CN104474497A - 治疗消化性溃疡的中药 - Google Patents

治疗消化性溃疡的中药 Download PDF

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CN104474497A
CN104474497A CN201410682894.7A CN201410682894A CN104474497A CN 104474497 A CN104474497 A CN 104474497A CN 201410682894 A CN201410682894 A CN 201410682894A CN 104474497 A CN104474497 A CN 104474497A
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rhizoma
peptic ulcer
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毕占岁
原晓红
胡艳玲
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Abstract

本发明涉及一种药物配方领域，具体地说是一种治疗消化性溃疡的中药，其特征在于由如下重量份的原料药制成：鸡骨草8-11，鸡内金3-5，黄芪10-12，黄连2-4，香附3-5，降香4-6，竹茹2-5，柿蒂4-7，瓦楞子4-6，甘松2-4，合欢皮4-6，肉豆蔻2-5，焦稻芽6-9，荜茇1-3，海螵蛸3-5，莪术3-5，吴茱萸1-3，生姜3-5，芦根8-10，三棱3-5，将上述原料药加水煎熬，去渣得滤液。本发明疗效显著、成本低廉、无任何毒副作用。

Description

治疗消化性溃疡的中药
技术领域
本发明涉及一种中成药制剂，具体地说是一种治疗消化性溃疡的中药。
背景技术
众所周知，消化性溃疡是一种全球性常见病，主要指发生在胃和十二指肠的慢性溃疡，属中医“胃脘痛、吐酸”等病症范畴，主要症状为上腹疼痛、胀满、反酸、嗳气、情志不畅、食欲不振、乏力、反复发作，发作期可为数周或数月。胃镜检查可确诊，并且大部分患者幽门螺旋杆菌阳性。幽门螺旋杆菌和非甾体抗炎药是损害胃十二指肠粘膜屏障，从而导致消化性溃疡发病的最常见病因。随着现代社会人们生活节奏加快和饮食结构变化，消化性溃疡的发病率也越来越高，不仅严重影响着人类的生命健康，其中一切病理改变又与胃癌发生有密切关系，西医治疗存在溃疡愈合欠佳与复发等问题，有研究表明有效率仅为42左右。
发明内容
本发明的目的就是为了克服上述现有的技术不足，提供一种治疗消化性溃疡的中药，成本低、治疗消化性溃疡疗效高、无毒副作用、具有疏肝理气、敛口生肌、活血化瘀、制酸止痛、降逆止呕、温中止泻、和胃健脾之功效，既适于消化性溃疡，对慢性胃炎也有效。
本发明解决上述技术问题采用的技术方案是：一种治疗消化性溃疡的中药，其特征在于由如下重量份的原料药制成：鸡骨草8-11，鸡内金3-5，黄芪10-12，黄连2-4，香附3-5，降香4-6，竹茹2-5，柿蒂4-7，瓦楞子4-6，甘松2-4，合欢皮4-6，肉豆蔻2-5，焦稻芽6-9，荜茇1-3，海螵蛸3-5，莪术3-5，吴茱萸1-3，生姜3-5，芦根8-10，三棱3-5，将上述原料药加水煎熬，去渣得滤液。
本发明的有益效果是，成本低、治疗消化性溃疡疗效高、无毒副作用、具有疏肝理气、敛口生肌、活血化瘀、制酸止痛、降逆止呕、温中止泻、和胃健脾之功效，既适于消化性溃疡，对慢性胃炎也有效。
具体实施方式
下面结合实施例对本发明作进一步的描述：
实施例1：
采用鸡骨草、鸡内金、黄芪、黄连、香附、降香、竹茹、柿蒂、瓦楞子、甘松、合欢皮、肉豆蔻、焦稻芽、荜茇、海螵蛸、莪术、吴茱萸、生姜、芦根、三棱为原料制备而成。其组分(重量份)每付为鸡骨草10.5、鸡内金4.6、黄芪11.4、黄连3.3、香附4.4、降香5.2、竹茹3.3、柿蒂5.1、瓦楞子4.7、甘松2.9、合欢皮5.5、肉豆蔻3.8、焦稻芽6.7、荜茇1.6、海螵蛸4.6、莪术4.1、吴茱萸1.5、生姜4.3、芦根8.2、三棱4.3。取上述20味原料总重量为216克。瓦楞子加水150ml单泡，降香单包，鸡内金捣碎，与余下中草药加水1100ml左右，在室温下浸泡3-4小时，瓦楞子先煮沸，文火煎10分钟左右，再倒入浸泡18味中草药武火煮沸，文火煎熬至30分钟，再加入单包降香煮沸煎熬20分钟，去渣得滤液200ml，药渣再加水300ml，煎熬30-40分钟，去渣得滤液100ml，共得300ml左右药汁，即制得本发明汤剂，装入无菌玻璃瓶内，密封瓶盖备用，每日1剂分2次口服，饭后2小时口服。10天为一疗程，服1疗程停2天，再服下一疗程，一般应用四个疗程。
本发明主药鸡骨草为豆科植物广州相思子的干燥全珠，化学成分：根叶含草甜素，种子含相思子碱，胆碱。此外，可能含一种甾醇类化合物。性味甘、微苦、凉，归肝、胃经。具有清热解毒，舒肝止痛功效，用于黄疸、胁肋不舒、胃脘胀痛，慢性肝炎、乳腺炎。鸡内金化学成分主药由蛋白质构成，并含有胃激素等。临床药理观察，口服鸡内金后，胃液的分泌量酸度及消化力三者均见增高，其中消化力的增高出现较迟缓，维持也持久，服药后胃运动功能明显增强，表现在胃运动期延长及蠕动波增强。由于胃运动增强，故胃排空率也加快。鸡内金本身并不含有任何消化酶，由于上述分泌及运动方面的变化并非服药后立即产生，而必须经过一段时间。故其作用是由药物被吸收到血液后的某种体液因素引起的。临床观察证明，鸡内金对于各种消化不良病症是有较满意的疗效的。性味甘、平、归脾、小肠、膀胱经。具有健胃消食，涩精止遗功效，用于食积不消，呕吐泻痢、小儿疳积、遗尿、遗精。黄芪性味甘、温、归肺、脾经。具有补气因素，利尿托毒、排脓、敛疮生肌功效，用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴、慢性肾炎蛋白尿，糖尿病。黄连性味苦、寒、归心、脾、胃、肝、胆、大肠经。具有清热燥湿、泻水解毒功效，用于湿热痞满、呕吐吞酸、泻痢、黄疸、高热神昏、心火亢盛、心烦不寐、血热吐衄，目赤，牙痛，消渴，痈肿疔疮等。香附性味辛、微苦、微甘、平，归肝、脾、三焦经，具有行气解郁，调经止痛功能，用于肝郁气滞，胸、胁、脘腹胀痛，消化不良，胸脘痞闷，寒疝腹痛，***胀痛，***，经闭痛经。降香性味辛、温、归肝、脾经，具有行气活血，止痛，止血功能，用于脘腹疼痛，肝郁胁痛，胸痹刺痛，跌打损伤，外伤出血。竹茹性味甘，微寒，归肺，胃经。具有清热化痰，除烦止呕功能，用于痰热咳嗽，胆长挟痰，烦热呕吐，惊悸失眠，中风痰迷，舌强不语，胃热呕吐，妊娠恶阻，胎动不安。柿蒂性味苦，涩，平，归胃经。具有降逆下气功效，用于呃逆。瓦楞子性味咸平，归肺、胃、肝经。具有消痰化瘀，软坚散结，制酸止痛功效，用于顽痰积结，粘稠难咯，瘿瘤，瘰疬，胃痛反酸。甘松性味辛、甘、温，归脾、胃经。具有理气止痛，开郁醒脾功效，用于脘腹胀满，食欲不振，呕吐。合欢皮性味甘、平，归心、肝、肺经，具有解郁安神，活血消肿功效，用于心神不安，忧郁失眠，肺痈疮肿，跌打伤痛。肉豆蔻性味辛、温、归脾、胃、大肠经。具有温中行气，涩肠止泻功效，用于脾胃虚寒，久泻不止，脘腹胀痛，食少呕吐。焦稻芽性味甘、温，归脾、胃经。具有和中消食，健脾开胃功效，用于食积不消，腹胀口臭，脾胃虚弱，不饥食少。焦稻芽善化积滞，用于积滞不消。荜茇性味辛、热，归胃、大肠经。具有温中散寒，下气止痛功效，用于脘腹冷痛，呕吐，泄泻，偏头痛。海螵蛸性味咸、涩、温，归脾、胃经。具有收敛止血，涩精止带，制酸、收敛功效，用于胃痛吞酸，吐血、衄血，崩漏便血，遗精滑精，赤白带下，胃溃疡。莪术性味辛、苦、温，归肝、脾经。具有行气破血，清积止痛功效，用于癓瘕痞块，淤血经闭、食积胀痛、早期***。吴茱萸性味辛、苦、热、有小毒，归肝、脾、胃、肾经。具有散寒止痛，降逆止呕，助阳止泻功效，用于厥阴头痛，寒疝腹痛，寒湿脚气、经行腹痛、脘腹胀痛、呕吐吞酸，五更泄泻等。生姜辛味辛、微温、归肺、脾、胃经。具有解表散寒、温中止呕，化痰止咳功效，用于风寒感冒、胃寒呕吐、寒痰咳嗽。芦根性味甘、寒、归肺、胃经，具有清热清津，除烦、止呕、利尿功效，用于热病烦渴、胃热、呕哕，肺热咳嗽，肺痈吐脓，热淋涩痛。三棱性味辛、苦、平、归肝、脾经，具有破血行气，消积止痛功效，用于癓瘕痞块，淤血经闭，食积胀痛。20味中草药巧妙组方，合理配伍，药证合拍，诸药共奏消化性溃疡之特效。
本发明各原料还可按下表所列比例(重量份)混合的实施例来实现。其加工工艺与实施例1相同。
下面结合我院，即山东省威海市文登中心医院进行的临床试验对本发明作进一步详细地描述：
1.病例选择：所选病历为2013年4月至2014年9月来我院就诊，诊断为消化性溃疡67例，男38例，女29例，年龄34.3±5.6，病程8个月至3年，其中十二指肠溃疡39例，胃溃疡28例。
2.诊断标准：参照国家中医药管理局发布的《中医病证诊断疗效标准》及陆再英、钟南山主编的《内科学》第7版：(1)胃脘部疼痛、胀满或伴嗳气、返酸、恶心、呕吐等症状。(2)发病常与情志不畅、饮食不节、劳累、受寒等因素有关。(3)纤维胃镜证实为活动性消化性溃疡，除外活动性溃疡出血，幽门梗阻、恶变等。(4)经西医内科一般治疗无效且反复发作者。
3.治疗方法：每日1剂分2次口服，饭后2小时口服。配合应用海蜇500克、大枣500克、红糖250克，先将海蜇洗净加去核大枣加水300毫升煮沸后，文火煎20分钟，再加入红糖，共煎成膏状，每日3次，每次饭前服10ml以辅助治疗。口服本发明汤剂治疗10天为一疗程，服一疗程停2天再服下一疗程，应用四个疗程。
4.疗效评价：治愈：临床症状体征全部消失或基本消失，胃镜检查溃疡及周围炎症完全消失，局部轻度发红，无明显水肿；显效：临床症状体征明显改善，胃镜检查溃疡基本消失，但仍有明显炎症；有效：主要症状和体征均有好转，胃镜检查示溃疡面缩小50以上；无效：自觉症状改善不明显或加重，胃镜检查示溃疡面缩小不足5。
5.治疗效果：使用本发明治疗67例，治疗四个疗程后，按照疗程评价标准进行治疗效果评价，治愈29例，显效24例、有效8例，无效8例，总有效率为91％。

Claims (1)

1.一种治疗消化性溃疡的中药，其特征在于由如下重量份的原料药制成：鸡骨草8-11，鸡内金3-5，黄芪10-12，黄连2-4，香附3-5，降香4-6，竹茹2-5，柿蒂4-7，瓦楞子4-6，甘松2-4，合欢皮4-6，肉豆蔻2-5，焦稻芽6-9，荜茇1-3，海螵蛸3-5，莪术3-5，吴茱萸1-3，生姜3-5，芦根8-10，三棱3-5，将上述原料药加水煎熬，去渣得滤液。
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