CN104644474A - Foot-protecting gel with moistening and anti-cracking effects - Google Patents
Foot-protecting gel with moistening and anti-cracking effects Download PDFInfo
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- CN104644474A CN104644474A CN201510065227.9A CN201510065227A CN104644474A CN 104644474 A CN104644474 A CN 104644474A CN 201510065227 A CN201510065227 A CN 201510065227A CN 104644474 A CN104644474 A CN 104644474A
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Abstract
The invention relates to a foot-protecting gel with moistening and anti-cracking effects. The foot-protecting gel is composed of the following components: a badger fat preparation, a gelatinizing agent, a humectant and a preservative. The compatibility of the badger fat and the water is increased through a nano-badger fat preparation so that the problem of system turbidity caused by adding of the badger fat into the water gel can be overcome. The problem of greasy badger fat foot-protecting product can be fundamentally solved. The foot-protecting gel is simple in process, clear in appearance and fresh in skin feel, and the greasy feeling of the routine heel cream/paste can be avoided; and the foot-protecting gel has good moistening and anti-cracking effect. The badger fat is prepared into a nano preparation by using a nano-package technology so that the fishy smell of the badger fat can be effectively reduced, the compatibility of the badger fat and the water can be increased and the greasy problem of the badger fat foot-protecting product can be solved.
Description
Technical field
What the present invention relates to a kind of moisture retention crack prevention protects sufficient gel, belongs to cosmetic technical field.
Background technology
Ancient Times in China is for the method for the treatment of podoschisis, foot is done, pain in foot has uniqueness.Wherein the most magical with Adeps melis effect, Adeps melis is the fatty oil of mustelid badger.Ju " China's book on Chinese herbal medicine " is recorded; Adeps melis has the special effect of invigorating the spleen and replenishing QI, skin moistening granulation promoting, removing toxic substances and promoting subsidence of swelling, all has good effect for chapped skin, chilblain, burn and scald, limb aching pain and nameless gall, and general symptom can be fully recovered with about 10 days.Because Adeps melis has extremely strong osmosis, after using, can promote that body inner blood circulates, strengthen the metabolism between each tissue, significantly improve foot microcirculation, ensure the supply of foot nutrient, foot's keratodermatitis can be made thinning, no longer dry and cracked, heel muscle recovery elasticity, and no longer recur after treatment.So take Adeps melis as the heel cream/frost of effective ingredient, all the time by the first-selection as treatment podoschisis.
Skin care item at present on the market containing Adeps melis are generally cream or unguentum, utilize the materials such as thickening agent to be directly dispersed in adjuvant by Adeps melis.But because Adeps melis hydrophilic is poor, use rear skinfeel extremely greasy, after particularly smearing foot, due to naked state cannot be kept for a long time, be easy to be wiped by socks, clothes etc., make troubles to cleaning; And because foot is neural flourishing, during the foot that thoroughly cleaning is greasy, user is extremely uncomfortable.
Aqueogel because of outward appearance merrily and lightheartedly thorough, to a kind of refrigerant sense of skin, avoid the greasy feeling of cream, unguentum.But when Adeps melis directly being added hydrogel, whole system easily becomes muddy, cannot embody the due transparent clear characteristic of gel, therefore, be necessary to develop a kind of gel preparation containing Adeps melis, solved the existing defect of protecting sufficient product and existing.
Summary of the invention
What the present invention first object was to provide a kind of moisture retention crack prevention protects sufficient gel, and it is limpid that it has outward appearance, and skinfeel is salubrious, fundamentally can avoid the greasy feeling of conventional heel frost/cream.
To achieve these goals, the present invention adopts following technical scheme:
Moisture retention crack prevention protect a sufficient gel, obtained by the component of following weight portion: 2 ~ 10 parts, nanometer Adeps melis preparation, gelatinizing agent 0.5 ~ 2 part, wetting agent 5 ~ 15 parts, 70 ~ 85 parts, water, pH adjusting agent are appropriate, antiseptic 0 ~ 0.05 part.
The present invention is intended to by nanometer Adeps melis preparation, improves the compatibility of Adeps melis and water, thus overcomes Adeps melis and add hydrogel, and system becomes a muddy difficult problem, and fundamentally solution Adeps melis protects the greasy problem of sufficient product thus.
In the present invention, described gelatinizing agent be selected from carbomer series of products, hypromellose, methylcellulose one or more; Preferred carbomer series of products; Preferred carbomer 934 further.
Described wetting agent is selected from propylene glycol and/or glycerol, is preferably glycerol.
Described pH adjusting agent be selected from sodium hydroxide, sodium dihydrogen phosphate, monoethanolamine, triethanolamine one or more, preferred triethanolamine.
Described antiseptic be selected from methyl hydroxybenzoate, thimerosal, chlorocresol, chlorobutanol or benzoic acid and sodium benzoate one or more; Preferred methyl hydroxybenzoate.Select suitable antiseptic both can extend the shelf-life of product, the characteristic of other component of Absorbable organic halogens again, plays respective effect to greatest extent.
Moisture retention crack prevention of the present invention protect in sufficient gel, described nanometer Adeps melis preparation is adopted and is obtained with the following method:
1) by weight percentage, by 5 ~ 8 parts of soybean phospholipids, 55 ~ 65 parts of glycerol and the mixing of 15 ~ 20 parts of water, under 10000 ~ 12000rpm condition in high speed shear to system without the visible solid content of naked eyes, obtain mixture;
2) by weight percentage, by 5 ~ 6.5 parts of Adeps meliss, 0 ~ 0.5 part of sorbester p17,2.5 ~ 5 parts of polyglycerol monooleate, 2.5 ~ 5 parts of Tween 80s, 1.5 ~ 5 parts of polyoxyethylene castor oils, 0 ~ 0.5 part of caprylic/capric polyethyleneglycol glyceride adds in said mixture, high speed shear 10min under 8000 ~ 10000rpm condition, obtains colostrum;
3) by step 2) gained colostrum under 1000 ~ 2000bar condition high pressure homogenize circulation 5 ~ 10 times, obtain nanometer Adeps melis preparation.
The present invention utilizes the package action of phospholipid microcapsule to reduce Adeps melis fishy smell, and improves Adeps melis property compatible with water by nanotechnology, improves Adeps melis and protects the greasy problem of sufficient product.
The present invention is by the concrete selection to gelatinizing agent, wetting agent, pH adjusting agent component, and screening best of breed method and nanometer Adeps melis preparation compatibility, play each component synergism, and improve the dispersibility of Adeps melis in system, gained gel is limpid transparent, and quality is salubrious.
As the preferred embodiment of the present invention, the sufficient gel that protects of described moisture retention crack prevention is obtained by the component of following weight portion: 8 ~ 10 parts, nanometer Adeps melis preparation, carbomer 934 0.8 ~ 1.5 part, glycerol 5 ~ 15 parts, 73 ~ 85 parts, water, triethanolamine 1 ~ 2 part, methyl hydroxybenzoate 0.05 part.
As the present invention further preferred embodiment, the sufficient gel that protects of described moisture retention crack prevention is obtained by the component of following weight portion: 8 parts, nanometer Adeps melis preparation, carbomer 934 1.5 parts, glycerol 15 parts, 73.45 parts, water, triethanolamine 2 parts, methyl hydroxybenzoate 0.05 part;
Wherein, described nanometer Adeps melis preparation is adopted and is obtained with the following method:
1) by soybean phospholipid, G & W mix, under 12000rpm condition in high speed shear to system without the visible solid content of naked eyes, obtain mixture;
2) by Adeps melis, polyglycerol monooleate, Tween 80, polyoxyethylene castor oil adds in said mixture, and high speed shear 10min under 10000rpm condition, obtains colostrum;
3) by step 2) gained colostrum high pressure homogenize under 2000bar condition circulates 5 times, obtains nanometer Adeps melis preparation.
The present invention second object is to provide a kind of preparation method of protecting sufficient gel of moisture retention crack prevention, comprises the steps:
1) gelatinizing agent is immersed 2 ~ 2.5h in wetting agent, then add suitable quantity of water, left at room temperature over night, obtain mixture;
2) add in said mixture by nanometer Adeps melis preparation, the water of surplus, antiseptic, under 290-310rpm stirring condition, drip pH adjusting agent, what obtain transparence moisture retention crack prevention protects sufficient gel.
Wherein, step 2) in, pH adjusting agent addition is as the criterion to protecting sufficient product pH value codes and standards to make system pH meet skin care item industry.
Adopt technical scheme of the present invention, gained protects sufficient gel and has good moisture retention crack prevention effect, utilize the package action combining nano technology of phospholipid microcapsule simultaneously, Adeps melis is made nanometer formulation, effective reduction Adeps melis fishy smell, improve Adeps melis property compatible with water, solve Adeps melis and protect the greasy problem of sufficient product.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting scope of the present invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercial acquisition.
Embodiment 1 one kinds of moisture retention crack preventions protect sufficient gel
Formula is as follows:
| Content | Weight (g) |
| Nanometer Adeps melis preparation | 10 |
| Carbomer 934 | 0.8 |
| Glycerol | 5 |
| Triethanolamine | 1 |
| Water | 83.15 |
| Methyl hydroxybenzoate | 0.05 |
Wherein, described nanometer Adeps melis pharmaceutical formulation is as follows:
The preparation method of this nanometer Adeps melis preparation is as follows:
1) by above-mentioned recipe quantity, soybean phospholipid, G & W is taken, high speed shear under 10000rpm condition, without the visible solid content of naked eyes to system;
2) Adeps melis, sorbester p17, polyglycerol monooleate, Tween 80, polyoxyethylene castor oil, caprylic/capric polyethyleneglycol glyceride are added step 1) product, continues high speed shear 10min under 8000rpm condition, obtains colostrum;
3) by step 2) gained colostrum, high pressure homogenize cycle-index 7 times under middle 1000bar condition, obtains transparent clear shape nanometer Adeps melis preparation.
Embodiment 2 one kinds of moisture retention crack preventions protect sufficient gel (most preferred embodiment)
Formula is as follows:
| Content | Weight (g) |
| Nanometer Adeps melis preparation | 8 |
| Carbomer 934 | 1.5 |
| Glycerol | 15 |
| Triethanolamine | 2 |
| Water | 73.45 |
| Methyl hydroxybenzoate | 0.05 |
Wherein, described nanometer Adeps melis pharmaceutical formulation is as follows:
| Content | Weight ratio (part) |
| Adeps melis | 5 |
| Soybean phospholipid | 8 |
| Polyglycerol monooleate | 5 |
| Tween 80 | 5 |
| Polyoxyethylene castor oil | 5 |
| Glycerol | 57 |
| Water | 15 |
The preparation method of this nanometer Adeps melis preparation is as follows:
1) by above-mentioned recipe quantity, soybean phospholipid, G & W is taken, high speed shear under 12000rpm condition, without the visible solid content of naked eyes to system;
2) by Adeps melis, polyglycerol monooleate, Tween 80, polyoxyethylene castor oil, step 1 is added) product, continues high speed shear 10min under 10000rpm condition, obtains colostrum;
3) by step 2) gained colostrum, by high pressure homogenizer process under 2000bar condition, circulates 5 times, obtains transparent clear shape nanometer Adeps melis preparation.
Embodiment 3 one kinds of moisture retention crack preventions protect sufficient gel
Formula is identical with embodiment 2, and difference is not containing methyl hydroxybenzoate.
Embodiment 4 one kinds of moisture retention crack preventions protect sufficient gel
Formula is identical with embodiment 2, and difference is carbomer 934 to replace with hypromellose.
Effect test is verified
Experimental example 1 skinfeel is tested
Sample: the sample 1-4 prepared by embodiment of the present invention 1-4.
Reference substance 1: nanometer Adeps melis preparation in embodiment 2 is replaced with common Adeps melis, and other amounts of components are constant.Reference substance 2: by the nanometer Adeps melis preparation described in embodiment 2 soybean phospholipid omit, other components and consumption constant.
1) greasy feeling test method: blind cross matching, in process of the test, 6 healthy premenopausal volunteers, muffle eye, respectively to the sample of numbering in advance, carry out skinfeel experience, tester is applied in heel, by the marking of greasy feeling degree, adopt the five-grade marking system, average.Score value is larger, more greasy, and 0 point represents salubrious, do not have a bit greasy feeling.
2) moisturizing, effect of anti-cracking experimental technique: 12 healthy premenopausal volunteers carry out skinfeel experience, smear 1 time every night, smear 1 week continuously, give a mark, the results are shown in Table 1 by moisturizing and effect of anti-cracking.
Table 1 skinfeel result of the test
As can be seen from the table, the moisture retention crack prevention prepared by the present invention protects sufficient gel at the greasy feeling keeping original basis protecting sufficient product moisture retention crack prevention effect can also significantly being improved in use procedure, achieves unexpected technique effect.
Experimental example 2 particle size determination
Test specimen: the sample 1-4 prepared by embodiment 1-4;
Particle size determination: first sample 1-4 ultra-pure water is diluted 30 times, adopt Particle Size Analyzer to detect particle diameter, result of the test is in table 2.
The different sample particle diameter size of table 2
From table, the mean diameter of product of the present invention is less than 170nm.
Experimental example 3 fishy smell sensory test
Sample: the sample 1-4 prepared by embodiment of the present invention 1-4.
Reference substance 1: nanometer Adeps melis preparation in embodiment 2 is replaced with common Adeps melis, and other amounts of components are constant.
Reference substance 2: by the nanometer Adeps melis preparation described in embodiment 2 soybean phospholipid omit, other components and consumption constant.
Sample and reference substance are divided into brand-new standby and place 12 months at normal temperatures.
Test method:
Blind cross matching, before each news sample, experimenter treats more than 30min in outdoor fresh air.In process of the test, 6 olfactory sensation healthy premenopausal volunteers, respectively to the sample of numbering in advance, hear fishy smell, tapinoma-odour with olfactory sensation, and experience separately with the five-grade marking system record, average.
Table 3 fishy smell sensory test
From table result, utilize phospholipid to wrap up, nanorize process is carried out to Adeps melis, effectively reduce the fishy smell of Adeps melis; Also effectively covered because placing the taste that becomes sour produced for a long time simultaneously.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (9)
1. moisture retention crack prevention protect a sufficient gel, it is characterized in that, obtained by the component of following weight portion: 2 ~ 10 parts, nanometer Adeps melis preparation, gelatinizing agent 0.5 ~ 2 part, wetting agent 5 ~ 15 parts, 70 ~ 85 parts, water, pH adjusting agent are appropriate, antiseptic 0 ~ 0.05 part.
2. according to claim 1 moisture retention crack prevention protect sufficient gel, it is characterized in that, described pH adjusting agent be selected from sodium hydroxide, sodium dihydrogen phosphate, monoethanolamine, triethanolamine one or more.
3. according to claim 1 moisture retention crack prevention protect sufficient gel, it is characterized in that, described antiseptic be selected from methyl hydroxybenzoate, thimerosal, chlorocresol, chlorobutanol or benzoic acid and sodium benzoate one or more.
4. according to claim 1 moisture retention crack prevention protect sufficient gel, it is characterized in that, described gelatinizing agent be selected from carbomer series of products, hypromellose, methylcellulose one or more.
5. according to claim 1 moisture retention crack prevention protect sufficient gel, it is characterized in that, described wetting agent is selected from propylene glycol and/or glycerol, be preferably glycerol.
6. according to claim 1 moisture retention crack prevention protect sufficient gel, it is characterized in that, described nanometer Adeps melis preparation is adopted and is obtained with the following method:
1) by weight percentage, by 5 ~ 8 parts of soybean phospholipids, 55 ~ 65 parts of glycerol and the mixing of 15 ~ 20 parts of water, under 10000 ~ 12000rpm condition in high speed shear to system without the visible solid content of naked eyes, obtain mixture;
2) by weight percentage, by 5 ~ 6.5 parts of Adeps meliss, 0 ~ 0.5 part of sorbester p17,2.5 ~ 5 parts of polyglycerol monooleate, 2.5 ~ 5 parts of Tween 80s, 1.5 ~ 5 parts of polyoxyethylene castor oils, 0 ~ 0.5 part of caprylic/capric polyethyleneglycol glyceride adds in said mixture, high speed shear 10min under 8000 ~ 10000rpm condition, obtains colostrum;
3) by step 2) gained colostrum under 1000 ~ 2000bar condition high pressure homogenize circulation 5 ~ 10 times, obtain nanometer Adeps melis preparation.
7. according to claim 1 moisture retention crack prevention protect sufficient gel, it is characterized in that, obtained by the component of following weight portion: 8 ~ 10 parts, nanometer Adeps melis preparation, carbomer 934 0.8 ~ 1.5 part, glycerol 5 ~ 15 parts, 73 ~ 85 parts, water, triethanolamine 1 ~ 2 part, methyl hydroxybenzoate 0.05 part.
8. according to claim 7 moisture retention crack prevention protect sufficient gel, it is characterized in that, obtained by the component of following weight portion: 8 parts, nanometer Adeps melis preparation, carbomer 934 1.5 parts, glycerol 15 parts, 73.45 parts, water, triethanolamine 2 parts, methyl hydroxybenzoate 0.05 part; Wherein, described nanometer Adeps melis preparation is adopted and is obtained with the following method:
1) by soybean phospholipid, G & W mix, under 12000rpm condition in high speed shear to system without the visible solid content of naked eyes, obtain mixture;
2) by Adeps melis, polyglycerol monooleate, Tween 80, polyoxyethylene castor oil adds in said mixture, and high speed shear 10min under 10000rpm condition, obtains colostrum;
3) by step 2) gained colostrum high pressure homogenize under 2000bar condition circulates 5 times, obtains nanometer Adeps melis preparation.
9. the preparation method of protecting sufficient gel of the arbitrary described moisture retention crack prevention of claim 1-8, is characterized in that, comprise the steps:
1) gelatinizing agent is immersed 2 ~ 2.5h in wetting agent, then add suitable quantity of water, left at room temperature over night, obtain mixture;
2) add in said mixture by nanometer Adeps melis preparation, the water of surplus, antiseptic, under 290-310rpm stirring condition, drip pH adjusting agent, what obtain transparence moisture retention crack prevention protects sufficient gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510065227.9A CN104644474A (en) | 2015-02-06 | 2015-02-06 | Foot-protecting gel with moistening and anti-cracking effects |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510065227.9A CN104644474A (en) | 2015-02-06 | 2015-02-06 | Foot-protecting gel with moistening and anti-cracking effects |
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| CN104644474A true CN104644474A (en) | 2015-05-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510065227.9A Pending CN104644474A (en) | 2015-02-06 | 2015-02-06 | Foot-protecting gel with moistening and anti-cracking effects |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412000A (en) * | 2015-11-23 | 2016-03-23 | 安徽新和成皖南药业有限公司 | Preparation method for mupirocin ointment |
| CN109125189A (en) * | 2018-10-31 | 2019-01-04 | 广东巴松那生物科技有限公司 | A kind of inclusion enclave Essence and preparation method thereof of the instant bright color of energy |
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| CN1723914A (en) * | 2005-07-13 | 2006-01-25 | 凌沛学 | Compound medicine contg. heparin zinc, and its application |
| CN1994275A (en) * | 2006-11-17 | 2007-07-11 | 清华大学 | A nano micro-capsule emulsion of snake oil and method for preparing same |
| CN103251546A (en) * | 2013-06-08 | 2013-08-21 | 刘兆君 | Skin care composition with inflammation diminishing, spot removing and crease resisting functions |
| CN103340776A (en) * | 2013-06-20 | 2013-10-09 | 北华大学 | Magnolia sieboldii compound natural sunscreen cream and preparation method thereof |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256124A (en) * | 1999-11-30 | 2000-06-14 | 韩国英 | Synthetic protein skincare agent |
| CN1723914A (en) * | 2005-07-13 | 2006-01-25 | 凌沛学 | Compound medicine contg. heparin zinc, and its application |
| CN1994275A (en) * | 2006-11-17 | 2007-07-11 | 清华大学 | A nano micro-capsule emulsion of snake oil and method for preparing same |
| CN103251546A (en) * | 2013-06-08 | 2013-08-21 | 刘兆君 | Skin care composition with inflammation diminishing, spot removing and crease resisting functions |
| CN103340776A (en) * | 2013-06-20 | 2013-10-09 | 北华大学 | Magnolia sieboldii compound natural sunscreen cream and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412000A (en) * | 2015-11-23 | 2016-03-23 | 安徽新和成皖南药业有限公司 | Preparation method for mupirocin ointment |
| CN109125189A (en) * | 2018-10-31 | 2019-01-04 | 广东巴松那生物科技有限公司 | A kind of inclusion enclave Essence and preparation method thereof of the instant bright color of energy |
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Application publication date: 20150527 |
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