CN105031419B - A kind of composition and preparation method thereof with effects of relieving alcoholism and protecting liver - Google Patents
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Abstract
The invention discloses a kind of composition and preparation method thereof with effects of relieving alcoholism and protecting liver, the composition with effects of relieving alcoholism and protecting liver are made of the ten taste medicinal material such as pueraria lobata, hoveniae semoveniae semen, red bayberry, hawthorn, malt, Poria cocos, semen ziziphi spinosae, fingered citron, Gorgon fruit, chrysanthemum.Preparation method comprises the following steps that: choosing each component raw material by composite formula, it is extracted using water or alcohol-water mixed solvent, extracting solution concentration, mixes, dry, obtain the composition, and proper auxiliary materials can be added as needed, corresponding oral preparation, such as tablet, capsule is made, granule, oral solution etc..The selected dual-purpose of drug and food medicinal material of composition of the present invention is formulated, and being verified by experiments has effects that Antialcoholic liver-protecting, can be applied in correlation function food and drug.
Description
Technical field
The present invention relates to a kind of compositions with effects of relieving alcoholism and protecting liver, and present invention simultaneously relates to the effects of relieving alcoholism and protecting liver
The preparation method of composition belongs to health food and medicine field.
Technical background
Drinking is a kind of universal cooking culture phenomenon in the whole world.E-at pleasure, drink with measure can be such that the blood circulation of human body accelerates, essence
Mind loosens, and is easy to fall asleep, be good for your health；But if excessive drinking, it will cause gastric mucosa and be damaged, compromised liver function,
Central nervous system paralysis, lethargic sleep etc., long-term alcohol may excessively further result in cirrhosis, hypertension, intelelectual deterioration etc.
Disease constitutes human health and injures.On the other hand, due to unique organ that liver is alcohol metabolism, long-term alcohol also can be right
Liver function has an impact, serious person even results in the diseases such as alcoholic liver.Therefore, there is relieving alcoholism and protecting liver using some, alleviates wine
Uncomfortable functional food, drug have specific market application value afterwards.
The present inventor is developed for the first time by numerous studies and experiment by the 10 taste medicine such as pueraria lobata, hoveniae semoveniae semen, red bayberry, hawthorn
The new formula for eating dual-use materials composition, has the effects that specific relieving alcoholism and protecting livers.It is further furtherd investigate, completes this hair
It is bright.
Summary of the invention
The object of the present invention is to provide a kind of compositions with effects of relieving alcoholism and protecting liver.
The composition is according to parts by weight, composed of the following components: 1-20 parts of pueraria lobata, 1-20 parts of hoveniae semoveniae semen, red bayberry 1-
20 parts, 1-20 parts of hawthorn (stir-fry), 1-20 parts of malt (stir-fry), 1-20 parts of Poria cocos, 1-20 parts of semen ziziphi spinosae, 1-20 parts of fingered citron, Gorgon fruit 1-
10 parts, 1-10 parts of chrysanthemum.
The composition according to parts by weight, can be optimized for following components composition: 2-15 parts of pueraria lobata, 2-15 parts of hoveniae semoveniae semen,
2-15 parts of red bayberry, 2-15 parts of hawthorn (stir-fry), 2-15 parts of malt (stir-fry), 2-15 parts of Poria cocos, 2-15 parts of semen ziziphi spinosae, 2-15 parts of fingered citron,
1-5 parts of Gorgon fruit, 1-5 parts of chrysanthemum.
The composition according to parts by weight, can further be optimized for following components composition: 3-10 parts of pueraria lobata, hoveniae semoveniae semen 3-
10 parts, 3-10 parts of red bayberry, 3-10 parts of hawthorn (stir-fry), 3-10 parts of malt (stir-fry), 2-10 parts of Poria cocos, 2-10 parts of semen ziziphi spinosae, fingered citron 2-5
Part, 1-5 parts of Gorgon fruit, 1-5 parts of chrysanthemum.
The present invention further provides the methods of the preparation extract with effects of relieving alcoholism and protecting liver, including following technique step
It is rapid: to choose each component raw material by composite formula, extracted using water or alcohol-water mixed solvent, extracting solution concentration mixes
It closes, it is dry, obtain the composition.
In the processing step, each component raw material is optionally individually extracted or is mixed extraction, and extracting mode can
It is extracted optionally with water or alcohol-water mixed solvent, the preferred 60-80% ethyl alcohol of alcohol-water mixed solvent.Preferably,
Red bayberry is individually adopted and is extracted with water.
Composition of the present invention with effects of relieving alcoholism and protecting liver proper auxiliary materials can be added as needed, corresponding mouth is made
Formulation, such as tablet, capsule, granule, oral solution etc..
Composition of the present invention with effects of relieving alcoholism and protecting liver passes through selected traditional dual-purpose of drug and food with hepatoprotective effect
Medicinal material, by studying repeatedly and test-meal, finishing screen select this composition optimization of C/C composites.Animal experiment proves that having prevention
The effects of drunk, relieving alcoholism and protecting livers lipid-loweringing.Pass through crowd's test-meal, it was demonstrated that the effective percentage that pre- preventing drunkenness, mitigation are still drank after a night is about 80%.
By process optimization, the preparation method has efficiently extracted each component active principle, and concise in technology, strong operability are easy to
Realize industrialization amplification.
The content of present invention is completed by lot of experiments and process optimization analysis, with the progress of following specific embodiments
Explanation.
Specific embodiment
Composition of the present invention with effects of relieving alcoholism and protecting liver is manufactured by method represented by following embodiment, institute
The method being related to is the technological means that those skilled in the art will appreciate that and use.But following embodiment must not be interpreted as
The limitation to this field invention claim in all senses.
Embodiment 1: the preparation (1) of composite formula one
Formula: it is calculated by weight as, 10 parts of pueraria lobata, 10 parts of hoveniae semoveniae semen, 10 parts of red bayberry, 8 parts of hawthorn (stir-fry), malt (stir-fry)
8 parts, 5 parts of Poria cocos, 5 parts of semen ziziphi spinosae, 5 parts of fingered citron, 3 parts of Gorgon fruit, 3 parts of chrysanthemum.
Preparation process: by the above formula, red bayberry individually uses 10 times of water refluxing extractions 2 times, and 1 hour every time, extracting solution concentration；
Remaining nine taste component with 15 times water refluxing extraction 2 times, 2 hours every time, extracting solution concentration was added red bayberry concentrate, mixes, spraying
Drying is to get the composition (two power).
Embodiment 2: the preparation (2) of composite formula one
Formula: with embodiment 1.
Preparation process: by the above formula, red bayberry individually uses 10 times of water refluxing extractions 2 times, and 1 hour every time, extracting solution concentration；
Remaining nine taste component is extracted 2 times with 10 times of 60% alcohol reflux, and 2 hours every time, extracting solution concentration was added red bayberry concentrate, mixes
It is even, 80 degree of forced air dryings to get.
Embodiment 3: the preparation (3) of composite formula one
Formula: with embodiment 1.
Preparation process: by the above formula, red bayberry individually uses 10 times of water refluxing extractions 2 times, and 1 hour every time, extracting solution concentration；
Remaining nine taste component with 10 times water refluxing extraction 1 time, then with 80% alcohol reflux extract 1 time, every time extract 2 hours, extracting solution
Concentration, be added red bayberry concentrate, mix, 80 degree of forced air dryings to get.
Embodiment 4: the preparation (4) of composite formula one
Formula: with embodiment 1.
Preparation process: 1 resulting composition of Example is added the flavoring agents such as appropriate amount of essence, Sucralose, appropriate mountain is added
The auxiliary materials such as pears sugar alcohol, lactose, microcrystalline cellulose, magnesium stearate mix, tabletting, and 2 grams/piece of two power chewable tablets are made in coating.
Embodiment 5: the preparation (5) of composite formula one
Formula: with embodiment 1.
Preparation process: 1 resulting composition of Example is added the flavoring agents such as appropriate amount of essence, Sucralose, appropriate mountain is added
Pears sugar alcohol, lactose, microcrystalline cellulose are auxiliary material, are mixed, softwood processed, drying, magnesium stearate mixing are added, granule is made.
Embodiment 6: the preparation (6) of composite formula one
Formula: with embodiment 1.
Preparation process: appropriate amount of essence, the flavoring agents such as Sucralose is added in 1 resulting composition of Example, and water, white is added
Granulated sugar, fruit juice are auxiliary material, and oral solution is made in dissolution, stirring, filtering.
Embodiment 7: the preparation of composite formula two
Formula: it is calculated by weight as, 15 parts of pueraria lobata, 15 parts of hoveniae semoveniae semen, 10 parts of red bayberry, 10 parts of hawthorn (stir-fry), malt
10 parts of (stir-fry), 8 parts of Poria cocos, 8 parts of semen ziziphi spinosae, 5 parts of fingered citron, 5 parts of Gorgon fruit, 1 part of chrysanthemum.
Preparation process: with embodiment 1.
Embodiment 8: the preparation of composite formula three
Formula: it is calculated by weight as, 20 parts of pueraria lobata, 20 parts of hoveniae semoveniae semen, 20 parts of red bayberry, 15 parts of hawthorn (stir-fry), malt
15 parts of (stir-fry), 10 parts of Poria cocos, 5 parts of semen ziziphi spinosae, 10 parts of fingered citron, 5 parts of Gorgon fruit, 3 parts of chrysanthemum.
Preparation process: with embodiment 2.
Test example 1: anti-intoxication pharmacodynamic test
KM mouse (male and female dual-purpose) 50 is taken, model group is randomly divided into, positive drug sea Wang Jin cup group (1.5g/kg), implements
1 sample of example (two power) low, middle and high dose groups (0.3,0.6,1.2g/kg), every group 10.First gastric infusion, stomach-filling after 30min
To wine, vina amount 0.3ml/20g is given.It is sleep index with righting reflex loss, calculates tolerance time (from ethyl alcohol stomach-filling to righting
The time of areflexia) and liquor-saturated sleep the time (time from righting reflex loss to recovery).Test result is shown in Table 1.
1 liang of power of table is to mouse tolerance time and the liquor-saturated influence for sleeping the time
Note: compared with model group, * P < 0.05, * * P < 0.01.Similarly hereinafter.
Experimental result shows that two power low, middle and high dose groups can significantly improve mice drunk tolerance time, shortens simultaneously
The liquor-saturated of mouse sleeps the time, there is significant difference (P < 0.05, P < 0.01) compared with model group.
Test example 2: pharmacodynamic test of relieving the effect of alcohol
Take KM mouse 50, be randomly divided into 1 liang of model group, positive drug sea Wang Jin cup group (1.5g/kg), embodiment power it is low,
Middle and high dosage group (0.3,0.6,1.2g/kg), every group 10.First stomach-filling gives vina amount 0.3ml/20g to wine, gives after drinking at once
Administration.With righting reflex loss be sleep index, calculate tolerance time (time from ethyl alcohol stomach-filling to righting reflex loss) and
It is liquor-saturated to sleep the time (time from righting reflex loss to recovery).Test result is shown in Table 2.
2 liang of power of table are to mouse tolerance time and the liquor-saturated influence for sleeping the time
Experimental result shows that two power are high, middle dose group can significantly improve mice drunk tolerance time, while shorten mouse
It is liquor-saturated sleep the time, have significant difference (P < 0.05) compared with model group, show two power have good antialcoholism action.
3 liver protection of test example test
Using KM mouse (18-22 grams) 50, it is basic, normal, high to be randomly divided into 1 liang of model group, negative control group, embodiment power
Dosage group (0.3,0.6,1.2g/kg), every group 10.Given the test agent is given in daily stomach-filling, and negative and model control group is given pure
Water purification is continuously given 30 days.After with 50% dehydrated alcohol stomach-filling 12ml/kg cause liver injury model, negative control group is given
Give pure water.It takes a blood sample in mouse orbit rear vein beard, separates serum, Triglycerides in Serum is detected using ELISA kit
(TG), the content of very low density lipoprotein (VLDL).Take hepatic tissue to do histotomy, observation fat drips liver distribution and
Area is no more than 0,1/4,2/4,3/4,4/4 to corresponding scoring 0-4 based on the liver cell containing fat drips.As a result as follows.
The measurement of 3 Serum Indexes of table
4 histopathologic examination's result of table
The result shows that: model control group TG and VLDL content compared with negative control group increases statistically significant (P <
0.05), indicate that alcoholic liver injury model is set up；It is equal to take TG, VLDL activity or content in two power low, middle and high dose groups serum
It reduces, shows that the index result is positive.Model control group steatosis degree exacerbation compared with negative control group has statistics meaning
Adopted (P < 0.05) indicates that model is set up；Compared with model control group, steatosis degree mitigates each dosage group of two power, is judged as
Positive findings.Test result shows that two power can reduce alcohol-induced mouse liver injury.
4 human feeding trial of test example
For further prove the present invention to people after drinking and the influence for various physiological reactions of being still drank after a night, with what is prepared in embodiment 4
Two power chewable tablets will test 20 people of volunteer, the age 21-40 years old, male 12 people, 8 people of female were randomly divided into two groups, one group as sample
It is negative group, one group is test group.Half an hour eats bread 100g before testing, and test group takes two power chewable tablets 2 after half an hour
Grain, feminine gender group are not eaten, and capacity for liquor as defined in experiment is drunk after 30min, every test is completed before second day 10:00.One week
After removing phase, two groups of cross exchangeds are carried out.The various indexs being still drank after a night are counted, the results are shown in Table.
5 liang of power human experiments of table negative group data of reaction test result (%) of being still drank after a night can increase
The result shows that: experiments have shown that the present invention can improve various undesirable physiological reactions after drinking, especially to it is tired,
The physiological reactions such as anorexia, dizzy improve significantly, and the state of mind also takes an evident turn for the better, and further prove the present invention
The mood after drinking and somatic reaction of people can be improved afterwards, and sleepiness can be mitigated.
Claims (4)
1. a kind of composition with effects of relieving alcoholism and protecting liver, it is characterised in that by 1-20 parts of pueraria lobata, 1-20 parts of hoveniae semoveniae semen, red bayberry 1-
20 parts, 1-20 parts of stir-baked FRUCTUS CRATAEGI, 1-20 parts of coloured malt, 1-20 parts of Poria cocos, 1-20 parts of semen ziziphi spinosae, 1-20 parts of fingered citron, 1-10 parts of Gorgon fruit,
1-10 parts of chrysanthemum compositions；The preparation method of the composition is prepared by the following steps acquisition: choosing each component by composite formula
Raw material, red bayberry, which is individually adopted, to be extracted with water and is concentrated, remaining component raw material using water or alcohol-water mixed solvent extract with it is dense
Contracting, mix with red bayberry concentrate, dry to get.
2. the composition according to claim 1 with effects of relieving alcoholism and protecting liver is preparing the application in food.
3. the composition according to claim 1 with effects of relieving alcoholism and protecting liver is preparing the application in health food.
4. the composition according to claim 1 with effects of relieving alcoholism and protecting liver is preparing the application in drug.
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| CN106362117A (en) * | 2016-10-25 | 2017-02-01 | 深圳市华岁堂健康药业有限公司 | Traditional Chinese medicine composition capable of dispelling alcohol effect and nourishing liver and preparation method thereof |
| CN107897924A (en) * | 2017-12-04 | 2018-04-13 | 德兴市宋氏葛业有限公司 | A kind of kudzuvine root starch electuary for liver-protecting sobering up and preparation method thereof |
| CN112262900A (en) * | 2020-09-02 | 2021-01-26 | 岳康医疗生物科技有限公司 | Formula and preparation method of instant solid beverage for sobering up and body building |
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| CN1088830A (en) * | 1993-06-09 | 1994-07-06 | 鲁学智 | Sober-up nutrition granules and processing technology thereof |
| CN1448166A (en) * | 2002-04-03 | 2003-10-15 | 顾奎琴 | Pure natural infusion for relieving alcoholism and protecting liver and prep. thereof |
| CN103689724A (en) * | 2013-12-17 | 2014-04-02 | 缙云县天然植物养生研究所 | Functional drink for decreasing internal heat, invigorating stomach and protecting liver and preparation technology thereof |
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- 2015-08-18 CN CN201510505798.XA patent/CN105031419B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088830A (en) * | 1993-06-09 | 1994-07-06 | 鲁学智 | Sober-up nutrition granules and processing technology thereof |
| CN1448166A (en) * | 2002-04-03 | 2003-10-15 | 顾奎琴 | Pure natural infusion for relieving alcoholism and protecting liver and prep. thereof |
| CN103689724A (en) * | 2013-12-17 | 2014-04-02 | 缙云县天然植物养生研究所 | Functional drink for decreasing internal heat, invigorating stomach and protecting liver and preparation technology thereof |
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| CN105031419A (en) | 2015-11-11 |
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