CN104585197A - Compound bactericide - Google Patents
Compound bactericide Download PDFInfo
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- CN104585197A CN104585197A CN201410575826.0A CN201410575826A CN104585197A CN 104585197 A CN104585197 A CN 104585197A CN 201410575826 A CN201410575826 A CN 201410575826A CN 104585197 A CN104585197 A CN 104585197A
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- polyoxin
- acid amides
- ether acid
- fluorobenzene ether
- suspending agent
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Abstract
The invention belongs to the technical field of farm chemical and relates to a compound bactericide. The compound bactericide is characterized in that active components comprise fluorophenyl ether amide and polyoxin. The compound bactericide has substantial synergism, has a low use amount, delays production of resistance to the bactericide, prolongs a persistent period and is environmentally friendly.
Description
Technical field the invention belongs to technical field of pesticide, contains the composite bactericide with synergistic effect of fluorobenzene ether acid amides and polyoxin specifically.
Background technology
Fluorobenzene ether acid amides is Central China Normal University's pyrazol acid amide compounds newly developed, and epidemic disease, the downy mildew common to cucumber, tomato, potato, rice sheath blight disease has extraordinary effect, and active ingredient is novel, non-resistant.
Polyoxin (polyoxin) is the metabolite that streptomyces aureus produces, and belongs to broad-spectrum antibiotics series bactericidal agent.There is good Uptake and translocation effect.Its mechanism of action is the chitinous biosynthesis of interference germ cell wall, makes somatic cells wall can not carry out biosynthesis and causes germ dead.This composition also has the effect suppressing germ to produce spore and scab expansion.This composition is mainly used in control alternaria leaf spot of apple, ring spot, Pear black spot, grape grey mould, strawberry, cucumber, the powdery mildew of muskmelon, downy mildew, black fleck disease of ginseng, Alternaria alternate, the banded sclerotial blight of paddy rice etc. ten various crop disease.
Rice sheath blight disease (Rhizoctorzia solani), also known as moire disease, is infected by Rhizoctonia solani Kuhn and fall ill, and how to fall ill under high temperature, super-humid conditions.Banded sclerotial blight is serious in the harm of south rice region, is one of Major Diseases in current Rice Production.This disease can make paddy rice not ear, and particle weight declines, and has a strong impact on rice yield.
Summary of the invention
The object of this invention is to provide and a kind ofly there is synergistic effect and the bactericidal composition of safety and environmental protection, compared with existing pesticide control, realize improving drug effect, decreasing pollution, the object that reduces costs.Be specifically related to the composite bactericide of fluorobenzene ether acid amides and polyoxin.
Utilize above-mentioned composite bactericide, be equipped with the known auxiliary agent of those skilled in that art, make formulation of the present invention with the known method of those skilled in that art, comprise suspending agent, dispersible oil-suspending agent, water dispersible granules.
In above-mentioned composite bactericide, the weight ratio of fluorobenzene ether acid amides and polyoxin is 1:60-60:1.
Above-mentioned composite bactericide has following characteristics: the 1. advanced environmental protection of formulation, and environmental pollution is little; 2. bactericidal action is strong, not easily develops immunity to drugs; 3. two kinds of compositions are composite, have synergistic effect; 4. active ingredient is advanced, non-resistant.
Embodiment
For determining fluorobenzene ether acid amides and the composite synergistic effect of polyoxin two kinds of active ingredients, first applicant uses these two kinds of compositions to carry out indoor biometrics test, test method and result as follows:
First after analyzing the action character of two kinds of active ingredients, the raw object surveyed is decided to be thanatephorus cucumeris(frank) donk (Thanatephoruscucumeris) by us, this Pseudomonas Basidiomycotina fungi, sclerotium is dark brown, bacterium colony is light brown to taupe mildew, and this bacterium can cause rice sheath blight disease.
The test method of indoor biometrics: adopt the inhibitory action that growth rate method mensuration medicament grows rice sheath blight disease mycelia, and with reference to NYT 1156.6-2006.On the basis of preliminary experiment, from each medicament, design 5 concentration within the scope of 10%-90% are reached to germ mycelial growth inhibition rate, it is for subsequent use by the 95% former medicine of fluorobenzene ether acid amides and the former medicine of 70% polyoxin with methyl alcohol to be first that solvent is made into the liquid of series concentration, then liquid is joined in 1% ratio in the PDA medium melting also cool to room temperature, after fully shaking up, pour in the culture dish (Φ 90mm) of sterilizing and make band medicine flat board, often process and repeat, to add the process of sterile water for blank for four times; With card punch (Φ 5mm) the picking Rhizoctonia solani Kuhn bacterium cake of sterilizing, mycelia faces down aseptic inoculation in the central authorities of band medicine flat board, be inverted in the interior cultivation of constant incubator of 25 DEG C, adopt right-angled intersection method to measure colony diameter after cultivating 6d, calculate the EC of each medicament to pathogen
50, and calculate toxicity index according to the following equation, compare virulence and the bacteriostasis of different agents.Former medicine used is tested in above-mentioned raw test and reagent is all bought from other producers.
The co-toxicity coefficient method representation that the co-toxicity of mixture preparation adopts Sun Yun abundant:
The theoretical toxicity index TTI=∑ of mixture preparation (percentage of this pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture).
Be synergistic effect when co-toxicity coefficient CTC is greater than 120, being antagonism when being less than 80, is addition time between 80-120.
Indoor biometrics test data sees the following form:
Table 1 fluorobenzene ether acid amides, polyoxin and different ratio thereof are to the measurement result of rice sheath blight disease co-toxicity coefficient
Analyze above-mentioned data to draw, when fluorobenzene ether acid amides and polyoxin are composite in varing proportions, the co-toxicity coefficient (CTC) of formula is all greater than 120, the prevention and control capability of rice sheath blight disease is had to the synergistic effect of different proportion, wherein the synergy between 1:5-5:1 namely between proportioning four to proportioning six of fluorobenzene ether acid amides and polyoxin is the most remarkable, the composite favourable agents becoming the water prevention rice sheath blight of visible fluorobenzene ether acid amides and polyoxin.
Tested by indoor biometrics, determine fluorobenzene ether acid amides and polyoxin two kinds of active ingredients composite after, have good synergistic effect, below by way of instantiation in order to further describe the present invention, but the present invention is absolutely not only only limitted to these embodiments following.Percentage in formula is all weight percentage, and the former medicine used and auxiliary agent are other producers and buy.
Formulation examples is as follows:
Dispersible the requirement of oil-suspending agent: according to recipe requirements, take methylated vegetable oil as medium, fluorobenzene ether acid amides and polyoxin two kinds of active ingredients and dispersant, wetting agent, thickener, emulsifier for mixing is even, put into sand mill grinding evenly, obtain dispersibling oil-suspending agent.
The requirement of suspending agent: according to recipe requirements take water as medium, active ingredient, wetting agent, dispersant, thickener, defoamer etc. is added in sand mill and grinds, after add emulsification in high-shear emulsifying still, obtained suspending agent.
The configuration requirement of water dispersible granules: according to recipe requirements, after fluorobenzene ether acid amides and polyoxin two kinds of active ingredients are fully mixed with wetting agent, dispersant and filler, be ground into trickle powdery solid, be then prepared from through operations such as engagement, granulation, drying, screenings.
Example one, 30.5% fluorobenzene ether acid amides polyoxin suspending agent
Example two, 31% fluorobenzene ether acid amides polyoxin dispersibles oil-suspending agent
Example three, 22% fluorobenzene ether acid amides polyoxin water dispersible granules
Example four, 6% fluorobenzene ether acid amides polyoxin suspending agent
Example five, 10% fluorobenzene ether acid amides polyoxin dispersibles oil-suspending agent
Example six, 24% fluorobenzene ether acid amides polyoxin water dispersible granules
Example seven, 11% fluorobenzene ether acid amides polyoxin suspending agent
Example eight, 3.1% fluorobenzene ether acid amides polyoxin dispersibles oil-suspending agent
Example nine, 61% fluorobenzene ether acid amides polyoxin water dispersible granules
Select above example to carry out the field trial of the water prevention rice sheath blight, determine the effect of the formula water prevention rice sheath blight; Simultaneously by the Contrast on effect with fluorobenzene ether acid amides and polyoxin single dose, verify composite after synergistic effect.Concrete test method data are as follows:
6% fluorobenzene ether acid amides polyoxin suspending agent and other preparation do the field control effectiveness test of the water prevention rice sheath blight.Test reference standard GB/T17980.20-2000, test site is Shi Mei village of xiangtan, hunan province county, and the time is on September 2nd, 2014, and test each process three repetition, community randomized arrangement, each plot area is 60m
2, adopt back-pack electric compression sprayer, dispenser was sunny calm for the same day, and the planting habit of planting habit all with local of all communities is identical, records the synoptic data on the dispenser same day and a week thereafter, specific as follows:
Table 2 duration of test meteorological data
Investigation method is: each community diagonal 5 sampling, often adjacent 5 clumps of paddy rice of investigation, totally 25 clumps, before carrying out medicine, radix is investigated, investigation in the 7th day, 15 days after dispenser, record investigation total strain number, diseased plant number, sick progression, calculate preventive effect, and carry out the new multipole difference analysis of Deng Kenshi.
The grade scale of disease index:
0 grade: complete stool is anosis
1 grade: count the 4th leaf with lower blade, leaf sheath morbidity from top
3 grades: count the 3rd leaf with lower blade, leaf sheath morbidity from top
5 grades: count second leaf with lower blade, leaf sheath morbidity from top
7 grades: from top with lower blade, leaf sheath morbidity
9 grades: complete stool morbidity is withered
Table 36% fluorobenzene ether acid amides polyoxin suspending agent and different agents are to the preventive effect of rice sheath blight disease
As can be seen from above-mentioned data, fluorobenzene ether acid amides and polyoxin complex preparation, after medicine, 7 days preventive effects are all more than 76%, and 24% fluorobenzene ether amide suspending agents, 7 days preventive effects after medicine are 51.04%, the preventive effect of 10% polyoxin aqueous solution is 43.01%, and visible complex preparation is compared with single dose, and preventive effect difference is extremely remarkable, after two kinds of active ingredients are composite, there is good synergistic effect.And after medicine 15 days, all complex preparations have all exceeded 86% to the preventive effect of rice sheath blight disease, and complex preparation can well improve drug effect, extend the lasting period, alleviate the amount of labour of peasant, have very high practicality.
Claims (2)
1. a composite bactericide, is characterized in that: active component is made up of fluorobenzene ether acid amides and polyoxin, and the weight ratio of described fluorobenzene ether acid amides and polyoxin is 1:60 ~ 60:1.
2. composite bactericide according to claim 1, is characterized in that: make suspending agent by active component and auxiliary material, dispersible oil-suspending agent, water dispersible granules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410575826.0A CN104585197A (en) | 2014-10-25 | 2014-10-25 | Compound bactericide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410575826.0A CN104585197A (en) | 2014-10-25 | 2014-10-25 | Compound bactericide |
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| CN104585197A true CN104585197A (en) | 2015-05-06 |
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| CN201410575826.0A Pending CN104585197A (en) | 2014-10-25 | 2014-10-25 | Compound bactericide |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106614694A (en) * | 2016-12-29 | 2017-05-10 | 成都格瑞赛斯科技有限公司 | Dinotefuran-containing insecticidal and bactericidal composition for preventing and treating rice diseases and pests |
| CN106614722A (en) * | 2016-12-29 | 2017-05-10 | 成都格瑞赛斯科技有限公司 | Chloramine phosphorus-containing insecticidal and bactericidal composition for preventing and treating rice diseases and pests |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1443045A1 (en) * | 1996-07-24 | 2004-08-04 | Bayer CropScience AG | Carbanilide used as pesticide |
| CN102415392A (en) * | 2011-12-23 | 2012-04-18 | 江阴苏利化学有限公司 | Germicide composition containing boscalid and cymoxanil |
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
-
2014
- 2014-10-25 CN CN201410575826.0A patent/CN104585197A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1443045A1 (en) * | 1996-07-24 | 2004-08-04 | Bayer CropScience AG | Carbanilide used as pesticide |
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
| CN102415392A (en) * | 2011-12-23 | 2012-04-18 | 江阴苏利化学有限公司 | Germicide composition containing boscalid and cymoxanil |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106614694A (en) * | 2016-12-29 | 2017-05-10 | 成都格瑞赛斯科技有限公司 | Dinotefuran-containing insecticidal and bactericidal composition for preventing and treating rice diseases and pests |
| CN106614722A (en) * | 2016-12-29 | 2017-05-10 | 成都格瑞赛斯科技有限公司 | Chloramine phosphorus-containing insecticidal and bactericidal composition for preventing and treating rice diseases and pests |
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Application publication date: 20150506 |