CN103217809A - Konjak contact lenses and preparation method thereof - Google Patents
Konjak contact lenses and preparation method thereof Download PDFInfo
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- CN103217809A CN103217809A CN2013101394523A CN201310139452A CN103217809A CN 103217809 A CN103217809 A CN 103217809A CN 2013101394523 A CN2013101394523 A CN 2013101394523A CN 201310139452 A CN201310139452 A CN 201310139452A CN 103217809 A CN103217809 A CN 103217809A
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- konjaku
- contact lenses
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- konjak
- necked flask
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Abstract
The invention relates to a pair of konjak contact lenses and a preparation method thereof. The preparation method of the konjak contact lenses comprises the steps of: gel solution preparation, degassing, forming and post-processing. Konjak gulcomannan is used as a carrier and is supported by other auxiliaries, the konjak contact lenses are good in gel, hydrophily, antibacterial property, and oxygen permeability, high in transparency, good in elasticity, strong in flexibility, and hard to break. Compared with the traditional contact lens, the konjak contact lenses provided by the invention are antibacterial and a production material is environment-friendly, the security and the use performance are completely fit with the national relevant standard demand. Since the konjak gulcomannan is used as the main material, the contact lenses are low in cost, small in environment pollution, and free from harm to a human body, and fit the modern consumption concepts and market requirements.
Description
Technical field
The present invention relates to a kind of glasses and preparation method thereof, be specifically related to a kind of konjaku contact lenses and preparation method thereof.
Background technology
Along with the A nearsighted person increases year by year, the glasses kind also increases day by day, and what enjoy that the patient pays close attention to is to have all multi-functional contact lenss, and promptly contact lenses are a kind of eyeglasses of correcting defects of vision on the cornea or protecting eyes that are worn over.It is bringing very big improvement to the patient aspect outward appearance, convenience and the effect, and special in treatment
Effect has also been brought into play in the illness in eye aspect.The potential number that China need wear glasses should account for 50% of total number of persons, and domestic glasses market development is enormously potential, particularly contact lenses.
Application number is that (applying date: 1987.07.18) this invention aims to provide a kind of improved soft contact lens material that exists with form of hydrogels, and said material is with the forming polymer of hydroxyalkyl acrylate that contains fluorochemical monomer, acrylic or methacrylic acid and N-vinyl lactam for 87105002 patent of invention " fluorine-containing soft contact lens hydrogels ".This polymkeric substance also can contain other hydrophilic and/or hard hydrophobic monomers, crosslinking chemical and ultraviolet light absorber again.The contact lenses that are prepared into by these materials combinations have the hydrate water of high-load, and high wettability has extra high oxygen transmission rate, can stop the deposition of protein and other forms of adhesion residue.But the hydrate water of high-load makes eyeglass break easily, and the affiliation that adds of fluorine raises the cost harmful with fluoride.
Application number is 88108053.5 patent of invention " the hydrophilic colored contact lenses " (applying date: 1988.11.23) a kind of method that is used to make colored hydrophilic contact lens.Provide a kind of by be substantially free of functional group-COOH ,-OH ,-NH-R(wherein R be hydrogen or C
1To C
8Alkyl) ,-contact lenses that the hydrophilic polymer of NCO and epoxy radicals constitutes.At least a portion of this contact lens surface coating one deck colour-wash, this coating comprises at least a pigment, have several be selected from-COOH ,-OH and-NH-R(wherein R be hydrogen or C
1To C
8Alkyl) adhesive polymer of at least a functional group in, and a kind of each molecule has the additional compound of 2-NCO group at least.Because these contact lenses are made of hydrophilic polymer, so strengthened the comfort level of glasses.But the surface has been coated with one deck colour-wash, has reduced transparency, has strengthened the ill probability of eyes.
Application number is that (date of application: 2002.12.03) this invention has been produced the contact lenses of coating by at least a portion that provides glasses and use coating derived from binder component and activating component to apply lens surface for 02824472.9 patent of invention " contact lenses of coating and manufacture method thereof ".Binder component comprises each polymer molecule and has at least one epoxide group and the cohesive polymers component of at least two epoxide groups preferably.Activating component can form the cross-linked polymer component with the cohesive polymers component reaction.The method and the coating composition that apply glasses also are provided.But coating can strengthen the sense of discomfort of eyes and have the people that lens coating is had allergic reaction.
Summary of the invention
The purpose of this invention is to provide a kind of konjaku contact lenses.Utilize gelation, the antibiotic property of konjaku glucomannan and be aided with other plastifier (glycerine), synergistic agent (shitosan, sodium alginate etc.) is made soft antibiotic contact lenses.
The preparation method of konjaku contact lenses of the present invention, operation steps is as follows:
(1) coagulant liquid preparation: put konjaku powder behind the purifying in there-necked flask, after multiple adds 95-105 water doubly by weight, put there-necked flask in water bath with thermostatic control, described there-necked flask is equipped with stirrer and condenser; Adopt stirring machine 150r/min to be heated to 45 ℃ while stirring, insulation is no less than 2h, filter then, the aqueous solution that adds the potassium persulfate of initiating agent 1.5mol/mL, the monomer acrylic acid aqueous solution that adds 1.2mol/mL behind 10 min, and press paraffin, the glycerine of 0.1%-0.3% and the synergistic agent of 3%-5% that adds 0.7%-0.9% with the percentage by weight of water, and be stirred to whole dissolvings, standby; Described synergistic agent is shitosan or sodium alginate; Konjaku powder behind the described purifying refers to that granularity is that the particle of 0.125～0.425mm konjaku powder is no less than 90%;
(2) degassing: the coagulant liquid in the step (1) is placed the centrifugal degassing of hydro-extractor 3000r/min 15-25min, obtain konjaku glucomannan mixed gel liquid, standby;
(3) moulding: use the injection moulding machine of contact lens mould,, and under ultraviolet irradiation, form solid-state eyeglass with the konjaku glucomannan mixed gel liquid injection mold for frames of step (2); The model of described contact lens mold injection molding machine: B29C45/03; Finished diameter: 14.00mm or 14.50mm become the terpinyl arc: 8.4-8.7mm, center thickness: 0.03-0.06mm;
Described contact lens is made by computer program; This technology is that konjaku glucomannan mixed gel liquid raw material is splashed in the disposable mould of high speed rotating, the sense of rotation of the amount of splashing into and mould, speed meet design by the comprehensive accurate control of computer with the parameters such as shape, thickness and diopter that guarantee eyeglass; In the rotary course under ultraviolet irradiation liquid charging stock generation photopolymerization reaction, form solid-state eyeglass.
(4) back processing: the eyeglass to step (3) moulding carries out edge trimming, carries out the hydration demoulding and sterilization after having revised.
The present invention also protects the konjaku contact lenses with method for preparing.
Konjaku contact lenses of the present invention are carrier with the konjaku glucomannan and be aided with other auxiliary agents, have good gelation, water wettability, antibiotic property, oxygen permeability and transparency height, good springiness, pliability by force, easy fracture not.Compare with traditional contact lenses, have antibiotic effect, and produce material environment friendly.Security and usability meet the relative national standards requirement fully, are main material with the konjaku glucomannan, and it is low, low in the pollution of the environment to have a production cost, to advantages such as human body do not injure, meet the modern consumption concept and the market demand.
Konjaku contact lenses of the present invention and common soft contact lens performance comparison result are as shown in table 1.
Table 1 konjaku contact lenses of the present invention and common soft contact lens performance comparison result
Annotate: the method for testing of table 1 performance index is as follows:
(1) water percentage: konjaku contact lenses and common soft contact lens are soaked 24h in distilled water, make its suction balance, blot the moisture on surface gently with filter paper, W weighs
Hygrometric stateMaterial after will weighing then places 105 ℃ of baking ovens, dries to constant weight, is cooled to room temperature, and W weighs
Dry stateBe calculated as follows water percentage:
EWC %=(W
Hygrometric state-W
Dry state)/W
Hygrometric state* 100%;
(2) transparency: two kinds of contact lenses are immersed in soak 24h in the distilled water respectively, reach the suction balance after, blot surface moisture with filter paper, be reference with distilled water, under 450nm～700nm, measure the average transmittance of material with 721 type spectrophotometers.
(3) antibiotic property: combination
GB11417.2-1989Standard Selection for the examination bacterium and mould.
(4) tensile strength: under 32 ℃ of room temperatures, 500nm/min condition, measure two kinds of contact lenses tensile strength with electronic tensile machine.
(5) oxygen permeability: owing to do not have blood vessel on the eye cornea, the contact lens material will have certain oxygen permeability could guarantee not anoxic of eyes.Discover the oxygen flow ability of hydrogel contact lens material and its water cut
Be directly proportional, can judge the quality of oxygen permeability with the size of water percentage.
The result of contrast test shows, with the every excellent performance of konjaku contact lenses of the present invention, its index is all above commercially available common contact lenses, alternative existing contact lenses.
Embodiment
The present invention is further elaborated below in conjunction with embodiment.
(1) coagulant liquid preparation: put konjaku powder behind the purifying in there-necked flask, add the water of 100 times of weights after, put there-necked flask in water bath with thermostatic control, described there-necked flask is equipped with stirrer and condenser; Adopt stirring machine 150r/min to be heated to 45 ℃ while stirring, insulation 2h, make its principal ingredient swelling, filter, add the aqueous solution of the potassium persulfate of initiating agent 1.5mol/mL, add the monomer acrylic acid aqueous solution of 1.2mol/mL behind 10 min, and by adding 0.8% paraffin and 0.2% glycerine with the percentage by weight of water, 4% synergistic agent is stirred to whole dissolvings, and is standby;
(2) degassing: the coagulant liquid in the step (1) is placed hydro-extractor, and the centrifugal degassing of 3000r/min 20min obtains konjaku glucomannan mixed gel liquid;
(3) moulding: use the injection moulding machine of contact lens mould, step (2) konjaku glucomannan mixed gel liquid is injected mold for frames, and under ultraviolet irradiation, form solid-state eyeglass; The model of described contact lens mold injection molding machine: B29C45/03; Finished diameter: 14.00mm; Become terpinyl arc: 8.5mm; Center thickness: 0.05mm;
(4) back processing: the eyeglass to moulding carries out edge trimming, carries out the hydration demoulding after having revised, and uses contact lens care solution that eyeglass is carried out disinfection, and is cut into finished product by all size then; Also can be as required, eyeglass carried out painted processing after, be cut into finished product by all size.
The above only is preferred embodiment of the present invention, and all equalizations of being done according to the present patent application claim change and modify, and all should belong to covering scope of the present invention.
Claims (3)
1. the preparation method of konjaku contact lenses is characterized in that step is as follows:
(1) coagulant liquid preparation: put konjaku powder behind the purifying in there-necked flask, after multiple adds 95-105 water doubly by weight, put there-necked flask in water bath with thermostatic control, described there-necked flask is equipped with stirrer and condenser; Adopt stirring machine 150r/min to be heated to 45 ℃ while stirring, insulation is no less than 2h, filter then, the aqueous solution that adds the potassium persulfate of initiating agent 1.5mol/mL, the monomer acrylic acid aqueous solution that adds 1.2mol/mL behind 10 min, and press paraffin, the glycerine of 0.1%-0.3% and the synergistic agent of 3%-5% that adds 0.7%-0.9% with the percentage by weight of water, and be stirred to whole dissolvings, standby; Described synergistic agent is shitosan or sodium alginate; Konjaku powder behind the described purifying refers to that granularity is that the particle of 0.125～0.425mm konjaku powder is no less than 90%;
(2) degassing: the coagulant liquid in the step (1) is placed the centrifugal degassing of hydro-extractor 3000r/min 15-25min, obtain konjaku glucomannan mixed gel liquid, standby;
(3) moulding: use the injection moulding machine of contact lens mould,, and under ultraviolet irradiation, form solid-state eyeglass with the konjaku glucomannan mixed gel liquid injection mold for frames of step (2); The model of described contact lens mold injection molding machine: B29C45/03; Finished diameter: 14.00mm or 14.50mm become the terpinyl arc: 8.4-8.7mm, center thickness: 0.03-0.06mm;
(4) back processing: the eyeglass to step (3) moulding carries out edge trimming, carries out the hydration demoulding and sterilization after having revised.
2. the preparation method of a kind of konjaku contact lenses according to claim 1 is characterized in that step is as follows:
(1) coagulant liquid preparation: put konjaku powder behind the purifying in there-necked flask, add the water of 100 times of weights after, put there-necked flask in water bath with thermostatic control, described there-necked flask is equipped with stirrer and condenser; Adopt stirring machine 150r/min to be heated to 45 ℃ while stirring, insulation 2h, make its principal ingredient swelling, filter, add the aqueous solution of the potassium persulfate of initiating agent 1.5mol/mL, add the monomer acrylic acid aqueous solution of 1.2mol/mL behind 10 min, and by adding 0.8% paraffin and 0.2% glycerine with the percentage by weight of water, 4% synergistic agent is stirred to whole dissolvings, and is standby;
(2) degassing: the coagulant liquid in the step (1) is placed hydro-extractor, and the centrifugal degassing of 3000r/min 20min obtains konjaku glucomannan mixed gel liquid;
(3) moulding: use the injection moulding machine of contact lens mould, step (2) konjaku glucomannan mixed gel liquid is injected mold for frames, and under ultraviolet irradiation, form solid-state eyeglass; The model of described contact lens mold injection molding machine: B29C45/03; Finished diameter: 14.00mm; Become terpinyl arc: 8.5mm; Center thickness: 0.05mm;
(4) back processing: the eyeglass to moulding carries out edge trimming, carries out the hydration demoulding after having revised, and uses contact lens care solution that eyeglass is carried out disinfection.
3. by the konjaku contact lenses of the method for claim 1 or 2 preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310139452.3A CN103217809B (en) | 2013-04-19 | 2013-04-19 | Konjak contact lenses and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310139452.3A CN103217809B (en) | 2013-04-19 | 2013-04-19 | Konjak contact lenses and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN103217809A true CN103217809A (en) | 2013-07-24 |
| CN103217809B CN103217809B (en) | 2014-06-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310139452.3A Expired - Fee Related CN103217809B (en) | 2013-04-19 | 2013-04-19 | Konjak contact lenses and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105044924A (en) * | 2015-09-11 | 2015-11-11 | 江苏振宇环保科技有限公司 | Method for preparing contact lenses by means of naturally-extracted chitin |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5114035A (en) * | 1974-07-24 | 1976-02-04 | Koken Kk | KONNYAKUKOKARAKONTAKUTORENZUNO SEIZOHO |
| JPH05194603A (en) * | 1992-01-23 | 1993-08-03 | Asahi Chem Ind Co Ltd | Transparent konjakmannan gel |
| JPH06317768A (en) * | 1993-05-07 | 1994-11-15 | Asahi Chem Ind Co Ltd | Care product for contact lens containing glucomannan |
| CN1401678A (en) * | 2002-09-12 | 2003-03-12 | 武汉大学 | Konjaku plucosidopolyose graft copolymer, preparing process and use thereof |
-
2013
- 2013-04-19 CN CN201310139452.3A patent/CN103217809B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5114035A (en) * | 1974-07-24 | 1976-02-04 | Koken Kk | KONNYAKUKOKARAKONTAKUTORENZUNO SEIZOHO |
| JPH05194603A (en) * | 1992-01-23 | 1993-08-03 | Asahi Chem Ind Co Ltd | Transparent konjakmannan gel |
| JPH06317768A (en) * | 1993-05-07 | 1994-11-15 | Asahi Chem Ind Co Ltd | Care product for contact lens containing glucomannan |
| CN1401678A (en) * | 2002-09-12 | 2003-03-12 | 武汉大学 | Konjaku plucosidopolyose graft copolymer, preparing process and use thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105044924A (en) * | 2015-09-11 | 2015-11-11 | 江苏振宇环保科技有限公司 | Method for preparing contact lenses by means of naturally-extracted chitin |
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| CN103217809B (en) | 2014-06-25 |
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Granted publication date: 20140625 Termination date: 20180419 |