CN105012571A - Drug for treating demyelinating polyneuropathy and preparation method of drug - Google Patents
Drug for treating demyelinating polyneuropathy and preparation method of drug Download PDFInfo
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- CN105012571A CN105012571A CN201510554606.4A CN201510554606A CN105012571A CN 105012571 A CN105012571 A CN 105012571A CN 201510554606 A CN201510554606 A CN 201510554606A CN 105012571 A CN105012571 A CN 105012571A
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Abstract
A drug for treating demyelinating polyneuropathy is prepared from components in parts by weight as follows: 9-14 parts of oryzanol, 6-11 parts of clematis root, 5-10 parts of white peony root, 6-12 parts of Szechuan lovage rhizome, 4-11 parts of loofah sponge, 5-10 parts of common curculigo rhizome, 6-9 parts of pitaya flower, 5-8 parts of claoxylon indicumHassk, 5-11 parts of acmella oleracea, 6-12 parts of radix rubiae, 5-10 parts of phellodendron amurense, 5-10 parts of red cluster pepper, 6-11 parts of melodinus suaveolens, 5-12 parts of cynomorium songaricum, 5-10 parts of boxthorn root, 6-11 parts of eucommia bark, 5-10 parts of cortex magnoliae officinalis, 4-8 parts of caper euphorbia seeds and 5-9 parts of solidago. The drug has a very good treatment effect on acute inflammatory demyelinating polyneuropathy.
Description
Technical field
The present invention relates to a kind of medicine of Demyelinating Polyneuropathy.
Background technology
Guillain Barre syndrome, major lesions is nerve root peripheral nerve struvite demyelination widely, sometimes also involves spinal meninges, spinal cord and brain, Clinical symptoms disappears to develop the unable companion's tendon reflex of extremity symmetry rapidly.There is oblongata and paralysis of respiratory muscle and threat to life in the person of being in a bad way.Primary disease is mainly in person between twenty and fifty and child, and male is slightly many, and Summer and winter is slightly many.The patient of about 2/3 has upper respiratory tract or digestive tract infection history in premorbid a few days to several weeks.At present, treat this disease and generally adopt mode, the Western medicine oral way such as plasma exchange, immunoglobulin intravenous drip, aforesaid way therapeutic process patient bears considerable distress, and side effect is comparatively large, even there will be the symptoms such as heart failure, there is certain risk.
Summary of the invention
The object of this invention is to provide a kind of medicine of Demyelinating Polyneuropathy, it adopts raw material of Chinese medicine to add Western medicine powder composition, and therapeutic effect is remarkable.Manufacture method is simple.
Described object is achieved by the following scheme:
Medicine of a kind of Demyelinating Polyneuropathy and preparation method thereof, be prepared from by following ratio of weight and number, oryzanol 9-14 part, Radix Clematidis 6-11 part, Radix Paeoniae Alba 5-10 part, Rhizoma Chuanxiong 6-12 part, Retinervus Luffae Fructus 4-11 part, Rhizoma Curculiginis 5-10 part, overlord spend 6-9 part, Ramulus et Folium Claoxyli 5-8 part, golden button head 5-11 part, red Radix Rubiae 6-12 part, Cortex Phellodendri 5-10 part, Fructus Capsici 5-10 part, Fructus Melodini Suaveolentis 6-11 part, Herba Cynomorii 5-12 part, boxthorn root 5-10 part, Cortex Eucommiae 6-11 part, Cortex Magnoliae Officinalis 5-10 part, Semen Euphorbiae 4-8 part, Herba Solidaginis 5-9 part.
Preferred version 1:
Be prepared from by following ratio of weight and number, oryzanol 9 parts, Radix Clematidis 11 parts, the Radix Paeoniae Alba 8 parts, Rhizoma Chuanxiong 12 parts, Retinervus Luffae Fructus 4 parts, Rhizoma Curculiginis 7 parts, overlord spend 7 parts, Ramulus et Folium Claoxyli 8 parts, 5 parts, golden button head, 6 parts, red Radix Rubiae, Cortex Phellodendri 10 parts, Fructus Capsici 5 parts, Fructus Melodini Suaveolentis 9 parts, Herba Cynomorii 9 parts, boxthorn root 10 parts, the Cortex Eucommiae 11 parts, Cortex Magnoliae Officinalis 5 parts, Semen Euphorbiae 6 parts, Herba Solidaginis 7 parts.
Preferred version 2:
Be prepared from by following ratio of weight and number, oryzanol 11 parts, Radix Clematidis 8 parts, the Radix Paeoniae Alba 5 parts, Rhizoma Chuanxiong 6 parts, Retinervus Luffae Fructus 7 parts, Rhizoma Curculiginis 5 parts, overlord spend 9 parts, Ramulus et Folium Claoxyli 5 parts, 8 parts, golden button head, 10 parts, red Radix Rubiae, Cortex Phellodendri 7 parts, Fructus Capsici 10 parts, Fructus Melodini Suaveolentis 11 parts, Herba Cynomorii 5 parts, boxthorn root 8 parts, the Cortex Eucommiae 6 parts, Cortex Magnoliae Officinalis 7 parts, Semen Euphorbiae 8 parts, Herba Solidaginis 5 parts.
Preferred version 3:
Be prepared from by following ratio of weight and number, oryzanol 14 parts, Radix Clematidis 6 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Chuanxiong 9 parts, Retinervus Luffae Fructus 11 parts, Rhizoma Curculiginis 10 parts, overlord spend 6 parts, Ramulus et Folium Claoxyli 6 parts, 11 parts, golden button head, 12 parts, red Radix Rubiae, Cortex Phellodendri 5 parts, Fructus Capsici 8 parts, Fructus Melodini Suaveolentis 6 parts, Herba Cynomorii 12 parts, boxthorn root 5 parts, the Cortex Eucommiae 9 parts, Cortex Magnoliae Officinalis 10 parts, Semen Euphorbiae 4 parts, Herba Solidaginis 9 parts.
Preparation method: be prepared from by following steps,
(1) by above-mentioned raw material of Chinese medicine, removing impurity, dries, grinds powdered, mix homogeneously; (2) seal in the bucket above-mentioned raw material of Chinese medicine being placed on silvery, deposit 10 days, taking-up kraft paper is wrapped, then dries in the shade 2 days; (3) by oryzanol and described Chinese medicinal powder uniform stirring, incapsulate.
Each raw material function
Oryzanol, mainly improves autonomic nervous dysfunction, improves incretion balance obstacle and spiritual nervous disorder, therefore has certain regulating action to neurasthenia patient; Energy stabilizing the emotions, anxiety reduction and tense situation simultaneously, and improving water flood; Also be usually used in the auxiliary treatment of premenstrual tension syndrome, climacteric syndrome.
Each Chinese medicine function:
Radix Clematidis: there is expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, effect of the loose hypochondriac lump.
The Radix Paeoniae Alba: have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives effect of antiperspirant.
Rhizoma Chuanxiong: there is blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Effect of wind-expelling pain-stopping.
Retinervus Luffae Fructus, function: heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, inducing diuresis to remove edema.
Rhizoma Curculiginis, function: kidney-replenishing, bone and muscle strengthening, cold expelling wets.
Overlord spends, function: clearing away lung-heat, cough-relieving are coughed.
Ramulus et Folium Claoxyli, function: dispel the wind, dry, subside a swelling, dissipating blood stasis.
Gold button head, function: dissipating blood stasis, detumescence, pain relieving.
Red Radix Rubiae, function: removing heat from blood, hemostasis, blood stasis removing blood, to invigorate blood circulation.
Cortex Phellodendri, function: rush down kidney fire, clearing away damp-heat, separates sore.
Fructus Capsici, function: expelling wind and cold, appetizing disappears stagnant, alleviating pain and detumescence.
Fructus Melodini Suaveolentis, function: activating QI, pain relieving.
Herba Cynomorii, function: kidney invigorating and YANG supporting controlling nocturnal emission with astringent drugs, intestine moistening, strong waist knee joint.
Boxthorn root, function: clear bone fire, to bring down a fever.
The Cortex Eucommiae, function: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Cortex Magnoliae Officinalis, function: warming the middle warmer and descending qi, drying dampness to eliminate phlegm, relievings asthma.
Semen Euphorbiae, function: removing water retention by purgation is subsided a swelling, and removing blood stasis stimulates the menstrual flow.
Herba Solidaginis, dispelling wind and heat pathogens, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, has antibiosis and antiviral functions.
The present invention adopts above formula, is in harmonious proportion at oryzanol, under the mutual and synergism between each medicine, has blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, soothing the liver eliminating stagnation, nourishing the liver and kidney, promoting flow of QI and blood, replenishing QI to invigorate the spleen, effect of bringing down a fever of detoxifying.
Detailed description of the invention
Elaborate the preferred embodiment of the present invention below.
Being incapsulated by 0.5 gram by powder, take medicine every day 3 times, each 4,10 days is a course for the treatment of.
embodiment 1:
Medicine of a kind of Demyelinating Polyneuropathy and preparation method thereof, be prepared from by following ratio of weight and number, oryzanol 9-14 part, Radix Clematidis 6-11 part, Radix Paeoniae Alba 5-10 part, Rhizoma Chuanxiong 6-12 part, Retinervus Luffae Fructus 4-11 part, Rhizoma Curculiginis 5-10 part, overlord spend 6-9 part, Ramulus et Folium Claoxyli 5-8 part, golden button head 5-11 part, red Radix Rubiae 6-12 part, Cortex Phellodendri 5-10 part, Fructus Capsici 5-10 part, Fructus Melodini Suaveolentis 6-11 part, Herba Cynomorii 5-12 part, boxthorn root 5-10 part, Cortex Eucommiae 6-11 part, Cortex Magnoliae Officinalis 5-10 part, Semen Euphorbiae 4-8 part, Herba Solidaginis 5-9 part.Preparation method is shown in embodiment 2.
model case:
Lee, female, 36 years old, patient gave an oral account extremity acid Chen Wuli, and between two weeks, paralysis appears in lower limb gradually, numbness of the skin is micro-swollen, and heavy sensation of the whole body is stagnant, and fever of the body is not smooth, uncomfortable in chest, loose stool, urine swelling pain, red tongue yellow and greasy fur, is diagnosed as Guillain Barre syndrome.After giving a course for the treatment of of capsule for treating of the present invention, symptom is obviously improved, and after two courses for the treatment of, symptom disappears completely.Follow up a case by regular visits to 1 year without recurrence.
embodiment 2:
Be prepared from by following ratio of weight and number, oryzanol 9 parts, Radix Clematidis 11 parts, the Radix Paeoniae Alba 8 parts, Rhizoma Chuanxiong 12 parts, Retinervus Luffae Fructus 4 parts, Rhizoma Curculiginis 7 parts, overlord spend 7 parts, Ramulus et Folium Claoxyli 8 parts, 5 parts, golden button head, 6 parts, red Radix Rubiae, Cortex Phellodendri 10 parts, Fructus Capsici 5 parts, Fructus Melodini Suaveolentis 9 parts, Herba Cynomorii 9 parts, boxthorn root 10 parts, the Cortex Eucommiae 11 parts, Cortex Magnoliae Officinalis 5 parts, Semen Euphorbiae 6 parts, Herba Solidaginis 7 parts.
Preparation method: be prepared from by following steps,
(1) by above-mentioned raw material of Chinese medicine, removing impurity, dries, grinds powdered, mix homogeneously; (2) seal in the bucket above-mentioned raw material of Chinese medicine being placed on silvery, deposit 10 days, taking-up kraft paper is wrapped, then dries in the shade 2 days; (3) by oryzanol and described Chinese medicinal powder uniform stirring, incapsulate.
model case:
Chen, man, 38 years old, have intestinal infection symptom before patient's readme onset, after two weeks, the symmetrical unable companion's paraesthesia of extremity, expands from lower limb to upper limb, rear paralysis, lab testing discovery spinal fluid protein content is high and cell number normal, is diagnosed as Guillain Barre syndrome; After the course for the treatment of of oral capsule for treating of the present invention, symptom is obviously improved, and after three courses for the treatment of, symptom disappears completely; Check that all are normal; Follow up a case by regular visits to 1 year without recurrence.
embodiment 3:
Be prepared from by following ratio of weight and number, oryzanol 11 parts, Radix Clematidis 8 parts, the Radix Paeoniae Alba 5 parts, Rhizoma Chuanxiong 6 parts, Retinervus Luffae Fructus 7 parts, Rhizoma Curculiginis 5 parts, overlord spend 9 parts, Ramulus et Folium Claoxyli 5 parts, 8 parts, golden button head, 10 parts, red Radix Rubiae, Cortex Phellodendri 7 parts, Fructus Capsici 10 parts, Fructus Melodini Suaveolentis 11 parts, Herba Cynomorii 5 parts, boxthorn root 8 parts, the Cortex Eucommiae 6 parts, Cortex Magnoliae Officinalis 7 parts, Semen Euphorbiae 8 parts, Herba Solidaginis 5 parts.Preparation method is identical with embodiment 2.
model case:
Pan, man, 34 years old, patient's condition was more slow, and in three weeks, extremity flaccidity is soft gradually, soreness of the waist and knees, wasting and atrophy of muscle, with dizziness and tinnitus, the few tongue of red tongue, rapid pulse is thin, is diagnosed as Guillain Barre syndrome; After the course for the treatment of of oral capsule for treating of the present invention, symptom is improved, and after three courses for the treatment of, symptom disappears completely, follows up a case by regular visits to 1 year without recurrence.
embodiment 4:
Be prepared from by following ratio of weight and number, oryzanol 14 parts, Radix Clematidis 6 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Chuanxiong 9 parts, Retinervus Luffae Fructus 11 parts, Rhizoma Curculiginis 10 parts, overlord spend 6 parts, Ramulus et Folium Claoxyli 6 parts, 11 parts, golden button head, 12 parts, red Radix Rubiae, Cortex Phellodendri 5 parts, Fructus Capsici 8 parts, Fructus Melodini Suaveolentis 6 parts, Herba Cynomorii 12 parts, boxthorn root 5 parts, the Cortex Eucommiae 9 parts, Cortex Magnoliae Officinalis 10 parts, Semen Euphorbiae 4 parts, Herba Solidaginis 9 parts.Preparation method is identical with embodiment 2.
136 routine patients take, the oldest is 48 years old, minimum is 15 years old, after taking medicine one, effective person is 100%, extremity after a course for the treatment of of taking medicine are felt, can activist are slowly 68%, the symptom of paralysing after two courses for the treatment of of taking medicine alleviates, and breathing steady person is 88%, and after three courses for the treatment of of taking medicine, transference cure, breathing, normotensive are 98%.Symptom after four courses for the treatment of of taking medicine can all disappear.
Visible, medicine of the present invention is fine to treatment Guillain Barre syndrome effect.
Present embodiment does not just limit its protection domain to the exemplary illustration of this patent; those skilled in the art can also carry out local to it and change; as long as no the spirit exceeding this patent, be all considered as the equivalent replacement to this patent, all within the protection domain of this patent.
Claims (5)
1. a medicine for Guillain Barre syndrome, is characterized in that: be prepared from by following ratio of weight and number, oryzanol 9-14 part, Radix Clematidis 6-11 part, Radix Paeoniae Alba 5-10 part, Rhizoma Chuanxiong 6-12 part,
Retinervus Luffae Fructus 4-11 part, Rhizoma Curculiginis 5-10 part, overlord spend 6-9 part, Ramulus et Folium Claoxyli 5-8 part, golden button head 5-11 part, red Radix Rubiae 6-12 part, Cortex Phellodendri 5-10 part, Fructus Capsici 5-10 part, Fructus Melodini Suaveolentis 6-11 part, Herba Cynomorii 5-12 part, boxthorn root 5-10 part, Cortex Eucommiae 6-11 part, Cortex Magnoliae Officinalis 5-10 part, Semen Euphorbiae 4-8 part, Herba Solidaginis 5-9 part.
2. the medicine of a kind of Guillain Barre syndrome according to claim 1, it is characterized in that: be prepared from by following ratio of weight and number, oryzanol 9 parts, Radix Clematidis 11 parts, the Radix Paeoniae Alba 8 parts, Rhizoma Chuanxiong 12 parts, Retinervus Luffae Fructus 4 parts, Rhizoma Curculiginis 7 parts, overlord spend 7 parts, Ramulus et Folium Claoxyli 8 parts, 5 parts, golden button head, 6 parts, red Radix Rubiae, Cortex Phellodendri 10 parts, Fructus Capsici 5 parts, Fructus Melodini Suaveolentis 9 parts, Herba Cynomorii 9 parts, boxthorn root 10 parts, the Cortex Eucommiae 11 parts, Cortex Magnoliae Officinalis 5 parts, Semen Euphorbiae 6 parts, Herba Solidaginis 7 parts.
3. the medicine of a kind of Guillain Barre syndrome according to claim 1, it is characterized in that: be prepared from by following ratio of weight and number, oryzanol 11 parts, Radix Clematidis 8 parts, the Radix Paeoniae Alba 5 parts, Rhizoma Chuanxiong 6 parts, Retinervus Luffae Fructus 7 parts, Rhizoma Curculiginis 5 parts, overlord spend 9 parts, Ramulus et Folium Claoxyli 5 parts, 8 parts, golden button head, 10 parts, red Radix Rubiae, Cortex Phellodendri 7 parts, Fructus Capsici 10 parts, Fructus Melodini Suaveolentis 11 parts, Herba Cynomorii 5 parts, boxthorn root 8 parts, the Cortex Eucommiae 6 parts, Cortex Magnoliae Officinalis 7 parts, Semen Euphorbiae 8 parts, Herba Solidaginis 5 parts.
4. the medicine of a kind of Guillain Barre syndrome according to claim 1, it is characterized in that: be prepared from by following ratio of weight and number, oryzanol 14 parts, Radix Clematidis 6 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Chuanxiong 9 parts, Retinervus Luffae Fructus 11 parts, Rhizoma Curculiginis 10 parts, overlord spend 6 parts, Ramulus et Folium Claoxyli 6 parts, 11 parts, golden button head, 12 parts, red Radix Rubiae, Cortex Phellodendri 5 parts, Fructus Capsici 8 parts, Fructus Melodini Suaveolentis 6 parts, Herba Cynomorii 12 parts, boxthorn root 5 parts, the Cortex Eucommiae 9 parts, Piao 10 parts, Semen Euphorbiae 4 parts, Herba Solidaginis 9 parts.
5. the process for preparing medicine of a kind of Guillain Barre syndrome described in claim 1-4, is characterized in that: be prepared from by following steps, (1) is by above-mentioned raw material of Chinese medicine, removing impurity, dry, grind powdered, mix homogeneously; (2) seal in the bucket above-mentioned raw material of Chinese medicine being placed on silvery, deposit 10 days, taking-up kraft paper is wrapped, then dries in the shade 2 days; (3) by oryzanol and described Chinese medicinal powder uniform stirring, incapsulate.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168572A (en) * | 2015-09-03 | 2015-12-23 | 哈尔滨泉兴科技有限公司 | Medicine for fast treating inflammatory demyelinating polyneuropathy |
| CN105435055A (en) * | 2015-12-26 | 2016-03-30 | 哈尔滨和谐旺科技开发有限公司 | Traditional Chinese medicine for efficiently treating polyneuropathy |
| CN106237125A (en) * | 2016-09-30 | 2016-12-21 | 李先强 | The active medicine of wind for Demyelination |
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| CN104288388A (en) * | 2014-10-27 | 2015-01-21 | 哈尔滨金玉科技开发有限公司 | Medicament for treating acute inflammatory demyelinating polyneuropathies and preparation method of medicament |
| CN105012833A (en) * | 2015-08-15 | 2015-11-04 | 哈尔滨和谐旺科技开发有限公司 | Traditional Chinese medicine for treating polyneuropathy |
| CN105168572A (en) * | 2015-09-03 | 2015-12-23 | 哈尔滨泉兴科技有限公司 | Medicine for fast treating inflammatory demyelinating polyneuropathy |
| CN105435055A (en) * | 2015-12-26 | 2016-03-30 | 哈尔滨和谐旺科技开发有限公司 | Traditional Chinese medicine for efficiently treating polyneuropathy |
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2015
- 2015-09-03 CN CN201510554606.4A patent/CN105012571A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104288388A (en) * | 2014-10-27 | 2015-01-21 | 哈尔滨金玉科技开发有限公司 | Medicament for treating acute inflammatory demyelinating polyneuropathies and preparation method of medicament |
| CN105012833A (en) * | 2015-08-15 | 2015-11-04 | 哈尔滨和谐旺科技开发有限公司 | Traditional Chinese medicine for treating polyneuropathy |
| CN105168572A (en) * | 2015-09-03 | 2015-12-23 | 哈尔滨泉兴科技有限公司 | Medicine for fast treating inflammatory demyelinating polyneuropathy |
| CN105435055A (en) * | 2015-12-26 | 2016-03-30 | 哈尔滨和谐旺科技开发有限公司 | Traditional Chinese medicine for efficiently treating polyneuropathy |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168572A (en) * | 2015-09-03 | 2015-12-23 | 哈尔滨泉兴科技有限公司 | Medicine for fast treating inflammatory demyelinating polyneuropathy |
| CN105435055A (en) * | 2015-12-26 | 2016-03-30 | 哈尔滨和谐旺科技开发有限公司 | Traditional Chinese medicine for efficiently treating polyneuropathy |
| CN106237125A (en) * | 2016-09-30 | 2016-12-21 | 李先强 | The active medicine of wind for Demyelination |
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Application publication date: 20151104 |