CN104884457A - 吡唑并嘧啶酮类或吡咯并三嗪酮类衍生物、其制备方法及其在医药上的应用 - Google Patents
吡唑并嘧啶酮类或吡咯并三嗪酮类衍生物、其制备方法及其在医药上的应用 Download PDFInfo
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- CN104884457A CN104884457A CN201480003662.2A CN201480003662A CN104884457A CN 104884457 A CN104884457 A CN 104884457A CN 201480003662 A CN201480003662 A CN 201480003662A CN 104884457 A CN104884457 A CN 104884457A
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Abstract
本发明提供了吡唑并嘧啶酮类或吡咯并三嗪酮类衍生物，其制备方法及其在医药上的应用。具体而言，本发明涉及一种通式(I)所示的吡唑并嘧啶酮类或吡咯并三嗪酮类衍生物及其可药用盐，其制备方法以及它们作为促性腺素释放激素(GnRH)受体拮抗剂特别是作为子宫内膜异位症等治疗剂的用途，其中通式(I)中的各取代基的定义与说明书中的定义相同。
Description
PCT国内申请，说明书已公开。
Claims (24)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201480003662.2A CN104884457B (zh) | 2013-10-30 | 2014-09-30 | 吡唑并嘧啶酮类或吡咯并三嗪酮类衍生物、其制备方法及其在医药上的应用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310525956 | 2013-10-30 | ||
| CN2013105259569 | 2013-10-30 | ||
| CN201480003662.2A CN104884457B (zh) | 2013-10-30 | 2014-09-30 | 吡唑并嘧啶酮类或吡咯并三嗪酮类衍生物、其制备方法及其在医药上的应用 |
| PCT/CN2014/087906 WO2015062391A1 (zh) | 2013-10-30 | 2014-09-30 | 吡唑并嘧啶酮类或吡咯并三嗪酮类衍生物、其制备方法及其在医药上的应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104884457A true CN104884457A (zh) | 2015-09-02 |
| CN104884457B CN104884457B (zh) | 2016-12-07 |
Family
ID=53003302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201480003662.2A Active CN104884457B (zh) | 2013-10-30 | 2014-09-30 | 吡唑并嘧啶酮类或吡咯并三嗪酮类衍生物、其制备方法及其在医药上的应用 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US10005781B2 (zh) |
| EP (1) | EP3064498B1 (zh) |
| JP (1) | JP6412563B2 (zh) |
| CN (1) | CN104884457B (zh) |
| AU (1) | AU2014344504C1 (zh) |
| BR (1) | BR112016008799B1 (zh) |
| CA (1) | CA2927641C (zh) |
| CY (1) | CY1122196T1 (zh) |
| DK (1) | DK3064498T3 (zh) |
| ES (1) | ES2747839T3 (zh) |
| HR (1) | HRP20191679T1 (zh) |
| HU (1) | HUE046314T2 (zh) |
| LT (1) | LT3064498T (zh) |
| MX (1) | MX2016005142A (zh) |
| PL (1) | PL3064498T3 (zh) |
| PT (1) | PT3064498T (zh) |
| RS (1) | RS59457B1 (zh) |
| RU (1) | RU2674977C2 (zh) |
| SI (1) | SI3064498T1 (zh) |
| TW (1) | TWI675838B (zh) |
| WO (1) | WO2015062391A1 (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018086608A1 (zh) * | 2016-11-14 | 2018-05-17 | 江苏恒瑞医药股份有限公司 | 一种GnRH受体拮抗剂的结晶形式及其制备方法 |
| CN115141809A (zh) * | 2022-08-30 | 2022-10-04 | 南京诺唯赞生物科技股份有限公司 | 一种检测gnrh结合蛋白生物学活性的方法及试剂盒 |
| CN115260211A (zh) * | 2021-04-29 | 2022-11-01 | 长春金赛药业有限责任公司 | 含噻吩稠环类衍生物、药物组合物及其制备方法和应用 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016008799B1 (pt) * | 2013-10-30 | 2023-02-23 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Derivados de pirazolopirimidona ou pirrolotriazona, seus intermediários, seus usos, seus processos de preparação, e composição farmacêutica |
| CN108778280B (zh) * | 2016-11-07 | 2021-07-27 | 江苏恒瑞医药股份有限公司 | 一种GnRH受体拮抗剂的多晶型及其制备方法 |
| BR112020000725A2 (pt) | 2017-07-28 | 2020-07-14 | Jiangsu Hengrui Medicine Co., Ltd. | método para preparar derivado de heteroarila de pirimidona e intermediário de derivado de heteroarila de pirimidona |
| CN109970662B (zh) * | 2017-12-27 | 2023-06-30 | 上海科胜药物研发有限公司 | 一种制备噁拉戈利中间体的方法 |
| CN117203209A (zh) * | 2021-04-02 | 2023-12-08 | 江苏恒瑞医药股份有限公司 | 一种GnRH受体拮抗剂的结晶形式及其制备方法 |
| WO2023030293A1 (zh) * | 2021-08-30 | 2023-03-09 | 江苏恒瑞医药股份有限公司 | 一种GnRH受体拮抗剂的结晶工艺 |
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-
2014
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| WO2004014916A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
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