CN104689260B - It is a kind of to treat breast cancer and the Chinese medicine preparation of endocrinotherapy for breast cancer side effect be improved - Google Patents
It is a kind of to treat breast cancer and the Chinese medicine preparation of endocrinotherapy for breast cancer side effect be improved Download PDFInfo
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Abstract
Treat breast cancer the present invention relates to a kind of and the Chinese medicine composition of endocrinotherapy for breast cancer side effect can be improved.The Chinese medicine composition is prepared from by the bulk drug of following parts by weight：5 15 parts of stir-baked RADIX BUPLEURI with vinegar, 5 15 parts of root tuber of aromatic turmeric, 5 15 parts of Asian puccoon, 5 15 parts of moutan bark, 5 15 parts of the root bark of Chinese wolf-berry, 5 15 parts of the root of herbaceous peony, 5 15 parts of the fruit of Chinese magnoliavine, 10 30 parts of light wheat.Above-mentioned each bulk drug can farthest play drug effect, and easypro liver cool blood is played altogether, and relieving restlessness hidroschesis adjusts negative and positive, the work(treated both principal and secondary aspect of disease, it is possible to increase immunity of human body itself, regulation nervous system；And human body is not produced any toxic side effects, safely and effectively, the symptoms such as hectic fever caused by endocrinotherapy for breast cancer can be improved.The present invention provides one kind safely, effectively for prior art, and Chinese medicine composition of with low cost, the preparation technology easy-to-use for treating breast cancer.
Description
Technical field
The invention belongs to field of medicaments, and in particular to a kind of to treat Chinese medicine composition of breast cancer and preparation method thereof.
Background technology
No matter in the world or China, the incidence of disease of breast cancer occupies the first place of female cancer morbidity.WHO GLOBOCAN
2012 statistical result showeds：Pathogenesis of breast carcinoma number of cases is 1,700,000, accounts for the 11.9% of all tumours；Chinese oncology annual statistics
2010 annual datas：Breast cancer incidence is 25.28/10 ten thousand, accounts for the 16.2% of all tumours.Therefore, breast cancer is a kind of serious
Influence the disease of the physically and mentally healthy even threat to life of women.Breast cancer refer to breast ductal epithelial cells it is various it is inside and outside it is carcinogenic because
In the presence of element, cell loses normal characteristic and paraplasm, so that the disease of canceration occurs more than the limit of self-regeneration.
Its earliest performance is to suffer from breast and single-shot, form occur to be partial to circular, ellipse or the small lump of irregular shape, quality typically compared with
Firmly, indefinite border；A few patients can have distending pain, dull pain.The morbidity of breast cancer is often relevant with heredity, and between 40-60 Sui, absolutely
Women's incidence of disease before and after menstrual period is higher.The cause of disease of breast cancer is also without completely clearly, but bearing status, oral contraceptive, something lost
The factors such as biography factor, ionising radiation, unsound eating habit be identified with it is breast cancer related.
The method of existing treatment breast cancer is a lot, mainly including operative treatment, chemicotherapy, endocrine therapy and targeted therapy
Deng.In patient with breast cancer, about 60%~75% is estrogen receptor positive (ER+) breast cancer, and thus endocrine therapy turns into
The major way of breast cancer treatment, and endocrine therapy can also bring some unfavorable side effects to patient, at about 80% mouthful
The patient of TAM is taken, about 58% takes the symptoms such as hectic fever, agitation occurs in the patient of arimedex；And due to
Duration is long, and symptom substantially, therefore has had a strong impact on the life quality of patient.
Mammary gland, faints belonging to cloudy Liver Channel, its pathogenesis：Inernal injuries caused by seven emotions, the melancholy impariment of the liver, heat resulting from stagnation of QI, evil poison is pented up, and is caused
Body function is disorderly, liver-spleen disharmony, causes blockage of main and collateral channels, qi depression to blood stasis, coalescence nucleation.Traditional Chinese medicine is the exclusive medical treatment of China
Advantage, more and more clinical evidences support traditional Chinese medicine to reduce the side effect of breast cancer chemicotherapy and endocrine therapy, not only
Physical recovery can be promoted, can also strengthen the body function of patient.Therefore, develop and develop effective Chinese medicine preparation treatment mammary gland
Cancer, is of great significance to the hygiene medical treatment cause tool of China.The present inventor is groped and creative by substantial amounts of experiment
Work, provides a kind of Chinese medicine composition of effective treatment breast cancer for patient with breast cancer, can significantly improve endocrine therapy
The side effects such as caused hectic fever, its pharmacodynamics and clinical trial result are extremely notable.
The content of the invention
The rules for the treatment of of the invention from Chinese traditional treatment breast cancer, by development test, by stir-baked RADIX BUPLEURI with vinegar, root tuber of aromatic turmeric, Asian puccoon, tree peony
Skin, the root bark of Chinese wolf-berry, the root of herbaceous peony, the fruit of Chinese magnoliavine, the taste bulk drug of light wheat eight, through suitable processing, extract, one kind have been made and has treated mammary gland
Cancer, and the Chinese medicine composition of hectic fever caused by can effectively improve endocrine agents.
According to an aspect of the invention, there is provided a kind of Chinese medicine composition for treating breast cancer, it is by following weight parts
Bulk drug be prepared from：5-15 parts of stir-baked RADIX BUPLEURI with vinegar, 5-15 parts of root tuber of aromatic turmeric, 5-15 parts of Asian puccoon, 5-15 parts of moutan bark, root bark of Chinese wolf-berry 5-15
Part, 5-15 parts of the root of herbaceous peony, 5-15 parts of the fruit of Chinese magnoliavine, 10-30 parts of light wheat.
In a preferred embodiment, the Chinese medicine composition is prepared from by the bulk drug of following parts by weight：Vinegar
9 parts of radix bupleuri, 10 parts of root tuber of aromatic turmeric, 10 parts of Asian puccoon, 9 parts of moutan bark, 9 parts of the root bark of Chinese wolf-berry, 10 parts of the root of herbaceous peony, 10 parts of the fruit of Chinese magnoliavine, 20 parts of light wheat.
According to another aspect of the present invention there is provided the preparation method of the Chinese medicine composition, it comprises the following steps：
(1) according to the proportioning of above-mentioned Chinese medicine composition weigh bulk drug stir-baked RADIX BUPLEURI with vinegar, root tuber of aromatic turmeric, Asian puccoon, moutan bark, the root bark of Chinese wolf-berry,
The root of herbaceous peony, the fruit of Chinese magnoliavine and light wheat, it is standby；
(2) after the bulk drug in step (1) is soaked, then high heat decoction is cooked by slow fire, and filtrate is obtained after filtering
And the dregs of a decoction；
(3) dregs of a decoction resulting in step (2) are added water into carry out high heat decoction, is then cooked by slow fire, is obtained after filtering
Filtrate and filter residue；
(4) merge filtrate twice, the Chinese medicine composition of the treatment breast cancer is produced after being concentrated and dried.
Preferably, the preparation method of Chinese medicine composition of the present invention comprises the following steps：
(1) according to the proportioning of above-mentioned Chinese medicine composition weigh bulk drug stir-baked RADIX BUPLEURI with vinegar, root tuber of aromatic turmeric, Asian puccoon, moutan bark, the root bark of Chinese wolf-berry,
The root of herbaceous peony, the fruit of Chinese magnoliavine and light wheat, crush, mixing for standby use；
(2) bulk drug in step (1) was soaked after 20-60 minutes, fried by intense fire with the 5-12 times of water measured after boiling,
To be cooked by slow fire 20-45 minutes, filtrate and the dregs of a decoction are obtained after cooling, filtering；
(3) dregs of a decoction resulting in step (2) are fried by intense fire with the 3-8 times of water measured again after boiling, to be cooked by slow fire 20-45
Minute, obtain filtrate and filter residue after cooling, filtering；
(4) merge filtrate twice, concentrate and produce after drying the Chinese medicine composition of the treatment breast cancer.
It is further preferred that the preparation method of Chinese medicine composition of the present invention comprises the following steps：
(1) according to the proportioning of above-mentioned Chinese medicine composition weigh bulk drug stir-baked RADIX BUPLEURI with vinegar, root tuber of aromatic turmeric, Asian puccoon, moutan bark, the root bark of Chinese wolf-berry,
The root of herbaceous peony, the fruit of Chinese magnoliavine and light wheat, crush, mixing for standby use；
(2) bulk drug in step (1) was soaked after 30 minutes, fried by intense fire with the water of 8 times of amounts after boiling, with slow fire
Decoct 30 minutes, filtrate and the dregs of a decoction are obtained after cooling, filtering；
(3) dregs of a decoction resulting in step (2) are fried by intense fire with the water of 5 times of amounts again after boiling, to be cooked by slow fire 30 minutes,
Filtrate and filter residue are obtained after cooling, filtering；
(4) merge filtrate twice, concentrate and produced after spray-dried the Chinese medicine composition of the treatment breast cancer.
In a preferred embodiment, the Chinese medicine composition is decoction.
In another preferred embodiment, can be according to the conventional preparation method in this area, by adding in right amount
Auxiliary material, the system such as tablet, granule, capsule, soft extract, pill, bitter edible plant agent, powder, dripping pill is made by the Chinese medicine composition of the present invention
Agent.
The auxiliary material includes field of medicaments various auxiliary materials conventional and general in above-mentioned production process is prepared.
According to another aspect of the invention, the medical usage of the Chinese medicine composition is additionally provided.Chinese traditional medicine composition of the present invention
The instructions of taking of thing：It is decocted in water for oral dose, daily 1 dose, a point morning and evening takes twice, even served 30 days for a course for the treatment of.Clinical and pharmacology is real
Test result to show, traditional Chinese medicine composition for treating breast cancer effect of the invention substantially, has no toxic side effect, enable in particular to significantly improve in
The side effects such as the hectic fever caused by secretion treatment, effective percentage reaches more than 70%.For clinically breast cancer treatment open it is new
Road, with important social value.
The meridian distribution of property and flavor and major function of each taste Chinese medicine are as follows in Chinese medicine composition of the present invention：
Stir-baked RADIX BUPLEURI with vinegar, bitter in taste, be slightly cold, Return liver, gallbladder channel.Radix bupleuri have with inducing diaphoresis, the effect of soothing the liver rising Yang.For hair of catching a cold
Heat, fevers and chills alternate, malaria, stagnation of QI due to depression of the liver, sternal rib pain, the prolapse of uterus, irregular menstruation.Its disperse function can be reduced after vinegar system.
Root tuber of aromatic turmeric, pungent, hardship is cold in nature.Return liver, the heart, lung channel.Stop with regulating qi to disperse stagnation, heart fire-clearing upset-relieving, normalizing gallbladder to cure jaundice, promoting blood circulation
Bitterly, promoting qi circulation and removing obstruction in the collateral, the cool blood that clears away heart-fire are used.
Asian puccoon, it is bitter, cold.Enter percardium, Liver Channel.With cool blood, promoting blood circulation, heat-clearing, effect of removing toxic substances.Available for treatment warm
Macula, jaundice with damp-heat pathogen, purpura tells, is defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, the disease such as large carbuncle.
Moutan bark, it is bitter, pungent, be slightly cold, the thoughts of returning home, liver and kidney channel, with clearing heat and cooling blood, activate blood circulation and disperse blood clots, reducing the asthenic fever the effects such as.
The root bark of Chinese wolf-berry, it is sweet, light, tremble with fear, enter lung kidney channel.Clearing heat and cooling blood, reducing the asthenic fever.The root bark of Chinese wolf-berry enters blood system and cool blood, is good at moving back
Abnormal heat.To fever due to yin deficiency, continuous low fever is particularly suitable.
The root of herbaceous peony, it is cool in nature, bitter acid, be slightly cold, with blood-supplementing blood-nourishing, suppressing liver-YANG, soft liver analgesic, astringing YIN to stop sweating the effects such as,
It is anxious suitable for fever due to yin deficiency, irregular menstruation, chest and abdomen pain over the hypochondriac region, four limbs contraction, diarrhea dysentery abdominal pain, spontaneous sweating, uterine bleeding, with inferior
Disease.
The fruit of Chinese magnoliavine, is astringed the lung, and nourshing kidney is promoted the production of body fluid, and receives sweat, puckery essence.Control the deficiency syndrome of the lung to breath with cough, thirst, spontaneous perspiration, night sweat, internal lesion caused by overexertion is thin
It is thin, emission, protracted dysentery and diarrhea.
Light wheat, it is sweet, it is cool in nature.Thoughts of returning home warp.Except abnormal heat, hidroschesis.For hectic fever due to yin labor heat, spontaneous sweating.
Beneficial effects of the present invention：
The present invention is based on the traditional Chinese medical science and carries out the dialectical principle treated to treatment breast cancer, and breast cancer belongs to traditional Chinese medicine
The category such as " newborn ruffian ", " mammary cancer ", and be a kind of systemic disease, it is the local clinical performance of general disease.The present invention according to
Cure mainly as monarch, the auxiliary combination principle controlled as minister, root tuber of aromatic turmeric, Asian puccoon liver cool blood of relaxing are monarch drug in a prescription, and stir-baked RADIX BUPLEURI with vinegar auxiliary root tuber of aromatic turmeric is soothing the liver, radix bupleuri vinegar
Its disperse function is reduced after system, while priming enter liver is to make.Moutan bark, root bark of Chinese wolf-berry auxiliary Asian puccoon cool blood are except steaming, and moutan bark enters blood
Point return liver warp, the kind heat purified the blood point.The root bark of Chinese wolf-berry is clearind deficient heat, to have controlled the hectic fever due to yin good merchantable brand of sweat.Root of herbaceous peony suppressing liver-YANG, holds back the moon and stops
Sweat.Fruit of Chinese magnoliavine nourishing generate fluid, calming heart arrest sweating, the sour warm-natured cool property to help the Asian puccoon root bark of tree peony.Light wheat sweet taste and relieving restlessness hidroschesis
Zhi Laore, can auxiliary root of herbaceous peony fruit of Chinese magnoliavine hidroschesis relieving restlessness, auxiliary moutan bark root bark of Chinese wolf-berry reducing the asthenic fever.
Meanwhile, occur after patient with breast cancer's endocrine therapy flushed face, warm, perspire, the symptom such as agitation, in
Cure the understanding and the dialectical category liver depression blood-head of Hot flash symptoms to breast cancer.The present invention is using liver cool blood of relaxing as the main rules for the treatment of, by near
The Clinical and experimental study of 10 years, summarize soothing the liver cool blood side treatment endocrinotherapy for breast cancer caused by Hot flash symptoms, receive
Preferable clinical efficacy.
As can be seen here, each bulk drug of the invention is mutually coordinated can farthest play drug effect together, and easypro liver is played altogether
Cool blood, relieving restlessness hidroschesis adjusts negative and positive, the work(treated both principal and secondary aspect of disease, it is possible to increase immunity of human body itself, regulation nervous system.Also,
The Chinese medicine composition of the present invention does not produce any toxic side effects, safely and effectively to human body, can improve endocrinotherapy for breast cancer
The symptoms such as caused hectic fever.Therefore, the present invention provides one kind safely, effectively for prior art, and with low cost, preparation technology
Easy-to-use is used for the Chinese medicine composition for treating breast cancer.
Specific embodiment
Technical scheme is further described by implementation below.It is pointed out that following explanation
Only to claimed technical scheme for example, not any limitation to these technical schemes.This hair
Bright protection domain is defined by the content that appended claims are recorded.
Embodiment 1
A kind of Chinese medicine composition for treating breast cancer, it is prepared from by the bulk drug of following weight：
Stir-baked RADIX BUPLEURI with vinegar 9g, root tuber of aromatic turmeric 10g, Asian puccoon 10g, moutan bark 9g, root bark of Chinese wolf-berry 9g, root of herbaceous peony 10g, fruit of Chinese magnoliavine 10g, light wheat
20g。
The preparation method of the Chinese medicine composition, is comprised the following steps that：
(1) according to the proportioning of above-mentioned Chinese medicine composition weigh bulk drug stir-baked RADIX BUPLEURI with vinegar, root tuber of aromatic turmeric, Asian puccoon, moutan bark, the root bark of Chinese wolf-berry,
The root of herbaceous peony, the fruit of Chinese magnoliavine and light wheat, crush, mixing for standby use；
(2) bulk drug in step (1) was soaked after 30 minutes, fried by intense fire with 800ml water after boiling, with slow fire
Decoct 30 minutes, filtrate and the dregs of a decoction are obtained after cooling, filtering；
(3) dregs of a decoction resulting in step (2) are fried by intense fire with 500ml water again after boiling, to be cooked by slow fire 30 minutes,
Filtrate and filter residue are obtained after cooling, filtering；
(4) merge filtrate twice, concentrate and produced after spray-dried the Chinese medicine composition of the treatment breast cancer.
The instructions of taking of the Chinese medicine composition is：One portion per day, a point morning and evening takes twice, is within 30 days a course for the treatment of.
Embodiment 2
A kind of Chinese medicine composition for treating breast cancer, it is prepared from by the bulk drug of following weight：
It is stir-baked RADIX BUPLEURI with vinegar 15g, root tuber of aromatic turmeric 15g, Asian puccoon 15g, moutan bark 15g, root bark of Chinese wolf-berry 15g, root of herbaceous peony 15g, fruit of Chinese magnoliavine 15g, floating small
Wheat 30g.
The preparation method of the Chinese medicine composition, is comprised the following steps that：
(1) according to the proportioning of above-mentioned Chinese medicine composition weigh bulk drug stir-baked RADIX BUPLEURI with vinegar, root tuber of aromatic turmeric, Asian puccoon, moutan bark, the root bark of Chinese wolf-berry,
The root of herbaceous peony, the fruit of Chinese magnoliavine and light wheat, crush, mixing for standby use；
(2) bulk drug in step (1) was soaked after 60 minutes, fried by intense fire with 1600ml water after boiling, with text
Fire is decocted 40 minutes, and filtrate and the dregs of a decoction are obtained after cooling, filtering；
(3) dregs of a decoction resulting in step (2) are fried by intense fire with 1000ml water again after boiling, to be cooked by slow fire 35 points
Clock, filtrate and filter residue are obtained after cooling, filtering；
(4) merge filtrate twice, concentrate and produced after spray-dried the Chinese medicine composition of the treatment breast cancer.
The instructions of taking of the Chinese medicine composition is：One portion per day, a point morning and evening takes twice, is within 30 days a course for the treatment of.
Embodiment 3
A kind of Chinese medicine composition for treating breast cancer, it is prepared from by the bulk drug of following weight：
Stir-baked RADIX BUPLEURI with vinegar 5g, root tuber of aromatic turmeric 5g, Asian puccoon 5g, moutan bark 5g, root bark of Chinese wolf-berry 5g, root of herbaceous peony 5g, fruit of Chinese magnoliavine 5g, light wheat 10g.
The preparation method of the Chinese medicine composition, is comprised the following steps that：
(1) according to the proportioning of above-mentioned Chinese medicine composition weigh bulk drug stir-baked RADIX BUPLEURI with vinegar, root tuber of aromatic turmeric, Asian puccoon, moutan bark, the root bark of Chinese wolf-berry,
The root of herbaceous peony, the fruit of Chinese magnoliavine and light wheat, crush, mixing for standby use；
(2) bulk drug in step (1) was soaked after 20 minutes, fried by intense fire with 300ml water after boiling, with slow fire
Decoct 25 minutes, filtrate and the dregs of a decoction are obtained after cooling, filtering；
(3) dregs of a decoction resulting in step (2) are fried by intense fire with 200ml water again after boiling, to be cooked by slow fire 20 minutes,
Filtrate and filter residue are obtained after cooling, filtering；
(4) merge filtrate twice, concentrate and produced after spray-dried the Chinese medicine composition of the treatment breast cancer.
The instructions of taking of the Chinese medicine composition is：One portion per day, a point morning and evening takes twice, is within 30 days a course for the treatment of.
The anticancer experiment in vitro of the Chinese medicine composition of the present invention of embodiment 4
Using classical cytotoxic activity vitro detection method mtt assay, test sample is to the human tumor cells of in vitro culture
Cell breeds toxicity.
Sample adds water ultrasonic extraction during experiment, and centrifugation removes undissolved part, institute is diluted to RPMI1640 culture mediums
Need concentration.
Cell line：MCF-7 Breast Cancer Cell.
Experimental method：
Experiment uses routine MTT detection methods.Inoculating cell：Take the logarithm growth period cell, digested through 0.25% pancreatin
The RPMI-1640 nutrient solutions containing 10% hyclone are added afterwards, cell is diluted to single cell suspension, are adjusted cell number, are connect
Plant in 96 orifice plates, per the μ L of hole 100.Cell after inoculation is put 37 DEG C, cultivated 24 hours in 5% CO2gas incubator.Dosing：
Test medicine is subjected to doubling dilution with RPMI-1640 nutrient solutions, 6 concentration are configured altogether, is added in 96 orifice plates, 100 μ L/ holes.
Each sample concentration sets 4 multiple holes, with the RPMI-1640 nutrient solutions of not composite medicine as a control group.Cell is put 37 after sample-adding
DEG C, continue in 5% CO2gas incubator to cultivate 48 hours.Plus MTT：Supernatant is abandoned, adds 10 μ L plus MTT (5mg/ml) per hole,.Put
37 DEG C are continued to take out after cultivating 4 hours.Survey OD values：Supernatant in the orifice plate of reject 96, the μ L of DMSO 100 are added per hole.In enzyme mark
Instrument 570nm determines OD values, and inhibitory rate of cell growth is calculated with following formula：
Inhibiting rate=[(1- medications group mean OD value/control group mean OD value)] × 100%
Experimental result：
The inhibitory action such as following table of Chinese medicine composition prepared by embodiment 1-3 to the MCF-7 Breast Cancer Cell of in vitro culture
It is shown：
Table 1
According to above in vitro test result, Chinese medicine composition prepared by 1-3 of the embodiment of the present invention is to MCF-7 Breast Cancer Cell
Significant inhibitory action is respectively provided with, maximum concentration (30mg/ml) its inhibiting rate reaches more than 95%.
Inhibitory action of the Chinese medicine composition of the present invention of embodiment 5 to transplanted breast carcinoma
1st, experimental animal and knurl strain
Female sex-health Balb/c nude mices, body weight 18-22g in 6-8 weeks mouse age, the magnificent animal center of tonneau is tieed up purchased from Beijing；People
Breast cancer cell line mcf-7 is purchased from U.S.'s ATCC cell centres.
2nd, modeling and experimental method
Balb/c nude mices adaptability is raised.The exponential phase MCF-7 breast cancer cells of in vitro culture are taken, cell concentration is adjusted
Whole is 1 × 107/ml.Under aseptic condition, cell is inoculated in the right armpit of nude mice subcutaneous, inoculum concentration be 0.2ml/ (cell number is
2×106/ only).Whole seeded process must be carried out with sterile working in aseptic cover, and inoculation is completed in 1h.
Periodic measurement tumour after inoculation, treats that gross tumor volume reaches 50~100mm3, at random by the Balb/c nude mices of lotus knurl point
For 6 groups, every group 10, respectively tumor model control group, Chinese medicine put forward composition group (5g/kg) (embodiment 1-3), the 5-Fu positives
Control group.The daily gavage of test group gives Chinese medicine composition, and dosage is 5g/kg, and tumor model control group gavage is given in equal volume
The aqueous solution, 5-Fu control groups are injected intraperitoneally by solvent of physiological saline, and dosage is 20mg/kg, weekly administration 1 time.Test period
For 21d, next day after last dose, observed as follows：
Completely strip tumor mass, and calculating tumor control rate of weighing, tumor control rate=(control group tumor weight-treatment group
Tumor weight)/control group tumor weight × 100%
3rd, experimental result：
The inhibitory action of Chinese medicine composition prepared by embodiment 1-3 to Implanted breast cancer in mouse：5g/kg Chinese medicine compositions
The growth (P ＜ 0.01) of Implanted breast cancer in mouse can be significantly inhibited, its anti-breast cancer activity is higher than chemotherapeutic 5-fluor-uracil.
It is shown in Table 2.
Table 2
The Clinical observation of the Chinese medicine composition of the present invention of embodiment 6
Choose the breast cancer patients for receiving endocrine therapy totally 70 with complete data.It is randomly divided into treatment group 35
Example, control group 35.
1st, inclusive criteria：
(1) through the clear and definite patient with breast cancer of pathological diagnosis；
(2) ERs (ER) and/or progesterone receptor (PR) (+)；
(3) oral tamoxifen and there are Hot flash symptoms daily；
(4) treatment such as non-row chemotherapy, corticosteroid or hormone medicine at present；
(5) Chinese medical discrimination is liver depression blood-head；
(6) blood routine, hepatic and renal function are normal.
2nd, exclude and reject standard：
(1) diabetes, hyperthyroidism and unsteered patients with hypertension；
(2) Patients With Pheochromocytoma；
(3) using the Chinese medicine for having heat-clearing effect；
(4) person of dropping by the wayside.
3rd, treatment method：
All patients in group continue oral tamoxifen (10mg/ pieces).Treatment group takes while TAM is taken
The Chinese medicine composition of embodiment 1, one portion per day takes in the morning and evening in two times, and course for the treatment of is to comment effect after 21 days, a course for the treatment of.
4th, observation index：
(1) hectic fever number of times, degree；
(2) sleep improvement situation.
It is (slight with the menopausal women hectic fever Kupperman stage divisions of international endorsement：≤ 5 times/day, severe：＞ 5 times/
My god) evaluate hectic fever situation.Evaluate the order of severity of sleep disorder symptom with 0~10 point of patient's Self-assessment Scale, 0 point be it is asymptomatic,
10 points of most serious degree for that can imagine.1~3 point is slight, and 4~6 points are moderate, and 7~10 points are severe.In, severe sleep
Uneasiness is sleep-disorder.
Patient records hectic fever frequency, duration for 1 week, whether with sweating and sleep feelings in detail before the test
Condition, whether there is night revival, be used as baseline index.Daily situation is recorded after medication, record sheet is returned and detects that blood is normal within the 21st day
Rule and blood biochemistry situation.
5th, efficacy assessment standard：
With being compared before treatment after being treated, hectic fever be divided into it is unchanged, mitigate (from again to light), disappear (from weight or it is light to
Hectic fever disappears).Sleep is divided into unchanged (still in, severe or hypophypnosis uneasy), (therefrom, severe is to slightly for sleep improvement
Or asymptomatic).
6th, treatment results：Two groups for the treatment of results are as shown in table 3：
Hectic fever caused by the breast cancer patients endocrine therapy of table 3 improves situation and compared
Through Chi-square Test, two groups of effective percentage compare, and difference has very significant (P ＜ 0.01)
The breast cancer patients sleep improvement situation of table 4 compares
Through Chi-square Test, two groups of effective percentage compare, and difference has very significant (P ＜ 0.001).
Present invention merely illustrates some claimed specific embodiments, one of them or more skill
Described technical characteristic can be combined with arbitrary one or more technical schemes in art scheme, and these are combined and obtain
Technical scheme also in the application protection domain, technical scheme is disclosed in the present invention just as obtained from these are combined
It is specific in content to record the same.
Claims (10)
1. a kind of Chinese medicine composition for being used to treat breast cancer, it is characterised in that be prepared from by the bulk drug of following weight parts：
9 parts of stir-baked RADIX BUPLEURI with vinegar, 10 parts of root tuber of aromatic turmeric, 10 parts of Asian puccoon, 9 parts of moutan bark, 9 parts of the root bark of Chinese wolf-berry, 10 parts of the root of herbaceous peony, 10 parts of the fruit of Chinese magnoliavine, light wheat 20
Part.
2. a kind of Chinese medicine composition for being used to treat breast cancer, it is characterised in that be prepared from by the bulk drug of following weight parts：
15 parts of stir-baked RADIX BUPLEURI with vinegar, 15 parts of root tuber of aromatic turmeric, 15 parts of Asian puccoon, 15 parts of moutan bark, 15 parts of the root bark of Chinese wolf-berry, 15 parts of the root of herbaceous peony, 15 parts of the fruit of Chinese magnoliavine, light wheat
30 parts.
3. a kind of Chinese medicine composition for being used to treat breast cancer, it is characterised in that be prepared from by the bulk drug of following weight parts：
5 parts of stir-baked RADIX BUPLEURI with vinegar, 5 parts of root tuber of aromatic turmeric, 5 parts of Asian puccoon, 5 parts of moutan bark, 5 parts of the root bark of Chinese wolf-berry, 5 parts of the root of herbaceous peony, 5 parts of the fruit of Chinese magnoliavine, 10 parts of light wheat.
4. the preparation method of the Chinese medicine composition described in a kind of any one of claim 1-3, it is characterised in that including following step
Suddenly：
(1) according to the proportioning of the Chinese medicine composition weigh bulk drug stir-baked RADIX BUPLEURI with vinegar, root tuber of aromatic turmeric, Asian puccoon, moutan bark, the root bark of Chinese wolf-berry, the root of herbaceous peony,
The fruit of Chinese magnoliavine and light wheat, it is standby；
(2) after the bulk drug in step (1) is soaked, then high heat decoction is cooked by slow fire, and filtrate and medicine are obtained after filtering
Slag；
(3) dregs of a decoction resulting in step (2) are added water into carry out high heat decoction, is then cooked by slow fire, filtrate is obtained after filtering
And filter residue；
(4) merge filtrate twice, the Chinese medicine composition of the treatment breast cancer is produced after being concentrated and dried.
5. preparation method as claimed in claim 4, it is characterised in that comprise the following steps：
(1) according to the proportioning of the Chinese medicine composition weigh bulk drug stir-baked RADIX BUPLEURI with vinegar, root tuber of aromatic turmeric, Asian puccoon, moutan bark, the root bark of Chinese wolf-berry, the root of herbaceous peony,
The fruit of Chinese magnoliavine and light wheat, crush, mixing for standby use；
(2) bulk drug in step (1) was soaked after 20-60 minutes, fried by intense fire with the 5-12 times of water measured after boiling, with text
Fire is decocted 20-45 minutes, and filtrate and the dregs of a decoction are obtained after cooling, filtering；
(3) dregs of a decoction resulting in step (2) are fried by intense fire with the 3-8 times of water measured again after boiling, to be cooked by slow fire 20-45 points
Clock, filtrate and filter residue are obtained after cooling, filtering；
(4) merge filtrate twice, concentrate and produce after drying the Chinese medicine composition of the treatment breast cancer.
6. the preparation method as described in claim 4 or 5, it is characterised in that comprise the following steps：
(1) according to the proportioning of the Chinese medicine composition weigh bulk drug stir-baked RADIX BUPLEURI with vinegar, root tuber of aromatic turmeric, Asian puccoon, moutan bark, the root bark of Chinese wolf-berry, the root of herbaceous peony,
The fruit of Chinese magnoliavine and light wheat, crush, mixing for standby use；
(2) bulk drug in step (1) was soaked after 30 minutes, fried by intense fire with the water of 8 times of amounts after boiling, to be cooked by slow fire
30 minutes, filtrate and the dregs of a decoction are obtained after cooling, filtering；
(3) dregs of a decoction resulting in step (2) are fried by intense fire with the water of 5 times of amounts again after boiling, it is cold to be cooked by slow fire 30 minutes
But filtrate and filter residue are obtained after, filtering；
(4) merge filtrate twice, concentrate and produced after spray-dried the Chinese medicine composition of the treatment breast cancer.
7. the Chinese medicine composition as described in claim any one of 1-3, it is characterised in that the Chinese medicine composition is decoction.
8. the Chinese medicine composition as described in claim any one of 1-3, it is characterised in that add pharmaceutically conventional auxiliary material by institute
State Chinese medicine composition and prepare piece agent, granule, capsule, soft extract, pill, medicinal tea, powder or dripping pill.
9. purposes of the Chinese medicine composition in the medicine for preparing treatment breast cancer described in a kind of any one of claim 1-3.
10. a kind of tide caused by improvement endocrinotherapy for breast cancer is prepared of the Chinese medicine composition described in any one of claim 1-3
Purposes in the medicine of heat.
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| CN201510163440.3A CN104689260B (en) | 2015-04-08 | 2015-04-08 | It is a kind of to treat breast cancer and the Chinese medicine preparation of endocrinotherapy for breast cancer side effect be improved |
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| CN201510163440.3A CN104689260B (en) | 2015-04-08 | 2015-04-08 | It is a kind of to treat breast cancer and the Chinese medicine preparation of endocrinotherapy for breast cancer side effect be improved |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101394892A (en) * | 2006-01-12 | 2009-03-25 | 莫里艾克私人有限公司 | Composition for treating or preventing hot flashes and use thereof |
| CN101513508A (en) * | 2008-02-22 | 2009-08-26 | 北京天科仁祥医药科技有限公司 | Chinese medicament for treating breast cancer, and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101394892A (en) * | 2006-01-12 | 2009-03-25 | 莫里艾克私人有限公司 | Composition for treating or preventing hot flashes and use thereof |
| CN101513508A (en) * | 2008-02-22 | 2009-08-26 | 北京天科仁祥医药科技有限公司 | Chinese medicament for treating breast cancer, and preparation method thereof |
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