prepared into fluid nutrient medium; Lactobacillus inoculum is carried out activation culture in fresh sterilized non-fat Ruzhong, ensure that its temperature is 36 DEG C, after being cultured to Coagulation of milk, the lactic acid bacteria of cultivation is undertaken being inoculated in fluid nutrient medium by 1% of fluid nutrient medium, carry out cultivation 11h at temperature is 36 DEG C after, refrigerate for subsequent use; Fresh shrimp shell is cleaned and removes after impurity, dry 4h at being placed on 102 DEG C, after its drying, after adopting airslide disintegrating mill to be pulverized, get its pulverizing shrimp shell 200g and be placed in 1000mL Erlenmeyer flask, 30g glucose sugar and fermentation liquor of 50mL are added in Erlenmeyer flask to it simultaneously, be uniformly mixed under 340r/min rotating speed; After it mixes, flask is placed in air constant-temperature table, arranging rotating speed is 300r/min, carry out fermentation process 18h, after it has fermented, it is filtered, be 6.7 by deionized water washing filter residue to pH again, and dry 3.5h at 103 DEG C, be i.e. separable solid-state chitin; Count by weight, choose the solid-state chitin of 30 parts of preparations, 45 parts of acryl resins, the azoisobutyronitrile of 5 parts, benzoyl peroxides of 20 parts, at 110 DEG C, form chitin bottom blended polymer after stirring reaction 22h, then form transparent cambered surface bottom through turning; Count by weight, be 4 μm of natural earth pigments by the particle diameter of the acryl resin of 60 parts, the azoisobutyronitrile of 5 parts, the benzoyl peroxide of 25 parts and 10 parts, 40min is polymerized at 35 DEG C, obtain the polymer coating that viscosity is 100000mPas, again obtained cambered surface bottom is placed in die, the pattern being printed on dope layer is transferred to the iris district of bottom, intermediate primer layer; Add die after being polymerized by the material of bottom same composition, with the speed rotating cavity die of 1000r/min, and to its irradiation polymerization 12min, the contact lenses that can obtain a kind of natural chitin extraction have been prepared on top layer the most at last; Described irradiation polymerization device radiation dose rate is 6kGy/h, and irradiation dose is 300kGy.The present invention adopts natural chitin to prepare contact lenses, effectively matches with human cornea, non-stimulated to human body; Contact lenses water retention property is excellent, can wear more than 8h eyes and not occur dry and astringent situation.
Example 3
Choose 15g peptone, 15g beef extract, 10g dusty yeast, 2g potassium phosphate, 3g dibasic ammonium citrate, 5g sodium acetate, 20g glucose sugar, 0.5g polyoxyethylene sorbitan monooleate, 0.5g magnesium sulfate, above-mentioned material deionized water is settled to 1000mL, is prepared into fluid nutrient medium; Lactobacillus inoculum is carried out activation culture in fresh sterilized non-fat Ruzhong, ensure that its temperature is 37 DEG C, after being cultured to Coagulation of milk, the lactic acid bacteria of cultivation is undertaken being inoculated in fluid nutrient medium by 1% of fluid nutrient medium, carry out cultivation 12h at temperature is 37 DEG C after, refrigerate for subsequent use; Fresh shrimp shell is cleaned and removes after impurity, dry 5h at being placed on 105 DEG C, after its drying, after adopting airslide disintegrating mill to be pulverized, get its pulverizing shrimp shell 200g and be placed in 1000mL Erlenmeyer flask, 30g glucose sugar and fermentation liquor of 50mL are added in Erlenmeyer flask to it simultaneously, be uniformly mixed under 400r/min rotating speed; After it mixes, flask is placed in air constant-temperature table, arranging rotating speed is 300r/min, carry out fermentation process 20h, after it has fermented, it is filtered, be 7.0 by deionized water washing filter residue to pH again, and dry 4h at 105 DEG C, be i.e. separable solid-state chitin; Count by weight, choose the solid-state chitin of 59.9 parts of preparations, 40 parts of acryl resins, the azoisobutyronitrile of 0.01 part, benzoyl peroxides of 0.09 part, at 130 DEG C, form chitin bottom blended polymer after stirring reaction 24h, then form transparent cambered surface bottom through turning; Count by weight, be 5 μm of natural earth pigments by the particle diameter of the acryl resin of 80 parts, the azoisobutyronitrile of 5 parts, the benzoyl peroxide of 5 parts and 10 parts, 60min is polymerized at 50 DEG C, obtain the polymer coating that viscosity is 200000mPas, again obtained cambered surface bottom is placed in die, the pattern being printed on dope layer is transferred to the iris district of bottom, intermediate primer layer; Add die after being polymerized by the material of bottom same composition, with the speed rotating cavity die of 1600r/min, and to its irradiation polymerization 20min, the contact lenses that can obtain a kind of natural chitin extraction have been prepared on top layer the most at last; Described irradiation polymerization device radiation dose rate is 6kGy/h, and irradiation dose is 300kGy.The present invention adopts natural chitin to prepare contact lenses, effectively matches with human cornea, non-stimulated to human body; Contact lenses water retention property is excellent, can wear more than 8h eyes and not occur dry and astringent situation.
Claims (2)
1. natural chitin extraction prepares a method for contact lenses, it is characterized in that concrete preparation process is:
(1) 10 ~ 15g peptone, 10 ~ 15g beef extract, 8 ~ 10g dusty yeast, 1 ~ 2g potassium phosphate, 2 ~ 3g dibasic ammonium citrate, 2 ~ 5g sodium acetate, 15 ~ 20g glucose sugar, 0.1 ~ 0.5g polyoxyethylene sorbitan monooleate, 0.2 ~ 0.5g magnesium sulfate is chosen, above-mentioned material deionized water is settled to 1000mL, is prepared into fluid nutrient medium;
(2) lactobacillus inoculum is carried out activation culture in fresh sterilized non-fat Ruzhong, ensure that its temperature is 36 ~ 37 DEG C, after being cultured to Coagulation of milk, the lactic acid bacteria of cultivation is undertaken being inoculated in fluid nutrient medium by 1% of fluid nutrient medium, carry out cultivation 10 ~ 12h at temperature is 36 ~ 37 DEG C after, refrigerate for subsequent use;
(3) fresh shrimp shell cleaned and remove after impurity, dry 3 ~ 5h at being placed on 100 ~ 105 DEG C, after its drying, after adopting airslide disintegrating mill to be pulverized, get its pulverizing shrimp shell 200g and be placed in 1000mL Erlenmeyer flask, 30g glucose sugar and fermentation liquor of 50mL are added in Erlenmeyer flask to it simultaneously, be uniformly mixed under 300 ~ 400r/min rotating speed;
(4) after it mixes, flask is placed in air constant-temperature table, arranging rotating speed is 300r/min, carry out fermentation process 15 ~ 20h, after it has fermented, it is filtered, then be 6.5 ~ 7.0 by deionized water washing filter residue to pH, and at 100 ~ 105 DEG C, dry 3 ~ 4h, i.e. separable solid-state chitin;
(5) count by weight, choose the solid-state chitin of 20 ~ 59.9 parts of preparations, 40 ~ 50 parts of acryl resins, the azoisobutyronitrile of 0.01 ~ 10 part, benzoyl peroxides of 0.01 ~ 25 part, at 80 ~ 130 DEG C, form chitin bottom blended polymer after stirring reaction 20 ~ 24h, then form transparent cambered surface bottom through turning;
(6) count by weight, be 2 ~ 5 μm of natural earth pigments by the particle diameter of the acryl resin of 50 ~ 80 parts, the azoisobutyronitrile of 0.01 ~ 10 part, the benzoyl peroxide of 0.01 ~ 30 part and 1 ~ 40 part, 10 ~ 60min is polymerized at 20 ~ 50 DEG C, obtain the polymer coating that viscosity is 8000 ~ 200000mPas, again the cambered surface bottom that step (5) is obtained is placed in die, the pattern being printed on dope layer is transferred to the iris district of bottom, intermediate primer layer;
(7) add die after being polymerized by the material of bottom same composition, with the speed rotating cavity die of 400 ~ 1600r/min, and to its irradiation polymerization 2 ~ 20min, the contact lenses that can obtain a kind of natural chitin extraction have been prepared on top layer the most at last.
2. a kind of natural chitin extraction according to claims 1 prepares the method for contact lenses, it is characterized in that: described irradiation polymerization device radiation dose rate is 6kGy/h, and irradiation dose is 300kGy.
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| CN201510576184.0A CN105044924A (en) | 2015-09-11 | 2015-09-11 | Method for preparing contact lenses by means of naturally-extracted chitin |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005036236A2 (en) * | 2003-10-06 | 2005-04-21 | Praful Doshi | Tinted lenses and methods of manufacture |
| CN102863553A (en) * | 2012-04-01 | 2013-01-09 | 金陵科技学院 | Chitosan derivative with cross-linking polymerization and containing drug ligand |
| CN103217809A (en) * | 2013-04-19 | 2013-07-24 | 福建农林大学 | Konjak contact lenses and preparation method thereof |
| CN104592418A (en) * | 2014-12-02 | 2015-05-06 | 林康艺 | Method for extracting chitin from shrimp and crab shells by utilizing co-immobilized mixed bacteria |
-
2015
- 2015-09-11 CN CN201510576184.0A patent/CN105044924A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005036236A2 (en) * | 2003-10-06 | 2005-04-21 | Praful Doshi | Tinted lenses and methods of manufacture |
| CN102863553A (en) * | 2012-04-01 | 2013-01-09 | 金陵科技学院 | Chitosan derivative with cross-linking polymerization and containing drug ligand |
| CN103217809A (en) * | 2013-04-19 | 2013-07-24 | 福建农林大学 | Konjak contact lenses and preparation method thereof |
| CN104592418A (en) * | 2014-12-02 | 2015-05-06 | 林康艺 | Method for extracting chitin from shrimp and crab shells by utilizing co-immobilized mixed bacteria |
Non-Patent Citations (4)
| Title |
|---|
| 李莉: "《微生物基础技术》", 31 October 2010, 武汉理工大学出版社 * |
| 湖南省长沙农业学校: "《食品微生物学》", 31 October 1990, 中国农业出版社 * |
| 董炎明: "《甲壳素化学及应用》", 《大学化学》 * |
| 陈亚: "《提取甲壳素的乳酸菌发酵工艺优化》", 《湖北农业科学》 * |
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