CN104997519B - 基于眼底相机的双波长视网膜血管血氧测量*** - Google Patents
基于眼底相机的双波长视网膜血管血氧测量*** Download PDFInfo
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- CN104997519B CN104997519B CN201510496619.0A CN201510496619A CN104997519B CN 104997519 B CN104997519 B CN 104997519B CN 201510496619 A CN201510496619 A CN 201510496619A CN 104997519 B CN104997519 B CN 104997519B
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 58
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 58
- 239000001301 oxygen Substances 0.000 title claims abstract description 58
- 239000008280 blood Substances 0.000 title claims abstract description 45
- 210000004369 blood Anatomy 0.000 title claims abstract description 45
- 210000001210 retinal vessel Anatomy 0.000 title claims abstract description 21
- 238000005259 measurement Methods 0.000 title description 4
- 230000003287 optical effect Effects 0.000 claims abstract description 35
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 28
- 230000004256 retinal image Effects 0.000 claims abstract description 28
- 230000009977 dual effect Effects 0.000 claims abstract description 25
- 238000003384 imaging method Methods 0.000 claims abstract description 21
- 210000001525 retina Anatomy 0.000 claims abstract description 15
- 238000000605 extraction Methods 0.000 claims abstract description 7
- 102000001554 Hemoglobins Human genes 0.000 claims description 28
- 108010054147 Hemoglobins Proteins 0.000 claims description 28
- 238000010521 absorption reaction Methods 0.000 claims description 12
- 238000002496 oximetry Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 6
- 238000013519 translation Methods 0.000 claims description 5
- 230000011218 segmentation Effects 0.000 claims description 4
- 238000000862 absorption spectrum Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 claims description 2
- 230000004075 alteration Effects 0.000 claims description 2
- 230000006870 function Effects 0.000 claims description 2
- 230000013011 mating Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 210000003733 optic disk Anatomy 0.000 claims description 2
- 230000009466 transformation Effects 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims 3
- 230000000877 morphologic effect Effects 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 238000011160 research Methods 0.000 abstract description 3
- 238000003745 diagnosis Methods 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 description 4
- 230000002207 retinal effect Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000004424 eye movement Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
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- 238000001514 detection method Methods 0.000 description 1
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- 238000013399 early diagnosis Methods 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000004220 fundus oculi Anatomy 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000003709 image segmentation Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14555—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for the eye fundus
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Optics & Photonics (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Ophthalmology & Optometry (AREA)
- Eye Examination Apparatus (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
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CN201510496619.0A CN104997519B (zh) | 2015-08-13 | 2015-08-13 | 基于眼底相机的双波长视网膜血管血氧测量*** |
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CN201510496619.0A CN104997519B (zh) | 2015-08-13 | 2015-08-13 | 基于眼底相机的双波长视网膜血管血氧测量*** |
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CN104997519A CN104997519A (zh) | 2015-10-28 |
CN104997519B true CN104997519B (zh) | 2018-09-18 |
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CN201510496619.0A Active CN104997519B (zh) | 2015-08-13 | 2015-08-13 | 基于眼底相机的双波长视网膜血管血氧测量*** |
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Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106442406A (zh) * | 2016-11-25 | 2017-02-22 | 佛山科学技术学院 | 一种基于双波长激光的血氧饱和度检测装置及方法 |
CN108267832A (zh) * | 2016-12-30 | 2018-07-10 | 中国空气动力研究与发展中心超高速空气动力研究所 | 一种单相机双波长分幅成像镜头 |
CN107550454A (zh) * | 2017-10-19 | 2018-01-09 | 南京泰明生物科技有限公司 | 一种多模态眼底成像*** |
CN109791694B (zh) | 2018-12-05 | 2023-06-30 | 京东方科技集团股份有限公司 | 用于确定对象的生理参数的方法和设备及其计算机程序产品 |
CN109431455A (zh) * | 2018-12-21 | 2019-03-08 | 合肥奥比斯科技有限公司 | 双模态眼底成像*** |
CN110432861A (zh) * | 2019-08-12 | 2019-11-12 | 北京大学 | 一种动态光刺激视网膜血氧饱和度测量***及其测量方法 |
CN110448267B (zh) * | 2019-09-06 | 2021-05-25 | 重庆贝奥新视野医疗设备有限公司 | 一种多模眼底动态成像分析***及其方法 |
CN112386813B (zh) * | 2020-10-29 | 2022-11-04 | 苏州君信视达医疗科技有限公司 | 用于激光治疗的成像获取***、方法、设备及存储介质 |
CN116327111B (zh) * | 2023-02-28 | 2024-01-16 | 中山大学中山眼科中心 | 基于眼底照片的眼底血管血氧功能系数测量***及方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1658788A (zh) * | 2002-04-02 | 2005-08-24 | 耶德研究和发展有限公司 | 固定背景中的移动物体的特征描述 |
EP2016889A1 (en) * | 2007-07-19 | 2009-01-21 | Nidek Co., Ltd. | Fundus imaging apparatus |
CN102028477A (zh) * | 2010-12-22 | 2011-04-27 | 中国科学院光电技术研究所 | 一种测量眼底视网膜血氧饱和度的装置及方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000006017A1 (en) * | 1998-07-30 | 2000-02-10 | University Of Virginia Patent Foundation | Imaging ocular vessel oximeter |
JP4776450B2 (ja) * | 2006-06-16 | 2011-09-21 | 株式会社トプコン | 眼科撮影装置 |
JPWO2014129522A1 (ja) * | 2013-02-21 | 2017-02-02 | 興和株式会社 | 眼底撮像装置および網膜組織特徴量測定方法 |
-
2015
- 2015-08-13 CN CN201510496619.0A patent/CN104997519B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1658788A (zh) * | 2002-04-02 | 2005-08-24 | 耶德研究和发展有限公司 | 固定背景中的移动物体的特征描述 |
EP2016889A1 (en) * | 2007-07-19 | 2009-01-21 | Nidek Co., Ltd. | Fundus imaging apparatus |
CN102028477A (zh) * | 2010-12-22 | 2011-04-27 | 中国科学院光电技术研究所 | 一种测量眼底视网膜血氧饱和度的装置及方法 |
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C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Dai Yun Inventor after: Xianyongli Inventor after: Du Rui Inventor after: Zhang Yudong Inventor after: Man Wengang Inventor after: Duan Junguo Inventor before: Dai Yun Inventor before: Xianyongli Inventor before: Du Rui Inventor before: Zhang Yudong |
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TA01 | Transfer of patent application right |
Effective date of registration: 20161110 Address after: 610209 Sichuan Province, Chengdu Shuangliu box 350 Applicant after: INSTITUTE OF OPTICS AND ELECTRONICS, CHINESE ACADEMY OF SCIENCES Applicant after: SICHUAN HEALTHSUN VISION MEDICAL TECHNOLOGY DEVELOPMENT CO.,LTD. Applicant after: Chengdu University of Traditional Chinese Medicine Address before: 610209 Sichuan Province, Chengdu Shuangliu box 350 Applicant before: INSTITUTE OF OPTICS AND ELECTRONICS, CHINESE ACADEMY OF SCIENCES |
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