CN104957561A - Sleep improving and pressure relieving composition and preparation thereof - Google Patents
Sleep improving and pressure relieving composition and preparation thereof Download PDFInfo
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- CN104957561A CN104957561A CN201510322131.6A CN201510322131A CN104957561A CN 104957561 A CN104957561 A CN 104957561A CN 201510322131 A CN201510322131 A CN 201510322131A CN 104957561 A CN104957561 A CN 104957561A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a sleep improving and pressure relieving composition and a preparation thereof. The composition comprises the following raw materials in parts by weight: 7-9 parts of passion fruit powder, 3-5 parts of semen zizyphi jujubae, 1-3 parts of albizia julibrissin, 6-10 parts of tuber fleeceflower stem, 0.1-0.5 part of gama-aminobutyric acid (GABA), 0.05-0.1 part of glycine, 0.01-0.05 part of L-tryptophan, 0.00007-0.00022 part of vitamin B6, and 0.01-0.02 part of sucralose. The beneficial effects of the composition are that the composition can effectively improve sleep and relieve pressure, has less side effects compared to central nervous inhibitory drugs in the prior art system, has no adverse reactions, tastes sweet, sour and palatable, and has excellent flavor.
Description
Technical field
The present invention relates to food or field of health care products, be particularly a kind ofly improved sleep and help the composition of releasing the pressure and preparation thereof.
Background technology
The allegro life of modern city, and derive from the pressure of work, life etc., a lot of people is had difficulty in going to sleep at dead of night, even if the sleep had also is easy to wake up, poor sleeping quality.The numerical monitor that the World Health Organization announces, the people in the whole world nearly 1/4 is by insomnia puzzlement, and be often close on 8.6 hundred million people and suffer from insomnia depressive disorder, only China just has 0.75 hundred million.Sleep-disorder modal for insomnia, show as difficulty falling asleep, Yi Xing, early awakening, sleep quality are low inferior.Short-term makes wan and sallow, quickening aging; The serious a series of stiff reaction of then generation, as tired, dizzy, headache, hypomnesia, nervous, perspire, mood change, cause the normal rhythm disorder of brain excitement and suppression eventually, generation nervous function disease, as neurasthenia etc.And the medicine being used for the treatment of sleep-disorder is at present mostly the depressor of nerve centre such as barbiturates, Benzodiazepines, this kind of medicine is all along with either large or small side effect or bad reaction, as slight anesthetic effect, Consciousness degree decline, sleepy, weak, dry etc.Be exactly utilize the large compound of the Chinese medicine of traditional theory of traditional Chinese medical science for nursing one's health the another kind of product of sleep-disorder, but often onset is slow, and taste is more difficult is accepted.
Application number 201410030361.0 denomination of invention: " a kind of there is the composition and application thereof that improving water flood helps to release the pressure; its claim 1 discloses a kind of composition having improving water flood and help to release the pressure; it is characterized in that, described tealeaves is at least one in black tea, green tea, oolong tea, Pu'er tea ".But caffeine contained in tealeaves has excited effect, disagrees with the function of improving water flood.
Therefore prior art exists many defects, be badly in need of Improvement and perfection.
Summary of the invention
The technical problem to be solved in the present invention be to provide a kind of can effectively improving water flood help to release the pressure effect, have no adverse reaction and taste sour and sweet palatability, savory composition and preparation thereof.
Have the composition that improving water flood helps to release the pressure, described composition comprises the raw material of following weight portion: passionfruit powder 7-9 part, spina date seed 5-3 part, Flos Albiziae 3-1 part, Polygonum multiflower knotweed 10-6 part, GABA (GABA) 0.1-0.5 part, glycine 0.05-0.1 part, L-Trp 0.01-0.05 part, vitamin B6 0.00007-0.00022 part, Sucralose 0.01-0.02 part;
This passionfruit powder is obtained by following steps:
S1: the passionflower fresh fruit of cleaning is shelled, remove seed after making beating obtain containing soluble solid be 10 ~ 12 ° of Bx, total acid content is 3 ~ 5%, pH value be 3.0 ± 0.5 passionflower magma for subsequent use;
S2: the passionflower magma freeze concentration obtained by S1 obtains containing the dense sauce of passionflower that soluble solid is 40 ~ 60 ° of Bx;
S3: it is freezing that the dense sauce of the passionflower obtained by S2 is placed in the temperature of-50 DEG C ~-60 DEG C, enters crusher in crushing and obtains the particle that diameter is less than 3mm after the dense sauce of whole passionflower freezes;
S4: the particle sabot obtained by S3 enters in drying box pressurizes, constant temperature-29 DEG C ~-23 DEG C constant temperature times 3 ~ 6 hours; Then 27 DEG C are gradually warming up to, heating-up time 1 ~ 2h;
S5: secondary temperature elevation, and keep 50 DEG C ~ 60 DEG C to heat after the scheduled times, pulverizes with airslide disintegrating mill, gets collection material and obtains the passionfruit powder that moisture is less than 4.5%.
The fruit powder nutrition that passionfruit powder, preparation method thereof of the present invention obtains obtains intact reservation; Can be long time stored under normal temperature, and do not need dextrin and any anticorrisive agent; Lightweight, be easy to carry about with one and transport; Range of application is wider, and easy to use.
Composition of the present invention is selected in natural plant material has certain sleeping, the medicinal material of calming the nerves or plant, and coordinate modern study to find to have the synergistic monomer component of improving water flood quality, prescription ratio is safe and effective, has no side effect.
Passionflower is commonly called as passion fruit, containing more than 130 kinds of aromatic substances.Not only sweet acid is good to eat, nutritious, balanced for it, and is very easy to digested, is desirable natural green food.Passionflower contains the multivitamin such as vitamin A, B race, C, D, E; Also containing various trace elements such as calcium, phosphorus, iron, manganese, copper, sodium, phosphorus, magnesium, zinc and potassium; In addition, passionflower is also containing unrighted acid and amino acid, and wherein amino acid contained kind is very abundant, has tryptophan, leucine, proline, threonine, lysine and phenylamino acid etc., therefore enjoys the good reputation of " king of fruit juice " and " spices fruit ".Its character is gentle, pressure of can releiving, anxiety reduction sense, has complicated effect to central nervous system.Can make neural comprehensively stable, make you have a good sleep, there is the function of anxiety and tense of releiving, depressed joyless, the nervous headache caused, have auxiliary therapeutic action to diseases such as neurasthenia.In addition, the distinctive fragranced of passionflower can make people happy, thus plays psychotherapy effect.
The diseases such as in composition, spina date seed has tonifying liver, Ning Xin, arrest sweating, the function of promoting the production of body fluid, and the traditional Chinese medical science is used for restlessness of asrhenia type and insomnia, palpitation with fear dreaminess.Flos Albiziae taste is sweet, and property is put down, and has aromatic odor, and the effect that Xie Yu allays excitement is better, controls depressed egersis, excited uneasy.The insomnia that Polygonum multiflower knotweed cures mainly the deficiency of blood and causes, neurasthenia and anaemia and have above-mentioned card shape person all available, dreaminess and Yi Jingzhe use more suitable.Polygonum multiflower knotweed, Flos Albiziae and the spina date seed three organ function focused on from human body of arranging in pairs or groups regulates, and reaching relaxes sleeps effect of slow pressure.In prescription, the kind enriching yin of enriching blood of mulberry fruit, promotes the production of body fluid and moisturizes, can be used for dizzy tinnitus, palpitation and insomnia.
γ-aminobutyric acid in composition, glycine, L-tryptophan, vitamin B6 all has and certain helps sleep effect.This three seed amino acids constituents all belongs to the composition acting on neurotransmitter, the axoneuron of about 40% may using GABA as inhibitory neurotransmitter, can be fundamentally calm neural, central nervous system can be suppressed to be overexcited, to brain, there is stable effect, and then promote loosen and allay nervousness.GABA can improve the activity of glucose phosphatidase in brain, effectively can activate brain blood flow and lead to; Increase oxygen supply amount etc.Glycine is inhibitory neurotransmitter, and L-Trp is as sedative, and have and regulate the spiritual rhythm and pace of moving things, improving water flood, two seed amino acids are called " amino acid of sleeping soundly " by people.Vitamin B6 then participates in some neurohumoral synthesis, is the normal necessary material of brain function, is also a kind of antitonic vitamin.
Adopt integration of drinking and medicinal herbs natural food materials and safely and effectively functional monomer composition carry out compatibility, each component is acted synergistically, effectively can help the effect of releasing the pressure by improving water flood, it is little that nervous centralis in hinge structure suppresses class medicine to compare side effect, has no adverse reaction and taste sour and sweet palatability and local flavor is splendid.
As preferred version of the present invention: described composition comprises the raw material of following weight portion: 9 parts, passionfruit powder, spina date seed 4 parts, Flos Albiziae 2 parts, Polygonum multiflower knotweed 8 parts, GABA (GABA) 0.2 part, glycine 0.08 part, L-Trp 0.02 part, vitamin B6 0.00010 part, Sucralose 0.015 part.
Described Polygonum multiflower knotweed is obtained by following steps: first use 10 times of poach 60 minutes, and after filtering, its slag adds 8 times of poach 40 minutes again, and after filtered fluid merges, concentrated spray is drying to obtain.
Described preparation comprises above-mentioned composition and pharmaceutically acceptable auxiliary material.
Beneficial effect of the present invention:
Adopt integration of drinking and medicinal herbs natural food materials and safely and effectively functional monomer composition carry out compatibility, each component is acted synergistically, effectively can help the effect of releasing the pressure by improving water flood, it is little that nervous centralis in hinge structure suppresses class medicine to compare side effect, has no adverse reaction and taste sour and sweet palatability and local flavor is splendid.
Detailed description of the invention
Embodiment 1:
Passionfruit powder of the present invention has following steps to obtain:
S1: the passionflower fresh fruit of cleaning is shelled, remove seed after making beating obtain containing soluble solid be 10 ~ 12 ° of Bx, total acid content is 3 ~ 5%, pH value be 3.0 ± 0.5 passionflower magma for subsequent use;
S2: the passionflower magma freeze concentration obtained by S1 obtains containing the dense sauce of passionflower that soluble solid is 40 ~ 60 ° of Bx;
S3: it is freezing that the dense sauce of the passionflower obtained by S2 is placed in the temperature of-50 DEG C ~-60 DEG C, enters crusher in crushing and obtains the particle that diameter is less than 3mm after the dense sauce of whole passionflower freezes;
S4: the particle sabot obtained by S3 enters in drying box pressurizes, constant temperature-29 DEG C ~-23 DEG C constant temperature times 3 ~ 6 hours; Then 27 DEG C are gradually warming up to, heating-up time 1 ~ 2h;
S5: secondary temperature elevation, and keep 50 DEG C ~ 60 DEG C to heat after the scheduled times, pulverizes with airslide disintegrating mill, gets collection material and obtains the passionfruit powder that moisture is less than 4.5%.
There is the composition that improving water flood helps to release the pressure, 7 parts, the passionfruit powder obtained by above-mentioned steps, spina date seed 3 parts, Flos Albiziae 1 part, Polygonum multiflower knotweed 6 parts, GABA (GABA) 0.1 part, glycine 0.05 part, L-Trp 0.01 part, Cobastab
60.00007 part, Sucralose 0.01 part.The water boil that spina date seed, Flos Albiziae, Polygonum multiflower knotweed add 10 times amount for the first time extracts 60 minutes, the water boil that second time adds 8 times amount extracts 40 minutes, extracted twice liquid filters after merging, 100 mesh sieves are crossed through concentrating and making extract after drying, namely auxiliary material pharmaceutically acceptable with other can be made into the preparation having improving water flood and help to release the pressure after mixing again, can join in food or health products.
Embodiment 2:
There is the composition that improving water flood helps to release the pressure, 9 parts, the passionfruit powder obtained by embodiment 1, spina date seed 5 parts, Flos Albiziae 3 parts, Polygonum multiflower knotweed 10 parts, γ-aminobutyric acid (GABA) 0.5 part, glycine 0.1 part, L-tryptophan 0.05 part, Cobastab
60.00022 part, Sucralose 0.02 part composition.The water boil that spina date seed, Flos Albiziae, Polygonum multiflower knotweed add 10 times amount for the first time extracts 60 minutes, the water boil that second time adds 8 times amount extracts 40 minutes, extracted twice liquid filters after merging, 100 mesh sieves are crossed through concentrating and making extract after drying, namely auxiliary material pharmaceutically acceptable with other can be made into the preparation having improving water flood and help to release the pressure after mixing again, can join in food or health products.
Embodiment 3:
There is the composition that improving water flood helps to release the pressure, 7 parts, the passionfruit powder obtained by embodiment 1, spina date seed 5 parts, Flos Albiziae 3 parts, Polygonum multiflower knotweed 10 parts, γ-aminobutyric acid (GABA) 0.5 part, glycine 0.1 part, L-tryptophan 0.05 part, Cobastab
60.00022 part, Sucralose 0.01 part composition.The water boil that spina date seed, Flos Albiziae, Polygonum multiflower knotweed add 10 times amount for the first time extracts 60 minutes, the water boil that second time adds 8 times amount extracts 40 minutes, extracted twice liquid filters after merging, 100 mesh sieves are crossed through concentrating and making extract after drying, namely auxiliary material pharmaceutically acceptable with other can be made into the preparation having improving water flood and help to release the pressure after mixing again, can join in food or health products.
Embodiment 4:
There is the composition that improving water flood helps to release the pressure, 9 parts, the passionfruit powder obtained by embodiment 1, spina date seed 3 parts, Flos Albiziae 1 part, Polygonum multiflower knotweed 6 parts, γ-aminobutyric acid (GABA) 0.1 part, glycine 0.05 part, L-tryptophan 0.01 part, Cobastab
60.00007 part, Sucralose 0.02 part composition.The water boil that spina date seed, Flos Albiziae, Polygonum multiflower knotweed add 10 times amount for the first time extracts 60 minutes, the water boil that second time adds 8 times amount extracts 40 minutes, extracted twice liquid filters after merging, 100 mesh sieves are crossed through concentrating and making extract after drying, namely auxiliary material pharmaceutically acceptable with other can be made into the preparation having improving water flood and help to release the pressure after mixing again, can join in food or health products.
animal experiment:
1. animal used as test: adult mice, single sex, 18-22 gram, is divided into 5 experimental group at random, often organizes 12.
2. dosage grouping and given the test agent give the time: 3 dosage groups and a positive controls are established in experiment, and press 10 times of human body recommended amounts for high dose group with the proportioning of example 1, separately establish two dosage groups, and establish positive controls, given the test agent gives 30 days time.
3. experimental technique extends the yellow Jackets test length of one's sleep: select injected in mice yellow Jackets, reach more than Nmin as sleep criterion using mouse righting reflex loss, observes the incubation period starting sleep to group mouse each after yellow Jackets.
4. principle: on the basis of yellow Jackets hypnosis, observes tested material and whether can extend the length of one's sleep, if the length of one's sleep extends, illustrate that tested material and yellow Jackets have synergy.
5. specific experiment method: positive gavage gives 550mg/kg, experimental group respectively gavage gives 400mg/kg, 650mg/kg and 900mg/kg.Amobarbital sodium water solution: precision takes yellow Jackets powder 500mg, and the constant volume that is dissolved in water is made to 100mL.After last sample administration 20min, each group mouse presses 50mg/kgBW dosage lumbar injection yellow Jackets, and injection volume is 0.2mL/20gBW.With the righting reflex loss of mouse for sleep judge index, observe the impact of mouse on the prolongation length of one's sleep of yellow Jackets inducing mouse.
Statistics carries out the experiment length of one's sleep of prolongation yellow Jackets, and result is as follows:
The animal efficacy test of the present composition
| Group | Quantity/only | The length of one's sleep/min | Rate elongation |
| Blank group | 12 | 32.1±6.5 | __ |
| Positive controls | 12 | 43.1±7.8 | 29.8 |
| By trial-production amount (low dosage) | 12 | 87.3±12.3 | 171.9 |
| By trial-production amount (low middle amount) | 12 | 117.4±8.6 | 265.7 |
| By trial-production amount (low a large amount) | 12 | 148.6±18.7 | 362.9 |
Result: the present composition can extend the length of one's sleep, shortens Sleep latency.
Duration of test, each treated animal vegetative activity is normal.Each dosage group mouse weekly body weight, food-intake, food utilization and off-test time each dosage group body weight, weight gain, total food-intake, total foodstuff utilization rate, dirty body compare than with control group, the equal not statistically significant of difference (P>0.05).Each dosage group glutamic-pyruvic transaminase, urea, middle dosage group glutamic-oxalacetic transaminease, blood sugar, red blood cell count(RBC) are compared with control group, difference has statistical significance (P<0.05), but all in this laboratory range of normal value, and abiology meaning is thought in this laboratory.The serum glutamic pyruvic transminase of all the other each dosage group mouse, glutamic-oxalacetic transaminease, urea, creatinine, blood sugar, T-CHOL, triglycerides, total protein, albumin measuring value, hemoglobin, red blood cell count(RBC), white blood cell count(WBC) and the equal not statistically significant of leukocyte differential count difference compared with control group (P>0.05).Make histopathological examination to by inspection internal organs, have no specific lesions.
Above-listed detailed description is illustrating for possible embodiments of the present invention, and this embodiment is also not used to limit the scope of the claims of the present invention, and the equivalence that all the present invention of disengaging do is implemented or changed, and all should be contained in the scope of the claims of this case.
Claims (4)
1. the composition that there is improving water flood and help to release the pressure, it is characterized in that, described composition comprises the raw material of following weight portion: passionfruit powder 7-9 part, spina date seed 5-3 part, Flos Albiziae 3-1 part, Polygonum multiflower knotweed 10-6 part, GABA (GABA) 0.1-0.5 part, glycine 0.05-0.1 part, L-Trp 0.01-0.05 part, vitamin B6 0.00007-0.00022 part, Sucralose 0.01-0.02 part;
This passionfruit powder is obtained by following steps:
S1: the passionflower fresh fruit of cleaning is shelled, remove seed after making beating obtain containing soluble solid be 10 ~ 12 ° of Bx, total acid content is 3 ~ 5%, pH value be 3.0 ± 0.5 passionflower magma for subsequent use;
S2: the passionflower magma freeze concentration obtained by S1 obtains containing the dense sauce of passionflower that soluble solid is 40 ~ 60 ° of Bx;
S3: it is freezing that the dense sauce of the passionflower obtained by S2 is placed in the temperature of-50 DEG C ~-60 DEG C, enters crusher in crushing and obtains the particle that diameter is less than 3mm after the dense sauce of whole passionflower freezes;
S4: the particle sabot obtained by S3 enters in drying box pressurizes, constant temperature-29 DEG C ~-23 DEG C constant temperature times 3 ~ 6 hours; Then 27 DEG C are gradually warming up to, heating-up time 1 ~ 2h;
S5: secondary temperature elevation, and keep 50 DEG C ~ 60 DEG C to heat after the scheduled times, pulverizes with airslide disintegrating mill, gets collection material and obtains the passionfruit powder that moisture is less than 4.5%.
2. a kind of composition that there is improving water flood and help to release the pressure according to claim 1, it is characterized in that, described composition comprises the raw material of following weight portion: 9 parts, passionfruit powder, spina date seed 4 parts, Flos Albiziae 2 parts, Polygonum multiflower knotweed 8 parts, GABA (GABA) 0.2 part, glycine 0.08 part, L-Trp 0.02 part, Cobastab
60.00010 part, Sucralose 0.015 part.
3. a kind of composition that there is improving water flood and help to release the pressure according to claim 1, it is characterized in that, described Polygonum multiflower knotweed is obtained by following steps: first use 10 times of poach 60 minutes, and after filtering, its slag adds 8 times of poach 40 minutes again, and after filtered fluid merges, concentrated spray is drying to obtain.
4. have the preparation that improving water flood helps to release the pressure, it is characterized in that, described preparation comprises composition described in claim 1 or 2 and pharmaceutically acceptable auxiliary material.
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| CN111265541A (en) * | 2020-03-22 | 2020-06-12 | 北京泰克美高新技术有限公司 | Liquid preparation health-care product for improving insomnia and relieving pressure |
| CN113040393A (en) * | 2021-03-31 | 2021-06-29 | 杨继辉 | Nutritional formula for intervening anxiety and sleep disorder |
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Application publication date: 20151007 |