CN104744237A - 一种2-(4-溴甲基苯基)丙酸制备方法 - Google Patents
一种2-(4-溴甲基苯基)丙酸制备方法 Download PDFInfo
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- CN104744237A CN104744237A CN201510083872.3A CN201510083872A CN104744237A CN 104744237 A CN104744237 A CN 104744237A CN 201510083872 A CN201510083872 A CN 201510083872A CN 104744237 A CN104744237 A CN 104744237A
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- bromomethylphenyl
- propionic acid
- preparation
- phenylpropanenitrile
- acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
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- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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CN201510083872.3A CN104744237B (zh) | 2015-02-16 | 2015-02-16 | 一种2-(4-溴甲基苯基)丙酸制备方法 |
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CN201510083872.3A CN104744237B (zh) | 2015-02-16 | 2015-02-16 | 一种2-(4-溴甲基苯基)丙酸制备方法 |
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CN104744237A true CN104744237A (zh) | 2015-07-01 |
CN104744237B CN104744237B (zh) | 2016-08-24 |
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Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105753685A (zh) * | 2016-03-30 | 2016-07-13 | 浙江丽水有邦新材料有限公司 | 一种洛索洛芬中间体的制备方法 |
CN106866404A (zh) * | 2017-01-04 | 2017-06-20 | 昆山力田医化科技有限公司 | 一种4‑溴甲基异苯丙酸的合成方法 |
CN107573230A (zh) * | 2017-08-11 | 2018-01-12 | 重庆沃肯精细化工有限公司 | 一种对溴甲基苯丙酸的合成方法 |
CN105037139B (zh) * | 2015-07-07 | 2018-04-17 | 浙江博聚新材料有限公司 | 一种2‑苯基丙酸制备方法 |
CN109180470A (zh) * | 2018-09-10 | 2019-01-11 | 浙江大学 | 液相循环法制备2-(4-溴甲基苯基)丙酸 |
CN109180464A (zh) * | 2018-09-10 | 2019-01-11 | 浙江大学 | 气相循环法制备2-(4-溴甲基苯基)丙酸 |
CN109438285A (zh) * | 2018-11-06 | 2019-03-08 | 浙江大学 | 基于加压精馏技术的苯乙腈甲基化方法 |
CN109485556A (zh) * | 2018-10-19 | 2019-03-19 | 浙江大学 | 一锅法合成2-苯基丙酸的方法 |
CN109912399A (zh) * | 2019-03-01 | 2019-06-21 | 浙江大学 | 高压合成2-苯基丙酸的方法 |
CN110872235A (zh) * | 2018-08-30 | 2020-03-10 | 江苏瑞科医药科技有限公司 | 一种用新型的碳酸二甲酯甲基化催化剂在制备α-甲基苯乙酸中的应用 |
EP4151616A4 (en) * | 2021-04-26 | 2023-12-20 | Mitsubishi Gas Chemical Company, Inc. | COMPOUND AND METHOD FOR PRODUCING THEREOF |
Citations (2)
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---|---|---|---|---|
US6013832A (en) * | 1997-07-04 | 2000-01-11 | Kolon Industries, Inc. | Process for the production of benzene derivatives |
CN101412670A (zh) * | 2007-10-19 | 2009-04-22 | 浙江普洛医药科技有限公司 | 洛索洛芬钠的合成方法 |
-
2015
- 2015-02-16 CN CN201510083872.3A patent/CN104744237B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6013832A (en) * | 1997-07-04 | 2000-01-11 | Kolon Industries, Inc. | Process for the production of benzene derivatives |
CN101412670A (zh) * | 2007-10-19 | 2009-04-22 | 浙江普洛医药科技有限公司 | 洛索洛芬钠的合成方法 |
Non-Patent Citations (1)
Title |
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TUNDO, PIETRO,ET AL.: "Mono-C-methylation of arylacetonitriles and methyl arylacetates by dimethyl carbonate: a general method for the synthesis of pure 2-arylpropionic acids. 2-phenylpropionic acid", 《ORGANIC SYNTHESES》, vol. 76, 31 December 1999 (1999-12-31), pages 169 - 172 * |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105037139B (zh) * | 2015-07-07 | 2018-04-17 | 浙江博聚新材料有限公司 | 一种2‑苯基丙酸制备方法 |
CN105753685A (zh) * | 2016-03-30 | 2016-07-13 | 浙江丽水有邦新材料有限公司 | 一种洛索洛芬中间体的制备方法 |
CN106866404A (zh) * | 2017-01-04 | 2017-06-20 | 昆山力田医化科技有限公司 | 一种4‑溴甲基异苯丙酸的合成方法 |
CN107573230A (zh) * | 2017-08-11 | 2018-01-12 | 重庆沃肯精细化工有限公司 | 一种对溴甲基苯丙酸的合成方法 |
CN107573230B (zh) * | 2017-08-11 | 2021-09-14 | 重庆沃肯精细化工有限公司 | 一种对溴甲基苯丙酸的合成方法 |
CN110872235A (zh) * | 2018-08-30 | 2020-03-10 | 江苏瑞科医药科技有限公司 | 一种用新型的碳酸二甲酯甲基化催化剂在制备α-甲基苯乙酸中的应用 |
CN109180464A (zh) * | 2018-09-10 | 2019-01-11 | 浙江大学 | 气相循环法制备2-(4-溴甲基苯基)丙酸 |
CN109180470B (zh) * | 2018-09-10 | 2021-02-02 | 浙江大学 | 液相循环法制备2-(4-溴甲基苯基)丙酸 |
CN109180470A (zh) * | 2018-09-10 | 2019-01-11 | 浙江大学 | 液相循环法制备2-(4-溴甲基苯基)丙酸 |
CN109485556A (zh) * | 2018-10-19 | 2019-03-19 | 浙江大学 | 一锅法合成2-苯基丙酸的方法 |
CN109438285A (zh) * | 2018-11-06 | 2019-03-08 | 浙江大学 | 基于加压精馏技术的苯乙腈甲基化方法 |
CN109912399A (zh) * | 2019-03-01 | 2019-06-21 | 浙江大学 | 高压合成2-苯基丙酸的方法 |
EP4151616A4 (en) * | 2021-04-26 | 2023-12-20 | Mitsubishi Gas Chemical Company, Inc. | COMPOUND AND METHOD FOR PRODUCING THEREOF |
US11919833B2 (en) | 2021-04-26 | 2024-03-05 | Mitsubishi Gas Chemical Company, Inc. | Compound and method for producing same |
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CN104744237B (zh) | 2016-08-24 |
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Inventor after: Zhou Minghe Inventor before: Gong Huayin Inventor before: Zhou Jun Inventor before: Zhou Bangfu |
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Effective date of registration: 20160622 Address after: 323000 Zhejiang province Tongji street Lishui Shuige Industrial Zone No. 19 Applicant after: ZHEJIANG BOADGE CHEMICAL CO., LTD. Address before: 323000 Zhejiang province Tongji street Lishui Shuige Industrial Zone No. 19 Applicant before: Lishui Nanming Chemical Co., Ltd. |
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