CN104984014A - Medicine composition for treating feline panleukopenia and preparation method thereof - Google Patents
Medicine composition for treating feline panleukopenia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composition for treating feline panleukopenia and a preparation method thereof. The medicine composition comprises rhizoma decumbentis, phoenix-tail fern, potentilla chinensis, elegant jessamine, herba siegesbeckiae, acalypha australis, saxifraga stolonifera, brucea javanica, asthma weed, sheargrass, pyracantha fortuneana, golden cypress, indigo naturalis, herba portulacae, field pennycress, isatis root, rhizoma atractylodis macrocephalae, agaric, polygonum aviculare, schisandra chinensis, myristica fragrans, aspidium, cactuses, Chinese yams and liquorice. The medicine composition has the advantages that the medicine composition has the main effects of removing acute communicable diseases, conducting detoxification, cooling blood, prompting blood circulation and checking diarrhea and the auxiliary effects of dispelling wind-evil and relieving muscular spasm, can strengthen body resistance, eliminate evils and improve the organism immunity of sicken cats, and is short in curative period, good in curative effect, free of drug resistance and drug residues, low in cost and capable of effectively controlling illness states.
Description
Technical field
The present invention relates to field of veterinary, particularly relate to and be a kind ofly used for the treatment of pharmaceutical composition of cat distemper disease and preparation method thereof.
Background technology
Cat distemper is sick also known as feline panleukopenia, cat infectious enteritis, is the acute high degree in contact sexually transmitted disease of one of cat.Clinical manifestation is sharply reduced to principal character mainly with unexpected Fa Gaore, obstinate vomit, diarrhoea, dehydration, circulatory disturbance and leukocyte, and (not every leukopenic situation is all cat distemper, other disease also can cause leukopenia, such as feline leukemia, Hepar Felis domestica is scorching).Vaccination is incomplete or nonvaccinated cat is easy obtains cat distemper, especially maximum with the young cat at 3-5 monthly age.If female cat infected in period of pregnancy, stillborn fetus, miscarriage and nascent kitten can be caused to occur nervous symptoms, the route of infection are viruliferous urine excrement of contact or through hematophagus and flea class.The one virus that cause of disease is Parvoviridae, parvovirus belongs to.After cell entry body, can survive more than 1 year at kidney.Parvovirus can be survived the long period in the environment, but can by formalin, sodium hypochlorite (domestic disinfectant liquid) or the deactivation of the eleventh of the twelve Earthly Branches dialdehyde.
Clinical manifestation mainly contains:
Cat distemper sick incubation period is 2-9 days, and clinical symptoms is relevant with age and virus virulence.Children cat is many, and in acute onset, body temperature raises 40 ° of more than C, and vomiting, any symptom does not appear in a lot of cat, sudden death, and what have may show the ataxic symptom of myeloid form.The cat of more than 6 months is mostly in subacute clinical, and first generate heat to 40 ° and drop to room temperature after about C, 1-2 days, after 3-4 days, body temperature raises again, i.e. two-phase pattern of fever.Sick cat lassitude, anorexia, obstinate vomit, vomitus is yellow green, oral cavity and eye, nose toughness secretions, feces thickness sample, when there is diarrhoea, illustrates that animal is in end-stage disease, blood stool, serious dehydration, anemia, and severe patient is dead.This virus, except infection domestic cat, can also infect the racoon of other felids (as tiger, leopard) and mustelid (ermine) and Ursidae.The cat at each age all can infect.In most cases, the cat susceptible of less than 1 years old, infection rate can reach 70%, and mortality rate is 50%-60%, and the young cat mortality rate below 5 monthly ages reaches as high as 80%-90%, with the growth sickness rate at age reduces gradually, the cat of group support can group's outburst or full nest morbidity entirely.Primary disease all can occur throughout the year, especially multiple with winter-spring season.Morbidity cat can discharge a large amount of virus from excrement, urine, vomitus and various secretions, and virus can be survived the long period in the environment.The long-term toxin expelling of rehabilitation cat can reach more than 1 year.The cat of infection period is also propagated by hematophaguss such as flea, louse, flies.
Obviously reduce according to epidemiology, clinical symptoms and hematological examination leukocyte, can tentative diagnosis be made.Positive in conjunction with the hot Test paper of cat distemper again, can make a definite diagnosis.
At present, the emesis antibiotic medicine that cat distemper disease mainly injects hyper-immune serum, cat monoclonal antibody or correspondence is treated; Side effect is comparatively large, and drug residue is high, and price is also more expensive, and uneconomical applicable, the course for the treatment of is longer simultaneously, is also unfavorable for that the body constitution of cat is recovered.But the Chinese medicine cat distemper sick initial stage not only has the effects such as the antiviral of western modern medicine, also have antipyretic and detoxicated, the effect of removing heat from blood promoting the circulation of blood antidiarrheal, the immunity of cat can be improved, there is Chinese medicine composition and the preparation thereof of the advantageous feature such as effective and rapid, inexpensive safety, green non-pollution, pure natural property, nonhazardous, drug residue free in treatment cat distemper is sick.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition being used for the treatment of cat distemper disease, the various defects of Chinese medicine of the prior art and Western medicine can be overcome, have antipyretic and detoxicated, the effect of removing heat from blood promoting the circulation of blood diarrhea-relieving function, can strengthen the resistance against diseases of cat, strengthens its immunity, in treatment cat distemper is sick, there is pure natural, have no drug resistance, noresidue, has no side effect, evident in efficacy, specific aim is strong, through focus, not easily the advantageous feature such as recurrence.
In order to realize foregoing invention object, the invention provides a kind of pharmaceutical composition being used for the treatment of cat distemper disease, described pharmaceutical composition comprises following raw medicinal material: Radix et Rhizoma Thalictri, Herba Pteridis Multifidae, Herba Potentillae Chinensis, Herba Gelsemii Elegantis, Herba Siegesbeckiae, Herba Acalyphae, Herba Saxifragae, Fructus Bruceae, Herba Euphoubiae Hirtae, Herba clinopodii confinis (Herba Clinopodii Gracilis), fiery sour jujube, Herba Acalyphae, Cortex Phellodendri, Indigo Naturalis, Herba Portulacae, Herba Patriniae, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Polyporus, Herba Polygoni Avicularis, Fructus Schisandrae Chinensis, Semen Myristicae, Herba potentillae fulgentis, Radix et Caulis Opuntiae Dillenii, Rhizoma Dioscoreae and Radix Glycyrrhizae.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix et Rhizoma Thalictri 25-33 weight portion, Herba Pteridis Multifidae 21-30 weight portion, Herba Potentillae Chinensis 19-27 weight portion, Herba Gelsemii Elegantis 3-6 weight portion, Herba Siegesbeckiae 10-17 weight portion, Herba Acalyphae 17-26 weight portion, Herba Saxifragae 5-11 weight portion, Fructus Bruceae 6-12 weight portion, Herba Euphoubiae Hirtae 12-17 weight portion, Herba clinopodii confinis (Herba Clinopodii Gracilis) 19-29 weight portion, fire sour jujube 18-28 weight portion, Herba Acalyphae 10-15 weight portion, Cortex Phellodendri 12-19 weight portion, Indigo Naturalis 12-20 weight portion, Herba Portulacae 12-19 weight portion, Herba Patriniae 10-17 weight portion, Radix Isatidis 12-20 weight portion, Rhizoma Atractylodis Macrocephalae 22-32 weight portion, Polyporus 10-18 weight portion, Herba Polygoni Avicularis 9-15 weight portion, Fructus Schisandrae Chinensis 12-22 weight portion, Semen Myristicae 20-30 weight portion, Herba potentillae fulgentis 12-19 weight portion, Radix et Caulis Opuntiae Dillenii 12-19 weight portion, Rhizoma Dioscoreae 14-23 weight portion and Radix Glycyrrhizae 6-12 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix et Rhizoma Thalictri 30 weight portion, Herba Pteridis Multifidae 27 weight portion, Herba Potentillae Chinensis 24 weight portion, Herba Gelsemii Elegantis 5 weight portion, Herba Siegesbeckiae 15 weight portion, Herba Acalyphae 21 weight portion, Herba Saxifragae 7 weight portion, Fructus Bruceae 10 weight portion, Herba Euphoubiae Hirtae 14 weight portion, Herba clinopodii confinis (Herba Clinopodii Gracilis) 24 weight portion, fire sour jujube 21 weight portion, Herba Acalyphae 12 weight portion, Cortex Phellodendri 16 weight portion, Indigo Naturalis 17 weight portion, Herba Portulacae 15 weight portion, Herba Patriniae 12 weight portion, Radix Isatidis 16 weight portion, the Rhizoma Atractylodis Macrocephalae 27 weight portion, Polyporus 16 weight portion, Herba Polygoni Avicularis 11 weight portion, Fructus Schisandrae Chinensis 20 weight portion, Semen Myristicae 24 weight portion, Herba potentillae fulgentis 14 weight portion, Radix et Caulis Opuntiae Dillenii 17 weight portion, Rhizoma Dioscoreae 22 weight portion and Radix Glycyrrhizae 8 weight portion.
Described pharmaceutical composition also comprises Herba Thymi, Radix Cynanchi Otophylli, Eumeces Chinensis, Scorpio, Herba Ardisiae Mamillatae.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix et Rhizoma Thalictri 25-33 weight portion, Herba Pteridis Multifidae 21-30 weight portion, Herba Potentillae Chinensis 19-27 weight portion, Herba Gelsemii Elegantis 3-6 weight portion, Herba Siegesbeckiae 10-17 weight portion, Herba Acalyphae 17-26 weight portion, Herba Saxifragae 5-11 weight portion, Fructus Bruceae 6-12 weight portion, Herba Euphoubiae Hirtae 12-17 weight portion, Herba clinopodii confinis (Herba Clinopodii Gracilis) 19-29 weight portion, fire sour jujube 18-28 weight portion, Herba Acalyphae 10-15 weight portion, Cortex Phellodendri 12-19 weight portion, Indigo Naturalis 12-20 weight portion, Herba Portulacae 12-19 weight portion, Herba Patriniae 10-17 weight portion, Radix Isatidis 12-20 weight portion, Rhizoma Atractylodis Macrocephalae 22-32 weight portion, Polyporus 10-18 weight portion, Herba Polygoni Avicularis 9-15 weight portion, Fructus Schisandrae Chinensis 12-22 weight portion, Semen Myristicae 20-30 weight portion, Herba potentillae fulgentis 12-19 weight portion, Radix et Caulis Opuntiae Dillenii 12-19 weight portion, Rhizoma Dioscoreae 14-23 weight portion, Radix Glycyrrhizae 6-12 weight portion, Herba Thymi 3-7 weight portion, Radix Cynanchi Otophylli 4-8 weight portion, Eumeces Chinensis 9-16 weight portion, Scorpio 4-9 weight portion and Herba Ardisiae Mamillatae 9-14 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix et Rhizoma Thalictri 30 weight portion, Herba Pteridis Multifidae 27 weight portion, Herba Potentillae Chinensis 24 weight portion, Herba Gelsemii Elegantis 5 weight portion, Herba Siegesbeckiae 15 weight portion, Herba Acalyphae 21 weight portion, Herba Saxifragae 7 weight portion, Fructus Bruceae 10 weight portion, Herba Euphoubiae Hirtae 14 weight portion, Herba clinopodii confinis (Herba Clinopodii Gracilis) 24 weight portion, fire sour jujube 21 weight portion, Herba Acalyphae 12 weight portion, Cortex Phellodendri 16 weight portion, Indigo Naturalis 17 weight portion, Herba Portulacae 15 weight portion, Herba Patriniae 12 weight portion, Radix Isatidis 16 weight portion, the Rhizoma Atractylodis Macrocephalae 27 weight portion, Polyporus 16 weight portion, Herba Polygoni Avicularis 11 weight portion, Fructus Schisandrae Chinensis 20 weight portion, Semen Myristicae 24 weight portion, Herba potentillae fulgentis 14 weight portion, Radix et Caulis Opuntiae Dillenii 17 weight portion, Rhizoma Dioscoreae 22 weight portion, Radix Glycyrrhizae 8 weight portion, Herba Thymi 4 weight portion, Radix Cynanchi Otophylli 5 weight portion, Eumeces Chinensis 12 weight portion, Scorpio 6 weight portion and Herba Ardisiae Mamillatae 11 weight portion.
In order to better realize goal of the invention, the present invention also provides a kind of preparation method being used for the treatment of the pharmaceutical composition of cat distemper disease, and when the dosage form of described pharmaceutical composition is injectable powder, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
In order to better realize goal of the invention, the present invention also provides a kind of preparation method being used for the treatment of the pharmaceutical composition of cat distemper disease, and when the dosage form of described Chinese medicine is sodium chloride injection, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 1 ~ 3g that second step obtains, adds sodium chloride 90 ~ 110g, add 1000ml water for injection, stirs and makes it dissolve; Inject water to 10000ml; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Subpackage embedding, every bottle of 250ml, sterilizing.
The invention has the beneficial effects as follows: pharmaceutical composition of the present invention is with antipyretic and detoxicated, removing heat from blood promoting the circulation of blood antidiarrheal is main, be auxiliary with suppressing liver-wind to relieve spasm, the resistance against diseases of cat can be strengthened, strengthen its immunity, in treatment cat distemper is sick, there is pure natural, have no drug resistance, noresidue, have no side effect, evident in efficacy, specific aim be strong, through focus, the not easily advantageous feature such as recurrence.
Detailed description of the invention
Cat distemper is sick, and mainly owing to infecting, virus causes, from the angle of the traditional Chinese medical science, be exactly the disease that being invaded by exogenous pathogen pestilential pathogen produces, to generate heat, diarrhoea, vomiting, not for taking food as cardinal symptom, the immunity of self of cat can be reduced again simultaneously, the course of disease is lengthened, increase the weight of the state of an illness further, be unfavorable for the rehabilitation of cat.
If the Western medicine of some drug main antibiotic being used for the treatment of cat distemper disease on the market and so at present, side effect is comparatively large, and drug residue is high, and price is also more expensive, and uneconomical applicable, the course for the treatment of is longer simultaneously, is also unfavorable for that the body constitution of cat is recovered.
Chinese veterinarian thinks: according to Chinese Ancient Books works " collection rhythm " even tone soul rhythm: " pestilence, epidemic disease also.", and the Tang Dynasty writer LIU Zong-yuan is in " Yongzhou Temple of Dragon Prosperity breath earth note style of writing ": " southern many epidemic diseases, Lao Zhexian is dead.", being use till today as pestilence one word from ancient times, using the works of this word the earliest, may be the micro-purport of " the Master of Preserving Simplicity " interior section: " then defy through pestilence, meet misfortune then stealth." pestilence is early on the books in Chinese historical data.As " all gift heavenly officials tombs are killed " is recorded: " physician slaps the disease of foster ten thousand people, all has pestilence disease when four." " Springs and Autumns of Master Lü last month of spring discipline " record: " summer weather in spring in season, the then people's many diseases epidemic disease." illustrate and at that time certain level is reached to the understanding of pestilence, think that pestilence all can occur throughout the year, one of reason is gas abnormal due to season, is caused by " gas time non-".The Chinese medical book Huangdi's Internal Classics of earliest extant is also on the books.As " Plain Questions acupuncture manipulation opinion " points out: " five types of pestilence extremely, all to dye easily, without asking size, condition of illness is similar ..., in healthy energy is deposited, heresy can not be done, preventing the invasion of infectious pathogen." " Plain Questions instinct sick " section: " and the moon of fainting is not given up the throne, and namely strong wind is early lifted, time rain do not fall, wet order is not changed, people's suffering from epidemic febrile disease epidemic disease, and defect gives up.Humorously, people's disease is arthrodynia of the extremities, head's pain all, latent heat restlessness, the dry taking fluids profusely of throat." point out that pestilence has the features such as infectiousness, popularity, clinical manifestation are similar, morbidity is relevant with weather, as long as and think " healthy energy deposit in ", with regard to energy " preventing the invasion of infectious pathogen ".Ming Dynasty doctor Wu can witness again the miserable condition of pestilence at that time, on the basis of forefathers' relevant discussion, carries out intensive observation, discussion to pestilence.Its " treatise on pestilence " of showing is the monograph that pestilence is discussed by China, has carried out detailed discussion to pestilence.Think " pestilence for sick, the non-cold non-summer-heat non-wet of non-wind is do not have a kind of unusual pathogen to feel in this world." point out that the virulence factor of pestilence is " unusual pathogen ", also known as " pestilential pathogen ", " epidemic miasma " " epidemic pathogenic factor " etc., be the original idea to the pestilence cause of disease.
Pharmaceutical composition of the present invention is followed antipyretic and detoxicated, the principle of removing heat from blood promoting the circulation of blood antidiarrheal, provide a kind of pharmaceutical composition being used for the treatment of cat distemper disease, comprise following raw medicinal material: Radix et Rhizoma Thalictri, Herba Pteridis Multifidae, Herba Potentillae Chinensis, Herba Gelsemii Elegantis, Herba Siegesbeckiae, Herba Acalyphae, Herba Saxifragae, Fructus Bruceae, Herba Euphoubiae Hirtae, Herba clinopodii confinis (Herba Clinopodii Gracilis), fiery sour jujube, Herba Acalyphae, Cortex Phellodendri, Indigo Naturalis, Herba Portulacae, Herba Patriniae, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Polyporus, Herba Polygoni Avicularis, Fructus Schisandrae Chinensis, Semen Myristicae, Herba potentillae fulgentis, Radix et Caulis Opuntiae Dillenii, Rhizoma Dioscoreae, Radix Glycyrrhizae; Preferably, Herba Thymi, Radix Cynanchi Otophylli, Eumeces Chinensis, Scorpio, Herba Ardisiae Mamillatae can also be comprised.Wherein, Radix et Rhizoma Thalictri, Herba Pteridis Multifidae, Herba Potentillae Chinensis, Herba Gelsemii Elegantis, Herba Siegesbeckiae, Herba Acalyphae, Herba Saxifragae antiviral, simultaneously clear pestilence virus killing, again can cooling blood for hemostasis, Fructus Bruceae, Herba Euphoubiae Hirtae, Herba clinopodii confinis (Herba Clinopodii Gracilis), fiery sour jujube, Herba Acalyphae removing toxic substances dysentery relieving; Cortex Phellodendri, Indigo Naturalis, Herba Portulacae, Herba Patriniae, Radix Isatidis heat-clearing and toxic substances removing, help with eliminating dampness by diuresis medicine Shi Xiequyou roads such as the Rhizoma Atractylodis Macrocephalae, Polyporus, Herba Polygoni Avicularis, Fructus Schisandrae Chinensis, Semen Myristicae, Herba potentillae fulgentis, Radix et Caulis Opuntiae Dillenii astringing to arrest diarrhea simultaneously; Simultaneously solid protection taste again, therefore with medicines such as Rhizoma Dioscoreae, Radix Glycyrrhizaes, Herba Thymi, Radix Cynanchi Otophylli, Eumeces Chinensis, Scorpio, Herba Ardisiae Mamillatae suppressing liver-wind to relieve spasm.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Radix et Rhizoma Thalictri: bitter, cold.Enter the heart, liver, gallbladder, large intestine four warp.Heat clearing and damp drying, eliminating fire and detoxication.For enteritis, dysentery, jaundice, conjunctival congestion and swelling pain.Heat clearing and damp drying, removing toxic substances.Control dysentery, enteritis, infectious hepatitis, flu, measles, carbuncle furuncle, conjunctivitis.
Herba Pteridis Multifidae: light, micro-hardship is cool.Clearing away heat-damp and promoting diuresis, removing toxic substances dysentery relieving, cooling blood for hemostasis.For dysentery, gastroenteritis, hepatitis, urinary system infection, cat fever, laryngopharynx swelling and pain, leucorrhea, metrorrhagia, pesticide intoxication; Traumatic hemorrhage is controlled in external, burn and scald.
Herba Potentillae Chinensis: bitter, cold.Return liver, large intestine channel.Heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.For bloody dysentery stomachache, chronic dysentery is more than, bleeding hemorrhoids, carbuncle sore tumefacting virus.
Herba Gelsemii Elegantis: pungent; Bitter; Warm in nature; Large poison.Dispel the wind counteracting toxic substances; Mass dissipating and swelling eliminating; Pain relieving.Main mange; Eczema; Scrofula; Carbuncle; Furuncle; Traumatic injury; Rheumatic arthralgia; Neuralgia.
Herba Siegesbeckiae: pungent, bitter, cold.Return liver, kidney channel.Wind-damp dispelling, sharp joint, removing toxic substances.For rheumatic arthralgia, muscles and bones is unable, soreness of the waist and knees, quadriplegia, hemiplegia, rubella eczema.
Herba Acalyphae: bitter, puckery, cool.Heat-clearing and toxic substances removing, removing food stagnancy, dysentery relieving, hemostasis.For enteritis, bacillary dysentery, amebic dysentery, infantile malnutrition, hepatitis, malaria, spits blood, epistaxis, and hematuria, has blood in stool, metrorrhagia; Carbuncle furuncle infections is controlled in external, traumatic hemorrhage, eczema, dermatitis, venom.
Herba Saxifragae: bitter, acrid, cold.Heat-clearing and toxic substances removing.For fever of children, cough and asthma; Otitis media is controlled in external, and auricle festers, furuncle, furuncle and phyma, eczema.
Fructus Bruceae: bitter, cold.Return large intestine, Liver Channel.Heat-clearing and toxic substances removing, preventing the attack (or recurrence) of malaria, dysentery relieving, corrosion wart.For dysentery, malaria; External treatment wart, clavus.
Herba Euphoubiae Hirtae: sad, cold.Return lung; Liver Channel.Heat clearing away, removing toxic substances, lactogenesis, eliminating dampness by diuresis, antipruritic.Control acute enteritis, bacillary dysentery, gonorrhea, hematuria, lung abscess, acute mastitis, furuncle, toxic swelling, eczema, tinea pedis, skin pruritus.
Herba clinopodii confinis (Herba Clinopodii Gracilis): toil is cool.Expelling wind and clearing away heat, dissipating blood stasis for subsidence of swelling.Cure cold headache, bacillary dysentery, enteritis, acute mastitis, furuncle, traumatic injury, metrorrhagia, urticaria.
Fire sour jujube (really): sweet, sour is flat.Really: removing food stagnancy dysentery relieving, promoting blood circulation and hemostasis.For dyspepsia, enteritis, dysentery, infantile malnutrition, metrorrhagia, leucorrhea, puerperal abdonimal pain.Root: clearing away heat and cooling blood.For chronic consumptive disease osteopyrexia and fever, hepatitis, traumatic injury, bones and muscles pain, lumbago, metrorrhagia, leucorrhea, menoxenia, spits blood, has blood in stool.Leaf: heat-clearing and toxic substances removing.Sore swollen toxin is controlled in external application.
Herba Acalyphae: bitter, puckery, cool.Heat-clearing and toxic substances removing, removing food stagnancy, dysentery relieving, hemostasis.For enteritis, bacillary dysentery, amebic dysentery, infantile malnutrition, hepatitis, malaria, spits blood, epistaxis, and hematuria, has blood in stool, metrorrhagia; Carbuncle furuncle infections is controlled in external, traumatic hemorrhage, eczema, dermatitis, venom.
Cortex Phellodendri: bitter, cold.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Indigo Naturalis: salty in the mouth, cold in nature, return Liver Channel.There is effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire, send out the cards such as all cards of pyretic toxicity such as speckle, haematemesis, laryngopharynx swelling and pain, herpes eczema, liver-fire invading the lung, cough chest pain, sputum mixed with blood, high hot infantile convulsion, convulsion with spasms for epidemic febrile disease.
Herba Portulacae: cold in nature, sweet in the mouth acid; GUIXIN, liver, spleen, large intestine channel.Compendium of Material Medica: " loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property." " Kaibao Bencao ": not " clothes not white all the year round.Control carbuncle skin ulcer, kill parasites.Raw juice of smashing takes, and when disliking thing under profit, removes tapeworm." function heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, hemostasis removing heat from blood.Cure mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the diseases such as mastitis.Herba Patriniae:
Radix Isatidis: nature and flavor, bitter cold.Heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Cure mainly maculae caused by violent heat pathogen, high heat headache, major part pestilence, crimson tongue is purple dark, scarlet fever, erysipelas, mumps, sore throat, and skin ulcer is swollen, carbuncle, chickenpox, measles, hepatitis, influenza, epidemic encephalitis, encephalitis b, pneumonia, and coma tells nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, return spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cure mainly the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration.
Polyporus: sweet in the mouth, light, flat.Enter the heart, spleen, stomach, lung, kidney, warp.Collective Notes to the Canon of Materia medica note has: " maple Siberian cocklebur, its skin de-black makes block like pig dung, thus with name it.Meat Bai Ershi person is good, with it casting skin of pruning." effect had: promoting diuresis to eliminate damp pathogen.Control dysuria, edema, to have loose bowels, stranguria with turbid discharge, leukorrhagia.
Herba Polygoni Avicularis: bitter, cold; Enter urinary bladder channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " diuresis.Control five types of stranguria nebulousurine, pyretic stranguria, stasis of blood essence is puckery closes the border key, and controls married woman's stagnation of QI, damp and hot in stomach, or the disease of leucorrhea." Compendium of Material Medica: " control cholera, jaundice, diuresis." diuresis, heat clearing away, parasite killing.Cure mainly and control pyretic stranguria, the difficulty in urination, jaundice, the erosion of the vulva, leucorrhea, ascarid, infantile malnutrition, hemorrhoid swell, eczema.
Fructus Schisandrae Chinensis: sour, sweet, temperature.Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Semen Myristicae: pungent, temperature.Return spleen, stomach, large intestine channel.Warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents.For Deficiency and coldness of spleen and stomach, incessant chronic diarrhea, abdominal distention, lack of appetite is vomitted.
Herba potentillae fulgentis: cold; Pained.Return spleen; Large intestine channel.Heat-clearing and toxic substances removing, relieving diarrhea with astringents, cooling blood for hemostasis.Main red white dysentery; Enteritis, diarrhea; Discharging fresh blood stool; Pulmonary tuberculosis is spat blood; Spit blood; Bleeding not during menses; Traumatic hemorrhage; Furuncle; Scald burn
Radix et Caulis Opuntiae Dillenii: bitter, cool.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, benefiting stomach and stopping pain, antitussive.For taste-blindness rate, acute dysentery, cough; Mumps is controlled in external, mastitis, carbuncle furuncle and phyma poison, venom, burn and scald.
Rhizoma Dioscoreae: sweet in the mouth, property is put down, return lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red card such as swollen, fat of frequent micturition of quenching one's thirst, premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Herba Thymi: acrid in the mouth; Property is put down.Warming spleen and stomach for dispelling cold, wind dispelling pain relieving.Control tell inverse, stomachache, have loose bowels, lack of appetite painful abdominal mass is swollen, cough due to wind and cold, and pharyngeal swelling is had a toothache, general pain, skin pruritus.
Radix Cynanchi Otophylli: sweet, acrid, warm.Expelling wind and removing dampness, removing toxic substances spasmolytic.For rheumatic ostalgia, rubella is scratched where it itches, epilepsy, lyssodexis, venom.
Eumeces Chinensis: salty, cold.Removing toxic substances and promoting subsidence of swelling, spasmolytic is dispeled the wind.For tuberculous lymphadenitis, breast carcinoma, lung abscess, epilepsy, rheumatism skin is itched and sore.
Scorpio: pungent, flat.Return Liver Channel.Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Herba Ardisiae Mamillatae: be the Herb of Myrsinacea plant breast hair Herba Ardisiae Japonicae.Bitter; Pungent; Cool in nature.Dispeling the wind, it is wet to scrape; Heat-clearing and toxic substances removing; Promoting blood circulation and hemostasis.Main air pain of dampness syndrome; Yellow cellulitis; Dysentery; Hemoptysis; Spit blood; Have blood in stool; Amenorrhea; Prolonged lochia; Traumatic injury; Mastalgia; Treat skin ulcer
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 pharmaceutical composition 1
Embodiments provide a kind of pharmaceutical composition being used for the treatment of cat distemper disease, be made up of the raw medicinal material of following parts by weight: Radix et Rhizoma Thalictri 30 weight portion, Herba Pteridis Multifidae 27 weight portion, Herba Potentillae Chinensis 24 weight portion, Herba Gelsemii Elegantis 5 weight portion, Herba Siegesbeckiae 15 weight portion, Herba Acalyphae 21 weight portion, Herba Saxifragae 7 weight portion, Fructus Bruceae 10 weight portion, Herba Euphoubiae Hirtae 14 weight portion, Herba clinopodii confinis (Herba Clinopodii Gracilis) 24 weight portion, fire sour jujube 21 weight portion, Herba Acalyphae 12 weight portion, Cortex Phellodendri 16 weight portion, Indigo Naturalis 17 weight portion, Herba Portulacae 15 weight portion, Herba Patriniae 12 weight portion, Radix Isatidis 16 weight portion, the Rhizoma Atractylodis Macrocephalae 27 weight portion, Polyporus 16 weight portion, Herba Polygoni Avicularis 11 weight portion, Fructus Schisandrae Chinensis 20 weight portion, Semen Myristicae 24 weight portion, Herba potentillae fulgentis 14 weight portion, Radix et Caulis Opuntiae Dillenii 17 weight portion, Rhizoma Dioscoreae 22 weight portion and Radix Glycyrrhizae 8 weight portion.
Its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 3 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 hours under the condition of 9 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 4 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Embodiment 2 pharmaceutical composition 2
Embodiments provide a kind of pharmaceutical composition being used for the treatment of cat distemper disease, be made up of the raw medicinal material of following parts by weight: Radix et Rhizoma Thalictri 30 weight portion, Herba Pteridis Multifidae 27 weight portion, Herba Potentillae Chinensis 24 weight portion, Herba Gelsemii Elegantis 5 weight portion, Herba Siegesbeckiae 15 weight portion, Herba Acalyphae 21 weight portion, Herba Saxifragae 7 weight portion, Fructus Bruceae 10 weight portion, Herba Euphoubiae Hirtae 14 weight portion, Herba clinopodii confinis (Herba Clinopodii Gracilis) 24 weight portion, fire sour jujube 21 weight portion, Herba Acalyphae 12 weight portion, Cortex Phellodendri 16 weight portion, Indigo Naturalis 17 weight portion, Herba Portulacae 15 weight portion, Herba Patriniae 12 weight portion, Radix Isatidis 16 weight portion, the Rhizoma Atractylodis Macrocephalae 27 weight portion, Polyporus 16 weight portion, Herba Polygoni Avicularis 11 weight portion, Fructus Schisandrae Chinensis 20 weight portion, Semen Myristicae 24 weight portion, Herba potentillae fulgentis 14 weight portion, Radix et Caulis Opuntiae Dillenii 17 weight portion, Rhizoma Dioscoreae 22 weight portion, Radix Glycyrrhizae 8 weight portion, Herba Thymi 4 weight portion, Radix Cynanchi Otophylli 5 weight portion, Eumeces Chinensis 12 weight portion, Scorpio 6 weight portion and Herba Ardisiae Mamillatae 11 weight portion.
Its preparation method is as follows:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 36 hours under the condition of 10 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 60 minutes at this, the micron particles of acquisition 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets the mixed powder 3g that second step obtains, adds sodium chloride 110g, add 1000ml water for injection, stirs and makes it dissolve; Inject water to 10000ml; With 0.24 μm of filtering with microporous membrane; Subpackage embedding, every bottle of 250ml, sterilizing.
The toxicity test of pharmaceutical composition:
1, trial drug
Choose Radix et Rhizoma Thalictri 30g, Herba Pteridis Multifidae 27g, Herba Potentillae Chinensis 24g, Herba Gelsemii Elegantis 5g, Herba Siegesbeckiae 15g, Herba Acalyphae 21g, Herba Saxifragae 7g, Fructus Bruceae 10g, Herba Euphoubiae Hirtae 14g, Herba clinopodii confinis (Herba Clinopodii Gracilis) 24g, fiery sour jujube 21g, Herba Acalyphae 12g, Cortex Phellodendri 16g, Indigo Naturalis 17g, Herba Portulacae 15g, Herba Patriniae 12g, Radix Isatidis 16g, Rhizoma Atractylodis Macrocephalae 27g, Polyporus 16g, Herba Polygoni Avicularis 11g, Fructus Schisandrae Chinensis 20g, Semen Myristicae 24g, Herba potentillae fulgentis 14g, Radix et Caulis Opuntiae Dillenii 17g, Rhizoma Dioscoreae 22g and Radix Glycyrrhizae 8g mix, be ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
Contrast test
To see and treat patients cat 128 example suffering from cat distemper disease in April ,-2014 in January, 2011 in animal and veterinary station, Wuhan, Hubei, wherein, cure 122 examples, wherein 6 routine invalid death, cure rate reaches 95.3%.
Model case 1
On March 15th, 2011, the persian cat inappetence of Zhao, spirit is depressed, and sometimes vomit, soft stools band blood, breath malodor, body temperature 39.6 DEG C, is diagnosed as cat distemper disease after diagnosis.Use the injectable powder intramuscular injection of embodiment 1; Each 120mg, every day 1 time.Second day, suffer from cat spirit and take a turn for the better, the 3rd day, dysentery disappearance body temperature was down to 38.0 DEG C; Continue injection 2 days.Suffer from cat body temperature normal, occur appetite, recovery from illness.
Model case 2
In April, 2012, the spotted cat of Chen is gone to a doctor, this cat body temperature 40.1 DEG C, and vomitus is that yellow green appetite is absolutely useless, and down in spirits, there is secretions at canthus, thirst and liking drink, draws water sample loose stool band blood.Once failed to respond to any medical treatment with atropine and chloromycetin elsewhere.Be diagnosed as cat distemper disease after diagnosis, injection embodiment 2 sodium chloride injection, every day 1 time, within second day, suffer from cat temperature decline to 39.1 DEG C, vomiting stops, and spirit takes a turn for the better, and dysentery disappears; Third body temperature is normal, suffers from cat recovery from illness.
Model case 3
On March 18th, 2013, the spotted cat of Cai is gone to a doctor, this cat lassitude, anorexia, body temperature 39.8 DEG C, and stomachache groan, loose stool band blood, is diagnosed as cat distemper disease after diagnosis.Injection hyper-immune serum 0.2 milliliter 2 days is invalid, the injectable powder of injection on March 20 embodiment 1; Each 120mg, every day 1 time, March 21, suffer from cat spirit and take a turn for the better, depletion of blood in the pasty state of defecating March 22, body temperature is normal.Continue injection 2 days, appetite is normal, recovery from illness.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. be used for the treatment of the pharmaceutical composition of cat distemper disease, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Radix et Rhizoma Thalictri, Herba Pteridis Multifidae, Herba Potentillae Chinensis, Herba Gelsemii Elegantis, Herba Siegesbeckiae, Herba Acalyphae, Herba Saxifragae, Fructus Bruceae, Herba Euphoubiae Hirtae, Herba clinopodii confinis (Herba Clinopodii Gracilis), fiery sour jujube, Herba Acalyphae, Cortex Phellodendri, Indigo Naturalis, Herba Portulacae, Herba Patriniae, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Polyporus, Herba Polygoni Avicularis, Fructus Schisandrae Chinensis, Semen Myristicae, Herba potentillae fulgentis, Radix et Caulis Opuntiae Dillenii, Rhizoma Dioscoreae and Radix Glycyrrhizae.
2. the pharmaceutical composition being used for the treatment of cat distemper disease according to claim 1, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix et Rhizoma Thalictri 25-33 weight portion, Herba Pteridis Multifidae 21-30 weight portion, Herba Potentillae Chinensis 19-27 weight portion, Herba Gelsemii Elegantis 3-6 weight portion, Herba Siegesbeckiae 10-17 weight portion, Herba Acalyphae 17-26 weight portion, Herba Saxifragae 5-11 weight portion, Fructus Bruceae 6-12 weight portion, Herba Euphoubiae Hirtae 12-17 weight portion, Herba clinopodii confinis (Herba Clinopodii Gracilis) 19-29 weight portion, fire sour jujube 18-28 weight portion, Herba Acalyphae 10-15 weight portion, Cortex Phellodendri 12-19 weight portion, Indigo Naturalis 12-20 weight portion, Herba Portulacae 12-19 weight portion, Herba Patriniae 10-17 weight portion, Radix Isatidis 12-20 weight portion, Rhizoma Atractylodis Macrocephalae 22-32 weight portion, Polyporus 10-18 weight portion, Herba Polygoni Avicularis 9-15 weight portion, Fructus Schisandrae Chinensis 12-22 weight portion, Semen Myristicae 20-30 weight portion, Herba potentillae fulgentis 12-19 weight portion, Radix et Caulis Opuntiae Dillenii 12-19 weight portion, Rhizoma Dioscoreae 14-23 weight portion and Radix Glycyrrhizae 6-12 weight portion.
3. the pharmaceutical composition being used for the treatment of cat distemper disease according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix et Rhizoma Thalictri 30 weight portion, Herba Pteridis Multifidae 27 weight portion, Herba Potentillae Chinensis 24 weight portion, Herba Gelsemii Elegantis 5 weight portion, Herba Siegesbeckiae 15 weight portion, Herba Acalyphae 21 weight portion, Herba Saxifragae 7 weight portion, Fructus Bruceae 10 weight portion, Herba Euphoubiae Hirtae 14 weight portion, Herba clinopodii confinis (Herba Clinopodii Gracilis) 24 weight portion, fire sour jujube 21 weight portion, Herba Acalyphae 12 weight portion, Cortex Phellodendri 16 weight portion, Indigo Naturalis 17 weight portion, Herba Portulacae 15 weight portion, Herba Patriniae 12 weight portion, Radix Isatidis 16 weight portion, the Rhizoma Atractylodis Macrocephalae 27 weight portion, Polyporus 16 weight portion, Herba Polygoni Avicularis 11 weight portion, Fructus Schisandrae Chinensis 20 weight portion, Semen Myristicae 24 weight portion, Herba potentillae fulgentis 14 weight portion, Radix et Caulis Opuntiae Dillenii 17 weight portion, Rhizoma Dioscoreae 22 weight portion and Radix Glycyrrhizae 8 weight portion.
4. the pharmaceutical composition being used for the treatment of cat distemper disease according to any one of claim 1-3, is characterized in that, described pharmaceutical composition also comprises Herba Thymi, Radix Cynanchi Otophylli, Eumeces Chinensis, Scorpio, Herba Ardisiae Mamillatae.
5. the pharmaceutical composition being used for the treatment of cat distemper disease according to any one of claim 1-4, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix et Rhizoma Thalictri 25-33 weight portion, Herba Pteridis Multifidae 21-30 weight portion, Herba Potentillae Chinensis 19-27 weight portion, Herba Gelsemii Elegantis 3-6 weight portion, Herba Siegesbeckiae 10-17 weight portion, Herba Acalyphae 17-26 weight portion, Herba Saxifragae 5-11 weight portion, Fructus Bruceae 6-12 weight portion, Herba Euphoubiae Hirtae 12-17 weight portion, Herba clinopodii confinis (Herba Clinopodii Gracilis) 19-29 weight portion, fire sour jujube 18-28 weight portion, Herba Acalyphae 10-15 weight portion, Cortex Phellodendri 12-19 weight portion, Indigo Naturalis 12-20 weight portion, Herba Portulacae 12-19 weight portion, Herba Patriniae 10-17 weight portion, Radix Isatidis 12-20 weight portion, Rhizoma Atractylodis Macrocephalae 22-32 weight portion, Polyporus 10-18 weight portion, Herba Polygoni Avicularis 9-15 weight portion, Fructus Schisandrae Chinensis 12-22 weight portion, Semen Myristicae 20-30 weight portion, Herba potentillae fulgentis 12-19 weight portion, Radix et Caulis Opuntiae Dillenii 12-19 weight portion, Rhizoma Dioscoreae 14-23 weight portion, Radix Glycyrrhizae 6-12 weight portion, Herba Thymi 3-7 weight portion, Radix Cynanchi Otophylli 4-8 weight portion, Eumeces Chinensis 9-16 weight portion, Scorpio 4-9 weight portion, Herba Ardisiae Mamillatae 9-14 weight portion.
6. the pharmaceutical composition being used for the treatment of cat distemper disease according to any one of claim 1-5, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix et Rhizoma Thalictri 30 weight portion, Herba Pteridis Multifidae 27 weight portion, Herba Potentillae Chinensis 24 weight portion, Herba Gelsemii Elegantis 5 weight portion, Herba Siegesbeckiae 15 weight portion, Herba Acalyphae 21 weight portion, Herba Saxifragae 7 weight portion, Fructus Bruceae 10 weight portion, Herba Euphoubiae Hirtae 14 weight portion, Herba clinopodii confinis (Herba Clinopodii Gracilis) 24 weight portion, fire sour jujube 21 weight portion, Herba Acalyphae 12 weight portion, Cortex Phellodendri 16 weight portion, Indigo Naturalis 17 weight portion, Herba Portulacae 15 weight portion, Herba Patriniae 12 weight portion, Radix Isatidis 16 weight portion, the Rhizoma Atractylodis Macrocephalae 27 weight portion, Polyporus 16 weight portion, Herba Polygoni Avicularis 11 weight portion, Fructus Schisandrae Chinensis 20 weight portion, Semen Myristicae 24 weight portion, Herba potentillae fulgentis 14 weight portion, Radix et Caulis Opuntiae Dillenii 17 weight portion, Rhizoma Dioscoreae 22 weight portion, Radix Glycyrrhizae 8 weight portion, Herba Thymi 4 weight portion, Radix Cynanchi Otophylli 5 weight portion, Eumeces Chinensis 12 weight portion, Scorpio 6 weight portion and Herba Ardisiae Mamillatae 11 weight portion.
7. the pharmaceutical composition being used for the treatment of cat distemper disease according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
8. the pharmaceutical composition being used for the treatment of cat distemper disease according to any one of claim 1-6, is characterized in that, when the dosage form of described Chinese medicine is sodium chloride injection, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 1 ~ 3g that second step obtains, adds sodium chloride 90 ~ 110g, add 1000ml water for injection, stirs and makes it dissolve; Inject water to 10000ml; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Subpackage embedding, every bottle of 250ml, sterilizing.
9. the preparation method being used for the treatment of the pharmaceutical composition of cat distemper disease as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
10. the preparation method being used for the treatment of the pharmaceutical composition of cat distemper disease as described in any one of claim 1-6, is characterized in that, when the dosage form of described Chinese medicine is sodium chloride injection, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 1 ~ 3g that second step obtains, adds sodium chloride 90 ~ 110g, add 1000ml water for injection, stirs and makes it dissolve; Inject water to 10000ml; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Subpackage embedding, every bottle of 250ml, sterilizing.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288312A (en) * | 2015-12-04 | 2016-02-03 | 山东新希望六和集团有限公司 | Pharmaceutical composition for treating infectious bovine meningitis and preparation method thereof |
| CN107569516A (en) * | 2017-08-16 | 2018-01-12 | 北京京蒙细胞生物科技股份有限公司 | A kind of medicine for controlling cat distemper heat and its preparation method and application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1207911A (en) * | 1997-08-08 | 1999-02-17 | 梁广斌 | Antiviral veterinary injection and preparation method thereof |
| CN102600419A (en) * | 2012-03-27 | 2012-07-25 | 高丽丽 | Chinese medicinal composition for treating chronic appendagitis, and preparation method thereof |
| CN104288317A (en) * | 2014-09-30 | 2015-01-21 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine veterinary injection with antiviral, antibacterial and anti-inflammatory effects and preparation method thereof |
-
2015
- 2015-08-04 CN CN201510471406.2A patent/CN104984014A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1207911A (en) * | 1997-08-08 | 1999-02-17 | 梁广斌 | Antiviral veterinary injection and preparation method thereof |
| CN102600419A (en) * | 2012-03-27 | 2012-07-25 | 高丽丽 | Chinese medicinal composition for treating chronic appendagitis, and preparation method thereof |
| CN104288317A (en) * | 2014-09-30 | 2015-01-21 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine veterinary injection with antiviral, antibacterial and anti-inflammatory effects and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王成等: "《中兽医诊疗技术》", 31 August 2012, 河南科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288312A (en) * | 2015-12-04 | 2016-02-03 | 山东新希望六和集团有限公司 | Pharmaceutical composition for treating infectious bovine meningitis and preparation method thereof |
| CN107569516A (en) * | 2017-08-16 | 2018-01-12 | 北京京蒙细胞生物科技股份有限公司 | A kind of medicine for controlling cat distemper heat and its preparation method and application |
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