CN104622515A - Body fluid electroconductibility sensor - Google Patents
Body fluid electroconductibility sensor Download PDFInfo
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- CN104622515A CN104622515A CN201510090647.2A CN201510090647A CN104622515A CN 104622515 A CN104622515 A CN 104622515A CN 201510090647 A CN201510090647 A CN 201510090647A CN 104622515 A CN104622515 A CN 104622515A
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- 230000005284 excitation Effects 0.000 claims abstract description 8
- 238000005259 measurement Methods 0.000 claims description 19
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- 238000000034 method Methods 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 6
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- 239000002322 conducting polymer Substances 0.000 claims description 2
- 229920001940 conductive polymer Polymers 0.000 claims description 2
- 230000016087 ovulation Effects 0.000 abstract description 9
- 238000012360 testing method Methods 0.000 abstract description 7
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Abstract
A body fluid electroconductibility sensor comprises a signal excitation source, analog conditioning circuits and a sensor probe. The signal excitation source is used for generating alternating signals capable of passing through a human body and synchronous positive and negative clock signals. A current signal output end of the signal excitation source is connected with the sensor probe, so that excitation can be output into the human body via the sensor probe. The synchronous positive and negative signals are connected with corresponding clock signal input ends of the analog conditioning circuits. The analog conditioning circuits are used for receiving the synchronous positive and negative clock signals of the signal excitation source, processing body fluid electroconductibility test signals collected by the sensor probe and outputting analog body fluid voltage signals, namely body fluid electroconductibility signals. The body fluid electroconductibility sensor has the advantage that the variation situation of body fluid ionic concentration affected by ovulatory cycles of corresponding women can be obtained according to varied data information of body fluid electroconductibility effectively, and accordingly, ovulation conditions of the women can be reflected.
Description
Technical field
The present invention relates to medical/domestic medical device field, in particular for ovulation sensing equipment field, specifically a kind of body fluid (saliva, urine, perspiration) conductivity sensor.
Background technology
Women is before ovulation, estrogen level in blood increases, estrogen in blood, by Na+, K+, Ca+ plasma concentration in renin angiotensin II system fading margin body fluid, can cause the synchronism of human body fluid (saliva, perspiration, urine) total amount to change.Therefore change by the synchronism of estrogen and lutropin in the change same period energy direct reaction blood of human body body fluid (saliva, perspiration, urine) ion, and about 5 days predicting ovulation phases can be shifted to an earlier date, and accuracy rate is very high, but seldom used based on the method for testing of this principle at present.Wherein one of reason is exactly market does not also have ripe test women affect method of testing or the instrument of human body fluid (saliva, perspiration, urine) ion concentration change by ovulatory cycle.
Summary of the invention
The object of the invention is for the problems referred to above, a kind of body fluid (saliva, perspiration, urine) conductivity sensor is proposed, effectively can obtain according to the data message of body fluid (saliva, perspiration, urine) electric conductivity change body fluid (saliva, perspiration, urine) the ion concentration situation of change that corresponding women affects by ovulatory cycle, thus reflect female ovulation situation.
Technical scheme of the present invention is:
A kind of body fluid conductivity sensor, it comprises signal driving source, simulated modulation circuit and sensor probe;
Described signal driving source is for generation of by the standard AC signal of human body and synchronous positive and negative clock signal, the AC signal outfan of signal driving source is connected with sensor probe, input human body as excitation by sensor probe, the synchronous positive and negative clock signal of signal driving source is connected with the corresponding clock signal input terminal of simulated modulation circuit;
The synchronous positive and negative clock signal of described simulated modulation circuit receives signals driving source, and process output body fluid analog voltage signal and body fluid electric conductivity signal are carried out to the body fluid conductance measurement signal of sensor probe collection.
Signal driving source of the present invention comprises AC signal generator, current-limiting circuit, fixed amplitude circuit and low delay phase inverter, described AC signal generator produces standard AC signal, its signal output part is successively through current-limiting circuit and fixed amplitude circuit, exported by sensor probe afterwards, the AC signal that described AC signal generator produces also exports the positive clock signals input of simulated modulation circuit to as positive clock signals, the AC signal that AC signal generator produces also exports the signal input part of low delay phase inverter to as positive clock signals, the signal output part of low delay phase inverter exports the negative clock signal input of negative clock signal to simulated modulation circuit.
Standard AC signal of the present invention, comprises standard sine wave, square wave and triangular wave; AC signal generator produces the AC wave shape of more than 500Hz, and amplitude is 100mV-1V.
Simulated modulation circuit of the present invention comprises low pass filter, waveform split circuit and waveform synthetic circuit, one end of described low-pass filter circuit connects the body fluid conductance measurement signal of probe acquires as the input of simulated modulation circuit, the respective signal input of filtered body fluid conductance measurement signal input waveform split circuit, the clock signal input terminal of waveform split circuit and signal driving source corresponding just, negative clock signal outfan is connected, the outfan of waveform split circuit is connected with the signal input part of waveform synthetic circuit, the output of waveform synthetic circuit exports body fluid electric conductivity signal as the output of simulated modulation circuit.
Low pass filter of the present invention adopts second-order low-pass filter, preferred second order Butterworth LPF.
Waveform split circuit of the present invention comprises four analog switches, the electric signal input end of four analog switches connects the body fluid conductance measurement signal of probe acquires respectively, the clock signal input terminal of analog switch one, two connects the positive clock of signal driving source output respectively, the clock signal input terminal of analog switch three, four connects the negative clock of signal driving source output respectively, make the body fluid conductance measurement signal of probe acquires when the positive half cycle of AC signal by analog switch one, two, when negative half period by analog switch three, four.
Waveform synthetic circuit of the present invention comprises buffer one, two and biased comparison circuit, the signal input part of described buffer one connects analog switch one as the input of waveform synthetic circuit, the signal output part of three, the signal input part of buffer two connects analog switch two as another input of waveform synthetic circuit, the signal output part of four, buffer one, two for carrying out coupling synthesis to the waveform of the ac small signal separated and body fluid conductance measurement signal, buffer one, the signal output part of two is all connected with the signal input part of biased comparison circuit, the output of signal output part as waveform synthetic circuit of described biased comparison circuit and the output of sensor, export body fluid electric conductivity signal.
Buffer one, two of the present invention all adopts amplifier follower, preferred rail-to-rail amplifier follower.
Biased comparison circuit of the present invention adopts the comparator be biased.
Sensor probe of the present invention adopts conductor material, and conductor material can adopt medical stainless steel sheet, flexible electrode circuit board, conducting polymer or electrical-conductive nanometer material; The inner surface of sensor probe has surfactant, and outer surface is coated with for antiseptical layers of chrome.
Beneficial effect of the present invention:
Body fluid conductivity sensor of the present invention can obtain the data message of body fluid (saliva, perspiration, urine) electric conductivity change, effectively can obtain according to aforementioned information body fluid (saliva, perspiration, urine) the ion concentration situation of change that corresponding women affects by ovulatory cycle, thus reflect female ovulation situation.
Sensor of the present invention can realize the method for the principle test ovulation physiological period based on the change of female ovulatory period human body fluid (saliva, perspiration, urine) ion concentration.And the more conventional basal body temperature method of testing of the data accuracy recorded by the method, saliva crystallization observational method, cervical mucus observational method are higher, and can shift to an earlier date about 5--7 days predicting ovulation days, this is also in the market can the earliest and the method for Precise detection of ovulation day.
Sensor of the present invention according to test body fluid kind and the needs testing position, can be designed to various form; The cost of manufacture of this sensor is low, is easy to industrialization, has good market prospect.
Simulated modulation circuit of the present invention comprises low pass filter, waveform split circuit and waveform synthetic circuit, simulated modulation circuit is by analyzing the faint body fluid electrical conductance of human body, safety accurately measures the changing features of Human Physiology, this sensor measurement requirement, testee measured before the activity of every day starts.
In waveform split circuit of the present invention, because the body fluid conductance signal that returns from probe sensor and signal driving source and AC signal are synchronous, therefore when positive half cycle at AC signal of the body fluid conductance measurement signal of probe acquires by analog switch one, two, when negative half period by analog switch three, four.Effectively can be separated the positive-negative half-cycle of body fluid conductance signal like this, carry out waveform processing respectively, result accuracy is high; In waveform synthetic circuit afterwards, use buffer isolation digital-to-analogue conversion interface, to make the impact of the input resistance of digital-to-analogue conversion interface drop to minimum, then the positive and negative body fluid conductance measurement signal of analog switch generation in waveform split circuit forms the body fluid conductance measurement signal of complete cycle by comparator by two buffers couplings in addition, and the small-signal of human body fluid conductance can be amplified and quantitative and measurement by the method accurately.
Accompanying drawing explanation
Fig. 1 is theory diagram of the present invention.
Fig. 2 is the theory diagram of signal driving source of the present invention.
Fig. 3 is the theory diagram of simulated modulation circuit of the present invention.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is further illustrated.
As shown in Figure 1, a kind of body fluid conductivity sensor, it comprises signal driving source, simulated modulation circuit and sensor probe;
Described signal driving source is for generation of by the standard AC signal of human body and synchronous positive and negative clock signal, the AC signal outfan of signal driving source is connected with sensor probe, input human body as excitation by sensor probe, the synchronous positive and negative clock signal of signal driving source is connected with the corresponding clock signal input terminal of simulated modulation circuit; Described standard AC signal, comprises standard sine wave, square wave and triangular wave; AC signal generator produces the AC wave shape of more than 500Hz, and amplitude is 100mV-1V.
The synchronous positive and negative clock signal of described simulated modulation circuit receives signals driving source, and process output body fluid analog voltage signal and body fluid electric conductivity signal are carried out to the body fluid conductance measurement signal of sensor probe collection; (input of conditioned signal and standard AC signal can be the sine wave signal of 2kHz, and amplitude is 700mV, and the signal returned from sensor probe is the impedance signal with sinusoidal wave homophase)
During concrete enforcement:
Signal driving source: in order to reduce human body fluid (saliva, perspiration, urine) to the corrosion of sensor probe and damage, on signal driving source, the low-voltage alternating-current small-signal by human body must be adopted.Human body fluid (saliva, perspiration, urine) conductivity sensor adopts the signal generating circuit from producing, corresponding current limliting and fixed ampllitude operation are carried out to signal, and the clock of this signal as simulated modulation circuit is processed the signal of telecommunication returned from sensor probe.In order to avoid the change of electrolyte of human body mucomembranous surface, the waveform of more than 500Hz should be adopted; In order to reduce the corrosion of popping one's head in, should AC signal be adopted, adopting sine wave signal to be example herein; In order to allow electric current by human body mucomembranous surface safely, the small-signal of amplitude limit should be adopted, being no more than 0.5mA by the Small Current Signal of human body herein.
Simulated modulation circuit: the major function of simulated modulation circuit has: low-pass filter circuit, waveform separation and Waveform composition etc.
Simulated modulation circuit also comprises concentration range demarcating module, this module is serially connected in the front end of low-pass filter circuit, comprise TVS amplitude limiter circuit, open circuit amplifies mensuration circuit and mensuration circuit is amplified in short circuit: normal human's body fluid (saliva, perspiration, urine) the electric conductivity excursion drawn by bulk sampling sample, the signal that sensor returns is demarcated, to carry out hardware eliminating to improper method of testing.(the scope of the measured value of hardware scope demarcation and short circuit sensor state and the measured value of off state.Scope of can surveying is 0-2048, and human normal scope estimated value is 300-2000)
Low-pass filter circuit: by low-pass filter circuit, namely second order Butterworth LPF carries out Filtering Processing, so that during high speed analog-to-digital conversion, reduces noise conversion value to the impact of measured value.
Waveform split circuit: the Part I being hardware circuit by waveform split circuit, is mainly used in carrying out positive-negative half-cycle process to the ac small signal that test position returns before entering analog-digital converter.
Signal driving source not only as by the signal source of human body but also the clock source as waveform separation circuit part, to ensure phase invariant when converting waveform.Low delay phase inverter in figure can use the integrated phase inverter of CMOS, such as 74HC04.The measurement conductance signal that probe returns is respectively by analog switch one, two, three, four, wherein analog switch one, two uses positive clock control, three, four negative clock control is used, the conductance signal that such process is measured afterwards when positive half cycle by analog switch one, two, when negative half period by analog switch three, four, completed the process of waveform afterwards by waveform synthetic circuit.
Waveform composition: the Part II being hardware algorithm circuit by waveform synthetic circuit, be mainly used in carrying out coupling synthesis to the waveform of the process of the ac small signal separated, final rear class analog-digital converter of giving carries out data acquisition.
Waveform composition part mainly to the positive and negative buffer respectively by being biased after separation, then compares output.Buffer can use rail-to-rail amplifier follower, and comparison circuit is the comparator be biased.
Waveform after above step and method process, can export the body fluid analog voltage signal that collects as body fluid electric conductivity signal; The most accurately and intuitively react body fluid conductivity level.
Sensor probe: sensor probe uses medical stainless steel sheet, and inner surface uses special scaling powder and surfactant, and surface coating etc. outside, for anticorrosion.
Three are partially integrated in a module, form human body fluid (saliva, perspiration, a urine) conductivity sensor, directly can pass by external interface for the data signal of analog-digital converter conversion.
The part that the present invention does not relate to prior art that maybe can adopt all same as the prior art is realized.
Claims (10)
1. a body fluid conductivity sensor, is characterized in that it comprises signal driving source, simulated modulation circuit and sensor probe;
Described signal driving source is for generation of by the standard AC signal of human body and synchronous positive and negative clock signal, the AC signal outfan of signal driving source is connected with sensor probe, input human body as excitation by sensor probe, the synchronous positive and negative clock signal of signal driving source is connected with the corresponding clock signal input terminal of simulated modulation circuit;
The synchronous positive and negative clock signal of described simulated modulation circuit receives signals driving source, and process output body fluid analog voltage signal and body fluid electric conductivity signal are carried out to the body fluid conductance measurement signal of sensor probe collection.
2. body fluid conductivity sensor according to claim 1, it is characterized in that described signal driving source comprises AC signal generator, current-limiting circuit, fixed amplitude circuit and low delay phase inverter, described AC signal generator produces standard AC signal, its signal output part is successively through current-limiting circuit and fixed amplitude circuit, exported by sensor probe afterwards, the AC signal that described AC signal generator produces also exports the positive clock signals input of simulated modulation circuit to as positive clock signals, the AC signal that AC signal generator produces also exports the signal input part of low delay phase inverter to as positive clock signals, the signal output part of low delay phase inverter exports the negative clock signal input of negative clock signal to simulated modulation circuit.
3. body fluid conductivity sensor according to claim 2, is characterized in that described standard AC signal, comprises standard sine wave, square wave and triangular wave.
4. body fluid conductivity sensor according to claim 1, it is characterized in that described simulated modulation circuit comprises low pass filter, waveform split circuit and waveform synthetic circuit, one end of described low-pass filter circuit connects the body fluid conductance measurement signal of probe acquires as the input of simulated modulation circuit, the respective signal input of filtered body fluid conductance measurement signal input waveform split circuit, the clock signal input terminal of waveform split circuit and signal driving source corresponding just, negative clock signal outfan is connected, the outfan of waveform split circuit is connected with the signal input part of waveform synthetic circuit, the output of waveform synthetic circuit exports body fluid electric conductivity signal as the output of simulated modulation circuit.
5. body fluid conductivity sensor according to claim 4, is characterized in that described low pass filter adopts second-order low-pass filter, preferred second order Butterworth LPF.
6. body fluid conductivity sensor according to claim 4, it is characterized in that described waveform split circuit comprises four analog switches, the electric signal input end of four analog switches connects the body fluid conductance measurement signal of probe acquires respectively, analog switch one, the clock signal input terminal of two connects the positive clock of signal driving source output respectively, analog switch three, the clock signal input terminal of four connects the negative clock of signal driving source output respectively, make the body fluid conductance measurement signal of probe acquires when the positive half cycle of AC signal by analog switch one, two, when negative half period by analog switch three, four.
7. body fluid conductivity sensor according to claim 4, it is characterized in that described waveform synthetic circuit comprises buffer one, two and biased comparison circuit, the signal input part of described buffer one connects analog switch one as the input of waveform synthetic circuit, the signal output part of three, the signal input part of buffer two connects analog switch two as another input of waveform synthetic circuit, the signal output part of four, buffer one, two for carrying out coupling synthesis to the waveform of the ac small signal separated and body fluid conductance measurement signal, buffer one, the signal output part of two is all connected with the signal input part of biased comparison circuit, the output of signal output part as waveform synthetic circuit of described biased comparison circuit and the output of sensor, export body fluid electric conductivity signal.
8. body fluid conductivity sensor according to claim 7, is characterized in that described buffer one, two all adopts amplifier follower, preferred rail-to-rail amplifier follower.
9. body fluid conductivity sensor according to claim 7, is characterized in that described biased comparison circuit adopts the comparator be biased.
10. body fluid conductivity sensor according to claim 1, it is characterized in that described sensor probe adopts conductor material, conductor material can adopt medical stainless steel sheet, flexible electrode circuit board, conducting polymer or electrical-conductive nanometer material; The inner surface of sensor probe has surfactant, and outer surface is coated with for antiseptical layers of chrome.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510090647.2A CN104622515B (en) | 2015-02-27 | 2015-02-27 | Body fluid electroconductibility sensor |
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| CN201510090647.2A CN104622515B (en) | 2015-02-27 | 2015-02-27 | Body fluid electroconductibility sensor |
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| CN104622515A true CN104622515A (en) | 2015-05-20 |
| CN104622515B CN104622515B (en) | 2017-05-17 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112630268A (en) * | 2020-11-26 | 2021-04-09 | 燕山大学 | Bipolar miniature ion concentration sensor and measurement system thereof |
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|---|---|---|---|---|
| CN1073350A (en) * | 1991-11-13 | 1993-06-23 | 莱恩技术魏兰及卡斯帕公司 | Method for measuring body fluid conductivity and measuring probe used therefor |
| CN1127628A (en) * | 1995-01-28 | 1996-07-31 | 中国医学科学院基础医学研究所 | Organism body fluid distribution measuring analyzer |
| US20010010467A1 (en) * | 2000-01-31 | 2001-08-02 | Tanita Corporation | Bioelectrical impedance measuring apparatus constructed by one-chip integrated circuit |
| CN2669791Y (en) * | 2003-08-05 | 2005-01-12 | 彭飞 | Human body impedance measuring devices |
| US20080045854A1 (en) * | 2006-08-16 | 2008-02-21 | Pan Weichao | Human body impedance measurement device and its application |
| CN204542210U (en) * | 2015-02-27 | 2015-08-12 | 江苏矽望电子科技有限公司 | body fluid conductivity sensor |
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2015
- 2015-02-27 CN CN201510090647.2A patent/CN104622515B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1073350A (en) * | 1991-11-13 | 1993-06-23 | 莱恩技术魏兰及卡斯帕公司 | Method for measuring body fluid conductivity and measuring probe used therefor |
| CN1127628A (en) * | 1995-01-28 | 1996-07-31 | 中国医学科学院基础医学研究所 | Organism body fluid distribution measuring analyzer |
| US20010010467A1 (en) * | 2000-01-31 | 2001-08-02 | Tanita Corporation | Bioelectrical impedance measuring apparatus constructed by one-chip integrated circuit |
| CN2669791Y (en) * | 2003-08-05 | 2005-01-12 | 彭飞 | Human body impedance measuring devices |
| US20080045854A1 (en) * | 2006-08-16 | 2008-02-21 | Pan Weichao | Human body impedance measurement device and its application |
| CN204542210U (en) * | 2015-02-27 | 2015-08-12 | 江苏矽望电子科技有限公司 | body fluid conductivity sensor |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112630268A (en) * | 2020-11-26 | 2021-04-09 | 燕山大学 | Bipolar miniature ion concentration sensor and measurement system thereof |
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Application publication date: 20150520 Assignee: HANGZHOU WELBEING MEDICAL TECHNOLOGY CO.,LTD. Assignor: CYNOWARE ELECTRONICS Inc. Contract record no.: 2016320000227 Denomination of invention: Body fluid electroconductibility sensor License type: Exclusive License Record date: 20161228 |
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Denomination of invention: Body fluid conductivity sensor Granted publication date: 20170517 Pledgee: Nanjing Bank Co.,Ltd. Nanjing Financial City Branch Pledgor: CYNOWARE ELECTRONICS Inc. Registration number: Y2024980015258 |