CN105012627B - Stomach strengthening and digestion promoting capsule and preparation method thereof - Google Patents
Stomach strengthening and digestion promoting capsule and preparation method thereof Download PDFInfo
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of preparation methods of stomach strengthening and digestion promoting capsule, include the following steps：1), the screening and pretreatment of raw material；2) it is 5~8% that Chinese yam after hawthorn, pretreatment after bitter dish, pretreatment after deer treasure, pretreatment, is dried under vacuum to moisture weight content respectively；3), dispensing：It is crushed to 60~80 mesh of sieving after 45~55 parts of dry deer treasures, 25~35 parts of dry bitter dish, 15~25 parts of dry hawthorn, 15~20 parts of dry Chinese yams are mixed；Obtain mixed powder；4) it, by mixed powder after sterilization, recycles capsule to carry out sterile filling, sealing, obtains stomach strengthening and digestion promoting capsule.The capsule is the traditional Chinese medicine health capsule made of pure natural substance, is free of any chemicals, is easily absorbed by the body, and helps to improve digestive system function, spleen is supported in stomach invigorating, is promoted digestion, is improved a poor appetite.
Description
Technical field
The invention belongs to health medicine processing technique fields, are related to the preparation method of stomach strengthening and digestion promoting capsule, more particularly to river deer
Several crude drug compositions such as treasured efficiently use.
Background technology
Indigestion is a kind of clinical symptom grouping, is by the disease caused by gastric motility disorder, also not including peristole power
Strong indigestion and esophageal reflux disease.Symptoms are to have epigastric discomfort or pain, glutted, heartburn (anti-by spells
Acid), belch etc..Often it is reluctant to feed because of the discomfort such as uncomfortable in chest, early full sense, abdominal distension, is not easy to sleep peacefully at night, often there is nightmare after sleeping.
Drug currently on the market is Western medicine mostly, and long-term use will produce certain toxic side effect.
Deer treasure is civil alleged river deer milk or river deer breast block, belongs to rare rare medicinal material, is taken from nursing period children river deer glandular stomach
The breast product block gone out.The protein content for detecting deer treasure through authoritative institution's analytical test contains taurine and Soviet Union's ammonia simultaneously up to 39%
17 kinds of amino acid such as acid, wherein 7 kinds are human body essential amino acid, and content is higher than general dairy produce.The calcareous of deer treasure contains
Amount it is higher, every 100 grams of dry powder contain 959.5mg, copper, manganese content be other food several times, zinc, the content of magnesium and dairy condition
When.By causing the research of mice with spleen deficiency to have shown that the vigor of murine protein enzyme can be improved in deer treasure, and can highly significant intemperance of taking food
Improve mice serum gastrin content in ground.The measurement of mouse small intestine propulsion functions is shown, deer treasure can be obviously promoted small bowel peristalsis.
Accordingly it is found that deer treasure can stimulate the secretion of gastrin, and hydrochloric acid in gastric juice, pepsin etc. are adjusted by intestinal hormones such as gastrins
Digestive ferment and gastrointestinal motility, reach therapeutic effect.Deer treasure is warm-natured, and sweet taste has the work(of strengthening the spleen and stomach, promoting digestion, extra-nutrition
Effect can improve digestion, adjust spleen and stomach function and promote child development, be the valuable medicinal material that there is clinical value in pole simply, treat
Effect is notable, there is good potential applicability in clinical practice.
Bitter dish, scientific name field pennycress (Patrinia villosa) are patrinia herb, and perennial herb, up to 1.5m have
Smelly sauce gas, rhizome, root and herb can be used as medicine, bitter in taste, pungent, cool, tool clearing heat and promoting diuresis, removing toxic substances apocenosis, it is promoting blood circulation and removing blood stasis, clear away heart-fire
Calm the nerves and other effects, it is clinically widely used general.Contain 17 kinds of amino acid per the fresh and tender cauline leafs of 100g, total amount reaches 14995.69mg, dimension
Raw element C 42.65mg, vitamin B 20.22mg, B- carrotene 8.36mg, acetic acid 75.8mg, malic acid 92.77mg, at the same it is rich
The various trace elements such as iron content, manganese, potassium, calcium, magnesium.Studies have shown that bitter dish have a promotion small bowel peristalsis, pre- anti-diarrhea, anti-constipation
Effect, function factor may be bitter dish polysaccharide, tannin and dietary fiber.
Hawthorn also known as hawthorn, large-fruited Chinese hawthorn, rose family hawthorn.Hawthorn is also spleen benefiting and stimulating the appetite, relieving dyspepsia, promoting blood circulationization
The good medicine of the stasis of blood.
Chinese yam is equally used as a kind of Chinese medicine, has heat-clearing, removing toxic substances, hypoglycemic, adjusting immunity of organisms, promotion enteron aisle
The effects that digestion.
Deer treasure is as a kind of crude drug and has good edible safety, has high utility value, also,
River deer has been realized in large-scale cultivation in one band of Jiangsu and Zhejiang Provinces, and live body takes newborn technology gradually ripe, so the health care of exploitation deer treasure
Food and formation industrialization continuous production are most important.But deer treasure price and its costliness, it is unfavorable for the marketization of product.
Invention content
The technical problem to be solved in the present invention is to provide a kind of preparation method of stomach strengthening and digestion promoting capsule, which is by pure day
Traditional Chinese medicine health capsule made of right substance, is free of any chemicals, is easily absorbed by the body, and helps to improve digestive system work(
Can, spleen is supported in stomach invigorating, is promoted digestion, is improved a poor appetite.
In order to solve the above technical problem, the present invention provides a kind of stomach strengthening and digestion promoting capsules, by the component of following parts by weight
Composition：
15~20 parts of 45~55 parts of deer treasure, 25~35 parts of bitter dish, 15~25 parts of hawthorn and Chinese yam.
The present invention goes back while providing the preparation method of above-mentioned stomach strengthening and digestion promoting capsule, includes the following steps：
1), the screening and pretreatment of raw material：
Bitter dish select fresh leaf, and cleaned, chopping, bitter dish after must pre-processing；
Hawthorn is through peeling, cleaning, chopping, hawthorn after must pre-processing；
Chinese yam is through peeling, cleaning, chopping, Chinese yam after must pre-processing；
Deer treasure is fresh or freezing deer treasure；
Remarks explanation：Above-mentioned pretreatment mode belongs to routine techniques；
2) Chinese yam after hawthorn, pretreatment after bitter dish, pretreatment after deer treasure, pretreatment, is dried under vacuum to moisture weight respectively
It is 5~8% to measure content；To which deer treasure, dry bitter dish, dry hawthorn, dry Chinese yam must be dried respectively；
3), dispensing：
By 45~55 parts of dry deer treasures, 25~35 parts of dry bitter dish, 15~25 parts of dry hawthorn, 15~20 parts of dry Chinese yams
60~80 mesh of sieving is crushed to after mixing；Obtain mixed powder；
Described part is parts by weight；
4) it, by mixed powder after sterilization, recycles capsule to carry out sterile filling, sealing, obtains stomach strengthening and digestion promoting capsule.
Remarks explanation：Above-mentioned steps 4) belong to routine techniques.
The improvement of the preparation method of stomach strengthening and digestion promoting capsule as the present invention：
The vacuum drying vacuum degree of the step 2) is 0.1mbar, and drying temperature is 10~15 DEG C.
The sterilization of the step 4) is：1~1.2h of ultraviolet disinfection under 15~20 DEG C of low temperature environments.
In the present invention, hawthorn and Chinese yam choose being preferred for full maturation.
The present invention actual use method and dosage be：Oral, dosage is：Take 2 times daily, every time 15~25mg/kg
(weight).
The present invention technical advantage be：
(1) this feature that crude drug nutritive value is high, stomach strengthening and digestion promoting effect is apparent of deer treasure is made full use of, reality is conducive to
The comprehensive utilization of existing deer treasure and the exploitation of high-end stomach strengthening and digestion promoting health medicine；
(2) it considers that deer treasure is expensive, therefore it is compounded, phase using remaining (bitter dish, hawthorn, Chinese yam)
Play the role of collaboration between mutually to promote, the cost of product can be substantially reduced under the premise of keeping deer treasure using effect substantially.
(3) formula is reasonable, is free of any chemicals, and technological operation is simple, it can be achieved that industrialization continuous production.
The stomach strengthening and digestion promoting capsule of the present invention is shown through human feeding trial result：Can improve digestive function, improve appetite and
Food-intake.Illustrate that this capsule has effects that food digesting stomach fortifying.
Specific implementation mode
Embodiment 1, a kind of preparation method of stomach strengthening and digestion promoting capsule, carry out following steps successively：
1), the screening and pretreatment of raw material：
Bitter dish select fresh leaf, and cleaned, chopping (length≤0.2cm), bitter dish after must pre-processing；
Hawthorn is through peeling, cleaning, chopping (grain size≤0.2cm), hawthorn after must pre-processing；
Chinese yam is through peeling, cleaning, chopping (grain size≤0.2cm), Chinese yam after must pre-processing；
Deer treasure is fresh or freezing deer treasure；
2), Chinese yam after hawthorn, pretreatment after bitter dish, pretreatment after deer treasure, pretreatment is dried in vacuo to (vacuum degree is respectively
0.1mbar, drying temperature are 10~15 DEG C) to moisture weight content be 5~6%；To which deer treasure, dry hardship must be dried respectively
Dish, dry hawthorn, dry Chinese yam；
3), dispensing：
It is crushed to sieving after 45 parts of dry deer treasures, 25 parts of dry bitter dish, 15 parts of dry hawthorn, 15 parts of dry Chinese yams are mixed
60~80 mesh；Obtain mixed powder；
Every part is 1g；
4), by mixed powder after sterilization (the ultraviolet disinfection 1h under 15~20 DEG C of low temperature environments), recycle capsule into
Row sterile filling (that is, the mixed powder after sterilization is filled in gelatine capsule with bottle placer), sealing, obtain stomach strengthening and digestion promoting glue
Capsule.
Embodiment 2 makes the dispensing of step 3) into：50 parts of dry deer treasures, 30 parts of dry bitter dish, 20 parts of dry hawthorn, 18
The dry Chinese yam of part；Remaining is equal to embodiment 1.
Embodiment 3 makes the dispensing of step 3) into：55 parts of dry deer treasures, 35 parts of dry bitter dish, 25 parts of dry hawthorn, 20
The dry Chinese yam of part；Remaining is equal to embodiment 1.
Experiment 1, foundation《Health food is examined and assessment technique specification》(2003 editions) progress zooperies：
Healthy Kunming kind female mice totally 100 is selected, is divided into 10 groups, every group 10, carries out intestinal motility experiment,
Wistar Healthy females rat 100 is divided into 10 groups, every group 10, carries out the measurement of digestive ferment.
If three dosage groups (basic, normal, high three dosage respectively based on deer treasure 0.08,0.17,0.5g/kg) and a moon
Property distilled water control group, continuous 30 days.Experimental result such as the following table 1, table 2.
Influence of 1 tested material of table to mouse ink progradation
| Group | Number of animals/only | Total small intestinal length/cm | Prepared Chinese ink promotes length/cm | Ink progradation/% |
| Negative control group | 10 | 46.3±2.0 | 35.9±4.8 | 77.8±6.8 |
| Model control group | 10 | 46.5±1.9 | 19.9±3.7 | 44.6±9.7 |
| 1 low dose group of embodiment | 10 | 48.7±1.7 | 20.0±4.4 | 42.8±7.1 |
| 1 middle dose group of embodiment | 10 | 48.2±0.9 | 24.6±4.9 | 52.5±8.5 |
| 1 high dose group of embodiment | 10 | 47.9±3.2 | 30.8±3.9 | 64.7±4.5 |
| 2 low dose group of embodiment | 10 | 47.2±2.9 | 22.7±5.3 | 48.9±10.1 |
| 2 middle dose group of embodiment | 10 | 47.6±3.9 | 26.2±3.8 | 56.8±13.2 |
| 2 high dose group of embodiment | 10 | 46.9±1.5 | 27.2±5.7 | 59.7±4.1 |
| 3 low dose group of embodiment | 10 | 48.3±3.4 | 29.5±5.9 | 60.4±8.7 |
| 3 middle dose group of embodiment | 10 | 47.4±2.5 | 29.9±2.2 | 62.6±7.2 |
| 3 high dose group of embodiment | 10 | 47.2±3.8 | 27.4±4.1 | 58.7±9.6 |
Ink progradation passes through X=sin-1P1/2Data conversion is carried out, transformed data fit homogeneity of variance requires (P>
0.05), compared with negative control group, ink progradation is substantially reduced model control group, and difference is statistically significant, and (q is examined, P<
0.05), illustrate that mouse small intestine is wriggled and inhibit model modeling success；The high dose group of embodiment 1, the high dose group of embodiment 2 and
Compared with model control group, ink progradation obviously increases the middle dose group of embodiment 3, and difference is statistically significant, and (q is examined, P
<0.05)。
Influence of 2 tested material of table to rat stomach liquid measure, pepsin activity unit and pepsin discharge rate
Initial data meets homogeneity of variance and requires (P>0.05), compared with negative control group, 1 high dose group stomach egg of embodiment
White enzyme discharge rate dramatically increases, and the high dose group pepsin discharge rate of embodiment 2 is significantly higher than negative control group, embodiment 3
Middle dose group and high dose group pepsin discharge rate compared with negative control group have significant difference.
Following change is made to the dispensing in embodiment 3, to obtain corresponding each comparative example.
" hawthorn " is made into 45 parts by comparative example 1-1, the use for cancelling " 20 parts of Chinese yam " by 25 parts accordingly, remaining is equivalent
In embodiment 1.
" Chinese yam " is made into 45 parts by comparative example 1-2, the use for cancelling " 25 parts of hawthorn " by 20 parts accordingly, remaining is equivalent
In embodiment 1.
Comparative example 1-3, " 25 parts of hawthorn, 20 parts of Chinese yam " is made to " 35 parts of hawthorn, 10 parts of Chinese yam " into, remaining is equal to implementation
Example 1.
Comparative example 1-4, " 25 parts of hawthorn, 20 parts of Chinese yam " is made to " 15 parts of hawthorn, 30 parts of Chinese yam " into, remaining is equal to implementation
Example 1.
Comparative example 1-5, " Chinese yam " is made into " konjaku ", dosage is constant, remaining is equal to embodiment 1.
" bitter dish " are made into 80 parts by comparative example 2, the use for cancelling " 25 parts of hawthorn, 20 parts of Chinese yam " by 35 parts accordingly,
Remaining same embodiment 1.
Above-mentioned all comparative examples are detected according to above-mentioned experiment the method and (only carry out middle dose group), middle dosage
The result of pepsin discharge rate is as shown in table 3 below when group.
Influence of the tested material to rat pepsin discharge rate obtained by table 3, each comparative example
| Group | Pepsin discharge rate (U/h) |
| Comparative example 1-1 | 1095.4±102.3 |
| Comparative example 1-2 | 1100.4±123.2 |
| Comparative example 1-3 | 1120.4±121.5 |
| Comparative example 1-4 | 1140.4±125.7 |
| Comparative example 1-5 | 1135.7±153.0 |
| Comparative example 2 | 1088±134.7 |
Finally, it should also be noted that it is listed above be only the present invention several specific embodiments.Obviously, this hair
Bright to be not limited to above example, acceptable there are many deformations.Those skilled in the art can be from present disclosure
All deformations for directly exporting or associating, are considered as protection scope of the present invention.
Claims (3)
1. a kind of preparation method of stomach strengthening and digestion promoting capsule, it is characterized in that including the following steps：
1）, raw material screening and pretreatment：
Bitter dish select fresh leaf, and cleaned, chopping, bitter dish after must pre-processing；
Hawthorn is through peeling, cleaning, chopping, hawthorn after must pre-processing；
Chinese yam is through peeling, cleaning, chopping, Chinese yam after must pre-processing；
Deer treasure is fresh or freezing deer treasure；
2）, Chinese yam after hawthorn, pretreatment after bitter dish, pretreatment after deer treasure, pretreatment be dried under vacuum to moisture weight respectively contain
Amount is 5 ~ 8%；To which deer treasure, dry bitter dish, dry hawthorn, dry Chinese yam must be dried respectively；
3）, dispensing：
Powder after 45 ~ 55 parts of dry deer treasures, 25 ~ 35 parts of dry bitter dish, 15 ~ 25 parts of dry hawthorn, 15 ~ 20 parts of dry Chinese yams are mixed
It is broken to 60 ~ 80 mesh of sieving；Obtain mixed powder；
Described part is parts by weight；
4）, by mixed powder after sterilization, recycle capsule carry out sterile filling, sealing, obtain stomach strengthening and digestion promoting capsule.
2. the preparation method of stomach strengthening and digestion promoting capsule according to claim 1, it is characterized in that：
The step 2）Vacuum drying vacuum degree be 0.1mbar, drying temperature be 10 ~ 15 DEG C；
The step 4）Sterilization be：1 ~ 1.2h of ultraviolet disinfection under 15 ~ 20 DEG C of low temperature environments.
3. the preparation method of stomach strengthening and digestion promoting capsule according to claim 1 or 2, it is characterized in that：
The step 3）Dispensing be：55 parts of dry deer treasures, 35 parts of dry bitter dish, 25 parts of dry hawthorn and 20 parts of dry Chinese yams.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706401A (en) * | 2004-06-11 | 2005-12-14 | 中国科学院上海生命科学研究院 | Medicine composition containing stomach inclusion of sucking river deer and its prepn process |
| CN1706400A (en) * | 2004-06-11 | 2005-12-14 | 中国科学院上海生命科学研究院 | Application of stomach inclusion of sucking river deer in preparing medicine |
| CN1706402A (en) * | 2004-06-11 | 2005-12-14 | 中国科学院上海生命科学研究院 | Health food composition containing stomach inclusion of sucking river deer and its prepn process |
| CN102524876A (en) * | 2012-03-13 | 2012-07-04 | 河南工业大学 | Granular yam and hawthorn composite drink |
| CN102948577A (en) * | 2011-08-22 | 2013-03-06 | 天津尖峰弗兰德医药科技发展有限公司 | Chewing gum having spleen invigorating and food digesting effects, and its preparation method |
-
2015
- 2015-07-02 CN CN201510396831.XA patent/CN105012627B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706401A (en) * | 2004-06-11 | 2005-12-14 | 中国科学院上海生命科学研究院 | Medicine composition containing stomach inclusion of sucking river deer and its prepn process |
| CN1706400A (en) * | 2004-06-11 | 2005-12-14 | 中国科学院上海生命科学研究院 | Application of stomach inclusion of sucking river deer in preparing medicine |
| CN1706402A (en) * | 2004-06-11 | 2005-12-14 | 中国科学院上海生命科学研究院 | Health food composition containing stomach inclusion of sucking river deer and its prepn process |
| CN102948577A (en) * | 2011-08-22 | 2013-03-06 | 天津尖峰弗兰德医药科技发展有限公司 | Chewing gum having spleen invigorating and food digesting effects, and its preparation method |
| CN102524876A (en) * | 2012-03-13 | 2012-07-04 | 河南工业大学 | Granular yam and hawthorn composite drink |
Non-Patent Citations (5)
| Title |
|---|
| 止泻散治疗小儿泄泻;班文厚;《中医药学刊》;19871227(第06期);第4页 * |
| 獐宝治疗小儿厌食症60例临床观察;黄对忠等;《药学实践杂志》;20000420;第18卷(第2期);第68-69页 * |
| 疳积的饮食疗法;古南;《药膳食疗》;20051228(第12期);第34页 * |
| 红艳悦目甜酸果;阮杏春;《陕西中医》;19850505(第05期);第202页 * |
| 苦菜的人工驯化栽培及保健功能;郑积荣等;《中国种业》;20060815(第8期);第37页 * |
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