CN104792902B - 一种氯化钠注射液中氯化钠含量的测定方法 - Google Patents
一种氯化钠注射液中氯化钠含量的测定方法 Download PDFInfo
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- CN104792902B CN104792902B CN201510238978.6A CN201510238978A CN104792902B CN 104792902 B CN104792902 B CN 104792902B CN 201510238978 A CN201510238978 A CN 201510238978A CN 104792902 B CN104792902 B CN 104792902B
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- Prior art keywords
- sodium chloride
- high performance
- performance liquid
- water
- alcohol
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 title claims abstract description 32
- 239000011780 sodium chloride Substances 0.000 title claims abstract description 16
- 239000008354 sodium chloride injection Substances 0.000 title claims abstract description 13
- 238000003556 assay Methods 0.000 title claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000004128 high performance liquid chromatography Methods 0.000 claims abstract description 8
- 238000004090 dissolution Methods 0.000 claims abstract description 4
- 239000007921 spray Substances 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 11
- 239000011159 matrix material Substances 0.000 claims description 8
- 239000002245 particle Substances 0.000 description 6
- 239000012491 analyte Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000008187 granular material Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
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- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
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CN201510238978.6A CN104792902B (zh) | 2015-05-12 | 2015-05-12 | 一种氯化钠注射液中氯化钠含量的测定方法 |
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CN201510238978.6A CN104792902B (zh) | 2015-05-12 | 2015-05-12 | 一种氯化钠注射液中氯化钠含量的测定方法 |
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CN104792902A CN104792902A (zh) | 2015-07-22 |
CN104792902B true CN104792902B (zh) | 2016-06-29 |
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CN201510238978.6A Active CN104792902B (zh) | 2015-05-12 | 2015-05-12 | 一种氯化钠注射液中氯化钠含量的测定方法 |
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CN (1) | CN104792902B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009124294A2 (en) * | 2008-04-05 | 2009-10-08 | Lpath, Inc. | Pharmaceutical compositions for binding sphingosine-1-phosphate |
CN102445500A (zh) * | 2010-10-14 | 2012-05-09 | 天津天士力之骄药业有限公司 | 一种检测注射用益气复脉中的大分子物质的方法 |
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2015
- 2015-05-12 CN CN201510238978.6A patent/CN104792902B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009124294A2 (en) * | 2008-04-05 | 2009-10-08 | Lpath, Inc. | Pharmaceutical compositions for binding sphingosine-1-phosphate |
CN102445500A (zh) * | 2010-10-14 | 2012-05-09 | 天津天士力之骄药业有限公司 | 一种检测注射用益气复脉中的大分子物质的方法 |
Non-Patent Citations (4)
Title |
---|
Determination of inorganic pharmaceutical counterions using hydrophilic interaction chromatography coupled with a Corona CAD detector;Z.Huang等;《Journal of Pharmaceutical and Biomedical Analysis》;20091231;第50卷;第809-814页 * |
Evaluation of Methods for the Simultaneous Analysis of Cations and Anions Using HPLC with Charged Aerosol Detection and a Zwitterionic Stationary Phase;Christopher Crafts等;《Journal of Chromatographic Science》;20090831;第47卷;第534-539页 * |
Simultaneous determination of positive and negative pharmaceutical counterions using mixed-mode chromatography coupled with charged aerosol detector;Ke Zhang等;《Journal of Chromatography A》;20101231;第1217卷;第5776-5784页 * |
一种新型的通用型检测器——电喷雾检测器;刘立洋等;《现代科学仪器》;20111031(第5期);第141-145页 * |
Also Published As
Publication number | Publication date |
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CN104792902A (zh) | 2015-07-22 |
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Effective date of registration: 20180105 Address after: 543000 the Guangxi Zhuang Autonomous Region Cenxi North Road No. 5 Patentee after: Cenxi Productivity Promotion Center Address before: 543000 the Guangxi Zhuang Autonomous Region, Wuzhou West Ring Road, No. 198 Patentee before: WUZHOU INSTITUTE FOR FOOD AND DRUG CONTROL, GUANGXI ZHUANG AUTONOMOUS REGION |
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Inventor after: Sun Liangguang Inventor after: Guo Zhenwang Inventor after: Chen Xuesong Inventor after: Lai Xiumei Inventor after: Huang Heng Inventor after: Li Zhirui Inventor after: Zhang Yunping Inventor before: Chen Xuesong Inventor before: Lai Xiumei Inventor before: Huang Heng Inventor before: Li Zhirui Inventor before: Zhang Yunping |
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Application publication date: 20150722 Assignee: GUANGXI GUILIN RUIDE DETECTION AUTHENTICATION TECHNOLOGY Co.,Ltd. Assignor: WUZHOU FOOD AND DRUG INSPECTION INSTITUTE Contract record no.: X2022450000291 Denomination of invention: A method for determination of sodium chloride content in sodium chloride injection Granted publication date: 20160629 License type: Common License Record date: 20221214 |
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