CN104857413A - Traditional Chinese medicine composition removing oral malodor and preparation method therefor - Google Patents
Traditional Chinese medicine composition removing oral malodor and preparation method therefor Download PDFInfo
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- CN104857413A CN104857413A CN201410359385.0A CN201410359385A CN104857413A CN 104857413 A CN104857413 A CN 104857413A CN 201410359385 A CN201410359385 A CN 201410359385A CN 104857413 A CN104857413 A CN 104857413A
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Abstract
The invention discloses a traditional Chinese medicine composition removing oral malodor and a preparation method therefor. The traditional Chinese medicine composition comprises the following raw materials: eupatorium, clove, fructus amomi and mint. The traditional Chinese medicine composition can be prepared into any common oral administration dosage form or health product, and has functions of clearing heat and fire, smoothing circulation, resolving dampness and expelling turbid. The plurality of traditional Chinese medicines cooperate with each other, and mutual cooperation synergy of the active ingredients removes oral malodor effectively. The composition has functions of sterilization and oral health care, and eliminates oral malodor caused by various factors rapidly. Oral breath is fresh and lasting after the composition is used. The composition has substantial curative effects of removing oral malodor, has no toxic or side effects, and can be taken for a long time.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, particularly a kind of Chinese medicine composition removing halitosis and preparation method thereof, belong to field of medicaments.
Background technology
Halitosis is frequent produced problem in mankind's daily life, it is the unpleasant implication making others be sick of, make oneself embarrassment come out from human mouth, puzzlement can be produced to mankind's communication activity, drastically influence the social activity of people, daily life, work, commercial interest and inter personal contact, halitosis is reported as a kind of disease by WHO.Investigation display, Chinese halitosis prevalence is 27.5%.And in western countries, be then 50%.The whole world about has the people of 10% ~ 65% once to suffer from halitosis.
Do not look down upon this slight defect of halitosis, it can make people's (especially youngster) closely dare not associate with people, thus produces inferiority complex, and impact interpersonal, affective interaction normally, makes us very worried.Some people, halitosis is heavier, and the implication oneself just can smelling oneself is smelly dirty; And some people, by his person's development, just know oneself halitosis.The method of implication of testing oneself: left and right two palm is closed up and harvest close bowl-shape, encase mouth and nose place, then exhale without a break in the two palms gathered and and then use snuffing gas, how just can smell abnormal smells from the patient in oneself mouth.
Cause the reason of problem of bad breath to have a lot, be divided into pathologic halitosis and physiological halitosis, be not the cause of not brushing teeth for a long time, have the abnormal flavour that dietary habit causes, also have the abnormal flavour that disease causes.Halitosis mainly like to eat cold drink, stomach function be stranded by cold-evil, the result of the high Sheng of positive bright dryness-fire.Most halitosis is relevant with the ecological environment in oral disease and oral cavity.Oral cavity is unclean, the accumulation of bacterial plaque, tartar, tartar causes the most direct reason of halitosis.Suffer from the patient of chronic gingivitis and periodontitis, due to swelling and aching of gum, hemorrhage, purulent discharge of pocket, dental health are very poor, and the bacterial plaque that tooth is piled up, tartar and tartar are under the effect of antibacterial and microorganism, and corruption fermentation, produces niff.Suffer from the patient of necrotic gingivitis, malignant tumor and postextraction infection, due to slough decompose suppurate after produce that earthworm is made an uproar, sulfydryl and limb class, so corruptibility halitosis can be had.In addition, exist in oral cavity and do not have the dental caries, residual crown and root, ill fitting prosthesis etc. for the treatment of all easily to accumulate food debris and dirt, produce a kind of unpleasant halitosis.
In order to the needs of satisfied social activity, the people being subject to halitosis puzzlement generally can find medicine and help, but due to the complexity of oral environment, there is the situation of incorrect use and Drug abuse, usually cause halitosis recurrent exerbation; And ingredient easily enters human body by oral cavity, harm is produced to body; Some people can cover halitosis by using chewing gum, alcoholic collutory or flavorants etc.Common chewing gum contains sugar and plasticizer, unhealthful; The taste of alcohol type collutory is choked people, and large to oral cavity irritation on mucous membrane, life-time service can change oral environment, and a lot of people represents that cannot stand collutory is unwilling to the stimulation in oral cavity to use collutory.And the poor durability of the product of existing removal halitosis, cannot keep pure and fresh effect for a long time.
Prove according to a large amount of census of population, there are the teenager of more than 3%, the person in middle and old age of more than 6%, because digestive system disease and oral disease cause long-term or interim halitosis, strange taste, sizable crowd is had because of individual or regional dietary habit with fashion, as peppery in raw meat (seafood) (rareripe, Rhizoma Zingiberis Recens) cigarette, wine etc., often suffer the puzzlement of halitosis, to the life of people, work brings many worries with exchanging.Product sold mainly covers halitosis with the chewing gum etc. of refrigerant sweet fragrance in the market, but the halitosis that this series products often causes gastrointestinal and oral disease and the strong food of taste of diet, as seafood, Herba Alii fistulosi, Bulbus Alliis etc. cover effect and not obvious, and also do not have help to oral cavity and dental health.
Summary of the invention
Primary and foremost purpose of the present invention provides a kind of Chinese medicine composition removing halitosis and preparation method thereof for the problems referred to above, compositions of the present invention is for the pathogenesis etiology of human body, halitosis, employing plurality of Chinese cooperatively interacts, the mutual Synergistic of its active component, effectively remove halitosis, the present composition has the effect of sterilization, oral cavity health, to removing the evident in efficacy of halitosis, the halitosis that rapid elimination various factors causes, without any side effects, and after using, oral cavity halitosis is lastingly pure and fresh.
For realizing object of the present invention, one aspect of the present invention provides a kind of Chinese medicine composition removing halitosis, comprises following raw material: Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae.
Wherein, the weight of the crude drug of the Chinese medicine composition of described removal halitosis is: Herba Eupatorii 2-15, Flos Caryophylli 1-10, Fructus Amomi 1-12, Herba Menthae 1-5.
Particularly, the weight of described crude drug is preferably: Herba Eupatorii 4-10, Flos Caryophylli 3-7, Fructus Amomi 2-6, Herba Menthae 1-2.
Especially, the weight of described crude drug is: Herba Eupatorii 4, Flos Caryophylli 4, Fructus Amomi 4, Herba Menthae 2.
The Chinese medicine composition of removal halitosis of the present invention fully realizes based on the traditional Chinese medical science, Chinese medicine the pathogenetic of human body, halitosis and halitosis and study, in conjunction with the achievement of modern pharmacy and pharmaceutical research, Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae is selected to carry out scientific composition and be prepared from, with the Chinese crude drug of pure natural for raw material, have no side effect, it is turbid that it is regulated the flow of vital energy by resolving heat and reducing pathogenic fire, fragrance, removing dampness is dispelled, and reaches the object removing human oral cavity abnormal flavour.
Wherein, Herba Eupatorii is the dry aerial parts of feverfew Herba Eupatorii Eupatorium fortunei Turcz..Property is put down, acrid in the mouth; Return spleen, stomach, lung meridian.Have removing dampness by means of aromatics, appetizing of being amusing, delivers effect of expelling summer-heat.Be mainly used in turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.(1) hygropyrexia disease key medicine is treated, the medicine fit applications such as normal and Herba Pogostemonis, Radix Scutellariae, Semen Coicis.In addition, the disease that sweet greasy sialism in damp-heat blocking in the body, mouth, implication are rancid is applicable to again.For interiorly to accumulate, fear of cold, heating, feeling of fullness in the head, the disease such as uncomfortable in chest, anorexia, often coordinate Herba Pogostemonis, Cortex Magnoliae Officinalis, Folium Nelumbinis with using.Containing euparin in Herba Eupatorii, Herba Eupatorii herb is containing volatilization Shan 1.5%-2.0%, and wherein main constituent is: cymol, acetic acid orange alcohol ester, flower alcohol ester, 5-methyl thymol ether, thymol methyl ether; Taraxasterol, taraxasterylacetate, taraxasterol cetylate, β-Amyrin ethanol, β-Amyrin cetylate, stigmasterol, cupreol, octacosanol, Palmic acid is contained in flower and leaf; Stem, leaf are containing Fumaric acid, succinic acid, mannitol; Aerial parts is containing the luxuriant and rich with fragrance alkali in Lip river, Ningde.
Modern pharmacological research shows 1) volatile oil of Herba Eupatorii popularity cold virus has inhibitory action; 2) Herba Eupatorii can cause cattle and sheep chronic poisoning, infringement kidney, liver and raw diabetes; 3) alcohol extract of fresh leaf or cured leaf contains a kind of toxic component, has acute toxicity, after rabbit administration, it can be made to anaesthetize, and even suppresses to breathe, and makes decreased heart rate, temperature decline, hyperglycemia and cause all diseases of glycosuria; 4) oral Herba Eupatorii can cause mice emotionally this time-outs all, and ovulation is suppressed; 5) Herba Eupatorii 100% water decoction, with tube dilution method, has inhibitory action to diphtheria corynebacterium, staphylococcus aureus, sarcina, Bacillus proteus, Bacillus typhi etc.Its volatile oil infected by influenza has inhibitory action.
Flos Caryophylli is dry flower, the fruit of plant clove of myrtaceae Eugenia caryophllata Thunb..Warm in nature, acrid in the mouth, returns spleen, stomach, lung, kidney channel.Have warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG, be mainly used in Deficiency and coldness of spleen and stomach, singultus is vomitted, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.Flos Caryophylli alabastrum (Flos Caryophylli), containing volatile oil (i.e. Oleum Caryophylli) 14 ~ 20%, contains eugenol 78 ~ 95%, aceteugenol about 3% and a small amount of Flos Caryophylli alkene, B-caryophyllene, MAK, the positive heptanone of methyl, vanillin, methyl salicylate, Humuleno, benzaldehyde, benzylalcohol, 3-Methoxybenzaldehyde, benzyl acetate, chavicol, a mono-ylangene etc. in oil; In addition, still containing oleanolic acid, tannin, fatty oil and cured.Fruit (Fructus Caryophylli) is containing volatile oil 2 ~ 9%.
Pharmacological research shows the ether leachate of Flos Caryophylli containing 1% concentration, and infusion or the Flos Caryophylli decoct containing 8% concentration all have inhibitory action to multiple pathogenic fungus bacillus, tubercule bacillus such as () such as Cryptococcus histolyticus, staphylococcus, streptococcus and diphtheria, distortion, green pus, large intestine, dysentery, typhoid fever; 100% ethanol Flos Caryophylli immersion is to bacillus pestis, vibrio cholera, anthrax bacillus, Bacillus typhi, diphtheria corynebacterium, Bacillus proteus, escherichia coli, bacillus subtilis and staphylococcus aureus inhibitory action; Oleum Caryophylli and eugenol are comparatively strong to the inhibitory action of Brucella, mycobacterium tuberculosis in vitro, have to common therapeutic dermatophytes the inhibitory action shown; Water or the alcohol extract of Flos Caryophylli have anthelmintic action; Flos Caryophylli is aromatic stomachic, has digestion promoting function, can alleviate abdominal bloating, strengthens digestion power, alleviate nausea and vomiting; Flos Caryophylli petroleum ether extract, lilac water extract have analgesic effect, all can dramatically to extend the mice pain sensation response latency and show to reduce mice because of glacial acetic acid and stimulate the writhing caused, reaction times; Oxygen remaining quantity in bottle when lilac water extract can extend the mouse survival time and reduce dead, illustrate that lilac water extract is not by the keto consumpting speed that slows down, but by improving mice oxygen Utilization ability under low oxygen conditions, the ability of anti-hypoxia under enhancing mice atmospheric closed; Flos Caryophylli hot water extract and water solublity component have the dual function of the inhibitory action of metabolism activation and the deactivation of metabolism activation Trp-p-2.
Fructus Amomi is the dry mature fruit of zingiberaceous plant Fructus Amomi Amomum villosum Lour., green shell sand Amomum villosumLour.var.xanthioides T.L.Wu et Senjen or SEMEN AMOMI LONGILIGULA Amomum longiligulareT.L.Wu.Warm in nature, acrid in the mouth, returns spleen, stomach, kidney channel.There is removing dampness appetizing, warming spleen and stopping diarrha, antiabortive effect of regulating the flow of vital energy.Be mainly used in turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.Fructus Amomi, kernel is containing volatile oil, and through qualification, composition has acetyl borneol ester, Camphora, limonene, lauro lene, α pinene, nopinene, Borneolum Syntheticum, beta-elemene, β-Flos Caryophylli alkene, β-bergmot oil alkene, α-thujene, myrcene, α-phellandrene, linalool, α-farnesene, β-farnesene, humulene, β-bisabolence, γ-cadinene, nearly 30 kinds of Palmic acid etc.Fruit contains various trace elements (ug/g): zinc, copper, ferrum, manganese, bores, chromium, molybdenum, nickel, titanium, vanadium; Though the volatile oil of leaf and each component content of Volatile Oil from Seed have difference, basis set one-tenth is substantially identical.
Pharmacological research shows that Fructus Amomi decoct can make Cavia porcellus, rat small intestine intestinal contraction is strengthened, and have inhibitory action to intestinal tube during escalated dose, performance tension force reduces, and amplitude reduces.The rat small intestine intestinal tube tonicity caused acetylcholine and barium chloride, tetanic contraction have partial inhibition.The volatility position of Fructus Amomi can make rabbit intestinal tube slightly excited, then proceeds to obvious inhibitory action, and tension force reduces, and contraction frequency slows down, and amplitude reduces, and with concentration is different can the partially or completely excited or spasm of the intestinal tube that causes of antagonism acetylcholine, BaCl2.Fructus Amomi can obvious anticoagulant.Fructus Amomi has obvious protective effect to the death of mice that arachidonic acid brings out.Fructus Amomi has the effect significantly resisting the death of mice of being brought out by collagen and epinephrine.
Herba Menthae is herb or the leaf of labiate Herba Menthae, is the dry aerial parts of Labiatae mint Herba Menthae Menthahaplocalyx Briq..Cool in nature, acrid in the mouth, returns lung, Liver Channel.There is dispelling wind-heat, refresh oneself, effect of rash.Be mainly used in anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast the side of body feeling of distension and oppression.The fresh leaf of Herba Menthae is containing stain 1%-1.46%, and in oil, main constituent is levorotatory menthol, content 62.3%-87.2%, also containing left-handed menthone, isomenthone, pulegone, decyl acetate, menthyl acetate, essence of Niobe, α-and nopinene, β-thujene, 3-amylalcohol, 2-is alcohol, 3-capryl alcohol, dextrorotation myrcene, limonene and cineole, alpha-terpineol etc.Again containing flavones ingredient: different Rui Fuling, luteolin-7-glycoside, Herba Menthae daidzin; Determination of Organic Acids: rosmarinic acid, caffeic acid; Chloro acid composition: aspartic acid, glutamic acid), serine, agedoite, valine, leucine and isoleucine, phenylalanine, methionine, lysine.Tool antiinflammatory action is the Multiple components of parent nucleus with dihydroxy-1,2-dihydronaphthalene dihydroxy acid: 1. 1-(3,4-dihydroxy phenyl)-6,7-dihydroxy-1,2-dihydronaphthalene-2,3 dihydroxy acid [1-(3,4-dihydroxyphenyl)-6,7-dihydroxy-1,2-dihy-dronaphthalene-2,3-dicarboxylic acid], 2. 1-(3,4-dihydroxy phenyl-1,2-dihydronaphthalene-2-hydroxy acid.
Herba Menthae has antivirus action: aqua methnae decoct 1:20 concentration, has inhibitory action to viral ECHO11 strain; Analgesia, itching-relieving action: Mentholum mainly makes external use anti pruritic, faint local anaesthesia and counteirritantia, be applied to local and cause cool feeling owing to exciting nerve, and suppress pain nerve; Irritation, antitussive action: the irritation effect of Mentholum causes trachea to produce new secretion, and make the mucus of stiff be easy to discharge, therefore have phlegm-dispelling functions, also there is report Mentholum to Cavia porcellus and have good antitussive action per capita; Bactericidal action: Mentholum has very strong bactericidal action, d-Mentholum is stronger than the bacteriostasis of 1-Mentholum; Anti-implantation, antiearly pregnancy effect: Oleum menthae has certain anti-implantation and antiearly pregnancy effect to white mice, and action intensity increases with dosage, only, anti-implantation rate reaches 100% to lumbar injection 0.035ml/.The reason of termination of pregnancy may be that uterine contraction is strengthened, and can not get rid of the coup injury of decidua tissue etc.In utero administration, Oleum menthae not only can make ovule seen by former pregnant 6th day downright bad, and can make it to excrete, and compared with Fructus Canarii albi line of oils, difference shows; Choleretic effect: acetone dry extract and the 50% methanol dry extract of Herba Menthae all have choleretic effect, and compared with matched group, choleresis all has obvious increase.Function of gallbladder promoting effect containing the many acetone dry extract group of volatile oil is stronger than 50% methanol dry extract group.Experiment proves, except main component menthol in volatile oil has except very strong choleretic effect, also containing other choleretic effect compositions in Oleum menthae.In addition, after the alcoholic extract hydroxyl group acetylation of menthol, its choleretic effect also reduces, and illustrates that alcoholic extract hydroxyl group plays an important role in the generation of choleretic effect.
The Chinese medicine composition of removal halitosis of the present invention (i.e. the pure and fresh happy fragrant liquid of book on Chinese herbal medicine) forms according to the function of above medicine and the special role compatibility of chemical composition, is that, removing dampness pyrolysis fire-toxin, anti-inflammation clear with Herba Eupatorii, Herba Menthae, aroma, removal oral cavity are old, abnormal flavour, halitosis, with Fructus Amomi, Flos Caryophylli fragrance is highly seasoned, strong spleen stomach invigorating, improve gastro-intestinal digestion and wriggling function, remove pneumatosis in digestive tube, full side's compatibility is respectively containing fragrant volatile oil, but effect has to have clearly falls, mutually collaborative, with Herba Eupatorii, Herba Menthae, refrigerant fragrance, except its oral cavity and surperficial abnormal flavour, again with Flos Caryophylli, Fructus Amomi, dense its gastrointestinal foul smell that disappears of fragrance, and due to it possess antibacterial, the effect of antiinflammatory and raising gastrointestinal function, so, to gastrointestinal, the oral diseases such as gingiva have good prevention and health-care effect, effective eliminating effect is fast had to the halitosis caused because of above-mentioned disease or diet, and fragrance is long.Crowd's experimentation according to the pure and fresh happy fragrant liquid of book on Chinese herbal medicine proves, not only drug treatment is short for this happy fragrant liquid, instant effect, and safe without toxic side effect.
The present invention provides a kind of preparation method removing the Chinese medicine composition of halitosis on the other hand, comprises the steps:
1) raw material is prepared according to following weight:
Herba Eupatorii 2-15, Flos Caryophylli 1-10, Fructus Amomi 1-12, Herba Menthae 1-5
2) by after Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae mix homogeneously, heating extraction is carried out to mixed material medicine, collect extracting solution;
3) concentration is carried out to the extracting solution collected, to obtain final product.
Wherein, step 1) described in crude drug weight be preferably: Herba Eupatorii 4-10, Flos Caryophylli 3-7, Fructus Amomi 2-6, Herba Menthae 1-2.
Particularly, the weight of described crude drug is preferably: Herba Eupatorii 4, Flos Caryophylli 4, Fructus Amomi 4, Herba Menthae 2.
Wherein, step 2) described in heating extraction comprise the step that following order carries out:
A) mixture of Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae is added water soaking, the weight of the water added is 6-15:1 with the ratio of the weight of mixture, soak 2-5 hour post-heating, be warming up to 100 DEG C, under maintenance temperature is the condition of 100 DEG C, extracts 10-20min;
B) mixture after heating is filtered, collect filtrate.
Particularly, steps A) described in heating extraction time 10-15min, the weight of the water added is preferably 8-12:1 with the ratio of the weight of mixture.
Especially, steps A) described in soak time be preferably 3-4 hour, more preferably 4 hours; The heating extraction time is preferably 15min.
Wherein, step 3) described in filtrate concentration process in control temperature be 80-100 DEG C, relative pressure is lower than-0.05MPa.
Particularly, described relative pressure is preferably-0.05 ~-0.1MPa, more preferably-0.05 ~-0.095MPa.
Described relative pressure is a kind of using atmospheric pressure as the pressure represented by benchmark, is the one of the method for expressing of pressure.Relative pressure=absolute pressure-atmospheric pressure.
Particularly, step 3) described in weight and the crude drug Herba Eupatorii of concentrated solution, Flos Caryophylli, Fructus Amomi and Herba Menthae the ratio of gross weight be 0.1-0.9:1, be preferably 0.1-0.3:1, more preferably 0.1:1.
Particularly, step 3) described in weight and the crude drug Herba Eupatorii of concentrated solution, Flos Caryophylli, Fructus Amomi and Herba Menthae the ratio of gross weight be 0.1-0.9:1, be preferably 0.5-0.9:1, more preferably 0.9:1.
Wherein, when the ratio of the gross weight of the weight of described concentrated solution and described crude drug Herba Eupatorii, Flos Caryophylli, Fructus Amomi and Herba Menthae is 0.5-0.9:1, in concentrated solution, add antiseptic, make and remove halitosis Chinese medicine composition solution, be i.e. the pure and fresh happy fragrant liquid of book on Chinese herbal medicine of the present invention.
Particularly, also comprise step 4) weight of described concentrated solution and described crude drug Herba Eupatorii, Flos Caryophylli, Fructus Amomi and Herba Menthae the ratio of gross weight when being 0.1-0.3:1, in the solution after concentrated, add acceptable adjuvant and antiseptic on pharmaceutics.
Wherein, described pharmaceutically acceptable adjuvant can (Handbook ofPharmaceutical excipients, be edited by A.Wade and P.J.Weller by the 2nd edition in " handbook of pharmaceutical excipients "; AmericanPharmaceutical Association publishes, Washington and The Pharmaceutical Press, London, 1994) etc. find in reference book.
Especially, described carrier comprises excipient, as starch, water etc.; Lubricant, as magnesium stearate etc.; Disintegrating agent, as microcrystalline Cellulose etc.; Filler, as lactose etc.; Binding agent, as pregelatinized Starch, dextrin etc.; Sweeting agent; Antioxidant; Antiseptic, correctives, spice etc.
Particularly, the consumption of described antiseptic is add antiseptic 0.5-0.05g in every 100g concentrated solution; The consumption of described adjuvant is add described adjuvant 10-50g in every 100g concentrated solution.
Particularly, described food preservative selects potassium sorbate, sodium diacetate, benzoic acid and salt thereof, calcium propionate, sodium lactate or dehydro sodium acetate.
Another aspect of the invention provides a kind of pharmaceutical preparation of the removal halitosis be made up of acceptable auxiliary material combination on above-mentioned arbitrary described Chinese medicine composition and pharmaceutics.
Wherein, pharmaceutical composition of the present invention can with acceptable adjuvant on pharmaceutics by tradition or the oral type of the clinical acceptable of modern production process processing procedure.As capsule, tablet, granule, pill, oral liquid etc.Excipient substance used can be starch, dextrin, lactose, microcrystalline cellulose, gelatin, sucrose, magnesium stearate etc.Need long-term prescription clinically, it is convenient to make solid preparation storage, and patient takes facility, also more meeting the market requirement.Preferred dosage form is capsule, granule, tablet.
Further aspect of the present invention provides a kind of above-mentioned arbitrary described Chinese medicine compositions to remove in the medicine of halitosis or health product in preparation and applies.
The present invention relates to that a kind of Chinese herbal medicine eliminates human body, the compositions of halitosis can be used for halitosis, abnormal flavour etc. that people cause because of gastrointestinal and oral disease and diet and eliminate effectively fast, simultaneously, the abnormal flavour in various living environment can also be widely used in, remove and can fragrance be retained, having no side effect.
Drug regimen of the present invention is that tool has the following advantages:
1, medicament composing prescription compatibility science of the present invention, determined curative effect, safety is high, quality controllable;
2, turbid effect that pharmaceutical composition of the present invention has resolving heat and reducing pathogenic fire, fragrance is regulated the flow of vital energy, removing dampness is dispelled, remove human body, halitosis evident in efficacy, the effect for the treatment of halitosis is obvious;
3, pharmaceutical composition action pathway of the present invention is many, and drug target is many, and mechanism of action is unique, the pathology link that medicine is fallen ill for critical body points's halitosis, medicine place to go halitosis evident in efficacy, effective percentage reaches 100%, and without repeatedly after treatment, without any side effects.
4, drug medication amount of the present invention is low, with low cost.
5, the present invention removes the process of preparing of the Chinese medicine composition of halitosis simply, constant product quality successful, and easy to use.
Detailed description of the invention
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include the pharmacodynamics test of medicine of the present invention.
Test example 1 bacteriostatic test
Filter paper enzyme is adopted to carry out bacteriostatic test.
1, test material
For examination strain: staphylococcus aureus (Staphylococcus aureus), Candida albicans (Moniliaalbican), all purchased from Products in China calibrating institute;
Nutrient agar (Beijing Baeyer enlightening biotech company provides);
2, test method
Pour in culture dish (diameter 90mm) after Nutrient agar is melted, shake up, cooled and solidified, for subsequent use;
Staphylococcus aureus, Candida albicans are used physiological saline solution suspendible respectively, makes staphylococcus aureus, Candida albicans bacteria suspension respectively;
Staphylococcus aureus, Candida albicans bacteria suspension are inoculated in the plane of nutrient agar panel by inoculation respectively, and inoculation evenly;
Then immerse in the pure and fresh happy fragrant liquid of book on Chinese herbal medicine of embodiment 1 preparation with the circular filter paper sheet that aseptic nipper tweezer is aseptic, filter paper is soaked, take out filter paper, when the drop of filter paper when vertically leaving standstill on it is not just dripped, filter paper is placed on the surface of nutrient agar panel being vaccinated with staphylococcus aureus, Candida albicans respectively, nutrient agar panel culture dish is placed in the incubator of 37 ± 2 DEG C, cultivates;
Cultivate after 24 hours, take out culture dish, measure the diameter of bacterial restrain, measure and average for 3 times.
3, result of the test
The average diameter of the bacterial restrain of staphylococcus aureus is 15.57mm; The average diameter of the bacterial restrain of Candida albicans is 14.49mm.
Result of the test shows that the Chinese medicine composition solution of removal halitosis of the present invention has obvious fungistatic effect.
Test example 2 removes halitosis clinical trial
1, object of study
Choose tested case 188 example of year July in April, 2012 to 2013 in Gate of Pervasive Peace Affiliated Hospital of Beijing University of Chinese Medicine, patient age 35-70 year, accept voluntarily to observe treatment, wherein male patient 108 example, female patient 80 example, the course of disease is the shortest 1 year, the longest 25 years.
A group: because gastrointestinal disease causes halitosis, halitosis, patient 97 example; B group: the halitosis that group causes because of oral diseases such as periodontitis, gingivitis, dental caries, halitosis patient 52 example; C group: the halitosis caused because of food, patient 39 example.
2, Therapeutic Method
Adopt the pure and fresh happy fragrant liquid of book on Chinese herbal medicine prepared by the embodiment of the present invention 1, every day 3 times, each 15ml, all after meal can buccal book on Chinese herbal medicine pure and fresh happy fragrant liquid 30-60 second, and other medicines of stopping using, observe 4 weeks cycles.
3.3 clinical efficacy criterion
Adopt 3 grade standards, effective: after using, oral cavity halitosis is pure and fresh immediately, no longer includes abnormal flavour, and under not having use to cause the prerequisite of the food of abnormal flavour, the breath freshening of more than 2 hours can be kept; Effective: after using, oral cavity halitosis is pure and fresh immediately, no longer includes abnormal flavour, and under not having use to cause the prerequisite of the food of abnormal flavour, the breath freshening of more than 1 hour can be kept; Invalid: after using symptom and sign not be improved significantly.
Test result is as shown in table 1.
The pure and fresh happy fragrant liquid of table 1 book on Chinese herbal medicine removes halitosis result
| A group | B group | C group | |
| Case load (example) | 97 | 52 | 39 |
| Effective (example) | 90 | 50 | 35 |
| Effectively (example) | 7 | 2 | 4 |
| Invalid (example) | 0 | 0 | 0 |
| Effective percentage (%) | 100 | 100 | 100 |
Result of the test shows:
1, the pure and fresh happy fragrant liquid of book on Chinese herbal medicine of the present invention can be the abnormal flavour that patient removes in oral cavity at short notice fast, and can keep breath freshening more than at least 2 hours.
Following up a case by regular visits to 2, through the later stage, uses the Chinese medicine composition more than one month of removal halitosis of the present invention continuously, and the later stage is the symptom finding that halitosis occurs.
Experimental result through one month shows that each group of 100% experimenter all represents that halitosis after the pure and fresh happy fragrant liquid of this book on Chinese herbal medicine of buccal, halitosis all disappeared in 1 minute, and light fragrance can be left for a long time in oral cavity, more than 90% is reduced to the relapse rate of oral disease simultaneously, more than 45% is reduced to the relapse rate of gastrointestinal dyspepsia disease, effectively reaches that to remove oral cavity different and have the object of health care.
The pure and fresh happy fragrant liquid of book on Chinese herbal medicine, prove according to a large amount of experiments, its function not only can alleviate the oral cavity of people and the abnormal flavour of health aspect efficiently and effectively, can also be widely used in easily producing in living strange taste, the environment of abnormal flavour and implements, as kitchen simultaneously, toilet, hotel, the abnormal flavour of the various aspects such as restaurant is removed and sterilization, and effectively, safety, has no side effect.
Test example 3 removes halitosis endurancing
Choose the patient 40 with the halitosis example of year August in April, 2013 to 2013 in the treatment of Gate of Pervasive Peace Affiliated Hospital of Beijing University of Chinese Medicine, use the pure and fresh happy scented tea of book on Chinese herbal medicine prepared by the embodiment of the present invention 4, the pure and fresh happy scented tea of every book on Chinese herbal medicine of buccal per capita, each 1, the oral cavity buccal time is about 1-5min;
Invite 10 people to evaluate the implication after the pure and fresh happy scented tea of patient's buccal book on Chinese herbal medicine in addition, think that halitosis eliminates 1 point, that thinks that halitosis do not eliminate must 0 point.Appraisal result be more than 6 points show that halitosis is eliminated, appraisal result lower than 6 points show that halitosis is not eliminated.
Every 1 hour, test result is once marked, test the pure and fresh happy scented tea of book on Chinese herbal medicine of the present invention and remove halitosis persistency.
Result of the test shows:
1, mark immediately after using the pure and fresh happy scented tea of book on Chinese herbal medicine of the present invention, the score of 40 routine patients is 10 points, shows that patient's halitosis is eliminated;
2, after the pure and fresh happy scented tea of test group buccal the present invention book on Chinese herbal medicine the 5th hour, just there is dividing equally result lower than the patient of 6 points in first time;
3, above-mentioned result of the test shows that the Chinese medicine composition of removal halitosis of the present invention can keep breath freshening more than 4 hours, and the effect of the Chinese medicine composition removal halitosis of removal halitosis of the present invention is lasting.
Test example 4 the present invention removes halitosis Chinese medicine composition toxicological test
(1) acute toxicity test
The Chinese medicine composition pill of removal halitosis of the present invention is gavaged 1000g (crude drug)/kg to kunming mice.There is not any toxic reaction, without animal dead in one week.
(2) long term toxicity test
The Chinese medicine composition pill of removal halitosis of the present invention is carried out long term toxicity test to rat, continuous heavy dose (100 times of adult human dose) gastric infusion, administration time long (90 days), with the general performance before and after animals administer, body weight, food ration, hematology and Biochemical Indices In Serum, routine urinalysis, bone marrow classification, organ weights, organ coefficient for Testing index, and be aided with the pathological examination that animal respectively organizes internal organs, the toxicity profile of overall merit medicine.The indices of result display rat is all normal.Histopathologic examination's result display, rat respectively organizes internal organs no abnormality seen.
In sum: the Chinese medicine composition toxicity of removal halitosis of the present invention is low, safety range is wide, and the Chinese medicine composition edible safety that the present invention removes halitosis is reliable.
Further illustrate the preparation method of the present composition by the following examples.
The preparation of embodiment 1 present composition oral liquid formulations
1) raw material (unit: × 10g) is taken according to following proportioning
Herba Eupatorii 4, Flos Caryophylli 4, Fructus Amomi 4, Herba Menthae 2
2) by after medical material Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 4 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 12:1;
3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 15 minutes, then filter, obtain extracting solution for subsequent use;
4) extracting solution is placed in vacuum high energy evaporation concentrator and carries out concentrating under reduced pressure, obtained Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution, wherein, the relative pressure of concentrating under reduced pressure be-0.07MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.07MPa relative to an atmospheric pressure), be heated to 80 DEG C, the weight of mixed concentrated liquid is 5:10 with the ratio of the gross weight of medicinal material mixture, namely carries out being evaporated to 50% of crude drug in whole weight;
5) Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution adds food preservative (potassium sorbate after being cooled to room temperature (15-30 DEG C), consumption is 0.05%, namely antiseptic 0.05g is added in every 100g concentrated solution), mix homogeneously, according to the consumption fill of every bottle of 10-20ml (being preferably 10ml), obtain the pure and fresh happy fragrant liquid of Chinese medicine composition book on Chinese herbal medicine of removal halitosis of the present invention.
The preparation of embodiment 2 present composition oral liquid formulations
1) raw material (unit: × 10g) is taken according to following proportioning
Herba Eupatorii 10, Flos Caryophylli 3, Fructus Amomi 6, Herba Menthae 1
2) by after medical material Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 3 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 8:1;
3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 15 minutes, then filter, obtain extracting solution for subsequent use;
4) extracting solution is placed in vacuum high energy evaporation concentrator and carries out concentrating under reduced pressure, obtained Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution, wherein, wherein, the relative pressure of concentrating under reduced pressure is-0.05MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.05MPa relative to an atmospheric pressure), is heated to 100 DEG C, the weight of mixed concentrated liquid is 9:10 with the ratio of the weight of medicinal material mixture, namely carries out being evaporated to 90% of crude drug in whole weight;
5) Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution adds food preservative (potassium sorbate after being cooled to room temperature (15-30 DEG C), consumption is 0.5%, namely antiseptic 0.5g is added in every 100g concentrated solution), mix homogeneously, according to the consumption fill of every bottle of 20ml, obtain the pure and fresh happy fragrant liquid of Chinese medicine composition book on Chinese herbal medicine of removal halitosis of the present invention.
The preparation of embodiment 3 present composition oral liquid formulations
1) raw material (unit: × 10g) is taken according to following proportioning
Herba Eupatorii 4, Flos Caryophylli 7, Fructus Amomi, Herba Menthae 2
2) by after medical material Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 2 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 15:1;
3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 10 minutes, then filter, obtain extracting solution for subsequent use;
4) extracting solution is placed in vacuum high energy evaporation concentrator and carries out concentrating under reduced pressure, obtained Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution, wherein, wherein, the relative pressure of concentrating under reduced pressure is-0.095MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.095MPa relative to an atmospheric pressure), is heated to 80 DEG C, the weight of mixed concentrated liquid is 7:10 with the ratio of the weight of medicinal material mixture, namely carries out being evaporated to 70% of crude drug in whole weight;
5) Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution adds food preservative (potassium sorbate after being cooled to room temperature (15-30 DEG C), consumption is 0.05%, namely antiseptic 0.05g is added in every 100g concentrated solution), mix homogeneously, according to the consumption fill of every bottle of 15ml, obtain the pure and fresh happy fragrant liquid of Chinese medicine composition book on Chinese herbal medicine of removal halitosis of the present invention.
The preparation of embodiment 4 present composition oral liquid formulations
1) raw material (unit: × 10g) is taken according to following proportioning
Herba Eupatorii 2, Flos Caryophylli 10, Fructus Amomi 1, Herba Menthae 5
2) by after medical material Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 5 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 6:1;
3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 20 minutes, then filter, obtain extracting solution for subsequent use;
4) extracting solution is placed in vacuum high energy evaporation concentrator and carries out concentrating under reduced pressure, obtained Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution, wherein, wherein, the relative pressure of concentrating under reduced pressure is-0.07MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.07MPa relative to an atmospheric pressure), is heated to 80 DEG C, the weight of mixed concentrated liquid is 8:10 with the ratio of the weight of medicinal material mixture, namely carries out being evaporated to 80% of crude drug in whole weight;
5) Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution adds food preservative (potassium sorbate after being cooled to room temperature (15-30 DEG C), consumption is 0.05%, namely antiseptic 0.05g is added in every 100g concentrated solution), mix homogeneously, according to the consumption fill of every bottle of 15ml, obtain the pure and fresh happy fragrant liquid of Chinese medicine composition book on Chinese herbal medicine of removal halitosis of the present invention.
The preparation of embodiment 5 present composition oral liquid formulations
1) raw material (unit: × 10g) is taken according to following proportioning
Herba Eupatorii 15, Flos Caryophylli 1, Fructus Amomi 12, Herba Menthae 1
2) by after medical material Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 4 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 12:1;
3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 15 minutes, then filter, obtain extracting solution for subsequent use;
4) extracting solution is placed in vacuum high energy evaporation concentrator and carries out concentrating under reduced pressure, obtained Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution, wherein, wherein, the relative pressure of concentrating under reduced pressure is-0.07MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.07MPa relative to an atmospheric pressure), is heated to 80 DEG C, the weight of mixed concentrated liquid is 6:10 with the ratio of the weight of medicinal material mixture, namely carries out being evaporated to 60% of crude drug in whole weight;
5) Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution adds food preservative (potassium sorbate after being cooled to room temperature (15-30 DEG C), consumption is 0.05%, namely antiseptic 0.05g is added in every 100g concentrated solution), mix homogeneously, according to the consumption fill of every bottle of 10ml, obtain the pure and fresh happy fragrant liquid of Chinese medicine composition book on Chinese herbal medicine of removal halitosis of the present invention.
The preparation of embodiment 6 present composition tablet
1) raw material (unit: × 10g) is taken according to following proportioning
Herba Eupatorii 4, Flos Caryophylli 4, Fructus Amomi 4, Herba Menthae 2
2) by after medical material Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 4 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 12:1;
3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 15 minutes, then filter, obtain extracting solution for subsequent use;
4) extracting solution is placed in vacuum high energy evaporation concentrator and carries out concentrating under reduced pressure, obtained Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution, wherein, the relative pressure of concentrating under reduced pressure be-0.07MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.07MPa relative to an atmospheric pressure), be heated to 80 DEG C, the weight of mixed concentrated liquid is 1:10 with the ratio of the gross weight of medicinal material mixture, namely carries out being evaporated to 10% of crude drug in whole weight;
5) Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution adds food preservative (potassium sorbate after being cooled to room temperature (15-30 DEG C), consumption is 0.05%, namely antiseptic 0.05g is added in every 100g concentrated solution) and adjuvant (starch, consumption is 50%, namely antiseptic 50g is added in every 100g concentrated solution), mix homogeneously, is placed in the Chinese medicine composition sheet that tablet machine is pressed into removal halitosis of the present invention, i.e. herbal pure and fresh happy scented tea.
The preparation of embodiment 7 present composition capsule
1) raw material (unit: × 10g) is taken according to following proportioning
Herba Eupatorii 10, Flos Caryophylli 3, Fructus Amomi 6, Herba Menthae 1
2) by after medical material Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 3 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 8:1;
3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 15 minutes, then filter, obtain extracting solution for subsequent use;
4) extracting solution is placed in vacuum high energy evaporation concentrator and carries out concentrating under reduced pressure, obtained Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution, wherein, wherein, the relative pressure of concentrating under reduced pressure is-0.05MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.05MPa relative to an atmospheric pressure), is heated to 100 DEG C, the weight of mixed concentrated liquid is 2:10 with the ratio of the weight of medicinal material mixture, namely carries out being evaporated to 20% of crude drug in whole weight;
5) Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution adds food preservative (potassium sorbate after being cooled to room temperature (15-30 DEG C), consumption is 0.5%, namely antiseptic 0.5g is added in every 100g concentrated solution) and adjuvant (microcrystalline Cellulose, consumption is 10%, namely antiseptic 10g is added in every 100g concentrated solution), dry after mix homogeneously, obtain the pure and fresh happy balosam capsule of Chinese medicine composition book on Chinese herbal medicine of removal halitosis of the present invention in incapsulating.
The preparation of embodiment 8 present composition granule
1) raw material (unit: × 10g) is taken according to following proportioning
Herba Eupatorii 4, Flos Caryophylli 7, Fructus Amomi, Herba Menthae 2
2) by after medical material Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 2 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 15:1;
3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 10 minutes, then filter, obtain extracting solution for subsequent use;
4) extracting solution is placed in vacuum high energy evaporation concentrator and carries out concentrating under reduced pressure, obtained Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution, wherein, wherein, the relative pressure of concentrating under reduced pressure is-0.095MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.095MPa relative to an atmospheric pressure), is heated to 80 DEG C, the weight of mixed concentrated liquid is 1:10 with the ratio of the weight of medicinal material mixture, namely carries out being evaporated to 10% of crude drug in whole weight;
5) Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution adds food preservative (potassium sorbate after being cooled to room temperature (15-30 DEG C), consumption is 0.05%, namely antiseptic 0.05g is added in every 100g concentrated solution) and adjuvant (microcrystalline Cellulose, consumption is 50%, namely antiseptic 50g is added in every 100g concentrated solution), make granule after mix homogeneously, obtain the pure and fresh happy fragrant granule of Chinese medicine composition book on Chinese herbal medicine of removal halitosis of the present invention.
The preparation of embodiment 9 present composition pill
1) raw material (unit: × 10g) is taken according to following proportioning
Herba Eupatorii 2, Flos Caryophylli 10, Fructus Amomi 1, Herba Menthae 5
2) by after medical material Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae rinsing, be placed in Multifunctional Chinese medicine and extract still and mix homogeneously, add tap water and soak 5 hours, wherein, the ratio of the weight of the tap water added and the weight (dry weight) of medicinal material mixture is 6:1;
3) open multi-functional extraction still power supply to heat, be heated to 100 DEG C, keep constant temperature at this temperature to extract 20 minutes, then filter, obtain extracting solution for subsequent use;
4) extracting solution is placed in vacuum high energy evaporation concentrator and carries out concentrating under reduced pressure, obtained Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution, wherein, wherein, the relative pressure of concentrating under reduced pressure is-0.07MPa (namely with an atmospheric pressure for 0, pressure when controlling concentrating under reduced pressure is-0.07MPa relative to an atmospheric pressure), is heated to 80 DEG C, the weight of mixed concentrated liquid is 3:10 with the ratio of the weight of medicinal material mixture, namely carries out being evaporated to 30% of crude drug in whole weight;
5) Herba Eupatorii-Flos Caryophylli-Fructus Amomi-Herba Menthae concentrated solution adds food preservative (potassium sorbate after being cooled to room temperature (15-30 DEG C), consumption is 0.05%, namely antiseptic 0.05g is added in every 100g concentrated solution) and adjuvant (dextrin, consumption is 50%, namely antiseptic 50g is added in every 100g concentrated solution), after mix homogeneously in pellet processing machine pill, obtain removal halitosis of the present invention Chinese medicine composition book on Chinese herbal medicine pure and fresh happy pomander.
Claims (10)
1. remove a Chinese medicine composition for halitosis, comprise following raw material: Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae.
2. compositions as claimed in claim 1, is characterized in that the weight of described crude drug is: Herba Eupatorii 2-15, Flos Caryophylli 1-10, Fructus Amomi 1-12, Herba Menthae 1-5.
3. compositions as claimed in claim 1 or 2, is characterized in that the weight of described crude drug is preferably: Herba Eupatorii 4-10, Flos Caryophylli 3-7, Fructus Amomi 2-6, Herba Menthae 1-2.
4. compositions as claimed in claim 3, is characterized in that the weight of described crude drug is: Herba Eupatorii 4, Flos Caryophylli 4, Fructus Amomi 4, Herba Menthae 2.
5. remove a preparation method for the Chinese medicine composition of halitosis, comprise the steps:
1) raw material is prepared according to following weight:
Herba Eupatorii 2-15, Flos Caryophylli 1-10, Fructus Amomi 1-12, Herba Menthae 1-5
2) by after Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae mix homogeneously, heating extraction is carried out to mixed material medicine, collect extracting solution;
3) concentration is carried out to the extracting solution collected, to obtain final product.
6. preparation method as claimed in claim 5, is characterized in that, step 2) described in heating extraction comprise the step that following order carries out:
A) mixture of Herba Eupatorii, Flos Caryophylli, Fructus Amomi, Herba Menthae is added water soaking, the weight of the water added is 6-15:1 with the ratio of the weight of mixture, soak 2-5 hour post-heating, be warming up to 100 DEG C, under maintenance temperature is the condition of 100 DEG C, extracts 10-20min;
B) mixture after heating is filtered, collect filtrate.
7. preparation method as claimed in claim 6, is characterized in that, steps A) described in heating extraction time 10-15min, the weight of the water added is preferably 8-12:1 with the ratio of the weight of mixture.
8. the preparation method as described in claim 5 or 6, is characterized in that, step 3) described in filtrate concentration process in control temperature be 80-100 DEG C, relative pressure is lower than-0.05MPa.
9. the preparation method as described in claim 5 or 6, is characterized in that, step 3) described in weight and the crude drug Herba Eupatorii of concentrated solution, Flos Caryophylli, Fructus Amomi and Herba Menthae the ratio of gross weight be 0.1-0.9:1.
10. the preparation method as described in claim 5 or 6, is characterized in that also comprising step 4) in the concentrated solution after concentration, add pharmaceutically acceptable adjuvant and antiseptic, mix homogeneously.
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| CN105639000A (en) * | 2015-12-30 | 2016-06-08 | 骆勇 | Herbal tea capable of freshening breath |
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Application publication date: 20150826 |