CN104783829B - The processing method and system of single photon emission tomographic imaging - Google Patents
The processing method and system of single photon emission tomographic imaging Download PDFInfo
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Abstract
The present invention proposes a kind of processing method and system of single photon emission tomographic imaging, and this method includes:Digitized sampling waveform signal;Input is default can the window upper limit, energy window lower limit and baseline offset;Digital baseline is rejected to digitlization waveform signal according to the baseline offset;Threshold signal was extracted from digitized wave forms signal;Summed up to crossing threshold signal, realize the digital integration of energy;The mistake threshold signal after Integral Processing is integrated according to the energy window upper limit, energy window lower limit, complete threshold event excessively is obtained.The method of the present invention has speed fast, and parallel processing capability is strong, it is easy to the features such as upgrading, it is adaptable to the electronics equipment in Digitized ergonomic single photon emission tomographic imaging equipment.
Description
Technical field
The present invention relates to single photon emission tomographic imaging technical field, more particularly to a kind of single photon emission tomographic imaging
Processing method and system.
Background technology
The purpose of single photon emission tomographic imaging equipment is to detect the distribution map with rebuilding the tracer in human organ.
This distribution map can reflect human tissue structure and corresponding physiological activity.The change of this distribution map over time, can be with
Reflect the metabolic condition of tissue and organ.Single photon emission computed tomography (SPECT) system is used for diagnosing tumor in clinic
With discriminating, also it is widely used in thyroid gland is diagnosed with cardiovascular activity.
Single photon emission computed tomography (SPECT) system include detector array, electronic system, mechanical system, algorithm for reconstructing with
The subsystems such as man-machine interface.Detector array is generally made up of a series of photomultipliers.The output letter of photomultiplier
Number handled by electronic system, enter after digitlization and rebuild server and carry out image reconstruction.
Electronics subsystem in single photon emission computed tomography (SPECT) system generally include amplification to photomultiplier tube signal,
Shaping, digitlization and digitlization post-treating and other steps.Electronics subsystem in traditional single photon emission computed tomography (SPECT) system
System needs to handle the signal of multiple photomultipliers using substantial amounts of analog circuit, and system scale is larger.
The content of the invention
It is contemplated that at least solving one of above-mentioned technical problem.
Therefore, it is an object of the present invention to propose a kind of processing method of single photon emission tomographic imaging.This method
Fast with speed, parallel processing capability is strong, it is easy to the features such as upgrading, it is adaptable to which Digitized ergonomic single photon emission tomographic imaging is set
Electronics equipment in standby.
Another object of the present invention is to propose a kind of processing system of single photon emission tomographic imaging.
To achieve these goals, the embodiment of the first aspect of the present invention discloses a kind of single photon emission tomographic imaging
Processing method, comprise the following steps:Digitized sampling waveform signal;Input is default can the window upper limit, energy window lower limit and base
Line is biased;Digital baseline is rejected to the digitized wave forms signal according to the baseline offset;Carried from digitized wave forms signal
Took threshold signal;The threshold signal of crossing is summed up, the digital integration of energy is realized;According under the energy window upper limit, energy window
Limit is integrated to the mistake threshold signal after the Integral Processing, obtains complete threshold event excessively.
The processing method of single photon emission tomographic imaging according to embodiments of the present invention, parallel processing energy fast with speed
Power is strong, it is easy to the features such as upgrading.Photomultiplier tube signal after being digitized for single photon emission computed tomography (SPECT) system, Ke Yishi
The functions such as existing signal screening, integration shaping.The method of the embodiment of the present invention can realize signal screening, integration shaping, it is adaptable to
Electronics equipment in Digitized ergonomic single photon emission tomographic imaging equipment.
In addition, the processing method of single photon emission tomographic imaging according to the above embodiment of the present invention can also have it is as follows
Additional technical characteristic:
In some instances, the default energy window upper limit, energy window lower limit and baseline offset are obtained according to experiment.
In some instances, threshold signal was extracted from the digitized wave forms signal, further comprised:Judge the number
Whether word waveform signal continues to exceed predetermined threshold value;If it is, the digitized wave forms signal is crossed into threshold letter as described
Number.
In some instances, the threshold signal of crossing is summed up, realizes the digital integration of energy, further comprise:It is logical
Cross fixed length time integration method or elongated time integration method to sum up the threshold signal of crossing, realize the digital integration of energy;Obtain
Take the multiple peak values for crossing threshold signal.
In some instances, it is described according to it is described can the window upper limit, can window lower limit to crossing threshold after the Integral Processing
Signal is integrated, and is obtained complete threshold event excessively, is further comprised:Judge the mistake threshold signal after the Integral Processing
Whether energy is between the energy window upper limit and the energy window lower limit;If it is, being integrated to the threshold signal of crossing, obtain
Threshold event is crossed to complete, wherein, the threshold event of crossing includes integrating channel address, packet header, energy, timestamp.
The embodiment of second aspect present invention discloses a kind of processing system of single photon emission tomographic imaging, including:Adopt
Egf block, for digitized sampling waveform signal;Input module, for inputting the default energy window upper limit, energy window lower limit and base
Line is biased;Processing module, for rejecting digital baseline to the digitized wave forms signal according to the baseline offset, and from numeral
Change in waveform signal and extracted threshold signal, be integrated processing:The threshold signal of crossing is summed up, the numeral product of energy is realized
Point;And the mistake threshold signal after the Integral Processing is integrated according to the energy window upper limit, energy window lower limit, obtain complete
Cross threshold event.
The processing system of single photon emission tomographic imaging according to embodiments of the present invention, parallel processing energy fast with speed
Power is strong, it is easy to the features such as upgrading.Photomultiplier tube signal after being digitized for single photon emission computed tomography (SPECT) system, Ke Yishi
The functions such as existing signal screening, integration shaping.The method of the embodiment of the present invention can realize signal screening, integration shaping, it is adaptable to
Electronics equipment in Digitized ergonomic single photon emission tomographic imaging equipment.
In addition, the processing system of single photon emission tomographic imaging according to the above embodiment of the present invention can also have it is as follows
Additional technical characteristic:
In some instances, the default energy window upper limit, energy window lower limit and baseline offset are obtained according to experiment.
In some instances, the processing module extracted threshold signal from the digitized wave forms signal, further bag
Include:Judge whether the digitized wave forms signal continues to exceed predetermined threshold value;If it is, the digitized wave forms signal is made
Threshold signal is crossed to be described.
In some instances, the processing module is summed up to the threshold signal of crossing, and is realized the digital integration of energy, is entered
One step includes:The threshold signal of crossing is summed up by fixed length time integration method or elongated time integration method, energy is realized
Digital integration.
In some instances, the processing module according to it is described can the window upper limit, can window lower limit to passing through the Integral Processing
Mistake threshold signal afterwards is integrated, and is obtained complete threshold event excessively, is further comprised:Judge the mistake after the Integral Processing
Whether the energy of threshold signal is between the energy window upper limit and the energy window lower limit;If it is, entering to the threshold signal of crossing
Row is integrated, obtain it is complete cross threshold event, wherein, the threshold event of crossing includes integrating channel address, packet header, energy, timestamp.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Brief description of the drawings
The above-mentioned and/or additional aspect and advantage of the present invention will become from description of the accompanying drawings below to embodiment is combined
Substantially and be readily appreciated that, wherein:
Fig. 1 is the flow chart of the processing method of single photon emission tomographic imaging according to an embodiment of the invention;
Fig. 2 was that threshold criterion illustrates schematic diagram;
Fig. 3 is module status machine transfer block diagram;
Fig. 4 is Integral Processing inside modules logic diagram;
Fig. 5 is afterbody processing logical schematic;
Fig. 6 is truncation schematic diagram;
Fig. 7 is that valid data integrate schematic diagram;
Fig. 8 is that baseline returns schematic diagram.
Embodiment
Embodiments of the invention are described below in detail, the example of the embodiment is shown in the drawings, wherein from beginning to end
Same or similar label represents same or similar element or the element with same or like function.Below with reference to attached
The embodiment of figure description is exemplary, is only used for explaining the present invention, and is not considered as limiting the invention.
In the description of the invention, it is to be understood that term " " center ", " longitudinal direction ", " transverse direction ", " on ", " under ",
The orientation or position relationship of the instruction such as "front", "rear", "left", "right", " vertical ", " level ", " top ", " bottom ", " interior ", " outer " are
Based on orientation shown in the drawings or position relationship, it is for only for ease of the description present invention and simplifies description, rather than indicate or dark
Specific orientation must be had, with specific azimuth configuration and operation by showing the device or element of meaning, therefore it is not intended that right
The limitation of the present invention.In addition, term " first ", " second " are only used for describing purpose, and it is not intended that indicating or implying and be relative
Importance.
In the description of the invention, it is necessary to illustrate, unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected, or be integrally connected;Can
To be mechanical connection or electrical connection;Can be joined directly together, can also be indirectly connected to by intermediary, Ke Yishi
The connection of two element internals.For the ordinary skill in the art, with concrete condition above-mentioned term can be understood at this
Concrete meaning in invention.
With reference to following description and accompanying drawing, it will be clear that these and other aspects of embodiments of the invention.In these descriptions
In accompanying drawing, some particular implementations in embodiments of the invention are specifically disclosed, to represent the implementation for implementing the present invention
Some modes of the principle of example, but it is to be understood that the scope of embodiments of the invention is not limited.On the contrary, the present invention
Embodiment includes the spirit for falling into attached claims and all changes, modification and the equivalent in the range of intension.
The processing method and system of single photon emission tomographic imaging according to embodiments of the present invention are described below in conjunction with accompanying drawing.
Fig. 1 is the flow chart of the processing method of single photon emission tomographic imaging according to an embodiment of the invention.Such as Fig. 1
Shown, the processing method of single photon emission tomographic imaging according to an embodiment of the invention comprises the following steps:
Step S101:Digitized sampling waveform signal.
Step S102:Input is default can the window upper limit, energy window lower limit and baseline offset.
Step S103:Digital baseline is rejected to digitlization waveform signal according to baseline offset.
Step S104:Threshold signal was extracted from digitized wave forms signal.Specifically include:
1st, judge whether digitized wave forms signal continues to exceed predetermined threshold value.
2nd, if it is, regarding digitized wave forms signal as threshold signal excessively.
Step S105:Summed up to crossing threshold signal, realize the digital integration of energy.Specifically include:
1st, the threshold signal of crossing is summed up by fixed length time integration method or elongated time integration method, realizes energy
Digital integration.
2nd, multiple peak values of threshold signal were obtained.
Step S106:The mistake threshold signal after Integral Processing is integrated according to the energy window upper limit, energy window lower limit, obtained
Complete crosses threshold event.Specifically include:
1st, judge the energy of the mistake threshold signal after Integral Processing whether between the energy window upper limit and energy window lower limit.
2nd, if it is, being integrated to crossing threshold signal, obtain it is complete cross threshold event, wherein, cross threshold event including whole
Close channel address, packet header, energy, timestamp.
Specifically, photomultiplier tube signal is amplified and sampled with continuous number, each photomultiplier correspondence
One continuous digitlization sequence, includes the signal level in each sampling period.Signal level sequence after digitlization is connect
Enter in programmable logic controller (PLC), programmable logic controller (PLC) carries out first in first out caching to digital level.Meanwhile, will be to caching
The sequence first entered in queue is handled.
As shown in Fig. 2 the threshold of crossing for carrying out example first sentences choosing:One predetermined threshold value is set, if continuous cross threshold, then right
The signal crossed after threshold is handled.Continuous threshold of crossing judges that the waveform that can ensure threshold all has certain length, rather than makes an uproar
Sound.For different nucleic, probe combination, different numbers can be set.
By cross threshold after signal sequence add and, it is possible to achieve the digital integration of energy.The meaning of digital integration is to obtain letter
Number energy.The mode specifically integrated has two kinds of selections:Fixed length time is integrated with becoming long-time integration.What fixed length time was integrated contains
Justice be the sequence number of integration is set to it is constant, to all signals use identical Integration Strategy.Become containing for long-time integration
Justice is that change of the initial time of integration with the termination time with waveform in itself is relevant.Opened at the waveform for meeting threshold decision condition
Begin integration, and meets the waveform stopping integration from threshold decision condition.
It is similar with crossing threshold decision condition from threshold decision condition.Several continuous waveforms are less than after predetermined threshold value, it is believed that signal
It is over, integration can be stopped.The position of timestamp.
Based on description above, foregoing design is realized based on programmable logic controller (PLC).Programmable logic controller (PLC)
With logic is customizable, processing speed is fast, parallel processing capability is strong, it is easily scalable the characteristics of.Programmable logic controller (PLC) is very
It is adapted to the processing of the photomultiplier output signal in digital human body single photon emission tomographic imaging equipment to multiple passages.
The output signal of each photomultiplier is handled by a corresponding internal logic.Come for this module
Say, enter the digitized wave forms signal that end part is continuous sampling, and the default energy window upper limit, energy window lower limit, baseline offset etc.
Deng.Go out end part be processing, integrate after example energy, timestamp, pipe sequence number, packet header etc..
The overall process logic diagram of the module is as shown in Figure 3:All logic process flows are based on finite state machine.Shape
The jump condition of state machine is as shown in Figure 3.First, module enters init state after upper electricity, is carried out in this state in all
The initialization operation of portion's register.Then module is automatically into Baseline Survey state, in this state, can be as needed to institute
Some waveforms ream a baseline offset.Without other logical process in this state, mainly waiting system is from baseline shape
State was transferred to threshold condition.The judgement for crossing threshold is carried out in this state.Fig. 3 is that module status machine shifts block diagram.
Cross before the condition of threshold and described, system enters the Integral Processing stage after crossing threshold.The Integral Processing stage is core
Heart logical stage, Parallel Implementation energy integral, peak-seeking are with beating the functions such as timestamp, as shown in Figure 4.
The implementation process of each function is described separately below:Integration is to realize that all threshold signals of crossing add and/or fixed length time
It is interior cross threshold signal plus and, and to ensure plus the result of sum will not overflow.Plus the result of sum is preliminary result, the number of occupancy
It is more, it is necessary to give up the invalid bit of afterbody during the truncation in later stage according to digit.
Peak-seeking and the function of beating timestamp logic, which are that searching is all, crosses default position in threshold signal, and records
At the time of to reach, and it is used as using this moment the arrival time of the example.
It is brilliant after each physics example is reached on crystal for digital human body single photon emission tomographic imaging equipment
The visible ray that body is sent can be received by multiple photomultipliers, and respective physics example can be formed in corresponding multiple passages.
After stamping timestamp respectively to the physics example of each passage, the example that can be stabbed by similar time reduces, rebuilds this
Real physics example.
Fig. 4 is Integral Processing inside modules logic diagram.System will enter afterbody processing module after meeting from threshold condition.
Afterbody after afterbody processing module terminates specifically designed for an example is handled.Afterbody processing module is mainly used in small-signal
Compensation.The part that small-signal crosses threshold in itself is just seldom, if using from the strategy for directly terminating integration after threshold, can cause small letter
Number integral result by sampling starting, end position randomness influenceed., can be in signal after mechanism using afterbody processing module
When being reduced to below threshold value, extra integration is carried out.The integral error of small-signal can be reduced.Afterbody processing logic such as Fig. 5 institutes
Show, show that afterbody handles logic.
Following system enters the truncation stage.This stage completes blocking for example energy.After signal integration
Digit is more, and and so many digit need not be used as Energy Efficient position.
As shown in fig. 6, showing truncation.Carry out after truncation state, system has obtained blocking rear example
The timestamp that energy, example are reached.The demand of human body single photon emission tomographic imaging equipment electronics is pressed, can be in effective example
Integrated part carry out once can window screening judgement.If the energy of signal is in the range of preset energy window, then think that this believes
Number it is a useful signal.Then, in addition it is also necessary to add the numbering of the corresponding photomultiplier of this module, the numbering of probe with
And the packet header mark of example.Need these information integrations together, by default logic by these Combination novas into an example
Bag, and mark the example to be surrounded by effect, it is sent in subsequent processing logic.As shown in fig. 7, showing that valid data are integrated.
After effective example integration has been carried out, it is thus necessary to determine that an example is over.The meaning of this part of module exists
In ensuring the integrality of logic.As shown in figure 8, showing that baseline is returned.After good above-mentioned state is confirmed, system mode machine enters
Init state, reset condition is initialised to by the internal register of above-mentioned all logics.Resume waiting for new one and cross threshold example
Arrival.
The processing method of single photon emission tomographic imaging according to embodiments of the present invention, parallel processing energy fast with speed
Power is strong, it is easy to the features such as upgrading.Photomultiplier tube signal after being digitized for single photon emission computed tomography (SPECT) system, Ke Yishi
The functions such as existing signal screening, integration shaping.The method of the embodiment of the present invention can realize signal screening, integration shaping, it is adaptable to
Electronics equipment in Digitized ergonomic single photon emission tomographic imaging equipment.
Further, embodiment of the invention discloses that a kind of processing system of single photon emission tomographic imaging, including:Adopt
Egf block, for digitized sampling waveform signal;Input module, for inputting the default energy window upper limit, energy window lower limit and base
Line is biased;Processing module, for rejecting digital baseline to digitlization waveform signal according to the baseline offset, and from digitized wave
Threshold signal was extracted in shape signal, processing is integrated:The threshold signal of crossing is summed up, the digital integration of energy is realized,
And the mistake threshold signal after the Integral Processing is integrated according to the energy window upper limit, energy window lower limit, obtain complete
Cross threshold event, wherein, it is default can the window upper limit, can window lower limit and baseline offset obtained according to experiment.
In one embodiment of the invention, processing module extracted threshold signal from the digitized wave forms signal, entered
One step includes:Judge whether the digitized wave forms signal continues to exceed predetermined threshold value;If it is, by the digitized wave forms
Signal crosses threshold signal as described.
In one embodiment of the invention, processing module is summed up to the threshold signal of crossing, and realizes the numeral of energy
Integration, further comprises:The threshold signal of crossing is summed up by fixed length time integration method or elongated time integration method, realized
The digital integration of energy;Obtain the multiple peak values for crossing threshold signal.
In one embodiment of the invention, processing module according to it is described can the window upper limit, can window lower limit to passing through the product
Mistake threshold signal after the reason of office is integrated, and is obtained complete threshold event excessively, is further comprised:Judge to pass through the Integral Processing
Whether the energy of mistake threshold signal afterwards is between the energy window upper limit and the energy window lower limit;If it is, crossing threshold to described
Signal is integrated, obtain it is complete cross threshold event, wherein, it is described cross threshold event include integrating channel address, packet header, energy,
Timestamp.
The processing system of single photon emission tomographic imaging according to embodiments of the present invention, parallel processing energy fast with speed
Power is strong, it is easy to the features such as upgrading.Photomultiplier tube signal after being digitized for single photon emission computed tomography (SPECT) system, Ke Yishi
The functions such as existing signal screening, integration shaping.The method of the embodiment of the present invention can realize signal screening, integration shaping, it is adaptable to
Electronics equipment in Digitized ergonomic single photon emission tomographic imaging equipment.
It should be noted that the specific implementation of the processing system of the single photon emission tomographic imaging of the embodiment of the present invention
It is similar with the specific implementation of the processing method of the single photon emission tomographic imaging of the embodiment of the present invention, specifically refer to this hair
The description of the processing method part of the single photon emission tomographic imaging of bright embodiment, in order to reduce redundancy, is not repeated.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means to combine specific features, structure, material or the spy that the embodiment or example are described
Point is contained at least one embodiment of the present invention or example.In this manual, to the schematic representation of above-mentioned term not
Necessarily refer to identical embodiment or example.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that:Not
In the case of departing from the principle and objective of the present invention a variety of change, modification, replacement and modification can be carried out to these embodiments, this
The scope of invention is by claim and its equivalent limits.
Claims (10)
1. a kind of processing method of single photon emission tomographic imaging, it is characterised in that comprise the following steps:
Digitized sampling waveform signal, obtains digitized wave forms signal;
Input is default can the window upper limit, energy window lower limit and baseline offset;
Digital baseline is rejected to the digitized wave forms signal according to the baseline offset;
Threshold signal was extracted from digitized wave forms signal;
The threshold signal of crossing is summed up, the digital integration of energy is realized;
The mistake threshold signal after the Integral Processing is integrated according to the energy window upper limit, energy window lower limit, obtains complete
Cross threshold event.
2. the processing method of single photon emission tomographic imaging according to claim 1, it is characterised in that the default energy
The window upper limit, energy window lower limit and baseline offset are obtained according to experiment.
3. the processing method of single photon emission tomographic imaging according to claim 1, it is characterised in that described from the number
Threshold signal was extracted in word waveform signal, was further comprised:
Judge whether the digitized wave forms signal continues to exceed predetermined threshold value;
If it is, the digitized wave forms signal is crossed into threshold signal as described.
4. the processing method of single photon emission tomographic imaging according to claim 1, it is characterised in that cross threshold letter to described
Number sum up, realize the digital integration of energy, further comprise:
The threshold signal of crossing is summed up by fixed length time integration method or elongated time integration method, the numeral product of energy is realized
Point;
Obtain the multiple peak values for crossing threshold signal.
5. the processing method of the single photon emission tomographic imaging according to claim any one of 1-4, it is characterised in that described
The mistake threshold signal after the Integral Processing is integrated according to the energy window upper limit, energy window lower limit, complete mistake is obtained
Threshold event, further comprises:
Judge the energy of the mistake threshold signal after the Integral Processing whether in the energy window upper limit and the energy window lower limit
Between;
If it is, being integrated to the threshold signal excessively, complete threshold event excessively is obtained, wherein, the threshold event of crossing includes
Integrate channel address, packet header, energy, timestamp.
6. a kind of processing system of single photon emission tomographic imaging, it is characterised in that including:
Sampling module, for digitized sampling waveform signal, obtains digitized wave forms signal;
Input module, for inputting the default energy window upper limit, energy window lower limit and baseline offset;
Processing module, for rejecting digital baseline to the digitized wave forms signal according to the baseline offset, and from digitlization
Threshold signal was extracted in waveform signal, processing is integrated, the threshold signal of crossing was summed up, the numeral product of energy is realized
Point, and the mistake threshold signal after the Integral Processing is integrated according to the energy window upper limit, energy window lower limit, obtain complete
Cross threshold event.
7. the processing system of single photon emission tomographic imaging according to claim 6, it is characterised in that the default energy
The window upper limit, energy window lower limit and baseline offset are obtained according to experiment.
8. the processing system of single photon emission tomographic imaging according to claim 6, it is characterised in that the processing module
Threshold signal was extracted from the digitized wave forms signal, was further comprised:
Judge whether the digitized wave forms signal continues to exceed predetermined threshold value;
If it is, the digitized wave forms signal is crossed into threshold signal as described.
9. the processing system of single photon emission tomographic imaging according to claim 6, it is characterised in that the processing module
The threshold signal of crossing is summed up, the digital integration of energy is realized, further comprises:
The threshold signal of crossing is summed up by fixed length time integration method or elongated time integration method, the numeral product of energy is realized
Point;
Obtain the multiple peak values for crossing threshold signal.
10. the processing system of the single photon emission tomographic imaging according to claim any one of 6-9, it is characterised in that institute
State processing module to integrate the mistake threshold signal after the Integral Processing according to the energy window upper limit, energy window lower limit, obtain
Threshold event is crossed to complete, is further comprised:
Judge the energy of the mistake threshold signal after the Integral Processing whether in the energy window upper limit and the energy window lower limit
Between;
If it is, being integrated to the threshold signal excessively, complete threshold event excessively is obtained, wherein, the threshold event of crossing includes
Integrate channel address, packet header, energy, timestamp.
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