CN104610258A - 一类含酰胺和甲氧苯结构的FXa抑制剂、制备方法及其用途 - Google Patents
一类含酰胺和甲氧苯结构的FXa抑制剂、制备方法及其用途 Download PDFInfo
- Publication number
- CN104610258A CN104610258A CN201510082544.1A CN201510082544A CN104610258A CN 104610258 A CN104610258 A CN 104610258A CN 201510082544 A CN201510082544 A CN 201510082544A CN 104610258 A CN104610258 A CN 104610258A
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- CN
- China
- Prior art keywords
- compound
- fxa inhibitor
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- obtains
- formula
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- 0 C*1C[C@@]2NCCC[C@@]2C1 Chemical compound C*1C[C@@]2NCCC[C@@]2C1 0.000 description 4
- KSCPLKVBWDOSAI-RQJHMYQMSA-N C1NC[C@@H]2NCCC[C@H]12 Chemical compound C1NC[C@@H]2NCCC[C@H]12 KSCPLKVBWDOSAI-RQJHMYQMSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Description
化合物 | IC50(nM) |
Edoxaban | 4.0 |
参比化合物D-1 | 7.8 |
化合物I-1 | 3.4 |
化合物I-2 | 4.5 |
Claims (4)
Priority Applications (1)
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CN201510082544.1A CN104610258B (zh) | 2015-02-14 | 2015-02-14 | 一类含酰胺和甲氧苯结构的FXa抑制剂、制备方法及其用途 |
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CN201510082544.1A CN104610258B (zh) | 2015-02-14 | 2015-02-14 | 一类含酰胺和甲氧苯结构的FXa抑制剂、制备方法及其用途 |
Publications (2)
Publication Number | Publication Date |
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CN104610258A true CN104610258A (zh) | 2015-05-13 |
CN104610258B CN104610258B (zh) | 2016-03-30 |
Family
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CN201510082544.1A Active CN104610258B (zh) | 2015-02-14 | 2015-02-14 | 一类含酰胺和甲氧苯结构的FXa抑制剂、制备方法及其用途 |
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CN (1) | CN104610258B (zh) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1420882A (zh) * | 1999-07-28 | 2003-05-28 | 阿温蒂斯药物公司 | 取代的氧代氮杂杂环基化合物 |
WO2006006490A1 (ja) * | 2004-07-08 | 2006-01-19 | Ono Pharmaceutical Co., Ltd. | スピロ化合物 |
US20070049587A1 (en) * | 2005-09-01 | 2007-03-01 | Zbinden Katrin G | Factor Xa inhibitors |
CN103936763A (zh) * | 2013-01-18 | 2014-07-23 | 中国科学院上海药物研究所 | 噁唑烷酮类化合物及其制备方法和用途 |
CN104311537A (zh) * | 2014-09-19 | 2015-01-28 | 广东东阳光药业有限公司 | 含有嘧啶酮乙酰基取代基吡唑类化合物及其组合物及用途 |
-
2015
- 2015-02-14 CN CN201510082544.1A patent/CN104610258B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1420882A (zh) * | 1999-07-28 | 2003-05-28 | 阿温蒂斯药物公司 | 取代的氧代氮杂杂环基化合物 |
WO2006006490A1 (ja) * | 2004-07-08 | 2006-01-19 | Ono Pharmaceutical Co., Ltd. | スピロ化合物 |
US20070049587A1 (en) * | 2005-09-01 | 2007-03-01 | Zbinden Katrin G | Factor Xa inhibitors |
CN103936763A (zh) * | 2013-01-18 | 2014-07-23 | 中国科学院上海药物研究所 | 噁唑烷酮类化合物及其制备方法和用途 |
CN104311537A (zh) * | 2014-09-19 | 2015-01-28 | 广东东阳光药业有限公司 | 含有嘧啶酮乙酰基取代基吡唑类化合物及其组合物及用途 |
Non-Patent Citations (1)
Title |
---|
邢峻豪等: "抗血栓药物的研究进展", 《药学进展》 * |
Also Published As
Publication number | Publication date |
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CN104610258B (zh) | 2016-03-30 |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: FXa inhibitor containing amide and methoxybenzene structures as well as preparation method and application thereof Effective date of registration: 20170816 Granted publication date: 20160330 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20190604 Granted publication date: 20160330 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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TR01 | Transfer of patent right | ||
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Effective date of registration: 20190805 Address after: 233000 Yuhui District, Bengbu City, Anhui Province, No. 1750 Shengli West Road, No. 316 Pioneering Building, Huineng Small and Micro Enterprise Pioneering Center Patentee after: Bengbu Dingrong Science and Technology Information Consulting Co., Ltd. Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |