CN104491447A - 一种治疗胃肠道肿瘤的复方药物 - Google Patents

一种治疗胃肠道肿瘤的复方药物 Download PDF

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CN104491447A
CN104491447A CN201410850376.1A CN201410850376A CN104491447A CN 104491447 A CN104491447 A CN 104491447A CN 201410850376 A CN201410850376 A CN 201410850376A CN 104491447 A CN104491447 A CN 104491447A
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潘振奎
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Abstract

本发明公开了一种治疗胃肠道肿瘤的复方药物，由以下重量份数的中药原料配制而成：猫爪草3-5份、水红花子4-6份、没药3-5份、冬凌草3-5份、青黛3-5份、山豆根5-8份、桔梗2-4份、丹皮2-4份、黄芪6-10份、太子参6-8份、灵芝1-3份、阿胶5-8份、合欢皮8-10份、夏枯草2-5份、黄岑2-4份、黄柏2-4份、连翘2-4份、蒲公英2-4份、山慈菇2-5份、败酱草3-5份、薤白2-3份、大蓟5-8份、海藻3-5份和昆布3-5份，根据中药扶正固本、活血化瘀的理论，补益肝肾、益气养阴、清热解毒，解散消肿，治疗胃肠道肿瘤，标本兼治，疗效好，见效快。

Description

一种治疗胃肠道肿瘤的复方药物
技术领域
本发明属于中医中药技术领域，特别涉及一种治疗胃肠道肿瘤的复方药物。
背景技术
胃肠道肿瘤是发生于胃部、小肠和大肠的良性、恶性肿瘤。临床表现因肿瘤发生的性质和部位而异。一般来说，良性肿瘤可无症状或症状很轻。有的恶性肿瘤早期也无明显症状，从而影响诊断、治疗和预后。胃肠道肿瘤中，小肠肿瘤的发病率较食管、胃和大肠等部位为低。
表现为轻重不等的腹痛、肠道出血、肠梗阻、腹部肿块及体重减轻等。恶性肿瘤的症状较多、较重，良性肿瘤的症状较轻或根本无症状。由于胃肠肿瘤缺乏特异性症状和体征，因此，很难早期诊断。
在中国，胃肠道肿瘤发病率和死亡率均高居第二位，极大地威胁着人类的生命和健康。2012年，全国肿瘤人口标化发病率为146.87/10万人，其中消化***的胃癌占12.67％，肠癌占10.30％，肝癌占10.04％，食管癌占7.74％，其防治形势十分严峻态。在我国，对于每个患者，抗肿瘤药物的费用都是一项沉重的负担。除了常规的化疗药物外，人源化抗体药物、分子靶向药物、新型靶向载体药物均十分昂贵。而中医中药历史悠久，疗效确切，同时价格低廉，适于推广。故如何挖掘中医药在抗肿瘤方面的宝藏，更好地造福患者，是每个中医药工作者面临的现实问题。
消化道肿瘤瘤体在短时间内迅速增大，耗损人体的气血津液，使得机体和脏腑功能日渐虚衰，表现为邪盛正衰的病理特征，此时治法当补虚扶正为主；除了原发灶之外，患者常常在手术后还会出现远处转移，故结合收敛解毒，效果独特。
发明内容
本发明提供一种治疗胃肠道肿瘤的复方药物，根据中医肿瘤学理论，通过中药调理，扶正固本、活血化瘀，从清热解毒，除疾散结、活血通经、解散消肿，益气养阴等方面进行调整治疗，治疗胃肠道肿瘤，以期获得最好的治疗效果。
本发明的治疗胃肠道肿瘤的复方药物，其特征在于由以下重量份数的中药原料配制而成：猫爪草3-5份、水红花子4-6份、没药3-5份、冬凌草3-5份、青黛3-5份、山豆根5-8份、桔梗2-4份、丹皮2-4份、黄芪6-10份、太子参6-8份、灵芝1-3份、阿胶5-8份、合欢皮8-10份、夏枯草2-5份、黄岑2-4份、黄柏2-4份、连翘2-4份、蒲公英2-4份、山慈菇2-5份、败酱草3-5份、薤白2-3份、大蓟5-8份、海藻3-5份和昆布3-5份。
作为优选，按如下重量份数配制：猫爪草4份、水红花子5份、没药3份、冬凌草4份、青黛4份、山豆根6份、桔梗3份、丹皮3份、黄芪8份、太子参7份、灵芝2份、阿胶6份、合欢皮10份、夏枯草4份、黄岑3份、黄柏3份、连翘3份、蒲公英3份、山慈菇4份、败酱草4份、薤白2份、大蓟7份、海藻5份和昆布5份。
制备方法是按上述重量份数称取原料，放入砂锅里，然后加入饮用水，液面超出药材2-3cm，武火煮开后，改用文火煎煮50分钟后，倒出药液，每次温服200-300ml，每日早、晚两次饭前服用。
药理分析：
猫爪草：甘、辛，微温。归肝、肺经。主治瘰疬痰核，疔疮，虫蛇咬伤。
水红花子：有化痞散结，清热止痛功能。用于痞块腹胀，消渴，胃痛。
没药：主治胸腹瘀痛、痛经、经闭、症瘕、跌打损伤、痈肿疮疡、肠痈、目赤肿痛。有活血止痛、消肿生肌等功效。
冬凌草：又名冰凌草，为唇形科香茶属多年生草本或亚灌木，小灌木。性味苦、甘、微寒，有良好清热毒、活血止痛、抑菌、抗肿瘤作用。
青黛：为双子叶植物药爵床科植物马蓝、双子叶植物药豆科植物木蓝、双子叶植物药十字花科植物菘蓝、草大青或蓼科植物蓼蓝叶中的干燥色素。性味咸寒，清热解毒，凉血、消斑，清肝泻火，定惊。主治：温病热盛，斑疹，吐血、咯血，咽痛口疮、小儿惊痫、疮肿、丹毒、蛇虫咬伤。龙葵：全株入药，可散瘀消肿，清热解毒。本方中，取其活血排脓，抗癌肿作用。
山豆根：别名：三小叶山豆根、胡豆莲，具有消肿抗癌作用。
桔梗：别名包袱花、铃铛花、僧帽花，功能主治：宣肺，利咽，祛痰，排脓。利咽化痰，导药升阳作用。
丹皮：苦辛，微寒。归心、肝、肾经。清热凉血，活血散瘀。《本草纲目》：“治血中伏火，除烦热”。
黄芪：有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。
夏枯草：辛、苦、寒；肝、胆经；清热泻火、明目、散结消肿。
黄岑：苦、寒。肺、胆、脾、胃、大肠、清热燥湿、泻火解毒、止血。用于痈肿疮毒。
黄柏：苦、寒。肾、膀胱、大肠经；清热燥湿、泻火解毒；用于痈肿疮毒。
连翘：苦、微寒、肺、心、小肠经；清热解毒、散肿消结、用于痈肿疮毒、瘰疬痰核。
蒲公英：苦、甘、寒；肝、胃经；清热解毒、消肿散结。
山慈菇：甘、微辛、凉；肝、脾经；清热解毒、消痈散疖；用于痈肿疔毒、瘰疬痰核、癓瘕痞块。
败酱草：辛、苦；微寒；肝、胃、大肠经；清热解毒、消肿排脓、祛瘀止痛，用于肠痈肺痈、痈肿疮毒。
薤白：辛、苦、温；肺、胃、大肠经；通阳散结、行气导滞。
大蓟：甘、苦、凉；心、肺经；凉血止血、散瘀解毒、消痈。
海藻：咸、寒；肝、肾经；消痰软坚、利水消肿；用于瘿瘤、瘰疬痰核、肿瘤。
昆布：咸、寒；肝、肾经；消痰软坚、利水消肿；用于瘿瘤、瘰疬痰核、肿瘤。
合欢皮：甘、平；心、肺、肝经；解郁安神、活血消肿；用于心神不宁、失眠多梦、肺痈、疮痈肿毒。
灵芝：甘、平；心、肺、肾、肝经；安神补虚。
太子参：甘、微苦、平；脾、肺经；补气健脾、生津润肺。
阿胶：甘、平；肺、肝、肾经；补血、滋阴、润肺、止血。
本发明的复方药物，海藻、昆布软坚散结、消肿；黄芪、太子参、阿胶、灵芝、合欢皮补益肝肾、滋阴生津；选用败酱草、山慈菇、蒲公英、连翘、黄柏、黄岑等消肿拔毒、清热解毒；薤白具有通阳散结、行气导滞的功效；水红花子、没药、败酱草同时具有止痛的功效；诸药配伍，补益肝肾、益气养阴、清热解毒，解散消肿，治疗胃肠道肿瘤，标本兼治，疗效好，见效快。
疗效判断：
胃肠道肿瘤的主要临床症状有：表现轻重不等的腹痛、肠道出血、肠梗阻、腹部肿块及体重减轻等；恶性肿瘤的症状较多、较重，良性肿瘤的症状较轻或根本无症状；CT显示有瘤体。
显效：瘤体消失、体征及症状改善，饮食及大便正常。
好转：瘤体缩小，体征及症状有改善。
无效：体征及瘤体大小如前或瘤体增大。
治疗结果：胃肠道肿瘤患者148例，服用本发明的药物，放入砂锅里，然后加入饮用水，液面超出药材2-3cm，武火煮开后，改用文火煎煮50分钟后，倒出药液，每次温服200-300ml，每日早、晚两次饭前温服。显效93例，占60％，好转28例，占19％，有效率为79％。
附几例病例作进一步说明：
病例1：王某某，女，51岁，山东青岛人，2013年9月来诊，自觉大便不顺、坠胀难出，直肠镜检查发现一个2.0×1.0×1.3cm大小肿块，诊断为直肠瘤。服用本发明的药物，14天后直肠镜检查，肿块减小至之前的1/2，坠胀感减轻，继续服用14天后，复检，肿块基本消失，症状均消失，继续服用14天巩固疗效，随访3个月，康复正常。
病例2：姜某，男，39岁，2013年7月来诊，自觉身体不适，大便次数增多带血，通过直肠内超声扫描，发现肿块，作病理检查，确诊为直肠瘤，瘤体大小2.3×1.5×1.7cm，服用本发明的药物，28天后瘤体缩小至1.5×0.9×1.0cm，大便次数减少，症状缓解，继续服用21天后瘤体继续减小至0.3×0.3×0.2cm，14天后，复检痊愈，随访半年无复发。
具体实施方式
实施例1
猫爪草4份、水红花子5份、没药3份、冬凌草4份、青黛4份、山豆根6份、桔梗3份、丹皮3份、黄芪8份、太子参7份、灵芝2份、阿胶6份、合欢皮10份、夏枯草4份、黄岑3份、黄柏3份、连翘3份、蒲公英3份、山慈菇4份、败酱草4份、薤白2份、大蓟7份、海藻5份和昆布5份。
制备方法是按上述重量份数称取原料，放入砂锅里，然后加入饮用水，液面超出药材2.5cm，武火煮开后，改用文火煎煮50分钟后，倒出药液，每次温服250ml，每日早、晚两次饭前温服，14天为一个疗程。

Claims (2)

1.一种治疗胃肠道肿瘤的复方药物，其特征在于由以下重量份数的中药原料配制而成：猫爪草3-5份、水红花子4-6份、没药3-5份、冬凌草3-5份、青黛3-5份、山豆根5-8份、桔梗2-4份、丹皮2-4份、黄芪6-10份、太子参6-8份、灵芝1-3份、阿胶5-8份、合欢皮8-10份、夏枯草2-5份、黄岑2-4份、黄柏2-4份、连翘2-4份、蒲公英2-4份、山慈菇2-5份、败酱草3-5份、薤白2-3份、大蓟5-8份、海藻3-5份和昆布3-5份。
2.根据权利要求1所述的治疗胃肠道肿瘤的复方药物，其特征在于由以下重量份数的中药原料配制而成：猫爪草4份、水红花子5份、没药3份、冬凌草4份、青黛4份、山豆根6份、桔梗3份、丹皮3份、黄芪8份、太子参7份、灵芝2份、阿胶6份、合欢皮10份、夏枯草4份、黄岑3份、黄柏3份、连翘3份、蒲公英3份、山慈菇4份、败酱草4份、薤白2份、大蓟7份、海藻5份和昆布5份。
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CN105535677A (zh) * 2015-12-28 2016-05-04 许琳 一种治疗胃肠道肿瘤的复方药物
CN105535821A (zh) * 2015-12-28 2016-05-04 黄维清 一种治疗胃肠道肿瘤的复方药物
CN105535597A (zh) * 2015-12-28 2016-05-04 许琳 一种治疗胃肠道肿瘤的复方药物

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CN105535677A (zh) * 2015-12-28 2016-05-04 许琳 一种治疗胃肠道肿瘤的复方药物
CN105535821A (zh) * 2015-12-28 2016-05-04 黄维清 一种治疗胃肠道肿瘤的复方药物
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