CN104491629A - External traditional Chinese medicinal composition for treating perianal eczema, and preparation method thereof - Google Patents
External traditional Chinese medicinal composition for treating perianal eczema, and preparation method thereof Download PDFInfo
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- CN104491629A CN104491629A CN201410691287.7A CN201410691287A CN104491629A CN 104491629 A CN104491629 A CN 104491629A CN 201410691287 A CN201410691287 A CN 201410691287A CN 104491629 A CN104491629 A CN 104491629A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
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- Microbiology (AREA)
- Medical Informatics (AREA)
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- Biotechnology (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an external traditional Chinese medicinal composition for treating perianal eczema, and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicinal composition comprises Pericarpium Zanthoxyli, Fructus Cnidii, Sophora flavescens, Radix Stemonae, Amur Corktree Bark, Artemisia argyi, mirabilite, Chinese gall, alum and honeysuckle flower. Clinically acceptable various external dosage forms can be prepared by directly or indirectly adding a pharmaceutically acceptable excipient to the traditional Chinese medicinal composition through a routine preparation production technology. The external traditional Chinese medicinal composition can safely and effectively treat perianal eczema, has the advantages of definite method and therapeutic effect, low recurrence rate, low price and easy wide popularization, and is especially suitable for wide development and popularization in basic hospitals.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of external medicine composition for the treatment of anal eczema and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Anal eczema is a kind of anus allergic disease caused by multiple internal and external factor, major lesions position is at the superficial dermis of skin of anus and epidermis, local skin acute pruritus, it is that limitation infiltrates plump that skin lesion shows as anus edge skin, rough surface, can chap and lichenification, recurrent exerbation.The anal eczema cause of disease and anus local patholoic change, the factor such as stimulation and chronic infection, endocrine, neural factors, diet, environment, heredity as the disease such as hemorrhoid, anal fistula is relevant.Initial stage mostly is erythra, and merocrine secretion's thing increases, and take pruritus as feature, and pachyderma of with the passing of time scratching is coarse, becomes and lichenification in eczema sample, companion's desquamation, incrustation and scratch etc., also have at the beginning chronic person.
Anal eczema is divided into acute eczema and chronic eczema, acute eczema: any position acute eczema generally all follows flushing-pimple (maculopapule)-vesicle (oozing out)-erosion-incrustation (squama)-pigment this process newborn, occur together pruritus simultaneously, clinical outstanding behaviours is that serosity oozes out obviously, strict person is oozed out in a drop-wise, violent pruritus makes trials and tribulations with tolerance, scratch is there is owing to scratching, blood crusts, merge bacteriological infection and occur pustule, purulence is oozed out, purulence forms a scab, present the peculiar outward appearance of eczema, namely multiple kenel erythra exists simultaneously, skin of anus is a sensitizing range, acute eczema pruritus is particularly violent, fecal pollution more easily causes bacteriological infection, Symptoms is heavier, easily extensible and perineum, scrotum, skin of buttock, affect minimal invasive treatment and work, make course of disease extremely unstable, therapeutic process extends, and transfer chronic process to.Chronic eczema: crissum chronic eczema is more common compared with acute eczema, topical manifestations is pachyderma, and lichen changes, and pleat is chapped obviously, and tendency is oozed out, acute pruritus, chronic process, is easy to recurrence.
It is empty that the traditional Chinese medical science thinks that endogenous cause of ill that anal eczema occurs is mainly body element, and natural endowment is not resistance to, feelings will internal injury, eating and drinking without temperance and cause function of liver and spleen imbalance, thus produce endogenous dampness interior-heat and prolonged illness consumption impairment of YIN blood and cause endogenous wind.Exopathogenic factor is mainly the damp and hot heresy of diseases caused by exogenous pathogenic factor.Within because main, by the traditional Chinese medical science, exopathogenic factor thinks that endogenous cause of ill that anal eczema occurs is mainly body element empty, and natural endowment is not resistance to, feelings will internal injury, eating and drinking without temperance and cause function of liver and spleen imbalance, thus produces endogenous dampness interior-heat and prolonged illness consumes impairment of YIN blood and causes endogenous wind.Exopathogenic factor is mainly the damp and hot heresy of diseases caused by exogenous pathogenic factor.Within because main, external causes become operative through internal causes, damp invasion of lower energizer, and blood-deficiency and wind-dry is the basic pathogenesis of primary disease.And the traditional Chinese medical science have that prolonged illness must be become silted up, prolonged illness must the saying of void, wind, dry, wet, hot heresy are pented up for a long time in anus, make it QI-blood circulation and lose smooth, passages through which vital energy circulates retardance and send out as congestion, congestion resistance network, and blood vessels are not flourish, failure of skin and muscle to be nourished and cause primary disease.Chronic anal eczema is thick because skin increases, thicken and affect the absorption of medicine, and affect therapeutic effect, patient locally scratches in addition, causes skin lesion and lichenification increases the weight of, and prevents again the absorption of medicine further.Clinical many employing antihistaminics are oral and contain steroid hormone medicine external curing.The common untoward reaction of antihistaminic has central inhibitory action, headache, psychomotor impairment and cholinolytic effect, gastrointestinal reaction etc.; In Pevisone paste triamcinolone acetonide be a kind of middle epistasis fluoridize glucocorticoid, there is antiinflammatory and anti-allergy action, econazole nitrate is a kind of imidazole derivative, for broad-spectrum antifungal medicine, all effective to dermatophytosis, yeast etc., because this medical instrument has antiinflammatory, antifungal, antiallergic action three kinds effect, so obtain good efficacy in treatment anal eczema, but because of the glucocorticoid that triamcinolone acetonide is wherein middle epistasis, easily rebound after drug withdrawal, and likely make potential infection focus activity and diffusion.
Summary of the invention
The present inventor is based on anal eczema pathogenesis, fully absorbing and inheriting on the medical experience basis of forefathers, in conjunction with clinical experience for many years, grope through repeatedly clinical and debug, choose one group has good therapeutic effect external medicine composition to anal eczema, thus complete the present invention.
First object of the present invention is to provide a kind of external medicine composition for the treatment of anal eczema.
Second object of the present invention is to provide a kind of method preparing above-mentioned external medicine composition.
3rd object of the present invention is to provide the purposes of above-mentioned external medicine composition in preparation treatment anal eczema medicine.
Above-mentioned purpose of the present invention is achieved by the following technical solution:
Treat an external medicine composition for anal eczema, be made up of following crude drug: Fructus Zanthoxyli, Fructus Cnidii, Radix Sophorae Flavescentis, the Radix Stemonae, Cortex Phellodendri, Folium Artemisiae Argyi, Natrii Sulfas, Galla Chinensis, Alumen, Flos Lonicerae.
Preferably, the weight portion of each crude drug is: Fructus Zanthoxyli 60-80 part, Fructus Cnidii 6-15 part, Radix Sophorae Flavescentis 10-20 part, Radix Stemonae 10-20 part, Cortex Phellodendri 10-20 part, Folium Artemisiae Argyi 6-15 part, Natrii Sulfas 6-15 part, Galla Chinensis 10-20 part, Alumen 10-20 part, Flos Lonicerae 15-30 part.
Preferred further, the weight portion of each crude drug is: Fructus Zanthoxyli 75 parts, Fructus Cnidii 10 parts, Radix Sophorae Flavescentis 15 parts, the Radix Stemonae 15 parts, Cortex Phellodendri 15 parts, Folium Artemisiae Argyi 10 parts, 10 parts, Natrii Sulfas, Galla Chinensis 15 parts, Alumen 10 parts, Flos Lonicerae 25 parts.
In the prescription of Chinese medicine hip bath agent of the present invention: Fructus Zanthoxyli is pungent, warm, enter spleen, stomach, kidney channel, warming middle-JIAO, pain relieving, parasite killing; Fructus Cnidii is pungent, bitter, dispels the wind, dampness, parasite killing, antipruritic; Radix Sophorae Flavescentis is cold in nature, bitter in the mouth, GUIXIN, liver, stomach, large intestine, urinary bladder channel, heat clearing and damp drying, parasite killing, diuresis; The Radix Stemonae is put down, and sweet in the mouth, hardship, return lung meridian, nourishing the lung to arrest cough, delousing parasite killing; Cortex Phellodendri is cold in nature, bitter in the mouth, returns kidney, urinary bladder channel, heat clearing and damp drying, and pathogenic fire purging removes steams, detoxification sore treatment; Folium Artemisiae Argyi bitter in the mouth, pungent, warm in nature, return liver,spleen,kidney warp, bitter dry pungent loose, blood of regulating the flow of vital energy, warming the meridian arteries and veins, by cold-damp, only cold type of pain; Natrii Sulfas is salty, bitter, cold, returns stomach, large intestine channel, purging heat to relax the bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat; Gallic acid, flat, enter lung, stomach, large intestine channel, astringe the lung, astringing intestine to stop diarrhea, hemostasis, removing toxic substances; Alumen is sour and astringent, cold, poisonous, expectorant, dampness, antidiarrheal, hemostasis, removing toxic substances, parasite killing; Flos Lonicerae is sweet cold, heat-clearing and toxic substances removing, antibacterial, antibacterium toxin, antipyretic and anti-inflammatory.
Full side share, and plays heat clearing and damp drying altogether, the merit of killing parasites for relieving itching.Utilize Chinese medicine fumigation and washing, can stimulate anus place blood vessel and nerve, cause podex vasodilation, thus promote local blood and lymph circulation, what is called is controlled wind and is first controlled blood, and blood wind, from going out, is suitable for long-term prescription, is conducive to the treatment of anal eczema.
Crude drug used by the present invention all can be bought from common pharmacy and obtain, and its specification meets national medical standards.
Medicine activity component of the present invention can add various adjuvants required when preparing different exterior-applied formulation, be prepared into the suitable external preparation of any one with the method for Chinese medicinal of routine, this external preparation includes but not limited to: Wet-dressing agent, water decoction, ointment, spray, liniment, powder, gel, lotion, hip bath agent, granule or gauze agent.
Further, the invention provides a kind of method preparing above-mentioned external medicine composition, comprise the following steps:
(1) each crude drug is taken by described weight portion;
(2) above-mentioned raw materials medicine is mixed, after soaking 1-2 hour, decoct 2 times, merge decoction liquor and filter, by this area common process preparation, being prepared into external preparation.
Preferably, above-mentioned raw materials medicine mixes in (2) by step, after adding water soaking 1-2 hour of 8 times of weight, decocts 2 times, decocts 30-40min at every turn.
Further, present invention also offers the purposes of above-mentioned external medicine composition in preparation treatment anal eczema medicine.
The usage of Chinese medicine composition of the present invention and consumption: the consumption of Chinese medicine composition of the present invention depends on concrete dosage form, and the factor such as the age of patient, body weight, health status.As guidance: water decoction: patients during acute stage cold wet compress, chronic phase patient fumigates demibain to thermophilic while hot, each 20-30min, every day 2 times, within 10 days, is a course for the treatment of.The suitable light diet of treatments period, avoids pungent stimulation food, takes a good rest.
Beneficial effect of the present invention is embodied in:
The present invention can safe and effective treatment anal eczema, method determined curative effect, and relapse rate is low, cheap, is easy to extensive popularization, is especially applicable to basic hospital and extensively carries out popularization.
Detailed description of the invention
Below by experiment, also the present invention will be further described in conjunction with the embodiments, it should be understood that these embodiments only for the object of illustration, never limit the scope of the invention.
The preparation of embodiment 1 water decoction
Each crude drug is taken: Fructus Zanthoxyli 75g, Fructus Cnidii 10g, Radix Sophorae Flavescentis 15g, Radix Stemonae 15g, Cortex Phellodendri 15g, Folium Artemisiae Argyi 10g, Natrii Sulfas 10g, Galla Chinensis 15g, Alumen 10g, Flos Lonicerae 25g by following weight; Above-mentioned raw materials medicine is mixed, after adding water soaking 1-2 hour of 8 times of weight, with soak by water 2 times, decocts 30-40min at every turn, merge decoction liquor, filter and get final product.
The preparation of embodiment 2 water decoction
Each crude drug is taken: Fructus Zanthoxyli 60g, Fructus Cnidii 6g, Radix Sophorae Flavescentis 10g, Radix Stemonae 10g, Cortex Phellodendri 10g, Folium Artemisiae Argyi 6g, Natrii Sulfas 6g, Galla Chinensis 10g, Alumen 10g, Flos Lonicerae 15g by following weight; Above-mentioned raw materials medicine is mixed, after adding water soaking 1-2 hour of 8 times of weight, with soak by water 2 times, decocts 30-40min at every turn, merge decoction liquor, filter and get final product.
The preparation of embodiment 3 water decoction
Each crude drug is taken: Fructus Zanthoxyli 80g, Fructus Cnidii 15g, Radix Sophorae Flavescentis 20g, Radix Stemonae 20g, Cortex Phellodendri 20g, Folium Artemisiae Argyi 15g, Natrii Sulfas 15g, Galla Chinensis 20g, Alumen 20g, Flos Lonicerae 30g by following weight; Above-mentioned raw materials medicine is mixed, after adding water soaking 1-2 hour of 8 times of weight, with soak by water 2 times, decocts 30-40min at every turn, merge decoction liquor, filter and get final product.
The preparation of embodiment 4 granule
Each crude drug is taken: Fructus Zanthoxyli 75g, Fructus Cnidii 10g, Radix Sophorae Flavescentis 15g, Radix Stemonae 15g, Cortex Phellodendri 15g, Folium Artemisiae Argyi 10g, Natrii Sulfas 10g, Galla Chinensis 15g, Alumen 10g, Flos Lonicerae 25g by following weight; Above-mentioned raw materials medicine is mixed, after adding water soaking 1-2 hour of 8 times of weight, with soak by water 2 times, decocts 30-40min at every turn, merge decoction liquor, filter, filtrate is concentrated, dry, by this area common process preparation, every bag of 10g, can obtain the granule of the 1 day consumption meeting adult normal.
The preparation of embodiment 5 granule
Each crude drug is taken: Fructus Zanthoxyli 60g, Fructus Cnidii 6g, Radix Sophorae Flavescentis 10g, Radix Stemonae 10g, Cortex Phellodendri 10g, Folium Artemisiae Argyi 6g, Natrii Sulfas 6g, Galla Chinensis 10g, Alumen 10g, Flos Lonicerae 15g by following weight; Above-mentioned raw materials medicine is mixed, after adding water soaking 1-2 hour of 8 times of weight, with soak by water 2 times, decocts 30-40min at every turn, merge decoction liquor, filter, filtrate is concentrated, dry, by this area common process preparation, every bag of 10g, can obtain the granule of the 1 day consumption meeting adult normal.
The preparation of embodiment 6 granule
Each crude drug is taken: Fructus Zanthoxyli 80g, Fructus Cnidii 15g, Radix Sophorae Flavescentis 20g, Radix Stemonae 20g, Cortex Phellodendri 20g, Folium Artemisiae Argyi 15g, Natrii Sulfas 15g, Galla Chinensis 20g, Alumen 20g, Flos Lonicerae 30g by following weight; Above-mentioned raw materials medicine is mixed, after adding water soaking 1-2 hour of 8 times of weight, with soak by water 2 times, decocts 30-40min at every turn, merge decoction liquor, filter, filtrate is concentrated, dry, by this area common process preparation, every bag of 10g, can obtain the granule of the 1 day consumption meeting adult normal.
The preparation of embodiment 7 ointment
Each crude drug is taken: Fructus Zanthoxyli 75g, Fructus Cnidii 10g, Radix Sophorae Flavescentis 15g, Radix Stemonae 15g, Cortex Phellodendri 15g, Folium Artemisiae Argyi 10g, Natrii Sulfas 10g, Galla Chinensis 15g, Alumen 10g, Flos Lonicerae 25g by following weight; Above-mentioned raw materials medicine is mixed, after adding water soaking 1-2 hour of 8 times of weight, with soak by water 2 times, decocts 30-40min at every turn, merge decoction liquor, filter, filtrate is concentrated, being blended into Natrii Sulfas, take vaseline as substrate, is prepared into ointment by this area common process.
The preparation of embodiment 8 ointment
Each crude drug is taken: Fructus Zanthoxyli 60g, Fructus Cnidii 6g, Radix Sophorae Flavescentis 10g, Radix Stemonae 10g, Cortex Phellodendri 10g, Folium Artemisiae Argyi 6g, Natrii Sulfas 6g, Galla Chinensis 10g, Alumen 10g, Flos Lonicerae 15g by following weight; Above-mentioned raw materials medicine is mixed, after adding water soaking 1-2 hour of 8 times of weight, with soak by water 2 times, decocts 30-40min at every turn, merge decoction liquor, filter, filtrate is concentrated, being blended into Natrii Sulfas, take vaseline as substrate, is prepared into ointment by this area common process.
The preparation of embodiment 9 ointment
Each crude drug is taken: Fructus Zanthoxyli 80g, Fructus Cnidii 15g, Radix Sophorae Flavescentis 20g, Radix Stemonae 20g, Cortex Phellodendri 20g, Folium Artemisiae Argyi 15g, Natrii Sulfas 15g, Galla Chinensis 20g, Alumen 20g, Flos Lonicerae 30g by following weight; Above-mentioned raw materials medicine is mixed, after adding water soaking 1-2 hour of 8 times of weight, with soak by water 2 times, decocts 30-40min at every turn, merge decoction liquor, filter, filtrate is concentrated, being blended into Natrii Sulfas, take vaseline as substrate, is prepared into ointment by this area common process.
The report of test example 1 external medicine composition treatment of the present invention anal eczema clinical summary
1, clinical data
Inventor collects the out-patient of 300 routine anal eczemas altogether, age 10-79 year.Adopt random method, be divided into treatment group: 200 examples, matched group: 100 examples.Two groups of data such as age, the state of an illness, without significant difference, have comparability.
2, test method
2.1 treatment groups: use the water decoction that embodiment 1 is obtained, patients during acute stage cold wet compress, chronic phase patient fumigates demibain to thermophilic while hot, each 20-30min, early, evening is each once, 10 days courses for the treatment of, the suitable light diet of treatments period, avoids pungent stimulation food, takes a good rest.
2.2 matched groups: use clarityne, 10mg, every day 1 time, oral; Pevisone paste, external, every day 2 times.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Observation index: 1. symptom: scratchiness, skin lesion situation; 2. follow up a case by regular visits to: all patients is followed up a case by regular visits to; 3. untoward reaction.
Curative effect determinate standard: recovery from illness: clinical symptoms all disappears, skin lesion heals; Take a turn for the better: clinical symptom relief, skin lesion heals substantially, lab testing improvement or normal; Invalid: clinical symptoms is without being clearly better or increasing the weight of, and skin lesion is without healing.
3.2 statistical method
By the data obtained software processes, enumeration data application X2 checks.
3.3 statistics therapeutic outcomes are in table 1.
Table 1 a liang group patient outcomes compare
Group | Case load (n) | Recovery from illness | Take a turn for the better | Invalid | Untoward reaction | Total effective rate (%) |
Treatment group | 200 | 139 | 47 | 14 | 0 | 97% |
Matched group | 100 | 31 | 48 | 21 | 30 | 79% |
Two groups of patient outcomes's comparative descriptions, treatment group effective percentage is significantly higher than matched group (P < 0.01), illustrates that external medicine composition of the present invention effectively can treat anal eczema, and has no adverse reaction compared with Western medicine.
The foregoing is only the preferred embodiments of the present invention, is only illustrative for the purpose of the present invention, and nonrestrictive; Those of ordinary skill in the art understand, and can carry out many changes in the spirit and scope that the claims in the present invention limit to it, amendment, and even equivalence is changed, but all will fall within the scope of protection of the present invention.
Claims (8)
1. treat an external medicine composition for anal eczema, be made up of following crude drug: Fructus Zanthoxyli, Fructus Cnidii, Radix Sophorae Flavescentis, the Radix Stemonae, Cortex Phellodendri, Folium Artemisiae Argyi, Natrii Sulfas, Galla Chinensis, Alumen, Flos Lonicerae.
2. external medicine composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Fructus Zanthoxyli 60-80 part, Fructus Cnidii 6-15 part, Radix Sophorae Flavescentis 10-20 part, Radix Stemonae 10-20 part, Cortex Phellodendri 10-20 part, Folium Artemisiae Argyi 6-15 part, Natrii Sulfas 6-15 part, Galla Chinensis 10-20 part, Alumen 10-20 part, Flos Lonicerae 15-30 part.
3. external medicine composition according to claim 2, it is characterized in that, the weight portion of each crude drug is: Fructus Zanthoxyli 75 parts, Fructus Cnidii 10 parts, Radix Sophorae Flavescentis 15 parts, the Radix Stemonae 15 parts, Cortex Phellodendri 15 parts, Folium Artemisiae Argyi 10 parts, 10 parts, Natrii Sulfas, Galla Chinensis 15 parts, Alumen 10 parts, Flos Lonicerae 25 parts.
4. the external medicine composition according to claim 1-3, is characterized in that, is prepared into external preparation suitable clinically according to Chinese medicine conventional formulation method.
5. external medicine composition according to claim 4, is characterized in that, described preparation comprises Wet-dressing agent, water decoction, ointment, spray, liniment, powder, gel, lotion, hip bath agent, granule or gauze agent.
6. prepare a method for the external medicine composition described in any one of claim 1-3, it is characterized in that, comprise the following steps:
(1) each crude drug is taken by described weight portion;
(2) above-mentioned raw materials medicine is mixed, after soaking 1-2 hour, decoct 2 times, merge decoction liquor and filter, by this area common process preparation, being prepared into external preparation.
7. method according to claim 6, is characterized in that, above-mentioned raw materials medicine mixes in (2) by step, after adding water soaking 1-2 hour of 8 times of weight, decocts 2 times, decocts 30-40min at every turn.
8. the purposes of the external medicine composition described in any one of claim 1-3 in preparation treatment anal eczema medicine.
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