CN104799118A - Dog food and preparation method thereof - Google Patents
Dog food and preparation method thereof Download PDFInfo
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Abstract
The invention discloses dog food and a preparation method thereof. The dog food comprises the following raw materials of wheat, black sesame seed powder, lotus root starch, mussel, taro meal, pumpkin powder, oranges, bananas, duck meat, black fungus, tomatoes, grapes, mulberry, longan pulp, litchi, black soya bean, vitamin premix and trace element premix. The dog food disclosed by the invention has the beneficial effects that the dog food contains traditional Chinese medicine additives with the functions of nourishing yin to lessen fire, cooling blood and eliminating toxins, and tonifying qi and strengthening the body resistance; when the dog food containing the traditional Chinese medicine additives is specifically used for treating the dog thyroid function hyperthyroidism, the dog food has the advantage of specific treatment effect, super quality and competitive price, high safety, high suitability, no drug residue, shorter treatment course, better curative effect, no tolerance, low cost and the like.
Description
Technical field
The present invention relates to dog grain, particularly a kind of dog grain and preparation method thereof.
Background technology
Dog hyperthyroidism is because thyroid hormone secretion is too much, the endocrine system disease that basic metabolism is hyperfunction.
Dog hyperthyroidism is mainly in 4 ~ 18 years old, and boxing coach dog, complete lattice dog and Jin Mao seek hunting dog and easily send out.
The cause of disease: dog hyperthyroidism is caused by thyroid tumors.Thyroid tumors are positioned at the pharynx of neck veutro to chest place.1/3 of dog primary thyroid tumour is adenoma, and 2/3 is gland cancer, and multidigit is Unilateral.60% of 15% and gland cancer of primary thyroid adenoma presents clinical symptoms, only could finding when corpse is analysed of other.It is very thin that thyroid adenoma general diameter is less than 2cm, transparent capsule sample.Individual other is comparatively large, has thick fibrous capsule, is full of yellowish-brown liquid in capsule.Thyroid adenocarcinoma often transfers to lungs and pharynx back of the body lymph node.Boxing coach dog the most easily suffers from thyroid adenoma.
Clinical symptom: hyperthyroidism initial stage, occur drinking diuresis, polydipsia, appetite strengthens, and loses weight subsequently, becomes thin more.Defecation frequency increases, and body is weary unable, heartbeat and the high Sheng of arteries and veins, and ecg voltage raises.Cryophilic place, haves the fidgets, and breathes and easy fatigue.There is excitement later, uneasy.Motion is active.Exophthalmos ', palpebral edema, sheds tears, conjunctival congestion.From palpation pharynx carries out neck to chest along tracheae both sides, the thyroid tumors (normally touch less than) of enlargement can be touched.Thyroid tumors can cause dysphagia, dyspneic symptom.Many symmetrically property that diffuse goiter is large, nodular enlargement shows as asymmetrical type more.
Laboratory inspection: in blood plasma, thyroxine and T4 concentration raise.Within 1 ~ 2 month, promptly grow after tumour enlargement finds.Substantially thyroid adenocarcinoma can be diagnosed as.
At present, treat dog hyperthyroidism to have: radioiodine therapy, thyroid gland do not excise entirely, ATD therapy.
ATD therapy is based on Thiourea, and conventional thiouracil and rosickyite pyrimidine, rosickyite pyrimidine, 10mg/kg body weight, takes orally, every day 1 time.After sb.'s illness took a favorable turn, reduce dosage.Sulphur preparation can be used as the alternative medicine of Thiourea.Dog can every day oral saturated KI liquid 5, continuous 1 ~ 2 week.Therapeutic scheme, medicine are all limited, do not reach desirable result for the treatment of, and treatment cost are higher.But the traditional Chinese medicine prevention dog hyperthyroidism initial stage not only has the therapeutic action of western modern medicine, also there is the effect of nourishing Yin and falling fire, removing pattogenic heat from the blood and toxic material from the body, Bu Qi Fu Zheng, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill dog, selected natural Chinese traditional medicines material, make drug effect directly arrive focus, the course for the treatment of is shorter, and curative effect is better, prolonged application has no drug resistance, drug residue free, cost price is cheap, can effective symptom management.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of dog grain containing being used for the treatment of the hyperthyroid Chinese medicine additive of dog, adopt the dog grain containing this Chinese medicine additive can overcome the various defects of Chinese medicine of the prior art and Western medicine, there is the effect of nourishing Yin and falling fire, removing pattogenic heat from the blood and toxic material from the body, Bu Qi Fu Zheng, treatment dog hyperthyroidism has merit, and specially to imitate grand, of high quality and at a reasonable price, safe and applicable, drug residue free, the course for the treatment of shorter, curative effect is better, have no drug resistance, drug residue free, the advantageous feature such as cost price is cheap.
In order to realize foregoing invention object, the invention provides one and be used for the treatment of the hyperthyroid dog grain of dog, be used for the treatment of the hyperthyroid dog grain of dog, it is characterized in that, described dog grain comprises following raw material: wheat, black sesame powder, lotus root starch, mussel, taro meal, pumpkin powder, orange, banana, duck, black fungus, tomato, grape, mulberries, dried longan pulp, black soya bean, vitamin premix and microelement pre-mix material.
In described dog grain, the parts by weight of each raw material are: wheat 20-40 weight portion, black sesame powder 30-60 weight portion, lotus root starch 22-30 weight portion, mussel 13-20 weight portion, taro meal 10-15 weight portion, pumpkin powder 10-20 weight portion, orange 14-25 weight portion, banana 17-30 weight portion, duck 10-15 weight portion, black fungus 20-30 weight portion, tomato 15-20 weight portion, grape 10-30 weight portion, mulberries 3-7 weight portion, dried longan pulp 5-13 weight portion, black soya bean 10-20 weight portion, vitamin premix 0.1-0.5 weight portion and microelement pre-mix material 0.1-0.5 weight portion.
Described dog grain also comprises Chinese medicine additive, in described dog grain, the parts by weight of each raw material are: wheat 20-40 weight portion, black sesame powder 30-60 weight portion, lotus root starch 22-30 weight portion, mussel 13-20 weight portion, taro meal 10-15 weight portion, pumpkin powder 10-20 weight portion, orange 14-25 weight portion, banana 17-30 weight portion, duck 10-15 weight portion, black fungus 20-30 weight portion, tomato 15-20 weight portion, grape 10-30 weight portion, mulberries 3-7 weight portion, dried longan pulp 5-13 weight portion, black soya bean 10-20 weight portion, vitamin premix 0.1-0.5 weight portion, microelement pre-mix material 0.1-0.5 weight portion and Chinese medicine additive 2-5 weight portion.
In described dog grain, the parts by weight of each raw material are: wheat 25 weight portion, black sesame powder 45 weight portion, lotus root starch 26 weight portion, mussel 16 weight portion, taro meal 13 weight portion, pumpkin powder 16 weight portion, orange 21 weight portion, banana 23 weight portion, duck 12 weight portion, black fungus 24 weight portion, tomato 17 weight portion, grape 18 weight portion, mulberries 5 weight portion, dried longan pulp 11 weight portion, black soya bean 16 weight portion, vitamin premix 0.5 weight portion, microelement pre-mix material 0.3 weight portion and Chinese medicine additive 4 weight portion.
Described trace mineral supplement comprises one or more mixing in iron, manganese, zinc, copper; Described vitamin premix is vitamin A, vitamin D, vitamin E, vitamin K, pantothenic acid, Cobastab
12in one or more mixing.
Described Chinese medicine additive comprises following raw medicinal material: radix rehmanniae recen, mulberry fruit, the fruit of Chinese magnoliavine, moutan bark, cornu bubali, turtle shell, chorion ovi, mother-of-pearl, cape jasmine, gypsum, the wind-weed, radix polygonati officinalis, the stem of noble dendrobium, the Radix Astragali, radix bupleuri, capsule lotus and Botrychium lanuginosum Wall.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: radix rehmanniae recen 25-35 weight portion, mulberry fruit 15-25 weight portion, fruit of Chinese magnoliavine 12-20 weight portion, moutan bark 10-15 weight portion, cornu bubali 10-17 weight portion, turtle shell 10-15 weight portion, chorion ovi 10-18 weight portion, mother-of-pearl 25-35 weight portion, cape jasmine 12-20 weight portion, gypsum 12-19 weight portion, wind-weed 12-18 weight portion, radix polygonati officinalis 28-35 weight portion, stem of noble dendrobium 20-29 weight portion, Radix Astragali 15-25 weight portion, radix bupleuri 12-22 weight portion, capsule lotus 8-15 weight portion and Botrychium lanuginosum Wall 12-19 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: radix rehmanniae recen 32 weight portion, mulberry fruit 21 weight portion, the fruit of Chinese magnoliavine 17 weight portion, moutan bark 12 weight portion, cornu bubali 15 weight portion, turtle shell 14 weight portion, chorion ovi 13 weight portion, mother-of-pearl 31 weight portion, cape jasmine 16 weight portion, gypsum 14 weight portion, the wind-weed 16 weight portion, radix polygonati officinalis 29 weight portion, the stem of noble dendrobium 24 weight portion, the Radix Astragali 22 weight portion, radix bupleuri 20 weight portion, capsule lotus 11 weight portion and Botrychium lanuginosum Wall 15 weight portion.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, adds hot reflux 1 ~ 3 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 85 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders, obtain Chinese medicine additive powder.
The present invention also provides a kind of preparation method being used for the treatment of the hyperthyroid dog grain of dog, and described preparation method comprises the following steps:
(1) destruction step: take wheat, mussel, orange, banana, duck, black fungus, tomato, grape, mulberries, dried longan pulp and black soya bean by ratio of weight and the number of copies and be mixed even, drop into pulverizer and carry out Crushing of Ultrafine, 1.0mm sieve is crossed after pulverizing, then the mixture after sieving is steamed 1-2 hour at 100 DEG C, obtain mixture 1;
(2) batching step: take black sesame powder, lotus root starch, taro meal, pumpkin powder, vitamin premix, microelement pre-mix material and Chinese medicine additive according to ratio of weight and number, mix with the mixture 1 obtained in destruction step (1), drop into mixer, mix, incorporation time is 30-60s;
(3) mixture obtained by batching step (2), at 80 DEG C of heating 10-15 minute, then extrudes oven dry and obtains dog grain.
The invention has the beneficial effects as follows: dog grain of the present invention contain have nourishing Yin and falling fire, removing pattogenic heat from the blood and toxic material from the body, the Chinese medicine additive of Bu Qi Fu Zheng effect, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill dog, there is the course for the treatment of shorter, curative effect is better, prolonged application has no drug resistance, drug residue free, the advantages such as cost price is cheap, Chinese medicine additive and other dog grain raw materials cooperatively interact, interact, treatment dog hyperthyroidism has merit and specially imitates grand, super quality and competitive price, safe and applicable, the advantageous feature such as drug residue free, marketing can be carried out, be of great practical significance.
Detailed description of the invention
Chinese veterinarian thinks, because the seven human emotions are unsuccessful, and stagnation of liver qi, qi depression transforming into fire, above attacks in head, therefore dog being irritable and getting angry easily is suffered from hyperthyroidism; Liver depression forming fire, stomach-Yin of burning, exuberance of stomach fire, therefore rapid digestion of food and polyorexia; Deficiency-weakness of spleen-QI, failure of the spleen to transport and transform, then become thin weak; The deficiency of the kidney yin, water files to nourish wood, then liver-yang hyperactivity, trembles; Heart kidney-yin deficiency, then hidrosis; Yin asthenia generating intrinsic heat, then To Be Protected from Heat.Suffer from the dog ferritic deficiency of Yin, meet the obstruction of the circulation of vital energy, then easily change fire, cloudy blood of burning.In a word, suffer from dog qi depression transforming into fire, refining liquid is phlegm, and mental disorder is handed over and hindered in throat, then send out and swell in goitre; Mental disorder is condensed in order, then exophthalmos '.
Chinese medicine additive of the present invention follows the principle of nourishing Yin and falling fire, removing pattogenic heat from the blood and toxic material from the body, Bu Qi Fu Zheng, provide one and be used for the treatment of the hyperthyroid dog grain of dog, it comprises Chinese medicine additive, and Chinese medicine additive comprises following raw medicinal material: radix rehmanniae recen, mulberry fruit, the fruit of Chinese magnoliavine, moutan bark, cornu bubali, turtle shell, chorion ovi, mother-of-pearl, cape jasmine, gypsum, the wind-weed, radix polygonati officinalis, the stem of noble dendrobium, the Radix Astragali, radix bupleuri, capsule lotus and Botrychium lanuginosum Wall.Hyperthyroidism is hypermetabolism disease, consume body qi-blood-body fluid amount many, therefore with radix rehmanniae recen, mulberry fruit, fruit of Chinese magnoliavine nourishing kidney-yin, chorion ovi lung-yin nourishing, the stem of noble dendrobium, radix polygonati officinalis grows stomach-Yin, and all have yin-nourishing righting, rich body is allayed one's hunger the use of promoting the production of body fluid, mother-of-pearl nourishing liver is cloudy, its drug combination such as yin-nourishing and the Radix Astragali has the energy rising Jin Bujin, moutan bark, cornu bubali, turtle shell has cool liver to fall the merit of liver, the non-enlargement person of thyroid gland has the power of falling fiery astringe yin, righting is not got rid of evils such as is closed door and stays bandit, therefore with cape jasmine, gypsum, the wind-weed, radix bupleuri is with on clear, in, the heat of lower three Jiao, capsule lotus and the nourishing liver and kidney all medicines of Botrychium lanuginosum Wall share, nourishing Yin and clearing heat purging intense heat, nourishing Yin and promoting production of body fluid, softening and resolving hard mass, the rich body of correction, be hyperthyroidism answer disease good recipe.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Radix rehmanniae recen: sweet, cold; The thoughts of returning home, liver, kidney channel.Shennong's Herbal: " taste is sweet, cold.Cure mainly folding to fall, exhausted muscle, in wound, by blood-arthralgia, fill out marrow, longue meat.Make soup except fever and chills and gather, except numbness.Survivor is especially good." heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, pain relieving, menstruation regulating, cool blood, hemostasis invigorate blood circulation.Radix rehmanniae recen is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promotes the production of body fluid to quench thirst, and is usually used in the diseases such as treatment hectic fever due to yin consumptive disease heat, throat pain, blood-stained sputum.
Mulberry fruit: sweet; Acid; Cold in nature.Return liver; Kidney channel.Nourishing yin and nourishing blood; Promote the production of body fluid; Ease constipation.What main kidney deficiency and liver and deficiency of blood essence were lost has a dizzy spell; Soreness of waist tinnitus; Poliosis; Insomnia and dreamful sleep; Tianjin wound is thirsty; Quench one's thirst; The dry constipation of intestines
The fruit of Chinese magnoliavine: sour, sweet, temperature.Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming.Breathe heavily for void of coughing for a long time, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and feeble pulse of losing heart, interior heat is quenched one's thirst, palpitation and insomnia.
Moutan bark: cold nature, bitter is pungent, nontoxic.Enter the heart, liver, kidney channel.Have and purify the blood, the function of promoting blood circulation to remove blood stasis.Cure mainly macula to spit blood, amenorrhea due to stagnation of blood, premenstrual gesture, carbuncle sore tumefacting virus, traumatic blood stasis, the deficiency of Yin sends out gesture, lossless hectic fever due to yin.
Cornu bubali: bitter salty, cold.Enter the heart, liver, spleen, stomach four warp." Luchuan book on Chinese herbal medicine ": " removing pattogenic heat from the blood and toxic material from the body, only nosebleed.Control pyreticosis stupor, numb acne macula, spit blood, bleeding from five sense organs or subcutaneous tissue, blood-head, dark urine." heat-clearing, cool blood, removing toxic substances.Control pyreticosis headache, high fever coma, macula, tells nosebleed, child convulsion, and the pharynx of larynx numbness is swollen.
Turtle shell: salty, cold, returns liver, kidney channel." property of medicine opinion ": " main place food, disease block, Xuan addiction gas, cold lump in the abdomen, labor are thin, lower gas, and except bone heat, between joint, labor heat, is solidly jammed.Control married woman leak down the five colors win thin person." nourshing kidney checking exuberance of yang, softening and resolving hard mass.Cure mainly hectic fever due to yin labor heat, malaria be female, lower hard, the pain in the back of the side of body, through closing the diseases such as abdominal mass.
Chorion ovi: taste is sweet; Light; Property is put down.Return spleen; Stomach; Lung channel.Nourishiing yin to clear away the lung-heat; Sore; Disappear screen; Synthetism.Asthma is coughed outside main; Pharyngalgia aphonia; Scrofula; Unhealing ulcer; The raw ocular of order; Vertigo; Trauma fracture.
Mother-of-pearl: salty, cold.Return liver, the heart channel of Hang-Shaoyin.Calming the liver, arresting convulsion improving eyesight.Dizzy for having a headache, irritated insomnia, the hot hot eyes of liver, the empty blurred vision of liver.
Cape jasmine: bitter, cold, nontoxic; Enter the heart channel of Hang-Shaoyin, Liver Channel, lung channel, stomach warp, tri-jiao channel.Shennong's Herbal: " perverse trend in main five, pathogenic heat in the stomach gas, flushing wine blister Cha nose, the red impetigo ulcer of white leprosy." " Mingyi Bielu ": " Great Cold, nontoxic.Cure mainly the red pain of order heat, the large heat of chest heart intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas." purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, cooling blood and hemostasis.Pyreticosis is vexed, irascibility hot eyes, and headache, jaundice with damp-heat pathogen, stranguria, bloody flux hematuria, aphthae, sore swollen toxin, sprains and swell and ache.
Gypsum: pungent, sweet, is slightly cold.Attach to the lung and stomach meridians.Cure mainly apoplexy fever and chills, heart subinverse gas is frightened to be breathed heavily, and dry tongue is burnt, can not cease, hardness and fullness in the abdomen pain, evil removing ghost, puerperium metal-inflicted wound.Except time gas headache body heat, three burnt large heat, skin heat, ties gas in stomach, expelling pathogenic factors from muscles by diaphoresis, only quenches one's thirst tired inverse, the sudden and violent gas of abdominal distension, and pharynx heat of panting, also can do bath soup.
The wind-weed: bitter, sweet, cold in nature, enters lung, stomach, kidney channel, has relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, removing heat from the lung to relieve cough, and cure mainly fever caused by exogenous pathogenic factors, high heat is irritated, lung-heat type cough, and interior heat such as to be quenched one's thirst at the symptom; Its bitter cold matter is moistened, and property sedimentation can heat-clearing, can promote the production of body fluid again, kindly controls warm disease and evil and enters gas and divide, and heat is contained and hindered Tianjin; Also diabetes is used for the treatment of; Phlegm-heat obstructing lung and breathing heavily, xeropulmonary cough, phlegm is few unfavorable; Fire excess from yin deficiency, the diseases such as flaring up of deficient fire.
Radix polygonati officinalis: sweet, is slightly cold.Attach to the lung and stomach meridians.Nourishing yin to moisten dryness, promotes the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior heat is quenched one's thirst.
The stem of noble dendrobium: cold nature, taste is sweet, returns stomach, kidney channel, has reinforcing stomach reg fluid, nourishing Yin and clearing heat effect.Cure mainly the moon and hinder body fluid deficiency, dry polydipsia, food is few retches, abnormal heat after being ill, and order is secretly not clear waits card.
The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Essentials of Matea Medica: " Radix Astragali, raw with solid table, losslessly to send out, to have sweat to stop; Process with bowl spares, beneficial vigour, strong taste.Green blood, myogenic, apocenosis Neto, sore carbuncle panacea.Variola does not rise, and the deficiency of yang should it without hot person." " book on Chinese herbal medicine justice ": " temperature supports taste, and all middle gas is depressed for the Radix Astragali, soil in help, and spleen soil is weak, and the clear gas person of sinking is the most suitable.Its skin goes directly the skin table muscle of people, and solid protection defends sun, and enriching table point, is its speciality, so all diseases of exterior deficiency, and the most refreshing agent." function shows arrest sweating, inducing diuresis for removing edema admittedly, the apocenosis of holder sore, regulating fluid apssage.The Radix Astragali makes contractile ability strengthen, and can improve the blood circulation of whole body, can coronary artery dilator, Renal vascular and adder-wort peripheral vessel, make skin blood overactive circulation; The nonspecific immunity power of body can be improved, protect the liver and fall hypoglycemic effect, have inhibitory action to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumopniae, shigella dysenteriae etc.The Radix Astragali can significantly affect SPL Information Conduction, realizes immunoregulation effect.Can be used for high blood pressure, ischemic heart disease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis.
Radix bupleuri: cold nature, bitter, pungent, return Liver Channel, gallbladder channel.Strongly fragrant, the loose effect of fire of tool soothing liver-gallbladder, thin gas solution.Function: table expels the heat-evil thoroughly, soothing liver-qi stagnation, elevate a turnable ladder yang-energy.Cure mainly: the heating that cures cold, fever and chills deficient fever.Children's's acne rash waste heat, lean and haggard belly expands, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, and uterus comes off, irregular menstruation.
Capsule lotus: sweet, micro-hardship is cool.Strengthening by means of tonics, wines used as antirheumatic, stimulate the menstrual flow network.For strengthening the spleen and stomach, filling liver kidney.
Botrychium lanuginosum Wall: micro-hardship is flat, poisonous.Clearing heat and detoxicating, nourishing, flat liver dissipating bind.Control postpartum weakness, liver is suffered from a deficiency of the kidney weak, sore, wind poison, the enlargement of lymph node, raw screen in order.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine additive
Get radix rehmanniae recen 32 weight portion, mulberry fruit 21 weight portion, the fruit of Chinese magnoliavine 17 weight portion, moutan bark 12 weight portion, cornu bubali 15 weight portion, turtle shell 14 weight portion, chorion ovi 13 weight portion, mother-of-pearl 31 weight portion, cape jasmine 16 weight portion, gypsum 14 weight portion, the wind-weed 16 weight portion, radix polygonati officinalis 29 weight portion, the stem of noble dendrobium 24 weight portion, the Radix Astragali 22 weight portion, radix bupleuri 20 weight portion, capsule lotus 11 weight portion and Botrychium lanuginosum Wall 15 weight portion.
Preparation method comprises the following steps:
The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 times is the ethanol of 95%, adds hot reflux 3 hours, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 times to be again the ethanol of 95%, to add hot reflux 1 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 hour, pulverize, sieve, obtain 300 object micropowders, obtain Chinese medicine additive powder.
Embodiment 2 dog grain
Embodiments provide one and be used for the treatment of the hyperthyroid dog grain of dog, in dog grain, the parts by weight of each raw material are: wheat 25 weight portion, black sesame powder 45 weight portion, lotus root starch 26 weight portion, mussel 16 weight portion, taro meal 13 weight portion, pumpkin powder 16 weight portion, orange 21 weight portion, banana 23 weight portion, duck 12 weight portion, black fungus 24 weight portion, tomato 17 weight portion, grape 18 weight portion, mulberries 5 weight portion, dried longan pulp 11 weight portion, black soya bean 16 weight portion, vitamin premix 0.5 weight portion, microelement pre-mix material 0.3 weight portion and Chinese medicine additive 4 weight portion, wherein Chinese medicine additive is the Chinese medicine additive powder of embodiment 1, described trace mineral supplement is iron, manganese, zinc, copper, described vitamin premix is vitamin A, vitamin D, vitamin E, vitamin K, pantothenic acid, Cobastab
12.
Its preparation method comprises the following steps:
(1) destruction step: take wheat, mussel, orange, banana, duck, black fungus, tomato, grape, mulberries, dried longan pulp and black soya bean by ratio of weight and the number of copies and be mixed even, drop into pulverizer and carry out Crushing of Ultrafine, 1.0mm sieve is crossed after pulverizing, then the mixture after sieving is steamed 1 hour at 100 DEG C, obtain mixture 1;
(2) batching step: take black sesame powder, lotus root starch, taro meal, pumpkin powder, vitamin premix, microelement pre-mix material and Chinese medicine additive according to ratio of weight and number, mix with the mixture 1 obtained in destruction step (1), drop into mixer, mix, incorporation time is 30s;
(3) mixture obtained by batching step (2), 80 DEG C of heating 15 minutes, then extrudes oven dry and obtains dog grain.
The toxicity test of Chinese medicine additive:
1, trial drug
Choose radix rehmanniae recen 32g, mulberry fruit 21g, fruit of Chinese magnoliavine 17g, moutan bark 12g, cornu bubali 15g, turtle shell 14g, chorion ovi 13g, mother-of-pearl 31g, cape jasmine 16g, gypsum 14g, wind-weed 16g, radix polygonati officinalis 29g, stem of noble dendrobium 24g, Radix Astragali 22g, radix bupleuri 20g, capsule lotus 11g and Botrychium lanuginosum Wall 15g to mix, be ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filter residue; Again add in 1400g cold water by filtering the filter residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtered fluid, obtaining the second filtrate; Merge twice filtrate, reduced pressure concentration remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the changes of weight of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and control group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range (NR), without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
Contrast test
Xi'an City, Shanxi Province pet outpatient service, in December ,-2013 in February, 2010, accepts 170 pet dogs nearly altogether for medical treatment and is diagnosed as dog hyperthyroidism, is all that complete lattice dog and Jin Mao seek hunting dog.Pet dog owner describes these pet dogs appearance many drinks diuresis in various degree, polydipsia, and appetite strengthens, and loses weight subsequently, becomes thin, and defecation frequency increases, and the weary unable phenomenon of body, with uneasiness, exophthalmos ', palpebral edema, sheds tears, conjunctival congestion.From pharynx carry out neck to chest along tracheae both sides palpation, the thyroid tumors of enlargement can be touched.
The ill dog 80 of making a definite diagnosis is divided into two groups at random, is respectively embodiment group and control group, the ill dog of two groups all without significant difference, has comparativity in body weight, the state of an illness etc.Embodiment group and control group use the dog grain of the embodiment of the present invention 2 and traditional dog grain to feed ill dog respectively, and wherein, control group also needs to carry out conventional therapy, takes rosickyite pyrimidine, 10mg/kg body weight, for oral administration, every day 1 time.Experimental period is 90 days, and result as shown in Table 1 and Table 2.Wherein, cure: symptom is obviously improved, body weight increases, decreased heart rate, and thyroxine (<40 micrograms per litre) and triiodo thryonine in the visible blood plasma of laboratory examination (<2000 receive grams per liter) concentration is normal; Invalid: clinical symptoms are not improved and even increased the weight of, thyroxine (>40 micrograms per litre) and triiodo thryonine in the visible blood plasma of laboratory examination (>2000 receive grams per liter) concentration still exceeds normal range (NR).
The table 1 liang experimental group dog average weight table of comparisons
Data from table 1: compared with control group, use the ill dog of drug therapy of the present invention, the dog that its average weight is treated than traditional therapy exceeds 1.9kg respectively, and average daily gain exceeds 30.0g/d respectively.
The result for the treatment of table of comparisons of table 2 liang experimental group dog
Data from table 2: compared with conventional medicament, the dog grain of the embodiment of the present invention 2 has advantage that is evident in efficacy, cheap, that have no side effect in treatment dog hyperthyroidism.
Known by contrast test: compared with conventional medicament, the dog grain of the embodiment of the present invention 2 has toxic and side effect advantage little, evident in efficacy in treatment dog hyperthyroidism.
Known by contrast test: ill dog average weight, the cure rate of the dog grain nursing of the embodiment of the present invention 2 are all better than control group, namely dog grain of the present invention can not only treat dog hyperthyroidism, the nutritional need of ill dog can also be met, be specially adapted to suffer from hyperthyroid dog nutritional need.
The golden hair in Xi'an, Shaanxi in March, 2012 seeks hunting dog, occurred before half a year drinking diuresis more, polydipsia, appetite strengthens, the symptom such as lose weight, become thin subsequently, from palpation pharynx carries out neck to chest along tracheae both sides, can touch the thyroid tumors of enlargement, in the visible blood plasma of laboratory examination, thyroxine 48 micrograms per litre and triiodo thryonine 2130 receive grams per liter, are diagnosed as dog hyperthyroidism.The dog grain of the embodiment of the present invention of feeding 2, feed 50 days, ill dog symptom is obviously improved, the 80th day, and check that thyroxine 34 micrograms per litre and triiodo thryonine 1900 receive grams per liter, recovery from illness, follows up a case by regular visits to and do not recur for 1 year half.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a dog grain, it is characterized in that, described dog grain comprises following raw material: wheat, black sesame powder, lotus root starch, mussel, taro meal, pumpkin powder, orange, banana, duck, black fungus, tomato, grape, mulberries, dried longan pulp, black soya bean, vitamin premix and microelement pre-mix material.
2. dog grain according to claim 1, it is characterized in that, in described dog grain, the parts by weight of each raw material are: wheat 20-40 weight portion, black sesame powder 30-60 weight portion, lotus root starch 22-30 weight portion, mussel 13-20 weight portion, taro meal 10-15 weight portion, pumpkin powder 10-20 weight portion, orange 14-25 weight portion, banana 17-30 weight portion, duck 10-15 weight portion, black fungus 20-30 weight portion, tomato 15-20 weight portion, grape 10-30 weight portion, mulberries 3-7 weight portion, dried longan pulp 5-13 weight portion, black soya bean 10-20 weight portion, vitamin premix 0.1-0.5 weight portion and microelement pre-mix material 0.1-0.5 weight portion.
3. dog grain according to claim 1 and 2, it is characterized in that, described dog grain also comprises Chinese medicine additive, in described dog grain, the parts by weight of each raw material are: wheat 20-40 weight portion, black sesame powder 30-60 weight portion, lotus root starch 22-30 weight portion, mussel 13-20 weight portion, taro meal 10-15 weight portion, pumpkin powder 10-20 weight portion, orange 14-25 weight portion, banana 17-30 weight portion, duck 10-15 weight portion, black fungus 20-30 weight portion, tomato 15-20 weight portion, grape 10-30 weight portion, mulberries 3-7 weight portion, dried longan pulp 5-13 weight portion, black soya bean 10-20 weight portion, vitamin premix 0.1-0.5 weight portion, microelement pre-mix material 0.1-0.5 weight portion and Chinese medicine additive 2-5 weight portion.
4. the dog grain according to any one of claim 1-3, it is characterized in that, in described dog grain, the parts by weight of each raw material are: wheat 25 weight portion, black sesame powder 45 weight portion, lotus root starch 26 weight portion, mussel 16 weight portion, taro meal 13 weight portion, pumpkin powder 16 weight portion, orange 21 weight portion, banana 23 weight portion, duck 12 weight portion, black fungus 24 weight portion, tomato 17 weight portion, grape 18 weight portion, mulberries 5 weight portion, dried longan pulp 11 weight portion, black soya bean 16 weight portion, vitamin premix 0.5 weight portion, microelement pre-mix material 0.3 weight portion and Chinese medicine additive 4 weight portion.
5. dog grain according to claim 1, is characterized in that, described trace mineral supplement comprises one or more mixing in iron, manganese, zinc, copper; Described vitamin premix is vitamin A, vitamin D, vitamin E, vitamin K, pantothenic acid, Cobastab
12in one or more mixing.
6. the dog grain according to any one of claim 1-5, it is characterized in that, described Chinese medicine additive comprises following raw medicinal material: radix rehmanniae recen, mulberry fruit, the fruit of Chinese magnoliavine, moutan bark, cornu bubali, turtle shell, chorion ovi, mother-of-pearl, cape jasmine, gypsum, the wind-weed, radix polygonati officinalis, the stem of noble dendrobium, the Radix Astragali, radix bupleuri, capsule lotus and Botrychium lanuginosum Wall.
7. the dog grain according to any one of claim 1-6, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: radix rehmanniae recen 25-35 weight portion, mulberry fruit 15-25 weight portion, fruit of Chinese magnoliavine 12-20 weight portion, moutan bark 10-15 weight portion, cornu bubali 10-17 weight portion, turtle shell 10-15 weight portion, chorion ovi 10-18 weight portion, mother-of-pearl 25-35 weight portion, cape jasmine 12-20 weight portion, gypsum 12-19 weight portion, wind-weed 12-18 weight portion, radix polygonati officinalis 28-35 weight portion, stem of noble dendrobium 20-29 weight portion, Radix Astragali 15-25 weight portion, radix bupleuri 12-22 weight portion, capsule lotus 8-15 weight portion and Botrychium lanuginosum Wall 12-19 weight portion.
8. the dog grain according to any one of claim 1-7, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: radix rehmanniae recen 32 weight portion, mulberry fruit 21 weight portion, the fruit of Chinese magnoliavine 17 weight portion, moutan bark 12 weight portion, cornu bubali 15 weight portion, turtle shell 14 weight portion, chorion ovi 13 weight portion, mother-of-pearl 31 weight portion, cape jasmine 16 weight portion, gypsum 14 weight portion, the wind-weed 16 weight portion, radix polygonati officinalis 29 weight portion, the stem of noble dendrobium 24 weight portion, the Radix Astragali 22 weight portion, radix bupleuri 20 weight portion, capsule lotus 11 weight portion and Botrychium lanuginosum Wall 15 weight portion.
9. the dog grain according to any one of claim 1-8, is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, adds hot reflux 1 ~ 3 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 85 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders, obtain Chinese medicine additive powder.
10. the preparation method of the dog grain according to any one of claim 1-8, is characterized in that, described preparation method comprises the following steps:
(1) destruction step: take wheat, mussel, orange, banana, duck, black fungus, tomato, grape, mulberries, dried longan pulp and black soya bean by ratio of weight and the number of copies and be mixed even, drop into pulverizer and carry out Crushing of Ultrafine, 1.0mm sieve is crossed after pulverizing, then the mixture after sieving is steamed 1-2 hour at 100 DEG C, obtain mixture 1;
(2) batching step: take black sesame powder, lotus root starch, taro meal, pumpkin powder, vitamin premix, microelement pre-mix material and Chinese medicine additive according to ratio of weight and number, mix with the mixture 1 obtained in destruction step (1), drop into mixer, mix, incorporation time is 30-60s;
(3) mixture obtained by batching step (2), at 80 DEG C of heating 10-15 minute, then extrudes oven dry and obtains dog grain.
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| CN201510249321.XA CN104799118A (en) | 2015-05-18 | 2015-05-18 | Dog food and preparation method thereof |
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| CN105076816A (en) * | 2015-08-25 | 2015-11-25 | 淄博大公元工贸有限公司 | Snack pumpkin strip for pet dog and production method thereof |
| CN108713654A (en) * | 2018-05-24 | 2018-10-30 | 邢台市伊萨宠物食品有限公司 | A kind of production method of microbial fermentation dryness dog food |
| CN112602830A (en) * | 2020-12-17 | 2021-04-06 | 青岛镜川食品有限公司 | Pet feed capable of enhancing immunity and preparation method thereof |
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| CN105076816A (en) * | 2015-08-25 | 2015-11-25 | 淄博大公元工贸有限公司 | Snack pumpkin strip for pet dog and production method thereof |
| CN105076816B (en) * | 2015-08-25 | 2018-11-16 | 山东大公元宠物食品有限公司 | A kind of pet dog snacks pumpkin item and preparation method thereof |
| CN108713654A (en) * | 2018-05-24 | 2018-10-30 | 邢台市伊萨宠物食品有限公司 | A kind of production method of microbial fermentation dryness dog food |
| CN112602830A (en) * | 2020-12-17 | 2021-04-06 | 青岛镜川食品有限公司 | Pet feed capable of enhancing immunity and preparation method thereof |
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