CN104623136B - A kind of auxiliary antilipemic Chinese herbal medicine health products Radix Angelicae Sinensis Radix Astragali blood-fat-lowering granule and preparation method thereof - Google Patents
A kind of auxiliary antilipemic Chinese herbal medicine health products Radix Angelicae Sinensis Radix Astragali blood-fat-lowering granule and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of auxiliary antilipemic Chinese herbal medicine health products Radix Angelicae Sinensis Radix Astragali blood-fat-lowering granules and preparation method thereof, belong to technical field of traditional Chinese medicine preparation.Blood-fat-lowering granule includes 12~18 parts of 12~18 parts of 8~12 parts of following component Radix Angelicae Sinensis, Radix Astragali, pueraria lobata by weight, 8~12 parts of rhizoma alismatis, 10~15 parts of hawthorn.Preparation method includes the following steps：1st step extracts Radix Angelicae Sinensis, Radix Astragali, pueraria lobata, rhizoma alismatis, hawthorn with water, obtains Aqueous extracts, and Aqueous extracts obtain supernatant after standing；2nd step, by supernatant concentration, obtain thick paste, add after excipient and be uniformly mixed, granulation, it is dry to get.Radix Angelicae Sinensis Radix Astragali blood-fat-lowering granule provided by the invention has preferable assistant lipid-lowering effect, and grain forming degree is good, easy to carry.
Description
Technical field
The present invention relates to a kind of auxiliary antilipemic Chinese herbal medicine health products Radix Angelicae Sinensis Radix Astragali blood-fat-lowering granules and preparation method thereof, in belonging to
Medicine preparation technique field.
Background technology
Hyperlipidemia is an important factor for leading to atherosclerosis and coronary heart disease.Traditional Chinese medicine is adjusting lipid aspects tool
The small unique advantage of toxic side effect, has all carried out numerous studies both at home and abroad, obtains certain achievement.Chinese medicine lipid-loweringing mainly from
4 by way of effect：1, inhibit the absorption of exogenous lipid；2, inhibit endogenous lipid synthesis；3, promote the transhipment of body lipid
And excretion；4, HypercholesterolemicRats are influenced.
But there is need decoction, not portable, the uncertain problem of lipid-lowering effect for conventional Chinese traditional medicines depressing lipid.
Invention content
The purpose of the present invention is：There is provided it is a kind of be convenient for carrying, eat, the auxiliary antilipemic Chinese herbal medicine granule of effect stability.
Technical solution：
According to an aspect of the present invention, a kind of auxiliary antilipemic Chinese herbal medicine health products Radix Angelicae Sinensis Radix Astragali blood-fat-lowering granule includes
Following component by weight：8~12 parts of Radix Angelicae Sinensis, 12~18 parts of Radix Astragali, 12~18 parts of pueraria lobata, 8~12 parts of rhizoma alismatis, hawthorn 10
~15 parts.
The blood-fat-lowering granule further includes having excipient, preferably one or two kinds of mixing in Icing Sugar or dextrin.
According to another aspect of the present invention, the preparation method of the blood-fat-lowering granule, includes the following steps：
1st step extracts Radix Angelicae Sinensis, Radix Astragali, pueraria lobata, rhizoma alismatis, hawthorn with water, Aqueous extracts is obtained, after Aqueous extracts are stood
Obtain supernatant；
2nd step, by supernatant concentration, obtain thick paste, add after excipient and be uniformly mixed, granulation, it is dry to get.
It it is 2 times with the number that water extracts, the 1st amount of water is the 7~9 of medicinal material total weight in 1st step
Times, the 2nd amount of water is 6~8 times of medicinal material total weight, after extraction, merging filtrate.
In 2nd step, one or two kinds of mixing in excipient, preferably Icing Sugar or dextrin；The weight of excipient
Amount is 4 times of thick paste weight.
In 2nd step, vacuum degree -0.03~-0.07MPa in concentration operation, 65~75 DEG C of temperature；What is obtained is thick
Relative density 1.20~1.30 of the cream at 50 DEG C.
In 2nd step, dry temperature is 55~80 DEG C, 5~7 hours drying times.
Advantageous effect
Radix Angelicae Sinensis Radix Astragali blood-fat-lowering granule provided by the invention has preferable assistant lipid-lowering effect, and grain forming degree is good, carries
It is convenient.
Specific implementation mode
Below by specific implementation mode, invention is further described in detail.But those skilled in the art will manage
Solution, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.Specific skill is not specified in embodiment
Art or condition person carry out according to technology or condition described in document in the art or according to product description.Examination used
Production firm person is not specified in agent or instrument, and being can be with conventional products that are commercially available.
The value expressed using range format should be interpreted as not only in a flexible way including clearly enumerating as range
The numerical value of limit value, but also include all single numbers or the subinterval covered in the range, like each numerical value and sub-district
Between be expressly recited out.For example, the concentration range of " about 0.1% to about 5% " should be understood as including not only clearly enumerating
The concentration of about 0.1% to about 5% further includes the single concentration in how（Such as, 1%, 2%, 3% and 4%）The subinterval and（Example
Such as, 0.1% to 0.5%, 1% to 2.2%, 3.3% to 4.4%）.
The pharmacology of Radix Angelicae Sinensis Radix Astragali blood-fat-lowering granule provided by the present invention is as follows：
Radix Angelicae Sinensis：Enrich blood, invigorate blood circulation, the effect of menstruction regulating and pain relieving, moisturize laxation, modern research shows that Radix Angelicae Sinensis have replenishing and activating blood,
The effects that adjusting immunity of organism, anticancer, reducing blood lipid.
Radix Astragali：Invigorating qi for strengthening superficies, pus draining and toxin expelling, diuresis, myogenic.For treatment deficiency of vital energy weak, rush down prolapse of the anus for a long time, spontaneous perspiration, oedema, sub- official
Prolapsus, chronic rephrilis protinuria, reducing blood lipid, diabetes, the long disunion of the open sore part etc..
Hawthorn：Digestion gathered food, scattered blood stasis, expelling tenia.Control meat Ji , Disorder lumps in the abdomen, phlegm and retained fluid, feeling of fullness, acid regurgitation, rush down dysentery, intestines wind, pain in the back,
Hernia postpartum postpartum abdominal pain, lochiorrhagia, pediatric milk food stagnation.Food digesting stomach fortifying, scattered stasis.For meat stagnation, gastric ulcer fullness,
Diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, confidant sting, hernia pain, hyperlipemia.
Pueraria lobata：Rising Yang expelling pathogenic factors from muscles and skin, promoting eruption antidiarrheal, relieving restlessness stop temperature.Cure the wound cold, warm headache Xiang Qiang, and dysphoria with smothery sensation is quenched one's thirst, diarrhea, dysentery
Disease, ecchymosis is impermeable, hypertension, angina pectoris, deafness, reducing blood lipid, blood pressure lowering, norcholesterol, hypoglycemic, weight-reducing etc..
Rhizoma alismatis：Li Shui, excreting dampness expel the heat-evil.Have the effects that reducing blood lipid, blood pressure lowering, diuresis, protection liver.
Modern pharmacological studies have shown that five kinds of Chinese medicine all has effect for reducing blood fat.
Embodiment 1
8 parts of Radix Angelicae Sinensis, 12 parts of Radix Astragali, 12 parts of pueraria lobata, 8 parts of rhizoma alismatis, 10 parts of hawthorn clean according to prescription proportioning, clear water cleans
Afterwards, it sets and adds water in the extractor of multi-functional extraction concentration and recovery unit, refluxing extraction 2 times under normal pressure, the 1st time 7 times of amount water carry
It takes 1 hour, the 2nd time 6 times of amount water extract 1 hour；Merge extracting solution twice, staticly settles 24 hours, take supernatant.By supernatant
It sets in concentration tank (pressure -0.03MPa, 65 DEG C of temperature) and is concentrated into the thick paste that relative density is 1.20 at 50 DEG C；By thick paste with
(weight ratio of three is 1 to excipient (Icing Sugar and dextrin):3:1) it is stirred evenly in desk-top mixer, appropriate 75% second is added
The softwood of " hand is pinched agglomerating, flicking and dissipated " is made in alcohol, then single-size is made with oscillating granulator (20 mesh of sieve)；It is dry,
It is 6 hours dry that manufactured wet granular is set into heated-air circulation oven (75 DEG C of temperature)；After dry particl cooling, particulate matter is obtained.
Embodiment 2
12 parts of Radix Angelicae Sinensis, 18 parts of Radix Astragali, 18 parts of pueraria lobata, 12 parts of rhizoma alismatis, 15 parts of hawthorn, according to prescription proportioning clean, clear water it is clear
After washing, sets and add water in the extractor of multi-functional extraction concentration and recovery unit, refluxing extraction 2 times under normal pressure, the 1st 9 times of amount water
Extraction 1 hour, the 2nd time 8 times of amount water extract 1 hour；Merge extracting solution twice, staticly settles 24 hours, take supernatant.By supernatant
Liquid sets in concentration tank (pressure -0.07MPa, 75 DEG C of temperature) and is concentrated into the thick paste that relative density is 1.30 at 50 DEG C；By thick paste with
(weight ratio of three is 1 to excipient (Icing Sugar and dextrin):3:1) it is stirred evenly in desk-top mixer, appropriate 75% second is added
The softwood of " hand is pinched agglomerating, flicking and dissipated " is made in alcohol, then single-size is made with oscillating granulator (20 mesh of sieve)；It is dry,
It is 6 hours dry that manufactured wet granular is set into heated-air circulation oven (75 DEG C of temperature)；After dry particl cooling, particulate matter is obtained.
Embodiment 3
9 parts of Radix Angelicae Sinensis, 15 parts of Radix Astragali, 15 parts of pueraria lobata, 9 parts of rhizoma alismatis, 12 parts of hawthorn clean according to prescription proportioning, clear water cleans
Afterwards, it sets and adds water in the extractor of multi-functional extraction concentration and recovery unit, refluxing extraction 2 times under normal pressure, the 1st time 8 times of amount water carry
It takes 1 hour, the 2nd time 7 times of amount water extract 1 hour；Merge extracting solution twice, staticly settles 24 hours, take supernatant.By supernatant
It sets in concentration tank (pressure -0.05MPa, temperature 70 C) and is concentrated into the thick paste that relative density is 1.25 at 50 DEG C；By thick paste and tax
(weight ratio of three is 1 for shape agent (Icing Sugar and dextrin):3:1) it is stirred evenly in desk-top mixer, appropriate 75% ethyl alcohol is added
The softwood of " hand is pinched agglomerating, flicking and dissipated " is made, then single-size is made with oscillating granulator (20 mesh of sieve)；It is dry, it will
It is 6 hours dry that manufactured wet granular sets in heated-air circulation oven (75 DEG C of temperature)；After dry particl cooling, particulate matter is obtained.
Reference examples 1
With embodiment 3 difference lies in：Hawthorn is not added.
9 parts of Radix Angelicae Sinensis, 15 parts of Radix Astragali, 15 parts of pueraria lobata, 9 parts of rhizoma alismatis clean, after clear water cleaning according to prescription proportioning, set more work(
It can extract in the extractor of concentration and recovery unit plus water, under normal pressure refluxing extraction 2 times, the 1st 7~9 times of amount water extractions 1 are small
When, the 2nd time 6~8 times of amount water extract 1 hour；Merge extracting solution twice, staticly settles 24 hours, take supernatant.Supernatant is set
It is 1.20~1.30 that (pressure -0.03~-0.07MPa, 65~75 DEG C of temperature), which is concentrated into relative density at 50 DEG C, in concentration tank
Thick paste；By thick paste, (weight ratio of three is 1 with excipient (Icing Sugar and dextrin):3:1) it is stirred evenly in desk-top mixer,
The softwood of " hand is pinched agglomerating, flicking and dissipated " is made in the ethyl alcohol for being added appropriate 75%, then is made of oscillating granulator (20 mesh of sieve)
Single-size；It is dry, it is 6 hours dry that manufactured wet granular is set into heated-air circulation oven (75 DEG C of temperature)；After dry particl cooling,
Obtain particulate matter.
Preparation character detects
1, particle qualification rate
Particle is set into the mesh vibrating screen whole grain of 10 mesh~60 after granulation, calculates qualification rate, the dry particl sealing after whole grain
Packaging, every bag of 10g.
Granularity qualification rate=can't pass 60 mesh particles/manufactured particle theoretical weight × 100% by 10 mesh
2, friability
It takes the particle of 20 g, 40 mesh or more that the bead of 25 a diameter of 7 mm is added to set together in friability instrument to rotate 100 times,
It collects, crosses 40 mesh sieve, weigh the weight of the upper particle of sieve, calculate particle percentage loss of weight.
3, mobility of particle
The particle 50g after drying is taken, particle is made to be flowed into a culture dish through a funnel, is measured on culture dish after static
The height of particle circular cone is measured the diameter of particle conical base by graph paper（2R）, calculate angle of repose（tgα=H/R）.
1 product result of laboratory test of table
As can be seen from the table, the particle proterties for the granule that this product obtains are preferable, since mountain not being added in reference examples 1
Short, bristly hair or beard prevents the viscosity of extract from being improved, the granule being prepared there are certain mobility of particle bad, particle
The high problem of friability.
The test of pesticide effectiveness
1. experiment material
Drug and reagent
It is to be made in above-described embodiment 3 to return stilbene blood-fat-lowering granule, and distilled water is used in combination to be made into 2 dosage (0.12g/kg, 0.24
G/kg) for use, experiment agents useful for same is all made of Nanjing and builds up bioengineering Co., Ltd product.
Experimental animal
Wistar rat body weights 180-220g;Male 40, is provided by Gansu Chinese of Traditional Chinese Medicine's Experimental Animal Center, is tested
Animal quality quality certification number SCXK (sweet) 2011-0001, animal facility use certificate SYXK (sweet) 2011-0001.High lipid food
Pull together feed corporation,Ltd purchased from Beijing Austria of section.
Laboratory apparatus
Automatic clinical chemistry analyzer, cobas311 automatic clinical chemistry analyzers（Switzerland）.
2. experimental method
Wistar rats are randomly divided into 4 groups, every group 10, respectively basal feed control group（Normal group）, it is high
Fat feed control group, low dose group, high dose group.Base set feeds basal feed, other each groups feed high lipid food.Wistar
Rat freely ingests and drinks water, and daily record is ingested and amount of drinking water.Overnight fasting (12h) after 15d, next day femoral artery take blood, point
From serum, carries out total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C) with automatic clinical chemistry analyzer and examine
It surveys.
Data processing establishes database using SPSS1310 software packages and carries out single factor test variance statistic analysis.
3. result and analysis
Each group Growth in Rats is good in experimentation, and weight shows the trend gradually increased.Control rats high in fat
Weight is significantly higher than blank control group, the reason is that the former has eaten caused by high lipid food；And control group high in fat and 2 dosage groups it
Between weight without significant difference, illustrate to return stilbene blood-fat-lowering granule on rat body weight influence without exception.Survey its TC, TG, LDL-C level, knot
Fruit is shown in Table 3.
Table 2 returns stilbene blood-fat-lowering granule to the influence to hyperlipemia Serum Lipids in Experimental HypercholesterolemicRats
Compared with high lipid food group※P<0.05,※※P<0.01
High lipid food group rat total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C) obviously higher than
Basal feed group, and return stilbene blood-fat-lowering granule low dose and tri- indexs of high dose group rat TC, TG, LDL-C compared with high lipid food group
More have different degrees of decline, wherein high dose group compared with high lipid food group with significant difference（P<0.05 or
0.01）.
Conclusion：Return stilbene blood-fat-lowering granule that there is certain effect for reducing blood fat.
Claims (1)
1. a kind of preparation method of auxiliary antilipemic Chinese herbal medicine health products Radix Angelicae Sinensis Radix Astragali blood-fat-lowering granule, which is characterized in that including as follows
Step：
By weight, 9 parts of Radix Angelicae Sinensis, 15 parts of Radix Astragali, 15 parts of pueraria lobata, 9 parts of rhizoma alismatis, 12 parts of hawthorn are taken, cleaned according to prescription proportioning,
After clear water cleaning, sets and add water in the extractor of multi-functional extraction concentration and recovery unit, refluxing extraction 2 times under normal pressure, the 1st time 8
Amount water extracts 1 hour again, and the 2nd time 7 times of amount water extract 1 hour；Merge extracting solution twice, staticly settle 24 hours, take supernatant,
Supernatant is set to the thick paste for being concentrated into that relative density is 1.25 at 50 DEG C in concentration tank；It is by weight by thick paste, Icing Sugar, dextrin
1:3:1 stirs evenly in desk-top mixer, and the ethyl alcohol for being added 75% is made softwood, then with 20 mesh oscillating granulator system of sieve
At single-size；It is dry, manufactured wet granular is set into heated-air circulation oven 75 DEG C of dryings 6 hours；After dry particl cooling, obtain
Particulate matter.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537545A (en) * | 2003-04-15 | 2004-10-20 | 安徽省医学科学研究所 | Sugar-free type blood-fat-lowering granule, and its prepn. method |
| CN1537544A (en) * | 2003-04-15 | 2004-10-20 | 安徽省医学科学研究所 | Composition of medicine for lowering fat, and its prepn. method |
| CN103251043A (en) * | 2012-03-23 | 2013-08-21 | 山东德圣医药科技有限公司 | Auxiliary hypolipidemic health-care food |
| CN103300367A (en) * | 2013-06-08 | 2013-09-18 | 山西省肿瘤研究所 | Health care drink with lipid-decreasing function and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537545A (en) * | 2003-04-15 | 2004-10-20 | 安徽省医学科学研究所 | Sugar-free type blood-fat-lowering granule, and its prepn. method |
| CN1537544A (en) * | 2003-04-15 | 2004-10-20 | 安徽省医学科学研究所 | Composition of medicine for lowering fat, and its prepn. method |
| CN103251043A (en) * | 2012-03-23 | 2013-08-21 | 山东德圣医药科技有限公司 | Auxiliary hypolipidemic health-care food |
| CN103300367A (en) * | 2013-06-08 | 2013-09-18 | 山西省肿瘤研究所 | Health care drink with lipid-decreasing function and preparation method thereof |
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