CN104524093A - Chinese herb perfusion fluid for treating endometritis of milk cows - Google Patents
Chinese herb perfusion fluid for treating endometritis of milk cows Download PDFInfo
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Abstract
Chinese herb perfusion fluid for treating the endometritis of milk cows comprises, by weight, 5-7 parts of herba leonuri, 4-6 parts of heartleaf houttuynia herbs, 2-4 parts of dahurian patrinia herbs, 2-4 parts of common cnidium fruits, 2-4 parts of radix sophorae flavescentis, 2-4 parts of sargentg loryvine stems, 2-4 parts of fructus liquidambaris, 1-3 parts of radix achyranthis bidentatae, 1-3 parts of herba hyperici japonica, 1-2 parts of rhizoma cyperi, 1-2 parts of pollen typhae and 1-2 parts of liquorice. The Chinese herb perfusion fluid is used for treating the endometritis of the milk cows and is short in treatment course, low in cost, high in cure rate, safe, free of toxic and side effects and convenient to use.
Description
Technical field
The present invention relates to the Chinese herbal medicine of milk cattle cultivating, be specifically related to a kind of Chinese herbal medicine perfusate for the treatment of cow endometritis.
Background technology
Cow endometritis is the common disease in cow reproductive system, and sickness rate, up to 20%-40%, seriously affects reproductive capacity and the fertility performance of milch cow, causes the economic benefit of milk cow production to reduce, and hinders the sound development of dairy.Cow endometritis causes milch cow infertile, increases tire spacing, reduces the output of milk, causes huge economic loss to milk cow production.The pathogen of cow endometritis reaches kind more than 80, mainly contains antibacterial, Mycoplasma, fungus and virus, and antibacterial is mainly based on staphylococcus and streptococcus.At present, what the employing for the treatment of cow endometritis was more is Antibiotics Western medicine, although have certain curative effect, shortcoming is that Drug resistance and side effect are comparatively serious, and in meat and milk, have chemicals residual, brings potential threat to human health.Chinese herbal medicine have natural, have no side effect, residual without chemicals, not easily the feature such as to develop immunity to drugs.Prior art discloses the Chinese herbal medicine for the treatment of cow endometritis, but its weak curative effect, cure rate is low, and the course for the treatment of is long and cost is high.
Summary of the invention
The object of the invention is to for the problems referred to above, provide a kind of easy to use, cost is low, effectively can treat the Chinese herbal medicine perfusate of cow endometritis.
Technical scheme of the present invention is: a kind of Chinese herbal medicine perfusate for the treatment of cow endometritis, and it is made up of the crude drug of following weight parts: Herba Leonuri 5 parts-7 parts, Herba Houttuyniae 4 parts-6 parts, Herba Patriniae 2 parts-4 parts, Fructus Cnidii 2 parts-4 parts, Radix Sophorae Flavescentis 2 parts-4 parts, Caulis Sargentodoxae 2 parts-4 parts, Fructus Liquidambaris 2 parts-4 parts, Radix Achyranthis Bidentatae 1 part-3 parts, Herba Hyperici Japonici 1 part-3 parts, Rhizoma Cyperi 1 part-2 parts, Pollen Typhae 1 part-2 parts, 1 part-2 parts, Radix Glycyrrhizae.
The preferred feedstock medicine weight portion of the Chinese herbal medicine perfusate of cost treatment cow endometritis processed is: Herba Leonuri 7 parts, Herba Houttuyniae 6 parts, Herba Patriniae 4 parts, Fructus Cnidii 3 parts, Radix Sophorae Flavescentis 3 parts, Caulis Sargentodoxae 3 parts, Fructus Liquidambaris 3 parts, Radix Achyranthis Bidentatae 3 parts, Herba Hyperici Japonici 3 parts, Rhizoma Cyperi 2 parts, Pollen Typhae 2 parts, 1 part, Radix Glycyrrhizae.
The preparation method of the Chinese herbal medicine perfusate of this treatment cow endometritis is carried out according to the following steps:
(1) take Herba Leonuri, Herba Houttuyniae, Herba Patriniae, Fructus Cnidii, Radix Sophorae Flavescentis, Caulis Sargentodoxae, Fructus Liquidambaris, Radix Achyranthis Bidentatae, Herba Hyperici Japonici, Rhizoma Cyperi, Pollen Typhae, Radix Glycyrrhizae 12 taste herbal decoction piece by weight respectively, and be ground into Chinese herbal medicine coarse powder respectively;
(2) Herba Houttuyniae, Herba Patriniae, Radix Sophorae Flavescentis, Caulis Sargentodoxae, Fructus Liquidambaris, Radix Achyranthis Bidentatae, Herba Hyperici Japonici, Rhizoma Cyperi, Radix Glycyrrhizae Chinese herbal medicine coarse powder is got, the Chinese herbal medicine coarse powder gross weight obtained by step (1) 7 extraordinarily injection water soak 20min-30min, heating decocts 25min-35min, add Herba Leonuri, Fructus Cnidii, Pollen Typhae Chinese herbal medicine coarse powder decoction 25min-35min again, incline to and boil liquid for the first time, the Chinese herbal medicine coarse powder gross weight obtained by step (1) again 5 extraordinarily injection water decoct twice, each decoction 25min-35min, obtains second time and boils liquid and boil liquid for the third time;
(3) what combining step (2) obtained boils liquid three times, filters, and is concentrated into every milliliter of injection water containing crude drug 1g, obtains concentrating and boils liquid;
(4) step (3) is obtained concentrated to boil the concentration that liquid adds 3 times of weight be the ethanol of 95%, stir while adding, leave standstill 24h, removing precipitate and reclaims ethanol, is concentrated into every milliliter of injection water and contains crude drug 2g, obtain concentrated medicament;
(5) pH dripping the concentrated medicament that dilute sodium hydroxide makes step (4) obtain reaches 7.0, active carbon is added by 0.15% of described concentrated medicament weight, boil 25-30min, place 12h, respectively add benzyl alcohol and tween 80 by 1% of described concentrated medicament weight, stir evenly, G-3 sintered glass funnel filters, and filtrate complements to every milliliter of injection water containing crude drug 2g with injection water, fill, sterilizing, the i.e. Chinese herbal medicine perfusate of obtained this treatment cow endometritis.
In the Chinese herbal medicine perfusate prescription of this treatment cow endometritis, each component pharmacological effect is:
Herba Leonuri effect: Herba Leonuri another name Herba Leonuri Artemisia, Herba Leonuri Chinese mugwort, Flos Carthami Chinese mugwort, Herba Leonuri, Herba Leonuri, teosinte, Fructus Seu Herba Pubescentis, ferrum fiber crops do.Nature and flavor are bitter, pungent, are slightly cold, return liver, pericardium channel.Containing leonurine, stachydrine, leonuridine, leonurinine, linolenic acid, β-linolenic acid, lauric acid, oleic acid, benzoic acid, globulariacitrin, Fumaric acid, sterol, vitamin A etc., in addition also containing arginine, 4-guanidine radicals-n-butyl alcohol, 4-guanidine radicals-butanoic acid, stachyose.Tool is invigorated blood circulation, effect of blood stasis dispelling, the water that disappears.For vaginal bleeding during pregnancy difficult labour, retention of placenta, abdominal pain due to blood stasis, rushes down blood, carbuncle skin infection.
Herba Houttuyniae effect: Herba Houttuyniae another name Cen grass, purple back of the body Herba Houttuyniae.Cold nature, bitter in the mouth, return lung, liver, bladder, large intestine channel.Containing volatile oil, include antibiotic effective ingredient decanoylacetaldehyde, lauryl aldehyde, a-pinene and linalool, methyl n-nonyl ketone, lauro lene, myrcene, limonene, borneol acetate, Flos Caryophylli alkene, afzerin, hyperin, globulariacitrin.Tool heat-clearing and toxic substances removing, effect of inducing diuresis to remove edema.For pneumonia, lung abscess, hematodiarrhoea, malaria, edema, carbuncle, proctoptosis, eczema, tinea alba, scabies.
Herba Patriniae effect: Herba Patriniae another name Herba Ixeritis chinensis, Herba Sonchi Oleracei, little Herba Lactucae versicoloris dish, Herba Patriniae, Ixeris denticulata, Herba Lactucae formosanae dish, Chinese cabbage, Herba Malvastri Coromandeliani etc.Nature and flavor are worked hard, be slightly cold, and return liver, stomach, large intestine channel.Containing volatile oil, potassium myronate, oleanolic acid, hederagenin, cupreol-β-D-Glucose glycoside, alkaloid, tannin, starch.There is heat-clearing and toxic substances removing, effect of evacuation of pus removing blood stasis with potent drugs.For acute appendicitis, dysentery, conjunctival congestion and swelling pain, carbuncle scabies etc.
Fructus Cnidii effect: Fructus Cnidii calls wild Fructus Foeniculi, cnidium monnieri reality, cnidium monnieri core, Serpentis pearl, corn radish bowl, Tu Zihua, Serpentis rice etc.Nature and flavor are pungent, bitter, and temperature, returns kidney channel.Containing volatile oil, main component is pinene, camphene, the acid of different one-tenth borneol acetate, isoborneol; Again containing osthole, cnidimine, different Herba Saxifragae case, bergapton, columbianetin and angelate, acetas, mouth isovalerate, cnidiadin, isobutyl acyloxy o-acetylcolumbianetin; Also containing cnidium monnieri cloudy element, isopimpinellin, alloimperatorin, xanthotoxol, ammidin etc.Tool heat clearing and damp drying, killing parasites for relieving itching, removing toxic substances pain relieving, effect of anticorrosion detumescence.For cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago etc.
Radix Sophorae Flavescentis effect: Radix Sophorae Flavescentis another name ground Chinese scholartree, Hao Hanzhi, Albizzia kalkora, wild Chinese scholartree.Nature and flavor are bitter, cold, GUIXIN, liver, stomach, large intestine, urinary bladder channel.Containing alkaloid as matrine, oxymatrine, N-is oxidized sophocarpine.Also containing multiple flavone compound alcohol as new in Radix Sophorae Flavescentis, Radix Sophorae Flavescentis chalcone derivative, Radix Sophorae Flavescentis chalcone derivative alcohol, Radix Sophorae Flavescentis alcohol, kurarinone, kurarinone etc.In addition, triterpenoid saponin is also contained as Radix Sophorae Flavescentis Saponin, soyasaponins etc.Tool heat clearing and damp drying, parasite killing, effect of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, eczema, eczema, skin pruritus, scabies leprosy etc.
Caulis Sargentodoxae effect: Caulis Sargentodoxae another name Caulis seu Radix Schisandrae Henryi, Caulis Sargentodoxae, DAHUOXUE, large blood lead to.Nature and flavor are bitter, flat, return liver, large intestine channel.Containing emodin, physcione, cupreol, daucosterol, stearic acid, salidroside, dextrorotation syringaresinol diglucoside, dextrorotation dihydroguaiaretic acid, chrysophanol, vanillic acid, protocatechuic acid and P-coumaric acid-p-hydroxyphenylethanol ester and Caulis Sargentodoxae polysaccharide.Tool promoting blood circulation to remove obstruction in the collateral, relieve internal heat dissipating blood stasis, effect of wind dispelling insecticide.For abdominalgia with intestinal abscess, traumatic injury, Fengshi Guanjie pain etc.
Fructus Liquidambaris effect: ball, sweetgum fruit, maple fruit, chicken maple, Japanese maple, great Ye maple, clematis stem etc. in Fructus Liquidambaris another name Fructus Liquidambaris maple reality, maple.Nature and flavor are bitter, flat, return Liver and kidney warp.Containing the nor-oleanonic acid of 28-, styracin, left-handed cinnamic acid borneol acetate, epoxy styracin, different epoxy styracin, trans-Caryophyllene oxide, Fructus Liquidambaris keto acid, 24-ethyl gallbladder steroid-5-enol.Tool dispelling, collateral-activating, diuretic stimulates the menstrual flow, effect of promoting flow of QI and blood.For arthralgia, numbness contracture, edema distension, breast is few.
Radix Achyranthis Bidentatae effect: Radix Achyranthis Bidentatae another name Radix Achyranthis Bidentatae, cattle stem, foot this pedal, cherish sunset, bosom knee joint, Radix Achyranthis Bidentatae, Red Radix Achyranthis Bidentatae, stickweed daughter root etc.Nature and flavor are sweet, bitter, sour, flat, return liver, kidney channel.Containing triterpenoid saponin, again containing multiple polysaccharide, also containing ecdysterone, inokosterone, rubrosterone and arginine, glycine, serine, aspartic acid, glutamic acid, threonine, proline, tyrosine, tryptophan, valine, phenylalanine, leucine and alkaloids and Coumarins compound.Tool dissipating blood stasis blood, effect of subduing inflammation.For soreness of waist and knee joint, flaccidity and weakness of the lower limbs, puerperal abdominal pain due to blood stasis, retention of placenta, pyretic stranguria, stranguria with blood, traumatic injury, carbuncle malignant boil, laryngopharynx swelling and pain etc.
Herba Hyperici Japonici effect: Herba Hyperici Japonici another name Herba Hyperici Japonici, Rhizoma et radix valerianae, Stellaria alsine Grim., Herba Artemisiae Anomalae.Nature and flavor bitter in the mouth, flat, return liver, gallbladder meridian.Containing quercitrin, Isoquercitrin, Quercetin-7-rhamnoside-pentahydroxyflavone-7-rhamnoside, Herba Hyperici Japonici spirit plain Herba Hyperici Japonici rib element A, B, Filixic Acids.Tool dampness removing jaundice eliminating, heat-clearing and toxic substances removing, effect of promoting blood circulation and detumescence.For jaundice pyretic stranguria, malignant boil, toxic swelling etc.
Rhizoma Cyperi effect: Rhizoma Cyperi calls fragrant head grass, later blue or green, passeris montani saturati head perfume.
http:// baike.***.com/picture/147375/147375/2658492/63d9f2d357 2c11df902565da632762d0f603c257.html? fr=lemm a & ct=coverthe pungent micro-hardship of nature and flavor is sweet, flat, returns liver, tri-jiao channel.Containing glucose, fructose, starch, volatile oil.Rhizoma Cyperi alkene, cyperol, isocyperol is mainly in volatile oil, and containing nopinene, camphene, 1, 8-Cineole, limonene, selinatriene, β-selinene, α-cyperone, β-cyperone, cyperolone, rotundone, epoxyguaine azulene ketone, kobusone and isokobusone.Also containing triterpenes, flavonoid and alkaloid etc.Tool is regulated the flow of vital energy resolving depression, menstruction regulating and pain relieving, antiabortive effect.For distending pain over the hypochondrium, mammary swelling is educated, hernia pain, gastral cavity abdomen feeling of fullness pain, belch acid regurgitation, and vomiting and nausea, frequent fetal movement dyspepsia, breast gastral cavity painful abdominal mass is vexed.
Pollen Typhae effect: Pollen Typhae another name Pu li pollen, Pu Hua, Spica Typhae pollen, stem or leaf of cattail Huang, hair wax, nature and flavor are sweet, micro-pungent, return through liver, the heart, spleen channel.Containing flavones ingredient as naringenin, isorhamnetin, Quercetin, isorhamnetin-3-O-rutinoside and typhaneoside, Quercetin-3-O-α-L-rhamnopyranosyl (1-2)-[α-L-rhamnopyranosyl (1-6)]-β-D-glucopyanoside.Tool stops blooding, blood stasis dispelling, treating stranguria effect.For spitting blood, epistaxis, spitting of blood, traumatic hemorrhage, gastral cavity ventral spine pain, tumbling and swelling, blood strangury and dry pain.
Radix Glycyrrhizae effect: Radix Glycyrrhizae is mainly containing compositions such as glycyrrhizic acid, glycyrrhizin, 24-hydroxyl enoxolone, licoflavone, glycyrrhizin, isoliquiritigenin, Angelica Polysaccharide.Glycyrrhizic acid is natural antidote, can be used for body defying age, enhancing immunity, maintenance water-electrolyte metabolism balance etc.There is effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, gastral cavity abdomen, cushion toxicity, strong.
The Chinese herbal medicine perfusate prescription foundation of this treatment cow endometritis: Chinese veterinarian claims cow endometritis to be band disease, many infection because of female animal antibacterial in puerperal, virus, or be not good at due to pregnancy period feeding and management, conceived burden is excessive, the factors such as excessive usage, childbirth cause QI and blood retardance or deficient, and then the positive deficiency of vital energy of body declines, pathogen is taken advantage of a weak point.Therapeutic Principle is blood circulation promoting and blood stasis dispelling normally, circulation of qi promoting of enriching blood.Therefore, prescription should with anti-inflammation, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, astringing to arrest bleeding, go erosion granulation promoting and enhancing human body immunity power for principle.Herba Houttuyniae, Herba Patriniae, Fructus Cnidii, Radix Sophorae Flavescentis anti-inflammation, heat clearing and damp drying, parasite killing in side.Herba Leonuri has promoting blood flow to regulate menstruation, the effect of the tissue regeneration promoting that gets rid of illness, and can strengthen strength of uterine contraction and contraction frequency, improves the tensile force of uterus muscle, accelerates involution of uterus process.Caulis Sargentodoxae, Fructus Liquidambaris, Radix Achyranthis Bidentatae, Herba Hyperici Japonici, Rhizoma Cyperi, Pollen Typhae can promoting blood circulation to restore menstrual flow, blood stasis dispelling, has the effects such as stronger blood circulation promoting, adjustment uterus function, dissipating blood stasis row are turbid, reducing swelling and alleviating pain.Fructus Cnidii, Radix Sophorae Flavescentis also have stronger osmosis, can promote that medicine accelerates diffusion in uterus, is evenly distributed, absorb to transmucosal, strengthen anti-inflammatory anti-itch effect, be conducive to the effect giving full play to intrauterine medicine.With Radix Glycyrrhizae sweet temperature QI invigorating and middle spleen invigorating, current twelve channels and collaterals, coordinating the actions of various ingredients in a prescription.In side all medicine phases and, play blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, anti-inflammation, the involution of uterus altogether, improve effect of immunity of organisms and resistance against diseases.Be applicable to the cow endometritis that a variety of causes causes.For convenience of using, make infusion liquid.
The Chinese herbal medicine perfusate of this treatment cow endometritis, on the basis of carrying out a large amount of practical application, according to traditional medicine ancient prescription, form in conjunction with modern popular disease, nosetiology and immunologic theory screening, be used for the treatment of cow endometritis, short treating period, cost be low, cure rate is high, safely, have no side effect, easy to use.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment:
1, difference weighting raw materials (herbal decoction piece) Herba Leonuri 175g, Herba Houttuyniae 150g, Herba Patriniae 100g, Fructus Cnidii 75g, Radix Sophorae Flavescentis 75g, Caulis Sargentodoxae 75g, Fructus Liquidambaris 75g, Radix Achyranthis Bidentatae 75g, Herba Hyperici Japonici 75, Rhizoma Cyperi 50g, Pollen Typhae 50g, Radix Glycyrrhizae 25g.
2, above-mentioned raw materials medicine is ground into Chinese herbal medicine coarse powder respectively;
3, by Herba Houttuyniae, Herba Patriniae, Radix Sophorae Flavescentis, Caulis Sargentodoxae, Fructus Liquidambaris, Radix Achyranthis Bidentatae, Herba Hyperici Japonici, Rhizoma Cyperi, the mixing of Chinese medicine of licorice root coarse powder, after the 7000mL that adds water soaks 1h, slow fire boiling 30min, put into Herba Leonuri, Fructus Cnidii, Pollen Typhae Chinese herbal medicine coarse powder again, slow fire boiling 30min, obtain boiling liquid for the first time, and then the 5000mL that at every turn adds water decocts secondary, each decoction 30min, obtains second time and boils liquid and boil liquid for the third time;
4, merge above-mentioned three times and boil liquid, filter, be concentrated into every milliliter of injection water containing crude drug 1g, obtain concentrating and boil liquid, then add the ethanol 1500mL that concentration is 95%, stir while adding, leave standstill 24h, go precipitation to get supernatant, boil off ethanol, be concentrated into every milliliter of injection water containing crude drug 2g, obtain concentrated medicament;
5, dripping dilute sodium hydroxide makes the pH of above-mentioned concentrated medicament reach 7.0, the active carbon adding this concentrated medicament weight 0.15% boils 30min, place 12h, filter, respectively add benzyl alcohol and the tween 80 of 1% by this concentrated medicament weight, stir evenly, No. G-3 vertical banyan glass funnel filters, and filtrate supplies 500mL with injection water, fill every bottle 10mL, 100 DEG C, 30min sterilizing, the i.e. Chinese herbal medicine perfusate of obtained this treatment cow endometritis.
Some tests utilizing the Chinese herbal medicine perfusate of this treatment cow endometritis to carry out are as follows:
1, this Chinese herbal medicine perfusate is to the drug sensitive test of cow endometritis the main pathogenic fungi
Choose clinical trouble endometritis milch cow case, through being separated, identifying, select pathogenic 2 kinds of stronger pathogen as staphylococcus aureus and streptococcus agalactiae.Take a certain amount of Chinese herbal medicine perfusate, 4 DEG C save backup.The staphylococcus aureus of clinical separation, streptococcus agalactiae are first inoculated in flat board, after cultivating 18h, select colonies typical and be inoculated in 5mL meat soup in 37 DEG C, after cultivating 18h in 37 DEG C, bacterium liquid, than turbid, is diluted to 10 with meat soup by 0.5 Maxwell unit norm opacity tube
6cFU/mL, for subsequent use.
Medicament sensitivity test adopts plate punch method, adds this Chinese herbal medicine perfusate of 1g/mL in hole, is not advisable outside overfolw hole to fill it up with.Separately get penicillin 10IU/ sheet, ampicillin 5 μ g/mL, ciprofloxacin 1 μ g/mL tri-kinds of antibiotic drug sensitive tests compare, be placed in 37 DEG C of constant incubators and cultivate 24h, measure antibacterial circle diameter, the drug sensitive test of often kind of medicine in triplicate.Criterion: according to " pharmacology of Chinese materia medica " standard with " U.S. clinical Laboratory Standard institute version in 2005 is about drug sensitive test standardization ", namely bacteriostatic diameter >=20mm is extremely quick, and 20mm> bacteriostatic diameter >=15mm is Gao Min; 15mm> bacteriostatic diameter >=10mm is quick in being, below 10mm is hypoallergenic.
This Chinese herbal medicine perfusate medicament sensitivity test the results are shown in Table 1.
This Chinese herbal medicine perfusate of table 1 is to the drug sensitive test result mm of two kinds of bacterium
| Medicine | Staphylococcus aureus | Streptococcus agalactiae |
| Penicillin | 20.0±1.5 | 19.5±0.5 |
| Ampicillin | 19.5±0.5 | 19.5±1.0 |
| Ciprofloxacin | 19.5±1.0 | 20.0±1.5 |
| This Chinese herbal medicine perfusate | 22.5±1.5 | 21.5±1.5 |
Table 1 shows, and to staphylococcus aureus, this Chinese herbal medicine perfusate is extremely quick, and bacteriostatic diameter reaches 22.5mm, and penicillin, ampicillin and ciprofloxacin are Gao Min; To streptococcus agalactiae, this Chinese herbal medicine perfusate is extremely quick, and bacteriostatic diameter reaches 21.5mm, and other medicines such as penicillin, ampicillin and ciprofloxacin are Gao Min.Drug sensitivity test shows, staphylococcus aureus and streptococcus agalactiae the most responsive to this Chinese herbal medicine perfusate; Ampicillin takes second place; The inhibitory action of this Chinese herbal medicine perfusate to staphylococcus aureus and streptococcus agalactiae is comparatively strong, and ampicillin takes second place.Comparatively the antibiotic such as penicillin is good to the inhibition of cow endometritis 2 kinds of pathogen for this Chinese herbal medicine perfusate, should as first-selection in the practice for the treatment of cow endometritis.
2. the safety testing of this Chinese herbal medicine perfusate
2.1 acute toxicity test
2.1.1 gavage method: 20 mices, are divided into 5 groups at random, often organize 4, male and female half and half.Each test group to mice respectively with 0.2mL/20g, 0.4mL/20g, 0.6mL/20g, 0.8mL/20g (1mL is equivalent to crude drug in whole 1g) gavage; Control group mice gavages distilled water with 0.8mL/20g.By experiment, this Chinese herbal medicine perfusate does not cause dead mouse by 0.8mL/20g to mouse stomach (1mL is equivalent to crude drug in whole 1g).Illustrate that the minimum dosis tolerata of mice to this Chinese herbal medicine perfusate is at more than 0.8g/20g.Test group compare with matched group mice spirit, had no abnormal changes by hair, behavior, appetite etc.
2.1.2 intraperitoneal injection: pilot study 6 mices are divided into 3 groups, male and female half and half.Lumbar injection said preparation, obtains the maximal dose 0.2mL/20g making mouse survival according to mouse survival number, obtain the minimum dose 1.0mL/20g (1mL is equivalent to crude drug in whole 1g) making mice all dead according to dead mouse number.Formal test 30 mices are divided into 6 groups at random, often organize 5.According to pilot study result, if 5 dosage groups: 10.0g/kg, 15.0g/kg, 22.5g/kg, 33.8g/kg, 50.6g/kg (between dosage group, agent distance is than being no more than 1.5), 1 matched group: intraperitoneal injection of saline 1.0mL/20g.Mice performance rapid breathing after medication, palpitating speed, exophthalmos, is erect by hair, hogback, and whole body is micro-to be trembled, and tail is crispaturaed, and sufficient pawl shrinks, low position walking, and then postural reflex disappears, and upper and lower catacleisis also has discharge of eye, and respiratory frequency slows down, then dead.Cut open inspection and see heart congestion, other organ no abnormality seen.By formula: Log LD50=Xm-d (∑ p-0.5), can try to achieve this Chinese herbal medicine perfusate to the LD50 of mice is 0.6942g/20g (LD50 is 34710mg/kg).According to medicinesafety evaluation criterion, belong to actual nontoxic as LD50>5000mg/kg, this Chinese herbal medicine perfusate is 34710mg/kg>5000mg/kg to the LD50 of mice, illustrates nontoxic.
2.2 rabbit eyes irritation tests: adopt consubstantiality own control.Get healthy rabbits 4, check two of every rabbit, normal person can be used for test.Pull open palpebra inferior gently, after eyeball, this Chinese herbal medicine perfusate and each 0.1mL of normal saline are instilled in the right and left eyes conjunctival sac of rabbit respectively, two infusion volumes are equal, then eyelid of gently sleeping is about 1s-2s, in order to avoid medicinal liquid and normal saline flow out, affects result of the test.When observing 1h, 6h, 12h, 24h and 36h after administration, eye conjunctiva is with or without hyperemia, edema, photophobia and the irritant reaction such as to shed tears.
By the contrast to the medication of 4 rabbit right and left eyes and normal saline, have after result display medication 1h and slightly shed tears and congested phenomenon, stopping of shedding tears after 12h, congested phenomenon is more obvious, and after 24h, congested phenomenon weakens gradually, and the congested phenomenon of 36h disappears.Result of the test shows that this Chinese herbal medicine perfusate is to mucosa nonirritant.
The detection of hematological indices before and after the medication of 2.3 Chinese herbal medicine perfusate treatment cow endometritis: clinical definite is the case 10 (Chinese herbal medicine perfusate treatment) of cow uteri film inflammation, normal healthy controls group milch cow 8 same period (non-medication treatment), ill matched group milch cow 10 (non-medication treatment).This Chinese herbal medicine perfusate treatment group milch cow is treated making a definite diagnosis ill this Chinese herbal medicine perfusate rear, and dosage 400mL-500mL, waits warm uterine perfusion, every day 1 time, and 3d was 1 course for the treatment of.This Chinese herbal medicine perfusate treatment group milch cow respectively after making a definite diagnosis before medication and cure after each jugular vein blood collection once, carry out red blood cell count(RBC), numeration of leukocyte, content of hemoglobin, differential blood count etc.Healthy cow matched group and the blood sampling same period of ill milch cow matched group, carry out red blood cell count(RBC), numeration of leukocyte, content of hemoglobin, differential blood count equally.In blood, the measurement result of RBC number, hemoglobin content and packed cell volume is in table 2, and blood middle leukocytes sum and differential blood count the results are shown in Table 3.
The measurement result unit of RBC number, hemoglobin content and packed cell volume: ten thousand/mm in table 2 blood
3, gram/ml, %
Table 3 blood middle leukocytes sum and differential blood count result unit: ten thousand/mm
3, %
As can be seen from Table 2, puerperal, cow blood RBC number, content of hemoglobin, the packed cell volume of health maintained normal level substantially, the RBC number of trouble endometritis milch cow, content of hemoglobin, packed cell volume are less, the RBC number of this Chinese herbal medicine perfusate treatment group milch cow milch cow after medication is cured, content of hemoglobin, packed cell volume maintain normal level, illustrate that this Chinese herbal medicine perfusate can increase erythrocyte, content of hemoglobin, the packed cell volume quantity of milch cow.Erythrocyte and hemoglobin play an important role in body hemopoietic and oxygen transportation, very important to animal survival, growth and production, and erythrocyte also has partial immunity function.After the endometritis of this Chinese herbal medicine perfusate treatment milch cow, these three indexs significantly increase, and reach normal value, illustrate that this Chinese herbal medicine perfusate has the effect increasing RBC number in blood and content of hemoglobin.
As can be seen from Table 3, suffer from the total white blood cells in endometritis cow blood, neutrophilic granulocyte number, mononuclear cell is significantly higher than the healthy cow same period, after the treatment of this Chinese herbal medicine perfusate, total white blood cells, neutrophilic granulocyte number, mononuclear cell significantly declines, and the total white blood cells of the ill milch cow treated without this Chinese herbal medicine perfusate, neutrophilic granulocyte number, mononuclear cell maintains higher level all the time, higher than normal healthy controls group, illustrate that this Chinese herbal medicine perfusate can reduce the total white blood cells of suffering from endometritis cow blood, neutrophilic granulocyte number, mononuclear cell, make it to recover normal level, the percentage of lymphocyte suffering from endometritis milch cow is more on the low side than the healthy cow same period, after the treatment of this Chinese herbal medicine perfusate, this ratio rises fast, milch cow after healing this indicator difference compared with healthy cow is not remarkable, shows that this Chinese herbal medicine perfusate can improve the percentage of lymphocyte suffered from endometritis cow blood leukocyte.Leukocyte is the important immunocyte of body, and only have when body is in the infection defence phase, this cell just can be bred in a large number, neutrophilic granulocyte is the most common in the suppurative infection phase, and now, this cell is discharged into peripheral blood from hemopoietic organ, and disengage from microcirculatory vascular, infiltrate in areas of inflammation.This cell has active motor capacity and phagocytic function; but the life-span is shorter; become pus cell after death, this is also that endometritis is often converted into one of reason of chronic purulence endometritis, and neutrophilic granulocyte increases the evolution of also having pointed out local inflammation in milch cow body.In test, the neutrophilic granulocyte of this Chinese herbal medicine perfusate treatment group milch cow significantly declines, and is also just reflecting that this Chinese herbal medicine perfusate has played good effect, is eliminating the proinflammatory factors in body, just making the ratio of neutrophilic granulocyte return to normal level.Lymphocyte is also important immunologically competent cell, do not possess phagocytic function, antibody materials in main generation body, when there is viral infection, in body, quantity significantly rises, when Abwehrkraft des Koepers decline or immunologic hypofunction, the ratio regular meeting of this cell declines, the percentage of lymphocyte suffering from endometritis milch cow in this test significantly declines, also the hypoimmunity of these milch cows due to self is reflected, cause some conditioned pathogen amount reproductions of intrauterine and cause cow endometritis, this Chinese herbal medicine perfusate have adjusted the total defense function of animal body just, the autoimmunity of ill milch cow is improved, lymphocytic ratio just rises to normal level.Under normal circumstances, mononuclear cell exists in the middle of blood, but negligible amounts.When body local is inflamed, due to inflammatory stimulus, this cell is bred in a large number, and by blood circulation, arrive areas of inflammation, play phagocytic function, it often comes across the inflammation later stage, chronic inflammation processes etc.This result of the test shows, this Chinese herbal medicine perfusate can make mononuclear cell ratio increase, and the symptom of endometritis is alleviated, and illustrates that body is repaired the endometrium of inflammatory destruction.
Above experimental result shows, the Chinese herbal medicine perfusate of this treatment cow endometritis has anti-inflammation, adjusts uterus function, improves local blood circulation, adjustment intrauterine environment, increase medicine and in uterus spread, permeate and the feature such as Absorption, nonirritant, raising immunity.
Claims (2)
1. treat a Chinese herbal medicine perfusate for cow endometritis, it is characterized in that it is made up of the crude drug of following weight parts: Herba Leonuri 5 parts-7 parts, Herba Houttuyniae 4 parts-6 parts, Herba Patriniae 2 parts-4 parts, Fructus Cnidii 2 parts-4 parts, Radix Sophorae Flavescentis 2 parts-4 parts, Caulis Sargentodoxae 2 parts-4 parts, Fructus Liquidambaris 2 parts-4 parts, Radix Achyranthis Bidentatae 1 part-3 parts, Herba Hyperici Japonici 1 part-3 parts, Rhizoma Cyperi 1 part-2 parts, Pollen Typhae 1 part-2 parts, 1 part-2 parts, Radix Glycyrrhizae.
2. the Chinese herbal medicine perfusate for the treatment of cow endometritis according to claim 1, is characterized in that it is made up of the crude drug of following weight parts: Herba Leonuri 7 parts, Herba Houttuyniae 6 parts, Herba Patriniae 4 parts, Fructus Cnidii 3 parts, Radix Sophorae Flavescentis 3 parts, Caulis Sargentodoxae 3 parts, Fructus Liquidambaris 3 parts, Radix Achyranthis Bidentatae 3 parts, Herba Hyperici Japonici 3 parts, Rhizoma Cyperi 2 parts, Pollen Typhae 2 parts, 1 part, Radix Glycyrrhizae.
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| CN104958704A (en) * | 2015-07-17 | 2015-10-07 | 胡洪杰 | Pharmaceutical composition for treating bovine endometritis and preparation method of pharmaceutical composition |
| RU2617538C1 (en) * | 2016-02-19 | 2017-04-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Донской государственный аграрный университет" | Means for farm animals postpartum endometritis treatment and prevention |
| CN105726681A (en) * | 2016-04-28 | 2016-07-06 | 青岛海之星生物科技有限公司 | Injection for treating dairy cattle endometritis and preparing method of injection |
| CN106177447A (en) * | 2016-09-09 | 2016-12-07 | 马玉珍 | A kind of treat the cow uteri the most complete Chinese medicine composition of retraction |
| CN107714850A (en) * | 2017-10-18 | 2018-02-23 | 河南永辉生物科技股份有限公司 | For sow midwifery, the palace of the Qing Dynasty, progestogenic Chinese prescription perfusion liquid |
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| CN113144006A (en) * | 2021-04-27 | 2021-07-23 | 湖南美可达生物资源股份有限公司 | Traditional Chinese medicine composition for treating endometritis of female animals and preparation method and application thereof |
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