CN104825977A - Traditional Chinese medicine composition for treating spleen deficiency food damage type postpartum food damage and preparation method of traditional Chinese medicine composition - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating spleen deficiency food damage type postpartum food damage and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises polygonum paleaceum wall, malus yunnanensis, cynanchum auriculatum royle, mimosa pudica, ipomoea digitata sibirica, sapindus delavayi, phyllanthus urinaria, amomum tsaoko, hibiscus schizopetalus, root of common triplostegia, rhizoma sparganii, pyropolyporus fomentarius teng, radish's leaves, root of featherycleft horsegentian, herb of false indigo, immature bitter orange, arisaema franchetianum and herb of ghostplant wormwood. The traditional Chinese medicine composition has exact curative effect on treatment of the spleen deficiency food damage type postpartum food damage and has little toxic and side effects.

Description

A kind of Chinese medicine composition and preparation method for the treatment of insufficiency of the spleen type puerperal dyspepsia of getting ill from overeating

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine composition and preparation method for the treatment of insufficiency of the spleen type puerperal dyspepsia of getting ill from overeating.

Background technology

Puerperal dyspepsia refers to that puerperal, all functions were not answered, and taste are originally weak, if eating and drinking without temperance, and surfeit delicious food, impairing the spleen and stomach, then failing of the spleen to transport.Puerperal, spleen and stomach function did not recover, and as intemperance of taking food, depressed emotion, or have taste chronic disease, puerperal, temper was more empty, then food stagnation is in stomach, transporting mistake department and cause primary disease.

Tcm treatment according to syndrome differentiation, is generally divided into following three types:

Food stagnation hinders gastric pattern: puerperal, gastral cavilty distension, more so, eructating foul odor pantothenic acid, defecated dirty smelly in feed because of eating and drinking without temperance.Thick and greasy fur, stringy pulse or cunning.

Stagnation of liver-QI is got ill from overeating type: then flatulence of taking food puerperal, feeling of fullness and disecomfort in the chest and hypochondrium, belch acid regurgitation, depressed emotion, lochia is not smooth.Yellow and greasy fur, stringy pulse.

Insufficiency of the spleen type of getting ill from overeating: have taste chronic disease, gastral cavilty feeling of fullness, anorexia, spiritlessness and weakness, loose stool, shallow complexion.Thin fur, thready and weak pulse.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of Chinese medicine composition and preparation method for the treatment of insufficiency of the spleen type puerperal dyspepsia of getting ill from overeating, and Chinese medicine composition of the present invention has definite curative effect to the insufficiency of the spleen type puerperal dyspepsia of getting ill from overeating for the treatment of, and toxic and side effects is little.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of insufficiency of the spleen type puerperal dyspepsia of getting ill from overeating, its raw medicinal material comprises: Rhizoma Polygoni Paleachi, Fructus Malvae yunnanensis, Caulis et Folium Cynanchi Auriculati, Herba Mimosae Pudicae, Anisodus luridus Link. Et Otto, Semen Sapindi Delavayi, Cacumen Securinegae Suffruticosae, Fructus Tsaoko, Herba Ceropegiae Christensenianae, all draws, rhizoma scirpi, Pyropolyporus fomentarius (L.ex Fr.) Teng, Folium Raphani, Radix Triostei Pinnatifidi, Herba indigoferae Pseudotinctoriae, Fructus Aurantii Immaturus, resembles headdress flower and Herba artemisiae lactiflorae.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is as follows: Rhizoma Polygoni Paleachi 10 ~ 35 parts, Fructus Malvae yunnanensis 15 ~ 40 parts, Caulis et Folium Cynanchi Auriculati 10 ~ 20 parts, Herba Mimosae Pudicae 15 ~ 30 parts, Anisodus luridus Link. Et Otto 15 ~ 25 parts, Semen Sapindi Delavayi 10 ~ 30 parts, Cacumen Securinegae Suffruticosae 10 ~ 20 parts, Fructus Tsaoko 15 ~ 30 parts, Herba Ceropegiae Christensenianae 15 ~ 25 parts, all draws 10 ~ 20 parts, rhizoma scirpi 15 ~ 25 parts, Pyropolyporus fomentarius (L.ex Fr.) Teng 15 ~ 25 parts, Folium Raphani 15 ~ 30 parts, Radix Triostei Pinnatifidi 5 ~ 15 parts, Herba indigoferae Pseudotinctoriae 15 ~ 30 parts, Fructus Aurantii Immaturus 15 ~ 25 parts, resembles headdress flower 5 ~ 15 parts and Herba artemisiae lactiflorae 15 ~ 40 parts.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is as follows: Rhizoma Polygoni Paleachi 20 ~ 30 parts, Fructus Malvae yunnanensis 25 ~ 35 parts, Caulis et Folium Cynanchi Auriculati 15 ~ 20 parts, Herba Mimosae Pudicae 15 ~ 20 parts, Anisodus luridus Link. Et Otto 18 ~ 25 parts, Semen Sapindi Delavayi 20 ~ 30 parts, Cacumen Securinegae Suffruticosae 15 ~ 20 parts, Fructus Tsaoko 15 ~ 25 parts, Herba Ceropegiae Christensenianae 15 ~ 20 parts, all draws 15 ~ 20 parts, rhizoma scirpi 15 ~ 20 parts, Pyropolyporus fomentarius (L.ex Fr.) Teng 18 ~ 23 parts, Folium Raphani 15 ~ 20 parts, Radix Triostei Pinnatifidi 10 ~ 15 parts, Herba indigoferae Pseudotinctoriae 20 ~ 30 parts, Fructus Aurantii Immaturus 15 ~ 20 parts, resembles headdress flower 5 ~ 10 parts and Herba artemisiae lactiflorae 20 ~ 30 parts.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material also can be preferably: Rhizoma Polygoni Paleachi 27 parts, Fructus Malvae yunnanensis 33 parts, Caulis et Folium Cynanchi Auriculati 16 parts, Herba Mimosae Pudicae 20 parts, Anisodus luridus Link. Et Otto 23 parts, Semen Sapindi Delavayi 21 parts, Cacumen Securinegae Suffruticosae 16 parts, Fructus Tsaoko 18 parts, Herba Ceropegiae Christensenianae 15 parts, all draw 15 parts, rhizoma scirpi 19 parts, Pyropolyporus fomentarius (L.ex Fr.) Teng 19 parts, Folium Raphani 18 parts, Radix Triostei Pinnatifidi 10 parts, Herba indigoferae Pseudotinctoriae 27 parts, Fructus Aurantii Immaturus 18 parts, resembles headdress flower 6 parts and Herba artemisiae lactiflorae 20 parts.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material also can be preferably: Rhizoma Polygoni Paleachi 21 parts, Fructus Malvae yunnanensis 27 parts, Caulis et Folium Cynanchi Auriculati 18 parts, Herba Mimosae Pudicae 17 parts, Anisodus luridus Link. Et Otto 19 parts, Semen Sapindi Delavayi 27 parts, Cacumen Securinegae Suffruticosae 18 parts, Fructus Tsaoko 24 parts, Herba Ceropegiae Christensenianae 19 parts, all draw 17 parts, rhizoma scirpi 17 parts, Pyropolyporus fomentarius (L.ex Fr.) Teng 21 parts, Folium Raphani 15 parts, Radix Triostei Pinnatifidi 14 parts, Herba indigoferae Pseudotinctoriae 24 parts, Fructus Aurantii Immaturus 17 parts, resembles headdress flower 8 parts and Herba artemisiae lactiflorae 26 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 20 minutes ~ 40 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 2 ~ 4 times obtained relative to the first step is the ethanol of 70 ~ 80%, and reflux 1 ~ 3 hour, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 4 ~ 8 times again, each decoction 1 ~ 3 hour, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10 ~ 50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5 ~ 20%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 5%.

Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine is for during containing tablet, its preparation method comprises the following steps:

The first step, by Rhizoma Polygoni Paleachi, Fructus Malvae yunnanensis, Caulis et Folium Cynanchi Auriculati, Herba Mimosae Pudicae, Anisodus luridus Link. Et Otto and Semen Sapindi Delavayi mix in described ratio, and with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Cacumen Securinegae Suffruticosae, Fructus Tsaoko, Herba Ceropegiae Christensenianae, all draw, rhizoma scirpi, Pyropolyporus fomentarius (L.ex Fr.) Teng, Folium Raphani, Radix Triostei Pinnatifidi and Herba indigoferae Pseudotinctoriae mix in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

Beneficial effect of the present invention: Chinese medicine composition of the present invention has definite curative effect to the insufficiency of the spleen type puerperal dyspepsia of getting ill from overeating for the treatment of, and toxic and side effects is little.

Detailed description of the invention

The invention provides a kind of Chinese medicine composition for the treatment of insufficiency of the spleen type puerperal dyspepsia of getting ill from overeating, its raw medicinal material comprises: Rhizoma Polygoni Paleachi, Fructus Malvae yunnanensis, Caulis et Folium Cynanchi Auriculati, Herba Mimosae Pudicae, Anisodus luridus Link. Et Otto, Semen Sapindi Delavayi, Cacumen Securinegae Suffruticosae, Fructus Tsaoko, Herba Ceropegiae Christensenianae, all draws, rhizoma scirpi, Pyropolyporus fomentarius (L.ex Fr.) Teng, Folium Raphani, Radix Triostei Pinnatifidi, Herba indigoferae Pseudotinctoriae, Fructus Aurantii Immaturus, resembles headdress flower and Herba artemisiae lactiflorae.

In described Chinese medicine composition, the pharmacology of each raw medicinal material is as follows:

Rhizoma Polygoni Paleachi: [another name] the grass that has been eaten, careless blood agglomeration (" the southern regions of the Yunnan Province book on Chinese herbal medicine "), soil Sanguis Draxonis, haunch old (" Chinese medicine shape sex experience differential method "), golden yellow chicken (" the southern regions of the Yunnan Province book on Chinese herbal medicine " arranges this), circuitous head chicken, YIKOUXUE, Serpentis pimple (" Traditional Chinese Medicine in Sichuan will "), pale reddish brown, herb Potentillae cryptotaeniae, black honeybee, old arcus pelvicus (" choosing of Yunnan Chinese herbal medicine ").[source] is the rhizome of polygonaceae plant Rhizoma Polygoni Paleachi.Autumn excavates, and removes stem, leaf, silt particle, dries.[nature and flavor] are " the southern regions of the Yunnan Province book on Chinese herbal medicine " 1.: " tepor, toil is micro-puckery." [function cures mainly] loose blood hemostasis, therapeutic method to keep the adverse QI flowing downwards pain relieving.Control chronic gastritis, taste-blindness rate, food stagnation, lump in the abdomen, menoxenia, edema, traumatic injury, traumatic hemorrhage." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " the alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, disappear dyspepsia, and the mass in the abdomen that disappears year, hard long-pending plate was hard for a long time, stomach qi ache, the cold pain in face, gynecological mass in abdomen.Disappear edema, and removing blood stasis with potent drugs blood, cough-relieving is coughed." [extracts] " Chinese medicine voluminous dictionary "

Fructus Malvae yunnanensis: [another name] Yunnan Caulis et folium euphorbiae milii, Cratoaegus scabrifolia.[source] medical material Ji Yuan: be the fruit of rosaceous plant Fructus Malvae yunnanensis.[nature and flavor] are sour, sweet; Tepor.[return through] spleen; Stomach, liver three through [function cures mainly] stomach invigorating removing food stagnancy, clots absorbing analgesic therapy.Main retention of food and drink, abdominal distention, dysentery, has loose bowels, hernia, and puerpera's pillow is had a pain.[extracts] " China's book on Chinese herbal medicine "

Caulis et Folium Cynanchi Auriculati: [another name] Radix cynanchi wilfordii, Radix cynanchi wilfordii [Sichuan], white Radix Polygoni Multiflori [Jiangsu, Jiangxi], wild sweet potato, Radix Morindae Umbellatae, Radix Melothriae Heterophyllae, all ages bamboo, cut Serpentis pearl, mountain step tiger, wild Ipomoea batatas Lam. [source] be Luo Teng section Cynanchum plant Caulis et Folium Cynanchi Auriculati (cynanchum auriculatum Royle) Cynanchum auriculatumRoyle ex Wight, with root or all herbal medicine.Autumn adopts root; Summer, autumn gather herb, clean earth, dry for subsequent use.[nature and flavor] sweet, micro-hardship, flat.Slightly poisonous.[function cures mainly] stomach invigorating removing food stagnancy, removing toxic substances and promoting subsidence of swelling.For abdominal pain due to retention of food, stomachache, infantile malnutrition, dysentery; Venom is controlled in external, furuncle.[extracts] " national Chinese herbal medicine compilation "

Herba Mimosae Pudicae: [another name] knows shy grass (" South Uietnam notes "), coy grass (" the SHENGCAO property of medicine is standby to be wanted "), drink and exhale grass (" Guangxi leads to will "), be afraid of ugly grass (" Guangzhou flora "), Herba cassiae occidentalis (" Nanning City's medicine will ").[source] is the herb of leguminous plant Herba Mimosae Pudicae.Summer gathers, and dries.[nature and flavor] are sweet, cold, poisonous.[function cures mainly] heat clearing away, calms the nerves, removing food stagnancy, removing toxic substances.Control enteritis, gastritis, insomnia, infantile malnutrition, order heat swells and ache, deep abscess, herpes zoster." practical Chinese herbal medicine ": " clearing away heat-damp and promoting diuresis.Control deep abscess, enteritis, gastritis, hernia, infantile malnutrition." [extracts] " Chinese medicine voluminous dictionary "

Anisodus luridus Link. Et Otto: [another name] little morning glory.[source] Convolvulaceae Anisodus luridus Link. Et Otto Ipomoea sibiricaPers., is used as medicine with seed.[function cures mainly] to be relieved oedema or abdominal distension through diuresis or purgation detumescence, is rushed down down long-pending.[extracts] " national Chinese herbal medicine compilation "

Semen Sapindi Delavayi: [another name] bodhi pearl.[source] medical material Ji Yuan: be the fruits and seeds of Yunnan, sapindaceous plant river Fructus Sapindi Mukouossi.[nature and flavor] are bitter; Be slightly cold.[return through] kidney; Urinary bladder channel.[function cures mainly] circulation of qi promoting removing food stagnancy; Removing toxic substances parasite killing.Main hernia pain; Infantile malnutrition; Tonsillitis; Mumps; Mange; Impetigo; Ascariasis.[extracts] " China's book on Chinese herbal medicine "

Cacumen Securinegae Suffruticosae: Margarita, Ye Houzhu, cross Herba Phyllanthi Urinariae, silk tree grass, silk tree Margarita under [another name] Herba Phyllanthi Urinariae, leaf.[source] is Euphorbiaceae phyllanthus emblica platymiscium Cacumen Securinegae Suffruticosae Phyllanthus urinariaL., with all herbal medicine.Xia Qiu gathers herb, and decontamination, dries.[nature and flavor] micro-hardship, sweet, cool.[function cures mainly] clearing away heat and promoting diuresis, improving eyesight, removing food stagnancy.For oedema due to nephritis, urinary system infection, calculus, enteritis, dysentery, young waiter in a wineshop or an inn's infantile malnutrition, eye keratitis, icterohepatitis; External is controlled Trimeresurus stejnegeri and is bitten.[extracts] " national Chinese herbal medicine compilation "

Fructus Tsaoko: [another name] Fructus Tsaoko (" deliver a letter and be suitable for side "), SEMEN TSAOKO (" the total micro-opinion side of children's's health ").[source] is the fruit of zingiberaceous plant Fructus Tsaoko.10 ~ November, fruit started maturation, gathered when becoming bronzing and do not ftracture, and dried or low baking temperature oven dry.[nature and flavor] are pungent, temperature.[return through] " Thunder God concocts property of medicine solution ": " enter spleen, stomach two warp." except cold, eliminate the phlegm [function cures mainly] dampness preventing the attack (or recurrence) of malaria, the random treating malaria disease of digestion-promoting, phlegm retention feeling of fullness, coldness and pain in the epigastrium, regurgitation, vomiting, dysentery, food stagnation." herbal classic is met former ": " except cold, dampness, dissipating depression of QI, relieving dyspepsia, expectorant on sharp diaphragm, separates wheaten food, fish, all poison of meat." [extracts] " Chinese medicine voluminous dictionary "

Herba Ceropegiae Christensenianae: [another name] rip-panel Hibiscus rosasinensis, H schizopetalus, windbell Buddhist Flos Mori, five phoenixes flower, weave silk red, Flos Carthami, Nan Yang Flos Carthami.[source] medical material Ji Yuan: be the root of Malvaceae plant pendent lamp Hibiscus rosa-sinensis.[nature and flavor] are pungent; Cool.[return through] liver; Kidney channel.[function cures mainly] helps digestion capable stagnant.Staple food amasss [extracts] " China's book on Chinese herbal medicine "

All draw: [another name] all draws ginseng, Radix Triplostegiae Glanduliferae, native Herba Patriniae, Radix Satyrii nepalensis, Radix Raphani ginseng, Bai Doula, coelogyne flaccida cindl, Herba Achilleae, Radix Raphani Radix Triplostegiae Glanduliferae, Silene tatarinowii Regel-Melandrium tatarinwiii (Regel) Tsui., two perfume (or spice).[source] medical material Ji Yuan: be the root of Dipsacaceae plant southwest capsule bud flower.[nature and flavor] sweet in the mouth; Micro-hardship; Slightly warm in nature.[return through] lung; Spleen; Kidney channel.[function cures mainly] the kidney warming QI invigorating; Promoting blood circulation and hemostasis.Main body deadhead dusk; Asthenia chronic cough; Insufficiency of the spleen food stagnation; Lumbago due to renal deficiency; Leukorrhagia; Sexual impotence; Infertile; Rheumatic heart disease; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Rhizoma scirpi: [another name] Rhizoma Sparganii, bubble Rhizoma Sparganii.[source] medical material Ji Yuan: be the tuber of sedge cyperus iria L. rhizoma scirpi.[nature and flavor] acrid in the mouth; Bitter; Property is put down.[return through] liver; Spleen channel [function cures mainly] blood stasis dispelling stimulates the menstrual flow; Removing blood stasis eliminating mass; Circulation of qi promoting removing food stagnancy.Main amenorrhea due to stagnation of blood; Dysmenorrhea; Postpartum stagnation is suffered from abdominal pain; Traumatic injury congestive edema; Enclosed mass in abdomen; Abdominal pain due to retention of food.[extracts] " China's book on Chinese herbal medicine "

Pyropolyporus fomentarius (L.ex Fr.) Teng: [another name] Fomes Fomentarius.The brown layer hole of [source] Polyporaceae belongs to fungi plant Pyropolyporus fomentarius (L.ex Fr.) Teng Pyropolyporus fomentarius (L.ex Fr.) Teng. and is used as medicine with thalline.6 ~ July gathers, and dries.[nature and flavor] are bitter, light, flat.[function cures mainly] removing food stagnancy, anticancer.For food stagnation of child, esophageal carcinoma, gastric cancer, uterus carcinoma.[extracts] " national Chinese herbal medicine compilation "

Folium Raphani: [another name] Radix Raphani bar (" the southern regions of the Yunnan Province book on Chinese herbal medicine "), Radix Raphani dish (" Bencao Congxin) ", radish (" book on Chinese herbal medicine is new again "), Radix Raphani first (" modern Practical Chinese medicinal "), Radix Raphani first (" medicine will is planted in Jiangsu ").[source] is the root leaf of crucifer Radix Raphani.Winter or early spring gather.Air-dry or dry.[nature and flavor] work hard, flat.[return through] be " the southern regions of the Yunnan Province book on Chinese herbal medicine " 1.: " enter spleen, stomach two warp." [function cures mainly] helps digestion, and regulates the flow of vital energy.Control chest and diaphragm feeling of fullness to do oh, dyspepsia does not disappear, dysentery, laryngalgia, women's swelling of the breast, galactostasis." book on Chinese herbal medicine is new again ": " preventing phlegm from forming and stopping coughing helps digestion and regulates the flow of vital energy." [extracts] " Chinese medicine voluminous dictionary "

Radix Triostei Pinnatifidi: [another name] Herba Triostei himalayani, in vain sudden and violent seven, chicken feet seven.[source] splits the root of the stem of a herb Fischer for caprifoliaceae plant plumage.Autumn end excavates.Clean, dry.[nature and flavor] are pained, flat.[function cures mainly] wind-damp dispelling, vital energy regualting and blood circulation-promoting, strengthening the spleen and stomach, anti-inflammatory analgesic, granulation promoting.Control impairment caused by overstrain, lumbago, skelalgia of rheumatism, traumatic injury, dyspepsia, menoxenia, leucorrhea.[extracts] " Chinese medicine voluminous dictionary "

Herba indigoferae Pseudotinctoriae: [another name] wild Sophora japonica L. mountain Fructus Gleditsia, iron soap angle, mountain Semen phaseoli radiati, Herba indigoferae Pseudotinctoriae, the pale reddish brown material tip, wild Semen phaseoli radiati, the horse material tip, night close grass, Semen phaseoli radiati bavin, suffering happiness, Semen Sojae Preparatum wood.[source] medical material Ji Yuan: be root or the aerial parts of leguminous plant horse sour jujube.[nature and flavor] bitter in the mouth; Puckery; Property is put down.[return through] spleen, stomach warp.[function cures mainly] clearing away heat and expelling pathogen in the exterior; Dissipating blood stasis removing food stagnancy.Main anemopyretic cold; Cough due to lung-heat; Burn and scald; Furuncle; Venom; Scrofula; Traumatic injury; Dyspeptic abdominal distention.[extracts] " China's book on Chinese herbal medicine "

Fructus Aurantii Immaturus: [source] this product is the dry young fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety or Fructus Citri sinensis Citrus sinensis Osbeck.5 ~ June collects the fruit from falling, and removing impurity, be two halves from middle part crosscut, dry or cold drying, smaller directly dries or cold drying.[nature and flavor] are bitter, pungent, sour, temperature.[return through] returns spleen, stomach warp.[function cures mainly] dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest; Gastroptosis, proctoptosis, uterine prolapse.[extracts] " Chinese Pharmacopoeia "

Resemble headdress flower: [another name] red Rhizoma Arisaematis, Rhizoma Arisaematis, the large Rhizoma Pinelliae, solely the leaf Rhizoma Pinelliae, little Typhonium divaricatum (L.) Decne.[source] Araeceae Arisaema plant franchet jackinthepulpit rhizome Arisaema francketianum Engl., is used as medicine with tuber.Summer excavates, and dries.[nature and flavor] are pungent, temperature.Very toxic.[function cures mainly] dissipating blood stasis detoxifies, reducing swelling and alleviating pain.For stomachache, mastitis, furuncle toxic swelling, lymphoid tuberculosis, venom.[extracts] " national Chinese herbal medicine compilation "

Herba artemisiae lactiflorae: [another name] Qin Zhouan (the Lv gate of a village), chicken Herba artemisiae lactiflorae, Radix Betae, open country are strangled dish, four seasons dish, chicken Radix Betae, duck foot dish, sweet Chinese mugwort, Cornmarigold, native loach dish, Herba Artemisiae Anomalae, Radix seu Caulis Embeliae Parviflorae, spend Artemisia, smallage in vain, spent Chinese mugwort in vain, rice Artemisia, Herba Senecionis Chrysanthemoidis, pulmonary tuberculosis are careless, red aunt's dish.[source] medical material Ji Yuan: be herb or the root of feverfew Artemisia lactiflora Wall..[nature and flavor] acrid in the mouth; Micro-hardship; Slightly warm in nature.[function cures mainly] promoting blood circulation to remove blood stasis; Regulating QI to expel dampness.Main dysmenorrhea due to blood stasis; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Chronic hepatitis; Hepatosplenomegaly; Dyspeptic abdominal distention; Cold-damp is had loose bowels; Hernia; Carbuncle of yin nature swells and ache; Traumatic injury; Burn due to hot liquid or fire.[extracts] " China's book on Chinese herbal medicine "

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is as follows: Rhizoma Polygoni Paleachi 10 ~ 35 parts, Fructus Malvae yunnanensis 15 ~ 40 parts, Caulis et Folium Cynanchi Auriculati 10 ~ 20 parts, Herba Mimosae Pudicae 15 ~ 30 parts, Anisodus luridus Link. Et Otto 15 ~ 25 parts, Semen Sapindi Delavayi 10 ~ 30 parts, Cacumen Securinegae Suffruticosae 10 ~ 20 parts, Fructus Tsaoko 15 ~ 30 parts, Herba Ceropegiae Christensenianae 15 ~ 25 parts, all draws 10 ~ 20 parts, rhizoma scirpi 15 ~ 25 parts, Pyropolyporus fomentarius (L.ex Fr.) Teng 15 ~ 25 parts, Folium Raphani 15 ~ 30 parts, Radix Triostei Pinnatifidi 5 ~ 15 parts, Herba indigoferae Pseudotinctoriae 15 ~ 30 parts, Fructus Aurantii Immaturus 15 ~ 25 parts, resembles headdress flower 5 ~ 15 parts and Herba artemisiae lactiflorae 15 ~ 40 parts.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably: Rhizoma Polygoni Paleachi 20 ~ 30 parts, Fructus Malvae yunnanensis 25 ~ 35 parts, Caulis et Folium Cynanchi Auriculati 15 ~ 20 parts, Herba Mimosae Pudicae 15 ~ 20 parts, Anisodus luridus Link. Et Otto 18 ~ 25 parts, Semen Sapindi Delavayi 20 ~ 30 parts, Cacumen Securinegae Suffruticosae 15 ~ 20 parts, Fructus Tsaoko 15 ~ 25 parts, Herba Ceropegiae Christensenianae 15 ~ 20 parts, all draws 15 ~ 20 parts, rhizoma scirpi 15 ~ 20 parts, Pyropolyporus fomentarius (L.ex Fr.) Teng 18 ~ 23 parts, Folium Raphani 15 ~ 20 parts, Radix Triostei Pinnatifidi 10 ~ 15 parts, Herba indigoferae Pseudotinctoriae 20 ~ 30 parts, Fructus Aurantii Immaturus 15 ~ 20 parts, resembles headdress flower 5 ~ 10 parts and Herba artemisiae lactiflorae 20 ~ 30 parts.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material also can be preferably: Rhizoma Polygoni Paleachi 27 parts, Fructus Malvae yunnanensis 33 parts, Caulis et Folium Cynanchi Auriculati 16 parts, Herba Mimosae Pudicae 20 parts, Anisodus luridus Link. Et Otto 23 parts, Semen Sapindi Delavayi 21 parts, Cacumen Securinegae Suffruticosae 16 parts, Fructus Tsaoko 18 parts, Herba Ceropegiae Christensenianae 15 parts, all draw 15 parts, rhizoma scirpi 19 parts, Pyropolyporus fomentarius (L.ex Fr.) Teng 19 parts, Folium Raphani 18 parts, Radix Triostei Pinnatifidi 10 parts, Herba indigoferae Pseudotinctoriae 27 parts, Fructus Aurantii Immaturus 18 parts, resembles headdress flower 6 parts and Herba artemisiae lactiflorae 20 parts.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material also can be preferably: Rhizoma Polygoni Paleachi 21 parts, Fructus Malvae yunnanensis 27 parts, Caulis et Folium Cynanchi Auriculati 18 parts, Herba Mimosae Pudicae 17 parts, Anisodus luridus Link. Et Otto 19 parts, Semen Sapindi Delavayi 27 parts, Cacumen Securinegae Suffruticosae 18 parts, Fructus Tsaoko 24 parts, Herba Ceropegiae Christensenianae 19 parts, all draw 17 parts, rhizoma scirpi 17 parts, Pyropolyporus fomentarius (L.ex Fr.) Teng 21 parts, Folium Raphani 15 parts, Radix Triostei Pinnatifidi 14 parts, Herba indigoferae Pseudotinctoriae 24 parts, Fructus Aurantii Immaturus 17 parts, resembles headdress flower 8 parts and Herba artemisiae lactiflorae 26 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 20 minutes ~ 40 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 2 ~ 4 times obtained relative to the first step is the ethanol of 70 ~ 80%, and reflux 1 ~ 3 hour, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 4 ~ 8 times again, each decoction 1 ~ 3 hour, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10 ~ 50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5 ~ 20%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 5%.

Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine is for during containing tablet, its preparation method comprises the following steps:

The first step, by Rhizoma Polygoni Paleachi, Fructus Malvae yunnanensis, Caulis et Folium Cynanchi Auriculati, Herba Mimosae Pudicae, Anisodus luridus Link. Et Otto and Semen Sapindi Delavayi mix in described ratio, and with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Cacumen Securinegae Suffruticosae, Fructus Tsaoko, Herba Ceropegiae Christensenianae, all draw, rhizoma scirpi, Pyropolyporus fomentarius (L.ex Fr.) Teng, Folium Raphani, Radix Triostei Pinnatifidi and Herba indigoferae Pseudotinctoriae mix in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

Embodiment 1: capsule

Get Rhizoma Polygoni Paleachi 270g, Fructus Malvae yunnanensis 330g, Caulis et Folium Cynanchi Auriculati 160g, Herba Mimosae Pudicae 200g, Anisodus luridus Link. Et Otto 230g, Semen Sapindi Delavayi 210g, Cacumen Securinegae Suffruticosae 160g, Fructus Tsaoko 180g, Herba Ceropegiae Christensenianae 150g, all draw 150g, rhizoma scirpi 190g, Pyropolyporus fomentarius (L.ex Fr.) Teng 190g, Folium Raphani 180g, Radix Triostei Pinnatifidi 100g, Herba indigoferae Pseudotinctoriae 270g, Fructus Aurantii Immaturus 180g, resembles headdress flower 60g and Herba artemisiae lactiflorae 200g.

Prepare according to the following steps:

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 30 minutes, be ground into smalls, be screened into 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 3 times obtained relative to the first step is the ethanol of 80%, and reflux 3 hours, extracts 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 8 times again, and each decoction 3 hours, decocts 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mixes with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract;

3rd step, is broken into 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Excipient is calcium hydrogen phosphate, and its weight content in capsule is 25%;

Disintegrating agent is sodium carboxymethyl cellulose, and its weight content in capsule is 15%;

Fluidizer is differential silica gel, and its weight content in capsule is 2%.

Embodiment 2: containing tablet

Get Rhizoma Polygoni Paleachi 210g, Fructus Malvae yunnanensis 270g, Caulis et Folium Cynanchi Auriculati 180g, Herba Mimosae Pudicae 170g, Anisodus luridus Link. Et Otto 190g, Semen Sapindi Delavayi 270g, Cacumen Securinegae Suffruticosae 180g, Fructus Tsaoko 240g, Herba Ceropegiae Christensenianae 190g, all draw 170g, rhizoma scirpi 170g, Pyropolyporus fomentarius (L.ex Fr.) Teng 210g, Folium Raphani 150g, Radix Triostei Pinnatifidi 140g, Herba indigoferae Pseudotinctoriae 240g, Fructus Aurantii Immaturus 170g, resembles headdress flower 80g and Herba artemisiae lactiflorae 260g.

Prepare according to the following steps:

The first step, by Rhizoma Polygoni Paleachi, Fructus Malvae yunnanensis, Caulis et Folium Cynanchi Auriculati, Herba Mimosae Pudicae, Anisodus luridus Link. Et Otto and Semen Sapindi Delavayi mix in described ratio, and with the dissolve with ethanol of the determining alcohol 95% of 6 times relative to the mixture quality obtained, reflux was extracted after 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 95% of 4 times relative to the mixture quality obtained, reflux was extracted after 1 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90%% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Cacumen Securinegae Suffruticosae, Fructus Tsaoko, Herba Ceropegiae Christensenianae, all draws, rhizoma scirpi, Pyropolyporus fomentarius (L.ex Fr.) Teng, Folium Raphani, Radix Triostei Pinnatifidi and Herba indigoferae Pseudotinctoriae mix in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 90% of 4 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the mastic of 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 3 times relative to the mixture quality obtained, and heating decoction 3 hours, filters; By filtering residue again with the water dissolution of 2 times relative to the mixture quality obtained, heating decoction 2 hours, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 times, the microcrystalline Cellulose of 0.05 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 23 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 7.28g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.4 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>36.4 crude drug/kg of the present invention, every day, maximum dosage-feeding was 72.8 crude drugs/kg/ day.Chinese medicine composition clinical application amount of the present invention be 6.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.107g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 26g) oral administration gavage Chinese medicine composition of the present invention is 680 times of quantity.Therefore Chinese medicine composition acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine composition embodiment 1 capsule of the present invention presses 13.35,19.26 and 38.33g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine composition of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine composition of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: this group 200 example, to give a birth for my institute in April, 2012 ~ 2,014 200 examples of puerperal dyspepsia occur in puerpera 7960 people year March.At 25 ~ 45 years old age, be divided into treatment group and matched group at random.Two groups of ages, the course of disease, clinical manifestation and equal not statistically significants of coincident with severity degree of condition comparing difference (p>0.05).

Diagnostic criteria:

, there is flatulence, abdominal distention or dyspepsia in Western medicine diagnose standard: inappetence appears in puerperal, can with rotten odor belch after feed, pantothenic acid, feels sick, the diseases such as vomiting, and patient does not suffer from intestinal obstruction that digestive tract ulcer and cesarean postoperate cause or intestinal adhesion etc.

Syndrome Types of TCM diagnostic criteria: insufficiency of the spleen type of getting ill from overeating: have taste chronic disease, gastral cavilty feeling of fullness, anorexia, spiritlessness and weakness, loose stool, shallow complexion.Thin fur, thready and weak pulse.

Treatment group: take the embodiment of the present invention 1 capsule every day 3 times, each 4,1 week 1 course for the treatment of; Be used in conjunction two courses for the treatment of.

Matched group: take Chinese patent medicine JIANWEI XIAOSHI PIAN every day 3 times, each 3,1 week 1 course for the treatment of; Be used in conjunction two courses for the treatment of.

Curative effect judging standard: cure: the symptoms such as anorexia flatulence all disappear, and the mental status is good; Take a turn for the better: the symptoms such as anorexia flatulence are clearly better, and the mental status is obviously improved; Do not heal: still anorexia, the mental status is poor.

Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result is see table 1 and table 2.As can be seen from Table 1, adopt the insufficiency of the spleen type puerperal dyspepsia of getting ill from overeating for the treatment of by Chinese herbs of the present invention, relative to matched group on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt the insufficiency of the spleen type puerperal dyspepsia of getting ill from overeating for the treatment of by Chinese herbs of the present invention, relative to Chinese patent medicine, treatment the course for the treatment of on significantly shorten.

After table 1 liang group treats 2 courses for the treatment of respectively, Clinical efficacy comparison is routine

Group	n	Cure	Take a turn for the better	Do not heal	Effectively total
						Treatment group	100	83	17	0	100(100％)
Matched group	100	48	35	17	83(83％)

Number and time comparative example (%) is cured after a table 2 liang group treats 2 courses for the treatment of respectively

Group	Number of cases	Medication 5 days	Medication 10 days	Medication 14 days
					Treatment group	83	27(27％)	73(73％)	83(83％)
Matched group	48	9(9％)	26(26％)	48(48％)

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Follow up a case by regular visits to 3 months respectively to the 48 routine patients that 83 routine patients and the matched group for the treatment of group healing are cured, result is added up, and the routine patient for the treatment of group 85 is without recurrence, and relapse rate is 0% simultaneously; The routine patient of matched group 48, recurs 6 people, relapse rate 12.5%.

Concrete case: Zhao, women, 31 years old, there is inappetence in puerperal, occurs flatulence after feed, the diseases such as dyspepsia, have taste chronic disease, gastral cavilty feeling of fullness, anorexia, spiritlessness and weakness, loose stool, shallow complexion, thin fur, thready and weak pulse, is diagnosed as insufficiency of the spleen type puerperal dyspepsia of getting ill from overeating.Take Chinese medicine composition embodiment 1 capsule of the present invention every day 3 times, each 4, treat after 9 days, recovery from illness, follows up a case by regular visits to and does not recur for 3 months.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat a Chinese medicine composition for insufficiency of the spleen type puerperal dyspepsia of getting ill from overeating, it is characterized in that, comprise following raw medicinal material: Rhizoma Polygoni Paleachi, Fructus Malvae yunnanensis, Caulis et Folium Cynanchi Auriculati, Herba Mimosae Pudicae, Anisodus luridus Link. Et Otto, Semen Sapindi Delavayi, Cacumen Securinegae Suffruticosae, Fructus Tsaoko, Herba Ceropegiae Christensenianae, all draws, rhizoma scirpi, Pyropolyporus fomentarius (L.ex Fr.) Teng, Folium Raphani, Radix Triostei Pinnatifidi, Herba indigoferae Pseudotinctoriae, Fructus Aurantii Immaturus, resembles headdress flower and Herba artemisiae lactiflorae.

2. Chinese medicine composition as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine composition is as follows: Rhizoma Polygoni Paleachi 10 ~ 35 parts, Fructus Malvae yunnanensis 15 ~ 40 parts, Caulis et Folium Cynanchi Auriculati 10 ~ 20 parts, Herba Mimosae Pudicae 15 ~ 30 parts, Anisodus luridus Link. Et Otto 15 ~ 25 parts, Semen Sapindi Delavayi 10 ~ 30 parts, Cacumen Securinegae Suffruticosae 10 ~ 20 parts, Fructus Tsaoko 15 ~ 30 parts, Herba Ceropegiae Christensenianae 15 ~ 25 parts, all draw 10 ~ 20 parts, rhizoma scirpi 15 ~ 25 parts, Pyropolyporus fomentarius (L.ex Fr.) Teng 15 ~ 25 parts, Folium Raphani 15 ~ 30 parts, Radix Triostei Pinnatifidi 5 ~ 15 parts, Herba indigoferae Pseudotinctoriae 15 ~ 30 parts, Fructus Aurantii Immaturus 15 ~ 25 parts, resemble headdress flower 5 ~ 15 parts and Herba artemisiae lactiflorae 15 ~ 40 parts.

3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine composition is as follows: Rhizoma Polygoni Paleachi 20 ~ 30 parts, Fructus Malvae yunnanensis 25 ~ 35 parts, Caulis et Folium Cynanchi Auriculati 15 ~ 20 parts, Herba Mimosae Pudicae 15 ~ 20 parts, Anisodus luridus Link. Et Otto 18 ~ 25 parts, Semen Sapindi Delavayi 20 ~ 30 parts, Cacumen Securinegae Suffruticosae 15 ~ 20 parts, Fructus Tsaoko 15 ~ 25 parts, Herba Ceropegiae Christensenianae 15 ~ 20 parts, all draw 15 ~ 20 parts, rhizoma scirpi 15 ~ 20 parts, Pyropolyporus fomentarius (L.ex Fr.) Teng 18 ~ 23 parts, Folium Raphani 15 ~ 20 parts, Radix Triostei Pinnatifidi 10 ~ 15 parts, Herba indigoferae Pseudotinctoriae 20 ~ 30 parts, Fructus Aurantii Immaturus 15 ~ 20 parts, resemble headdress flower 5 ~ 10 parts and Herba artemisiae lactiflorae 20 ~ 30 parts.

4. the Chinese medicine composition as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine composition is as follows: Rhizoma Polygoni Paleachi 27 parts, Fructus Malvae yunnanensis 33 parts, Caulis et Folium Cynanchi Auriculati 16 parts, Herba Mimosae Pudicae 20 parts, Anisodus luridus Link. Et Otto 23 parts, Semen Sapindi Delavayi 21 parts, Cacumen Securinegae Suffruticosae 16 parts, Fructus Tsaoko 18 parts, Herba Ceropegiae Christensenianae 15 parts, all draws 15 parts, rhizoma scirpi 19 parts, Pyropolyporus fomentarius (L.ex Fr.) Teng 19 parts, Folium Raphani 18 parts, Radix Triostei Pinnatifidi 10 parts, Herba indigoferae Pseudotinctoriae 27 parts, Fructus Aurantii Immaturus 18 parts, resembles headdress flower 6 parts and Herba artemisiae lactiflorae 20 parts.

5. the Chinese medicine composition as described in Claims 1-4, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine composition is as follows: Rhizoma Polygoni Paleachi 21 parts, Fructus Malvae yunnanensis 27 parts, Caulis et Folium Cynanchi Auriculati 18 parts, Herba Mimosae Pudicae 17 parts, Anisodus luridus Link. Et Otto 19 parts, Semen Sapindi Delavayi 27 parts, Cacumen Securinegae Suffruticosae 18 parts, Fructus Tsaoko 24 parts, Herba Ceropegiae Christensenianae 19 parts, all draws 17 parts, rhizoma scirpi 17 parts, Pyropolyporus fomentarius (L.ex Fr.) Teng 21 parts, Folium Raphani 15 parts, Radix Triostei Pinnatifidi 14 parts, Herba indigoferae Pseudotinctoriae 24 parts, Fructus Aurantii Immaturus 17 parts, resembles headdress flower 8 parts and Herba artemisiae lactiflorae 26 parts.

6. the Chinese medicine composition as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine composition is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 20 minutes ~ 40 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 2 ~ 4 times obtained relative to the first step is the ethanol of 70 ~ 80%, and reflux 1 ~ 3 hour, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 4 ~ 8 times again, each decoction 1 ~ 3 hour, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10 ~ 50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5 ~ 20%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 5%.

7. Chinese medicine composition as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is for containing tablet, and its preparation method comprises the following steps:

The first step, by Rhizoma Polygoni Paleachi, Fructus Malvae yunnanensis, Caulis et Folium Cynanchi Auriculati, Herba Mimosae Pudicae, Anisodus luridus Link. Et Otto and Semen Sapindi Delavayi mix in described ratio, and with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Cacumen Securinegae Suffruticosae, Fructus Tsaoko, Herba Ceropegiae Christensenianae, all draw, rhizoma scirpi, Pyropolyporus fomentarius (L.ex Fr.) Teng, Folium Raphani, Radix Triostei Pinnatifidi and Herba indigoferae Pseudotinctoriae mix in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

8. a preparation method for the Chinese medicine composition described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine composition is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 20 minutes ~ 40 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 2 ~ 4 times obtained relative to the first step is the ethanol of 70 ~ 80%, and reflux 1 ~ 3 hour, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 4 ~ 8 times again, each decoction 1 ~ 3 hour, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10 ~ 50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5 ~ 20%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 5%.

9. a preparation method for Chinese medicine composition described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is for containing tablet, and its preparation method comprises the following steps:

The first step, by Rhizoma Polygoni Paleachi, Fructus Malvae yunnanensis, Caulis et Folium Cynanchi Auriculati, Herba Mimosae Pudicae, Anisodus luridus Link. Et Otto and Semen Sapindi Delavayi mix in described ratio, and with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Cacumen Securinegae Suffruticosae, Fructus Tsaoko, Herba Ceropegiae Christensenianae, all draw, rhizoma scirpi, Pyropolyporus fomentarius (L.ex Fr.) Teng, Folium Raphani, Radix Triostei Pinnatifidi and Herba indigoferae Pseudotinctoriae mix in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.