CN104873539A - Medicine for treating tinea corporis and cruris and preparation method of medicine - Google Patents
Medicine for treating tinea corporis and cruris and preparation method of medicine Download PDFInfo
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- CN104873539A CN104873539A CN201510276117.7A CN201510276117A CN104873539A CN 104873539 A CN104873539 A CN 104873539A CN 201510276117 A CN201510276117 A CN 201510276117A CN 104873539 A CN104873539 A CN 104873539A
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Abstract
The invention relates to a medicine for treating tinea corporis and cruris and a preparation method of the medicine, and belongs to the technical field of medicine preparation. The main technical characteristics are that the medicine consists of the raw materials of 100 g of salicylic acid powder, 100 g of chloramphenicol powder, 50 g of zinc oxide, 50 g of starch, 20 g of borneol and 250 g of vaseline. The medicine is prepared by pulverizing treatment, mixing treatment, paste making treatment and weighing. The principle of combining traditional Chinese medicines and Western medicines is adopted, the medicine has both traditional Chinese medicine raw materials and the Western medicine raw materials, makes good for deficiency, and is less in raw material component, simple in preparation method, convenient to use, non-irritant, painless, and less in toxic and side effects. 100 random sampling tinea corporis and cruris dermatosis clinical test examples prove that the cure rate is 83% or above, the total effective rate is 96% or above, the cure rate of the tinea corporis and cruris is obviously improved, and relapse can be avoided after curing.
Description
Technical field
The present invention relates to a kind of medicine and preparation method thereof, specifically a kind of medicine for the treatment of tinea corporis and cruris and preparation method thereof, belong to medicine manufacture technology field.
Background technology
Tinea corporis and cruris is a kind of difficult diseases, and it is a kind of commonly encountered diseases caused by heredity, environment, life style and the combined effect of human body device matter, and its pathogeny is very complicated, does not also have now effective medicine and method thoroughly to cure, never recurs.The people suffering from tinea corporis and cruris has at present got more and more, and tinea corporis and cruris is a kind of skin diseases comparing refractory, position, the place morbidities such as the easiest face at human body of this disease, neck, waist, abdomen, trunk and extremity.Just started as pimple or phlysis, and gradually towards periphery expansion spread, morbidity after the conscious pruritus of skin unbearably, acutely scratch easily cause local secondary bacterial infection or pachyderma coarse.Tinea corporis and cruris appears at skin surface, if Dermal exposure outside, can not cure for a long time, and patient can be caused to occur obstacle at heart, adds patient's burden at heart, and patient's Abwehrkraft des Koepers is reduced, totally unfavorable to treatment tinea corporis and cruris.
Tinea corporis and cruris is mostly caused by self other tinea, therefore will treat the tinea at other positions while treatment tinea corporis and cruris, as tinea capitis, the tinea manuum, tinea pedis etc.The human or animal suffering from tinea with other also should be avoided to contact, even if otherwise treatment got well tinea corporis and cruris and also can recur because of fungal infection again.
Tinea corporis and cruris is fungus-caused, and hormone can not killing fungus, can promote its Growth and reproduction on the contrary, tinea is developed sooner, more serious.So medicine for external use can not arbitrarily be abused.
At present, the medicine for the treatment of tinea corporis and cruris mainly contains Pevisone (compound econazole cream), WUJI GAO, daktarin, griseofulvin, ketoconazole etc., the skin mixed infection of these medicine primary treatments caused by fungus, antibacterial.But these ingredients are many, preparation technology is very complicated, and treatment tinea corporis and cruris has certain toxic and side effects, and some medicine is also containing hormone composition, and these medicines cure rear easily recurrence to tinea corporis and cruris, can not effect a radical cure tinea corporis and cruris.
Tinea corporis and cruris shows on skin, in fact the fungus and bacterium of tinea corporis and cruris is caused also to exist in a large number in blood samples of patients, if oral medicine tinea corporis and cruris erythra must be coordinated widely distributed when tinea corporis and cruris is in a bad way, antifungal agent for oral administration can be coordinated except application external medicine, conventional as griseofulvin, ketoconazole etc.But these medicines have certain side effect, larger to hepatorenal damage.
Summary of the invention
The object of the invention is the medicine easily recurrence after tinea corporis and cruris is cured in order to solve existing external curing tinea corporis and cruris, can not effect a radical cure tinea corporis and cruris, endo-medicine toxic and side effects is large, and has infringement to Liver and kidney, thus provides a kind of new technical scheme.
In order to achieve the above object, the present invention realizes by following technical scheme:
Treat a medicine for tinea corporis and cruris, it is the unguentum be made up of the raw material of following weight proportion:
Salicylic acid 100g, chlormycetin powder 100g, zinc oxide 50g, sodium bicarbonate 100g,
Starch 50g, Borneolum Syntheticum 20g, vaseline 250g.
Treat a preparation method for the medicine of tinea corporis and cruris, its preparation method and step are:
(1) pulverization process, mix homogeneously after salicylic acid and borneol and grinding, crosses 100 mesh sieves for subsequent use, obtains mixing fine powders A, for subsequent use;
(2) mixed processing, chlormycetin powder, zinc oxide, sodium bicarbonate, starch mix, and stir, and cross 100 mesh sieves, obtain mixing fine powders B, for subsequent use;
(3) cream process processed, adds gained mixing fine powders A in step (1) in step (2) mixing fine powders B and stirs, then adds vaseline and make unguentum;
(4) weigh, with balance, every bottle of Packing Unit is 25g.
The present invention is externally used paste.
Name of product of the present invention is " skin is healthy and free from worry ".
The present invention is compared with prior art advantageously: have raw material of Chinese medicine and Western medicine raw material, mutually learn from other's strong points to offset one's weaknesses, Chinese medicine and Western medicine combine, have and use raw material few, preparation method is simple, evident in efficacy, cure rate is high, sterilizes wide, and use procedure is non-stimulated, without pain.
Detailed description of the invention
Now in conjunction with specific embodiments the present invention is described in further detail:
Treat a medicine for tinea corporis and cruris, it is the unguentum be made up of the raw material of following weight in grams proportioning:
Salicylic acid 100g, chlormycetin powder 100g, zinc oxide 50g, sodium bicarbonate 100g,
Starch 50g, Borneolum Syntheticum 20g, vaseline 250g.
Treat a preparation method for the medicine of tinea corporis and cruris, its preparation method and step are:
(1) pulverization process, mix homogeneously after salicylic acid and borneol and grinding, crosses 100 mesh sieves for subsequent use, obtains mixing fine powders A, for subsequent use;
(2) mixed processing, chlormycetin powder, zinc oxide, sodium bicarbonate, starch mix, and stir, and cross 100 mesh sieves, obtain mixing fine powders B, for subsequent use;
(3) cream process processed, adds gained mixing fine powders A in step (1) in step (2) mixing fine powders B and stirs, then adds vaseline and make unguentum;
(4) weigh, with balance, every bottle of Packing Unit is 25g.
The product that the present invention obtains directly can be coated with unconcerned in focus affected part during use, according to state of an illness weight every day 2 ~ 6 times.
Pharmacodynamic study.
Salicylic acid: the effect with sterilization, parasite killing, antibacterial, sterilization, dissolves cutin, the Growth and reproduction of Antifungi and other antibacterial.
Chlormycetin powder: belong to broad spectrum antibiotic, all have inhibitory action to gram positive bacteria and negative bacterium and Li Kecishiization bacterium etc., the clinical infection with anti-various bacteria and fungus, because its toxicity is larger, can the diseases such as aplastic anemia be caused, how not advocate to take orally clinically.The present invention uses it for one for the treatment of tinea corporis and cruris medicine for external use raw material, and the just in time Yang Qi chief, keeps away its shortage, can give full play to its drug action, by clinical experiment, and therapeutic effect highly significant.
Zinc oxide: there is dampness removing to stop itchin, the effects such as convergence, anticorrosion, diaphoresis.
Sodium bicarbonate: belonging to antacid, is alkalescence, is used for the gastroenteropathys etc. such as the dyspepsia that hyperchlorhydria, acid regurgitation etc. cause clinically, can in and gastric acid and gastric lavage etc.
Borneolum Syntheticum: this product is pungent in flavor and cool in property, is slightly cold, and be apt to away leap up, clearance is had one's ideas straightened out, depressed pathogenic fire, reducing swelling and alleviating pain, hard masses softening and resolving, heat radiation, reduces focus local temperature, makes antibacterial and virus lose the hotbed of growth and breeding.
Starch: be foodstuff, belongs to integration of edible and medicinal herbs raw material, and food and pharmaceutical industry be unable to do without it.Starch performance is stablized, and without strong chemical reaction, is the optimal additive of pharmacy and food processing, and its maximum feature is exactly that precipitability is good.Several drugs molecule in this prescription can draw and sinks to focus basilar part by starch, give full play to the effect of other composition, the rubbish of affected area and toxin are excreted with the form of incrustation under the sporadic of Borneolum Syntheticum with the effect walking altering property, this is the synergism of starch.
Vaseline: belong to neutral adhesive, can moisturize by skin moistening, and be desirable substrate of making up a prescription, multi-medicament compatibility all selects vaseline as excipient substrate clinically.
Clinical experiment:
Criterion of therapeutical effect:
Recovery from illness: subjective symptoms disappears completely, dissipates, within 3 years, has no recurrence.
Subjective symptoms disappears, and dissipates, but there is tenderness local, follows up a case by regular visits to 1 year stable disease.
Subjective symptoms disappears substantially, and focus reduces more than 2/3, and within 1 year, the state of an illness is basicly stable.
Invalid: without significant change or aggravation person before and after treatment.
Analysis of age:
The clinical practice time, from 1975 ~ 2013, extracts 100 parts of case histories out at random in a large amount of case histories, patient's M-F and age composition as follows:
In tinea corporis and cruris 100 example, women 33 example, accounts for 33% of sum, and male 67 example, accounts for 67% of sum.M-F is 67 to 33; Minimum 11 years old of age, maximum 62 years old.11 years old-19 years old 3 people (accounting for 3%); 20 years old-30 years old 47 people (accounting for 47%); 31 years old-40 years old 28 people (accounting for 28%); 41 years old-50 years old 11 people (accounting for 11%); More than 51 years old 11 people (accounting for 11%).
Clinical trial results: in table 1
Table 1 tinea corporis and cruris dermatosis stochastic sampling cure rate statistical table
Experiment proves: the present invention is evident in efficacy in treatment tinea corporis and cruris, instant effect, and cure rate is high, non-stimulated, without pain, not easily recur after healing, tests cure rate reach more than 83% by clinical stochastic sampling.Also there is certain therapeutical effect to allergic dermatitis, acne, suppurative otitis media, eczema and pruritus vulvae.
Claims (2)
1. treat a medicine for tinea corporis and cruris, it is characterized in that it is the unguentum be made up of the raw material of following weight proportion:
Salicylic acid 100g, chlormycetin powder 100g, zinc oxide 50g, sodium bicarbonate 100g,
Starch 50g, Borneolum Syntheticum 20g, vaseline 250g.
2. treat a preparation method for the medicine of tinea corporis and cruris, it is characterized in that its preparation method and step are:
(1) pulverization process, mix homogeneously after salicylic acid and borneol and grinding, crosses 100 mesh sieves for subsequent use, obtains mixing fine powders A, for subsequent use;
(2) mixed processing, chlormycetin powder, zinc oxide, sodium bicarbonate, starch mix, and stir, and cross 100 mesh sieves, obtain mixing fine powders B, for subsequent use;
(3) cream process processed, adds gained mixing fine powders A in step (1) in step (2) mixing fine powders B and stirs, then adds vaseline and make unguentum;
(4) weigh, with balance, every bottle of Packing Unit is 25g.
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102008586A (en) * | 2009-09-08 | 2011-04-13 | 刘学忠 | Effective drug for treating skin disease |
CN103386058A (en) * | 2013-07-02 | 2013-11-13 | 袁娟 | Medicament for treating tinea cruris and preparation method |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102008586A (en) * | 2009-09-08 | 2011-04-13 | 刘学忠 | Effective drug for treating skin disease |
CN103386058A (en) * | 2013-07-02 | 2013-11-13 | 袁娟 | Medicament for treating tinea cruris and preparation method |
Non-Patent Citations (4)
Title |
---|
吴耀春、吴峻峰: "治头癣体癣股癣验方", 《中国民间疗法》 * |
张金华: "氯锌糊剂合清暑汤治疗黄水疮67例", 《山东中医杂志》 * |
李容、王柏桉: "复方水杨酸搽剂的制备与质量控制", 《中国药业》 * |
陈新谦主编: "《新编药物学 第十版》", 31 March 1978, 人民卫生出版社 * |
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Application publication date: 20150902 |