CN104510668A - Moisture retention composition, preparation method and application thereof - Google Patents
Moisture retention composition, preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a moisture retention composition, a preparation method and application thereof. The moisture retention composition includes moisture retention active ingredients, which at least include Prinsepia utilis Royle oil and Prinsepia utilis Royle polysaccharide in a weight ratio of 0.5-10:1. According to the invention, the Prinsepia utilis Royle oil and Prinsepia utilis Royle polysaccharide are compounded in a specific proportion to reach a synergistic effect. When other conditions are the same, the combination of the two has a better moisture retention effect than any one of the two. With good moisture retention efficacy, the moisture retention composition provided by the invention is suitable for application in cosmetics, health products and medicines, especially can be used in cosmetics, and can be added at different dosages according to different types of preparations.
Description
Technical field
The present invention relates to moisture-keeping composition and preparation method thereof.
Background technology
The barrier function of skin care interior tissue depends on the hydration moisture-retaining capacity of skin, and the moisture storage capacity of skin accounts for the 18%-20% of whole body.The variations in temperature that air-conditioning, environmental pollution, Seasonal conversion bring and pressure, and skin aging, metabolism the factor such as to slow down skin excessive water all can be caused to run off, make skin coarse, dim mute, form dry stricture of vagina, cause many skin problems.Prevent moisture of skin excessively to run off, for the health keeping good skin barrier function and skin, and even the outward appearance of skin beauty is very important.
In order to reach maintenance moisture of skin, reducing the object that excessive water scatters and disappears, usually in skin preparations for extenal use, adding moisturizing ingredient.Wetting agent kind is a lot, and conventional moisturizing ingredient can be divided into enclosed type wetting agent and the large class of hygroscopicity wetting agent two.The effect of enclosed type wetting agent is by forming rete at skin surface, stop moisture of skin evaporation, thus make the water content that horny layer keeps certain, this class wetting agent comprises mineral oil and wax as vaseline, vegetable oil and Animal fat as lanoline, phospholipid, cholesterol etc.Hygroscopicity wetting agent is that a class is similar to nature moisturizing factor in epidermis, can combine with water brute force and reach the effect making horny layer moisturizing.This type of moisturizing ingredient has: nature moisturizing factor, protein, polysaccharide, ceramide, various vitamin etc.The wetting agent of animal and mineral origin easily causes the problem such as skin allergy, skin irritation, finds natural moisture preserving agent and meet people to the demand coming from natural cosmetics from plant.
Blue or green thorn is Rosaceae Prinsepia Royle plant Folium Prinsepiae Utilis Prinsepia utilis, has another name called buy oil fruit, Passiflora edulis sims etc.Blue or green thorn produces Yunnan, Guizhou, Sichuan, Tibet.Be born in the places such as hillside, wasteland, mountain valley or roadside, height above sea level 1000-2560 rice.Pakistan, Nepal, Bhutan and north India also have distribution.Blue or green thorn stem, leaf, really, root all can be used as medicine, and taste is micro-pungent, has the effect such as blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, treatment gunshot wound.Blue or green thorn seed is rich in oils and fats, general oil yield about 30%.
Traditionally, Princepia utilis is in the application of existing more than one thousand years among the people.Princepia utilis oil spreads upon on skin, and the lump that can prevent mosquito bite or elimination osteopatia sprain from being formed, prevents chapped skin, pruritus and healing chilblain; Send out can suppress alopecia by Princepia utilis oil rubbing head, have the effect making poliosis blackening; Human body skin localized burn and scald, be applied to affected part with Princepia utilis oil and can prevent wound infection, accelerating wound and preventing from scar.Among the people in locality, smear the skin of ewborn infant with Princepia utilis oil, make the dry and comfortable lubrication of skin, and coming off of baby lanugo can be promoted.According to patent retrieval, the application of current Princepia utilis in cosmetics is all object of study with Princepia utilis oil.In the products application in modern times, also mostly apply Princepia utilis oil, and develop its moisturizing, the effect such as crease-resistant.
Summary of the invention
Technical problem to be solved by this invention is to provide one and has synergistic function, the moisture-keeping composition of moistening effect excellence.
The present invention relates to application and the preparation method of above-mentioned composition simultaneously.
For solving above technical problem, a kind of technical scheme that the present invention takes is:
A kind of moisture-keeping composition, comprise moisturizing active component, particularly, this moisturizing active component at least comprises Princepia utilis oil and Princepia utilis polysaccharide, and the weight ratio of Princepia utilis oil and Princepia utilis polysaccharide is 0.5 ~ 10:1.
Preferably, the weight ratio of Princepia utilis oil and Princepia utilis polysaccharide is 0.5 ~ 6:1.More preferably, the weight ratio of Princepia utilis oil and Princepia utilis polysaccharide is 2 ~ 6:1, and most preferably, the weight ratio of Princepia utilis oil and Princepia utilis polysaccharide is 1 ~ 3:1.
Moisture-keeping composition of the present invention has good effect in moisturizing, is suitable for applying in cosmetics, health product and medicine, especially can be applicable in cosmetics, the consumption different according to the dissimilar interpolation of preparation.
The present invention is also in particular to a kind of external skin moisturizer, and it contains the above-mentioned moisture-keeping composition of the present invention.
General, the mass content that described moisturizing active component accounts for described external skin moisturizer is 1 ~ 20%.Preferably, moisturizing active component accounts for the mass content of external skin moisturizer is 5 ~ 15%.
According to the present invention, bur oil, Princepia utilis polysaccharide can adopt conventional means known in this field to prepare, also can be commercially available.
The another technical scheme that the present invention takes is: a kind of preparation method of above-mentioned moisture-keeping composition, and it comprises the following steps:
(1) with Princepia utilis seed for raw material, obtain Princepia utilis oil and oil meal through solvent impregnated extraction, by remain in oil meal solvent removing, stand-by;
(2) step (1) gained oil meal is boiled in boiling water, boil rear elimination bits, retain filtrate, after filtrate is concentrated, add trichloroacetic acid, deproteinization at 0 ~ 10 DEG C, centrifugal, supernatant adds alkali neutralization, and flowing water is dialysed, concentrated, adding ethanol again makes system ethanol mass content be 75% ~ 85%, precipitates and obtains bur polysaccharide through lyophilization.
Concrete and the preferred aspect according to one, in step (1), described solvent is petroleum ether, step (1) is specifically implemented as follows: get Princepia utilis seed, dry, and pulverizes, extract three times by petroleum ether soaking at room temperature, soak 6 ~ 8 days, after having soaked at every turn, petroleum ether extract vacuum concentration, reclaim petroleum ether, obtain Princepia utilis oil, the oil meal after Petroleum ether extraction, volatilization removes residual petroleum ether completely, stand-by.
According to another concrete and preferred aspect, in step (2), described deproteinization is carried out at 0 ~ 5 DEG C, described dialysis time is 30 ~ 60 hours, described in the ethanol that adds be the ethanol of volumn concentration 95%.
According to the present invention, in moisture-keeping composition, moisturizing active component can also comprise other active component one or more of.Other active component can be such as pantothenylol, glycyrrhizic acid dipotassium, allantoin, nicotiamide, NAP, Herba Violae Hortensis extract, hyaluronate sodium, tocopherol acetas, undecylenoyl phenylalanine etc.In addition, this type of describes is for the ease of understanding, and is not the application or listed application that composition are limited to specifically note.
According to the present invention, described skin preparations for extenal use is the general designation concept of all the components being generally used for skin outside, such as, can be cosmetic combination or pharmaceutical compositions.Can be foundation make up material, facial dressing cosmetic preparation, health cosmetic preparation, hair nursing cosmetic preparation etc. in described cosmetic combination, to its dosage form without particular restriction, can choose reasonable according to different object.
According to the medium difference also allowed containing different cosmeceutical aspects of dosage form and object or matrix excipients in described cosmetic combination.
May be used for the cosmetics of skin preparations for extenal use of the present invention, dermatological or pharmaceutically acceptable excipient can be the form of aqueous phase, oil phase, gel, water bag wax pattern emulsion, emulsion oil-in-water or water-in-oil emulsion.Aqueous phase is the mixture of one or more water solublity or dispersibility component, and it can be at room temperature liquid, semisolid or solid.It can be maybe the form of suspension, dispersion liquid or the solution in water or water-ol excipient that excipient comprises, and it can contain thickening agent or gel.The product form that the knowledge-chosen that those skilled in the art can grasp based on those skilled in the art is suitable and the component wherein comprised.
Described cosmetic combination can comprise aqueous phase, this aqueous phase can contain the mixture of water or water and at least one hydrophilic organic solvent, described hydrophilic organic solvent such as alcohol, the straight or branched low-grade monobasic alcohol especially containing 2-5 carbon atom, as ethanol or propanol; Polyhydric alcohol, as propylene glycol, sorbitol, glycerol, pantothenylol or Polyethylene Glycol and composition thereof.
When cosmetic combination is emulsion form, said composition optionally can also comprise surfactant.
Described cosmetic combination can also comprise film forming polymer, as polyurethanes, polyacrylic acid homopolymer or copolymer, polyester, based on the resin of hydrocarbon and/or silicone resin.Polymer can be dissolved in or to be scattered in the acceptable excipient of cosmetics and optional and plasticizer merges.
Cosmetic combination of the present invention can also comprise oil phase, and described oil phase contains at room temperature for the oil-soluble of liquid or oil-dispersing property component and/or be at room temperature oily or wax-like material, as wax, semisolid, natural gum and composition thereof.This oil phase can also contain organic solvent.
Usually be at room temperature liquid, suitable oily matter comprises: the oil based on hydrocarbon deriving from animal, as perhydro-squalene; Based on the vegetable oil of hydrocarbon, as the triglyceride of the C4-10 fatty acid of liquid, such as enanthic acid or Trivent OCG class, or oil, such as Oleum helianthi, Semen Maydis oil, soybean oil, Oleum Vitis viniferae, Oleum Ricini, American Avocado Tree oil, caprylic/capric triglyceride class, Jojoba oil; The straight or branched hydro carbons in mineral or synthesis source, such as liquid paraffin and its derivant, vaseline; The esters of synthesizing ester and ethers, particularly fatty alcohol, such as isopropyl myristate, Palmic acid 2-Octyl Nitrite, stearic acid 2-octyldodecyl, isostearyl isostearate ester; Hydroxylating esters, the enanthic acid esters of such as lactic acid isooctadecanol ester, octyl hydroxystearate, octyl hydroxystearate, hydroxy stearic acid octyldodecyl, fatty alcohol, sad esters and capric acid lipid; Polyhydric alcohol esters, such as propylene, neopentyl glycol two heptanoate, the different pelargonate of diethylene glycol two and pentaerythritol esters; Aliphatic alcohols containing C 12-26, such as octyldodecanol, 2-butyl capryl alcohol, 2-hexyldecanol, 2-undecylpentadecanol, oleyl alcohol; Based on fluorocarbon oil and/or the fluorosilicon oil of part hydrocarbon, silicone oil, be at room temperature liquid or semisolid volatility or nonvolatile straight chain or cyclo-methicone, such as annular dimethyl polysiloxane and polydimethylsiloxane, it optionally comprises phenyl, such as Silicone DC 556, siloxanes and composition thereof.
Cosmetic combination of the present invention can comprise any component be usually used in cosmetic field further.These components comprise antiseptic, water phase thickener (polysaccharide biopolymer, synthetic polymer) and fatty phase thickening agent, aromatic, hydrophilic and lipophilic active agent and composition thereof.
Compositions of the present invention can be mixed with any suitable product form.This kind of product form includes, but are not limited to aerosol spray, cream, emulsion, solid, liquid, dispersion, foam, gel, astringent, mousse, ointment, powder, patch, brilliantine, solution, hands by pump-type spray, club, facial film and wet paper towel.Can using compositions of the present invention by various method well-known in the art expediently for the preparation of or as cosmetics, dermatological or medicine local application product.
Skin preparations for extenal use of the present invention can comprise one or more following ingredients: anti-allergic agent, antimicrobial, antioxidant, chelating agen, coloring agent depigmentation, emollient, emulsifying agent, exfoliation agent, film former, spice, wetting agent, insect repellent, lubricant, pharmaceutically active agents, humidizer, photostabilizer, antiseptic, skin protectant, skin penetration enhancer, sunscreen, stabilizing agent, surfactant, thickening agent, viscosity modifier, vitamin or its combination in any.
Due to the employing of above technical scheme, the present invention compared with prior art has following advantage:
The present invention by Princepia utilis oil and Princepia utilis polysaccharide composite in specific proportions, have synergistic function, when other conditions are identical, wherein any one all has better moistening effect than using for the combination of both uses.
Detailed description of the invention
Below to be described in further details the present invention in conjunction with specific embodiments.Should be understood that these embodiments are for illustration of ultimate principle of the present invention, principal character and advantage, and the present invention is not limited by the following examples.The implementation condition adopted in embodiment can do further adjustment according to specific requirement, and not marked implementation condition is generally the condition in normal experiment.Embodiment is raw materials used is industrial goods.
Embodiment 1: the extraction of Princepia utilis oil
In the present invention, the extraction of Princepia utilis oil adopts the mode of low-temperature extraction, reduces the loss of unsaturated fatty acid in Princepia utilis oil as far as possible.Get Princepia utilis seed, dry, pulverize.Three times are extracted, each immersion 7 days by petroleum ether soaking at room temperature.After immersion completes, petroleum ether extract vacuum concentration, reclaims petroleum ether, obtains Princepia utilis oil.Oil meal after Petroleum ether extraction, volatilization removes residual petroleum ether, completely as the extraction of next step Princepia utilis polysaccharide.
Embodiment 2: prepared by Princepia utilis polysaccharide
Get Princepia utilis oil meal and be about 30g, add 300ml boiling water boiling 3 times, each filtrate is merged, be concentrated into about 300ml, add trichloroacetic acid deproteinization at 4 DEG C; Centrifugal, supernatant NaOH neutralizes, flowing water dialysis 2d; Be concentrated into about 150ml, add 95% ethanol and make system alcohol content reach 75%; Pellet frozen is dry obtains Princepia utilis polysaccharide-1.
Embodiment 3: prepared by Princepia utilis polysaccharide
After getting Princepia utilis alcohol extraction, residue is about 30g, adds 300ml boiling water boiling 3 times, each filtrate is merged, be concentrated into about 300ml, adds trichloroacetic acid deproteinization at 4 DEG C; Centrifugal, supernatant NaOH neutralizes, flowing water dialysis 2d; Be concentrated into about 150ml, add 95% ethanol and make system alcohol content reach 80%; Pellet frozen is dry obtains Princepia utilis polysaccharide-2.
Embodiment 4: prepared by Princepia utilis polysaccharide
Get Princepia utilis oil meal and be about 30g, add 300ml boiling water boiling 3 times, each filtrate is merged, be concentrated into about 300ml, add trichloroacetic acid deproteinization at 4 DEG C; Centrifugal, supernatant NaOH neutralizes, flowing water dialysis 2d; Be concentrated into about 150ml, add 95% ethanol and make system alcohol content reach 85%; Pellet frozen is dry obtains Princepia utilis polysaccharide-3.
Embodiment 5: sugared assay
Adopt sulfuric acid-phynol method, by spectrophotometric determination 490nm place trap after colour developing, take glucose as contrast, drawing standard curve, calculates sugared content in Princepia utilis polysaccharide.
1., production standard curve: accurately take dextran standards (or glucose) 20mg in 500ml volumetric flask, add water to scale, draw 0.4,0.6,0.8,1.0,1.2,1.4,1.6 and 1.8ml respectively, respectively mend to 2.0ml with distilled water, then 6% phenol 1.0ml and concentrated sulphuric acid 5.0ml is added, shake up cooling, room temperature is placed after 20 minutes in 490nm densitometric, same color operation is pressed for blank with 2.0ml water, abscissa is polysaccharide micrograms, vertical coordinate is optical density value, obtains standard curve.
2., sample thief 1 gram add 1ml 15%TCA solution grinding, then add a little 5%TCA solution grinding, fall supernatant in 10 milliliters of centrifuge tubes, then add a little 5%TCA solution grinding, fall supernatant, repeat 3 times.For the last time residue one is played into centrifuge tube.Attention: total solution does not exceed 10 milliliters.
3., centrifugal, rotating speed 3000 revs/min, totally three times.15 minutes first times, get supernatant.Within latter twice each 5 minutes, get supernatant in 25 milliliters of taper ratio colour tubes.Last filtrate keeps about 18 milliliters.
4., water-bath, shake up after add 2 milliliters of 6mol/L hydrochloric acid in color comparison tube, water-bath 2 hours in 96 DEG C of water-baths.
5., constant volume samapling.After water-bath, shake up with adding 2 milliliters of 6mol/L sodium hydroxide after flowing water cooling.Be settled in the volumetric flask of 25 milliliters.Draw the sample liquid of 0.2ml, mend to 2.0ml to distill, then add 6% phenol 1.0ml and concentrated sulphuric acid 5.0ml, shake up cooling room temperature and place after 20 minutes in 490nm densitometric.Each mensuration gets two sample contrast.Polyoses content is calculated with standard curve.
6., result: regression equation is Y=7.4898X-0.00442, R2=0.9996 as calculated, and glucosan concentration is good linear with absorbance within the scope of 0 ~ 105.0 μ g/mL.Be measured in the same method sample absorbance, calculating total sugar content in Princepia utilis polysaccharide-1 is 33.85%, and in Princepia utilis polysaccharide-2, total sugar content is 40.38%, and in Princepia utilis polysaccharide-3, total sugar content is 38.67%.
Embodiment 6: containing the emollient cream of Princepia utilis oil and Princepia utilis polysaccharide
Conventionally, the Princepia utilis oil of different proportion and the emollient cream of Princepia utilis polysaccharide is comprised according to the preparation of table 1 formula:
Table 1
Embodiment 7: the moisture-keeping functions evaluation of the emollient cream of embodiment 6
When often kind of compositions uses one time, in order to the skin moistening performance of a specified duration of test composition, the face of the complaint xerosis cutis several cosmetic compositions in embodiment 6 being applied to 30 30-40 years or the men and women be sure oing to have dry skin and inner forearm.After 24 hours, moisture of skin tester (CM820ourage Khazakaelectronic GmbH, Germany) is used to measure the skin moisture content of each experimenter.Before using beginning, use moisture of skin tester under the condition of steady temperature and constant humidity (24 DEG C and 40% humidity), measure the skin moisture content of each experimenter, and as with reference to value, to measure after using at once and the change of the skin moisture content of using latter 2 hours, 4 hours and 8 hours.Measurement result is shown in following table 2.
Use the assay method of moisture of skin tester
Principle: determine performance of keeping humidity by the water ion degree using sensor to measure in epiderm skin, with numeric representation measurement result, and calculate moisture.
1) probe of moisture of skin tester is placed in skin part to be measured.
2) when probe extruding skin, the electric capacity of skin will be presented on screen by sensor with numerical value.
3), after once measuring, use dust-free paper wiping sensor, then carry out the mensuration at another position.
Table 2
According to test result, the emollient cream containing different proportion Princepia utilis oil and Princepia utilis polysaccharide all has good skin moisturization.Simultaneously, when adding total amount and being identical, sample containing Princepia utilis oil and Princepia utilis polysaccharide has better moistening effect, especially permanent moistening effect is more remarkable, and the formula 3 such as containing Princepia utilis oil and Princepia utilis polysaccharide, formula 4, formula 5 have than formula 1 (only containing Princepia utilis polysaccharide) and the more lasting moistening effect of formula 2 (only containing Princepia utilis oil).Its reason may be that the formula containing Princepia utilis composite extract all has contribution in enclosed type moisturizing and hygroscopicity moisturizing two.
Above to invention has been detailed description; its object is to allow the personage being familiar with this art can understand content of the present invention and be implemented; can not limit the scope of the invention with this; the equivalence change that all spirit according to the present invention are done or modification, all should be encompassed in protection scope of the present invention.
Claims (10)
1. a moisture-keeping composition, comprises moisturizing active component, it is characterized in that: described moisturizing active component at least comprises Princepia utilis oil and Princepia utilis polysaccharide, and the weight ratio of described Princepia utilis oil and Princepia utilis polysaccharide is 0.5 ~ 10:1.
2. moisture-keeping composition according to claim 1, is characterized in that: the weight ratio of described Princepia utilis oil and Princepia utilis polysaccharide is 0.5 ~ 6:1.
3. moisture-keeping composition according to claim 2, is characterized in that: the weight ratio of described Princepia utilis oil and Princepia utilis polysaccharide is 1 ~ 3:1.
4. the application of moisture-keeping composition in cosmetics, health product and medicine according to claim 1 or 2 or 3.
5. an external skin moisturizer, is characterized in that: containing the moisture-keeping composition described in claim 1 or 2 or 3.
6. external skin moisturizer according to claim 5, is characterized in that: the mass content that described moisturizing active component accounts for described external skin moisturizer is 1 ~ 20%.
7. external skin moisturizer according to claim 6, is characterized in that: the mass content that described moisturizing active component accounts for described external skin moisturizer is 5 ~ 15%.
8. a preparation method for claim 1 or the moisture-keeping composition described in 2 or 3, is characterized in that comprising the following steps:
(1) with Princepia utilis seed for raw material, obtain Princepia utilis oil and oil meal through solvent impregnated extraction, by remain in oil meal solvent removing, stand-by;
(2) step (1) gained oil meal is boiled in boiling water, boil rear elimination bits, retain filtrate, after filtrate is concentrated, add trichloroacetic acid, deproteinization at 0 ~ 10 DEG C, centrifugal, supernatant adds alkali neutralization, and flowing water is dialysed, concentrated, adding ethanol again makes system ethanol mass content be 75% ~ 85%, precipitates and obtains Princepia utilis polysaccharide through lyophilization.
9. preparation method according to claim 8, is characterized in that: in step (1), and described solvent is petroleum ether, step (1) is specifically implemented as follows: get Princepia utilis seed, dry, and pulverizes, extract three times by petroleum ether soaking at room temperature, soak 6 ~ 8 days, after having soaked at every turn, petroleum ether extract vacuum concentration, reclaim petroleum ether, obtain Princepia utilis oil, the oil meal after Petroleum ether extraction, volatilization removes residual petroleum ether completely, stand-by.
10. preparation method according to claim 8, is characterized in that: in step (2), and described deproteinization is carried out at 0 ~ 5 DEG C, and described dialysis time is 30 ~ 60 hours, described in the ethanol that adds be the ethanol of volumn concentration 95%.
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CN109364132A (en) * | 2018-12-20 | 2019-02-22 | 文山合丰生物科技有限公司 | The extracting method of effective component and green bur extract gel in tattoo fruit |
CN109700909A (en) * | 2019-03-19 | 2019-05-03 | 孟召阳 | A kind of preparation method of quick-acting plaster |
CN114699355A (en) * | 2022-06-07 | 2022-07-05 | 云南英格生物技术有限公司 | Nucleus pulposus anti-allergy composition and preparation method and application thereof |
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Cited By (8)
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CN105919842A (en) * | 2016-03-29 | 2016-09-07 | 高小娜 | Prinsepiautilisroyle body cleaner |
CN106691942A (en) * | 2017-01-24 | 2017-05-24 | 广州市科能化妆品科研有限公司 | Sun-screening and repairing cosmetic composition as well as preparation method and application thereof |
CN106691942B (en) * | 2017-01-24 | 2021-04-02 | 广州市科能化妆品科研有限公司 | Sunscreen repair cosmetic composition and preparation method and application thereof |
CN109260057A (en) * | 2018-11-08 | 2019-01-25 | 妃瑶生物科技(上海)有限公司 | A kind of extracting method of prinsepia utilis royle oil composition |
CN109364132A (en) * | 2018-12-20 | 2019-02-22 | 文山合丰生物科技有限公司 | The extracting method of effective component and green bur extract gel in tattoo fruit |
CN109364132B (en) * | 2018-12-20 | 2021-04-27 | 文山合丰生物科技有限公司 | Method for extracting effective components from prinsepia utilis royle |
CN109700909A (en) * | 2019-03-19 | 2019-05-03 | 孟召阳 | A kind of preparation method of quick-acting plaster |
CN114699355A (en) * | 2022-06-07 | 2022-07-05 | 云南英格生物技术有限公司 | Nucleus pulposus anti-allergy composition and preparation method and application thereof |
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