CN104984023A - Garlic polysaccharide soft capsule - Google Patents
Garlic polysaccharide soft capsule Download PDFInfo
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- CN104984023A CN104984023A CN201510311081.1A CN201510311081A CN104984023A CN 104984023 A CN104984023 A CN 104984023A CN 201510311081 A CN201510311081 A CN 201510311081A CN 104984023 A CN104984023 A CN 104984023A
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Abstract
Provides is a garlic polysaccharide soft capsule. A preparation method of the garlic polysaccharide soft capsule includes the steps that garlic polysaccharide extracts, alliaceous rhizoma ligustici wallichii extracts, alliaceous ginseng extracts, alliaceous Chinese wolfberry extracts, alliaceous astragalus extracts and alliaceous hawthorn flavonoids extracts are taken and mixed so as to obtain a comprehensive mixture; the comprehensive mixture and ramie oil are mixed so as to obtain oily content for standby application; gelatin pearl capsule material gelatin shells made of edible gelatin are laid in equipment, the oily content is automatically injected into the gelatin pearl capsule material gelatin shells according to the dosage, particle soft capsules meeting the measurement standard are pressed and made through a mold, and then the garlic polysaccharide soft capsule is obtained; and each capsule is 1 g, and a user takes 1-2 capsules each time and takes the capsules three times a day.
Description
Technical field
What the present invention relates to is a kind of garlic polysaccharide soft capsule.
Background technology
Have document announcement, steep in wine with Bulbus Allii, the multiple complications can treated hyperlipidemia and bring out, but experiment proves that the effect that Bulbus Allii single is steep in wine does not have compound recipe effective, compound recipe is very exquisite, and does not have the bibliographical information of compound recipe.The report of the garlicin soft capsule that Zeng Jianyou abroad produces, but the application purpose of this Bulbus Allii soft capsule, mainly improve athlete's energy, and with treatment hyperlipidemia and complication thereof, as hypertension, diabetes etc., it doesn't matter.So the soft capsule of a kind of compound garlic polysaccharide of necessary research, carrying out satisfied masses needs to use.
Summary of the invention
The object of this invention is to provide a kind of garlic polysaccharide soft capsule.
The object of the present invention is achieved like this: a, select fresh purple garlic, peeling, after garlic clove being rolled into mashed garlic cake, get its making beating again, with 4 times amount water boil 20min, squeezing extracting juice, four layers of filtered through gauze, Bulbus Allii slag adds 3 times of water boils again and squeezes extracting juice filtration, and twice filtrate merges, and 3500r/min is centrifugal; Get supernatant and be concentrated into soluble solid at 60 DEG C, then go up DEAE celluosic resin post, washing, eluent 5% phenolsulfuric acid reagent detects polysaccharide, then is merged by garlic polysaccharide product, obtains garlic polysaccharide extract through lyophilization, for subsequent use; B, select fresh Rhizoma Chuanxiong, clean, stripping and slicing, mix with fresh peeling garlic clove, with the ratio of 7:3, enters in beater and pull an oar, and connects slag band slurry and places 1h, allow two tastes fully react to each other, and then extracts the garlicky Rhizoma Chuanxiong extract of acquisition with supercritical extraction process, for subsequent use; C, select fresh ginseng, clean, stripping and slicing, mix with fresh peeling garlic clove, with the ratio of 7:3, enters in beater and pull an oar, and connects slag band slurry and places 1h, allow two tastes fully react to each other, then use supercritical extraction process, extract the garlicky Radix Ginseng extract of acquisition, for subsequent use; D, select fresh fructus lycii, clean, mix with fresh peeling garlic clove, with the ratio of 7:3, enter in beater and pull an oar, connect slag band slurry and place 1h, allow two tastes fully react to each other, then, with supercritical extraction process, extract the garlicky wolfberry fruit extract of acquisition, for subsequent use; E, select cadmium yellow stilbene, edulcoration, stripping and slicing, mix with fresh peeling garlic clove, with the ratio of 7:3, enter in beater and pull an oar, connect slag band slurry and place 1h, allow two tastes fully react to each other, then use supercritical extraction process, extract and obtain garlicky Radix Astragali extract, for subsequent use; F, get fresh Fructus Crataegi leaf, clean, making beating, constantly add peeling garlic clove and mix with it and pulls an oar, with the operation sequential of 7:3, mixing slurry is placed 1h, allows two tastes fully react to each other, then use supercritical extraction process, extract and obtain garlicky hawthorn flavone extract, for subsequent use; The garlicky hawthorn flavone extract 10% of garlicky Radix Astragali extract 5-10%, f step acquisition that the garlicky wolfberry fruit extract 5-20% that the garlicky Radix Ginseng extract 5-20% that the garlicky Rhizoma Chuanxiong extract 5-20% that g, the garlic polysaccharide extract 20-70% getting the acquisition of a step, b step obtain, step c obtain, Step d obtain, step e obtain, mix, obtain synthetic mixture, for subsequent use; H, get commercial hemp oil 30%, g step obtain synthetic mixture 70%, mix, obtain oily body content, for subsequent use; I, the soft gelatin capsule capsule material rubber made of edible Gelatinum oxhide, spread in equipment, is according to dosage automatically injected the oily body content that h step obtains, is pressed into the granule soft capsule meeting measurement criteria by mould; Every 1g, each 1-2 ball, every day three times.
Good effect of the present invention is: fresh garlic is rolled into mud cake process, can make Bulbus Allii generation chemical change, produce the compositions such as a large amount of allicins, the using value of Common garlic is improved.It is cut into slices by Bulbus Allii that tradition Bulbus Allii is extracted, dry, then pulverizes extraction.It is crowded not broken through rolling, or is pounded mashed garlic, or together pulverizes making beating with garlic clove and fresh medicine, can improve biological activity.Have experience to prove, Traditional Folk is pounded garlic mud, and the health value of Bulbus Allii can be made to improve, and directly garlic clove is put into pot stew, its effect does not almost have.So, in this case, fresh garlic and fresh medicine used are together pulled an oar, just can make the direct and fresh medical material generation biological respinse of Bulbus Allii, improve bioavailability, the superiority of fully outstanding Bulbus Allii function.Then each garlicky medicine is mixed again with garlic polysaccharide, just can make high-caliber garlic health-care product.
Bulbus Allii: containing garlicin and allicin, garlic polysaccharide, and the multiple nutritional components such as organic germanium, selenium, SOD, there are sterilization, parasite killing, antiviral, antitumor, to cardiovascular disease Be very effective, decreased heart rate, enhancing myocardial contraction, expansion peripheral vessel, increases diuresis, it all can be made to reduce to hypertension and hyperlipidemia.All effective to gastric cancer, esophageal carcinoma, nasopharyngeal carcinoma, hepatocarcinoma, breast carcinoma, cervical cancer.
Rhizoma Chuanxiong: warm in nature, blood-activating and qi-promoting, wind-expelling pain-stopping, for menoxenia, dysmenorrhea, amenorrhea, difficult labour, postpartum stagnation is suffered from abdominal pain, and the rib side of body is had a pain, numb limbs and tense tendons, and traumatic injury, the cards such as sore, carbuncle and painful swelling.Forefathers are called the gas medicine in blood, effect of the sensible QI and blood of real tool.In recent years clinical conventional this product treatment coronary heart diseases and angina pectoris and ischemic cerebrovascular, also control waist foot weak, hemiplegia.
Radix Ginseng: slightly warm in nature, strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, increasing intelligence of calming the nerves, for the deficiency of vital energy for de-, the card of faint pulse being about to disappear, deficiency of spleen-QI, lassitude, inappetence, insomnia and dreamful sleep, palpitates with fear forgetful, irritability, lung qi virtual loss, Tianjin wound is thirsty, quench one's thirst, and insomnia and dreamful sleep, palpitates with fear forgetful, also can be used for the card such as blood deficiency and sexual impotence, to the empty diseases caused by exogenous pathogenic factor of body or the weakened body resistance card of interior-excess. " herbal classic ": " tonifying five ZANG-organs, peace spirit, determines soul; spasmolytic is throbbed with fear, except pathogen, improving eyesight, happy Fructus Alpiniae Oxyphyllae." tetradecapeptide containing islets of langerhans sample activity, carbohydrate metabolism is had a significant effect, to abnormal blood sugar level, there is dual regulation.Ginsenoside has suppression insulin to be fat effect by convert glucose, and ginseng polysaccharide, ginseng polypeptide, the non-Saponin part of Radix Ginseng all have blood sugar reducing function.
Fructus Lycii: sweet in the mouth, property is put down.Return liver, kidney channel.Effect: the function having nourishing the liver and kidney, replenishing vital essence to improve eyesight.For diseases such as asthenia damage of essence, Light-headedness, tinnitus, ache of the spinal column, seminal emissions.Pharmacological action: (1) enhancing non-specific immunity function: mouse gavaging lycium barbarum water extract or alcohol extract intramuscular injection, all significantly can strengthen the phagocytic activity of reticuloendothelial system to india ink.(2), hemoposieis: every day gavages Lycium Barbarum, has facilitation to the hemopoietic function of normal mouse.(3), hypoglycemic activity: the reduction that lycium barbarum extracts can cause rat blood sugar remarkable and lasting.The blood sugar reducing function of its polysaccharide and the very similar of Radix Rehmanniae.The expression of fatty tissue gene can be suppressed, improve islet beta cell function, improve disorders of lipid metabolism, thus reduce the blood glucose of test rat.
The Radix Astragali: invigorating QI to consolidate the body surface resistance, diuresis poison holding, weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea metrorrhagia, spontaneous perspiration, edema, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.This product can strengthen metabolism, improves nutrition of whole body state.Containing alpha-glucosidase inhibitor composition, its astragalus polysaccharides has more lasting obvious effect to blood sugar lowering.
Fructus Crataegi flavone: the Fructus Crataegi flavone extracted from Folium Crataegi, can make coronary artery expansion, has blood fat reducing, blood pressure lowering and cardiotonic, can improve the effect of heart vigor and stimulating central nervous system system, and tool antioxidation.Protective effect is had to the cardiac function for the treatment of myocardial ischemia damage.
Boehmeria: containing unsaturated fatty acid more than 90%, polyunsaturated fatty acid more than 79%, linoleic acid content is particularly abundant, reaches 77.4%-78.84%, also containing 17 seed amino acids.Unsaturated fatty acid is to adjusting blood lipid, and tumor prevention, Improving memory many-side plays an important role, and polyunsaturated fatty acid can reduce the M & M of cardiovascular and cerebrovascular disease, has preventive effect to diabetes complicated angiopathy.
Detailed description of the invention
Embodiment one: a, select fresh purple garlic, peeling, after garlic clove being rolled into mashed garlic cake, then get its making beating, with 4 times amount water boil 20min, squeezing extracting juice, four layers of filtered through gauze, Bulbus Allii slag adds 3 times of water boils again and squeezes extracting juice filtration, and twice filtrate merges, and 3500r/min is centrifugal; Get supernatant and be concentrated into soluble solid at 60 DEG C, then go up DEAE celluosic resin post, washing, eluent 5% phenolsulfuric acid reagent detects polysaccharide, then is merged by garlic polysaccharide product, obtains garlic polysaccharide extract through lyophilization, for subsequent use; B, select fresh Rhizoma Chuanxiong, clean, stripping and slicing, mix with fresh peeling garlic clove, with the ratio of 7:3, enters in beater and pull an oar, and connects slag band slurry and places 1h, allow two tastes fully react to each other, and then extracts the garlicky Rhizoma Chuanxiong extract of acquisition with supercritical extraction process, for subsequent use; C, select fresh ginseng, clean, stripping and slicing, mix with fresh peeling garlic clove, with the ratio of 7:3, enters in beater and pull an oar, and connects slag band slurry and places 1h, allow two tastes fully react to each other, then use supercritical extraction process, extract the garlicky Radix Ginseng extract of acquisition, for subsequent use; D, select fresh fructus lycii, clean, mix with fresh peeling garlic clove, with the ratio of 7:3, enter in beater and pull an oar, connect slag band slurry and place 1h, allow two tastes fully react to each other, then, with supercritical extraction process, extract the garlicky wolfberry fruit extract of acquisition, for subsequent use; E, select cadmium yellow stilbene, edulcoration, stripping and slicing, mix with fresh peeling garlic clove, with the ratio of 7:3, enter in beater and pull an oar, connect slag band slurry and place 1h, allow two tastes fully react to each other, then use supercritical extraction process, extract and obtain garlicky Radix Astragali extract, for subsequent use; F, get fresh Fructus Crataegi leaf, clean, making beating, constantly add peeling garlic clove and mix with it and pulls an oar, with the operation sequential of 7:3, mixing slurry is placed 1h, allows two tastes fully react to each other, then use supercritical extraction process, extract and obtain garlicky hawthorn flavone extract, for subsequent use; The garlicky hawthorn flavone extract 10% of the garlicky Radix Astragali extract 5% that the garlicky wolfberry fruit extract 5% that the garlicky Radix Ginseng extract 5% that the garlicky Rhizoma Chuanxiong extract 5-20% that g, the garlic polysaccharide extract 70% getting the acquisition of a step, b step obtain, step c obtain, Step d obtain, step e obtain, the acquisition of f step, mix, obtain synthetic mixture, for subsequent use; H, get commercial hemp oil 30%, g step obtain synthetic mixture 70%, mix, obtain oily body content, for subsequent use; I, the soft gelatin capsule capsule material rubber made of edible Gelatinum oxhide, spread in equipment, is according to dosage automatically injected the oily body content that h step obtains, is pressed into the granule soft capsule meeting measurement criteria by mould; Every 1g, each 1-2 ball, every day three times.
Embodiment two: a, select fresh purple garlic, peeling, after garlic clove being rolled into mashed garlic cake, then get its making beating, with 4 times amount water boil 20min, squeezing extracting juice, four layers of filtered through gauze, Bulbus Allii slag adds 3 times of water boils again and squeezes extracting juice filtration, and twice filtrate merges, and 3500r/min is centrifugal; Get supernatant and be concentrated into soluble solid at 60 DEG C, then go up DEAE celluosic resin post, washing, eluent 5% phenolsulfuric acid reagent detects polysaccharide, then is merged by garlic polysaccharide product, obtains garlic polysaccharide extract through lyophilization, for subsequent use; B, select fresh Rhizoma Chuanxiong, clean, stripping and slicing, mix with fresh peeling garlic clove, with the ratio of 7:3, enters in beater and pull an oar, and connects slag band slurry and places 2h, allow two tastes fully react to each other, and then extracts the garlicky Rhizoma Chuanxiong extract of acquisition with supercritical extraction process, for subsequent use; C, select fresh ginseng, clean, stripping and slicing, mix with fresh peeling garlic clove, with the ratio of 7:3, enters in beater and pull an oar, and connects slag band slurry and places 2h, allow two tastes fully react to each other, then use supercritical extraction process, extract the garlicky Radix Ginseng extract of acquisition, for subsequent use; D, select fresh fructus lycii, clean, mix with fresh peeling garlic clove, with the ratio of 7:3, enter in beater and pull an oar, connect slag band slurry and place 2h, allow two tastes fully react to each other, then, with supercritical extraction process, extract the garlicky wolfberry fruit extract of acquisition, for subsequent use; E, select cadmium yellow stilbene, edulcoration, stripping and slicing, mix with fresh peeling garlic clove, with the ratio of 7:3, enter in beater and pull an oar, connect slag band slurry and place 2h, allow two tastes fully react to each other, then use supercritical extraction process, extract and obtain garlicky Radix Astragali extract, for subsequent use; F, get fresh Fructus Crataegi leaf, clean, making beating, constantly add peeling garlic clove and mix with it and pulls an oar, with the operation sequential of 7:3, mixing slurry is placed 2h, allows two tastes fully react to each other, then use supercritical extraction process, extract and obtain garlicky hawthorn flavone extract, for subsequent use; The garlicky hawthorn flavone extract 10% of the garlicky Radix Astragali extract 10% that the garlicky wolfberry fruit extract 20% that the garlicky Radix Ginseng extract 20% that the garlicky Rhizoma Chuanxiong extract 20% that g, the garlic polysaccharide extract 20% getting the acquisition of a step, b step obtain, step c obtain, Step d obtain, step e obtain, the acquisition of f step, mix, obtain synthetic mixture, for subsequent use; H, get commercial hemp oil 30%, g step obtain synthetic mixture 70%, mix, obtain oily body content, for subsequent use; I, the soft gelatin capsule capsule material rubber made of edible Gelatinum oxhide, spread in equipment, is according to dosage automatically injected the oily body content that h step obtains, is pressed into the granule soft capsule meeting measurement criteria by mould; Every 1g, each 1-2 ball, every day three times.
Claims (1)
1. a garlic polysaccharide soft capsule, its preparation method is as follows: a, select fresh purple garlic, peeling, after garlic clove being rolled into mashed garlic cake, then gets its making beating, with 4 times amount water boil 20min, squeezing extracting juice, four layers of filtered through gauze, Bulbus Allii slag adds 3 times of water boils again and squeezes extracting juice filtration, twice filtrate merges, and 3500r/min is centrifugal; Get supernatant and be concentrated into soluble solid at 60 DEG C, then go up DEAE celluosic resin post, washing, eluent 5% phenolsulfuric acid reagent detects polysaccharide, then is merged by garlic polysaccharide product, obtains garlic polysaccharide extract through lyophilization, for subsequent use; B, select fresh Rhizoma Chuanxiong, clean, stripping and slicing, mixes with fresh peeling garlic clove, with the ratio of 7:3, enter in beater and pull an oar, connect slag band slurry and place 1-2h, allow two tastes fully react to each other, then extract with supercritical extraction process and obtain garlicky Rhizoma Chuanxiong extract, for subsequent use; C, select fresh ginseng, clean, stripping and slicing, mixes with fresh peeling garlic clove, with the ratio of 7:3, enter in beater and pull an oar, connect slag band slurry and place 1-2h, allow two tastes fully react to each other, then use supercritical extraction process, extract and obtain garlicky Radix Ginseng extract, for subsequent use; D, select fresh fructus lycii, clean, mix with fresh peeling garlic clove, with the ratio of 7:3, enter in beater and pull an oar, connect slag band slurry and place 1-2h, allow two tastes fully react to each other, then, with supercritical extraction process, extract the garlicky wolfberry fruit extract of acquisition, for subsequent use; E, select cadmium yellow stilbene, edulcoration, stripping and slicing, mix with fresh peeling garlic clove, with the ratio of 7:3, enter in beater and pull an oar, connect slag band slurry and place 1-2h, allow two tastes fully react to each other, then use supercritical extraction process, extract and obtain garlicky Radix Astragali extract, for subsequent use; F, get fresh Fructus Crataegi leaf, clean, making beating, constantly add peeling garlic clove and mix with it and pulls an oar, with the operation sequential of 7:3, mixing slurry is placed 1-2h, allows two tastes fully react to each other, then use supercritical extraction process, extract and obtain garlicky hawthorn flavone extract, for subsequent use; The garlicky hawthorn flavone extract 10% of garlicky Radix Astragali extract 5-10%, f step acquisition that the garlicky wolfberry fruit extract 5-20% that the garlicky Radix Ginseng extract 5-20% that the garlicky Rhizoma Chuanxiong extract 5-20% that g, the garlic polysaccharide extract 20-70% getting the acquisition of a step, b step obtain, step c obtain, Step d obtain, step e obtain, mix, obtain synthetic mixture, for subsequent use; H, get commercial hemp oil 30%, g step obtain synthetic mixture 70%, mix, obtain oily body content, for subsequent use; I, the soft gelatin capsule capsule material rubber made of edible Gelatinum oxhide, spread in equipment, is according to dosage automatically injected the oily body content that h step obtains, is pressed into the granule soft capsule meeting measurement criteria by mould; Every 1g, each 1-2 ball, every day three times.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105661551A (en) * | 2016-01-19 | 2016-06-15 | 吉林金恒制药股份有限公司 | Healthcare oil soft capsules for adjusting blood lipid |
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2015
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Patent Citations (4)
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| CN102085294A (en) * | 2009-12-03 | 2011-06-08 | 李丹 | Medicinal composition with immunoregulation effect |
| CN102100873A (en) * | 2011-01-22 | 2011-06-22 | 李文东 | Chinese patent medicine for treating heart cerebrovascular diseases and preparation method thereof |
| CN103005449A (en) * | 2013-01-14 | 2013-04-03 | 王跃进 | Medlar soft capsule enriched nutriment |
| CN103933409A (en) * | 2014-05-21 | 2014-07-23 | 王跃进 | Compound fructus psoraleae hair-blackening soft capsule |
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| CN105661551A (en) * | 2016-01-19 | 2016-06-15 | 吉林金恒制药股份有限公司 | Healthcare oil soft capsules for adjusting blood lipid |
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